Base de dados : MEDLINE
Pesquisa : A12.200.250 [Categoria DeCS]
Referências encontradas : 27 [refinar]
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  1 / 27 MEDLINE  
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[PMID]:28570224
[Au] Autor:Basagaña M; Luengo O; Labrador M; Garriga T; Mattsson L; Lidholm J; Cardona V
[Ad] Endereço:Allergy Unit, Hospital Universitari Germans Trias i Pujol, Universitat Autónoma de Barcelona, Badalona, Spain.
[Ti] Título:Component-Resolved Diagnosis of Dog Allergy.
[So] Source:J Investig Allergol Clin Immunol;27(3):185-187, 2017 Jun.
[Is] ISSN:1018-9068
[Cp] País de publicação:Spain
[La] Idioma:eng
[Mh] Termos MeSH primário: Alérgenos/imunologia
Alérgenos Animais/imunologia
Cães/imunologia
Hipersensibilidade/imunologia
Imunoglobulina E/imunologia
Antígeno Prostático Específico/imunologia
Albumina Sérica/imunologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Animais
Criança
Feminino
Seres Humanos
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 0 (Can f 3 allergen, Canis familiaris); 0 (Serum Albumin); 0 (allergen Can f 2); 0 (allergen Can f I); 37341-29-0 (Immunoglobulin E); EC 3.4.21.77 (Can f 5 allergen, Canis familiaris); EC 3.4.21.77 (Prostate-Specific Antigen)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE
[do] DOI:10.18176/jiaci.0150


  2 / 27 MEDLINE  
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[PMID]:28235411
[Au] Autor:Morales M; Gallego M; Iraola V; Taulés M; de Oliveira E; Moya R; Carnés J
[Ad] Endereço:Research & Development, Laboratorios LETI, S.L., Calle del Sol n° 5, 28760, Madrid, Tres Cantos, Spain.
[Ti] Título:In vitro evidence of efficacy and safety of a polymerized cat dander extract for allergen immunotherapy.
[So] Source:BMC Immunol;18(1):10, 2017 Feb 24.
[Is] ISSN:1471-2172
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Allergy to cat epithelia is highly prevalent, being the major recommendation for allergy sufferers its avoidance. However, this is not always feasible. Allergen specific immunotherapy is therefore recommended for these patients. The use of polymerized allergen extracts, allergoids, would allow to achieve the high allergen doses suggested to be effective while maintaining safety. RESULTS: Cat native extract and its depigmented allergoid were manufactured and biochemically and immunochemically characterized. Protein and chromatographic profiles showed significant modification of the depigmented allergoid with respect to its corresponding native extract. However, the presence of different allergens (Fel d 1, Fel d 2, Fel d 3, Fel d 4 and Fel d 7) was confirmed in the allergoid. Differences in IgE-binding capacity were observed as loss of biological potency and lower stability of the IgE-allergen complex on surface plasmon resonance. The allergoid induced production of IgG antibodies able to block IgE-binding to native extract. Finally, studies carried out with peripheral-blood mononuclear cells from cat allergic patients showed that the allergoid induced IFN-γ and IL-10 production similar to that induced by native extract. CONCLUSIONS: Cat depigmented allergoid induced production of cytokines involved in a Th1 and Treg response, was able to induce production of IgG-antibodies that blocks IgE-binding to cat native extract, and showed reduced interaction with IgE, suggesting greater safety than native extract while maintaining in vitro efficacy.
[Mh] Termos MeSH primário: Extratos Celulares/imunologia
Alérgenos Animais/imunologia
Dessensibilização Imunológica/métodos
Glicoproteínas/imunologia
Hipersensibilidade/terapia
Linfócitos T Reguladores/imunologia
Células Th1/imunologia
[Mh] Termos MeSH secundário: Animais
Gatos
Células Cultivadas
Seres Humanos
Hipersensibilidade/imunologia
Imunoglobulina E/metabolismo
Interferon gama/metabolismo
Interleucina-10/metabolismo
Ativação Linfocitária
Polimerização
Ligação Proteica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cell Extracts); 0 (Glycoproteins); 130068-27-8 (Interleukin-10); 37341-29-0 (Immunoglobulin E); 82115-62-6 (Interferon-gamma); G408EE88II (Fel d 1 protein, Felis domesticus)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170226
[St] Status:MEDLINE
[do] DOI:10.1186/s12865-017-0193-0


  3 / 27 MEDLINE  
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[PMID]:27430609
[Au] Autor:Perzanowski MS; Ronmark E; James HR; Hedman L; Schuyler AJ; Bjerg A; Lundback B; Platts-Mills TA
[Ad] Endereço:Mailman School of Public Health, Columbia University, New York, NY.
[Ti] Título:Relevance of specific IgE antibody titer to the prevalence, severity, and persistence of asthma among 19-year-olds in northern Sweden.
[So] Source:J Allergy Clin Immunol;138(6):1582-1590, 2016 Dec.
[Is] ISSN:1097-6825
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Although sensitization to indoor allergens is strongly associated with asthma, there are questions as to how this relates to asthma symptoms. OBJECTIVE: We sought to study the relevance of IgE antibodies to cat and dog allergens in an area in which (1) the climate discourages cockroach, fungal, and mite growth and (2) dander allergens are known to be present in schools and houses without animals. METHODS: IgE to 8 allergens was tested in 963 sera from a population-based study on 19-year-olds, and associations with asthma symptoms, diagnosis, and treatment were examined. In positive sera IgE to specific cat and dog allergens was also assayed. RESULTS: IgE specific for animal dander had the highest prevalence and strongest relationship to asthma diagnosis. Furthermore, asthma severity, as judged by the frequency of symptoms and use of treatment, was directly associated with the titer of IgE antibodies to animal dander. Among the 103 subjects who had current asthma at age 19 years, 50 had asthma before age 12 years. Among those 50, the odds ratios for asthma related to any IgE antibodies to animal dander or high-titer IgE antibodies (≥17.5 IU/mL) were 9.2 (95% CI, 4.9-17) and 13 (95% CI, 6.9-25), respectively. In multivariable analysis IgE antibodies to Fel d 1 and Can f 5 were each associated with current asthma. CONCLUSION: High-titer IgE antibodies to cat and dog allergens were strongly associated with the diagnosis, severity, and persistence of asthma; however, a large proportion of patients with current asthma did not live in a house with a cat or dog.
[Mh] Termos MeSH primário: Alérgenos/imunologia
Asma/epidemiologia
Alérgenos Animais/imunologia
Imunoglobulina E/sangue
Animais de Estimação/imunologia
[Mh] Termos MeSH secundário: Adulto
Poluição do Ar em Ambientes Fechados/efeitos adversos
Alérgenos/efeitos adversos
Animais
Gatos
Progressão da Doença
Cães
Feminino
Seres Humanos
Masculino
Prevalência
Índice de Gravidade de Doença
Suécia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160720
[St] Status:MEDLINE


  4 / 27 MEDLINE  
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[PMID]:27152482
[Au] Autor:Lu S; Hartert TV; Everard ML; Giezek H; Nelsen L; Mehta A; Patel H; Knorr B; Reiss TF
[Ad] Endereço:Merck & Co., Inc., Kenilworth, New Jersey.
[Ti] Título:Predictors of asthma following severe respiratory syncytial virus (RSV) bronchiolitis in early childhood.
[So] Source:Pediatr Pulmonol;51(12):1382-1392, 2016 Dec.
[Is] ISSN:1099-0496
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: We sought to identify predictors of asthma development following severe early childhood RSV bronchiolitis. Different definitions of asthma were also compared. METHODS: This longitudinal, observational study (N = 343) followed patients (<2 years old) from a placebo-controlled trial (N = 979) of montelukast after RSV bronchiolitis to identify clinical, demographic, or biochemical predictors of asthma, atopic disorders, and chronic asthma therapy use at 6 years of age (Clinical Trials Registry Number: NCT01140048). Asthma (primary definition) was based on parental identification of wheeze at 6 AND 12 months before 6 years of age; definitions based on physician diagnosis as well as parental identification of wheeze at 6 OR 12 months (to consider seasonal effect) were also assessed. Post-hoc analyses evaluated agreement among asthma diagnosis criteria. RESULTS: Prevalence of asthma (primary definition by parental identification), asthma (physician diagnosis), atopic disorders, and chronic asthma therapy use (parental identification) was 6.1%, 22.4%, 36.2%, and 14.5%, respectively. Predictors for asthma (primary definition) included male gender, a relative with asthma, and RAST positive for dog dander; for physician diagnosis of asthma, high severity score for RSV bronchiolitis, high respiratory rate, and asthma diagnosis before enrollment. Predictors of atopic disorders included allergic rhinitis before enrollment, a relative with asthma, and the plasma biomarkers IL-5, IL-16, and IL-18. Predictors of chronic asthma therapy use included asthma diagnosis before enrollment and geographic region (Europe and Africa). Only 42% of patients with asthma (primary definition) also met the asthma definition by physician diagnosis and chronic asthma therapy use. CONCLUSION: Among children with early RSV bronchiolitis, hereditary factors (i.e., having a relative with asthma) and RSV bronchiolitis severity were predictors of asthma and atopic disorders at 6 years of age. Of interest, there was poor agreement among the asthma definitions evaluated. Pediatr Pulmonol. 2016;51:1382-1392. © 2016 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Asma/epidemiologia
Bronquiolite Viral/epidemiologia
Hipersensibilidade/epidemiologia
Infecções por Vírus Respiratório Sincicial/epidemiologia
[Mh] Termos MeSH secundário: Acetatos/uso terapêutico
Animais
Antiasmáticos/uso terapêutico
Asma/tratamento farmacológico
Asma/imunologia
Criança
Pré-Escolar
Alérgenos Animais/imunologia
Cães
Europa (Continente)
Feminino
Seres Humanos
Hipersensibilidade/imunologia
Hipersensibilidade Imediata/epidemiologia
Hipersensibilidade Imediata/imunologia
Lactente
Interleucina-16/imunologia
Interleucina-18/imunologia
Interleucina-5/imunologia
Estudos Longitudinais
Masculino
Anamnese
Prevalência
Estudos Prospectivos
Quinolinas/uso terapêutico
Taxa Respiratória
Sons Respiratórios
Rinite Alérgica/epidemiologia
Fatores de Risco
Índice de Gravidade de Doença
Fatores Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Acetates); 0 (Anti-Asthmatic Agents); 0 (IL5 protein, human); 0 (Interleukin-16); 0 (Interleukin-18); 0 (Interleukin-5); 0 (Quinolines); MHM278SD3E (montelukast)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160507
[St] Status:MEDLINE
[do] DOI:10.1002/ppul.23461


  5 / 27 MEDLINE  
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[PMID]:26808447
[Au] Autor:Goronfolah L
[Ad] Endereço:Department of Pediatrics - Allergy & Immunology, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Jeddah, Kingdom of Saudi Arabia. E-mail: loie6@hotmail.com.
[Ti] Título:Aeroallergens, atopy and allergic rhinitis in the Middle East.
[So] Source:Eur Ann Allergy Clin Immunol;48(1):5-21, 2016 Jan.
[Is] ISSN:1764-1489
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:The literature on the nature and prevalence of indoor and/or outdoor aeroallergens, atopy and symptoms of rhinitis and asthma in the Middle East region (defined here as Bahrain, Egypt, Iran, Iraq, Israel, Jordan, Kuwait, Lebanon, Oman, Palestine, Qatar, Kingdom of Saudi Arabia - KSA, Syria, United Arab Emirates and Yemen) was reviewed. Although documentation was poor in all countries other than Iran and the KSA, a wide range of "global" and "local" aeroallergens (grass, weed and tree pollens, fungal spores, insect allergens, dander, and house dust mites) has been observed across the region. The prevalence of current self-reported or parent-reported symptoms of rhinitis ranged from 9% to 38%. Researchers have suggested that the high atopy rates and self-reported rhinitis rates are associated with an on-going shift towards a "western" lifestyle.
[Mh] Termos MeSH primário: Alérgenos/imunologia
Hipersensibilidade Imediata/epidemiologia
Hipersensibilidade Imediata/imunologia
Rinite Alérgica/epidemiologia
Rinite Alérgica/imunologia
[Mh] Termos MeSH secundário: Animais
Alérgenos Animais/imunologia
Feminino
Seres Humanos
Insetos/imunologia
Masculino
Oriente Médio/epidemiologia
Pólen/imunologia
Prevalência
Pyroglyphidae/imunologia
Esporos Fúngicos/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Allergens)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160126
[St] Status:MEDLINE


  6 / 27 MEDLINE  
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[PMID]:26586036
[Au] Autor:Hosoki K; Boldogh I; Aguilera-Aguirre L; Sun Q; Itazawa T; Hazra T; Brasier AR; Kurosky A; Sur S
[Ad] Endereço:Department of Internal Medicine, Division of Allergy and Immunology, University of Texas Medical Branch, Galveston, Tex.
[Ti] Título:Myeloid differentiation protein 2 facilitates pollen- and cat dander-induced innate and allergic airway inflammation.
[So] Source:J Allergy Clin Immunol;137(5):1506-1513.e2, 2016 May.
[Is] ISSN:1097-6825
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The National Health and Nutrition Examination Survey identified several pollens and cat dander as among the most common allergens that induce allergic sensitization and allergic diseases. We recently reported that ragweed pollen extract (RWPE) requires Toll-like receptor 4 (TLR4) to stimulate CXCL-mediated innate neutrophilic inflammation, which in turn facilitates allergic sensitization and airway inflammation. Myeloid differentiation protein 2 (MD2) is a TLR4 coreceptor, but its role in pollen- and cat dander-induced innate and allergic inflammation has not been critically evaluated. OBJECTIVE: We sought to elucidate the role of MD2 in inducing pollen- and cat dander-induced innate and allergic airway inflammation. METHODS: TCM(Null) (TLR4(Null), CD14(Null), MD2(Null)), TLR4(Hi), and TCM(Hi) cells and human bronchial epithelial cells with small interfering RNA-induced downregulation of MD2 were stimulated with RWPE, other pollen allergic extracts, or cat dander extract (CDE), and activation of nuclear factor κB (NF-κB), secretion of the NF-κB-dependent CXCL8, or both were quantified. Wild-type mice or mice with small interfering RNA knockdown of lung MD2 were challenged intranasally with RWPE or CDE, and innate and allergic inflammation was quantified. RESULTS: RWPE stimulated MD2-dependent NF-κB activation and CXCL secretion. Likewise, Bermuda, rye, timothy, pigweed, Russian thistle, cottonwood, walnut, and CDE stimulated MD2-dependent CXCL secretion. RWPE and CDE challenge induced MD2-dependent and CD14-independent innate neutrophil recruitment. RWPE induced MD2-dependent allergic sensitization and airway inflammation. CONCLUSIONS: MD2 plays an important role in induction of allergic sensitization to cat dander and common pollens relevant to human allergic diseases.
[Mh] Termos MeSH primário: Alérgenos/imunologia
Alérgenos Animais/imunologia
Antígeno 96 de Linfócito/imunologia
Pólen/imunologia
Hipersensibilidade Respiratória/imunologia
[Mh] Termos MeSH secundário: Animais
Antígenos de Plantas/imunologia
Líquido da Lavagem Broncoalveolar/imunologia
Gatos/imunologia
Linhagem Celular
Citocinas/imunologia
Seres Humanos
Imunidade Inata
Pulmão/imunologia
Pulmão/metabolismo
Antígeno 96 de Linfócito/genética
Masculino
Camundongos Endogâmicos C57BL
Camundongos Knockout
Mucinas/metabolismo
NF-kappa B/imunologia
Extratos Vegetais/imunologia
RNA Mensageiro/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 0 (Antigens, Plant); 0 (Cytokines); 0 (Ly96 protein, mouse); 0 (Lymphocyte Antigen 96); 0 (Mucins); 0 (NF-kappa B); 0 (Plant Extracts); 0 (RNA, Messenger); 0 (ragweed pollen)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170614
[Lr] Data última revisão:
170614
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:151121
[St] Status:MEDLINE


  7 / 27 MEDLINE  
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[PMID]:26727772
[Au] Autor:Núñez-Acevedo B; Domínguez-Ortega J; Rodríguez-Jiménez B; Kindelan-Recarte C; Jimeno-Nogales L
[Ti] Título:Hedgehog Allergy: New Pet, Old Allergens.
[So] Source:J Investig Allergol Clin Immunol;25(5):376-7, 2015.
[Is] ISSN:1018-9068
[Cp] País de publicação:Spain
[La] Idioma:eng
[Mh] Termos MeSH primário: Animais Exóticos/imunologia
Alérgenos Animais/imunologia
Ouriços-Cacheiros/imunologia
Hipersensibilidade Respiratória/imunologia
[Mh] Termos MeSH secundário: Adulto
Alérgenos/imunologia
Animais
Feminino
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:160105
[Lr] Data última revisão:
160105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160106
[St] Status:MEDLINE


  8 / 27 MEDLINE  
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[PMID]:26059105
[Au] Autor:Bjerg A; Winberg A; Berthold M; Mattsson L; Borres MP; Rönmark E
[Ad] Endereço:Krefting Research Centre, Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, Göteborg, Sweden.
[Ti] Título:A population-based study of animal component sensitization, asthma, and rhinitis in schoolchildren.
[So] Source:Pediatr Allergy Immunol;26(6):557-63, 2015 Sep.
[Is] ISSN:1399-3038
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Animal sensitization is a major determinant of asthma in children. Component-resolved studies of unselected pediatric populations are lacking. The aim was to describe sensitization to animal components and the association with asthma and rhinitis in animal-sensitized schoolchildren. METHODS: A random sample of 696 children (11-12 years) from a Swedish population-based cohort was tested for sensitization to cat, dog, and horse dander using ImmunoCAP. Sera from animal-sensitized children were further analyzed by microarray including three allergen components from cat, four from dog, and two from horse. The parents completed an expanded ISAAC questionnaire. RESULTS: Of 259 animal-sensitized children (≥0.1 kUA /l), 51% were sensitized to all three, 23% to two, and 25% to one species. Current asthma and asthma symptoms following contact with cats were associated with co-sensitization to Fel d 1 and Fel d 4. This association was seen already at moderate-level sensitization (1-15 ISU) to Fel d 4, at which level most children were sensitized to Fel d 1, as well. In dog-sensitized children, the majority was sensitized to more than one dog component, and co-sensitization to Can f 5 and Can f 1/f 2 conferred the greatest risk for asthma. Sensitization to the highly cross-reactive serum albumins was uncommon and not associated with asthma. CONCLUSIONS: Among schoolchildren in northern Sweden, where mite allergy is uncommon, furry animals were the primary perennial sensitizers. Asthma was associated with higher levels of component sensitization, and sensitization to more than one component from the same animal conferred the greatest risk.
[Mh] Termos MeSH primário: Alérgenos/imunologia
Asma/imunologia
Alérgenos Animais/imunologia
Animais de Estimação/imunologia
Rinite Alérgica/imunologia
[Mh] Termos MeSH secundário: Fatores Etários
Alérgenos/efeitos adversos
Animais
Asma/sangue
Asma/diagnóstico
Biomarcadores/sangue
Gatos
Criança
Reações Cruzadas
Alérgenos Animais/efeitos adversos
Cães
Feminino
Glicoproteínas/imunologia
Cavalos
Seres Humanos
Imunoglobulina E/sangue
Masculino
Rinite Alérgica/sangue
Rinite Alérgica/diagnóstico
Fatores de Risco
Testes Sorológicos
Inquéritos e Questionários
Suécia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Allergens); 0 (Biomarkers); 0 (Fel d 4 allergen, Felis domesticus); 0 (Glycoproteins); 0 (allergen Can f 2); 0 (allergen Can f I); 37341-29-0 (Immunoglobulin E); G408EE88II (Fel d 1 protein, Felis domesticus)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150611
[St] Status:MEDLINE
[do] DOI:10.1111/pai.12422


  9 / 27 MEDLINE  
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[PMID]:25886946
[Au] Autor:Thomsen GF; Schlünssen V; Skadhauge LR; Malling TH; Sherson DL; Omland Ø; Sigsgaard T
[Ad] Endereço:Department of Occupational Medicine, Hospital of Southwest Denmark, Finsensgade 35, 6700, Esbjerg, Denmark. gert@leifi.dk.
[Ti] Título:Are allergen batch differences and the use of double skin prick test important?
[So] Source:BMC Pulm Med;15:33, 2015 Apr 09.
[Is] ISSN:1471-2466
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Skin prick tests (SPT) are widely used both in clinical diagnostics and in research. The standardization of allergen extracts is well documented to be crucial for the validity of SPT, whereas less emphasis has been placed on reproducibility and the SPT procedure itself. The objectives of this study are to clarify how the double skin prick test procedure influence the sensitivity and specificity of the test and to analyse the differences in weal size in skin prick tests between two batches of allergen extracts from the same vendor. METHODS: The association between rhinitis and SPT was assessed among 1135 persons from a general population sample. SPT was performed twice with 10 common aeroallergens. In a subsample of 90 persons SPT was performed simultaneously with five of the allergens using different batches. RESULTS: Thirty percent had at least one positive SPT. Among asthmatics this number was 62%. Only minor differences were seen between the sizes of two weals from the same batch. A second SPT with the same batch did not change the association between rhinitis and sensitization. When performing SPT with two different batches disagreement was observed in 2% (Birch) to 11% (Cat) of the subjects. CONCLUSIONS: Performing SPT twice with the same allergen batch does not enhance the validity of the test, and value of double testing can be questioned. Considerable differences in SPT response with different batches from the same manufacturer were observed. Thus inter batch differences in allergen extracts might be a source of variability.
[Mh] Termos MeSH primário: Alérgenos
Preparações Farmacêuticas/normas
Rinite Alérgica/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Alternaria
Animais
Artemisia
Betula
Gatos
Cladosporium
Alérgenos Animais
Cães
Feminino
Fungos
Cavalos
Seres Humanos
Masculino
Extratos Vegetais/normas
Poaceae
Pólen
Pyroglyphidae
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Testes Cutâneos/normas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Allergens); 0 (Pharmaceutical Preparations); 0 (Plant Extracts)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:150420
[Lr] Data última revisão:
150420
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150419
[St] Status:MEDLINE
[do] DOI:10.1186/s12890-015-0021-3


  10 / 27 MEDLINE  
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[PMID]:25492163
[Au] Autor:Celakovská J; Ettlerová K; Ettler K; Vanecková J; Bukac J
[Ad] Endereço:Department of Dermatology and Venereology, Faculty Hospital and Medical Faculty of Charles University, Hradec Králové, Czech Republic.
[Ti] Título:Sensitization to aeroallergens in atopic dermatitis patients: association with concomitant allergic diseases.
[So] Source:J Eur Acad Dermatol Venereol;29(8):1500-5, 2015 Aug.
[Is] ISSN:1468-3083
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: A few reports demonstrate the relationship between IgE sensitization to aeroallergens in atopic dermatitis (AD) patients and other allergic diseases and parameters. OBJECTIVES: The objective of this study was to evaluate, if there is a significant relationship between the sensitization to common aeroallergens in AD patients and the occurrence of asthma bronchiale, rhinitis and other atopic parameters. METHODS: Sensitization to dust, mites, animal dander and bird feather was examined (skin prick test, specific IgE) and the relationship with the occurrence of asthma bronchiale, rhinitis, duration of AD, family history and onset of AD was evaluated. RESULTS: Two hundred and eighty-eight patients were examined - 90 men and 198 women. According to our results, IgE sensitization to animal dander, dust and mites may increase the risk of developing asthma or rhinitis. Persistent lesions of AD occur more often in patients with sensitization to animal dander, mites and dust. Patients with the sensitization to bird feather have the onset of AD more often above 5 years of age and in these patients, there is no relationship with the positive data about atopy in the family history. CONCLUSION: There is a greater likelihood of developing other allergic diseases in atopic dermatitis patients who suffer from sensitisation to animal dander, mites, and dust. Thus, prompt management of atopic dermatitis and allergy to inhallant allergens that develop in early infancy may be a successful method for preventing of atopic march.
[Mh] Termos MeSH primário: Alérgenos/imunologia
Alérgenos Animais/imunologia
Dermatite Atópica/imunologia
Poeira/imunologia
Plumas/imunologia
Hipersensibilidade/imunologia
Imunoglobulina E/imunologia
Ácaros/imunologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Ar
Animais
Dermatite Atópica/complicações
Feminino
Seres Humanos
Hipersensibilidade/complicações
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 0 (Dust); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:150716
[Lr] Data última revisão:
150716
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141211
[St] Status:MEDLINE
[do] DOI:10.1111/jdv.12891



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