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[PMID]:29223274
[Au] Autor:Roeder NL; Marshall JD; Britto CJ
[Ad] Endereço:Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT. Electronic address: nicole.roeder@yale.edu.
[Ti] Título:A Woman in Her 60s With Lung Adenocarcinoma Presents With Copious Watery Sputum and Respiratory Failure.
[So] Source:Chest;152(6):e143-e146, 2017 12.
[Is] ISSN:1931-3543
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CASE PRESENTATION: A woman in her 60s presented with 1 month of progressive dyspnea, watery rhinorrhea, and paroxysmal cough productive of clear, watery sputum. She was diagnosed with epidermal growth factor receptor (EGFR) mutation-positive lung adenocarcinoma at another institution 1 week prior to presentation and 3 weeks after the onset of symptoms. She was a never-smoker. She denied fevers and had completed a course of antibiotics for presumed pneumonia, without clinical improvement. She presented to the hospital due to increasing severity of her shortness of breath.
[Mh] Termos MeSH primário: Adenocarcinoma/diagnóstico
Neoplasias Pulmonares/diagnóstico
Insuficiência Respiratória/etiologia
Escarro/química
[Mh] Termos MeSH secundário: Adenocarcinoma/complicações
Lavagem Broncoalveolar
Diagnóstico Diferencial
Feminino
Seres Humanos
Neoplasias Pulmonares/complicações
Meia-Idade
Radiografia Torácica
Insuficiência Respiratória/diagnóstico
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171211
[St] Status:MEDLINE


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[PMID]:29268637
[Au] Autor:Melani AS; Lanzarone N; Rottoli P
[Ad] Endereço:a Fisiopatologia e Riabilitazione Respiratoria, Dipartimento Vasi, Cuore e Torace, Policlinico Le Scotte , Azienda Ospedaliera Universitaria Senese , Siena , Italy.
[Ti] Título:The pharmacological treatment of bronchiectasis.
[So] Source:Expert Rev Clin Pharmacol;11(3):245-258, 2018 Mar.
[Is] ISSN:1751-2441
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Until recently considered as a minor health problem, the role of bronchiectasis is now increasingly recognized. New specific drugs are being approved for treatment of bronchiectasis. Possibly they will offer better perspectives to bronchiectatic subjects with evolving course. Areas covered: We provide an overview of aetiopathogenesis, clinics and non-pharmacological management, extending the topic of pharmacological treatment. Present therapies were extrapolated from other chronic lung diseases, but newer promising specific drugs are being awaited. Therapy aims at improving mobilisation of bronchial secretions and, if any, reversing airflow obstruction. Antibiotics are indicated to treat exacerbations, eradicate or reduce sputum bacterial load. Expert commentary: Over the last years evidence is mounted that bronchiectatic subjects with accelerated course of disease should be referred to secondary and tertiary centres. This requires increased awareness on the role and the frequency of bronchiectasis in primary care. Long-term continuous or cyclical use of antibiotics is recommended to stabilize or improve the course of evolving disease. Macrolides are a currently preferred option. Inhaled antibiotics are gaining importance and are the object of ongoing research interest. Practical challenges of inhaled antibiotic treatment remain the need of defining the best therapeutic regimen and optimizing true adherence.
[Mh] Termos MeSH primário: Antibacterianos/administração & dosagem
Bronquiectasia/tratamento farmacológico
Desenho de Drogas
[Mh] Termos MeSH secundário: Administração por Inalação
Obstrução das Vias Respiratórias/tratamento farmacológico
Obstrução das Vias Respiratórias/etiologia
Bronquiectasia/microbiologia
Bronquiectasia/patologia
Seres Humanos
Macrolídeos/administração & dosagem
Adesão à Medicação
Escarro
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Macrolides)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171223
[St] Status:MEDLINE
[do] DOI:10.1080/17512433.2018.1421064


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[PMID]:29357378
[Au] Autor:Law YN; Jian H; Lo NWS; Ip M; Chan MMY; Kam KM; Wu X
[Ad] Endereço:Hong Kong Applied Science & Technology Research Institute Co., Ltd. (ASTRI), Hong Kong SAR, China.
[Ti] Título:Low cost automated whole smear microscopy screening system for detection of acid fast bacilli.
[So] Source:PLoS One;13(1):e0190988, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In countries with high tuberculosis (TB) burden, there is urgent need for rapid, large-scale screening to detect smear-positive patients. We developed a computer-aided whole smear screening system that focuses in real-time, captures images and provides diagnostic grading, for both bright-field and fluorescence microscopy for detection of acid-fast-bacilli (AFB) from respiratory specimens. OBJECTIVES: To evaluate the performance of dual-mode screening system in AFB diagnostic algorithms on concentrated smears with auramine O (AO) staining, as well as direct smears with AO and Ziehl-Neelsen (ZN) staining, using mycobacterial culture results as gold standard. METHODS: Adult patient sputum samples requesting for M. tuberculosis cultures were divided into three batches for staining: direct AO-stained, direct ZN-stained and concentrated smears AO-stained. All slides were graded by an experienced microscopist, in parallel with the automated whole smear screening system. Sensitivity and specificity of a TB diagnostic algorithm in using the screening system alone, and in combination with a microscopist, were evaluated. RESULTS: Of 488 direct AO-stained smears, 228 were culture positive. These yielded a sensitivity of 81.6% and specificity of 74.2%. Of 334 direct smears with ZN staining, 142 were culture positive, which gave a sensitivity of 70.4% and specificity of 76.6%. Of 505 concentrated smears with AO staining, 250 were culture positive, giving a sensitivity of 86.4% and specificity of 71.0%. To further improve performance, machine grading was confirmed by manual smear grading when the number of AFBs detected fell within an uncertainty range. These combined results gave significant improvement in specificity (AO-direct:85.4%; ZN-direct:85.4%; AO-concentrated:92.5%) and slight improvement in sensitivity while requiring only limited manual workload. CONCLUSION: Our system achieved high sensitivity without substantially compromising specificity when compared to culture results. Significant improvement in specificity was obtained when uncertain results were confirmed by manual smear grading. This approach had potential to substantially reduce workload of microscopists in high burden countries.
[Mh] Termos MeSH primário: Automação
Custos e Análise de Custo
Microscopia/métodos
Mycobacterium tuberculosis/isolamento & purificação
[Mh] Termos MeSH secundário: Seres Humanos
Microscopia/economia
Microscopia de Fluorescência
Escarro/microbiologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; VALIDATION STUDIES
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180123
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190988


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[PMID]:28464818
[Au] Autor:Weidner J; Jarenbäck L; de Jong K; Vonk JM; van den Berge M; Brandsma CA; Boezen HM; Sin D; Bossé Y; Nickle D; Ankerst J; Bjermer L; Postma DS; Faiz A; Tufvesson E
[Ad] Endereço:Respiratory Medicine and Allergology, Department of Clinical Sciences Lund, BMC, D12, Lund University, Skåne University Hospital, 221 84, Lund, Sweden.
[Ti] Título:Sulfatase modifying factor 1 (SUMF1) is associated with Chronic Obstructive Pulmonary Disease.
[So] Source:Respir Res;18(1):77, 2017 May 02.
[Is] ISSN:1465-993X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: It has been observed that mice lacking the sulfatase modifying factor (Sumf1) developed an emphysema-like phenotype. However, it is unknown if SUMF1 may play a role in Chronic Obstructive Pulmonary Disease (COPD) in humans. The aim was to investigate if the expression and genetic regulation of SUMF1 differs between smokers with and without COPD. METHODS: SUMF1 mRNA was investigated in sputum cells and whole blood from controls and COPD patients (all current or former smokers). Expression quantitative trait loci (eQTL) analysis was used to investigate if single nucleotide polymorphisms (SNPs) in SUMF1 were significantly associated with SUMF1 expression. The association of SUMF1 SNPs with COPD was examined in a population based cohort, Lifelines. SUMF1 mRNA from sputum cells, lung tissue, and lung fibroblasts, as well as lung function parameters, were investigated in relation to genotype. RESULTS: Certain splice variants of SUMF1 showed a relatively high expression in lung tissue compared to many other tissues. SUMF1 Splice variant 2 and 3 showed lower levels in sputum cells from COPD patients as compared to controls. Twelve SNPs were found significant by eQTL analysis and overlapped with the array used for genotyping of Lifelines. We found alterations in mRNA expression in sputum cells and lung fibroblasts associated with SNP rs11915920 (top hit in eQTL), which validated the results of the lung tissue eQTL analysis. Of the twelve SNPs, two SNPs, rs793391 and rs308739, were found to be associated with COPD in Lifelines. The SNP rs793391 was also confirmed to be associated with lung function changes. CONCLUSIONS: We show that SUMF1 expression is affected in COPD patients compared to controls, and that SNPs in SUMF1 are associated with an increased risk of COPD. Certain COPD-associated SNPs have effects on either SUMF1 gene expression or on lung function. Collectively, this study shows that SUMF1 is associated with an increased risk of developing COPD.
[Mh] Termos MeSH primário: Polimorfismo de Nucleotídeo Único/genética
Doença Pulmonar Obstrutiva Crônica/epidemiologia
Doença Pulmonar Obstrutiva Crônica/genética
Fumar/epidemiologia
Fumar/genética
Sulfatases/sangue
Sulfatases/genética
[Mh] Termos MeSH secundário: Idoso
Biomarcadores/sangue
Feminino
Estudos de Associação Genética
Marcadores Genéticos/genética
Predisposição Genética para Doença/genética
Seres Humanos
Masculino
Prevalência
Doença Pulmonar Obstrutiva Crônica/metabolismo
Reprodutibilidade dos Testes
Fatores de Risco
Sensibilidade e Especificidade
Fumar/metabolismo
Escarro/metabolismo
Suécia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Genetic Markers); EC 3.1.6.- (SUMF1 protein, human); EC 3.1.6.- (Sulfatases)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1186/s12931-017-0562-5


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[PMID]:29172708
[Au] Autor:Tang L; Feng S; Gao R; Han C; Sun X; Bao Y; Zhang W
[Ad] Endereço:1 Department of Orthopedics, Tianjin Medical University General Hospital , Tianjin City, China .
[Ti] Título:A Comparative Study on the Role of Xpert MTB/RIF in Testing Different Types of Spinal Tuberculosis Tissue Specimens.
[So] Source:Genet Test Mol Biomarkers;21(12):722-726, 2017 Dec.
[Is] ISSN:1945-0257
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:AIMS: The aim of the present study was to compare the efficacy of the commercial Xpert Mycobacterium tuberculosis/rifampin (MTB/RIF) test for evaluating different types of spinal tuberculosis (TB) tissue specimens. METHODS: Pus, granulation tissue, and caseous necrotic tissue specimens from 223 patients who were diagnosed with spinal TB and who underwent curettage were collected for bacterial culture and the Xpert MTB/RIF assay to calculate the positive rate. Bacterial culture and phenotypic drug sensitivity testing (pDST) were adopted as the gold standards to calculate the sensitivity and specificity of the Xpert bacterial detection and drug resistance (DR) test. RESULTS: The positive rate (68.61% ± 7.35%) from the Xpert MTB/RIF assays of spinal TB patients' tissue specimens was higher compared with bacterial culture (44.39% ± 6.51%, Z = 5.1642, p < 0.01), and the positive rates from Xpert MTB/RIF assays on the three types of specimens were all higher than those of bacterial culture, with statistically significant results for pus and granulation tissue specimens. The positive rates for pus using the two bacteriological tests were higher than those for granulation tissue but were not statistically significant. However, the positive rates obtained from granulation tissue were statistically significantly higher than those obtained from caseous necrotic tissue. With bacterial culture and pDST as the gold standards, the sensitivity of Xpert MTB/RIF assays for MTB was 96.97%, while the sensitivity and specificity of the DR test also remained relatively high. CONCLUSION: For efficient and accurate diagnosis of spinal TB and DR and timely provision of effective treatment, multiple specimens, especially the pus of spinal TB patients, should be collected for Xpert MTB/RIF assays.
[Mh] Termos MeSH primário: Técnicas de Diagnóstico Molecular/métodos
Tuberculose da Coluna Vertebral/diagnóstico
[Mh] Termos MeSH secundário: China
Farmacorresistência Bacteriana
Feminino
Seres Humanos
Masculino
Mycobacterium tuberculosis/patogenicidade
Rifampina/farmacologia
Sensibilidade e Especificidade
Escarro
Tuberculose Pulmonar/diagnóstico
Tuberculose Pulmonar/microbiologia
Tuberculose da Coluna Vertebral/microbiologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
VJT6J7R4TR (Rifampin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1089/gtmb.2017.0149


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[PMID]:29381919
[Au] Autor:Grandjean Lapierre S; Phelippeau M; Hakimi C; Didier Q; Reynaud-Gaubert M; Dubus JC; Drancourt M
[Ad] Endereço:Aix-Marseille Université, URMITE Méditerranée Infection.
[Ti] Título:Cystic fibrosis respiratory tract salt concentration: An Exploratory Cohort Study.
[So] Source:Medicine (Baltimore);96(47):e8423, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In cystic fibrosis patients, electrolytic and osmolality imbalance secondary to cystic fibrosis transmembrane conductance regulator mutations may impact on mucoid secretion accumulation and secondary colonization by opportunistic pathogens such as nontuberculous mycobacteria.We performed a noninvasive exploratory prospective controlled clinical study comparing sputum salinity and acid-base characteristics of cystic fibrosis and noncystic fibrosis control patients. A total of 57 patients and 62 controls were included.Sputum salt concentrations were 10.5 g/L (95% CI: 7.7-13.3) in patients and 7.4 g/L (95% CI: 5.9-8.9) in aged-matched controls, a difference that was found to be statistically significant (P < .05). No difference in pH was observed between patients and controls.These differences in respiratory secretions salt concentrations could influence host-pathogen interactions in the context of cystic fibrosis respiratory infections. We propose to include respiratory secretion salt measurement as a routine analysis on cystic fibrosis patients' sputum submitted for bacterial culture.
[Mh] Termos MeSH primário: Fibrose Cística/patologia
Cloreto de Sódio/análise
Escarro/química
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Concentração de Íons de Hidrogênio
Masculino
Meia-Idade
Estudos Prospectivos
Sistema Respiratório
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
451W47IQ8X (Sodium Chloride)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008423


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[PMID]:29390519
[Au] Autor:Wu X; Wang Y; Weng T; Hu C; Wang FXC; Wu Z; Yu D; Lu H; Yao H
[Ad] Endereço:State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou.
[Ti] Título:Preparation of immunochromatographic strips for rapid detection of early secreted protein ESAT-6 and culture filtrate protein CFP-10 from Mycobacterium tuberculosis.
[So] Source:Medicine (Baltimore);96(51):e9350, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The early secreted protein early secretory antigenic target 6(ESAT-6) and the culture filtrate protein 10 (CFP-10) are 2 antigens that are specific to Mycobacterium tuberculosis. These 2 antigens are good targets for tuberculosis (TB) detection.To rapidly diagnose TB across a variety of samples, we developed colloidal gold immunochromatographic strips (ICSs) based on ESAT-6 and CFP-10.The strips were evaluated using 233 samples, including sputum, plasma, and pleural effusion samples.The positive detection rates for ICSs for ESAT-6 and CFP-10 in sputum (culture-positive for M tuberculosis) were 100% and 91.2%, respectively. The positive detection rates for ICSs for ESAT-6 and CFP-10 in plasma were 34.1% and 29.4%, respectively. The positive detection rates for ICSs for ESAT-6 and CFP-10 in pleural effusion were 64.7% and 55.9%, respectively. Experimental analysis of culture supernatant showing that the ICS developed for ESAT-6 had a sensitivity of 100% and a specificity of 91.2%. While the ICS developed for CFP-10 had a sensitivity of 91.2% and a specificity of 88.2%.The validity of the test is limited by source of sample. The technique is sensitive and specific for samples in sputum and culture media but not for plasma or pleural effusion samples. Detection of M tuberculosis using ICSs is rapid, simple, and relatively effective; thus, ICSs are a potential screening tool for TB.
[Mh] Termos MeSH primário: Antígenos de Bactérias/metabolismo
Proteínas de Bactérias/metabolismo
Mycobacterium tuberculosis/imunologia
Mycobacterium tuberculosis/metabolismo
Tuberculose/diagnóstico
[Mh] Termos MeSH secundário: Proteínas de Bactérias/secreção
Técnicas Bacteriológicas
Distribuição de Qui-Quadrado
Ensaio de Imunoadsorção Enzimática/métodos
Seres Humanos
Imunocromatografia/métodos
Reação em Cadeia da Polimerase/métodos
Amostragem
Sensibilidade e Especificidade
Escarro/microbiologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Bacterial); 0 (Bacterial Proteins); 0 (CFP-10 protein, Mycobacterium tuberculosis); 0 (ESAT-6 protein, Mycobacterium tuberculosis)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009350


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Texto completo SciELO Saúde Pública
[PMID]:28453114
[Au] Autor:Leal-Bohórquez AF; Castro-Osorio CM; Wintaco-Martínez LM; Villalobos R; Puerto-Castro GM
[Ad] Endereço:Instituto Nacional de Salud. Bogotá. Colombia. andres_leal@yahoo.com; ccastro@ins.gov.co; mairawm@hotmail.com; gpuerto@ins.gov.co.
[Ti] Título:[Tuberculosis caused by Mycobacterium bovis in workers of bovine tuberculosis sanitation farms in Antioquia, Boyacá and Cundinamarca].
[Ti] Título:Tuberculosis por Mycobacterium bovis en trabajadores de fincas en saneamiento para tuberculosis bovina, de Antioquia, Boyacá y Cundinamarca..
[So] Source:Rev Salud Publica (Bogota);18(5):727-737, 2016 Sep-Oct.
[Is] ISSN:0124-0064
[Cp] País de publicação:Colombia
[La] Idioma:spa
[Ab] Resumo:Objective: To perform classic and molecular epidemiological surveillance of human tuberculosis caused by Mycobacterium bovis in bovine supply chains at farms with PPD positive bovines in the departments of Antioquia, Boyacá and Cundinamarca during a one-year period. Methods: Livestock farms with PPD positive bovines or buffalos were visited in the study departments according to information obtained in the "Programa Nacional de Tuberculosis bovina" (National program on bovine Tuberculosis) released by ICA (Colombian Agriculture and Livestock Institute). Data on socio-demographic information and tuberculosis risk factors associated to the occupation were collected through a survey applied to all workers at the visited farms. Sputum samples were obtained after informed consent. The sputa underwent microbiological and molecular testing to identify members of the M. tuberculosis complex. Results : Thirty-three livestock farms were visited and information of 164 workers from the bovine supply chain was collected. Staying in a PPD positive farm for more than a year, ignorance about the disease and the presence of possible vectors, like dogs and cats, were identified as possible risk factors for developing tuberculosis. No cases of tuberculosis caused by M. bovis or M. tuberculosis in workers of the visited farms were found. Conclusion : No cases of the disease caused by this zoonotic agent were documented in the departments of Antioquia, Boyacá and Cundinamarca.
[Mh] Termos MeSH primário: Doenças dos Trabalhadores Agrícolas/microbiologia
Criação de Animais Domésticos
Fazendas
Mycobacterium bovis
Tuberculose/microbiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Doenças dos Trabalhadores Agrícolas/diagnóstico
Animais
Gatos
Bovinos
Colômbia
Vetores de Doenças
Cães
Escolaridade
Seres Humanos
Meia-Idade
Mycobacterium tuberculosis
Saneamento
Escarro/microbiologia
Tuberculose/diagnóstico
Tuberculose Bovina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


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[PMID]:27776592
[Au] Autor:Izumi K; Kawatsu L; Ohkado A; Uchimura K; Kato S
[Ad] Endereço:Department of Epidemiology and Clinical Research, Research Institute of Tuberculosis (RIT), Japan Anti-Tuberculosis Association (JATA), Tokyo, Japan; Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
[Ti] Título:Evaluating the impact of health resource reconstruction on improving spatial accessibility of tuberculosis care.
[So] Source:Int J Tuberc Lung Dis;20(11):1501-1508, 2016 Nov.
[Is] ISSN:1815-7920
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:SETTING: In Japan, a decline in tuberculosis (TB) notification rates and shortening of duration of hospitalisation have led to a drastic decrease in the number of hospital beds for TB patients (TB beds), causing severe undersupply in certain regions. OBJECTIVE: To assess the current status of spatial access to TB beds in Japan and evaluate the potential impact of health resource reconstruction in mitigating undersupply of TB beds. DESIGN: A cross-sectional study was conducted whereby a two-step floating catchment area (2SFCA) method was used to calculate an 'accessibility score' to evaluate spatial accessibility of TB beds in the regions classified by four levels of urbanisation. The impact of introducing 'potential TB beds' was assessed via the changes in the proportion of undersupplied regions and TB patients notified from undersupplied regions. RESULTS: Undersupplied regions were characterised by 'very low', 'low' and 'moderate' level of urbanisation. By introducing 'potential TB beds', the proportion of both undersupplied regions and TB patients could be significantly reduced, especially in less urbanised regions. CONCLUSION: Our results may be used to guide future decision-making over resource allocation of TB care in Japan. The 2SFCA method may be applied to other countries using appropriate demand and supply variables.
[Mh] Termos MeSH primário: Recursos em Saúde/normas
Acesso aos Serviços de Saúde/normas
Tuberculose/epidemiologia
Tuberculose/terapia
[Mh] Termos MeSH secundário: Estudos Transversais
Tomada de Decisões
Hospitalização
Seres Humanos
Japão/epidemiologia
Escarro/microbiologia
Teste Tuberculínico
Tuberculose/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


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[PMID]:29195767
[Au] Autor:Lü Y; Liu W; Liang H; Zhao S; Zhang W; Liu J; Jin C; Hu H
[Ad] Endereço:State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
[Ti] Título:NDM-1 encoded by a pNDM-HN380-like plasmid pNDM-BJ03 in clinical Enterobacter cloacae.
[So] Source:Diagn Microbiol Infect Dis;90(2):153-155, 2018 Feb.
[Is] ISSN:1879-0070
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A carbapenemase-producing Enterobacter cloacae hhy03 with a bla and bla -coharboring plasmid was isolated from a sputum specimen of a patient. This is the third nucleotide sequence report of bla -harboring plasmid from Enterobacter cloacae that have caused lethal infections in China, indicating the spread of NDM-1 by IncX3 plasmid between Enterobacteriaceae.
[Mh] Termos MeSH primário: Enterobacter cloacae/efeitos dos fármacos
Enterobacter cloacae/genética
Infecções por Enterobacteriaceae/microbiologia
Plasmídeos/genética
beta-Lactamases/genética
[Mh] Termos MeSH secundário: Idoso
Antibacterianos/farmacologia
Proteínas de Bactérias/genética
China
Enterobacter cloacae/enzimologia
Seres Humanos
Lactente
Klebsiella pneumoniae/genética
Masculino
Testes de Sensibilidade Microbiana
Escarro/microbiologia
Resistência beta-Lactâmica/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Bacterial Proteins); EC 3.5.2.6 (beta-Lactamases); EC 3.5.2.6 (beta-lactamase NDM-1); EC 3.5.2.6 (carbapenemase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171203
[St] Status:MEDLINE



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