Base de dados : MEDLINE
Pesquisa : A12.207.152 [Categoria DeCS]
Referências encontradas : 33499 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 3350 ir para página                         

  1 / 33499 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29364955
[Au] Autor:Harm S; Schildböck C; Hartmann J
[Ad] Endereço:Department for Health Sciences and Biomedicine, Danube University Krems, Krems, Austria.
[Ti] Título:Removal of stabilizers from human serum albumin by adsorbents and dialysis used in blood purification.
[So] Source:PLoS One;13(1):e0191741, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Human serum albumin (HSA) is a monomeric multi-domain protein that possesses an extraordinary binding capacity. It plays an important role in storing and transporting endogenous substances, metabolites, and drugs throughout the human circulatory system. Clinically, HSA is used to treat a variety of diseases such as hypovolemia, shock, burns, hemorrhage, and trauma in critically ill patients. Pharmaceutical-grade HSA contains the stabilizers sodium caprylate and N-acetyltryptophanate to protect the protein from oxidative stress and to stabilize it for heat treatment which is applied for virus inactivation. MATERIAL AND METHODS: The aim of this study was to determine if the two stabilizers can be depleted by adsorbent techniques. Several, adsorbents, some of them are in clinical use, were tested in batch and in a dynamic setup for their ability to remove the stabilizers. Furthermore, the removal of the stabilizers was tested using a pediatric high flux dialyzer. RESULTS: The outcome of this study shows that activated charcoal based adsorbents are more effective in removal of N-acetylthryptophanate, whereas polystyrene based adsorbents are better for the removal of caprylate from HSA solutions. An adsorbent cartridge which contains a mix of activated charcoal and polystyrene based material could be used to remove both stabilizers effectively. After 4 hours treatment with a high flux dialyzer, N-acetyltryptophanate was totally removed whereas 20% of caprylate remained in the HSA solution.
[Mh] Termos MeSH primário: Sangue
Diálise/métodos
Albumina Sérica/química
[Mh] Termos MeSH secundário: Adsorção
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Serum Albumin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191741


  2 / 33499 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28456430
[Au] Autor:Seiringer P; Pritsch M; Flores-Chavez M; Marchisio E; Helfrich K; Mengele C; Hohnerlein S; Bretzel G; Löscher T; Hoelscher M; Berens-Riha N
[Ad] Endereço:Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich (LMU), Leopoldstr. 5, 80802 Munich, Germany; German Center for Infection Research (DZIF), partner site Munich, Munich, Germany. Electronic address: peter.seiringer@lrz.uni-muenchen.de.
[Ti] Título:Comparison of four PCR methods for efficient detection of Trypanosoma cruzi in routine diagnostics.
[So] Source:Diagn Microbiol Infect Dis;88(3):225-232, 2017 Jul.
[Is] ISSN:1879-0070
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Due to increased migration, Chagas disease has become an international health problem. Reliable diagnosis of chronically infected people is crucial for prevention of non-vectorial transmission as well as treatment. This study compared four distinct PCR methods for detection of Trypanosoma cruzi DNA for the use in well-equipped routine diagnostic laboratories. DNA was extracted of T. cruzi-positive and negative patients' blood samples and cultured T. cruzi, T. rangeli as well as Leishmania spp. One conventional and two real-time PCR methods targeting a repetitive Sat-DNA sequence as well as one conventional PCR method targeting the variable region of the kDNA minicircle were compared for sensitivity, intra- and interassay precision, limit of detection, specificity and cross-reactivity. Considering the performance, costs and ease of use, an algorithm for PCR-diagnosis of patients with a positive serology for T. cruzi antibodies was developed.
[Mh] Termos MeSH primário: Doença de Chagas/diagnóstico
Técnicas de Diagnóstico Molecular/métodos
Reação em Cadeia da Polimerase/métodos
Trypanosoma cruzi/isolamento & purificação
[Mh] Termos MeSH secundário: Adolescente
Adulto
Sangue/parasitologia
Pré-Escolar
Feminino
Seres Humanos
Masculino
Meia-Idade
Sensibilidade e Especificidade
Trypanosoma cruzi/genética
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE


  3 / 33499 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29188665
[Au] Autor:Zou KN; Hu M; Huang JP; Zhou HG
[Ad] Endereço:Shanghai Key Laboratory of Crime Scene Evidence, Key Laboratory of Forensic Evidence and Science Technology, Ministry of Public Security, Institute of Forensic Science, Shanghai Public Security Bureau, Shanghai 200083, China.
[Ti] Título:[Identification of Vaginal Fluid Using Microbial Signatures].
[So] Source:Fa Yi Xue Za Zhi;32(4):254-256, 2016 Aug.
[Is] ISSN:1004-5619
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVES: To investigate the specific microbial signatures in vaginal fluid. METHODS: Vaginal fluid (16 samples), saliva (16 samples), feces (16 samples), semen (8 samples), peripheral blood (8 samples), urine (5 samples), and nasal secretion (4 samples) were collected respectively. The genes of , , , , and were amplified. PCR production was detected via a 3130xl Genetic Analyzer. RESULTS: The detected number of , , , , and were 15, 5, 8, 14, and 3 in all vaginal fluid samples, respectively. and existed specifically in vaginal fluid. CONCLUSIONS: There is a potential application value to detect and for the identification of vaginal fluid.
[Mh] Termos MeSH primário: Líquidos Corporais/microbiologia
Vagina/microbiologia
[Mh] Termos MeSH secundário: Actinobacteria/classificação
Sangue/microbiologia
Fezes/microbiologia
Feminino
Genes Bacterianos
Seres Humanos
Lactobacillus/classificação
Cavidade Nasal/microbiologia
Reação em Cadeia da Polimerase
RNA Ribossômico 16S/genética
Saliva/microbiologia
Sêmen/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Ribosomal, 16S)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.3969/j.issn.1004-5619.2016.04.004


  4 / 33499 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29324798
[Au] Autor:Gookin JL; Mathews KG; Cullen J; Seiler G
[Ad] Endereço:Department of Clinical Sciences, College of Veterinary Medicine and Comparative Medicine Institute, North Carolina State University, Raleigh, North Carolina, United States of America.
[Ti] Título:Qualitative metabolomics profiling of serum and bile from dogs with gallbladder mucocele formation.
[So] Source:PLoS One;13(1):e0191076, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mucocele formation is characterized by secretion of abnormally thick mucus by the gallbladder epithelium of dogs that may cause obstruction of the bile duct or rupture of the gallbladder. The disease is increasingly recognized and is associated with a high morbidity and mortality. The cause of gallbladder mucocele formation in dogs is unknown. There is a strong breed predisposition and affected dogs have a high incidence of concurrent endocrinopathy or hyperlipidemia. These observations suggest a significant influence of both genetic and metabolic factors on disease pathogenesis. In this study, we investigated a theory that mucocele formation is associated with a syndrome of metabolic disruption. We surmised that a global, untargeted metabolomics approach could provide unique insight into the systemic pathogenesis of gallbladder mucocele formation and identify specific compounds as candidate biomarkers or treatment targets. Moreover, concurrent examination of the serum and hepatic duct bile metabolome would enable the construction of mechanism-based theories or identification of specific compounds responsible for altered function of the gallbladder epithelium. Abnormalities observed in dogs with gallbladder mucocele formation, including a 33-fold decrease in serum adenosine 5'-monophosphate (AMP), lower quantities of precursors required for synthesis of energy transporting nucleotides, and increases in citric acid cycle intermediates, suggest excess metabolic energy and a carbon surplus. Altered quantities of compounds involved in protein translation and RNA turnover, together with accumulation of gamma-glutamylated and N-acetylated amino acids in serum suggest abnormal regulation of protein and amino acid metabolism. Increases in lathosterol and 7α-hydroxycholesterol suggest a primary increase in cholesterol synthesis and diversion to bile acid formation. A number of specific biomarker compounds were identified for their ability to distinguish between control dogs and those that formed a gallbladder mucocele. Particularly noteworthy was a significant decrease in quantity of biologically active compounds that stimulate biliary ductal fluid secretion including adenosine, cAMP, taurolithocholic acid, and taurocholic acid. These findings support the presence of significant metabolic disruption in dogs with mucocele formation. A targeted, quantitative analysis of the identified serum biomarkers is warranted to determine their utility for diagnosis of this disease. Finally, repletion of compounds whose biological activity normally promotes biliary ductal secretion should be examined for any therapeutic impact for resolution or prevention of mucocele formation.
[Mh] Termos MeSH primário: Bile/metabolismo
Sangue
Doenças da Vesícula Biliar/metabolismo
Metabolômica
Mucocele/metabolismo
[Mh] Termos MeSH secundário: Animais
Cães
Feminino
Doenças da Vesícula Biliar/sangue
Masculino
Mucocele/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191076


  5 / 33499 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29346441
[Au] Autor:Gifford SC; Strachan BC; Xia H; Vörös E; Torabian K; Tomasino TA; Griffin GD; Lichtiger B; Aung FM; Shevkoplyas SS
[Ad] Endereço:Halcyon Biomedical Incorporated, Friendswood, Texas, United States of America.
[Ti] Título:A portable system for processing donated whole blood into high quality components without centrifugation.
[So] Source:PLoS One;13(1):e0190827, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The use of centrifugation-based approaches for processing donated blood into components is routine in the industrialized world, as disparate storage conditions require the rapid separation of 'whole blood' into distinct red blood cell (RBC), platelet, and plasma products. However, the logistical complications and potential cellular damage associated with centrifugation/apheresis manufacturing of blood products are well documented. The objective of this study was to evaluate a proof-of-concept system for whole blood processing, which does not employ electromechanical parts, is easily portable, and can be operated immediately after donation with minimal human labor. METHODS AND FINDINGS: In a split-unit study (n = 6), full (~500mL) units of freshly-donated whole blood were divided, with one half processed by conventional centrifugation techniques and the other with the new blood separation system. Each of these processes took 2-3 hours to complete and were performed in parallel. Blood products generated by the two approaches were compared using an extensive panel of cellular and plasma quality metrics. Comparison of nearly all RBC parameters showed no significant differences between the two approaches, although the portable system generated RBC units with a slight but statistically significant improvement in 2,3-diphosphoglyceric acid concentration (p < 0.05). More notably, several markers of platelet damage were significantly and meaningfully higher in products generated with conventional centrifugation: the increase in platelet activation (assessed via P-selectin expression in platelets before and after blood processing) was nearly 4-fold higher for platelet units produced via centrifugation, and the release of pro-inflammatory mediators (soluble CD40-ligand, thromboxane B2) was significantly higher for centrifuged platelets as well (p < 0.01). CONCLUSION: This study demonstrated that a simple, passive system for separating donated blood into components may be a viable alternative to centrifugation-particularly for applications in remote or resource-limited settings, or for patients requiring highly functional platelet product.
[Mh] Termos MeSH primário: Doadores de Sangue
Sangue
Manejo de Espécimes
[Mh] Termos MeSH secundário: Centrifugação
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180119
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190827


  6 / 33499 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28454765
[Au] Autor:Su S; Ren Y; Shi C; Zhang X; Ji JX; Zhang Y; Liu X; Xie G
[Ad] Endereço:Paul C Lauterbur Research Centre for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
[Ti] Título:Black-blood T2* mapping with delay alternating with nutation for tailored excitation.
[So] Source:Magn Reson Imaging;40:91-97, 2017 Jul.
[Is] ISSN:1873-5894
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To develop a black-blood T2* mapping method using a Delay Alternating with Nutation for Tailored Excitation (DANTE) preparation combined with a multi-echo gradient echo (GRE) readout (DANTE-GRE). MATERIALS AND METHODS: Simulations of the Bloch equation for DANTE-GRE were performed to optimize sequence parameters. After optimization, the sequence was applied to a phantom scan and to neck and lower extremity scans conducted on 12 volunteers at 3T using DANTE-GRE, Motion-Sensitized Driven Equilibrium (MSDE)-GRE, and multi-echo GRE. T2* values were measured using an offset model. Statistical analyses were conducted to compare the T2* values between the three sequences. RESULTS: Simulation results showed that blood suppression can be achieved with various DANTE parameter adjustments. T2* maps acquired by DANTE-GRE were consistent and comparable to those acquired with multi-echo GRE in phantom experiments. In the in vivo experiments, DANTE-GRE was more comparable to multi-echo GRE than MSDE-GRE regarding the measurement of muscle T2* values. CONCLUSION: Due to its high signal intensity retention and effective blood signal suppression, DANTE-GRE allows for robust and accurate T2* quantification, superior to that of MSDE-GRE, while overcoming blood flow artifacts associated with traditional multi-echo GRE.
[Mh] Termos MeSH primário: Artefatos
Sangue
[Mh] Termos MeSH secundário: Seres Humanos
Movimento (Física)
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


  7 / 33499 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27773596
[Au] Autor:Peter T; Ellenberger D; Kim AA; Boeras D; Messele T; Roberts T; Stevens W; Jani I; Abimiku A; Ford N; Katz Z; Nkengasong JN
[Ad] Endereço:Clinton Health Access Initiative, Boston, MA, USA.
[Ti] Título:Early antiretroviral therapy initiation: access and equity of viral load testing for HIV treatment monitoring.
[So] Source:Lancet Infect Dis;17(1):e26-e29, 2017 Jan.
[Is] ISSN:1474-4457
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Scaling up access to HIV viral load testing for individuals undergoing antiretroviral therapy in low-resource settings is a global health priority, as emphasised by research showing the benefits of suppressed viral load for the individual and the whole population. Historically, large-scale diagnostic test implementation has been slow and incomplete because of service delivery and other challenges. Building on lessons from the past, in this Personal View we propose a new framework to accelerate viral load scale-up and ensure equitable access to this essential test. The framework includes the following steps: (1) ensuring adequate financial investment in scaling up this test; (2) achieving pricing agreements and consolidating procurement to lower prices of the test; (3) strengthening functional tiered laboratory networks and systems to expand access to reliable, high-quality testing across countries; (4) strengthening national leadership, with prioritisation of laboratory services; and (5) demand creation and uptake of test results by clinicians, nurses, and patients, which will be vital in ensuring viral load tests are appropriately used to improve the quality of care. The use of dried blood spots to stabilise and ship samples from clinics to laboratories, and the use of point-of-care diagnostic tests, will also be important for ensuring access, especially in settings with reduced laboratory capacity. For countries that have just started to scale up viral load testing, lessons can be learnt from countries such as Botswana, Brazil, South Africa, and Thailand, which have already established viral load programmes. This framework might be useful for guiding the implementation of viral load with the aim of achieving the new global HIV 90-90-90 goals by 2020.
[Mh] Termos MeSH primário: Fármacos Anti-HIV/uso terapêutico
Terapia Antirretroviral de Alta Atividade/métodos
Monitoramento de Medicamentos
Infecções por HIV/tratamento farmacológico
Manejo de Espécimes/métodos
[Mh] Termos MeSH secundário: Sangue/virologia
Dessecação/métodos
Saúde Global
Infecções por HIV/prevenção & controle
Infecções por HIV/virologia
Política de Saúde
Seres Humanos
Ciência de Laboratório Médico/organização & administração
Sistemas Automatizados de Assistência Junto ao Leito/organização & administração
Carga Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-HIV Agents)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180124
[Lr] Data última revisão:
180124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  8 / 33499 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29267359
[Au] Autor:Zhang X; Azhar G; Wei JY
[Ad] Endereço:Donald W. Reynolds Institute on Aging, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America.
[Ti] Título:SIRT2 gene has a classic SRE element, is a downstream target of serum response factor and is likely activated during serum stimulation.
[So] Source:PLoS One;12(12):e0190011, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The sirtuin proteins are an evolutionarily conserved family of NAD+-dependent deacetylases that regulate various cellular functions. Among the seven sirtuins, SIRT2 is predominantly found in the cytoplasm, and is present in a wide range of tissues. Recent studies indicate that SIRT2 plays an important role in metabolic homeostasis. Several studies indicate that SIRT2 is upregulated under serum deprivation conditions. Since the serum response factor gene usually responds rapidly to serum deprivation and/or serum restoration following deprivation, we hypothesized that a common mechanism may serve to regulate both SIRT2 and SRF during serum stimulation. Using a bioinformatics approach, we searched the SRF binding motif in the SIRT2 gene, and found one classic CArG element (CCATAATAGG) in the SIRT2 gene promoter, which was bound to SRF in the electrophoretic mobility shift assay (EMSA). Serum deprivation induced SIRT2 expression, while SRF and the SRF binding protein, p49/STRAP, repressed SIRT2 gene expression. SIRT2 gene expression was also repressed by the Rho/SRF inhibitor, CCG-1423. These data demonstrate that the classic SRE element in the SIRT2 gene promoter region is functional and therefore, SIRT2 gene is a downstream target of the Rho/SRF signaling pathway. The increased expression of SRF that was observed in the aged heart may affect SIRT2 gene expression and contribute to altered metabolic status in senescence.
[Mh] Termos MeSH primário: Fator de Resposta Sérica/metabolismo
Sirtuína 2/genética
[Mh] Termos MeSH secundário: Animais
Sequência de Bases
Sangue
Linhagem Celular
Meios de Cultura
Homeostase
Seres Humanos
Regiões Promotoras Genéticas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Culture Media); 0 (Serum Response Factor); EC 3.5.1.- (SIRT2 protein, human); EC 3.5.1.- (Sirtuin 2)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190011


  9 / 33499 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28459220
[Au] Autor:Wu D; Zhou S; Hu S; Liu B
[Ad] Endereço:Nanjing First Hospital, Nanjing Medical University, Nanjing, China. wudan7451321@26.com.
[Ti] Título:Inflammatory responses and histopathological changes in a mouse model of Staphylococcus aureus-induced bloodstream infections.
[So] Source:J Infect Dev Ctries;11(4):294-305, 2017 Apr 30.
[Is] ISSN:1972-2680
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Staphylococcus aureus-induced bloodstream infections (BSIs) remain a prevalent clinical challenge and the underlying pathogenesis is still poorly understood. The aim of this study was to investigate the inflammatory responses and histopathological changes in BSIs in mice. METHODOLOGY: Male C57BL/6 mice were inoculated with S. aureus intravenously to induce BSIs. The survival rate, weight loss, and murine sepsis scores (MSS) were monitored in BSI and phosphate-buffered saline (PBS) control mice. Blood samples and tissue homogenates were plated on agar plates to determine the bacterial burden. Inflammatory proteins and cytokines were determined by enzyme-linked immunosorbent assay (ELISA) kits. Histopathologic changes were assessed by pathological inflammation score (PIS) and macroscopic and microscopic examinations. RESULTS: BSI mice induced by 4.5 × 108 CFU/mL S. aureus showed ~70% survival rate, higher sepsis scores, significantly decreased body weight, elevated levels of white blood cell (WBC) counts, C-reactive protein (CRP), procalcitonin (PCT), interleukin (IL)-1ß, IL-6, and tumor necrosis factor (TNF)-α. Prominent correlations were found between elevated CRP and PCT levels as well as among IL-1ß, IL-6, and TNF-α. Pathological changes and higher PIS were also observed in BSI mice. CONCLUSIONS: Our results demonstrate that inflammatory proteins (PCT and CRP) and cytokines (IL-6, IL-1ß and TNF-α) play an important role in the inflammatory responses and histopathological changes in S. aureus-induced BSIs.
[Mh] Termos MeSH primário: Bacteriemia/patologia
Inflamação/patologia
Infecções Estafilocócicas/patologia
[Mh] Termos MeSH secundário: Animais
Carga Bacteriana
Sangue/microbiologia
Peso Corporal
Proteína C-Reativa/análise
Calcitonina/sangue
Citocinas/sangue
Modelos Animais de Doenças
Ensaio de Imunoadsorção Enzimática
Histocitoquímica
Camundongos
Camundongos Endogâmicos C57BL
Índice de Gravidade de Doença
Análise de Sobrevida
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 9007-12-9 (Calcitonin); 9007-41-4 (C-Reactive Protein)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180109
[Lr] Data última revisão:
180109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.3855/jidc.7800


  10 / 33499 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29174782
[Au] Autor:St-Onge S; Perrault LP; Demers P; Boyle EM; Gillinov AM; Cox J; Melby S
[Ad] Endereço:Department of Cardiac Surgery, Montreal Heart Institute, Université de Montréal, Quebec, Canada.
[Ti] Título:Pericardial Blood as a Trigger for Postoperative Atrial Fibrillation After Cardiac Surgery.
[So] Source:Ann Thorac Surg;105(1):321-328, 2018 Jan.
[Is] ISSN:1552-6259
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Prevention strategies have long been sought to reduce the incidence and burden of postoperative atrial fibrillation (POAF) after heart surgery. However, none has emerged as a dominant and widely applicable prophylactic measure. The purpose of this review is to consider the biological mechanisms by which shed mediastinal blood leads to oxidation and inflammation within the postoperative pericardial environment and how this might trigger POAF in susceptible persons, as well as how it could represent a new target for prevention of POAF. METHODS: We conducted a structured research of literature using PubMed and MEDLINE databases to May 2016. Biomolecular and clinical articles focused on assessing the contribution of pericardial blood, or the resulting inflammation within the pericardial space and its potential role in triggering POAF, were included in this review. RESULTS: Evidence suggests that shed mediastinal blood through breakdown products, activation of coagulation cascade, and oxidative burst contributes to a highly pro-oxidant and proinflammatory milieu found within the pericardial space that can trigger postoperative atrial fibrillation in susceptible persons. The extent of this reaction could be blunted by reducing the exposition of pericardium to blood either through posterior pericardiotomy or improved chest drainage. CONCLUSIONS: Shed mediastinal blood undergoing transformation within the pericardium appears to be an important contributing factor to POAF. Strategies to prevent shed mediastinal blood from pooling around the heart might be considered in developing future paradigms for prevention of POAF.
[Mh] Termos MeSH primário: Fibrilação Atrial/etiologia
Sangue
Procedimentos Cirúrgicos Cardíacos
Pericárdio
Complicações Pós-Operatórias/etiologia
[Mh] Termos MeSH secundário: Fibrilação Atrial/prevenção & controle
Fenômenos Fisiológicos Sanguíneos
Seres Humanos
Mediastino
Complicações Pós-Operatórias/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171228
[Lr] Data última revisão:
171228
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE



página 1 de 3350 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde