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[PMID]:29405684
[Au] Autor:Leonovich SA; Filimonova SA
[Ti] Título:[The quill mite Syringophilopsis fringilla (Fritsch) (Acari: Trombidiformes: Syringophilidae): The structure of receptor organs providing feeding of the parasite inside the feather quill].
[So] Source:Parazitologiia;51(2):121-31, 2017 Mar-Apr.
[Is] ISSN:0031-1847
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The structure of sensory organs situated on palps and inside the cheliceral stylet of the quill mite Sringophilopsis fringilla (Fritsch, 1958) was examined in scanning and transmitting electron microscopes. Eight sensilla of 3 types were revealed on palptarsus, including two contact chemo-mechanosensory sensilla, a single distant chemosensory (probably olfactory) sensillum, and 5 tactile mechanosensitive sensilla. All other sensilla situated on basas parts of the palp and on the outer surface of gnathosoma are represented by tactile mechanoreceptors. A proprioceptor sensillum was revealed in the movable digit of the chelicera; modified cilia of dendrites of 5 sensory neurons run in the inner non-sclerotized core of the stylet, ending at different levels as electron-dense rods connected with the sclerotized wall of the stylet. The authors assume that the proprioceptor sensillum of the stylet detects the pressing force of the movable digit on the inner wall of the quill during piercing process, while papal sensilla determine the optimal place for piercing.
[Mh] Termos MeSH primário: Plumas/parasitologia
Mecanorreceptores/ultraestrutura
Ácaros/ultraestrutura
Passeriformes/parasitologia
Sensilas/ultraestrutura
[Mh] Termos MeSH secundário: Animais
Feminino
Linfa/parasitologia
Mecanorreceptores/fisiologia
Ácaros/fisiologia
Sensilas/fisiologia
Olfato/fisiologia
Percepção do Tato/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


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[PMID]:28456773
[Au] Autor:Beck B
[Ad] Endereço:Medical Centre of Science and Diagnostic BB-Med, Medical Laboratory, Opole, Poland. brygida.beck@bb-med.pl.
[Ti] Título:Transforming growth factor-ß1 and tumor necrosis factor-α concentration in serum during disturbed lymph flow from a liver in rats.
[So] Source:J Physiol Pharmacol;68(1):91-98, 2017 Feb.
[Is] ISSN:1899-1505
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:In the last decades an increasing attention has been devoted to the role of lymphatic system in pathomechanism. The disturbed lymph flow from a liver contributes to liver fibrogenesis and probably to hepatocirrhosis. Cytokines play a major role in the development of hepatic fibrosis, the wound-healing response of the liver to chronic injury. Cytokines in hepatic fibrogenesis may be pro- or antifibrogenic. Transforming growth factor-ß1 (TGF-ß1) is pro-fibrogenic cytokine and plays a key role in liver fibrogenesis. Interferon-γ (INF-γ) is anti-fibrogenic by downregulating hepatic stellate cell activation. We described the negative correlation between tumor necrosis factor-α (TNF-α) and IFN-γ concentration in serum during disturbed lymph flow from a liver of rats. TNF-α plays a antifibrogenic role in liver fibrogenesis too. Male Albino Wistar rats weighing 250 - 300 grams were selected for the experiment. The animals were kept in stable condition and were fed a standard diet with no fluid restriction. The rats were divided into 3 groups: group B - mechanical insufficiency was obtained by ligation of hepatic trunc, group K - underwent sham operation, group 0 - rats not subjected to any surgery. The animals were sacrificed for experiment in 1, 3, 7, 14, 21, 28, 35, 56 and 103 day after operation. During experiment TGF-ß1 and TNF-α concentration in serum were assayed. We observed a positive correlation between TGF-ß1 and TNF-α concentration in serum. During disturbed lymph flow from the liver TNF-α plays probably a antifibrogenic role in liver fibrogenesis.
[Mh] Termos MeSH primário: Cirrose Hepática/sangue
Fígado/metabolismo
Fator de Crescimento Transformador beta1/sangue
Fator de Necrose Tumoral alfa/sangue
[Mh] Termos MeSH secundário: Animais
Cirrose Hepática/metabolismo
Linfa/metabolismo
Masculino
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Transforming Growth Factor beta1); 0 (Tumor Necrosis Factor-alpha)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE


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[PMID]:29244910
[Au] Autor:Poveshchenko AF; Kazakov OV; Orlov NB; Poveshchenko OV; Kim II; Bondarenko NA; Solovieva IG; Strunkin DN; Kabakov AV; Rayter TV; Lykov AP; Bogachev SS; Pokushalov EA; Konenkov VI
[Ti] Título:Lymph cytokines as markers oncogenesis and effective treatment of experimental breast cancer Wistar rat.
[So] Source:Patol Fiziol Eksp Ter;60(3):68-75, 2016 Jul-Sep.
[Is] ISSN:0031-2991
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:The purpose of this paper is to examine the levels of cytokines in the lymph involved in the pathogenesis of breast cancer. Methods: Breast cancer was induced by introducing n-methyl-N-nitrosourea rats Wistar breed. Some of the animals subjected to surgery alone or chemotherapy alone (cyclophosphamide, methotrexate, 5-fluorouracil). Some animals combine both types of therapy, as well as a separate group to the administration of chemotherapy added Panagene drag presenting a fragmented DNA. To investigate the concentration of cytokines used in lymph test system Bio-Plex Pro Rat Cytokoness 24-Plex Assay (Bio-Rad, USA). Results: In rats with breast cancer content of most studied cytokines such as, IL-1b, IL-2, IL-4, IL-6, IL-7, IL-12, IL-13, IL-17A, MIP-1a, MIP-3a, RANTES, TNF-a, MCP-1 was significantly higher than in intact animals. Surgical removal of the tumor resulted in a significant decrease in the content in the lymph as a pro-inflammatory cytokine. Comparative performance study cytokine content in the lymph after tumor removal from intact animals showed that the content of cytokines such as IL-10, IL-18, GRO / KC, RANTES were significantly higher in the control animals group. Conducting chemotherapy has led to a significant decrease in the content of IL-1b, IL-4, IL-6, IL-7, IL-10, MIP-1a, MIP-3a, RANTES in rat breast cancer lymph. Comparative study of cytokine content in the lymph operated animals after the administration of chemotherapy and Panagene revealed that most of the content indicators cytokines such as IL-5, IL-6, IL-7, IL-10, IL-13, IL-17A, IL- 18, GRO / KC, IFNg, MIP-3a in the lymph was higher after administration of the drug Panagene. Conclusion: In a comparative study cytokine profile lymph Wistar rats found that cytokine content depended on the therapy in animals with induced breast cancer. Lymph cytokine levels may serve as a diagnostic criterion for tumor growth, as well as the predictor of the effectiveness of the therapy and the risk of metastasis of breast cancer.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/metabolismo
Citocinas/metabolismo
Linfa/metabolismo
Neoplasias Mamárias Experimentais/metabolismo
[Mh] Termos MeSH secundário: Animais
Feminino
Neoplasias Mamárias Experimentais/patologia
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (Cytokines)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE


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[PMID]:28935759
[Au] Autor:Karlsen TV; Reikvam T; Tofteberg A; Nikpey E; Skogstrand T; Wagner M; Tenstad O; Wiig H
[Ad] Endereço:From the Department of Biomedicine, University of Bergen, Norway (T.V.K., T.R., A.T., E.N., T.S., M.W., O.T., H.W.); and Departments of Medicine (E.N.) and Pathology (M.W.), Haukeland University Hospital, Bergen, Norway. tine.karlsen@uib.no helge.wiig@uib.no.
[Ti] Título:Lymphangiogenesis Facilitates Initial Lymph Formation and Enhances the Dendritic Cell Mobilizing Chemokine CCL21 Without Affecting Migration.
[So] Source:Arterioscler Thromb Vasc Biol;37(11):2128-2135, 2017 Nov.
[Is] ISSN:1524-4636
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Lymphatic vessels play an important role in body fluid, as well as immune system homeostasis. Although the role of malfunctioning or missing lymphatics has been studied extensively, less is known on the functional consequences of a chronically expanded lymphatic network or lymphangiogenesis. APPROACH AND RESULTS: To this end, we used K14-VEGF-C (keratin-14 vascular endothelial growth factor-C) transgenic mice overexpressing the vascular endothelial growth factor C in skin and investigated the responses to inflammatory and fluid volume challenges. We also recorded interstitial fluid pressure, a major determinant of lymph flow. Transgenic mice had a strongly enhanced lymph vessel area in skin. Acute inflammation induced by lipopolysaccharide and chronic inflammation by delayed-type hypersensitivity both resulted in increased interstitial fluid pressure and reduced lymph flow, both to the same extent in wild-type and transgenic mice. Hyperplastic lymphatic vessels, however, demonstrated enhanced transport capacity after local fluid overload not induced by inflammation. In this situation, interstitial fluid pressure was increased to a similar extent in the 2 strains, thus, suggesting that the enhanced lymph vessel area facilitated initial lymph formation. The increased lymph vessel area resulted in an enhanced production of the chemoattractant CCL21 that, however, did not result in augmented dendritic cell migration after induction of local skin inflammation by fluorescein isothiocyanate. CONCLUSIONS: An expanded lymphatic network is capable of enhanced chemoattractant production, and lymphangiogenesis will facilitate initial lymph formation favoring increased clearance of fluid in situations of augmented fluid filtration.
[Mh] Termos MeSH primário: Quimiocina CCL21/metabolismo
Quimiotaxia
Células Dendríticas/metabolismo
Dermatite Alérgica de Contato/metabolismo
Linfa/metabolismo
Linfangiogênese
Vasos Linfáticos/metabolismo
Linfedema/metabolismo
[Mh] Termos MeSH secundário: Animais
Dermatite Alérgica de Contato/genética
Dermatite Alérgica de Contato/patologia
Dermatite Alérgica de Contato/fisiopatologia
Modelos Animais de Doenças
Líquido Extracelular/metabolismo
Feminino
Deslocamentos de Líquidos Corporais
Fluoresceína-5-Isotiocianato
Genótipo
Queratina-14/genética
Lipopolissacarídeos
Vasos Linfáticos/patologia
Vasos Linfáticos/fisiopatologia
Linfedema/genética
Linfedema/patologia
Linfedema/fisiopatologia
Masculino
Camundongos Endogâmicos C3H
Camundongos Transgênicos
Oxazolona
Fenótipo
Pressão
Regiões Promotoras Genéticas
Transdução de Sinais
Fatores de Tempo
Regulação para Cima
Fator C de Crescimento do Endotélio Vascular/genética
Fator C de Crescimento do Endotélio Vascular/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chemokine CCL21); 0 (Keratin-14); 0 (Lipopolysaccharides); 0 (Vascular Endothelial Growth Factor C); 15646-46-5 (Oxazolone); I223NX31W9 (Fluorescein-5-isothiocyanate)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170923
[St] Status:MEDLINE
[do] DOI:10.1161/ATVBAHA.117.309883


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[PMID]:28367925
[Au] Autor:Fujii A; Manabe Y; Aida K; Tsuduki T; Hirata T; Sugawara T
[Ad] Endereço:Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University.
[Ti] Título:Selective Absorption of Dietary Sphingoid Bases from the Intestine via Efflux by P-Glycoprotein in Rats.
[So] Source:J Nutr Sci Vitaminol (Tokyo);63(1):44-50, 2017.
[Is] ISSN:1881-7742
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Various physiological functions of dietary sphingolipids, such as preventing inflammation and improving the skin barrier function, have been recently demonstrated. The sphingolipid most commonly used as a foodstuff is glucosylceramide from plant sources, which is composed of sphingoid bases that are distinctive from those found in mammals. Although the structure of sphingoid bases in higher plants is more complicated than the structure of those in mammals, the fate of dietary sphingolipids of plant origin is still not understood. In the present study, we investigated the absorption of 4,8-sphingadienine that originated from maize glucosylceramide in the rat intestine by using a lipid absorption assay of lymph collected from the thoracic duct. The cumulative recovery of 4,8-sphingadienine in the lymph was lower than that of sphingosine. Verapamil, a P-glycoprotein inhibitor, significantly increased the absorption of 4,8-sphingadienine but did not affect the absorption of sphingosine. Plant-derived sphingoid bases were detected in the ceramide fraction of lymph fluid by using liquid chromatography-mass spectrometry analysis. These results indicate that 4,8-sphingadienine that originates from the glucosylceramide of higher plants is poorly absorbed in the intestine because of efflux by P-glycoprotein and can be incorporated into a ceramide moiety, at least in part, in intestinal endothelial cells.
[Mh] Termos MeSH primário: Membro 1 da Subfamília B de Cassetes de Ligação de ATP/fisiologia
Etanolaminas/farmacocinética
Absorção Intestinal/fisiologia
Esfingolipídeos/farmacocinética
[Mh] Termos MeSH secundário: Membro 1 da Subfamília B de Cassetes de Ligação de ATP/antagonistas & inibidores
Animais
Etanolaminas/análise
Etanolaminas/metabolismo
Glucosilceramidas/química
Linfa/química
Masculino
Ratos
Ratos Sprague-Dawley
Esfingolipídeos/metabolismo
Esfingosina/análise
Verapamil/farmacologia
Zea mays/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ATP-Binding Cassette, Sub-Family B, Member 1); 0 (Ethanolamines); 0 (Glucosylceramides); 0 (Sphingolipids); 25696-03-1 (sphingadienine); CJ0O37KU29 (Verapamil); NGZ37HRE42 (Sphingosine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE
[do] DOI:10.3177/jnsv.63.44


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[PMID]:28363640
[Au] Autor:King A; Houlihan DD; Kavanagh D; Haldar D; Luu N; Owen A; Suresh S; Than NN; Reynolds G; Penny J; Sumption H; Ramachandran P; Henderson NC; Kalia N; Frampton J; Adams DH; Newsome PN
[Ad] Endereço:Birmingham Liver Biomedical Research Unit, National Institute for Health Research, Centre for Liver Research, University of Birmingham, Birmingham, United Kingdom. Electronic address: andyking@doctors.org.uk.
[Ti] Título:Sphingosine-1-Phosphate Prevents Egress of Hematopoietic Stem Cells From Liver to Reduce Fibrosis.
[So] Source:Gastroenterology;153(1):233-248.e16, 2017 Jul.
[Is] ISSN:1528-0012
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND & AIMS: There is growing interest in the use of bone marrow cells to treat liver fibrosis, however, little is known about their antifibrotic efficacy or the identity of their effector cell(s). Sphingosine-1-phosphate (S1P) mediates egress of immune cells from the lymphoid organs into the lymphatic vessels; we investigated its role in the response of hematopoietic stem cells (HSCs) to liver fibrosis in mice. METHODS: Purified (c-kit+/sca1+/lin-) HSCs were infused repeatedly into mice undergoing fibrotic liver injury. Chronic liver injury was induced in BoyJ mice by injection of carbon tetrachloride (CCl ) or placement on a methionine-choline-deficient diet. Some mice were irradiated and given transplants of bone marrow cells from C57BL6 mice, with or without the S1P antagonist FTY720; we then studied HSC mobilization and localization. Migration of HSC lines was quantified in Transwell assays. Levels of S1P in liver, bone marrow, and lymph fluid were measured using an enzyme-linked immunosorbent assay. Liver tissues were collected and analyzed by immunohistochemical quantitative polymerase chain reaction and sphingosine kinase activity assays. We performed quantitative polymerase chain reaction analyses of the expression of sphingosine kinase 1 and 2, sphingosine-1-phosphate lyase 1, and sphingosine-1-phosphate phosphatase 1 in normal human liver and cirrhotic liver from patients with alcohol-related liver disease (n = 6). RESULTS: Infusions of HSCs into mice with liver injury reduced liver scarring based on picrosirius red staining (49.7% reduction in mice given HSCs vs control mice; P < .001), and hepatic hydroxyproline content (328 mg/g in mice given HSCs vs 428 mg/g in control mice; P < .01). HSC infusion also reduced hepatic expression of α-smooth muscle actin (0.19 ± 0.007-fold compared with controls; P < .0001) and collagen type I α 1 chain (0.29 ± 0.17-fold compared with controls; P < .0001). These antifibrotic effects were maintained with infusion of lymphoid progenitors that lack myeloid potential and were associated with increased numbers of recipient neutrophils and macrophages in liver. In studies of HSC cell lines, we found HSCs to recruit monocytes, and this process to require C-C motif chemokine receptor 2. In fibrotic liver tissue from mice and patients, hepatic S1P levels increased owing to increased hepatic sphingosine kinase-1 expression, which contributed to a reduced liver:lymph S1P gradient and limited HSC egress from the liver. Mice given the S1P antagonist (FTY720) with HSCs had increased hepatic retention of HSCs (1697 ± 247 cells in mice given FTY720 vs 982 ± 110 cells in controls; P < .05), and further reductions in fibrosis. CONCLUSIONS: In studies of mice with chronic liver injury, we showed the antifibrotic effects of repeated infusions of purified HSCs. We found that HSCs promote recruitment of endogenous macrophages and neutrophils. Strategies to reduce SIP signaling and increase retention of HSCs in the liver could increase their antifibrotic activities and be developed for treatment of patients with liver fibrosis.
[Mh] Termos MeSH primário: Movimento Celular/efeitos dos fármacos
Transplante de Células-Tronco Hematopoéticas
Células-Tronco Hematopoéticas/fisiologia
Cirrose Hepática/prevenção & controle
Lisofosfolipídeos/antagonistas & inibidores
Lisofosfolipídeos/metabolismo
Esfingosina/análogos & derivados
[Mh] Termos MeSH secundário: Actinas/metabolismo
Aldeído Liases/genética
Animais
Linhagem Celular
Doença Hepática Crônica Induzida por Substâncias e Drogas/complicações
Colágeno Tipo I/metabolismo
Feminino
Cloridrato de Fingolimode/uso terapêutico
Expressão Gênica
Seres Humanos
Imunossupressores/uso terapêutico
Fígado/metabolismo
Fígado/patologia
Cirrose Hepática/etiologia
Cirrose Hepática/genética
Cirrose Hepática/patologia
Linfa/metabolismo
Macrófagos
Masculino
Proteínas de Membrana/genética
Camundongos
Monócitos
Neutrófilos
Monoéster Fosfórico Hidrolases/genética
Fosfotransferases (Aceptor do Grupo Álcool)/genética
Fosfotransferases (Aceptor do Grupo Álcool)/metabolismo
Esfingosina/antagonistas & inibidores
Esfingosina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Actins); 0 (Collagen Type I); 0 (Immunosuppressive Agents); 0 (Lysophospholipids); 0 (Membrane Proteins); 0 (alpha-smooth muscle actin, mouse); 0 (collagen type I, alpha 1 chain); 26993-30-6 (sphingosine 1-phosphate); EC 2.7.1.- (Phosphotransferases (Alcohol Group Acceptor)); EC 2.7.1.- (sphingosine kinase); EC 3.1.3.- (sphingosine-1-phosphate phosphatase); EC 3.1.3.2 (Phosphoric Monoester Hydrolases); EC 4.1.2.- (Aldehyde-Lyases); EC 4.1.2.27 (sphingosine 1-phosphate lyase (aldolase)); G926EC510T (Fingolimod Hydrochloride); NGZ37HRE42 (Sphingosine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170402
[St] Status:MEDLINE


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[PMID]:28327108
[Au] Autor:Gié O; Matthey-Gié ML; Marques-Vidal PM; Demartines N; Matter M
[Ad] Endereço:Department of Visceral Surgery, University Hospital of Lausanne, Rue du Bugnon 46, Lausanne, CHUV, 1011, Switzerland. olivier.gie@chuv.ch.
[Ti] Título:Impact of the Ultrasonic scalpel on the amount of drained lymph after axillary or inguinal lymphadenectomy.
[So] Source:BMC Surg;17(1):27, 2017 Mar 21.
[Is] ISSN:1471-2482
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Seroma formation and lymphoedema are frequently encountered complications after radical lymph node dissection (RLND). Attempts to reduce the lymphatic morbidity include the use of Ultrasonic Scalpel. The aim of the present analysis was to assess the impact of the ultrasonic scalpel on the amount of drained lymph after lymph node dissection. METHODS: Patients listed for a RLND or completion lymph node dissection (CLND) were enrolled in a prospective randomized trial to compare the impact of two surgical dissection techniques (USS versus control) on the amount of drained lymph. The lymph drained in 24 h was collected. Our primary endpoint was to compare the daily amount of drained lymph between the two groups. Secondary endpoints were the comparison of drained lymph with the BMI of the patients, the gender and the surgical site (axilla, groin). RESULTS: Eighty patients were randomly assigned to the USS group or the Control (C) group. No difference was measured in the total amount of lymph drained (USS: 2908 ± 2453 ml vs. C: 3898 ± 5791 ml; p-value = 0.382). The result was also similar after adjusting for gender, age, and BMI. A significant higher amount of lymph was measured after inguinal dissection with USS compared to axillary (p < 0.001). CONCLUSION: The study suggests that the use of Harmonic scalpel did not influence the amount of lymph drained after RLND and not support the theory that USS induces oversealing of lymphatics. TRIAL REGISTRATION: Clinical Trial NCT02476357 . Registered 20 of February 2015.
[Mh] Termos MeSH primário: Excisão de Linfonodo/efeitos adversos
Excisão de Linfonodo/instrumentação
Seroma/etiologia
Procedimentos Cirúrgicos Ultrassônicos/instrumentação
[Mh] Termos MeSH secundário: Adulto
Idoso
Axila
Drenagem
Feminino
Virilha
Seres Humanos
Linfa
Masculino
Meia-Idade
Estudos Prospectivos
Seroma/terapia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170502
[Lr] Data última revisão:
170502
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE
[do] DOI:10.1186/s12893-017-0222-1


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[PMID]:28259929
[Au] Autor:Sakamoto W; Masuno T; Yokota H; Takizawa T
[Ad] Endereço:Department of Molecular Medicine and Anatomy, Nippon Medical School, Tokyo 113­8602, Japan.
[Ti] Título:Expression profiles and circulation dynamics of rat mesenteric lymph microRNAs.
[So] Source:Mol Med Rep;15(4):1989-1996, 2017 Apr.
[Is] ISSN:1791-3004
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:Mesenteric lymph is vital for immune cell trafficking and intestinal fluid and chyle transport, which aid homeostatic maintenance. There have been few reports investigating the profiles and circulatory dynamics of mesenteric lymph microRNAs (miRNAs). The present study aimed to provide a comprehensive analysis of miRNAs in normal rodent mesenteric lymph. Reverse transcription­quantitative polymerase chain reaction (RT­qPCR)­based array analysis was performed to examine the expression levels of 375 miRNAs in normal rat mesenteric lymph. Using differential centrifugation, the presence of miR­150, a representative lymph miRNA, in exosomes was assessed. Rat small intestine epithelial cell line IEC­6­derived exosomes were prepared from culture supernatants of cells transfected with cel­miR­238­3p, and were used to trace the administered exosomes in vivo and to investigate the in vivo delivery of lymph miRNAs via mesenteric lymphatics into the systemic circulation following injection of cel­miR­238­3p­exosomes. RT­qPCR­based array analysis detected 287 miRNAs in lymph, and 21 miRNAs that were significantly differentially expressed between lymph and plasma. Lymph fractionation analysis demonstrated that some cell­free lymph miR­150 was distributed in the exosome­containing microsomal fraction. Furthermore, in vivo analysis of lymph miRNA delivery revealed that exosomal cel­miR­238­3p was markedly distributed in the lung compared with in the liver, kidney and spleen, thus indicating that the lung is the major organ responsible for clearance of exosomal lymph miRNAs. These findings provide novel insights into the modulation of gene expression by mesenteric lymph miRNAs in the lung.
[Mh] Termos MeSH primário: Exossomos/genética
Linfa/metabolismo
Mesentério/metabolismo
MicroRNAs/análise
MicroRNAs/genética
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Perfilação da Expressão Gênica
Masculino
Mesentério/irrigação sanguínea
MicroRNAs/administração & dosagem
Estabilidade de RNA
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MicroRNAs)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170516
[Lr] Data última revisão:
170516
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170306
[St] Status:MEDLINE
[do] DOI:10.3892/mmr.2017.6259


  9 / 6256 MEDLINE  
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[PMID]:28198188
[Au] Autor:Chung MY; Woo H; Kim J; Kong D; Choi HD; Choi IW; Kim IH; Noh SK; Kim BH
[Ad] Endereço:Korea Food Research Institute , Seongnam 13539, Korea.
[Ti] Título:Pinolenic Acid in Structured Triacylglycerols Exhibits Superior Intestinal Lymphatic Absorption As Compared to Pinolenic Acid in Natural Pine Nut Oil.
[So] Source:J Agric Food Chem;65(8):1543-1549, 2017 Mar 01.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The positional distribution pattern of fatty acids (FAs) in the triacylglycerols (TAGs) affects intestinal absorption of these FAs. The aim of this study was to compare lymphatic absorption of pinolenic acid (PLA) present in structured pinolenic TAG (SPT) where PLA was evenly distributed on the glycerol backbone, with absorption of pine nut oil (PNO) where PLA was predominantly positioned at the sn-3 position. SPT was prepared via the nonspecific lipase-catalyzed esterification of glycerol with free FA obtained from PNO. Lymphatic absorption of PLA from PNO and from SPT was compared in a rat model of lymphatic cannulation. Significantly (P < 0.05) greater amounts of PLA were detected in lymph collected for 8 h from an emulsion containing SPT (28.5 ± 0.7% dose) than from an emulsion containing PNO (26.2 ± 0.6% dose), thereby indicating that PLA present in SPT has a greater capacity for lymphatic absorption than PLA from PNO.
[Mh] Termos MeSH primário: Ácidos Linolênicos/química
Ácidos Linolênicos/metabolismo
Linfa/metabolismo
Pinus/metabolismo
Óleos Vegetais/metabolismo
Triglicerídeos/metabolismo
[Mh] Termos MeSH secundário: Animais
Esterificação
Absorção Intestinal
Linfa/química
Masculino
Estrutura Molecular
Nozes/química
Nozes/metabolismo
Pinus/química
Óleos Vegetais/química
Ratos
Ratos Sprague-Dawley
Triglicerídeos/química
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Linolenic Acids); 0 (Plant Oils); 0 (Triglycerides); 13237-97-3 (5,9,12-octadecatrienoic acid)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170530
[Lr] Data última revisão:
170530
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170216
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.6b05216


  10 / 6256 MEDLINE  
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[PMID]:28167686
[Au] Autor:Nikpey E; Karlsen TV; Rakova N; Titze JM; Tenstad O; Wiig H
[Ad] Endereço:From the Department of Biomedicine, University of Bergen, Norway (E.N., T.V.K., O.T., H.W.); Department of Medicine, Haukeland University Hospital, Bergen, Norway (E.N.); Experimental and Clinical Research Center, Charité Medical Facility and the Max-Delbrueck Center for Molecular Medicine, Berlin,
[Ti] Título:High-Salt Diet Causes Osmotic Gradients and Hyperosmolality in Skin Without Affecting Interstitial Fluid and Lymph.
[So] Source:Hypertension;69(4):660-668, 2017 Apr.
[Is] ISSN:1524-4563
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The common notion is that the body Na is maintained within narrow limits for fluid and blood pressure homeostasis. Several studies have, however, shown that considerable amounts of Na can be retained or removed from the body without commensurate water loss and that the skin can serve as a major salt reservoir. Our own data from rats have suggested that the skin is hypertonic compared with plasma on salt storage and that this also applies to skin interstitial fluid. Even small electrolyte gradients between plasma and interstitial fluid would represent strong edema-generating forces. Because the water accumulation has been shown to be modest, we decided to reexamine with alternative methods in rats whether interstitial fluid is hypertonic during salt accumulation induced by high-salt diet (8% NaCl and 1% saline to drink) or deoxycorticosterone pellet implantation. These treatments resulted both in increased systemic blood pressure, skin salt, and water accumulation and in skin hyperosmolality. Interstitial fluid isolated from implanted wicks and lymph draining the skin was, however, isosmotic, and Na concentration in fluid isolated by centrifugation and in lymph was not different from plasma. Interestingly, by eluting layers of the skin, we could show that there was an osmolality and urea gradient from epidermis to dermis. Collectively, our data suggest that fluid leaving the skin as lymph is isosmotic to plasma but also that the skin can differentially control its own electrolyte microenvironment by creating local gradients that may be functionally important.
[Mh] Termos MeSH primário: Pressão Sanguínea/fisiologia
Líquido Extracelular/metabolismo
Hipertensão/metabolismo
Linfa/metabolismo
Pele/metabolismo
Cloreto de Sódio na Dieta/efeitos adversos
Desequilíbrio Hidroeletrolítico/metabolismo
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Hipertensão/etiologia
Hipertensão/fisiopatologia
Masculino
Ratos
Ratos Sprague-Dawley
Pele/efeitos dos fármacos
Equilíbrio Hidroeletrolítico
Desequilíbrio Hidroeletrolítico/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sodium Chloride, Dietary)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170208
[St] Status:MEDLINE
[do] DOI:10.1161/HYPERTENSIONAHA.116.08539



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