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[PMID]:28463420
[Au] Autor:Chang YC; Cole TB; Costa LG
[Ad] Endereço:Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington.
[Ti] Título:Behavioral Phenotyping for Autism Spectrum Disorders in Mice.
[So] Source:Curr Protoc Toxicol;72:11.22.1-11.22.21, 2017 May 02.
[Is] ISSN:1934-9262
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Autism spectrum disorder (ASD) represents a heterogeneous group of disorders characterized by alterations in three behavioral symptom domains: Social interactions, verbal and nonverbal communication, and repetitive behaviors. Increasing prevalence of ASD in recent years suggests that exposure to environmental toxicants may be critical in modulating etiology of this disease. As clinical diagnosis of autism still relies on behavioral evaluation, it is important to be able to assess similar behavioral traits in animal models, to provide biological plausibility of associations between environmental exposures and ASD. Rodents naturally exhibit a large number of behaviors that can be linked to similar behaviors in human. In this unit, behavioral tests are described that are relevant to the domains affected in ASD. For the repetitive domain, the T-maze spontaneous alternation test and marble burying test are described. For the communication domain, neonatal ultrasonic vocalization and olfactory habituation test toward social and non-social odor are described. Finally, for the sociability domain, the three-chambered social preference test and the reciprocal interaction test are presented. © 2017 by John Wiley & Sons, Inc.
[Mh] Termos MeSH primário: Transtorno do Espectro Autista/psicologia
Comportamento Animal
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Modelos Animais de Doenças
Habituação Psicofisiológica
Camundongos
Transtorno Obsessivo-Compulsivo/psicologia
Odorantes
Fenótipo
Olfato
Comportamento Social
Urina/química
Vocalização Animal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1002/cptx.19


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[PMID]:29231657
[Au] Autor:Myren-Svelstad S; Halgunset J
[Ti] Título:Urin har vært brukt til så mangt..
[So] Source:Tidsskr Nor Laegeforen;137(23-24), 2017 12 12.
[Is] ISSN:0807-7096
[Cp] País de publicação:Norway
[La] Idioma:nor
[Mh] Termos MeSH primário: Urina
[Mh] Termos MeSH secundário: Administração Oral
Administração Tópica
História do Século XVIII
História do Século XIX
História do Século XX
Seres Humanos
Mitologia
Urinálise/história
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.4045/tidsskr.17.0323


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[PMID]:28282741
[Au] Autor:Irwin C; Campagnolo N; Iudakhina E; Cox GR; Desbrow B
[Ad] Endereço:a Menzies Health Institute Queensland, School of Allied Health Sciences , Griffith University , Gold Coast , Queensland , Australia.
[Ti] Título:Effects of acute exercise, dehydration and rehydration on cognitive function in well-trained athletes.
[So] Source:J Sports Sci;36(3):247-255, 2018 Feb.
[Is] ISSN:1466-447X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study investigated the effects of aerobic exercise, fluid loss and rehydration on cognitive performance in well-trained athletes. Ten endurance-trained males (25 ± 5 years; 175 ± 5 cm; 70.35 ± 5.46 kg; VO , 62.95 ± 7.20 ml · kg.min ) lost ~2.5 ± 0.6% body mass via continuous cycling exercise at ~65% peak sustainable power output (60 min duration) before consuming different beverages (Water = W1 and W2, Sustagen Sport = SS, Powerade = PD) and food ad libitum on four separate occasions. Cognitive function using a four-choice reaction time task (CRT), body mass, fluid consumption volumes, urine samples and subjective ratings (alertness, concentration, energy) were obtained before and after exercise, and hourly during recovery (for 4 h). CRT latency was significantly reduced immediately after exercise compared to pre-exercise measures for all trials (W1 = -16 ± 18 ms, W2 = -22 ± 21 ms, PD = -22 ± 22 ms, SS = -19 ± 26 ms). However, this effect was short-lived with subsequent measures not different from pre-exercise values. No difference in CRT accuracy was observed at any time across all trials. Subjective ratings were not different at any time across all trials. Aerobic exercise, hypohydration or an interaction between these two may provide a small cognitive performance benefit. However, these effects are temporary and confined to the immediate post-exercise period.
[Mh] Termos MeSH primário: Cognição
Desidratação/terapia
Exercício/fisiologia
Exercício/psicologia
Hidratação
[Mh] Termos MeSH secundário: Adulto
Índice de Massa Corporal
Desidratação/fisiopatologia
Ingestão de Energia
Seres Humanos
Masculino
Tempo de Reação
Urina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170312
[St] Status:MEDLINE
[do] DOI:10.1080/02640414.2017.1298828


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[PMID]:29341567
[Au] Autor:Dordevic Z; Folic M; Jankovic S
[Ti] Título:Community-acquired urinary tract infections: Causative agents and their resistance to antimicrobial drugs.
[So] Source:Vojnosanit Pregl;73(12):1109-15, 2016 Dec.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Background/Aim: Urinary tract infections (UTIs) are among the most common infections in outpatients. The aim of this study was to define the causative agents of urinary tract infections and their resistance to antimicrobial drugs in the urban area of central Serbia, as well as to evaluate eventual differences associated with age and gender of the patients. Methods: This retrospective study analysed data taken from routine, consecutively collected urine cultures of outpatients with symptomatic UTIs, collected from the Department of Microbiology, Institute of Public Health in Kragujevac, Serbia, from January 2009 to December 2013. Results: There were 71,905 urine cultures, and 24,713 (34.37%) of them were positive for bacterial pathogens. The most common pathogen was Escherichia coli (E. coli) (56.56%), followed by Klebsiella spp. (16.20%), Proteus spp. (14.68%), Enterococcus spp. (5.29%) and Pseudomonas aeruginosa (3.74%). E. coli and Enterococcus spp. isolation rates were lower in males ≥ 60 years old (23.71% and 4.87%, respectively), while Klebsiella spp. was more prevalent in this group (32.06%). The most common causative agents isolated from 15­29 years old male patients were Enterococcus spp. and Pseudomonas aeruginosa (13.28% each). Among women, the isolation rate of E.coli was high in all age groups (around 70%). Proteus spp. was frequently isolated from females ≤ 14 years old (13.27%), while Klebsiella spp. was the most frequent in the oldest age female group (10.99%). Conclusion: Choice of antibiotics for treatment of UTIs should be governed not only by the local resistance patterns, but also by gender and age of patients.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Bactérias/efeitos dos fármacos
Infecções Comunitárias Adquiridas/tratamento farmacológico
Infecções Comunitárias Adquiridas/microbiologia
Farmacorresistência Bacteriana
Infecções Urinárias/tratamento farmacológico
Infecções Urinárias/microbiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Fatores Etários
Idoso
Idoso de 80 Anos ou mais
Bactérias/isolamento & purificação
Criança
Pré-Escolar
Tomada de Decisão Clínica
Infecções Comunitárias Adquiridas/diagnóstico
Infecções Comunitárias Adquiridas/epidemiologia
Feminino
Seres Humanos
Lactente
Masculino
Testes de Sensibilidade Microbiana
Meia-Idade
Seleção de Pacientes
Estudos Retrospectivos
Sérvia/epidemiologia
Fatores Sexuais
Infecções Urinárias/diagnóstico
Infecções Urinárias/epidemiologia
Urina/microbiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.2298/VSP150122218D


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[PMID]:28985844
[Au] Autor:Abahuje E; Munyaneza R; Riviello R; Ntirenganya F
[Ad] Endereço:Department of Surgery, Kigali University Teaching Hospital, Kigali, Rwanda. Electronic address: abegid@gmail.com.
[Ti] Título:Assessment of hemodynamic response to fluid resuscitation of patients with intra-abdominal sepsis in low- and middle-income countries.
[So] Source:J Surg Res;218:162-166, 2017 Oct.
[Is] ISSN:1095-8673
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Patients with intra-abdominal infections need to achieve adequate hemodynamic status before being taken to the operating room. Multiple parameters (urinary output [UOP], vital signs, inferior vena cava collapsibility index, and central venous pressure) may be used to assess hemodynamic response to fluid resuscitation, but the options are few in limited-resource settings. This study aimed at assessing if a bedside-performed ultrasound to assess the inferior vena cava collapsibility index is superior to UOP in assessing hemodynamic response to fluid resuscitation. METHODS: All adult patients presenting to a tertiary referral hospital in the capital city of Rwanda with intra-abdominal infection requiring intravenous fluid (IVF) resuscitation before operation were included in this study. Before IVF administration, the baseline inferior vena cava collapsibility index (IVC-CI) and vital parameters were recorded. After initiation of IVF resuscitation, serial measurements of IVC-CI and UOP were recorded every 2 h until the decision was made to take the patient to the operating room. RESULTS: Twenty-four patients were enrolled. The mean duration of symptoms was 4.7 days. Four patients (16%) had altered mental status as a presenting symptom. Half of all patients had generalized peritonitis due to gangrenous bowel as the primary diagnosis (n = 12). The mean difference between time of hemodynamic response based on IVC-CI versus UOP was 2 h (P < 0.001). CONCLUSIONS: Measurement of the IVC-CI can provide early detection of hemodynamic response to fluid therapy in patients with intra-abdominal infection with spontaneous breathing compared to UOP. Future research should utilize this parameter in the preoperative management of hemodynamically unstable patients.
[Mh] Termos MeSH primário: Hidratação
Infecções Intra-Abdominais/terapia
Ressuscitação
Sepse/terapia
Veia Cava Inferior/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Hemodinâmica
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Urina
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171008
[St] Status:MEDLINE


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[PMID]:28906365
[Au] Autor:Pouladfar G; Basiratnia M; Anvarinejad M; Abbasi P; Amirmoezi F; Zare S
[Ad] Endereço:aAlborzi Clinical Microbiology Research Center, Nemazee Teaching Hospital bDivision of Pediatric Nephrology cHematology Research Center dStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
[Ti] Título:The antibiotic susceptibility patterns of uropathogens among children with urinary tract infection in Shiraz.
[So] Source:Medicine (Baltimore);96(37):e7834, 2017 Sep.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Urinary tract infection (UTI) is one of the most common bacterial infections in pediatrics. Delay in diagnosis and treatment can cause significant morbidity. The physicians knowledge regarding the symptoms, microorganisms that caused UTI, and effective antibiotics in a geographical area can help them to select the appropriate antibiotics. This study was performed to determine the prevalence of bacteria that cause UTI and their susceptibility to common antibiotics as well as the common symptoms and associated factors in children of Shiraz, Southern Iran.This cross sectional study was performed among 202 children with UTI, aged 2 months to 18 years old, between August and November 2014 in pediatric medical centers of Shiraz University of Medical Sciences. Urine samples were collected using urinary catheter or suprapubic in children < 2 years and mid-stream in children over 2 years, respectively. The type of micro-organisms causing UTI was determined and evaluation of antibiotic susceptibility for each organism was assayed by the Kirby Bauer method using antibiogram test. Patient's information was collected through checking the medical documents and interview with parents.Our results showed that the frequency of UTI was significantly higher in girls (70.3%) than in boys. The most commonly discovered pathogens were Escherichia coli (E coli) (51.5%), followed by Klebsiella spp. (16.8%), and Enterococcus spp. (9.9%). Overall susceptibility test showed the highest resistance to ampicillin (81.2%) and cotrimoxazole (79.2%), and the highest sensitivity to imipenem (90.1%) and Gentamicin (65.3%). Gram negative and positive bacteria showed the highest antibiotic resistance to amoxicillin (83.8%) and clindamycin (100%), respectively. In addition, production of extended spectrum beta lactamase (ESBL) was 69.2% and 30.8% in E coli and Kelebsiella respectively.The efficacy of third generation of the cephalosporins was reduced because of the high rate of production of ESBL and drug resistance. These results inform the physician as to which antibiotics are appropriate to prescribe for the patient, as well as urine culture reports and following the patient's clinical response so that high antimicrobial resistance is not developed at the community level.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Resistência Microbiana a Medicamentos
Infecções Urinárias/tratamento farmacológico
Infecções Urinárias/microbiologia
Urina/microbiologia
[Mh] Termos MeSH secundário: Adolescente
Cateteres
Criança
Pré-Escolar
Estudos Transversais
Escherichia coli
Infecções por Escherichia coli/tratamento farmacológico
Infecções por Escherichia coli/epidemiologia
Feminino
Hospitais Pediátricos
Seres Humanos
Lactente
Irã (Geográfico)/epidemiologia
Masculino
Testes de Sensibilidade Microbiana
Prevalência
Estudos Prospectivos
Infecções Urinárias/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170915
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007834


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[PMID]:28877114
[Au] Autor:Bliss DZ; Bland P; Wiltzen K; Gannon A; Wilhems A; Mathiason MA; Turnbaugh R
[Ad] Endereço:Donna Z. Bliss, PhD, RN, FAAN, FGSA, University of Minnesota School of Nursing, Minneapolis. Peggy Bland, HSD, RN, Presbyterian Manor of Mid-America Nursing Home, Farmington, Missouri. Kjerstie Wiltzen, BA, BSN, RN, CWCN, University of Minnesota School of Nursing, Minneapolis. Alexandra Gannon, BSN, RN, University of Minnesota School of Nursing, Minneapolis. Anna Wilhems, BSN, RN, University of Minnesota School of Nursing, Minneapolis. Michelle A. Mathiason, MS, University of Minnesota School of Nursing, Minneapolis. Robert Turnbaugh, RN, Presbyterian Manor of Mid-America Nursing Home, Farmington, Missouri.
[Ti] Título:Incontinence Briefs Containing Spiral-Shaped Fiber Acidify Skin pH of Older Nursing Home Residents at Risk for Incontinence-Associated Dermatitis.
[So] Source:J Wound Ostomy Continence Nurs;44(5):475-480, 2017 Sep/Oct.
[Is] ISSN:1528-3976
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The study's purpose was to assess the pH of the skin of older (aged ≥75 years) incontinent nursing home residents after exposure to an incontinence brief containing spiral-shaped fiber wet with an alkaline solution mimicking urine or fecal pH and compared to skin pH after exposure to an industry standard brief wet with the same solution and various controls. DESIGN: The design was experimental, as conditions were applied to skin and skin pH was measured in random order, and subjects served as their own controls. SETTING AND SUBJECTS: The setting was a Midwestern nonprofit nursing home. The sample was 26 nursing home residents; their mean age was 87 years (SD = 6 years); 77% were female. Most (69%) had urinary incontinence alone, and 31% had dual urinary and fecal incontinence. METHODS: Skin pH was measured in duplicate on 6 areas of the inner thighs and 6 areas of the volar surface of the forearms. Each area was exposed to 1 of 6 conditions applied in random order: an incontinence brief containing spiral-shaped fiber wet with an alkaline solution and one that was dry; a standard incontinence brief (without spiral-shaped fiber) wet with the same alkaline solution and one that was dry; the alkaline solution alone; and normal skin. RESULTS: On both the thighs and the forearms, skin pH was significantly lower (more acidic) after exposure to the incontinence brief containing spiral-shaped fiber wet with an alkaline solution compared to the wet standard brief and all other control conditions (P < .001). On thighs, the mean skin pH was 5.7 (SD = 0.5) after exposure to the wet brief with spiral-shaped fiber versus 6.4 (SD = 0.5) after exposure to the wet standard brief. On forearms, the mean skin pH was 5.3 (SD = 0.4) after exposure to the wet brief with spiral-shaped fiber versus 6.0 (SD = 0.4) after exposure to the wet standard brief. CONCLUSIONS: Incontinence briefs containing a spiral-shaped fiber significantly acidify the pH of the skin exposed to an alkaline solution, while industry standard briefs do not. Since alkaline skin pH is a risk factor for incontinence-associated dermatitis (IAD), results suggest that briefs with spiral-shaped fiber may help prevent IAD. Findings encourage further research.
[Mh] Termos MeSH primário: Dermatite/etiologia
Concentração de Íons de Hidrogênio
Tampões Absorventes para a Incontinência Urinária/classificação
Tampões Absorventes para a Incontinência Urinária/normas
Urina/química
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Tampões Absorventes para a Incontinência Urinária/estatística & dados numéricos
Masculino
Meio-Oeste dos Estados Unidos
Casas de Saúde/organização & administração
Casas de Saúde/estatística & dados numéricos
Fatores de Risco
Higiene da Pele/enfermagem
Incontinência Urinária/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE
[do] DOI:10.1097/WON.0000000000000362


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[PMID]:28870946
[Au] Autor:Hamaguchi R; Okamoto T; Sato M; Hasegawa M; Wada H
[Ad] Endereço:Karasuma Wada Clinic, Yasaka Karasuma-oike Building 2F, Kyoto, Japan reo-h@nifty.com.
[Ti] Título:Effects of an Alkaline Diet on EGFR-TKI Therapy in EGFR Mutation-positive NSCLC.
[So] Source:Anticancer Res;37(9):5141-5145, 2017 09.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The acidic tumor microenvironment is associated with progression of cancers. The purpose of this study was to investigate the association between an alkaline diet and the effect of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) in non-small cell lung cancer (NSCLC) patients. PATIENTS AND METHODS: Eleven advanced or recurrent NSCLC patients with EGFR mutations treated with EGFR-TKI after being instructed to follow an alkaline diet were retrospectively evaluated. RESULTS: The median progression-free survival (PFS) and overall survival (OS) were 19.5 (range=3.1-33.8) and 28.5 (range=15.4-46.6) months. The average dosage of EGFR-TKI was 56±22% of the standard dosage. Urine pH was significantly increased after the alkaline diet (6.00±0.38 vs. 6.95±0.55; p<0.05). CONCLUSION: An alkaline diet may enhance the effect of EGFR-TKI treatment in NSCLC patients with EGFR mutations.
[Mh] Termos MeSH primário: Adenocarcinoma
Antineoplásicos/uso terapêutico
Carcinoma Pulmonar de Células não Pequenas
Neoplasias Pulmonares
Inibidores de Proteínas Quinases/uso terapêutico
Receptor do Fator de Crescimento Epidérmico/antagonistas & inibidores
[Mh] Termos MeSH secundário: Adenocarcinoma/diagnóstico por imagem
Adenocarcinoma/dietoterapia
Adenocarcinoma/tratamento farmacológico
Idoso
Carcinoma Pulmonar de Células não Pequenas/diagnóstico por imagem
Carcinoma Pulmonar de Células não Pequenas/dietoterapia
Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico
Carcinoma Pulmonar de Células não Pequenas/genética
Intervalo Livre de Doença
Cloridrato de Erlotinib/uso terapêutico
Feminino
Seres Humanos
Concentração de Íons de Hidrogênio
Estimativa de Kaplan-Meier
Neoplasias Pulmonares/diagnóstico por imagem
Neoplasias Pulmonares/dietoterapia
Neoplasias Pulmonares/tratamento farmacológico
Neoplasias Pulmonares/genética
Masculino
Meia-Idade
Mutação
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons
Quinazolinas/uso terapêutico
Receptor do Fator de Crescimento Epidérmico/genética
Urina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Protein Kinase Inhibitors); 0 (Quinazolines); 41UD74L59M (afatinib); DA87705X9K (Erlotinib Hydrochloride); EC 2.7.10.1 (Receptor, Epidermal Growth Factor); S65743JHBS (gefitinib)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170906
[St] Status:MEDLINE


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[PMID]:28845946
[Au] Autor:Yarovoi SK; Golovanov SA; Khaziakhmetova MR; Dzhalilov OV
[Ad] Endereço:N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology branch of the NMRRC of Minzdrav of Russia, Moscow, Russia.
[Ti] Título:[Nephrolithiasis coexisting with type 2 diabetes: current concept of the features of stone formation and the effects of hypoglycemic therapy on lithogenesis].
[So] Source:Urologiia;(3):92-97, 2017 Jul.
[Is] ISSN:1728-2985
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The article analyzes Russian and international literature examining specific features of the pathogenesis of renal stones in the setting of carbohydrate metabolism disorders. The authors outline the renal effects of the main pharmacological groups of oral hypoglycemic drugs regarding metaphylaxis of nephrolithiasis. An increased risk of nephrolithiasis in type 2 diabetes mellitus is realized through hyperuricemia with concurrent urine acidification. Current literature is lacking studies on the effects of oral hypoglycemic drugs on urine properties. There are reports about the tendency of biguanides (metformin) to shift the urine reaction to the acid side. Derivatives of sulfonylureas, incretins and inhibitors of dipeptidyl peptidase-4, do not significantly affect the urinary acidity and urinary salt excretion. Inhibitors of sodium-glucose cotransporter type 2 (gliflozins) tend to reduce the blood level of urate, but the mechanism of this effect and the safety of these drugs in the setting of urolithiasis have not yet been investigated.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/complicações
Diabetes Mellitus Tipo 2/tratamento farmacológico
Hipoglicemiantes/uso terapêutico
Nefrolitíase/tratamento farmacológico
Nefrolitíase/etiologia
[Mh] Termos MeSH secundário: Administração Oral
Diurese/efeitos dos fármacos
Intolerância à Glucose/complicações
Seres Humanos
Concentração de Íons de Hidrogênio
Hiperuricemia/complicações
Hipoglicemiantes/administração & dosagem
Hipoglicemiantes/farmacologia
Urina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Hypoglycemic Agents)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170829
[St] Status:MEDLINE


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Fotocópia
[PMID]:28845933
[Au] Autor:Kogan MI; Naboka YL; Bedzhanyan SK; Mitusova EV; Gudima IA; Morgun PP; Vasileva LI
[Ad] Endereço:RostSMU of Minzdrav of Russia, Rostov on Don, Russia.
[Ti] Título:[Is bacteriological testing of bladder urine informative in acute obstructive pyelo- nephritis?]
[So] Source:Urologiia;(3):10-15, 2017 Jul.
[Is] ISSN:1728-2985
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The problem of the etiology and pathogenesis of acute obstructive pyelonephritis (OOP) remains one of the challenging issues of modern urology. Etiological agents of pyelonephritis can be both gram-negative and gram-positive opportunistic bacteria mostly belonging to the normal flora in humans. The generally accepted diagnostic work-up involves a bacteriological testing of not pelvic urine, but of bladder urine collected by a transurethral catheter or midstream specimens of urine collected from the patients. The aim of our study was to compare the microbiota of bladder and pelvic urine in patients with OOP. MATERIALS AND METHODS: The study comprised 72 sequentially selected patients (12 men and 60 women) with OOP associated with ureteral stones. Mean age of patients was 53.7+/-0.5 years. All patients underwent bacteriological examination of the bladder urine collected by a transurethral catheter and pelvic urine obtained after relieving stone-related ureteral obstruction. Urinary diversion was performed using j-j stent and PCN in 64 and 8 patients, respectively. Preoperative prophylactic antibiotics were administered routinely. Bacteriological testing of urine was carried out using an extended set (9-10) of culture media. Empirical antibiotic therapy was initiated only after the restoration of urine outflow from the kidney and continued for 5-6 days until the availability of bacteriological testing results. RESULTS: Levels of bacteriuria with Enterobacteria, gram-positive pathogens and NAB in two urine samples did not differ significantly (p>0.05). There was a wide range of bacteriuria from 101 to 106 CFU/ml of most microorganisms except @Proteus spp., S. aureus. In bladder urine, the rates of bacteriuria of more or equal 104 CFU/ml for E. coli, Klebsiella spp. and Proteus spp. were 90.9%, 72.7% and 100.0%, respectively. For the remaining microorganisms, predominant bacteriuria was less or equal 103 CFU/ml. In pelvic urine, the rates of bacteriuria of more or equal 104 CFU/ml for E. coli, Klebsiella spp. and Proteus spp. was 71.8%, 40.0% and 66.7%, respectively. Other uropathogens in the pelvic urine mainly had a bacterial count of less or equal 103 CFU/ml. Only the concentration of Corynebacterium spp. in the pelvic urine significantly (p=0.023) differed from that of the bladder urine. There were no significant differences between microbiota of bladder and pelvic urine depending on duration of OOP except higher rates of Corynebacterium spp. in the bladder urine.
[Mh] Termos MeSH primário: Pielonefrite/urina
Infecções Urinárias/urina
Urina/microbiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Antibacterianos/administração & dosagem
Bacteriúria/prevenção & controle
Bacteriúria/urina
Corynebacterium/isolamento & purificação
Escherichia coli/isolamento & purificação
Feminino
Seres Humanos
Klebsiella/isolamento & purificação
Masculino
Meia-Idade
Proteus/isolamento & purificação
Pielonefrite/prevenção & controle
Infecções Urinárias/prevenção & controle
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170829
[St] Status:MEDLINE



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