Base de dados : MEDLINE
Pesquisa : A12.383.200 [Categoria DeCS]
Referências encontradas : 464 [refinar]
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[PMID]:28859336
[Au] Autor:Donson AM; Apps J; Griesinger AM; Amani V; Witt DA; Anderson RCE; Niazi TN; Grant G; Souweidane M; Johnston JM; Jackson EM; Kleinschmidt-DeMasters BK; Handler MH; Tan AC; Gore L; Virasami A; Gonzalez-Meljem JM; Jacques TS; Martinez-Barbera JP; Foreman NK; Hankinson TC; Advancing Treatment for Pediatric Craniopharyngioma Consortium
[Ad] Endereço:Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado; Developmental Biology and Cancer Programme, Great Ormond Street UCL Institute of Child Health, London, UK; Department of Neurological Surgery, Columbia University Medical Center, New York, New York; Division
[Ti] Título:Molecular Analyses Reveal Inflammatory Mediators in the Solid Component and Cyst Fluid of Human Adamantinomatous Craniopharyngioma.
[So] Source:J Neuropathol Exp Neurol;76(9):779-788, 2017 Sep 01.
[Is] ISSN:1554-6578
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Pediatric adamantinomatous craniopharyngioma (ACP) is a highly solid and cystic tumor, often causing substantial damage to critical neuroendocrine structures such as the hypothalamus, pituitary gland, and optic apparatus. Paracrine signaling mechanisms driving tumor behavior have been hypothesized, with IL-6R overexpression identified as a potential therapeutic target. To identify potential novel therapies, we characterized inflammatory and immunomodulatory factors in ACP cyst fluid and solid tumor components. Cytometric bead analysis revealed a highly pro-inflammatory cytokine pattern in fluid from ACP compared to fluids from another cystic pediatric brain tumor, pilocytic astrocytoma. Cytokines and chemokines with particularly elevated concentrations in ACPs were IL-6, CXCL1 (GRO), CXCL8 (IL-8) and the immunosuppressive cytokine IL-10. These data were concordant with solid tumor compartment transcriptomic data from a larger cohort of ACPs, other pediatric brain tumors and normal brain. The majority of receptors for these cytokines and chemokines were also over-expressed in ACPs. In addition to IL-10, the established immunosuppressive factor IDO-1 was overexpressed by ACPs at the mRNA and protein levels. These data indicate that ACP cyst fluids and solid tumor components are characterized by an inflammatory cytokine and chemokine expression pattern. Further study regarding selective cytokine blockade may inform novel therapeutic interventions.
[Mh] Termos MeSH primário: Craniofaringioma/metabolismo
Líquido Cístico/metabolismo
Citocinas/metabolismo
Neoplasias Hipofisárias/metabolismo
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Estudos de Coortes
Craniofaringioma/genética
Craniofaringioma/patologia
Líquido Cístico/imunologia
Feminino
Perfilação da Expressão Gênica
Regulação Neoplásica da Expressão Gênica/fisiologia
Seres Humanos
Indolamina-Pirrol 2,3,-Dioxigenase/genética
Indolamina-Pirrol 2,3,-Dioxigenase/metabolismo
Masculino
Análise em Microsséries
Neoplasias Hipofisárias/genética
Neoplasias Hipofisárias/patologia
RNA Mensageiro/metabolismo
Receptores de Interleucina-6/genética
Receptores de Interleucina-6/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Cytokines); 0 (Indoleamine-Pyrrole 2,3,-Dioxygenase); 0 (RNA, Messenger); 0 (Receptors, Interleukin-6); 0 (indoleamine 2,3-dioxygenase 1, human)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170902
[St] Status:MEDLINE
[do] DOI:10.1093/jnen/nlx061


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[PMID]:28739154
[Au] Autor:Yip-Schneider MT; Carr RA; Wu H; Schmidt CM
[Ad] Endereço:Department of Surgery, Indiana University School of Medicine, Indianapolis, IN; Walther Oncology Center, Indianapolis, IN; Indiana University Cancer Center, Indianapolis, IN; Indiana University Pancreatic Cyst and Cancer Early Detection Center, Indianapolis, IN.
[Ti] Título:Prostaglandin E : A Pancreatic Fluid Biomarker of Intraductal Papillary Mucinous Neoplasm Dysplasia.
[So] Source:J Am Coll Surg;225(4):481-487, 2017 Oct.
[Is] ISSN:1879-1190
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: With the increased frequency of diagnostic imaging, pancreatic cysts are now detected in >3% of American adults. Most of these are intraductal papillary mucinous neoplasms (IPMNs) with well-established but variable malignant potential. A biomarker that predicts malignant potential or dysplastic grade would help determine which IPMNs require removal and which can be observed safely. We previously reported that pancreatic fluid prostaglandin E (PGE ) levels might have promise as a predictor of IPMN dysplasia and we seek to validate those results in the current study. STUDY DESIGN: Pancreatic cyst/duct fluid was prospectively collected from 100 patients with IPMN undergoing pancreatic resection. Surgical pathology revealed 47 low-/moderate-grade, 34 high-grade, and 20 invasive IPMNs. The PGE levels were assessed by ELISA and correlated with IPMN dysplasia grade, demographics, clinical radiologic/pathologic variables, acute/chronic pancreatitis, and NSAID use. RESULTS: Mean pancreatic cyst fluid PGE levels in high-grade and invasive IPMNs were significantly higher than low-/moderate-grade IPMNs (3.5 and 4.4 pg/µL, respectively, vs 1.2 pg/µL; p < 0.0016). At a threshold of 1.1 pg/µL, PGE was 63% sensitive, 79% specific, and 71% accurate for detection of high-grade/invasive IPMNs. When tested in the subset of IPMN patients with preoperative pancreatic cyst fluid CEA >192 ng/mL, PGE at a threshold of 0.5 pg/µL demonstrated 78% sensitivity, 100% specificity, and 86% accuracy for detection of high-grade/invasive IPMN. CONCLUSIONS: Our results validate pancreatic cyst fluid PGE as an indicator of IPMN dysplasia, especially in select patients with preoperative pancreatic cyst fluid CEA >192 ng/mL. The inclusion of PGE /CEA in a diagnostic biomarker panel can facilitate more optimal treatment stratification of IPMN patients.
[Mh] Termos MeSH primário: Adenocarcinoma Mucinoso/metabolismo
Carcinoma Ductal Pancreático/metabolismo
Dinoprostona/metabolismo
Neoplasias Pancreáticas/metabolismo
[Mh] Termos MeSH secundário: Adenocarcinoma Mucinoso/patologia
Adulto
Idoso
Biomarcadores/metabolismo
Carcinoma Ductal Pancreático/patologia
Estudos de Coortes
Líquido Cístico/metabolismo
Feminino
Seres Humanos
Masculino
Meia-Idade
Neoplasias Pancreáticas/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); K7Q1JQR04M (Dinoprostone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE


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[PMID]:28414889
[Au] Autor:Massimi L; Martelli C; Caldarelli M; Castagnola M; Desiderio C
[Ad] Endereço:Neurochirurgia Pediatrica, Università Cattolica del Sacro Cuore, Rome, Italy.
[Ti] Título:Proteomics in pediatric cystic craniopharyngioma.
[So] Source:Brain Pathol;27(3):370-376, 2017 May.
[Is] ISSN:1750-3639
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Adamantinomatous craniopharyngioma (ACP) is still often burdened by a poor prognosis in children as far as the risk of recurrence and the quality of life are concerned. Therefore, many efforts are now dedicated to investigate the molecular characteristics of this tumor aiming at finding new therapeutic options. ACP is prevalently a cystic lesion so that an increasing number of researches are focused on the analysis of its cystic content. In the present article, the main results of the current proteomic analysis (PA) on the ACP fluid are summarized. Both "bottom-up" and "top-down" approaches have been utilized. In the bottom-up approach, proteins and peptides are enzymatically or chemically digested prior to liquid chromatography and mass spectrometry analyses. The bottom-up approach pointed out several proteins of the inflammation (namely, α2-HS-glycoprotein, α1-antichymotrypsin and apolipoproteins) as possibly involved in the genesis and growth of the cystic component of ACP. The top-down strategy analyzes proteins and peptides in the intact state, making it particularly suitable for the identification of peptides and low molecular weight proteins and for the characterization of their possible isoforms and post-translational modifications. The top-down approach disclosed the presence of the thymosin ß family. Thymosin ß4, in particular, which is involved in the cytoskeleton organization and migration of several tumors, could play a role in the progression of ACP. Finally, PA was utilized to investigate alterations in cyst fluid character after treatment with interferon-α. The analyzed samples showed a progressive reduction of the levels of α-defensins (proteins involved in the inflammatory-mediated response) after the intracystic injection of interferon-α, thus reinforcing the hypothesis that inflammation contributes to ACP cyst pathogenesis. Additional studies on the solid component of ACP are still necessary to further validate the previous results and to identify possible markers for targeted therapy.
[Mh] Termos MeSH primário: Craniofaringioma/metabolismo
Neoplasias Hipofisárias/metabolismo
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Cromatografia Líquida de Alta Pressão
Estudos de Coortes
Líquido Cístico/metabolismo
Feminino
Seres Humanos
Masculino
Espectrometria de Massas
Projetos Piloto
Proteômica/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170418
[St] Status:MEDLINE
[do] DOI:10.1111/bpa.12502


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[PMID]:28411756
[Au] Autor:Basar O; Brugge WR
[Ad] Endereço:Pancreas Biliary Center, Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.
[Ti] Título:Pancreatic cyst guidelines: Which one to live by?
[So] Source:Gastrointest Endosc;85(5):1032-1035, 2017 05.
[Is] ISSN:1097-6779
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Cisto Pancreático
Neoplasias Pancreáticas
[Mh] Termos MeSH secundário: Líquido Cístico
Seres Humanos
[Pt] Tipo de publicação:EDITORIAL; COMMENT
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170417
[St] Status:MEDLINE


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[PMID]:28215775
[Au] Autor:Vege SS; Ziring B; Jain R; Scheiman JM; Hwang JH; Moayyedi P
[Ad] Endereço:Pancreas Interest Group, National Cancer Institute, Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
[Ti] Título:Optimal strategies for pancreatic cyst surveillance: we need better comparative data, not more case series.
[So] Source:Gastrointest Endosc;85(3):685-686, 2017 Mar.
[Is] ISSN:1097-6779
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Líquido Cístico
Cisto Pancreático
[Mh] Termos MeSH secundário: Seres Humanos
Neoplasias Pancreáticas
[Pt] Tipo de publicação:LETTER
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170221
[St] Status:MEDLINE


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[PMID]:28072692
[Au] Autor:Soyer OM; Baran B; Ormeci AC; Sahin D; Gokturk S; Evirgen S; Basar R; Firat P; Akyuz F; Demir K; Besisik F; Kaymakoglu S; Karaca C
[Ad] Endereço:aDepartment of Gastroenterohepatology bDepartment of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
[Ti] Título:Role of biochemistry and cytological analysis of cyst fluid for the differential diagnosis of pancreatic cysts: A retrospective cohort study.
[So] Source:Medicine (Baltimore);96(1):e5513, 2017 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Management of pancreatic cysts is based on neoplastic-nonneoplastic discrimination. Endoscopic ultrasound (EUS) enables to differentiate neoplastic-nonneoplastic lesions and also allows fine-needle aspiration (FNA). In this study, we aim to assess feasibility and clinical relevance of cytological and biochemical analysis in differential diagnosis of cystic pancreatic lesions in patients who had undergone endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) due to pancreatic cysts. METHODS: Participants were 96 patients who had undergone EUS-FNA for differential diagnosis of pancreatic cysts. Pancreatic cysts were classified as benign-mucinous, nonmucinous, and malignant according to patient history, physical examination, EUS appearance, and cystic fluid assessment. Tumor markers (CEA, CA(cancer antigens) 72.4, CA 19-9) , amylase, lipase and cytological assesment were compared between 3 different groups. Receiver-operating characteristics (ROC) curves were constructed to identify appropriate cut-off values. RESULTS: Fluid CEA and CA 72.4 levels for benign-mucinous and malignant cysts were significantly higher than for nonmucinous cysts (P ≤ 0.04). A cut-off CEA level of 207 ng/mL differentiated mucinous etiology with a sensitivity of 72.7%, specificity of 97.7%, and accuracy of 89.5%. The sensitivity, specificity, and accuracy of the CA 72.4 cut-off level of 3.32 ng/mL were 80%, 69.5%, and 73.6%, respectively. CONCLUSION: Cyst fluid CEA and CA 72.4 levels have a high accuracy in discriminating mucinous from nonmucinous cysts. When combined with cytology their accuracy rate increases.
[Mh] Termos MeSH primário: Antígenos Glicosídicos Associados a Tumores/análise
Antígeno Carcinoembrionário/análise
Líquido Cístico
Cisto Pancreático
Neoplasias Pancreáticas
[Mh] Termos MeSH secundário: Adulto
Idoso
Biomarcadores Tumorais/análise
Estudos de Coortes
Líquido Cístico/química
Líquido Cístico/metabolismo
Diagnóstico Diferencial
Aspiração por Agulha Fina Guiada por Ultrassom Endoscópico/métodos
Feminino
Seres Humanos
Masculino
Meia-Idade
Cisto Pancreático/química
Cisto Pancreático/diagnóstico
Cisto Pancreático/metabolismo
Cisto Pancreático/patologia
Neoplasias Pancreáticas/química
Neoplasias Pancreáticas/diagnóstico
Neoplasias Pancreáticas/metabolismo
Neoplasias Pancreáticas/patologia
Estudos Retrospectivos
Turquia
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Antigens, Tumor-Associated, Carbohydrate); 0 (Biomarkers, Tumor); 0 (CA-72-4 antigen); 0 (Carcinoembryonic Antigen)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170111
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000005513


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[PMID]:27647802
[Au] Autor:Rosenbaum MW; Jones M; Dudley JC; Le LP; Iafrate AJ; Pitman MB
[Ad] Endereço:Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts.
[Ti] Título:Next-generation sequencing adds value to the preoperative diagnosis of pancreatic cysts.
[So] Source:Cancer;125(1):41-47, 2017 Jan.
[Is] ISSN:1097-0142
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The diagnosis of a pancreatic cyst as mucinous or high-risk dictates the need for follow-up or surgery. Molecular analysis of aspirated pancreatic cyst fluid (PCF) can provide valuable information not obtained by carcinoembryonic antigen (CEA) analysis or cytology. METHODS: All patients who underwent molecular analysis of PCF between March 2013 and June 2015 were reviewed, including pathology, imaging, and follow-up. Molecular testing was performed using a patented, anchored multiplex polymerase chain reaction next-generation sequencing (NGS) platform, which sequenced numerous hotspots in 39 genes linked with malignancy. Performance of NGS and cytology was calculated using final outcome, as determined by clinicopathologic follow-up. RESULTS: The study cohort included 113 PCFs from 105 patients. In total, 119 variants were detected in 67 PCFs (59%). Variants were more common in intraductal papillary mucinous neoplasms (IPMNs)/cancer than in nonmucinous cysts (P < .005). The inclusion of v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS)/guanine nucleotide-binding protein (GNAS) variants improved the classification of IPMNs as mucinous from 50% by microscopy to 100%. Seventy-five percent of cancers had high-grade atypia versus 0% of IPMNs and nonmucinous cysts (P < .002). Variants in tumor protein 53 (TP53), SMAD family member 4 (SMAD4), cyclin-dependent kinase inhibitor 2A (CDKN2A), and notch1 (NOTCH1) were detected only in malignant cysts. Cytology was similarly specific (100%) for detecting malignant cysts but was more sensitive than the identification of late mutations by NGS (75% vs 46%). CONCLUSIONS: The detection of KRAS/GNAS variants improves the identification of mucinous neoplasms. Variants in TP53, SMAD4, CDKN2A, and NOTCH1 support the diagnosis of a high-risk cyst requiring surgery or additional sampling. Although molecular analysis is not a replacement for cytopathology, it does provide valuable information for accurate preoperative diagnosis, helping to classify mucinous neoplasms and high-risk cysts that require surgical resection. Cancer Cytopathol 2017;125:41-47. © 2016 American Cancer Society.
[Mh] Termos MeSH primário: Cistadenoma Mucinoso/diagnóstico
Citodiagnóstico
Sequenciamento de Nucleotídeos em Larga Escala
Cisto Pancreático/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Biomarcadores Tumorais/genética
Antígeno Carcinoembrionário/genética
Líquido Cístico/metabolismo
Cistadenoma Mucinoso/genética
Cistadenoma Mucinoso/cirurgia
Feminino
Seres Humanos
Masculino
Meia-Idade
Mutação
Proteínas de Neoplasias/genética
Cisto Pancreático/genética
Cisto Pancreático/patologia
Período Pré-Operatório
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (Carcinoembryonic Antigen); 0 (Neoplasm Proteins)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170529
[Lr] Data última revisão:
170529
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160921
[St] Status:MEDLINE
[do] DOI:10.1002/cncy.21775


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[PMID]:27646154
[Au] Autor:Yoshimoto C; Takahama J; Iwabuchi T; Uchikoshi M; Shigetomi H; Kobayashi H
[Ad] Endereço:Department of Obstetrics and Gynecology, Nara Medical University.
[Ti] Título:Transverse Relaxation Rate of Cyst Fluid Can Predict Malignant Transformation of Ovarian Endometriosis.
[So] Source:Magn Reson Med Sci;16(2):137-145, 2017 Apr 10.
[Is] ISSN:1880-2206
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Heme and iron accumulation due to repeated hemorrhage in endometriosis may contribute to a pivotal role in carcinogenesis. We evaluate the clinical application of MR relaxometry in a series of ovarian endometriosis (OE) and endometriosis-associated ovarian cancer (EAOC). MATERIALS AND METHODS: A prospective study of diagnostic accuracy was conducted among 82 patients (67 OE and 15 EAOC) to compare MR relaxometry and biochemical measurement of cyst fluid total iron concentration. Transverse relaxation rate R2 value was determined using a single-voxel, multi-echo MR sequence (HISTO) by a 3T-MR system. Phantom experiments were also performed to assess the correlation between the ex vivo R2 values and total iron concentrations. RESULTS: Both the results of phantom experiments and in vivo human data confirmed that in vivo R2 values were highly correlated with total iron concentrations. Compared to OE, EAOC exhibit decreased in vivo R2 values and total iron levels, regardless of their age, menopausal status and cyst size. The use of in vivo R2 values retained excellent accuracy in distinguishing EAOC versus OE (sensitivity and specificity: 86% and 94%). CONCLUSIONS: We have demonstrated that MR relaxometry provides a noninvasive predictive tool to discriminate between EAOC and OE.
[Mh] Termos MeSH primário: Transformação Celular Neoplásica/patologia
Líquido Cístico/metabolismo
Endometriose/patologia
Imagem por Ressonância Magnética
Neoplasias Ovarianas/patologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Transformação Celular Neoplásica/metabolismo
Estudos de Coortes
Endometriose/diagnóstico por imagem
Endometriose/metabolismo
Feminino
Seres Humanos
Ferro/metabolismo
Meia-Idade
Neoplasias Ovarianas/diagnóstico por imagem
Neoplasias Ovarianas/metabolismo
Valor Preditivo dos Testes
Estudos Prospectivos
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
E1UOL152H7 (Iron)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160921
[St] Status:MEDLINE
[do] DOI:10.2463/mrms.mp.2016-0028


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[PMID]:27609484
[Au] Autor:Oh SH; Lee JK; Lee KT; Lee KH; Woo YS; Noh DH
[Ad] Endereço:Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
[Ti] Título:The Combination of Cyst Fluid Carcinoembryonic Antigen, Cytology and Viscosity Increases the Diagnostic Accuracy of Mucinous Pancreatic Cysts.
[So] Source:Gut Liver;11(2):283-289, 2017 Mar 15.
[Is] ISSN:2005-1212
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:Background/Aims: The objective of this study was to investigate the value of cyst fluid carcinoembryonic antigen (CEA) in combination with cytology and viscosity for the differential diagnosis of pancreatic cysts. Methods: We retrospectively reviewed our data for patients who underwent endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) and cyst fluid analysis. We investigated the sensitivity, specificity and accuracy of the combination of cyst fluid CEA, cytology and viscosity testing. Results: A total of 177 patients underwent EUS-FNA and cyst fluid analysis. Of these, 48 subjects were histologically and clinically confirmed to have pancreatic cysts and were therefore included in the analysis. Receiver operator curve analysis demonstrated that the optimal cutoff value of cyst fluid CEA for differentiating mucinous versus nonmucinous cystic lesions was 48.6 ng/mL. The accuracy of cyst fluid CEA (39/48, 81.3%) was greater than the accuracy of cytology (23/45, 51.1%) or the string sign (33/47, 70.2%). Cyst fluid CEA in combination with cytology and string sign assessment exhibited the highest accuracy (45/48, 93.8%). Conclusions: Cyst fluid CEA was the most useful single test for identifying mucinous pancreatic cysts. The addition of cytology and string sign assessment to cyst fluid CEA increased the overall accuracy for the diagnosis of mucinous pancreatic cysts.
[Mh] Termos MeSH primário: Antígeno Carcinoembrionário
Líquido Cístico/citologia
Cistadenoma Mucinoso/diagnóstico
Cisto Pancreático/diagnóstico
Neoplasias Pancreáticas/diagnóstico
[Mh] Termos MeSH secundário: Área Sob a Curva
Diagnóstico Diferencial
Feminino
Seres Humanos
Masculino
Meia-Idade
Valor Preditivo dos Testes
Estudos Retrospectivos
Sensibilidade e Especificidade
Viscosidade
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carcinoembryonic Antigen)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160910
[St] Status:MEDLINE
[do] DOI:10.5009/gnl15650


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[PMID]:27750233
[Au] Autor:Takita M; Iwanishi M; Minami T; Kono M; Chishina H; Arizumi T; Yada N; Hagiwara S; Minami Y; Ida H; Ueshima K; Naoshi N; Kudo M
[Ti] Título:Monoethanolamine Oleate Sclerotherapy for Polycystic Liver Disease.
[So] Source:Dig Dis;34(6):654-658, 2016.
[Is] ISSN:1421-9875
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The objective of treatment for polycystic liver disease is to reduce the liver volume and reduce or resolve compression symptoms such as abdominal fullness and abdominal pain due to hepatomegaly. Liver cysts are treated internally by puncture and aspiration of the cyst contents or hepatic artery embolization and surgically by cyst fenestration or hepatectomy, but no clear consensus has been reached concerning their selection. We introduced monoethanolamine oleate (EO) sclerotherapy therapy for liver cysts in 1999 and reported its effectiveness. In this study, cases were added, and the results including those of long-term follow-up were evaluated. SUBJECTS: Twenty-two patients (5 males and 17 females, mean age 65.2) who underwent EO infusion therapy for liver cysts between January 1999 and June 2011 were evaluated. METHODS: Liver cysts were punctured under ultrasound guidance, and a 7Fr pigtail catheter was inserted. After aspirating the cyst contents, EO was infused, and a clamp was applied for 24 h. Then, the catheter was declamped, cyst contents were aspirated again, and the catheter was removed. After the treatment, the cyst size was measured, and the patients were followed up. RESULTS: Eight simple cysts in 8 patients (simple cyst group) and 21 cysts in 14 patients with multiple cysts (polycystic liver disease group) were treated and followed up over a median of 78 months (0-203 months). The mean volume reduction rate was 99% in the simple cyst group and 91% in the polycystic liver disease group (p = 0.04). One procedural accident resulting in liver abscess formation was observed in 1 patient 1 week after discharge, and it required drain placement and antibiotic administration. While mild abdominal pain was observed in a few patients, it was resolved spontaneously under observation. CONCLUSION: EO infusion therapy achieves fairly high treatment response in the volume reduction (99%) and sustained shrinkage over long-term follow-up. Therefore, this is a breakthrough technique in the treatment of polycystic liver disease as well as simple cyst and should be a standard of care in the treatment of this disease.
[Mh] Termos MeSH primário: Cistos/terapia
Hepatopatias/terapia
Ácidos Oleicos/uso terapêutico
Soluções Esclerosantes/uso terapêutico
Escleroterapia/métodos
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Líquido Cístico
Drenagem/métodos
Feminino
Seguimentos
Seres Humanos
Abscesso Hepático/etiologia
Abscesso Hepático/terapia
Estudos Longitudinais
Masculino
Meia-Idade
Ácidos Oleicos/administração & dosagem
Paracentese/métodos
Soluções Esclerosantes/administração & dosagem
Escleroterapia/efeitos adversos
Resultado do Tratamento
Ultrassonografia de Intervenção/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oleic Acids); 0 (Sclerosing Solutions); 0 (monoethanolamine oleate)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170117
[Lr] Data última revisão:
170117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161018
[St] Status:MEDLINE



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