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[PMID]:29267671
[Au] Autor:Lutfioglu M; Aydogdu A; Atabay VE; Sakallioglu EE; Avci B
[Ad] Endereço:Ondokuz Mayis University Faculty of Dentistry, Department of Periodontology, Samsun, Turkey.
[Ti] Título:Gingival crevicular fluid oxidative stress level in patients with periodontal disease and hyperlipidemia.
[So] Source:Braz Oral Res;31:e110, 2017 Dec 18.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:This study aimed to assess the impact of hyperlipidemia on healthy and diseased periodontal tissue by evaluating oxidative stress biomarkers in gingival crevicular fluid (GCF). Clinical periodontal parameters and blood serum lipid, GCF malondialdehyde (MDA), protein carbonyl (PC), and total antioxidant capacity (TAOC) levels were evaluated in six age and sex-matched groups (n = 15 each) of normolipidemic and hyperlipidemic individuals as follows: normolipidemic + periodontally healthy (H), normolipidemic + gingivitis (G), normolipidemic + chronic periodontitis (CP), hyperlipidemic + periodontally healthy (HH), hyperlipidemic + gingivitis (HG), and hyperlipidemic + CP (HCP). GCF MDA, and PC levels varied among groups, with patients with periodontitis having the highest MDA and PC levels [CP > G > H (p < 0.01) and HCP > HG > HH (p < 0.01)] and the lowest TAOC levels [CP < G < H (p < 0.01) and HCP < HG < HH (p < 0.01)]. Furthermore, paired comparisons showed MDA and PC levels to be higher and TAOC levels to be lower in HCP compared with NCP (p < 0.01). In patients with hyperlipidemia, GCF, MDA, and PC levels positively correlated with clinical assessments and serum triglycerides (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL) levels and negatively correlated with serum high-density lipoprotein cholesterol (HDL) levels, whereas GCF TAOC levels negatively correlated with clinical assessments and serum TG, TC, and LDL levels, but positively correlated with serum HDL levels (p < 0.01). In normolipidemic patients, GCF, MDA, and PC levels positively correlated with clinical assessments and serum TG levels and negatively correlated with serum HDL levels, whereas GCF TAOC levels negatively correlated with clinical assessments and serum TG levels and positively correlated with serum HDL levels (p < 0.01). In conclusion, abnormal serum lipid subfractions could be considered a risk factor for enhancing oxidative stress in GCF in the presence of periodontal disease.
[Mh] Termos MeSH primário: Periodontite Crônica/sangue
Líquido do Sulco Gengival/metabolismo
Gengivite/sangue
Hiperlipidemias/sangue
Estresse Oxidativo/fisiologia
[Mh] Termos MeSH secundário: Adulto
Análise de Variância
Estudos de Casos e Controles
Colesterol/sangue
Periodontite Crônica/etiologia
Ensaio de Imunoadsorção Enzimática
Feminino
Gengivite/etiologia
Seres Humanos
Hiperlipidemias/complicações
Masculino
Malondialdeído/sangue
Meia-Idade
Carbonilação Proteica/fisiologia
Valores de Referência
Estatísticas não Paramétricas
Triglicerídeos/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Triglycerides); 4Y8F71G49Q (Malondialdehyde); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


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[PMID]:29384870
[Au] Autor:Gao X; Zhou J; Sun X; Li X; Zhou Y
[Ad] Endereço:Department of Implantation, School of Stomatology, Jilin University, Changchun, Jilin, China.
[Ti] Título:Diversity analysis of subgingival microbial bacteria in peri-implantitis in Uygur population.
[So] Source:Medicine (Baltimore);97(5):e9774, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study is to investigate the subgingival bacterial diversity and community structure in the Uygur subjects with peri-implantitis.Totally 40 cases of gingival crevicular fluid were collected from Uygur subjects and divided into the Control group (healthy implants) and Case group (peri-implantitis), respectively. DNA was extracted, and the sequencing in the 16SrRNA V4-V5 region was conducted on the Illumina Miseq sequencing platform. The 16SrRNA gene clone library was constructed and analyzed.Totally 733,759 valid tags were obtained from these 40 samples. After comparing with the Silva-16S database by the Uparse software, 263 operational taxonomic unit were finally harvested (135 for the Control group and 128 for the Case group). The differential bacteria between these 2 groups at the phylum, class, order, family, and genus levels were Actinobacteria, Actinomycetes, Pasteurellales, Moraxellaceae, and Acinetobacter, respectively. The dominant genera with significantly different distribution between the Control and Case groups included Vibrio, Campylobacter, Granulicatella, Acinetobacter, Micrococcus, and Moraxella. The α diverstiy analysis based on the chao diversity index showed that there was significant difference in the microbiological diversity between these 2 groups. Principal coordinates analysis analysis indicated significant differences in the bacterial community structure between these 2 groups. Cluster analysis showed higher abundance of Micrococcus in the Case group, while higher abundance of Prevotella in the Control group.There are significant differences in the diversity of subgingival bacteria between the Uygur subjects with healthy implants and peri-implantitis. Moraxella, Micrococcus, and Acinetobacter might represent dominant bacteria genera causing peri-implantitis in the Uygur population.
[Mh] Termos MeSH primário: Bactérias/isolamento & purificação
Líquido do Sulco Gengival/microbiologia
Peri-Implantite/microbiologia
[Mh] Termos MeSH secundário: Adulto
Bactérias/classificação
Técnicas de Tipagem Bacteriana
Estudos de Casos e Controles
China
Feminino
Seres Humanos
Masculino
Microbiota
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009774


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[PMID]:29390529
[Au] Autor:Wang Y; Li W; Shi L; Zhang F; Zheng S
[Ad] Endereço:Department of Periodontology.
[Ti] Título:Comparison of clinical parameters, microbiological effects and calprotectin counts in gingival crevicular fluid between Er: YAG laser and conventional periodontal therapies: A split-mouth, single-blinded, randomized controlled trial.
[So] Source:Medicine (Baltimore);96(51):e9367, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The erbium-doped yttrium, aluminum, and garnet (Er:YAG) laser is thought to be the most promising laser for periodontal treatment; however, its application is still under consideration. The aim of this study was to compare Er:YAG laser monotherapy with conventional scaling and root planing (SRP) for chronic periodontitis using clinical parameters, the detection rate of periodontal pathogens, and the calprotectin level in gingival crevicular fluid. METHODS: Twenty-seven participants with moderate-to-advanced chronic periodontitis were included. In a split-mouth design, the 2 half-mouths of each participant were randomly assigned to Er:YAG laser or SRP (combination of ultrasonic and manual instruments) treatment. Clinical parameters were recorded at baseline, 6 weeks, and 3 and 6 months after treatment. At the same time points, gingival crevicular fluid was collected to analyze the detection rate of 6 periodontal pathogens by polymerase chain reaction and the levels of calprotectin by enzyme-linked immunosorbent assay. RESULTS: Both treatment groups showed significant reductions in probing depth (PD), bleeding index (BI), and clinical attachment level (CAL) from baseline to 6 months. For sites with 4 mm ≤ PD ≤ 6 mm at baseline, SRP resulted in a greater reduction in PD and CAL than Er:YAG laser treatment, and the difference remained at 6 months post-treatment (P = .01 and P < .01, respectively). For sites with PD ≥7 mm at baseline, the clinical parameters showed similar results between the 2 groups. SRP resulted in a lower detection rate of Porphyromonas gingivalis at 6 months post-treatment. The levels of calprotectin were significantly decreased from baseline to 6 months in both groups, without a significant difference between the groups. CONCLUSION: For mild pockets, conventional SRP may still be the preferred choice. For deep pockets, Er:YAG laser treatment could be an effective alternative. Studies are needed to explore more advanced instruments and new application methods for the Er:YAG laser for periodontal treatment in deep pockets.
[Mh] Termos MeSH primário: Periodontite Crônica/terapia
Líquido do Sulco Gengival/microbiologia
Lasers de Estado Sólido/uso terapêutico
Complexo Antígeno L1 Leucocitário/metabolismo
Bolsa Periodontal/radioterapia
Aplainamento Radicular/métodos
[Mh] Termos MeSH secundário: Adulto
Periodontite Crônica/diagnóstico
Terapia Combinada
Ensaio de Imunoadsorção Enzimática
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Índice Periodontal
Medição de Risco
Método Simples-Cego
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Leukocyte L1 Antigen Complex)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009367


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[PMID]:29328596
[Au] Autor:Stefanovic V; Taso E; Petkovic-Curcin A; Dukic M; Gardasevic M; Rakic M; Xavier S; Jovic M; Miller K; Stanojevic I; Vojvodic D
[Ti] Título:Influence of dental filling material type on the concentration of interleukin 9 in the samples of gingival crevicular fluid.
[So] Source:Vojnosanit Pregl;73(8):728-34, 2016 Aug.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Background/Aim: Several cytokines and lymphokines (IL1ß, ENA78, IL6, TNFα, IL8 and S100A8) are expressed during dental pulp inflammation. Analysis of gingival crevicu-lar fluid (GCF) offers a non-invasive means of studying gen-eral host response in oral cavity. Although GCF levels of various mediators could reflect the state of inflammation both in dental pulp and gingiva adjacent to a tooth, GCF samples of those without significant gingivitis could be inter-preted as reflection of pulpal process. The aim of this study was to investigate IL9 GCF values in patients with dental car-ies and to assess possible influence of various dental fillings materials on local IL9 production. Methods: The study group included 90 patients, aged 18­70, with inclusion and exclusion criteria in the prospective clinical study. Of the 6 types of material used for the restoration of prepared cavities, 3 were intended for temporary and 3 for definitive restora-tion. According to dental fillings weight, all the participants were divided into 3 groups: those with fillings lighter than 0.50 g, those with 0.50­1.00 g, and those with fillings heavier than 1.00 g. Samples were taken from gingival sulcus using the filter paper technique. Clinical parameters were deter-mined by bleeding index, plaque index (Silness-Lou, 0­3), gingival index (0­3), and gingival sulcus depth. Cytokine con-centrations were assessed using commercially available cy-tomix. Results: According to the weight of dental fillings, there was a clear decreament trend of IL9 values meaning that dental defects greater than 1.00 g of dental filling were associated with lower GCF IL9 concentration. The IL9 val-ues correlated with the degree of gingival index and depth of gingival sulcus, being higher with more advanced gingivitis and more pronounced anatomical changes in the tooth edge. Different filling materials exerted various local IL9 responses. Zink polycarbonate cement and amalgam fillings induced a significant and long-lasting local IL9 decrement, while the use of Tetric EvoCeram and GMA-BISK significantly increased IL9 levels. Conclusion: The obtained results indicate that IL9 GCF could be regarded as a measure of odontoblasts' re-sponse to the extensity of dental caries. The type of material used for dental fillings could profoundly alter biological func-tion of gingival and pulpal cells. Also, the results obtained in this study suggest that some materials could even enhance wound repair by modulating macrophage activation.
[Mh] Termos MeSH primário: Cárie Dentária/terapia
Materiais Dentários
Restauração Dentária Permanente/métodos
Restauração Dentária Temporária/métodos
Líquido do Sulco Gengival/metabolismo
Interleucina-9/metabolismo
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Cárie Dentária/metabolismo
Índice de Placa Dentária
Seres Humanos
Meia-Idade
Índice Periodontal
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dental Materials); 0 (IL9 protein, human); 0 (Interleukin-9)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.2298/VSP140227054S


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[PMID]:28962734
[Au] Autor:Zhang J; Zhang AM; Zhang ZM; Jia JL; Sui XX; Yu LR; Liu HT
[Ad] Endereço:Department of Stomatology, Dongying People's Hospital, Dongying, China. Electronic address: zhangjin2105@163.com.
[Ti] Título:Efficacy of combined orthodontic-periodontic treatment for patients with periodontitis and its effect on inflammatory cytokines: A comparative study.
[So] Source:Am J Orthod Dentofacial Orthop;152(4):494-500, 2017 Oct.
[Is] ISSN:1097-6752
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: In this study, we aimed to investigate the efficacy of combined orthodontic-periodontic treatment in the treatment of patients with periodontitis and its effects on the levels of inflammatory cytokines. METHODS: A total of 117 patients with periodontitis were randomly assigned to the basic group (receiving basic periodontic treatment, n = 58) and the combined group (receiving combined orthodontic-periodontic treatment, n = 59). In addition, 52 healthy people without periodontal disease were selected as the normal group. Probing depth, tooth mobility, plaque index, clinical attachment level, and sulcus bleeding index were recorded. ELISA was applied to detect gingival crevicular fluid (GCF) and serum levels of inflammatory cytokines. A 2-year clinical follow-up was conducted. RESULTS: Before treatment, the periodontal parameters (probing depth, tooth mobility, plaque index, clinical attachement level, and sulcus bleeding index) and GCF and serum levels of inflammatory cytokines (high-sensitivity C-reactive protein, interleukin-1ß, interleukin-5, interleukin-6, interleukin-8, tumor necrosis factor-α, and prostaglandin E2) in the combined and basic groups were higher than those in the normal group. After 6 and 18 months of treatment, the periodontal parameters and GCF and serum levels of inflammatory cytokines decreased in the combined and basic groups. The periodontal parameters and the GCF and serum levels of inflammatory cytokines in the combined group were significantly lower than those in the basic group after 18 months of treatment. The combined group had a lower recurrence rate compared with the basic group. CONCLUSIONS: Combined orthodontic-periodontic treatment had good clinical efficacy in the treatment of periodontitis and could effectively decrease the levels of inflammatory cytokines.
[Mh] Termos MeSH primário: Citocinas/análise
Líquido do Sulco Gengival/química
Periodontite/sangue
Periodontite/terapia
[Mh] Termos MeSH secundário: Adulto
Terapia Combinada
Citocinas/sangue
Feminino
Seres Humanos
Masculino
Meia-Idade
Ortodontia Corretiva
Periodontia
Periodontite/imunologia
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Cytokines)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:171001
[St] Status:MEDLINE


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[PMID]:28697211
[Au] Autor:Al Amri MD; Al-Rasheed AS; Al-Kheraif AA; Alfadda SA
[Ti] Título:Comparison of Clinical, Radiographic, and Immunologic Inflammatory Parameters Around Dental Implants with Cement-Retained and Screw-Retained Restorations: A 5-Year Prospective Cohort Study in Men.
[So] Source:Int J Prosthodont;30(4):384-389, 2017 Jul/Aug.
[Is] ISSN:0893-2174
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To compare bleeding on probing (BoP), probing depth (PD; ≥ 4 mm), radiographic (peri-implant crestal bone loss [CBL]), and immunologic inflammatory (interleukin-1beta [IL-1ß] and matrix metalloproteinase-9 [MMP-9]) parameters around dental implants with cement-retained (CR) and screw-retained (SR) implant-supported crowns. MATERIALS AND METHODS: Based on the mode of retention of the restoration, 51 patients were divided into two groups: Group 1, consisting of 26 single implants restored with CR crowns, and Group 2, consisting of 25 single implants restored with SR crowns. Peri-implant BoP, PD, and CBL were scored, and levels of IL-1ß and MMP-9 in the peri-implant crevicular fluid (PICF) in both groups were measured in duplicate using enzyme-linked immunosorbent assay. Full-mouth mechanical debridement was performed biannually in both groups. Statistical analysis was performed using Kruskal-Wallis test with the significance level set at P < .05. RESULTS: The mean CBL among implants in groups 1 and 2 was 1.7 ± 0.5 mm and 1.7 ± 0.4 mm, respectively. There was no statistically significant difference in mean BoP, PD, and CBL among implants in both groups (P > .05). There was no statistically significant difference between groups 1 and 2 in the PICF levels of IL-1ß (7.3 ± 0.5 and 7.2 ± 0.5, respectively) and MMP-9 (165 ± 9.4 and 182 ± 10.6, respectively) (P > .05). CONCLUSION: The mode of retention of implant-supported crowns does not appear to affect their clinical correlations with BoP, PD, CBL, and levels of IL-1ß and MMP-9 in the PICF when zinc oxide eugenol cement is used.
[Mh] Termos MeSH primário: Coroas
Implantação Dentária Endo-Óssea/métodos
Implantes Dentários para Um Único Dente
Prótese Dentária Fixada por Implante
Mediadores da Inflamação/metabolismo
[Mh] Termos MeSH secundário: Adulto
Parafusos Ósseos
Cimentação
Ensaio de Imunoadsorção Enzimática
Seguimentos
Gengiva/imunologia
Gengiva/patologia
Líquido do Sulco Gengival/química
Seres Humanos
Interleucina-1beta/metabolismo
Masculino
Metaloproteinase 9 da Matriz/metabolismo
Estudos Prospectivos
Radiografia Dentária
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Inflammation Mediators); 0 (Interleukin-1beta); EC 3.4.24.35 (Matrix Metalloproteinase 9)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170712
[St] Status:MEDLINE
[do] DOI:10.11607/ijp.5078


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[PMID]:28651765
[Au] Autor:Smuthkochorn S; Palomo JM; Hans MG; Jones CS; Palomo L
[Ad] Endereço:Private practice, Bangkok, Thailand. Electronic address: adplss@yahoo.com.
[Ti] Título:Gingival crevicular fluid bone turnover biomarkers: How postmenopausal women respond to orthodontic activation.
[So] Source:Am J Orthod Dentofacial Orthop;152(1):33-37, 2017 Jul.
[Is] ISSN:1097-6752
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Bone turnover associated with orthodontic tooth movement is evidenced by increased bone turnover markers in gingival crevicular fluid (GCF). Postmenopausal women have an increased concentration of serum bone turnover markers. The filtrate of this serum makes up GCF, but little is known of the bone turnover around teeth in this cohort. The objective of this investigation was to compare the GCF bone turnover markers in premenopausal vs postmenopausal women receiving orthodontic treatment at baseline and at orthodontic activation. METHODS: Twenty-eight women were enrolled in the study and separated into 2 groups: premenopausal (16) and postmenopausal (12). Bone turnover was evaluated by GCF at baseline and 24 hours after orthodontic appliance activation. GCF concentrations of RANKL and OPN were measured using ELISA. Baseline and change in concentrations were compared between groups. RESULTS: Baseline RANKL and OPN were significantly different between the premenopausal and postmenopausal groups (P <0.05). Both markers increased significantly from baseline to 24 hours after orthodontic appliance activation in both groups (P <0.05). However, the response to orthodontic activation was not significantly different between groups. CONCLUSIONS: Although postmenopausal women have a different bone turnover profile at baseline than do their premenopausal counterparts, there is no difference in their response to orthodontic activation. This confers a level of security associated with orthodontic activation. Future studies are warranted to construct biomarker curves throughout orthodontic therapy.
[Mh] Termos MeSH primário: Remodelação Óssea
Líquido do Sulco Gengival/química
Pós-Menopausa/fisiologia
Técnicas de Movimentação Dentária
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Biomarcadores/análise
Remodelação Óssea/fisiologia
Ensaio de Imunoadsorção Enzimática
Feminino
Seres Humanos
Meia-Idade
Osteopontina/análise
Ligante RANK/análise
Técnicas de Movimentação Dentária/efeitos adversos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (RANK Ligand); 0 (TNFSF11 protein, human); 106441-73-0 (Osteopontin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE


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[PMID]:28341818
[Au] Autor:Lavu V; Venkatesan V; Venugopal P; Lakkakula BV; Paul SF; Peria K; Rao SR
[Ad] Endereço:Department of Periodontics, Faculty of Dental Sciences, Sri Ramachandra University, Chennai, Tamil Nadu, India.
[Ti] Título:Clinical Relevance of Cytokines Gene Polymorphisms and Protein Levels in Gingival Cervical Fluid from Chronic Periodontitis Patients.
[So] Source:Iran J Immunol;14(1):51-58, 2017 Mar.
[Is] ISSN:1735-367X
[Cp] País de publicação:Iran
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cytokines are suggested to play a role in periodontitis. OBJECTIVES: To determine and compare the levels of Interleukin-1 beta (IL-1ß) and Tumor necrosis factor alpha (TNF-α) in gingival crevicular fluid (GCF) samples amongst healthy individuals and those with chronic periodontitis. Further to compare the GCF cytokine levels in three genotype classes defined by the respective gene polymorphisms. METHODS: The study was conducted on 41 chronic periodontitis patients and 40 healthy volunteers. IL-1ß and TNF-α were quantified in GCF by cytometric bead array. DNA was extracted from peripheral blood samples and genotyping of IL1B +3954C/T (rs1143634) IL1B -511G/A (rs16944), TNFA -1031T/C (rs1799964) and TNFA -863C/A (rs1800630) polymorphisms were performed using Sanger sequencing and Taqman SNP genotyping assays methods. RESULTS: Both IL-1ß and TNF-α levels were significantly higher in chronic periodontitis group compared to the controls. IL-1ß and TNF-α levels did not significantly differ in genotype classes of the respective polymorphism (IL1B -511G/A, TNFA -1031T/C and TNFA -863C/A). However, individuals with CT genotype of IL1B +3954C/T showed higher levels of IL-1ß in the gingival crevicular fluid (ANOVA p<0.05). CONCLUSION: The results of this study revealed the presence of higher levels of IL-1ß and TNF-α in subjects with periodontitis and genetic control of IL-1ß levels in our samples of Indians.
[Mh] Termos MeSH primário: Periodontite Crônica/genética
Líquido do Sulco Gengival/imunologia
Interleucina-1beta/genética
Fator de Necrose Tumoral alfa/genética
[Mh] Termos MeSH secundário: Periodontite Crônica/imunologia
Análise Mutacional de DNA
Regulação da Expressão Gênica
Frequência do Gene
Estudos de Associação Genética
Predisposição Genética para Doença
Genótipo
Seres Humanos
Índia
Polimorfismo de Nucleotídeo Único
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interleukin-1beta); 0 (Tumor Necrosis Factor-alpha)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170421
[Lr] Data última revisão:
170421
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170326
[St] Status:MEDLINE
[do] DOI:IJIv14i1A5


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[PMID]:28289894
[Au] Autor:Üretürk SE; Saraç M; Firatli S; Can SB; Güven Y; Firatli E
[Ad] Endereço:Department of Orthodontics, Faculty of Dentistry, Istanbul University, Istanbul, Turkey. sevinerol@gmail.com.
[Ti] Título:The effect of low-level laser therapy on tooth movement during canine distalization.
[So] Source:Lasers Med Sci;32(4):757-764, 2017 May.
[Is] ISSN:1435-604X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of the study is to determine the effects of low level laser therapy on tooth movement during canine distalization by evaluating IL-1ß, TGF-ß1 levels in gingival crevicular fluid. Maxillary first premolars of the 15 Angle Class II division I patients (12-19 years old) were extracted. Right maxillary canines were distalized by standard protocol as control group whereas the left maxillary canines distalized by laser application. A gallium-aluminum-arsenide diode laser with an output power of 20 mW was applied as five doses from the buccal and the palatal side on the day 0, and the 3rd, 7th, 14th, 21th 30th, 33st, 37th, 60th, 63th, and 67th days. Gingival crevicular fluid samples were obtained with filtration paper at the initial, 7th, 14th, and 21th days, and the IL-1ß and TGF-ß1 cytokine levels were analyzed. Orthodontic models and periodontal indices were taken initially and on the days 30th, 60th, and 90th of canine distalization period. Tooth movement was assessed by scanning models (3Shape). The amount of tooth movement in the laser group was 40% more than the control group. First day IL-1ß levels were statistically higher than initial and 21st day levels (P= 0.003, P = 0.012). The rise in IL-1ß levels caused the negative correlations between 7th day IL-1ß and 21st day TGF-ß1 levels describes the tissue effects of laser application. Periodontal indices showed no sign of gingival inflammation during canine distalization period. As conclusion, laser does accelerate tooth movement and could shorten the whole treatment duration.
[Mh] Termos MeSH primário: Dente Canino/efeitos da radiação
Terapia com Luz de Baixa Intensidade
Migração de Dente/radioterapia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Animais
Estudos de Casos e Controles
Placa Dentária/radioterapia
Feminino
Líquido do Sulco Gengival/metabolismo
Hemorragia/etiologia
Seres Humanos
Interleucina-1beta/metabolismo
Lasers Semicondutores/uso terapêutico
Masculino
Índice Periodontal
Fator de Crescimento Transformador beta1/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Interleukin-1beta); 0 (Transforming Growth Factor beta1)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170315
[St] Status:MEDLINE
[do] DOI:10.1007/s10103-017-2159-0


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[PMID]:28232938
[Au] Autor:de Aguiar MC; Perinetti G; Capelli J
[Ad] Endereço:Department of Orthodontics, Faculty of Dentistry, Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil.
[Ti] Título:The Gingival Crevicular Fluid as a Source of Biomarkers to Enhance Efficiency of Orthodontic and Functional Treatment of Growing Patients.
[So] Source:Biomed Res Int;2017:3257235, 2017.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Gingival crevicular fluid (GCF) is a biological exudate and quantification of its constituents is a current method to identify specific biomarkers with reasonable sensitivity for several biological events. Studies are being performed to evaluate whether the GCF biomarkers in growing subjects reflect both the stages of individual skeletal maturation and the local tissue remodeling triggered by orthodontic force. Present evidence is still little regarding whether and which GCF biomarkers are correlated with the growth phase (mainly pubertal growth spurt), while huge investigations have been reported on several GCF biomarkers (for inflammation, tissue damage, bone deposition and resorption, and other biological processes) in relation to the orthodontic tooth movement. In spite of these investigations, the clinical applicability of the method is still limited with further data needed to reach a full diagnostic utility of specific GCF biomarkers in orthodontics. Future studies are warranted to elucidate the role of main GCF biomarkers and how they can be used to enhance functional treatment, optimize orthodontic force intensity, or prevent major tissue damage consequent to orthodontic treatment.
[Mh] Termos MeSH primário: Biomarcadores/metabolismo
Líquido do Sulco Gengival/metabolismo
Crescimento e Desenvolvimento
Ortodontia
[Mh] Termos MeSH secundário: Criança
Seres Humanos
Técnicas de Movimentação Dentária
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170306
[Lr] Data última revisão:
170306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170225
[St] Status:MEDLINE
[do] DOI:10.1155/2017/3257235



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