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[PMID]:27772648
[Au] Autor:Nesper PL; Simjanoski E; Mirza RG
[Ad] Endereço:Department of Ophthalmology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.
[Ti] Título:Retinal Macroaneurysm in Long-Standing Hypertension.
[So] Source:Ophthalmology;123(11):2327, 2016 11.
[Is] ISSN:1549-4713
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Aneurisma/etiologia
Hipertensão/complicações
Artéria Retiniana/patologia
Doenças Retinianas/etiologia
[Mh] Termos MeSH secundário: Idoso
Aneurisma/diagnóstico por imagem
Arteríolas/diagnóstico por imagem
Arteríolas/patologia
Feminino
Angiofluoresceinografia
Seres Humanos
Artéria Retiniana/diagnóstico por imagem
Doenças Retinianas/diagnóstico por imagem
Hemorragia Retiniana/diagnóstico
Líquido Sub-Retiniano
Tomografia de Coerência Óptica
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:29204996
[Au] Autor:Curry B; Bylsma G; Hewitt AW; Verma N
[Ad] Endereço:Hobart Eye Surgeons, Hobart, Australia.
[Ti] Título:The VEGF Treatment of AMD Switch Study (The vTAS Study).
[So] Source:Asia Pac J Ophthalmol (Phila);6(6):481-487, 2017 Nov-Dec.
[Is] ISSN:2162-0989
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To evaluate the effect of aflibercept on anatomic and visual outcomes in patients with choroidal neovascularization (CNV) previously treated with intravitreal ranibizumab with persistent fluid on optical coherence tomography (OCT). DESIGN: Prospective, open-label study. METHODS: Eighteen patients (19 eyes) with CNV being treated with monthly ranibizumab, with persistent fluid on OCT, were switched to intravitreal aflibercept injections at intervals of up to 8 weeks. The primary outcome was the proportion of patients maintaining vision [<5 letter loss in visual acuity (VA)] at week 48. Secondary outcomes included the change in VA and central macular thickness (CMT) and the frequency of treatment necessary along with the safety of intravitreal aflibercept. RESULTS: Forty-eight weeks after switching to aflibercept, 16/19 eyes had maintained VA. There was a median increase in vision of 5 letters [interquartile range (IQR): 0, 15; = 0.06)] and median CMT was reduced from 313 µm (IQR: 214, 334) to 258 µm (IQR: 200, 299; = 0.02). After stratification by fluid location the reduction in CMT was statistically significant for eyes with intraretinal fluid (IRF) at baseline [median change, -25 µm (IQR: -14, -64); = 0.01]. Macular volume within 6 mm of the fovea (CMTVol) was significantly reduced in eyes with subretinal fluid (SRF) [-0.20 mm³ (IQR: -1.45, -0.05); = 0.03]. CONCLUSIONS: In this small cohort of eyes, switching to aflibercept seemed beneficial. The majority maintained or improved vision and eyes with IRF or SRF had significant reductions in macular edema. However, visual improvement was not always indicative of anatomical improvement.
[Mh] Termos MeSH primário: Inibidores da Angiogênese/uso terapêutico
Neovascularização de Coroide/tratamento farmacológico
Substituição de Medicamentos
Ranibizumab/uso terapêutico
Receptores de Fatores de Crescimento do Endotélio Vascular/uso terapêutico
Proteínas Recombinantes de Fusão/uso terapêutico
[Mh] Termos MeSH secundário: Idoso
Neovascularização de Coroide/patologia
Feminino
Seres Humanos
Injeções Intravítreas
Edema Macular/patologia
Masculino
Meia-Idade
Estudos Prospectivos
Líquido Sub-Retiniano/metabolismo
Tomografia de Coerência Óptica
Fator A de Crescimento do Endotélio Vascular/antagonistas & inibidores
Acuidade Visual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Angiogenesis Inhibitors); 0 (Recombinant Fusion Proteins); 0 (Vascular Endothelial Growth Factor A); 15C2VL427D (aflibercept); EC 2.7.10.1 (Receptors, Vascular Endothelial Growth Factor); ZL1R02VT79 (Ranibizumab)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.22608/APO.2017364


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[PMID]:28914005
[Au] Autor:Kim JM; Lee EJ; Cho GE; Bae K; Lee JY; Han G; Kang SW
[Ad] Endereço:Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
[Ti] Título:Delayed Absorption of Subretinal Fluid after Retinal Reattachment Surgery and Associated Choroidal Features.
[So] Source:Korean J Ophthalmol;31(5):402-411, 2017 Oct.
[Is] ISSN:2092-9382
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The aim of this study was to investigate the incidence and associated clinical factors of delayed absorption of subretinal fluid (SRF) after surgery for rhegmatogenous retinal detachment. METHODS: This study involved 36 eyes of 36 consecutive patients who underwent successful surgery for rhegmatogenous retinal detachment. A complete ophthalmologic evaluation, including clinical fundus examination, optical coherence tomography, and indocyanine green angiography, was conducted before and after surgery. Delayed absorption was defined as the presence of residual concave SRF or an SRF bleb at 6 months after surgery. Clinical factors and choroidal features on indocyanine green angiography were compared according to the presence and absence of delayed absorption. RESULTS: Eighteen of 36 eyes (50%) showed delayed absorption. Macular involvement and worse preoperative visual acuity were significantly related to the presence of delayed absorption (p = 0.001 and p = 0.034, respectively). On indocyanine green angiography, preoperative choroidal vascular hyperpermeability was noted in 70% of eyes with delayed absorption and in 14% of eyes without it (p = 0.010). CONCLUSIONS: Delayed absorption of SRF after retinal reattachment surgery was not rare, with a 50% of incidence in this study. Macula-off status was significantly related to the incidence of delayed SRF absorption, and choroidal features such as choroidal vascular hyperpermeability might be responsible in part, possibly through the resultant exudative property of choroid.
[Mh] Termos MeSH primário: Corioide/diagnóstico por imagem
Angiofluoresceinografia/métodos
Complicações Pós-Operatórias/epidemiologia
Descolamento Retiniano/cirurgia
Líquido Sub-Retiniano/metabolismo
Tomografia de Coerência Óptica/métodos
Acuidade Visual
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Feminino
Seguimentos
Fundo de Olho
Seres Humanos
Incidência
Macula Lutea/diagnóstico por imagem
Masculino
Meia-Idade
Complicações Pós-Operatórias/metabolismo
Prognóstico
República da Coreia/epidemiologia
Descolamento Retiniano/diagnóstico
Estudos Retrospectivos
Líquido Sub-Retiniano/diagnóstico por imagem
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170916
[St] Status:MEDLINE
[do] DOI:10.3341/kjo.2016.0033


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[PMID]:28837729
[Au] Autor:Vogl WD; Waldstein SM; Gerendas BS; Schlegl T; Langs G; Schmidt-Erfurth U
[Ad] Endereço:Computational Imaging Research Lab, Department of Biomedical Imaging and Image-guided Therapy, Medical University Vienna, Austria.
[Ti] Título:Analyzing and Predicting Visual Acuity Outcomes of Anti-VEGF Therapy by a Longitudinal Mixed Effects Model of Imaging and Clinical Data.
[So] Source:Invest Ophthalmol Vis Sci;58(10):4173-4181, 2017 Aug 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: We develop a longitudinal statistical model describing best-corrected visual acuity (BCVA) changes in anti-VEGF therapy in relation to imaging data, and predict the future BCVA outcome for individual patients by combining population-wide trends and initial subject-specific time points. Methods: Automatic segmentation algorithms were used to measure intraretinal (IRF) and subretinal (SRF) fluid volume on monthly spectral-domain optical coherence tomography scans of eyes with central retinal vein occlusion (CRVO) receiving standardized anti-VEGF treatment. The trajectory of BCVA over time was modeled as a multivariable repeated-measure mixed-effects regression model including fluid volumes as covariates. Subject-specific BCVA trajectories and final treatment outcomes were predicted using a population-wide model and individual observations from early follow-up. Results: A total of 193 eyes (one per patient, 12-month follow-up, 2420 visits) were analyzed. The population-wide mixed model revealed that the impact of fluid on BCVA is highest for IRF in the central millimeter around the fovea, with -31.17 letters/mm3 (95% confidence interval [CI], -39.70 to -23.32), followed by SRF in the central millimeter, with -17.50 letters/mm3 (-31.17 to -4.60) and by IRF in the parafovea, with -2.87 letters/mm3 (-4.71 to -0.44). The influence of SRF in the parafoveal area was -1.24 letters/mm3 (-3.37-1.05). The conditional R2 of the model, including subject-specific deviations, was 0.887. The marginal R2 considering the population-wide trend and fluid changes was 0.109. BCVA at 1 year could be predicted for an individual patient after three visits with a mean absolute error of six letters and a predicted R2 of 0.658 using imaging information. Conclusions: The mixed-effects model revealed that retinal fluid volumes and population-wide trend only explains a small proportion of the variation in BCVA. Individual BCVA outcomes after 1 year could be predicted from initial BCVA and fluid measurements combined with the population-wide model. Accounting for fluid in the predictive model increased prediction accuracy.
[Mh] Termos MeSH primário: Inibidores da Angiogênese/uso terapêutico
Modelos Estatísticos
Ranibizumab/uso terapêutico
Oclusão da Veia Retiniana/tratamento farmacológico
Fator A de Crescimento do Endotélio Vascular/antagonistas & inibidores
Acuidade Visual/fisiologia
[Mh] Termos MeSH secundário: Idoso
Ensaios Clínicos como Assunto
Bases de Dados Factuais
Feminino
Seguimentos
Seres Humanos
Injeções Intravítreas
Masculino
Meia-Idade
Oclusão da Veia Retiniana/diagnóstico
Oclusão da Veia Retiniana/fisiopatologia
Líquido Sub-Retiniano/fisiologia
Tomografia de Coerência Óptica
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Angiogenesis Inhibitors); 0 (VEGFA protein, human); 0 (Vascular Endothelial Growth Factor A); ZL1R02VT79 (Ranibizumab)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170825
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-21878


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[PMID]:28813577
[Au] Autor:Klimscha S; Waldstein SM; Schlegl T; Bogunovic H; Sadeghipour A; Philip AM; Podkowinski D; Pablik E; Zhang L; Abramoff MD; Sonka M; Gerendas BS; Schmidt-Erfurth U
[Ad] Endereço:Christian Doppler Laboratory for Ophthalmic Image Analysis, Vienna Reading Center, Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria.
[Ti] Título:Spatial Correspondence Between Intraretinal Fluid, Subretinal Fluid, and Pigment Epithelial Detachment in Neovascular Age-Related Macular Degeneration.
[So] Source:Invest Ophthalmol Vis Sci;58(10):4039-4048, 2017 Aug 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To identify the spatial distribution of exudative features of choroidal neovascularization in neovascular age-related macular degeneration (nAMD) based on the localization of intraretinal cystoid fluid (IRC), subretinal fluid (SRF), and pigment-epithelial detachment (PED). Methods: This retrospective cross-sectional study included spectral-domain optical coherence tomography volume scans (6 × 6 mm) of 1341 patients with treatment-naïve nAMD. IRC, SRF, and PED were detected on a per-voxel basis using fully automated segmentation algorithms. Two subsets of 37 volumes each were manually segmented to validate the automated results. The spatial correspondence of components was quantified by computing proportions of IRC-, SRF-, or PED-presenting A-scans simultaneously affected by the respective other pathomorphologic components on a per-patient basis. The median across the population is reported. Odds ratios between pairs of lesions were calculated and tested for significance pixel wise. Results: Automated image segmentation was successful in 1182 optical coherence tomography volumes, yielding more than 61 million A-scans for analysis. Overall, 81% of eyes showed IRC, 95% showed SRF, and 92% showed PED. IRC-presenting A-scans also showed SRF in a median 2.5%, PED in 32.9%. Of the SRF-presenting A-scans, 0.3% demonstrated IRC, 1.4% PED. Of the PED-presenting A-scans, 5.2% contained IRC, 2.0% SRF. Similar patterns were observed in the manually segmented subsets and via pixel-wise odds ratio analysis. Conclusions: Automated analyses of large-scale datasets in a cross-sectional study of 1182 patients with active treatment-naïve nAMD demonstrated low spatial correlation of SRF with IRC and PED in contrast to increased colocalization of IRC and PED. These morphological associations may contribute to our understanding of functional deficits in nAMD.
[Mh] Termos MeSH primário: Neovascularização de Coroide/diagnóstico
Edema Macular/diagnóstico
Descolamento Retiniano/diagnóstico
Epitélio Pigmentado da Retina/patologia
Líquido Sub-Retiniano
Degeneração Macular Exsudativa/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Inibidores da Angiogênese/uso terapêutico
Neovascularização de Coroide/tratamento farmacológico
Neovascularização de Coroide/fisiopatologia
Ensaios Clínicos como Assunto
Estudos Transversais
Feminino
Seres Humanos
Injeções Intravítreas
Masculino
Ranibizumab/uso terapêutico
Estudos Retrospectivos
Tomografia de Coerência Óptica
Fator A de Crescimento do Endotélio Vascular/antagonistas & inibidores
Acuidade Visual/fisiologia
Degeneração Macular Exsudativa/tratamento farmacológico
Degeneração Macular Exsudativa/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Angiogenesis Inhibitors); 0 (VEGFA protein, human); 0 (Vascular Endothelial Growth Factor A); ZL1R02VT79 (Ranibizumab)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170817
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.16-20201


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[PMID]:28669776
[Au] Autor:Kawashima Y; Hata M; Oishi A; Ooto S; Yamashiro K; Tamura H; Miyata M; Uji A; Ueda-Arakawa N; Tsujikawa A
[Ad] Endereço:Department of Ophthalmology and Visual Sciences, Kyoto University Graduate, School of Medicine, Kyoto, Japan.
[Ti] Título:Association of Vascular Versus Avascular Subretinal Hyperreflective Material With Aflibercept Response in Age-related Macular Degeneration.
[So] Source:Am J Ophthalmol;181:61-70, 2017 Sep.
[Is] ISSN:1879-1891
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To investigate flow signal within subretinal hyperreflective material (SHRM) using optical coherence tomography angiography (OCTA) and its association with aflibercept treatment responses in treatment-naïve neovascular age-related macular degeneration (nAMD). DESIGN: Prospective consecutive interventional case series. METHODS: Forty-four eyes of 44 patients with treatment-naïve nAMD manifesting SHRM on OCT were studied. All patients underwent OCTA and received 3 monthly aflibercept injections. The intrinsic flow signals within SHRM were quantitatively analyzed using OCTA, and eyes were classified into the vascular and avascular SHRM groups. RESULTS: Of 44 eyes, 21 (47.7%) and 23 (52.3%) showed vascular SHRM and avascular SHRM, respectively. Compared with eyes with avascular SHRM, eyes with vascular SHRM showed higher rates of external limiting membrane (ELM) disruption owing to SHRM (P = .015), classic choroidal neovascularization (CNV) (85.7% vs 26.1%, P = .87 × 10 ), and intraretinal fluid (P = .008) at baseline. After 3 aflibercept injections, 38 eyes (86.4%) showed dry macula despite persistent SHRM in 24 eyes (54.5%). Compared with the eyes with resolved SHRM, those with persistent SHRM showed higher rate of vascular SHRM (75.0% vs 15.0%, P = .86 × 10 ), classic CNV (P = .032), absence of polypoidal lesion (P = .020), ELM disruption owing to SHRM (P = .042), and intraretinal fluid (P = .008). Dry macula after loading injections was significantly associated with SHRM resolution (P = .025). CONCLUSIONS: In nAMD, SHRM can be categorized as vascular and avascular by quantitative OCTA analysis. Vascular SHRM persisted after treatment and was associated with failure to achieve dry macula, suggesting that vascular SHRM is predictive of lower response to anti-VEGF therapy.
[Mh] Termos MeSH primário: Inibidores da Angiogênese/uso terapêutico
Matriz Extracelular/patologia
Receptores de Fatores de Crescimento do Endotélio Vascular/uso terapêutico
Proteínas Recombinantes de Fusão/uso terapêutico
Vasos Retinianos/patologia
Degeneração Macular Exsudativa/diagnóstico
Degeneração Macular Exsudativa/tratamento farmacológico
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Biomarcadores
Feminino
Angiofluoresceinografia
Seres Humanos
Injeções Intravítreas
Masculino
Estudos Prospectivos
Líquido Sub-Retiniano
Tomografia de Coerência Óptica
Fator A de Crescimento do Endotélio Vascular/antagonistas & inibidores
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Angiogenesis Inhibitors); 0 (Biomarkers); 0 (Recombinant Fusion Proteins); 0 (VEGFA protein, human); 0 (Vascular Endothelial Growth Factor A); 15C2VL427D (aflibercept); EC 2.7.10.1 (Receptors, Vascular Endothelial Growth Factor)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170704
[St] Status:MEDLINE


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[PMID]:28660277
[Au] Autor:Bogunovic H; Waldstein SM; Schlegl T; Langs G; Sadeghipour A; Liu X; Gerendas BS; Osborne A; Schmidt-Erfurth U
[Ad] Endereço:Christian Doppler Laboratory for Ophthalmic Image Analysis, Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.
[Ti] Título:Prediction of Anti-VEGF Treatment Requirements in Neovascular AMD Using a Machine Learning Approach.
[So] Source:Invest Ophthalmol Vis Sci;58(7):3240-3248, 2017 Jun 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: The purpose of this study was to predict low and high anti-VEGF injection requirements during a pro re nata (PRN) treatment, based on sets of optical coherence tomography (OCT) images acquired during the initiation phase in neovascular AMD. Methods: Two-year clinical trial data of subjects receiving PRN ranibizumab according to protocol specified criteria in the HARBOR study after three initial monthly injections were included. OCT images were analyzed at baseline, month 1, and month 2. Quantitative spatio-temporal features computed from automated segmentation of retinal layers and fluid-filled regions were used to describe the macular microstructure. In addition, best-corrected visual acuity and demographic characteristics were included. Patients were grouped into low and high treatment categories based on first and third quartile, respectively. Random forest classification was used to learn and predict treatment categories and was evaluated with cross-validation. Results: Of 317 evaluable subjects, 71 patients presented low (≤5), 176 medium, and 70 high (≥16) injection requirements during the PRN maintenance phase from month 3 to month 23. Classification of low and high treatment requirement subgroups demonstrated an area under the receiver operating characteristic curve of 0.7 and 0.77, respectively. The most relevant feature for prediction was subretinal fluid volume in the central 3 mm, with the highest predictive values at month 2. Conclusions: We proposed and evaluated a machine learning methodology to predict anti-VEGF treatment needs from OCT scans taken during treatment initiation. The results of this pilot study are an important step toward image-guided prediction of treatment intervals in the management of neovascular AMD.
[Mh] Termos MeSH primário: Inibidores da Angiogênese/uso terapêutico
Neovascularização de Coroide/diagnóstico por imagem
Neovascularização de Coroide/tratamento farmacológico
Aprendizado de Máquina
Degeneração Macular/diagnóstico por imagem
Degeneração Macular/tratamento farmacológico
Ranibizumab/uso terapêutico
Tomografia de Coerência Óptica/métodos
Fator A de Crescimento do Endotélio Vascular/antagonistas & inibidores
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Masculino
Meia-Idade
Projetos Piloto
Valor Preditivo dos Testes
Curva ROC
Líquido Sub-Retiniano/diagnóstico por imagem
Acuidade Visual
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Angiogenesis Inhibitors); 0 (Vascular Endothelial Growth Factor A); ZL1R02VT79 (Ranibizumab)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.16-21053


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[PMID]:28241322
[Au] Autor:Lee H; Jo A; Kim HC
[Ad] Endereço:Department of Ophthalmology, Konkuk University Medical Center, Seoul, Republic of Korea.
[Ti] Título:Three-Dimensional Analysis of Morphologic Changes and Visual Outcomes in Neovascular Age-Related Macular Degeneration.
[So] Source:Invest Ophthalmol Vis Sci;58(2):1337-1345, 2017 Feb 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To investigate the association of three-dimensionally quantified lesions with best-corrected visual acuity (BCVA) in typical neovascular age-related macular degeneration (nAMD). Methods: We retrospectively analyzed 65 eyes of 61 typical nAMD patients. Lesions at baseline and month 12 were manually delineated in optical coherence tomography. The volume of intraretinal fluid (IRF), subretinal fluid (SRF), subretinal hyperreflective material (SHRM), and pigment epithelial detachment (PED) were measured. In addition, the areas of external limiting membrane (ELM) and ellipsoid zone (EZ) were calculated. Results: At baseline, poor baseline BCVA was associated with increased volume of IRF and SHRM and impaired area of ELM (ß = 0.34, P = 0.001; ß = 0.46, P < 0.001; and ß = -0.23, P = 0.03, respectively). At month 12, poor BCVA was associated with increased volume of IRF, reduced intact ELM area, and decreased EZ area (ß = 0.24, P = 0.01; ß = -0.30, P = 0.02; and ß = -0.37, P = 0.004, respectively). Baseline BCVA, volume of IRF, and intact area of ELM were significant predictors for BCVA at month 12 (ß = 0.29, P = 0.01; ß = 0.30, P = 0.01; and ß = -0.28, P = 0.01). Changes of BCVA were associated with changes of SHRM volume, intact EZ area, and ELM area (ß = 0.35, P = 0.002; ß = -0.28, P = 0.01; and ß = -0.22, P = 0.048, respectively). The predictive power of volumetric analysis was higher than that of qualitative analysis (R2 = 0.47 vs. R2 = 0.37). The volume of SRF and fibrovascular PED showed positive and negative effect on visual outcome each, but they were not strong enough to remain in multivariate model. Conclusions: Best-corrected visual acuity could be explained by three-dimensional optical coherence tomography morphology to a fair degree. In addition, three-dimensional analysis could predict visual outcomes better than qualitative analysis.
[Mh] Termos MeSH primário: Retina/patologia
Degeneração Macular Exsudativa/patologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Imagem Tridimensional
Masculino
Meia-Idade
Análise de Regressão
Descolamento Retiniano/patologia
Epitélio Pigmentado da Retina/patologia
Estudos Retrospectivos
Líquido Sub-Retiniano/diagnóstico por imagem
Tomografia de Coerência Óptica/métodos
Acuidade Visual
Degeneração Macular Exsudativa/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170615
[Lr] Data última revisão:
170615
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170228
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.16-20637


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[PMID]:28237171
[Au] Autor:Al-Awadi A; Mandelcorn ED; Somani S
[Ad] Endereço:Wayne State University School of Medicine, Detroit, Mich.
[Ti] Título:Atypical transient subretinal exudation following photodynamic therapy for chronic central serous retinopathy: a case report.
[So] Source:Can J Ophthalmol;52(1):e38-e41, 2017 Feb.
[Is] ISSN:1715-3360
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Coriorretinopatia Serosa Central/tratamento farmacológico
Fotoquimioterapia/efeitos adversos
Descolamento Retiniano/etiologia
Epitélio Pigmentado da Retina/patologia
Acuidade Visual
[Mh] Termos MeSH secundário: Coriorretinopatia Serosa Central/diagnóstico
Doença Crônica
Feminino
Angiofluoresceinografia
Fundo de Olho
Seres Humanos
Meia-Idade
Fotoquimioterapia/métodos
Fármacos Fotossensibilizantes/efeitos adversos
Fármacos Fotossensibilizantes/farmacologia
Descolamento Retiniano/diagnóstico
Líquido Sub-Retiniano
Tomografia de Coerência Óptica
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Photosensitizing Agents)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170227
[St] Status:MEDLINE


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[PMID]:28233895
[Au] Autor:Giuffrè C; Carnevali A; Codenotti M; Corbelli E; De Vitis LA; Querques L; Bandello F; Querques G
[Ad] Endereço: Department of Ophthalmology, IRCCS Ospedale San Raffaele, University Vita-Salute, Milan - Italy.
[Ti] Título:Persistent subretinal fluid mimicking central serous retinopathy after scleral buckling surgery: possible vortex vein compression role.
[So] Source:Eur J Ophthalmol;27(2):e54-e56, 2017 Mar 10.
[Is] ISSN:1724-6016
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To describe the case of a woman who developed persistent subretinal fluid in the macular region after the placement of encircling band for retinal detachment surgery, possibly due to vortex vein compression. METHODS: Case report. RESULTS: A 66-year-old woman diagnosed with central serous retinopathy presented with poor vision and metamorphopsia in the left eye (LE). Her visual acuity had deteriorated to 20/100 in LE after retinal detachment surgery with scleral buckling 8 months before. Multimodal imaging including fundus autofluorescence and fluorescein angiography disclosed a gravitational hyperfluorescent area involving the macular region that appeared to originate from the superotemporal quadrant in correspondence with the buckling. This area corresponded to a serous retinal detachment on structural spectral-domain optical coherence tomography (SD-OCT). Interestingly, on indocyanine green angiography, the encircling band of the scleral buckling appeared located at the emergence of the superotemporal vortex vein. Based on these findings, the patient was diagnosed with gravitational serous retinal detachment secondary to vortex vein compression. Successful rapid visual recovery and decrease of retinal fluid on SD-OCT was achieved with prompt surgery of scleral buckling removal, confirming the diagnosis. CONCLUSIONS: Choroidal veins can be obliterated during retinal detachment surgery, especially when retinal breaks are posterior to the equator. Indocyanine green angiography is the gold standard to study choroidal circulation and in our case allowed us to visualize the compression of the superotemporal vortex vein at the site of scleral buckling.
[Mh] Termos MeSH primário: Coriorretinopatia Serosa Central/diagnóstico
Corioide/irrigação sanguínea
Hiperemia/etiologia
Recurvamento da Esclera/efeitos adversos
Líquido Sub-Retiniano
[Mh] Termos MeSH secundário: Idoso
Remoção de Dispositivo
Feminino
Angiofluoresceinografia
Seres Humanos
Hiperemia/diagnóstico
Descolamento Retiniano/cirurgia
Tomografia de Coerência Óptica/métodos
Trombose Venosa/diagnóstico
Trombose Venosa/etiologia
Acuidade Visual
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170330
[Lr] Data última revisão:
170330
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170225
[St] Status:MEDLINE



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