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Pesquisa : A13.395.248 [Categoria DeCS]
Referências encontradas : 565 [refinar]
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[PMID]:28514936
[Au] Autor:Fujiyama M; Sano H; Chambers JP; Gieseg M
[Ad] Endereço:a Massey University Veterinary Teaching Hospital , Tennent Drive, Palmerston North 4442 , New Zealand.
[Ti] Título:Evaluation of an indirect oscillometric blood pressure monitor in anaesthetised dogs at three different anatomical locations.
[So] Source:N Z Vet J;65(4):185-191, 2017 Jul.
[Is] ISSN:1176-0710
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: To evaluate the agreement between invasive and non-invasive measurements of blood pressure (BP) using an oscillometer (PetTrust) at three different anatomical locations in anaesthetised dogs under different haemodynamic conditions. METHODS: Eight adult Greyhounds weighing 23.5-36.5 kg were anaesthetised with isoflurane and positioned in dorsal recumbency. Systolic arterial pressure (SAP), diastolic arterial pressure (DAP) and mean arterial pressure (MAP) were measured invasively via a dorsal pedal artery and non-invasively using the oscillometer with cuffs placed above the carpus, above the tarsus and around the tail base. Phenylephrine was administered to induce vasoconstriction, dobutamine was used to increase cardiac output and increased end-tidal concentrations of isoflurane were used to induce vasodilation. Correlation between measurements was analysed by linear regression and agreement was analysed using Bland-Altman plots. RESULTS: Seventy two representative measurements were obtained. Mean differences (bias) between invasive and non-invasive measurements were <5 mmHg except for DAP measured on the tail, and SD (precision) were <15 mm Hg except for SAP measured at the pelvic limb. Correlation coefficients were >0.9 except for SAP on the pelvic limb and DAP on the tail. More than 50 and 80% of values measured using oscillometry lay within 10 and 20 mmHg, respectively, of values measured invasively except for SAP on the tail. SAP tended to be overestimated when measured non-invasively at low BP, and be underestimated at high BP. DAP was underestimated during low BP and overestimated during high BP. Hypotension (MAP <60 mmHg) was detected by the oscillometer with a sensitivity ≥83% and specificity ≥98% at all locations. CONCLUSIONS: This oscillometric device met the 2007 American College of Veterinary Internal Medicine guidelines for measurement of BP on the thoracic limb. There was good agreement between the oscillometer and invasive measurement of MAP at all locations. CLINICAL RELEVANCE: MAP is the driving pressure for tissue perfusion, thus MAP measurement is clinically essential. This oscillometric device yields reliable MAP measurements at three anatomical locations over a wide range of BP and can identify hypotension with high sensitivity and specificity.
[Mh] Termos MeSH primário: Determinação da Pressão Arterial/veterinária
Doenças do Cão/diagnóstico
Hipotensão/veterinária
Oscilometria/veterinária
[Mh] Termos MeSH secundário: Animais
Pressão Arterial
Determinação da Pressão Arterial/instrumentação
Determinação da Pressão Arterial/métodos
Cardiotônicos/administração & dosagem
Carpo Animal/fisiologia
Cães
Feminino
Hipotensão/diagnóstico
Modelos Lineares
Masculino
Oscilometria/métodos
Fenilefrina/administração & dosagem
Sensibilidade e Especificidade
Cauda/fisiologia
Tarso Animal/fisiologia
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cardiotonic Agents); 1WS297W6MV (Phenylephrine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170519
[St] Status:MEDLINE
[do] DOI:10.1080/00480169.2017.1295000


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[PMID]:28441054
[Au] Autor:King MR; Haussler KK; Kawcak CE; McIlwraith CW; Reiser RF; Frisbie DD; Werpy NM
[Ti] Título:Biomechanical and histologic evaluation of the effects of underwater treadmill exercise on horses with experimentally induced osteoarthritis of the middle carpal joint.
[So] Source:Am J Vet Res;78(5):558-569, 2017 May.
[Is] ISSN:1943-5681
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE To evaluate the effects of exercise in an underwater treadmill (UWT) on forelimb biomechanics and articular histologic outcomes in horses with experimentally induced osteoarthritis of the middle carpal joint. ANIMALS 16 horses. PROCEDURES An osteochondral fragment was induced arthroscopically (day 0) in 1 middle carpal joint of each horse. Beginning on day 15, horses were assigned to exercise in a UWT or in the UWT without water (simulating controlled hand walking) at the same speed, frequency, and duration. Thoracic and pelvic limb ground reaction forces, thoracic limb kinematics, and electromyographic results for select thoracic limb muscles acting on the carpi were collected on days -7 (baseline), 14, 42, and 70. Weekly evaluations included clinical assessments of lameness, response to carpal joint flexion, and goniometric measurements of thoracic limb articulations. At study conclusion, articular cartilage and synovial membrane from the middle carpal joints was histologically examined. RESULTS Exercise in a UWT significantly reduced synovial membrane inflammation and resulted in significant clinical improvements with regard to symmetric thoracic limb loading, uniform activation patterns of select thoracic limb muscles, and return to baseline values for carpal joint flexion, compared with results for horses with simulated hand walking. CONCLUSIONS AND CLINICAL RELEVANCE Overall improvements in thoracic limb function, joint range of motion, and synovial membrane integrity indicated that exercise in a UWT was a potentially viable therapeutic option for the management of carpal joint osteoarthritis in horses.
[Mh] Termos MeSH primário: Carpo Animal
Terapia por Exercício/veterinária
Doenças dos Cavalos/terapia
Osteoartrite/veterinária
Caminhada
[Mh] Termos MeSH secundário: Animais
Fenômenos Biomecânicos
Carpo Animal/patologia
Cartilagem Articular/patologia
Extremidades
Membro Anterior/patologia
Doenças dos Cavalos/patologia
Cavalos
Coxeadura Animal/patologia
Coxeadura Animal/terapia
Osteoartrite/patologia
Osteoartrite/terapia
Amplitude de Movimento Articular
Membrana Sinovial
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170426
[St] Status:MEDLINE
[do] DOI:10.2460/ajvr.78.5.558


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[PMID]:27752779
[Au] Autor:Xu G; Su R; Lv J; Lai X; Li X; Wu J; Hu B; Xu L; Shen R; Gu J; Yu X
[Ad] Endereço:National Key Disciplines, Department of Forensic Pathology, Shantou University Medical College, Shantou, Guangdong Province, People's Republic of China.
[Ti] Título:Anterior wrist and medial malleolus: the optimal sites for tissue selection in electric death through hand-to-foot circuit pathway.
[So] Source:Int J Legal Med;131(2):433-439, 2017 Mar.
[Is] ISSN:1437-1596
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Specific morphological changes may be absent in some cases of electrocution shocked by the voltage of 220 V or lower. In this study, we attempted to demonstrate that the anterior wrist and medial malleolus were the optimal sites with promising and significant changes in electric death through the hand-to-foot circuit pathway. We established an electric shock rat model and observed histopathologic changes in the anterior wrist and medial malleolus. The results showed that the current intensities in the left anterior wrist and right medial malleolus were remarkably higher than those in the other sites, and the nuclei long/short (L/S) axis ratios of the arterial endotheliocyte and the skeletal muscle cell in these two areas were significantly higher than those in other parts of the body. These findings suggested that the anterior wrist and/or medial malleolus soft tissues as the narrowest parts of the limbs could be used as promising and useful sites for the assessment of electrical shock death, especially in forensic pathologic evaluation.
[Mh] Termos MeSH primário: Carpo Animal/patologia
Traumatismos por Eletricidade/patologia
Tarso Animal/patologia
[Mh] Termos MeSH secundário: Animais
Aorta Abdominal/patologia
Artérias/patologia
Células Endoteliais/patologia
Patologia Legal
Modelos Animais
Músculo Esquelético/patologia
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161019
[St] Status:MEDLINE
[do] DOI:10.1007/s00414-016-1474-5


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[PMID]:27493282
[Au] Autor:Ree JJ; Baltzer WI; Townsend KL
[Ad] Endereço:Department of Clinical Sciences, Oregon State University, 172 Magruder Hall, Corvallis, Oregon 97331, USA.
[Ti] Título:Augmentation of arthrodesis in dogs using a free autogenous omental graft.
[So] Source:Can Vet J;57(8):835-41, 2016 Aug.
[Is] ISSN:0008-5286
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:A technique for using free autogenous omental grafting with arthrodesis in dogs is described and radiographic osseous union and complications after surgery are evaluated. This retrospective study matched body weight and procedure type for 8 cases of pancarpal arthrodesis, 4 cases of pantarsal arthrodesis, and 2 cases of partial tarsal arthrodesis in dogs with omental and cancellous bone autograft (OBG group) and with cancellous bone autograft alone (BG group). Radiographs were reviewed 9 to 12 weeks after surgery to compare scores of radiographic osseous union and it was found that the OBG group had higher scores than the BG group. The BG group had significantly more major complications that required re-operation for implant removal or treatment of a deep infection compared to the OBG group. Overall, free autogenous omental grafts may be used to augment arthrodesis in dogs without significant morbidity and further investigation of its use to reduce major complications and speed bone healing are warranted.
[Mh] Termos MeSH primário: Artrodese/veterinária
Doenças do Cão/cirurgia
Omento/transplante
[Mh] Termos MeSH secundário: Animais
Artrodese/efeitos adversos
Doenças Ósseas/cirurgia
Doenças Ósseas/veterinária
Carpo Animal/cirurgia
Cães
Estudos Retrospectivos
Tarso Animal/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160806
[St] Status:MEDLINE


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[PMID]:27198611
[Au] Autor:Smith AD; Morton AJ; Winter MD; Colahan PT; Ghivizzani S; Brown MP; Hernandez JA; Nickerson DM
[Ad] Endereço:Department of Large Animal Clinical Sciences, University of Florida College of Veterinary Medicine, University of Florida, Gainesville, FL, 32608.
[Ti] Título:MAGNETIC RESONANCE IMAGING SCORING OF AN EXPERIMENTAL MODEL OF POST-TRAUMATIC OSTEOARTHRITIS IN THE EQUINE CARPUS.
[So] Source:Vet Radiol Ultrasound;57(5):502-14, 2016 Sep.
[Is] ISSN:1740-8261
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Magnetic resonance imaging (MRI) is the most sensitive imaging modality to detect the early changes of osteoarthritis. Currently, there is no quantifiable method to tract these pathological changes over time in the horse. The objective of this experimental study was to characterize the progression of MRI changes in an equine model of post-traumatic osteoarthritis using a semiquantitative scoring system for whole-organ evaluation of the middle carpal joint. On day 0, an osteochondral fragment was created in one middle carpal joint (OCI) and the contralateral joint (CON) was sham-operated in 10 horses. On day 14, study horses resumed exercise on a high-speed treadmill until the completion of the study (day 98). High-field MRI examinations were performed on days 0 (preosteochondral fragmentation), 14, and 98 and scored by three blinded observers using consensus agreement. Images were scored based on 15 independent articular features, and scores were compared between and within-groups. On days 14 and 98, OCI joints had significantly (P ≤ 0.05) higher whole-organ median scores (29.0 and 31.5, respectively), compared to CON joints (21.5 and 20.0, respectively). On day 14, OCI joints showed significant increases in high-signal bone lesion scores, and osteochondral fragment number and size. On day 98, high-signal bone lesion, low-signal bone lesion, osteophyte formation, cartilage signal abnormality, subchondral bone irregularity, joint effusion, and synovial thickening scores were significantly increased in OCI joints. Study results suggest that the MRI whole-organ scoring system reported here may be used to identify onset and progression of pathological changes following osteochondral injury.
[Mh] Termos MeSH primário: Articulações do Carpo/diagnóstico por imagem
Doenças dos Cavalos/diagnóstico por imagem
Imagem por Ressonância Magnética/veterinária
Osteoartrite/veterinária
[Mh] Termos MeSH secundário: Animais
Carpo Animal/diagnóstico por imagem
Feminino
Doenças dos Cavalos/etiologia
Cavalos
Imagem por Ressonância Magnética/métodos
Masculino
Osteoartrite/diagnóstico por imagem
Osteoartrite/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170902
[Lr] Data última revisão:
170902
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160521
[St] Status:MEDLINE
[do] DOI:10.1111/vru.12369


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[PMID]:27007492
[Au] Autor:Ramirez JM; Macias C
[Ad] Endereço:Centro Veterinario de Referencia Bahia de Malaga, Malaga, Spain.
[Ti] Título:Pancarpal Arthrodesis Without Rigid Coaptation Using the Hybrid Dynamic Compression Plate in Dogs.
[So] Source:Vet Surg;45(3):303-8, 2016 Apr.
[Is] ISSN:1532-950X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To describe the complications, short- and long-term outcomes, and owner satisfaction for dogs treated with pancarpal arthrodesis (PCA) using the 2.7/3.5 mm locking and dynamic compression plate (DCP) hybrid pancarpal arthrodesis plate (hybrid DCP [HDCP]) without rigid coaptation in the postoperative period. STUDY DESIGN: Retrospective case series. ANIMALS: Dogs with carpal injuries requiring PCA (n=15). METHODS: Records (May 2007-October 2013) of dogs that had PCA using 3.5/2.7 mm HDCP (1 or 2 plates) and a Robert-Jones bandage were reviewed to determine intra- and post-operative complications and overall limb function. Follow-up was obtained by clinical evaluation at our institution and telephone interview of owners. RESULTS: Fourteen dogs had PCA stabilized with a single HDCP and 1 giant breed dog had PCA stabilized with 2 HDCP on the dorsal aspect of the carpus secured onto the 3rd and 4th metacarpal bones. Two dogs presented with bilateral injuries. Thirteen owners (87%) judged the results of surgery as excellent and 2 (13%) judged the results of surgery as good. Minor complications (4 limbs; 23%) were occasional episodes of mild lameness in 3 dogs and 3 episodes of discharging sinus tracts in a single dog. Major complications (3 limbs; 17%) included 1 surgical site infection and implant failure in a 43 kg dog with an active leishmaniasis infection and a concurrent bilateral sacro-iliac luxation. Two dogs developed episodes of discharging sinus tract and pain over the most distal screw that eventually necessitated plate removal. CONCLUSION: PCA without rigid coaptation can successfully be performed using the HDCP.
[Mh] Termos MeSH primário: Placas Ósseas/veterinária
Parafusos Ósseos/veterinária
Carpo Animal/lesões
Cães/lesões
Marcha
[Mh] Termos MeSH secundário: Animais
Artrodese/veterinária
Carpo Animal/cirurgia
Cães/cirurgia
Feminino
Entrevistas como Assunto
Masculino
Período Pós-Operatório
Amplitude de Movimento Articular
Estudos Retrospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160324
[St] Status:MEDLINE
[do] DOI:10.1111/vsu.12458


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[PMID]:26898661
[Au] Autor:Badawy AM; Marzok MA; Eshra EA
[Ad] Endereço:Adel Badawy, Faculty of Veterinary Medicine, Veterinary Surgery, Radiology and Anesthesiology, Toukh, Qaliobia, 13747, Egypt, E-mail: adelbadawybadawy@yahoo.com.
[Ti] Título:Computed tomographic arthrography of the normal dromedary camel carpus.
[So] Source:Vet Comp Orthop Traumatol;29(3):188-94, 2016 May 18.
[Is] ISSN:0932-0814
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The aim of this prospective cadaveric study was to provide a detailed computed tomographic (CT) reference of the carpal joint in healthy dromedary camels. Twelve forelimbs of six apparently healthy camels were used. Computed tomographic imaging of 12 normal cadaveric camel carpal joints was performed before and after intra-articular administration of iodinated contrast medium. Transverse CT images were reconstructed in dorsal and parasagittal planes. The six carpal bones, the radial trochlea, and the proximal articular surface of the metacarpal bones were clearly visible on CT images with the bone setting window. Radiocarpal, carpometacarpal, transverse intercarpal, medial and lateral palmer intercarpal, middle intercarpal, accessory carpoulnar and medial and lateral collateral ligaments, carpal canal, joint capsule, and the extensor and flexor tendons were identified on CT images with the soft-tissue setting window. Postcontrast CT images provided better delineation of intercarpal ligaments, the capsular compartments and recesses. Results indicated that the osseous and the clinically important soft tissue structures of the dromedary camel carpal joint could be identified using CT and CT arthrography. The CT data of this study will serve as a basis for diagnosis of carpal problems in camels.
[Mh] Termos MeSH primário: Camelus/anatomia & histologia
Carpo Animal/anatomia & histologia
[Mh] Termos MeSH secundário: Animais
Artrografia/veterinária
Carpo Animal/diagnóstico por imagem
Feminino
Membro Anterior
Masculino
Estudos Prospectivos
Valores de Referência
Tomografia Computadorizada por Raios X/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170412
[Lr] Data última revisão:
170412
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160223
[St] Status:MEDLINE
[do] DOI:10.3415/VCOT-15-06-0112


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[PMID]:26144555
[Au] Autor:Brenninkmeyer C; Dippel S; Brinkmann J; March S; Winckler C; Knierim U
[Ad] Endereço:1Farm Animal Behaviour and Husbandry Section,University of Kassel,Nordbahnhofstraße 1a,37213 Witzenhausen,Germany.
[Ti] Título:Investigating integument alterations in cubicle housed dairy cows: which types and locations can be combined?
[So] Source:Animal;10(2):342-8, 2016 Feb.
[Is] ISSN:1751-732X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study, a data set of 2922 lactating dairy cows in a sample of 64 conventional and organic dairy farms with Holstein Friesian cows in Germany and 31 conventional dairy farms with the dual purpose breed Fleckvieh in Austria was used to screen for correlations between the occurrences of different integument alterations. All cows were housed in cubicle systems. Alterations were classified as hairless areas (H), scabs or wounds (W) or swellings (S) and assessed at 15 locations of the cows' body. Highest median farm prevalences were found at the joints of the legs, which are already commonly included in studies on integumentary alterations: median farm prevalence was 83% for S and 48% for H at the carpal joints, followed by H (38%) and S (20%) at the lateral tarsal joints and H at the lateral calcanei (20%). Additional body parts with notable median prevalences for H were the hip bones (13%), pin bones (12%) and sacrum (11%). Three cluster models, with 2, 5 and 14 clusters, were built by hierarchical clustering of prevalences of the 30 most relevant alteration location combinations. Clustering revealed that location overruled type of lesion in most cases. Occasionally, clusters represented body segments significantly distant from each other, for example the carpal joints and lateral and dorsal calcanei. However, some neighbouring areas such as the medial and lateral hock area should be analysed separately from each other for causal analysis as they formed distinct clusters.
[Mh] Termos MeSH primário: Bovinos/lesões
Bovinos/fisiologia
Abrigo para Animais/classificação
Pele/lesões
Ferimentos e Lesões/veterinária
[Mh] Termos MeSH secundário: Bem-Estar do Animal
Animais
Áustria
Cruzamento
Carpo Animal/lesões
Carpo Animal/patologia
Análise por Conglomerados
Indústria de Laticínios
Feminino
Alemanha
Abrigo para Animais/normas
Lactação
Prevalência
Pele/patologia
Tarso Animal/lesões
Tarso Animal/patologia
Ferimentos e Lesões/epidemiologia
Ferimentos e Lesões/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160118
[Lr] Data última revisão:
160118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150707
[St] Status:MEDLINE
[do] DOI:10.1017/S1751731115001032


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[PMID]:26263182
[Au] Autor:Mählmann K; Koch C; Bodó G
[Ad] Endereço:Department of Clinical Veterinary Science, Swiss Institute for Equine Medicine, Vetsuisse Faculty University of Berne and ALP-Haras Avenches, Germany.
[Ti] Título:Diagnostic endoscopy of the navicular bursa using a needle endoscope by direct or transthecal approach: A comparative cadaver study.
[So] Source:Vet Surg;44(7):816-24, 2015 Oct.
[Is] ISSN:1532-950X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To compare the practicability, visualization of structures, and iatrogenic damage of direct and transthecal approaches to the navicular bursa for diagnostic needle endoscopy. STUDY DESIGN: Descriptive study. SAMPLE POPULATION: Equine cadaver forelimbs (n = 30). METHODS: Direct and transthecal approaches for insertion of a needle endoscope into the navicular bursa were performed. Video recordings of endoscopic procedures were assessed to determine all structures visualized within the navicular bursa. Number of attempts to gain access to the navicular bursa and total time for insertion and examination were recorded. Distribution and severity of iatrogenic lesions were assessed and scored after dissection. RESULTS: There were no statistical differences for number of attempts or time needed for insertion and examination between direct and transthecal approaches. The direct approach offered significantly increased visibility of the ipsilateral abaxial and proximal margins of the navicular bone, and ipsilateral collateral sesamoidean ligament. Iatrogenic lesions were superficial and focal, regardless of approach taken, or whether a blunt or sharp trocar tip was used. CONCLUSIONS: The direct approach provided significantly better visualization of the ipsilateral structures within the navicular bursa compared to the transthecal approach. Needle endoscopy offers a reliable technique to evaluate the navicular bursa and may complement or replace other diagnostic modalities in horses with lameness localized to the navicular region.
[Mh] Termos MeSH primário: Bolsa Sinovial/cirurgia
Carpo Animal/cirurgia
Endoscopia/métodos
Endoscopia/veterinária
Cavalos/cirurgia
[Mh] Termos MeSH secundário: Animais
Cadáver
Endoscopia/instrumentação
Agulhas
Gravação em Vídeo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1607
[Cu] Atualização por classe:151005
[Lr] Data última revisão:
151005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150812
[St] Status:MEDLINE
[do] DOI:10.1111/vsu.12369


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[PMID]:26207965
[Au] Autor:Jackson BF; Reed SR; Price JS; Verheyen KL
[Ti] Título:Relationship between serum biomarkers of cartilage and bone metabolism and joint injury in young Thoroughbred racehorses in training.
[So] Source:Am J Vet Res;76(8):679-87, 2015 Aug.
[Is] ISSN:1943-5681
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To compare serum concentrations of biomarkers of cartilage and bone metabolism between racehorses with a carpal or metacarpophalangeal or metatarsophalangeal (ie, fetlock) joint injury and matched uninjured control horses, determine changes in biomarker concentrations following joint injury, and establish the biomarkers' diagnostic test performance. ANIMALS: 50 Thoroughbred racehorses with a carpal or fetlock joint injury and 50 matched uninjured horses (control horses). PROCEDURES: Serum concentrations of 2 cartilage synthesis biomarkers (carboxy-terminal propeptide of type II collagen [CPII] and chondroitin sulfate epitope 846 [CS846]), 2 cartilage degradation biomarkers (neoepitope generated by collagenase cleavage of type II collagen [C2C] and cross-linked carboxy-terminal telopeptide fragments of type II collagen [CTX-II]), and serum activity of a bone formation marker (bone-specific alkaline phosphatase [BAP]) were measured around the time of injury diagnosis and monthly thereafter for as long as possible. RESULTS: Injured horses as a group and horses specifically with fetlock joint injuries had significantly lower serum CPII concentrations and significantly higher serum BAP activities than matched control horses. Concentrations of CTX-II were decreased between 2 and 4 months following joint injury. Measurement of CPII concentration at baseline could distinguish between injured horses and control horses with a sensitivity of 82% and specificity of 50%. CONCLUSIONS AND CLINICAL RELEVANCE: Although significant differences in specific biomarker concentrations between horses with carpal and fetlock joint injuries and matched control horses were identified, there was no convincing evidence of the suitability of these biomarkers as diagnostic or prognostic tools in a clinical setting.
[Mh] Termos MeSH primário: Biomarcadores/sangue
Doenças dos Cavalos/sangue
Cavalos/lesões
Articulações/lesões
Osteocondrite/veterinária
[Mh] Termos MeSH secundário: Animais
Carpo Animal/lesões
Estudos de Casos e Controles
Colágeno Tipo II/sangue
Articulações/metabolismo
Coxeadura Animal
Osteocondrite/sangue
Condicionamento Físico Animal
Sensibilidade e Especificidade
Articulações Tarsianas/lesões
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biomarkers); 0 (Collagen Type II)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:150725
[Lr] Data última revisão:
150725
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150725
[St] Status:MEDLINE
[do] DOI:10.2460/ajvr.76.8.679



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