Base de dados : MEDLINE
Pesquisa : A13.507 [Categoria DeCS]
Referências encontradas : 619 [refinar]
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[PMID]:28509635
[Au] Autor:Smith JS; Angelos JA; Chigerwe M
[Ti] Título:Disorders of performance-age bucking bulls.
[So] Source:J Am Vet Med Assoc;250(11):1302-1307, 2017 Jun 01.
[Is] ISSN:1943-569X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE To describe disorders of performance-age bucking bulls. DESIGN Retrospective case-control study. ANIMALS 78 bucking (cases) and 236 nonbucking (controls) beef bulls. PROCEDURES The medical record database of a referral hospital was reviewed to identify beef bulls > 1 year old that were examined for a medical or musculoskeletal disorder between January 1, 2000, and April 1, 2014. Bucking bulls were designated as cases, and nonbucking bulls were designated as controls. For each bull, the signalment, history, physical examination and diagnostic test results, and clinical diagnosis were recorded. The frequency of each disorder was compared between cases and controls. RESULTS Fifteen of 78 (19%) cases and 132 of 236 (56%) controls had medical disorders; however, the frequency did not differ between the 2 groups for any medical disorder. Musculoskeletal disorders were identified in 55 (70.5%) cases and 109 (46%) controls. Cases were 10.55 times as likely as controls to have horn and sinus disorders. Of the 43 (55%) cases examined because of lameness, the thoracic limb was affected in 19 (44%). Compared with controls, cases were 13.37 and 3.31 times as likely to have a musculoskeletal disorder of the vertebral region and pelvic limb, respectively. CONCLUSIONS AND CLINICAL RELEVANCE Results indicated bucking bulls were more likely than nonbucking bulls to develop horn and sinus disorders and musculoskeletal disorders of the vertebral region and pelvic limbs. The limb distribution of lameness for bucking bulls may differ from that for nonbucking bulls.
[Mh] Termos MeSH primário: Doenças dos Bovinos/epidemiologia
Artropatias/veterinária
Condicionamento Físico Animal
[Mh] Termos MeSH secundário: Animais
California/epidemiologia
Estudos de Casos e Controles
Bovinos
Doenças dos Bovinos/diagnóstico
Membro Anterior
Membro Posterior
Cornos/anormalidades
Artropatias/diagnóstico
Artropatias/epidemiologia
Coxeadura Animal/diagnóstico
Masculino
Encaminhamento e Consulta
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170517
[St] Status:MEDLINE
[do] DOI:10.2460/javma.250.11.1302


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[PMID]:28382983
[Au] Autor:Cheung H; Wong RW; Biggs D
[Ad] Endereço:University of Queensland, Brisbane, Australia.
[Ti] Título:Ivory ban: Close Hong Kong's ivory-trade window.
[So] Source:Nature;544(7648):35, 2017 04 05.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Comércio/legislação & jurisprudência
Conservação dos Recursos Naturais/legislação & jurisprudência
Elefantes/anatomia & histologia
Espécies em Perigo de Extinção/legislação & jurisprudência
Cornos
[Mh] Termos MeSH secundário: Animais
Comércio/economia
Conservação dos Recursos Naturais/economia
Espécies em Perigo de Extinção/economia
Hong Kong
[Pt] Tipo de publicação:LETTER
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170703
[Lr] Data última revisão:
170703
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE
[do] DOI:10.1038/544035b


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[PMID]:28117676
[Au] Autor:Zhai Y; Zhu Z; Zhu Y; Qian D; Liu R; Peng Y; Ding Y; Ouyang Z; Duan JA
[Ad] Endereço:Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China. zhaiyanj
[Ti] Título:Characterization of Collagen Peptides in Elaphuri Davidiani Cornu Aqueous Extract with Proliferative Activity on Osteoblasts Using Nano-Liquid Chromatography in Tandem with Orbitrap Mass Spectrometry.
[So] Source:Molecules;22(1), 2017 Jan 20.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:First documented in (about 200 B.C.-200 A.D.), (EDC) has been recorded for its effects in strengthening bones and balancing other aspects of overall health for approximately 2000 years. In the present study, our aim was to investigate which are the components of the active EDC fraction by a peptidomic strategy. We explored the extent to which EDC increases the proliferation of osteoblasts by measuring the elevations in osteonectin and type I collagen mRNA levels and characterized it using nano-flow liquid chromatography in tandem with orbitrap mass spectrometry. In total, 272 peptide sequences from collagens were determined. "Hot regions" in parent proteins determined by peptide heat maps which indicated that amino acid sequences in the regions might undergo proteolysis easily and generate peptides. Among the identified peptides, 90.2% were hydrophilic, and the molecular weight of 97.1% of identified peptides was lower than 2000 Da. According to these results, EDC collagen-derived peptides were easily analyzed and identified. Moreover, this methodology is feasible to characterize the active peptides matrices originated from collagen hydrolysates or some other animal horn- derived TCMs.
[Mh] Termos MeSH primário: Proliferação Celular/efeitos dos fármacos
Colágeno Tipo I/farmacologia
Cornos/química
Osteoblastos/efeitos dos fármacos
Osteonectina/metabolismo
Hidrolisados de Proteína/farmacologia
Extratos de Tecidos/farmacologia
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Sobrevivência Celular/efeitos dos fármacos
Células Cultivadas
Cromatografia Líquida de Alta Pressão/métodos
Colágeno Tipo I/genética
Colágeno Tipo I/metabolismo
Cervos
Medicina Tradicional Chinesa
Osteonectina/genética
Ratos
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Collagen Type I); 0 (Osteonectin); 0 (Protein Hydrolysates); 0 (Tissue Extracts); 0 (collagen type I, alpha 1 chain)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170523
[Lr] Data última revisão:
170523
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE


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[PMID]:27793720
[Au] Autor:Johnson KL; Trim MW; Francis DK; Whittington WR; Miller JA; Bennett CE; Horstemeyer MF
[Ad] Endereço:Department of Mechanical Engineering, Mississippi State University, Mississippi State, MS 39762, USA; Center for Advanced Vehicular Systems (CAVS), 200 Research Blvd, Mississippi State, MS 39762, USA. Electronic address: kljohnsonmsu@gmail.com.
[Ti] Título:Moisture, anisotropy, stress state, and strain rate effects on bighorn sheep horn keratin mechanical properties.
[So] Source:Acta Biomater;48:300-308, 2017 Jan 15.
[Is] ISSN:1878-7568
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This paper investigates the effects of moisture, anisotropy, stress state, and strain rate on the mechanical properties of the bighorn sheep (Ovis Canadensis) horn keratin. The horns consist of fibrous keratin tubules extending along the length of the horn and are contained within an amorphous keratin matrix. Samples were tested in the rehydrated (35wt% water) and ambient dry (10wt% water) conditions along the longitudinal and radial directions under tension and compression. Increased moisture content was found to increase ductility and decrease strength, as well as alter the stress state dependent nature of the material. The horn keratin demonstrates a significant strain rate dependence in both tension and compression, and also showed increased energy absorption in the hydrated condition at high strain rates when compared to quasi-static data, with increases of 114% in tension and 192% in compression. Compressive failure occurred by lamellar buckling in the longitudinal orientation followed by shear delamination. Tensile failure in the longitudinal orientation occurred by lamellar delamination combined with tubule pullout and fracture. The structure-property relationships quantified here for bighorn sheep horn keratin can be used to help validate finite element simulations of ram's impacting each other as well as being useful for other analysis regarding horn keratin on other animals. STATEMENT OF SIGNIFICANCE: The horn of the bighorn sheep is an anisotropic composite composed of keratin that is highly sensitive to moisture content. Keratin is also found in many other animals in the form of hooves, claws, beaks, and feathers. Only one previous study contains high rate experimental data, which was performed in the dry condition and only in compression. Considering the bighorn sheep horns' protective role in high speed impacts along with the moisture and strain rate sensitivity, more high strain rate data is needed to fully characterize and model the material. This study provides high strain rate results demonstrating the effects of moisture, anisotropy, and stress state. As a result, the comprehensive data allows modeling efforts to be greatly improved.
[Mh] Termos MeSH primário: Cornos/química
Umidade
Queratinas/química
Estresse Mecânico
[Mh] Termos MeSH secundário: Animais
Anisotropia
Fenômenos Biomecânicos
Força Compressiva
Cornos/ultraestrutura
Processamento de Imagem Assistida por Computador
Carneiro da Montanha
Estatística como Assunto
Resistência à Tração
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
68238-35-7 (Keratins)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161107
[St] Status:MEDLINE


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[PMID]:27932732
[Au] Autor:Harwood D; Perkins N; Dustan B
[Ad] Endereço:Goat Veterinary Society, Tarn Farm Vets, Shap, Cumbria CA10 3NB; e-mail: gvs.enquiries@gmail.com.
[Ti] Título:Disbudding goat kids.
[So] Source:Vet Rec;179(23):606, 2016 Dec 10.
[Is] ISSN:2042-7670
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Animais Recém-Nascidos/cirurgia
Cabras/cirurgia
Cornos/cirurgia
[Mh] Termos MeSH secundário: Animais
Legislação Veterinária
Sociedades
Reino Unido
Gravação em Vídeo
[Pt] Tipo de publicação:LETTER
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161210
[St] Status:MEDLINE
[do] DOI:10.1136/vr.i6558


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[PMID]:27870917
[Au] Autor:Haas TC; Ferreira SM
[Ad] Endereço:Lubar School of Business, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, United States of America.
[Ti] Título:Combating Rhino Horn Trafficking: The Need to Disrupt Criminal Networks.
[So] Source:PLoS One;11(11):e0167040, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The onslaught on the World's wildlife continues despite numerous initiatives aimed at curbing it. We build a model that integrates rhino horn trade with rhino population dynamics in order to evaluate the impact of various management policies on rhino sustainability. In our model, an agent-based sub-model of horn trade from the poaching event up through a purchase of rhino horn in Asia impacts rhino abundance. A data-validated, individual-based sub-model of the rhino population of South Africa provides these abundance values. We evaluate policies that consist of different combinations of legal trade initiatives, demand reduction marketing campaigns, increased anti-poaching measures within protected areas, and transnational policing initiatives aimed at disrupting those criminal syndicates engaged in horn trafficking. Simulation runs of our model over the next 35 years produces a sustainable rhino population under only one management policy. This policy includes both a transnational policing effort aimed at dismantling those criminal networks engaged in rhino horn trafficking-coupled with increases in legal economic opportunities for people living next to protected areas where rhinos live. This multi-faceted approach should be the focus of the international debate on strategies to combat the current slaughter of rhino rather than the binary debate about whether rhino horn trade should be legalized. This approach to the evaluation of wildlife management policies may be useful to apply to other species threatened by wildlife trafficking.
[Mh] Termos MeSH primário: Crime/economia
Crime/prevenção & controle
Espécies em Perigo de Extinção/economia
Cornos
Modelos Econômicos
[Mh] Termos MeSH secundário: Animais
África do Sul
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170623
[Lr] Data última revisão:
170623
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161122
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0167040


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[PMID]:27760516
[Au] Autor:Lühken G; Krebs S; Rothammer S; Küpper J; Mioc B; Russ I; Medugorac I
[Ad] Endereço:Department of Animal Breeding and Genetics, Justus Liebig University of Gießen, Ludwigstrasse 21a, 35390, Giessen, Germany.
[Ti] Título:The 1.78-kb insertion in the 3'-untranslated region of RXFP2 does not segregate with horn status in sheep breeds with variable horn status.
[So] Source:Genet Sel Evol;48(1):78, 2016 10 19.
[Is] ISSN:1297-9686
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The mode of inheritance of horn status in sheep is far more complex than a superficial analysis might suggest. Observations, which were mostly based on crossbreeding experiments, indicated that the allele that results in horns is dominant in males and recessive in females, and some authors even speculated about the involvement of more than two alleles. However, all recent genome-wide association analyses point towards a very strong effect of a single autosomal locus on ovine chromosome 10, which was narrowed down to a putatively causal insertion polymorphism in the 3'-untranslated region of the relaxin/insulin-like family peptide receptor 2 gene (RXFP2). The main objective of this study was to test this insertion polymorphism as the causal mutation in diverse sheep breeds, including breeds with a variable and/or sex-dependent horn status. RESULTS: After re-sequencing a region of about 246 kb that covered the RFXP2 gene and its flanking regions for 24 sheep from six completely horned and six completely polled breeds, we identified the same insertion polymorphism that was previously published as segregating with horn status in these breeds. Multiplex PCR genotyping of 489 sheep from 34 breeds and some crosses between sheep breeds showed a nearly perfect segregation of the insertion polymorphism with horn status in sheep breeds of Central and Western European origin. In these breeds and their crossings, heterozygous males were horned and heterozygous females were polled. However, this segregation pattern was not, or at least not completely, reproducible in breeds with sex-dependent and/or variable horn status, especially in sheep that originated from even more southern European regions and from Africa. In such breeds, we observed almost all possible combinations of genotype, sex and horn status phenotype. CONCLUSIONS: The 1.78-kb insertion polymorphism in the 3'-untranslated region of RXFP2 and SNPs in the 3'-UTR, exon 14 and intron 11 of this gene that we analyzed in this study cannot be considered as the only cause of polledness in sheep and are not useful as a universal marker to define the genetic horn status in sheep.
[Mh] Termos MeSH primário: Receptores Acoplados a Proteínas-G/genética
Carneiro Doméstico/genética
[Mh] Termos MeSH secundário: Regiões 3' não Traduzidas
Alelos
Animais
Mapeamento Cromossômico/métodos
Feminino
Estudos de Associação Genética
Estudo de Associação Genômica Ampla
Cornos/crescimento & desenvolvimento
Masculino
Mutagênese Insercional
Mutação
Polimorfismo de Nucleotídeo Único
Seleção Artificial/genética
Fatores Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (3' Untranslated Regions); 0 (Receptors, G-Protein-Coupled)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161021
[St] Status:MEDLINE


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[PMID]:27665137
[Au] Autor:Winder CB; LeBlanc SJ; Haley DB; Lissemore KD; Godkin MA; Duffield TF
[Ad] Endereço:Department of Population Medicine, University of Guelph, Ontario, Canada N1G 2W1.
[Ti] Título:Practices for the disbudding and dehorning of dairy calves by veterinarians and dairy producers in Ontario, Canada.
[So] Source:J Dairy Sci;99(12):10161-10173, 2016 Dec.
[Is] ISSN:1525-3198
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Disbudding and dehorning dairy calves is very common, despite the introduction of polled genetics to most dairy breeds. Appropriate pain-control practices for these procedures affect both calf welfare and public perception of the dairy industry. Previously published work has shown that North American dairy producers have not widely adopted use of these medications for disbudding or dehorning. However, since the last published work examining these practices in Canada, changes regarding awareness, availability, and future requirements for pain control have occurred in the industry. With this in mind, online and telephone surveys of both veterinarians (n=238) and dairy producers (n=603) in Ontario, Canada, were conducted in the fall of 2014 with a goal of describing current disbudding and dehorning practices and examining factors associated with the adoption of pain control use. Approximately three-quarters of dairy producers reported performing disbudding or dehorning themselves, whereas the remainder used a veterinarian or technician. Almost all (97%) of the veterinarians surveyed reported using local anesthetic, 62% used sedation, and 48% used a nonsteroidal anti-inflammatory drug. Producer use of local anesthetic was 62%, 38% used sedation and 24% used a nonsteroidal anti-inflammatory drug. Seventy-eight percent of veterinarian disbudding or dehorning was done before 8wk of age, whereas 64% of dairy producers performed this procedure before 8wk of age. Seventy-two percent of veterinarians and 63% of producers reported changing their disbudding or dehorning practices over the past 10 yr; of producers that changed their practices, 73% cited their herd veterinarian as influential. The use of pain control described in these surveys is higher than previously reported in Ontario. Identification of factors associated with best practices, or the lack of adoption of these practices, may help veterinarians target appropriate educational opportunities for their dairy clients.
[Mh] Termos MeSH primário: Cornos/cirurgia
Manejo da Dor/veterinária
[Mh] Termos MeSH secundário: Anestesia Local/veterinária
Animais
Bovinos
Indústria de Laticínios
Ontário
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160926
[St] Status:MEDLINE


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[PMID]:27648948
[Au] Autor:McCarthy D; Windsor PA; Harris C; Lomax S; White PJ
[Ad] Endereço:School of Life and Environmental Sciences, Faculty of Veterinary Science, University of Sydney, Sydney, NSW, Australia.
[Ti] Título:Effect of Topically Applied Anaesthetic Formulation on the Sensitivity of Scoop Dehorning Wounds in Calves.
[So] Source:PLoS One;11(9):e0163181, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The post-operative effects of three formulations of topical anaesthetic and a cornual nerve block on the sensitivity of scoop dehorning wounds in calves were compared in two trials. In Trial 1, 21 female Holstein dairy calves aged 8 to 24 weeks were randomly allocated to two groups: (1) scoop dehorning with a post-operative application of a novel topical anaesthetic powder (DTAP, n = 10); and (2) scoop dehorning with a post-operative application of a novel topical anaesthetic ethanol liquid (DTAE, n = 11). In Trial 2, 18 castrated male and 18 female Hereford beef calves aged 16 to 20 weeks were randomly allocated to four groups: (1) scoop dehorning with a pre-operative cornual nerve block of lignocaine (DCB, n = 9); (2) scoop dehorning with a post-operative application of the novel topical anaesthetic ethanol liquid from Trial 1 (DTAE, n = 9); (3) scoop dehorning with a post-operative application of a topical anaesthetic gel (DTAG, n = 9); and (4) sham dehorning (CON, n = 9). Sensitivity was assessed by scoring the behavioural response of calves to stimulation of the wound or skin at time points before and after treatment. In Trial 1, DTAP calves had a greater probability of displaying more severe responses than DTAE calves at 90 and 180 min (P < 0.001). In Trial 2, at 1 h, DTAG calves had a greater probability of displaying more severe responses than CON calves. At 2 h onwards, all dehorned calves had a greater probability of displaying more severe responses than CON calves (P < 0.001). There were no differences between the responses of DCB, DTAG and DTAE calves at any time point. Topical anaesthetic formulations result in almost immediate but temporary anaesthesia of the wound following scoop dehorning in calves and may provide a practical option for pain relief on-farm.
[Mh] Termos MeSH primário: Anestésicos Locais/uso terapêutico
Criação de Animais Domésticos/métodos
Etanol/uso terapêutico
Cornos/cirurgia
Dor Pós-Operatória/veterinária
[Mh] Termos MeSH secundário: Administração Tópica
Anestésicos Locais/administração & dosagem
Animais
Bovinos
Etanol/administração & dosagem
Feminino
Lidocaína/uso terapêutico
Masculino
Bloqueio Nervoso
Manejo da Dor
Dor Pós-Operatória/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Local); 3K9958V90M (Ethanol); 98PI200987 (Lidocaine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170804
[Lr] Data última revisão:
170804
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160921
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0163181


  10 / 619 MEDLINE  
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[PMID]:27581556
[Au] Autor:Kakkar P; Balaraman M; Shanmugam G
[Ad] Endereço:Central Leather Research Institute-Council for Scientific and Industrial Research, Adyar, Chennai-600020, India.
[Ti] Título:Transient structures of keratins from hoof and horn influence their self association and supramolecular assemblies.
[So] Source:Int J Biol Macromol;93(Pt A):172-178, 2016 Dec.
[Is] ISSN:1879-0003
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Keratins as fibrous proteins, offer structural integrity to various tissues in providing the functional role of protection or load bearing. This work is a prelude to understand the structure - property correlation for a wide variety of keratins. The kinetics of aggregation of bovine hoof keratin (KF) and horn keratin (KR) were monitored by different biophysical methods. pH dependent studies indicated that initially both keratins existed in pre-aggregated form and the efficiency of aggregation decreased with increasing pH. The size of the aggregates was found to be larger in KF compared to KR. UV-vis and particle size analysis clearly revealed that the pre-aggregated forms of KF and KR dissociated to intermediate transient structures with smaller aggregate size, which acted as stronger nucleating agents for further self association of the keratins to form higher order supramolecular assemblies. Conformational analysis indicated that there was no significant conformational change during the aggregation of KF and KR. Morphology of the KF aggregates showed fractal arrangement while KR aggregates formed an ordered structure with no particular arrangement. To the best of our knowledge, this is the first report which shows an interesting and unique observation on changes in the structure during self-association of keratins.
[Mh] Termos MeSH primário: Casco e Garras
Cornos
Queratinas/química
Agregados Proteicos
[Mh] Termos MeSH secundário: Animais
Bovinos
Concentração de Íons de Hidrogênio
Queratinas/metabolismo
Cinética
Tamanho da Partícula
Estrutura Secundária de Proteína
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Protein Aggregates); 68238-35-7 (Keratins)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170404
[Lr] Data última revisão:
170404
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160902
[St] Status:MEDLINE



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