Base de dados : MEDLINE
Pesquisa : A13.507.288 [Categoria DeCS]
Referências encontradas : 544 [refinar]
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[PMID]:29254926
[Au] Autor:Hu PF; Xu JP; Ai C; Shao XJ; Wang HL; Dong YM; Cui XZ; Fuhe Y; Xiumei X
[Ad] Endereço:State Key Laboratory for Molecular Biology of Special Economic Animals, Key Laboratory of Special Economic Animal Genetics and Breeding, Ministry of Agriculture, Institute of Special Economic Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China.
[Ti] Título:Screening weight related genes of velvet antlers by whole genome re-sequencing.
[So] Source:Yi Chuan;39(11):1090-1101, 2017 Nov 20.
[Is] ISSN:0253-9772
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:The velvet antler is a special organ that has important biological significance for deer, and its growth is a complicated biological metabolism process. Growing evidence suggests that genetics factors play essential roles in the weight of velvet antlers. In this study, we investigated five sika deer (Cervus nippon) populations under the same feeding condition, and screened genetic variations in the 100 samples (including 50 heavy and 50 light velvet antler weight samples) by whole genome re-sequencing. The results showed that 94 genetic variations were related to the velvet antler weight, among which two single nucleotide polymorphism (SNP) sites were located on the exon regions of OAS2 and ALYREF/THOC4, respectively. Furthermore, ALYREF/THOC4 is highly expressed in the velvet antler. The biological functions of these genetic variations were highly related to the growth and development of deer velvet antlers. Collectively, we screened genes related to the velvet antler weight in sika deer populations by whole genome re-sequencing and identified 94 sites as candidate genetic variations related to the velvet antler weight. We hope that it will contribute to further mechanistic studies of velvet antler development and weight variations.
[Mh] Termos MeSH primário: Chifres de Veado
Cervos/genética
Tamanho do Órgão/genética
Sequenciamento Completo do Genoma
[Mh] Termos MeSH secundário: Animais
Chifres de Veado/crescimento & desenvolvimento
Variação Genética
Polimorfismo de Nucleotídeo Único
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE
[do] DOI:10.16288/j.yczz.17-116


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[PMID]:29185790
[Au] Autor:Yao B; Zhang M; Liu M; Wang Q; Liu M; Zhao Y
[Ad] Endereço:1 Chinese Medicine and Bioengineering Research and Development Center, Changchun University of Chinese Medicine , Changchun, China .
[Ti] Título:Sox9 Functions as a Master Regulator of Antler Growth by Controlling Multiple Cell Lineages.
[So] Source:DNA Cell Biol;37(1):15-22, 2018 Jan.
[Is] ISSN:1557-7430
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Deer antlers are amazing natural appendages that grow faster than any other known mammalian bone. Antler growth occurs at the tip and is initially cartilage, which is later replaced by bone tissue. However, little is known regarding the precise role of cooperation between cell lineages and functional genes in regulating antler growth, and molecular mechanisms responsible for rapid growth remain elusive. In this study, we use an RNA-Seq approach to elucidate the full spectrum of cell lineages, functional genes, and their cooperative interactions during antler growth. We identify Sox9 as a pivotal transcription factor during chondrogenesis and skeletal development expressed in the chondrocyte lineage from the multipotent mesenchymal precursor stage through most subsequent cell differentiation stages with a particularly strong activity in proliferating and prehypertrophic chondrocytes. Furthermore, we analyze the miRNA expression patterns at initial growth stage and rapid growth stage and identify several miRNAs that involve in regulating antler chondrogenesis and rapid growth. Among these miRNAs, miR-140 plays pivotal role during antler growth by targeting Sox9 and vice versa.
[Mh] Termos MeSH primário: Chifres de Veado/crescimento & desenvolvimento
Chifres de Veado/metabolismo
Fatores de Transcrição SOX9/metabolismo
[Mh] Termos MeSH secundário: Animais
Cartilagem/metabolismo
Diferenciação Celular/fisiologia
Linhagem da Célula
Proliferação Celular/fisiologia
Condrócitos/metabolismo
Condrogênese/fisiologia
Cervos/crescimento & desenvolvimento
Cervos/metabolismo
Regulação da Expressão Gênica/fisiologia
MicroRNAs/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MicroRNAs); 0 (SOX9 Transcription Factor)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1089/dna.2017.3885


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[PMID]:28436029
[Au] Autor:Zhang HL; Yang ZQ; Duan CC; Geng S; Wang K; Yu HF; Yue ZP; Guo B
[Ad] Endereço:College of Veterinary Medicine, Jilin University, Changchun, P. R. China.
[Ti] Título:WNT4 acts downstream of BMP2 to mediate the regulation of ATRA signaling on RUNX1 expression: Implications for terminal differentiation of antler chondrocytes.
[So] Source:J Cell Physiol;233(2):1129-1145, 2018 Feb.
[Is] ISSN:1097-4652
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Although ATRA is involved in regulating the proliferation and differentiation of chondrocytes, its underlying mechanism remains unknown. Here we showed that ATRA could stimulate the proliferation of antler chondrocytes and expression of COL X and MMP13 which were two well-known markers for hypertrophic chondrocytes. Silencing of CRABP2 prevented the induction of ATRA on chondrocyte terminal differentiation, while overexpression of CRABP2 exhibited the opposite effects. CYP26A1 and CYP26B1 weakened the sensitivity of antler chondrocytes to ATRA. Further analysis evidenced that ATRA might induce chondrocyte terminal differentiation and modulate the expression of BMP2, WNT4, and RUNX1 through RARα/RXRα. Knockdown of BMP2 enhanced the induction of ATRA on the expression of COL X and MMP13, whereas overexpression of BMP2 abrogated this effectiveness. WNT4 might mediate the effects of ATRA and BMP2 on chondrocyte terminal differentiation. Dysregulation of BMP2 impaired the regulation of ATRA on WNT4 expression. Administration of ATRA to antler chondrocytes transfected with RUNX1 siRNA failed to induce the differentiation. Conversely, rRUNX1 strengthened the stimulation of ATRA on the expression of COL X and MMP13. Simultaneously, RUNX1 was a downstream effector of BMP2 and WNT4 in chondrocyte terminal differentiation. Moreover, WNT4 might play an important role in the crosstalk between BMP2 and RUNX1. Attenuation of BMP2 or WNT4 enhanced the interaction between ATRA and RUNX1, while constitutive expression of BMP2 or WNT4 reversed the regulation of ATRA on RUNX1. Collectively, WNT4 may act downstream of BMP2 to mediate the effects of ATRA on the terminal differentiation of antler chondrocytes through targeting RUNX1.
[Mh] Termos MeSH primário: Chifres de Veado/efeitos dos fármacos
Proteína Morfogenética Óssea 2/metabolismo
Diferenciação Celular/efeitos dos fármacos
Condrócitos/efeitos dos fármacos
Condrogênese/efeitos dos fármacos
Subunidade alfa 2 de Fator de Ligação ao Core/metabolismo
Tretinoína/farmacologia
Via de Sinalização Wnt/efeitos dos fármacos
Proteína Wnt4/metabolismo
[Mh] Termos MeSH secundário: Animais
Chifres de Veado/citologia
Chifres de Veado/metabolismo
Proteína Morfogenética Óssea 2/genética
Proliferação Celular/efeitos dos fármacos
Células Cultivadas
Condrócitos/metabolismo
Colágeno Tipo X/genética
Colágeno Tipo X/metabolismo
Subunidade alfa 2 de Fator de Ligação ao Core/genética
Cervos
Regulação da Expressão Gênica
Metaloproteinase 13 da Matriz/genética
Metaloproteinase 13 da Matriz/metabolismo
Interferência de RNA
Receptores do Ácido Retinoico/agonistas
Receptores do Ácido Retinoico/genética
Receptores do Ácido Retinoico/metabolismo
Ácido Retinoico 4 Hidroxilase/genética
Ácido Retinoico 4 Hidroxilase/metabolismo
Fatores de Tempo
Transfecção
Proteína Wnt4/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bone Morphogenetic Protein 2); 0 (Collagen Type X); 0 (Core Binding Factor Alpha 2 Subunit); 0 (Receptors, Retinoic Acid); 0 (Wnt4 Protein); 5688UTC01R (Tretinoin); EC 1.14.14.1 (Retinoic Acid 4-Hydroxylase); EC 3.4.24.- (Matrix Metalloproteinase 13)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170425
[St] Status:MEDLINE
[do] DOI:10.1002/jcp.25972


  4 / 544 MEDLINE  
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[PMID]:28977014
[Au] Autor:Osipowicz G; Witas H; Lisowska-Gaczorek A; Reitsema L; Szostek K; Ploszaj T; Kuriga J; Makowiecki D; Jedrychowska-Danska K; Cienkosz-Stepanczak B
[Ad] Endereço:Institute of Archaeology, Nicolaus Copernicus University, Torun, Kuyavian-Pomeranian Voivodeship, Poland.
[Ti] Título:Origin of the ornamented bâton percé from the Golebiewo site 47 as a trigger of discussion on long-distance exchange among Early Mesolithic communities of Central Poland and Northern Europe.
[So] Source:PLoS One;12(10):e0184560, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This article describes evidence for contact and exchange among Mesolithic communities in Poland and Scandinavia, based on the interdisciplinary analysis of an ornamented bâton percé from Golebiewo site 47 (Central Poland). Typological and chronological-cultural analyses show the artefact to be most likely produced in the North European Plain, during the Boreal period. Carbon-14 dating confirms the antiquity of the artefact. Ancient DNA analysis shows the artefact to be of Rangifer tarandus antler. Following this species designation, a dispersion analysis of Early-Holocene reindeer remains in Europe was conducted, showing this species to exist only in northern Scandinavia and north-western Russia in this period. Therefore, the bâton from Golebiewo constitutes the youngest reindeer remains in the European Plain and south-western Scandinavia known to date. An attempt was made to determine the biogeographic region from which the antler used to produce the artefact originates from. To this end, comprehensive δ18O, δ13C and δ15N isotope analyses were performed. North Karelia and South Lapland were determined as the most probable regions in terms of isotopic data, results which correspond to the known distribution range of Rangifer tarandus at this time. In light of these finds, the likelihood of contact between Scandinavia and Central Europe in Early Holocene is evaluated. The bâton percé from Golebiewo is likely key evidence for long-distance exchange during the Boreal period.
[Mh] Termos MeSH primário: Migração Animal
Chifres de Veado
Fósseis
Rena
[Mh] Termos MeSH secundário: Animais
Artefatos
DNA/genética
Europa (Continente)
Seres Humanos
Paleontologia
Polônia
Polimorfismo de Nucleotídeo Único
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
9007-49-2 (DNA)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171005
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184560


  5 / 544 MEDLINE  
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[PMID]:28832242
[Au] Autor:Wang DT; Chu WH; Sun HM; Ba HX; Li CY
[Ad] Endereço:Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun, People's Republic of China.
[Ti] Título:Expression and Functional Analysis of Tumor-Related Factor S100A4 in Antler Stem Cells.
[So] Source:J Histochem Cytochem;65(10):579-591, 2017 Oct.
[Is] ISSN:1551-5044
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Annual antler renewal is a stem cell-based epimorphic process driven by antler stem cells (ASCs) resident in antlerogenic periosteum (AP). Antlerogenic periosteal cells express a high level of S100A4, a metastasis-associated protein, which intrigued us to explore what role S100A4 could play in antler regeneration. The present study set out to investigate expression and effects of S100A4 in the ASCs and their progeny. The results showed that not only did cells from the AP express a high level of S100A4, but also the pedicle periosteum and the antler growth center. In the antler growth center, we found S100A4-positive cells were specifically located in blood vessel walls and in vascularized areas. In vitro, recombinant deer S100A4 protein stimulated the proliferation of the AP cells, promoted proliferation, migration and tube formation of human vascular endothelial cells, and enhanced migration of Hela cells, but not AP cells. These findings demonstrated that S100A4 in the ASCs may play a significant role in stimulating angiogenesis, proliferation, but not motility, of ASCs. Deer antlers offer a unique model to explore how rapid cell proliferation with a high level of S100A4 expression is elegantly regulated without becoming cancerous.
[Mh] Termos MeSH primário: Chifres de Veado/citologia
Regulação da Expressão Gênica
Proteína A4 de Ligação a Cálcio da Família S100/genética
Proteína A4 de Ligação a Cálcio da Família S100/metabolismo
Células-Tronco/metabolismo
[Mh] Termos MeSH secundário: Animais
Chifres de Veado/crescimento & desenvolvimento
Chifres de Veado/fisiologia
Movimento Celular
Proliferação Celular
Cervos
Células HeLa
Seres Humanos
Masculino
Periósteo/metabolismo
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Regeneração
Células-Tronco/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Messenger); 0 (S100 Calcium-Binding Protein A4)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1369/0022155417727263


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[PMID]:28733032
[Au] Autor:Liu G; Ma C; Wang P; Zhang P; Qu X; Liu S; Zhai Z; Yu D; Gao J; Liang J; Dai W; Zhou L; Xia M; Yang H
[Ad] Endereço:Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; Department of Orthopaedics, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, The Affiliated XuZhou Hospital of Medical College of Southeast University, Xuzhou Clinica
[Ti] Título:Pilose antler peptide potentiates osteoblast differentiation and inhibits osteoclastogenesis via manipulating the NF-κB pathway.
[So] Source:Biochem Biophys Res Commun;491(2):388-395, 2017 Sep 16.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bones are inflexible yet ever-changing metabolic organs, and bone homeostasis is maintained through two delicately regulated processes: bone construction and bone reabsorption. An imbalance in bone metabolism is linked to most orthopedic diseases, including osteoporosis and rheumatoid arthritis. Importantly, tumor necrosis factor-α (TNF-α) blocks osteoblast differentiation and stimulates osteoclast formation, resulting in delayed deposition of new bone and accelerated bone resorption, especially in rheumatoid arthritis patients with inflammatory conditions. Pilose antler peptide (PAP) isolated and purified from deer antlers has been shown to have beneficial effects on chronic inflammation. In the present study, we studied the impact of PAP on osteoblast differentiation and evaluated the regulatory mechanism, with particular emphasis on the effect of PAP on TNF-α-mediated NF-κB signaling. Mouse primary osteoblast cells were activated with bone morphogenetic protein-2 (BMP-2) for osteoblast differentiation. A significant stimulatory effect of PAP in osteoblastogenesis was observed using ALP activity and Alizarin Red S staining assays. Meanwhile, PAP significantly rescued TNF-α-induced impairment of osteoblast formation as well as mineralization. Furthermore, we found a similar trend upon analyzing osteoblast-specific gene expression. PAP significantly rescued TNF-α-mediated decrease in expression of osteoblast-specific genes. A molecular mechanism assay indicated that PAP significantly inhibited TNF-α-mediated stimulation of NF-κB signaling activity, as well as nuclear translocation of its subunit p65. Moreover, over-expression of p65 reversed the stimulatory effects of PAP on osteoblast differentiation. Furthermore, we also identified that PAP dose dependently inhibit osteoclastogenesis, and this effect might be achieved via suppressing NF-κB activity. In summary, this study shows that PAP promotes osteoblast differentiation and blocks TNF-α-mediated suppression of osteoblastogenesis in vitro via the NF-κB/p65 pathway, as well as inhibits osteoclastsogenesis in vitro. Therefore, PAP, a novel drug with both antiresorptive and osteoanabolic activity, shows therapeutic potential as an alternative treatment for osteolytic diseases, including rheumatoid arthritis and osteoporosis.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/farmacologia
Chifres de Veado/química
Conservadores da Densidade Óssea/farmacologia
Peptídeos/farmacologia
[Mh] Termos MeSH secundário: Fosfatase Alcalina/genética
Fosfatase Alcalina/metabolismo
Animais
Antraquinonas
Anti-Inflamatórios não Esteroides/isolamento & purificação
Conservadores da Densidade Óssea/isolamento & purificação
Proteína Morfogenética Óssea 2/farmacologia
Reabsorção Óssea/prevenção & controle
Diferenciação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Cervos
Relação Dose-Resposta a Droga
Regulação da Expressão Gênica
Camundongos
Camundongos Endogâmicos C57BL
Osteoblastos/citologia
Osteoblastos/efeitos dos fármacos
Osteoblastos/metabolismo
Osteoclastos/citologia
Osteoclastos/efeitos dos fármacos
Osteogênese/efeitos dos fármacos
Osteogênese/genética
Peptídeos/isolamento & purificação
Cultura Primária de Células
Transdução de Sinais
Fator de Transcrição RelA/antagonistas & inibidores
Fator de Transcrição RelA/genética
Fator de Transcrição RelA/metabolismo
Fator de Necrose Tumoral alfa/antagonistas & inibidores
Fator de Necrose Tumoral alfa/genética
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthraquinones); 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Bmp2 protein, mouse); 0 (Bone Density Conservation Agents); 0 (Bone Morphogenetic Protein 2); 0 (Peptides); 0 (Rela protein, mouse); 0 (Transcription Factor RelA); 0 (Tumor Necrosis Factor-alpha); 3F3AT0Q12H (Alizarin Red S); EC 3.1.3.1 (Alkaline Phosphatase)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170723
[St] Status:MEDLINE


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[PMID]:28643469
[Au] Autor:Zhang HL; Guo B; Yang ZQ; Duan CC; Geng S; Wang K; Yu HF; Yue ZP
[Ad] Endereço:College of Veterinary Medicine, Jilin University, Changchun, P.R. China.
[Ti] Título:ATRA Signaling Regulates the Expression of COL9A1 through BMP2-WNT4-RUNX1 Pathway in Antler Chondrocytes.
[So] Source:J Exp Zool B Mol Dev Evol;328(6):575-586, 2017 Sep.
[Is] ISSN:1552-5015
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Although all-trans retinoic acid (ATRA) is involved in the regulation of cartilage growth and development, its regulatory mechanisms remain unknown. Here, we showed that ATRA could induce the expression of COL9A1 in antler chondrocytes. Silencing of cellular retinoic acid binding protein 2 (CRABP2) could impede the ATRA-induced upregulation of COL9A1, whereas overexpression of CRABP2 presented the opposite effect. RARα agonist Am80 induced the expression of COL9A1, whereas treatment with RARα antagonist Ro 41-5253 or RXRα small-interfering RNA (siRNA) caused an obvious blockage of ATRA on COL9A1. In antler chondrocytes, CYP26A1 and CYP26B1 weakened the sensitivity of ATRA to COL9A1. Simultaneously, Bone morphogenetic protein 2 (BMP2) and WNT4 mediated the regulation of ATRA on COL9A1 expression. Knockdown of WNT4 could abrogate the inhibitory effect of BMP2 overexpression on COL9A1. Conversely, constitutive expression of WNT4 reversed the upregulation of COL9A1 elicited by BMP2 siRNA. Together these data indicated that WNT4 might act downstream of BMP2 to mediate the effect of ATRA on COL9A1 expression. Further analysis evidenced that attenuation of runt-related transcription factor 1 (RUNX1) could prevent the stimulation of ATRA on COL9A1 expression, while exogenous rRUNX1 further enhanced this effectiveness. Moreover, RUNX1 might serve as an intermediate to mediate the regulation of BMP2 and WNT4 on COL9A1 expression. Collectively, ATRA signaling might regulate the expression of COL9A1 through BMP2-WNT4-RUNX1 pathway.
[Mh] Termos MeSH primário: Chifres de Veado/citologia
Proteína Morfogenética Óssea 2/metabolismo
Colágeno Tipo IX/metabolismo
Regulação da Expressão Gênica/fisiologia
Transdução de Sinais/fisiologia
Tretinoína/metabolismo
[Mh] Termos MeSH secundário: Animais
Proteína Morfogenética Óssea 2/genética
Condrócitos/efeitos dos fármacos
Condrócitos/metabolismo
Colágeno Tipo IX/genética
Subunidade alfa 2 de Fator de Ligação ao Core/genética
Subunidade alfa 2 de Fator de Ligação ao Core/metabolismo
Proteína Wnt4/genética
Proteína Wnt4/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bone Morphogenetic Protein 2); 0 (Collagen Type IX); 0 (Core Binding Factor Alpha 2 Subunit); 0 (Wnt4 Protein); 5688UTC01R (Tretinoin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170624
[St] Status:MEDLINE
[do] DOI:10.1002/jez.b.22756


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[PMID]:28410135
[Au] Autor:Chu W; Zhao H; Li J; Li C
[Ad] Endereço:Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, State Key Lab for Molecular Science of Special AnimalsChangchun, Beijing, China.
[Ti] Título:Custom-built tools for the study of deer antler biology.
[So] Source:Front Biosci (Landmark Ed);22:1622-1633, 2017 Jun 01.
[Is] ISSN:1093-4715
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Deer antlers can be developed into multiple novel models to study growth and development of tissues for biomedical research. To facilitate this process, we have invented and further refined five custom-built tools through three decades of antler research. These are: 1. Pedicle growth detector to pinpoint the timing when pedicle growth is initiated, thus stimuli for pedicle and first antler formation can be investigated and identified. 2. Thin periosteum slice cutter to thinly slice (0.2mm or 0.7 mm thick) a whole piece of antlerogenic periosteum (AP) or pedicle periosteum (PP), which facilitates gene delivery into cells resident in these tissues, thus making transgenic antlers possible. 3. The porous periosteum multi-needle punch to effectively loosen the dense AP or PP tissue. This allows most cells of the periosteum to come into direct contact with treating solutions, thus making artificial manipulation of antler development possible. 4. The intra-dermal pocket maker to cut the thin dermal tissue (less than 2 mm in thickness) of a male deer calf horizontally into two layers to make an intra-dermal pocket. This allows loading of AP tissue intra-dermally to test the theory of "antler stem cell niche" . 5. The sterile periosteum sampling system to allow aseptic collection of the AP, PP or the antler growth centre tissue on farm, thus allowing antler generation, regeneration or rapid growth to be investigated . Overall, we believe the application of contemporary cellular and molecular biological techniques coupled with these custom-built tools would greatly promote the establishment of this unique and novel model for the benefits of biomedical research, and hence human health.
[Mh] Termos MeSH primário: Chifres de Veado/fisiologia
Cervos/fisiologia
Periósteo/fisiologia
Regeneração
Manejo de Espécimes/instrumentação
Manejo de Espécimes/métodos
[Mh] Termos MeSH secundário: Animais
Chifres de Veado/anatomia & histologia
Cervos/anatomia & histologia
Dissecação/instrumentação
Dissecação/métodos
Masculino
Microtomia/instrumentação
Microtomia/métodos
Modelos Animais
Periósteo/anatomia & histologia
Medicina Regenerativa/instrumentação
Medicina Regenerativa/métodos
Medicina Regenerativa/tendências
Pesquisa/tendências
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE


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[PMID]:28324255
[Au] Autor:Gizejewska A; Szkoda J; Nawrocka A; Zmudzki J; Gizejewski Z
[Ad] Endereço:Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 14, 10-719, Olsztyn, Poland.
[Ti] Título:Can red deer antlers be used as an indicator of environmental and edible tissues' trace element contamination?
[So] Source:Environ Sci Pollut Res Int;24(12):11630-11638, 2017 Apr.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Venison is an attractive product for consumers concerned with healthy lifestyle; however, it can contain high levels of toxic elements, and therefore, it is a possible source of hazardous contaminants in human diet. Antlers are suitable bioindicators of environmental metal contamination, and herein, we assessed the ability of trace element levels in antlers to indicate levels in edible soft tissues. We determined the concentrations of lead (Pb), cadmium (Cd), mercury (Hg), arsenic (As), copper (Cu), zinc (Zn), and iron (Fe) in the liver, kidney, muscle, and antlers of 14 free-ranging red deer (Cervus elaphus) from northeastern Poland using atomic absorption spectrometry. We found the highest concentrations of Pb (0.321 ± 0.165 mg/kg), As (0.045 ± 0.074 mg/kg), Zn (105.31 ± 16.33 mg/kg), and Fe (220.92 ± 117.18 mg/kg) in antlers; of Cd (4.974 ± 1.90 mg/kg) and Hg (0.048 ± 0.102 mg/kg) in kidney; and of Cu (7.29 ± 7.02 mg/kg) in the liver. A positive relationship between concentrations in antlers and muscle was found only for Cu (p = 0.001), and it therefore appears that red deer antlers cannot be used as an index for element concentrations in soft tissues. While our results confirm that the Mazury region is little polluted, consumption of red deer offal from this area should be limited according to extant legal limits set for livestock consumption.
[Mh] Termos MeSH primário: Chifres de Veado/química
Monitoramento Ambiental/métodos
Poluentes Ambientais/análise
Metais Pesados/análise
Oligoelementos/análise
[Mh] Termos MeSH secundário: Animais
Cervos
Contaminação de Alimentos
Seres Humanos
Polônia
Carne Vermelha
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Environmental Pollutants); 0 (Metals, Heavy); 0 (Trace Elements)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-017-8798-7


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[PMID]:28296944
[Au] Autor:Kierdorf U; Miller KV; Flohr S; Gomez S; Kierdorf H
[Ad] Endereço:Department of Biology, University of Hildesheim, Hildesheim, Germany.
[Ti] Título:Multiple osteochondromas of the antlers and cranium in a free-ranging white-tailed deer (Odocoileus virginianus).
[So] Source:PLoS One;12(3):e0173775, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This paper reports a case of multiple osteochondromas affecting the antlers and the left zygomatic bone of a free-ranging adult white-tailed buck (Odocoileus virginianus) from Georgia, USA. Along with a few postcranial bones, the antlered cranium of the individual was found in a severely weathered condition and devoid of any soft tissue. The antlers exhibited five pedunculated exostoses that were composed of cancellous bone and, in their peripheral portions, also mineralized cartilage. The largest of the exostoses, located on the right antler, had a maximum circumference of 55 cm. The exostosis arising from the zygomatic bone was broad-based and much smaller than the exophytic outgrowths on the antlers. Diagnosis of the exostoses as osteochondromas was based on their overall morphology, the normal bone structure in their stalk regions, and the continuity of their spongiosa and cortex with the respective components of the parent bones. Antleromas, i.e., pathological outgrowths developing on antlers as a result of insufficient androgen production, were excluded in the differential diagnosis, based on (1) the apparent maturity and, except for the tumors, normal shape of the antlers and (2) the fact that exostosis formation had also affected the zygomatic bone. Previously only a single case of solitary osteochondroma of an antler has been described in the scientific literature. The case presented here is the first report of multiple osteochondromas in a deer. As antlers are regularly collected as trophies, and huge numbers of them are critically inspected each year, the fact that thus far only two cases of antler osteochondromas have been reported suggests that these tumors are very rare.
[Mh] Termos MeSH primário: Chifres de Veado/patologia
Neoplasias Ósseas/veterinária
Osteocondroma/veterinária
Crânio/patologia
[Mh] Termos MeSH secundário: Animais
Neoplasias Ósseas/diagnóstico
Neoplasias Ósseas/patologia
Cervos
Osteocondroma/diagnóstico
Osteocondroma/patologia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0173775



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