Base de dados : MEDLINE
Pesquisa : A13.895 [Categoria DeCS]
Referências encontradas : 6403 [refinar]
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  1 / 6403 MEDLINE  
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[PMID]:29338262
[Au] Autor:Ashigai H; Taniguchi Y; Matsukura Y; Ikeshima E; Nakashima K; Mizutani M; Yajima H
[Ad] Endereço:Research Laboratories for Health Science & Food Technologies, Kirin Co., Ltd. , 1-17-5 Namamugi, Tsurumi-ku, Yokohama 230-8628, Japan.
[Ti] Título:Roasted Barley Extract Affects Blood Flow in the Rat Tail and Increases Cutaneous Blood Flow and Skin Temperature in Humans.
[So] Source:J Agric Food Chem;66(5):1251-1257, 2018 Feb 07.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Roasted barley extract (RBE, "Mugicha") is a traditional Japanese beverage reported to improve blood viscosity and affect food functionality. RBE is suggested to contain 2,5-diketopiperazines, which are the functional component with neuroprotective and immunostimulatory effects that are produced in food through roasting. In this study, we investigated the effects of RBE on blood circulation, both clinically and in rats. At first, we confirmed five 2,5-diketopiperazine derivatives in RBE by LC-MS analysis. Secondarily, we revealed that RBE affects blood flow in the rat tail and compared the efficacy on rat tail blood flow among five 2,5-diketopiperazines in RBE. Especially, cyclo(d-Phe-l-Pro) was the most effective in increasing blood flow in the rat tail. We also researched the mechanism of cyclo(d-Phe-l-Pro) with rat aorta study. As a result, we confirmed that cyclo(d-Phe-l-Pro) has an effect on vasodilatation through the release of nitric oxide in the vascular endothelium. Finally, we also confirmed that RBE affects cutaneous blood flow and increases skin temperature in humans.
[Mh] Termos MeSH primário: Hordeum/química
Temperatura Alta
Extratos Vegetais/farmacologia
Temperatura Cutânea/efeitos dos fármacos
Pele/irrigação sanguínea
Cauda/irrigação sanguínea
[Mh] Termos MeSH secundário: Adulto
Animais
Velocidade do Fluxo Sanguíneo/efeitos dos fármacos
Dicetopiperazinas/análise
Dicetopiperazinas/farmacologia
Método Duplo-Cego
Feminino
Manipulação de Alimentos/métodos
Seres Humanos
Japão
Fluxometria por Laser-Doppler
Masculino
Placebos
Ratos
Ratos Wistar
Organismos Livres de Patógenos Específicos
Vasodilatação/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Diketopiperazines); 0 (Placebos); 0 (Plant Extracts); 240L69DTV7 (2,5-dioxopiperazine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04930


  2 / 6403 MEDLINE  
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[PMID]:28463470
[Au] Autor:Andrews RM; Skewes SA
[Ad] Endereço:Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia.
[Ti] Título:Developmental origin of limb size variation in lizards.
[So] Source:Evol Dev;19(3):136-146, 2017 05.
[Is] ISSN:1525-142X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In many respects, reptile hatchlings are fully functional, albeit miniature, adults. This means that the adult morphology must emerge during embryonic development. This insight emphasizes the connection between the mechanisms that generate phenotypic variation during embryonic development and the action of selection on post-hatching individuals. To determine when species-specific differences in limb and tail lengths emerge during embryonic development, we compared allometric patterns of early limb growth of four distantly related species of lizards. The major questions addressed were whether early embryonic limb and tail growth is characterized by the gradual (continuous allometry) or by the abrupt emergence (transpositional allometry) of size differences among species. Our observations supported transpositional allometry of both limbs and tails. Species-specific differences in limb and tail length were exhibited when limb and tail buds first protruded from the body wall. Genes known to be associated with early limb development of tetrapods are obvious targets for studies on the genetic mechanisms that determine interspecific differences in relative limb length. Broadly comparative studies of gene regulation would facilitate understanding of the mechanisms underlying adaptive variation in limb size, including limb reduction and loss, of squamate reptiles.
[Mh] Termos MeSH primário: Extremidades/crescimento & desenvolvimento
Lagartos/crescimento & desenvolvimento
Lagartos/genética
[Mh] Termos MeSH secundário: Animais
Embrião não Mamífero/anatomia & histologia
Extremidades/anatomia & histologia
Feminino
Cabeça/anatomia & histologia
Lagartos/anatomia & histologia
Masculino
Cauda/anatomia & histologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1111/ede.12221


  3 / 6403 MEDLINE  
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[PMID]:29173119
[Au] Autor:Krajnak K; Miller GR; Waugh S
[Ad] Endereço:a Engineering and Controls Technology Branch , National Institute for Occupational Safety and Health Morgantown , Morgantown , WV , USA.
[Ti] Título:Contact area affects frequency-dependent responses to vibration in the peripheral vascular and sensorineural systems.
[So] Source:J Toxicol Environ Health A;81(1-3):6-19, 2018.
[Is] ISSN:1528-7394
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Repetitive exposure to hand-transmitted vibration is associated with development of peripheral vascular and sensorineural dysfunctions. These disorders and symptoms associated with it are referred to as hand-arm vibration syndrome (HAVS). Although the symptoms of the disorder have been well characterized, the etiology and contribution of various exposure factors to development of the dysfunctions are not well understood. Previous studies performed using a rat-tail model of vibration demonstrated that vascular and peripheral nervous system adverse effects of vibration are frequency-dependent, with vibration frequencies at or near the resonant frequency producing the most severe injury. However, in these investigations, the amplitude of the exposed tissue was greater than amplitude typically noted in human fingers. To determine how contact with vibrating source and amplitude of the biodynamic response of the tissue affects the risk of injury occurring, this study compared the influence of frequency using different levels of restraint to assess how maintaining contact of the tail with vibrating source affects the transmission of vibration. Data demonstrated that for the most part, increasing the contact of the tail with the platform by restraining it with additional straps resulted in an enhancement in transmission of vibration signal and elevation in factors associated with vascular and peripheral nerve injury. In addition, there were also frequency-dependent effects, with exposure at 250 Hz generating greater effects than vibration at 62.5 Hz. These observations are consistent with studies in humans demonstrating that greater contact and exposure to frequencies near the resonant frequency pose the highest risk for generating peripheral vascular and sensorineural dysfunction.
[Mh] Termos MeSH primário: Nervos Periféricos/fisiopatologia
Cauda/inervação
Vibração/efeitos adversos
[Mh] Termos MeSH secundário: Animais
Antioxidantes/análise
Modelos Animais de Doenças
Ensaio de Imunoadsorção Enzimática
Expressão Gênica
Síndrome da Vibração do Segmento Mão-Braço/etiologia
Síndrome da Vibração do Segmento Mão-Braço/fisiopatologia
Masculino
National Institute for Occupational Safety and Health (U.S.)
Exposição Ocupacional/efeitos adversos
Distribuição Aleatória
Ratos
Ratos Sprague-Dawley
Reação em Cadeia da Polimerase em Tempo Real
Cauda/enzimologia
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171215
[Lr] Data última revisão:
171215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1080/15287394.2017.1401022


  4 / 6403 MEDLINE  
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[PMID]:28743003
[Au] Autor:Das D; Chatti V; Emonet T; Holley SA
[Ad] Endereço:Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA.
[Ti] Título:Patterned Disordered Cell Motion Ensures Vertebral Column Symmetry.
[So] Source:Dev Cell;42(2):170-180.e5, 2017 07 24.
[Is] ISSN:1878-1551
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The biomechanics of posterior embryonic growth must be dynamically regulated to ensure bilateral symmetry of the spinal column. Throughout vertebrate trunk elongation, motile mesodermal progenitors undergo an order-to-disorder transition via an epithelial-to-mesenchymal transition and sort symmetrically into the left and right paraxial mesoderm. We combine theoretical modeling of cell migration in a tail-bud-like geometry with experimental data analysis to assess the importance of ordered and disordered cell motion. We find that increasing order in cell motion causes a phase transition from symmetric to asymmetric body elongation. In silico and in vivo, overly ordered cell motion converts normal anisotropic fluxes into stable vortices near the posterior tail bud, contributing to asymmetric cell sorting. Thus, disorder is a physical mechanism that ensures the bilateral symmetry of the spinal column. These physical properties of the tissue connect across scales such that patterned disorder at the cellular level leads to the emergence of organism-level order.
[Mh] Termos MeSH primário: Padronização Corporal
Movimento Celular
Coluna Vertebral/citologia
Coluna Vertebral/embriologia
Peixe-Zebra/embriologia
[Mh] Termos MeSH secundário: Animais
Simulação por Computador
Modelos Biológicos
Cauda/embriologia
Proteínas de Peixe-Zebra/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Zebrafish Proteins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171208
[Lr] Data última revisão:
171208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE


  5 / 6403 MEDLINE  
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[PMID]:28935526
[Au] Autor:Akahoshi T; Hotta K; Oka K
[Ad] Endereço:Department of Bioscience and Informatics, Faculty of Science and Technology, Keio University, Yokohama 223-8522, Japan.
[Ti] Título:Characterization of calcium transients during early embryogenesis in ascidians Ciona robusta (Ciona intestinalis type A) and Ciona savignyi.
[So] Source:Dev Biol;431(2):205-214, 2017 11 15.
[Is] ISSN:1095-564X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The calcium ion (Ca ) is an important second messenger, and a rapid increase in Ca level (Ca transient) is involved in various aspects of embryogenesis. Although Ca transients play an important role in early developmental stages, little is known about their dynamics throughout embryogenesis. Here, Ca transients were characterized by visualizing Ca dynamics in developing chordate embryos using a fluorescent protein-based Ca indicator, GCaMP6s in combination with finely tuned microscopy. Ca transients were detected in precursors of muscle cells in the late gastrula stage. In the neurula stage, repetitive Ca transients were observed in left and right neurogenic cells, including visceral ganglion (VG) precursors, and the duration of Ca transients was 39±4s. In the early tailbud stage, Ca transients were observed in differentiating precursors of nerve cord neurons. A small population of VG precursors showed rhythmical Ca transients with a duration of 22±4s, suggesting a central pattern generator (CPG) origin. At the mid tailbud stage, Ca transients were observed in a wide area of epidermal cells and named CTECs. The number and frequency of CTECs increased drastically in late tailbud stages, and the timing of the increase coincided with that of the relaxation of the tail bending. The experiment using Ca chelator showed that the CTECs were largely depending on the extracellular Ca . The waveform analysis of Ca transients revealed different features according to duration and frequency. The comprehensive characterization of Ca transients during early ascidian embryogenesis will help our understanding of the role of Ca signaling in chordate embryogenesis.
[Mh] Termos MeSH primário: Sinalização do Cálcio
Embrião não Mamífero/metabolismo
Desenvolvimento Embrionário
Urocordados/embriologia
Urocordados/metabolismo
[Mh] Termos MeSH secundário: Animais
Ciona intestinalis/embriologia
Ciona intestinalis/metabolismo
Gástrula/embriologia
Gástrula/metabolismo
Cauda/embriologia
Imagem com Lapso de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171111
[Lr] Data última revisão:
171111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170923
[St] Status:MEDLINE


  6 / 6403 MEDLINE  
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[PMID]:28851749
[Au] Autor:Dore R; Levata L; Gachkar S; Jöhren O; Mittag J; Lehnert H; Schulz C
[Ad] Endereço:Department of Internal Medicine ICenter of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany.
[Ti] Título:The thermogenic effect of nesfatin-1 requires recruitment of the melanocortin system.
[So] Source:J Endocrinol;235(2):111-122, 2017 Nov.
[Is] ISSN:1479-6805
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Nesfatin-1 is a bioactive polypeptide expressed both in the brain and peripheral tissues and involved in the control of energy balance by reducing food intake. Central administration of nesfatin-1 significantly increases energy expenditure, as demonstrated by a higher dry heat loss; yet, the mechanisms underlying the thermogenic effect of central nesfatin-1 remain unknown. Therefore, in this study, we sought to investigate whether the increase in energy expenditure induced by nesfatin-1 is mediated by the central melanocortin pathway, which was previously reported to mediate central nesfatin-1´s effects on feeding and numerous other physiological functions. With the application of direct calorimetry, we found that intracerebroventricular nesfatin-1 (25 pmol) treatment increased dry heat loss and that this effect was fully blocked by simultaneous administration of an equimolar dose of the melanocortin 3/4 receptor antagonist, SHU9119. Interestingly, the nesfatin-1-induced increase in dry heat loss was positively correlated with body weight loss. In addition, as assessed with thermal imaging, intracerebroventricular nesfatin-1 (100 pmol) increased interscapular brown adipose tissue (iBAT) as well as tail temperature, suggesting increased heat production in the iBAT and heat dissipation over the tail surface. Finally, nesfatin-1 upregulated pro-opiomelanocortin and melanocortin 3 receptor mRNA expression in the hypothalamus, accompanied by a significant increase in iodothyronine deiodinase 2 and by a nonsignificant increase in uncoupling protein 1 and peroxisome proliferator-activated receptor gamma coactivator-1 alpha mRNA in the iBAT. Overall, we clearly demonstrate that nesfatin-1 requires the activation of the central melanocortin system to increase iBAT thermogenesis and, in turn, overall energy expenditure.
[Mh] Termos MeSH primário: Proteínas de Ligação ao Cálcio/metabolismo
Proteínas de Ligação a DNA/metabolismo
Melanocortinas/metabolismo
Proteínas do Tecido Nervoso/metabolismo
Termogênese/fisiologia
[Mh] Termos MeSH secundário: Animais
Biomarcadores
Proteínas de Ligação ao Cálcio/genética
Proteínas de Ligação a DNA/genética
Orelha
Hipotálamo/metabolismo
Masculino
Hormônios Estimuladores de Melanócitos/farmacologia
Proteínas do Tecido Nervoso/genética
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Ratos
Ratos Wistar
Receptores de Melanocortina/antagonistas & inibidores
Receptores de Melanocortina/genética
Receptores de Melanocortina/metabolismo
Cauda
Proteína Desacopladora 1/genética
Proteína Desacopladora 1/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Calcium-Binding Proteins); 0 (DNA-Binding Proteins); 0 (Melanocortins); 0 (Nerve Tissue Proteins); 0 (RNA, Messenger); 0 (Receptors, Melanocortin); 0 (Ucp1 protein, rat); 0 (Uncoupling Protein 1); 0 (nucleobindin); 168482-23-3 (SHU 9119); 9002-79-3 (Melanocyte-Stimulating Hormones)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE
[do] DOI:10.1530/JOE-17-0151


  7 / 6403 MEDLINE  
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[PMID]:28705896
[Au] Autor:Sharma R; Shafer MER; Bareke E; Tremblay M; Majewski J; Bouchard M
[Ad] Endereço:Goodman Cancer Research Centre and Department of Biochemistry, McGill University, Montreal, Canada H3A 1A3.
[Ti] Título:Bmp signaling maintains a mesoderm progenitor cell state in the mouse tailbud.
[So] Source:Development;144(16):2982-2993, 2017 08 15.
[Is] ISSN:1477-9129
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Caudal somites are generated from a pool of progenitor cells located in the tailbud region. These progenitor cells form the presomitic mesoderm that gradually differentiates into somites under the action of the segmentation clock. The signals responsible for tailbud mesoderm progenitor pool maintenance during axial elongation are still elusive. Here, we show that Bmp signaling is sufficient to activate the entire mesoderm progenitor gene signature in primary cultures of caudal mesoderm cells. Bmp signaling acts through the key regulatory genes brachyury ( ) and and contributes to the activation of several other regulators of the mesoderm progenitor gene network. In the absence of Bmp signaling, tailbud mesoderm progenitor cells acquire aberrant gene expression signatures of the heart, blood, muscle and skeletal embryonic lineages. Treatment of embryos with the Bmp inhibitor noggin confirmed the requirement for Bmp signaling for normal expression and the prevention of abnormal lineage marker activation. Together, these results identify Bmp signaling as a non-cell-autonomous signal necessary for mesoderm progenitor cell homeostasis.
[Mh] Termos MeSH primário: Mesoderma/citologia
Mesoderma/embriologia
Células-Tronco/metabolismo
Cauda/citologia
Cauda/embriologia
[Mh] Termos MeSH secundário: Animais
Proteínas Morfogenéticas Ósseas/genética
Proteínas Morfogenéticas Ósseas/metabolismo
Citometria de Fluxo
Regulação da Expressão Gênica no Desenvolvimento/genética
Regulação da Expressão Gênica no Desenvolvimento/fisiologia
Proteínas de Homeodomínio/genética
Proteínas de Homeodomínio/metabolismo
Imuno-Histoquímica
Hibridização In Situ
Mesoderma/metabolismo
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Transgênicos
Proteínas Nucleares/genética
Proteínas Nucleares/metabolismo
Ratos
Reação em Cadeia da Polimerase em Tempo Real
Transdução de Sinais/genética
Transdução de Sinais/fisiologia
Células-Tronco/citologia
Cauda/metabolismo
Fatores de Transcrição/genética
Fatores de Transcrição/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bone Morphogenetic Proteins); 0 (Homeodomain Proteins); 0 (Nkx1-2 protein, mouse); 0 (Nuclear Proteins); 0 (Transcription Factors)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171126
[Lr] Data última revisão:
171126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE
[do] DOI:10.1242/dev.149955


  8 / 6403 MEDLINE  
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[PMID]:28686611
[Au] Autor:Lin AYT; Pearson BJ
[Ad] Endereço:Hospital for Sick Children, Program in Developmental and Stem Cell Biology, Toronto, ON, Canada.
[Ti] Título:Yorkie is required to restrict the injury responses in planarians.
[So] Source:PLoS Genet;13(7):e1006874, 2017 Jul.
[Is] ISSN:1553-7404
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Regeneration requires the precise integration of cues that initiate proliferation, direct differentiation, and ultimately re-pattern tissues to the proper size and scale. Yet how these processes are integrated with wounding responses remains relatively unknown. The freshwater planarian, Schmidtea mediterranea, is an ideal model to study the stereotyped proliferative and transcriptional responses to injury due to its high capacity for regeneration. Here, we characterize the effector of the Hippo signalling cascade, yorkie, during planarian regeneration and its role in restricting early injury responses. In yki(RNAi) regenerating animals, wound responses are hyper-activated such that both stem cell proliferation and the transcriptional wound response program are heighted and prolonged. Using this observation, we also uncovered novel wound-induced genes by RNAseq that were de-repressed in yki(RNAi) animals compared with controls. Additionally, we show that yki(RNAi) animals have expanded epidermal and muscle cell populations, which we hypothesize are the increased sources of wound-induced genes. Finally, we show that in yki(RNAi) animals, the sensing of the size of an injury by eyes or the pharynx is not appropriate, and the brain, gut, and midline cannot remodel or scale correctly to the size of the regenerating fragment. Taken together, our results suggest that yki functions as a key molecule that can integrate multiple aspects of the injury response including proliferation, apoptosis, injury-induced transcription, and patterning.
[Mh] Termos MeSH primário: Padronização Corporal/genética
Diferenciação Celular/genética
Proteínas Nucleares/genética
Regeneração/genética
[Mh] Termos MeSH secundário: Animais
Apoptose/genética
Proliferação Celular/genética
Olho/crescimento & desenvolvimento
Regulação da Expressão Gênica no Desenvolvimento
Proteínas Nucleares/biossíntese
Faringe/crescimento & desenvolvimento
Planárias/genética
Planárias/crescimento & desenvolvimento
Transdução de Sinais
Células-Tronco/metabolismo
Cauda/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nuclear Proteins)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pgen.1006874


  9 / 6403 MEDLINE  
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[PMID]:28677334
[Au] Autor:Xu SS; Ren X; Yang GL; Xie XL; Zhao YX; Zhang M; Shen ZQ; Ren YL; Gao L; Shen M; Kantanen J; Li MH
[Ad] Endereço:CAS Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences (CAS), Beijing, 100101, China.
[Ti] Título:Genome-wide association analysis identifies the genetic basis of fat deposition in the tails of sheep (Ovis aries).
[So] Source:Anim Genet;48(5):560-569, 2017 Oct.
[Is] ISSN:1365-2052
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Fat-tailed sheep (Ovis aries) can survive in harsh environments and satisfy human's intake of dietary fat. However, the animals require more feed, which increases the cost of farming. Thus, most farmers currently prefer thin-tailed, short-tailed or docked sheep. To date, the molecular mechanism of the formation of fat tails in sheep has not been completely elucidated. Here, we conducted a genome-wide association study using phenotypes and genotypes (the Ovine Infinium HD SNP BeadChip genotype data) of two breeds of contrasting tail types (78 Small-tailed and 78 Large-tailed Han sheep breeds) to identify functional genes and variants associated with fat deposition. We identified four significantly (rs416433540, rs409848439, rs408118325 and rs402128848) and three approximately associated autosomal SNPs (rs401248376, rs402445895 and rs416201901). Gene annotation indicated that the surrounding genes (CREB1, STEAP4, CTBP1 and RIP140, also known as NRIP1) function in lipid storage or fat cell regulation. Furthermore, through an X-chromosome-wide association analysis, we detected significantly associated SNPs in the OARX: 88-89 Mb region, which could be a strong candidate genomic region for fat deposition in tails of sheep. Our results represent a new genomic resource for sheep genetics and breeding. In addition, the findings provide novel insights into genetic mechanisms of fat deposition in the tail of sheep and other mammals.
[Mh] Termos MeSH primário: Adiposidade
Carneiro Doméstico/genética
Cauda/anatomia & histologia
[Mh] Termos MeSH secundário: Animais
Cruzamento
Mapeamento Cromossômico
Feminino
Estudos de Associação Genética
Genótipo
Masculino
Anotação de Sequência Molecular
Fenótipo
Polimorfismo de Nucleotídeo Único
Cromossomo X/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170706
[St] Status:MEDLINE
[do] DOI:10.1111/age.12572


  10 / 6403 MEDLINE  
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[PMID]:28612481
[Au] Autor:Alibardi L
[Ad] Endereço:Comparative Histolab and Department of Biology, University of Bologna, Bologna, Italy.
[Ti] Título:Review: Biological and Molecular Differences between Tail Regeneration and Limb Scarring in Lizard: An Inspiring Model Addressing Limb Regeneration in Amniotes.
[So] Source:J Exp Zool B Mol Dev Evol;328(6):493-514, 2017 Sep.
[Is] ISSN:1552-5015
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Tissue regeneration in lizards represents a unique model of regeneration and scarring in amniotes. The tail and limb contain putative stem cells but also dedifferentiating cells contribute to regeneration. Following tail amputation, inflammation is low and cell proliferation high, leading to regeneration while the intense inflammation in the limb leads to low proliferation and scarring. FGFs stimulate tail and limb regeneration and are present in the wound epidermis and blastema while they disappear in the limb wound epidermis 2-3 weeks postamputation in the scarring outgrowth. FGFs localize in the tail blastema and the apical epidermal peg (AEP), an epidermal microregion that allows tail growth but is absent in the limb. Inflammatory cells invade the limb blastema and wound epidermis, impeding the formation of an AEP. An embryonic program of growth is activated in the tail, dominated by Wnt-positive and -negative regulators of cell proliferation and noncoding RNAs, that represent the key regenerative genes. The balanced actions of these regulators likely impede the formation of a tumor in the tail tip. Genes for FACIT and fibrillar collagens, protease inhibitors, and embryonic keratins are upregulated in the regenerating tail blastema. A strong downregulation of genes for both B and T-lymphocyte activation suggests the regenerating tail blastema is a temporal immune-tolerated organ, whereas a scarring program is activated in the limb. Wnt inhibitors, pro-inflammatory genes, negative regulators of cell proliferation, downregulation of myogenic genes, proteases, and oxidases favoring scarring are upregulated. The evolution of an efficient immune system may be the main limiting barrier for organ regeneration in amniotes, and the poor regeneration of mammals and birds is associated with the efficiency of their mature immune system. This does not tolerate embryonic antigens formed in reprogrammed embryonic cells (as for neoplastic cells) that are consequently eliminated impeding the regeneration of lost organs.
[Mh] Termos MeSH primário: Cicatriz
Extremidades/fisiologia
Lagartos/fisiologia
Modelos Biológicos
Regeneração/fisiologia
Cauda/fisiologia
[Mh] Termos MeSH secundário: Animais
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.1002/jez.b.22754



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