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[PMID]:29278706
[Au] Autor:Azuma MM; Balani P; Boisvert H; Gil M; Egashira K; Yamaguchi T; Hasturk H; Duncan M; Kawai T; Movila A
[Ad] Endereço:The Forsyth Institute, Cambridge, MA, USA.
[Ti] Título:Endogenous acid ceramidase protects epithelial cells from Porphyromonas gingivalis-induced inflammation in vitro.
[So] Source:Biochem Biophys Res Commun;495(4):2383-2389, 2018 01 22.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ceramidases are a group of enzymes that degrade pro-inflammatory ceramide by cleaving a fatty acid to form anti-inflammatory sphingosine lipid. Thus far, acid, neutral and alkaline ceramidase isozymes have been described. However, the expression patterns of ceramidase isoforms as well as their role in periodontal disease pathogenesis remain unknown. In this study, expression patterns of ceramidase isoforms were quantified by real-time PCR and immunohistochemistry in gingival samples of patients with periodontitis and healthy subjects, as well as in EpiGingivalTM-3D culture and OBA-9 gingival epithelial cells both of which were stimulated with or without the presence of live Porphyromonas gingivalis (ATCC 33277 strain). A significantly lower level of acid ceramidase expression was detected in gingival tissues from periodontal patients compared to those from healthy subjects. In addition, acid-ceramidase expression in EpiGingival™ 3D culture and OBA-9 cells was suppressed by stimulation with P. gingivalis in vitro. No significant fluctuation was detected for neutral or alkaline ceramidases in either gingival samples or cell cultures. Next, to elucidate the role of acid ceramidase in P. gingivalis-induced inflammation in vitro, OBA-9 cells were transduced with adenoviral vector expressing the human acid ceramidase (Ad-ASAH1) gene or control adenoviral vector (Ad-control). In response to stimulation with P. gingivalis, ASAH1-over-expressing OBA-9 cells showed significantly lower mRNA expressions of caspase-3 as well as the percentage of Annexin V-positive cells, when compared with OBA-9 cells transduced with Ad-control vector. Furthermore, in response to stimulation with P. gingivalis, ASAH1-over-expressing OBA-9 cells produced less TNF-α, IL-6, and IL1ß pro-inflammatory cytokines than observed in OBA-9 cells transduced with Ad-control vector. Collectively, our data show the novel discovery of anti-inflammatory and anti-apoptotic effects of acid ceramidase in host cells exposed to periodontal bacteria, and the attenuation of the expression of host-protective acid ceramidase in periodontal lesions.
[Mh] Termos MeSH primário: Ceramidase Ácida/metabolismo
Infecções por Bacteroidaceae/enzimologia
Células Epiteliais/enzimologia
Células Epiteliais/microbiologia
Periodontite/enzimologia
Periodontite/microbiologia
Porphyromonas gingivalis/fisiologia
[Mh] Termos MeSH secundário: Ceramidase Ácida/química
Feminino
Seres Humanos
Masculino
Meia-Idade
Periodonto/enzimologia
Periodonto/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
EC 3.5.1.23 (Acid Ceramidase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171227
[St] Status:MEDLINE


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[PMID]:28791827
[Au] Autor:Górska R; Dembowska E; Konopka TP; Wysokinska-Miszczuk J; Pietruska M; Ganowicz E
[Ad] Endereço:Department of Periodontology and Oral Diseases, Medical University of Warsaw, Poland.
[Ti] Título:Correlation between the state of periodontal tissues and selected risk factors for periodontitis and myocardial infarction.
[So] Source:Adv Clin Exp Med;26(3):505-514, 2017 May-Jun.
[Is] ISSN:1899-5276
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The current level of knowledge indicates a relationship between periodontitis and diabetes and/or cardiovascular diseases (CVD). Periodontitis can be not only a risk factor for these diseases, but also a condition modifying other primary risk factors associated with the occurrence of cardiovascular complications (lipid disorders, arterial hypertension, etc.) or diabetes. OBJECTIVES: The aim of the study was an analysis of the correlation between the state of periodontal tissues and selected risk factors for myocardial infarction (MI) in patients after recent myocardial infarction. MATERIAL AND METHODS: The study included 417 patients (92 women, 325 men) hospitalized due to recent MI. The inclusion criteria were MI history and age below 70 years. The state of periodontal tissues (plaque index, bleeding on probing, pocket depth and clinical attachment loss, CPI index) and selected risk factors for periodontitis and CVD were recorded. RESULTS: An analysis of the results showed no statistically significant correlation between the depth, the number, percentage of periodontal pockets and the average clinical attachment level on one hand and BMI on the other hand. Whereas a statistically significant correlation was observed between tobacco smoking and the degree of severity of periodontal diseases measured by the average pocket depth, the number and percentage of pockets above 4 mm and the average clinical attachment loss, as well as between hypertension and the state of oral hygiene and between diabetes and the number of preserved teeth and the number of pockets above 4 mm. CONCLUSIONS: The degree of severity of periodontal disease can impact hypertension and diabetes, which could potentially influence the occurrence and course of CVD.
[Mh] Termos MeSH primário: Infarto do Miocárdio/etiologia
Infarto do Miocárdio/patologia
Periodontite/etiologia
Periodontite/patologia
Periodonto/patologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Hipertensão/etiologia
Hipertensão/patologia
Masculino
Meia-Idade
Fatores de Risco
Fumar/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170810
[St] Status:MEDLINE
[do] DOI:10.17219/acem/74652


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[PMID]:28675022
[Au] Autor:Xiaoguang L; Yizhu W; Bin G
[Ad] Endereço:Institution of Stomatology, The PLA General Hospital, Beijing 100853, China.
[Ti] Título:[Tumor necrosis factor-α regulates the osteogenic differentiation of bone marrow mesenchymal stem cells in chronic periodontitis].
[So] Source:Hua Xi Kou Qiang Yi Xue Za Zhi;35(3):334-338, 2017 Jun 01.
[Is] ISSN:1000-1182
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:Bone marrow mesenchymal stem cells (BMSCs) and ideal adult stem cells for alveolar bone regeneration considerably help restore the structure and function of the periodontium and promote the healing of periodontal disease. Thus, BMSC features, especially the mechanism of osteogenic differentiation, has recently become a research hotspot. Tumor necrosis factor-α (TNF-α), which is the main factor in the periodontal inflammatory microenvironment, is directly related to the osteogenic differentiation of BMSCs. Exploring the TNF-α-regulated differentiation mechanism of BMSCs aids in the search for new treatment targets. Such investigation also promotes the development of stem cell therapy for periodontal diseases. This article aims to describe the potential of TNF-α in regulating the osteogenic differentiation of stem cells.
[Mh] Termos MeSH primário: Periodontite Crônica
Osteogênese
Transplante de Células-Tronco
Fator de Necrose Tumoral alfa
[Mh] Termos MeSH secundário: Adulto
Células-Tronco Adultas
Células da Medula Óssea
Regeneração Óssea
Diferenciação Celular
Células-Tronco Hematopoéticas
Seres Humanos
Ligamento Periodontal
Periodonto
Cicatrização
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Tumor Necrosis Factor-alpha)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170705
[St] Status:MEDLINE
[do] DOI:10.7518/hxkq.2017.03.019


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[PMID]:28514340
[Au] Autor:Grudyanov AI; Tkacheva ON; Khatagov AT
[Ad] Endereço:Central Research Institute of Dentistry and Maxillofacial Surgery, Moscow, Russia.
[Ti] Título:[The impact of surgical and conservative treatment of periodontal disease on structural and functional condition of major blood vessels].
[Ti] Título:Vliianie khirurgicheskogo i konservativnogo lecheniia patsientov s bolezniami parodonta na strukturno-funktsional'noe sostoianie ikh magistral'nykh sosudov..
[So] Source:Stomatologiia (Mosk);96(2):12-16, 2017.
[Is] ISSN:0039-1735
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The study included 55 patients (24 men and 31 women aged 30-70 years) with chronic periodontal disease and atherosclerosis of brachiocephalic arteries (BCA). Patients in group 1 received only conservative treatment for periodontal disease, while in group 2 both conservative and surgical treatment were performed. The values were evaluated at baseline and 6 months after treatment. Capillaroscopy and laser Doppler flowmetry showed an improvement in periodontal regional vascular network. The level of IL-6 decreased by 3.7 pg/ml and 5.9 pg/ml, C-reactive protein - by 2.0 mg/l and 3.4 mg/l in groups 1 and 2 correspondingly. Dark-field microscopy showed the decrease in the thickness of perfused boundary region by 0.05 mm and 0.28 mm, and the increase of red blood cells filling by 1.2% and 7.8% correspondingly. According to the results of ultrasound scanning of BCA after 6 months the number of atherosclerotic plaques and lumen of the vessels in the area of the plaques has not changed. BCA tone has not changed in group 1 and increased by 1-2% in group 2. Intima-media complex thickness decreased in group 1 by 0.02-0.03 mm, in group 2 - by 0.04 mm. The obtained data prove correlation of vascular status of periodontal and major blood vessels.
[Mh] Termos MeSH primário: Periodontite Crônica/diagnóstico por imagem
Periodontite Crônica/terapia
Endotélio Vascular/diagnóstico por imagem
Periodonto/irrigação sanguínea
[Mh] Termos MeSH secundário: Adulto
Idoso
Proteína C-Reativa/análise
Periodontite Crônica/cirurgia
Endotélio Vascular/patologia
Feminino
Seres Humanos
Interleucina-6/sangue
Fluxometria por Laser-Doppler
Masculino
Meia-Idade
Resultado do Tratamento
Vasodilatação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interleukin-6); 9007-41-4 (C-Reactive Protein)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170518
[St] Status:MEDLINE
[do] DOI:10.17116/stomat201796212-16


  5 / 6588 MEDLINE  
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Yamamoto, Mihoko
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[PMID]:28485212
[Au] Autor:Jasin Mansur F; Takahara S; Yamamoto M; Shimatani M; Minnatul Karim M; Noiri Y; Ebisu S; Azakami H
[Ad] Endereço:a Faculty of Agriculture, Department of Biological Chemistry , Yamaguchi University , Yamaguchi , Japan.
[Ti] Título:Purification and characterization of hemolysin from periodontopathogenic bacterium Eikenella corrodens strain 1073.
[So] Source:Biosci Biotechnol Biochem;81(6):1246-1253, 2017 Jun.
[Is] ISSN:1347-6947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Eikenella corrodens 1073 was found to show hemolytic activity when grown on sheep blood agar. A high and dose-dependent hemolytic activity was detected in the cell envelope fraction, which was further purified by ion-exchange and gel-filtration chromatography. Consequently, a 65-kDa protein with hemolytic activity was obtained, suggesting that this protein might be a hemolysin. Its N-terminal amino acid sequence was nearly identical to that of X-prolyl aminopeptidase from E. corrodens ATCC 23834. To confirm that X-prolyl aminopeptidase functions as a hemolytic factor, we expressed the hlyA gene, encoding X-prolyl aminopeptidase, in Escherichia coli. After induction with isopropyl ß-D-1-thiogalactopyranoside, a protein of about 65 kDa was purified on a Ni column, and its hemolytic activity was confirmed. Meanwhile, a strain with a disrupted hlyA gene, which was constructed by homologous recombination, did not show any hemolytic activity. These results suggested that X-prolyl aminopeptidase might function as a hemolysin in E. corrodens.
[Mh] Termos MeSH primário: Aminopeptidases/isolamento & purificação
Proteínas de Bactérias/isolamento & purificação
Eikenella corrodens/enzimologia
Eikenella corrodens/patogenicidade
Proteínas Hemolisinas/isolamento & purificação
Hemólise/efeitos dos fármacos
[Mh] Termos MeSH secundário: Aminopeptidases/genética
Aminopeptidases/metabolismo
Aminopeptidases/farmacologia
Proteínas de Bactérias/genética
Proteínas de Bactérias/metabolismo
Proteínas de Bactérias/farmacologia
Fracionamento Celular
Clonagem Molecular
Eikenella corrodens/genética
Eikenella corrodens/isolamento & purificação
Eritrócitos/citologia
Eritrócitos/efeitos dos fármacos
Escherichia coli/genética
Escherichia coli/metabolismo
Expressão Gênica
Proteínas Hemolisinas/genética
Proteínas Hemolisinas/metabolismo
Proteínas Hemolisinas/farmacologia
Recombinação Homóloga
Seres Humanos
Peso Molecular
Periodontite/microbiologia
Periodonto/microbiologia
Proteínas Recombinantes/genética
Proteínas Recombinantes/isolamento & purificação
Proteínas Recombinantes/metabolismo
Proteínas Recombinantes/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Hemolysin Proteins); 0 (Recombinant Proteins); EC 3.4.11.- (Aminopeptidases); EC 3.4.11.9 (X-Pro aminopeptidase)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170703
[Lr] Data última revisão:
170703
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170510
[St] Status:MEDLINE
[do] DOI:10.1080/09168451.2017.1295807


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[PMID]:28474060
[Au] Autor:Li MH; Wang Y; Liao NN; Li JY; Dong Q
[Ad] Endereço:Hospital of Stomatology, Jilin University. Changchun 130021, Jilin Province, China. E-mail:39476540@qq.com.
[Ti] Título:[Changes of TGF-ß1 expression during orthodontic tooth movement in rats with osteoporosis].
[So] Source:Shanghai Kou Qiang Yi Xue;26(1):17-20, 2017 Feb.
[Is] ISSN:1006-7248
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:PURPOSES: To observe the expression and distribution of TGF-ß1 in periodontal tissue under intervention of Strontium ranelate and Qianggu capsule during orthodontic tooth movement in rats, and explore the efficacy of the 2 drugs. METHODS: Seventy male SD rats of 3 months old were selected in the study, and randomly divided into control group, model control group, Strontium ranelate group, Qianggu capsule group, each group had 15 animals. Retinoic acid was given by gavage to animals in the control group, Strontium ranelate group, Qianggu capsule group for 2 weeks, and bone density was detected to determine successful establishment of osteoporosis model. All rats were installed orthodontic device, and were sacrificed at 7 days, 14 days and 21 days, respectively. The tissue blocks of the first maxillary molar and adjacent alveolar bone were taken for H-E staining, immunohistochemical staining and semi-quantitative analysis was used to detect TGF-ß1 expression in periodontal tissues. The data were statistically analyzed by SPSS 17.0 software package. RESULTS: TGF- beta 1 expression was significantly increased in Strontium ranelate group and Qianggu capsule group compared with control group (P<0.05); TGF- beta 1 expression in Strontium ranelate group was significantly stronger than that of Qianggu capsule group (P<0.05). CONCLUSIONS: Strontium ranelate and Qianggu capsule could enhance the expression of TGF- beta 1 and promote bone metabolism in osteoporosis rats, which is helpful to the movement of healthy teeth; the effect of Strontium ranelate is stronger than Qianggu capsule.
[Mh] Termos MeSH primário: Osteoporose/metabolismo
Técnicas de Movimentação Dentária
Fator de Crescimento Transformador beta1/metabolismo
[Mh] Termos MeSH secundário: Animais
Densidade Óssea
Conservadores da Densidade Óssea
Osso e Ossos
Seres Humanos
Masculino
Dente Molar
Compostos Organometálicos
Osteoporose Pós-Menopausa
Periodonto
Ratos
Ratos Sprague-Dawley
Tiofenos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bone Density Conservation Agents); 0 (Organometallic Compounds); 0 (TGFB1 protein, human); 0 (Thiophenes); 0 (Transforming Growth Factor beta1); 04NQ160FRU (strontium ranelate)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170608
[Lr] Data última revisão:
170608
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170506
[St] Status:MEDLINE


  7 / 6588 MEDLINE  
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[PMID]:28474059
[Au] Autor:Zhu SY; Yuan CY; Liu ZX; Li XM; Wang PL
[Ad] Endereço:Dental Implant Center, Xuzhou Medical College Affiliated Xuzhou Stomatological Hospital. Xuzhou 221001, Jiangsu Province, China. E-mail:zhushaoyuegg@163.com.
[Ti] Título:[The mechanism of corticotomy accelerating orthodontic tooth movement in SD rats].
[So] Source:Shanghai Kou Qiang Yi Xue;26(1):12-16, 2017 Feb.
[Is] ISSN:1006-7248
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:PURPOSE: To study the influences of corticotomy on orthodontic tooth movement (OTM) and the underlying mechanism in rats. METHODS: Forty-eight female Sprague-Dawley rats were randomly assigned to corticotomy group (Cort, 24 rats) or sham-corticotomy group (Sham, 24 rats). All rats were subjected OTM after corticotomy or sham surgery. 6 rats of each group were sacrificed at 0, 1, 3 and 7 day of OTM. OTM were measured with an electronic digital caliper. Osteoclasts were counted in pressure side with TRAP. RANKL were measure by IHC at pressure side. The data were analyzed with SPSS 16.0 software package. RESULTS: OTM at the 1 and 7 day in Cort group increased compared with sham group. Number of TRAP positive osteoclasts in pressure side increased in Cort group at the 3 and 7 day. Expression of RANKL in pressure side also increased in Cort group at the 3 and 7 day. CONCLUSIONS: Corticotomy accelerates OTM in rats and it may result from promoted bone resorption via increased RANKL expression in periodontal tissue.
[Mh] Termos MeSH primário: Procedimentos Cirúrgicos Bucais/métodos
Técnicas de Movimentação Dentária/métodos
[Mh] Termos MeSH secundário: Animais
Reabsorção Óssea
Masculino
Osteoclastos
Periodonto
Ligante RANK
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RANK Ligand); 0 (TNFSF11 protein, human)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170608
[Lr] Data última revisão:
170608
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170506
[St] Status:MEDLINE


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[PMID]:28415444
[Au] Autor:H R R; Dhamecha D; Jagwani S; Patil D; Hegde S; Potdar R; Metgud R; Jalalpure S; Roy S; Jadhav K; Tiwari NK; Koduru S; Hugar S; Dodamani S
[Ad] Endereço:Department of Periodontics, KLE VK Institute of Dental Sciences, KLE University, Nehru Nagar, Belgaum 590010, Karnataka, India. Electronic address: dr.rashree@gmail.com.
[Ti] Título:Formulation of thermoreversible gel of cranberry juice concentrate: Evaluation, biocompatibility studies and its antimicrobial activity against periodontal pathogens.
[So] Source:Mater Sci Eng C Mater Biol Appl;75:1506-1514, 2017 Jun 01.
[Is] ISSN:1873-0191
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The present work aims to investigate the efficacy of thermoreversible gel of cranberry juice concentrate (CJC) as local drug delivery for the treatment of periodontitis. CJC was initially tested for its antimicrobial activities like MIC, MBC, antiadhesion, antibiofilm and time kill assay against the panel of organisms (S. mutans (SM), E. faecalis (EF), A. actinomycetemcomitans (AA), P. gingivalis (PG), T. forsythia (TF)) responsible for periapical and periodontal infections. Antimicrobial activity of CJC showed MIC value of 50mg/ml and MBC value of 100mg/ml with desirable antiadhesion (83-90%) and antibiofilm activity (70-85%). CJC was evaluated for its biocompatibility using periodontal fibroblasts by cell based MTT assay and found to be nontoxic. Influence of CJC on periodontopathogen PG derived virulence factors (fimA and kgp) was studied using real time polymerase chain reaction (RT-PCR) technique wherein down regulation of selected genes demonstrated inhibitory effect against PG virulence factors. Thermoreversible gel of CJC was formulated by cold method using poloxamer 407 as thermosensitive polymer and carbopol 934 as mucoadhesive polymer and evaluated for its gelation temperature, viscosity, gel strength and mucoadhesive strength. Comparison of optimized thermoreversible gel of CJC (500mg/ml) with commercially available chlorhexidine gluconate gel (0.2%) using agar well diffusion demonstrated equal zone of inhibition against SM, EF, AA, PG & TF. Hence the formulated thermoreversible gel of CJC could serve as a novel herbal alternative to currently available periodontal treatment modalities.
[Mh] Termos MeSH primário: Antibacterianos
Bactérias/crescimento & desenvolvimento
Fibroblastos/metabolismo
Sucos de Frutas e Vegetais
Teste de Materiais
Periodonto/microbiologia
Vaccinium macrocarpon/química
[Mh] Termos MeSH secundário: Antibacterianos/química
Antibacterianos/farmacologia
Células Cultivadas
Avaliação Pré-Clínica de Medicamentos
Fibroblastos/citologia
Géis
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Gels)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE


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Texto completo SciELO Brasil
[PMID]:28403363
[Au] Autor:Duque C; João MF; Camargo GA; Teixeira GS; Machado TS; Azevedo RS; Mariano FS; Colombo NH; Vizoto NL; Mattos-Graner RO
[Ad] Endereço:Universidade Estadual Paulista, Faculdade de Odontologia de Araçatuba, Departamento de Odontologia Infantil e Social, Araçatuba, São Paulo, Brasil.
[Ti] Título:Microbiological, lipid and immunological profiles in children with gingivitis and type 1 diabetes mellitus.
[So] Source:J Appl Oral Sci;25(2):217-226, 2017 Mar-Apr.
[Is] ISSN:1678-7765
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Objective: The aim of this study was to compare the prevalence of periodontal pathogens, systemic inflammatory mediators and lipid profiles in type 1 diabetes children (DM) with those observed in children without diabetes (NDM), both with gingivitis. Material and methods: Twenty-four DM children and twenty-seven NDM controls were evaluated. The periodontal status, glycemic and lipid profiles were determined for both groups. Subgingival samples of periodontal sites were collected to determine the prevalence of periodontal microorganisms by PCR. Blood samples were collected for IL-1-ß, TNF-α and IL-6 analysis using ELISA kits. Results: Periodontal conditions of DM and NDM patients were similar, without statistical differences in periodontal indices. When considering patients with gingivitis, all lipid parameters evaluated were highest in the DM group; Capnocytophaga sputigena and Capnocytophaga ochracea were more prevalent in the periodontal sites of DM children. "Red complex" bacteria were detected in few sites of DM and NDM groups. Fusobacterium nucleatum and Campylobacter rectus were frequently found in both groups. Similar levels of IL-1-ß, TNF-α and IL-6 were detected in DM and NDM children. Conclusion: Clinical and immunological profiles are similar between DM and NDM children. The presence of Capnocytophaga sputigena and Capnocytophaga ochracea were associated with gingivitis in DM children.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 1/epidemiologia
Diabetes Mellitus Tipo 1/microbiologia
Gengivite/epidemiologia
Gengivite/microbiologia
Periodonto/microbiologia
[Mh] Termos MeSH secundário: Adolescente
Brasil/epidemiologia
Capnocytophaga/isolamento & purificação
Criança
Colesterol/sangue
Dentição Permanente
Diabetes Mellitus Tipo 1/imunologia
Ensaio de Imunoadsorção Enzimática
Feminino
Gengivite/imunologia
Seres Humanos
Interleucina-1beta/sangue
Interleucina-6/sangue
Masculino
Índice Periodontal
Reação em Cadeia da Polimerase
Estatísticas não Paramétricas
Dente Decíduo/microbiologia
Triglicerídeos/sangue
Fator de Necrose Tumoral alfa/sangue
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interleukin-1beta); 0 (Interleukin-6); 0 (Triglycerides); 0 (Tumor Necrosis Factor-alpha); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170530
[Lr] Data última revisão:
170530
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE


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[PMID]:28337876
[Au] Autor:Li M; Li R; Jin Q; Pang J; Xu Z
[Ad] Endereço:Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Ninth People’s Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
[Ti] Título:The efficacy of proanthocyanidins and secnidazole in the treatment of chronic periodontitis after scaling and root planing therapy.
[So] Source:J Biol Regul Homeost Agents;31(1):93-97, 2017 Jan-Mar.
[Is] ISSN:0393-974X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:The aim of this study is to evaluate the clinical and microbiological effect of the systemic antibiotic therapy of proanthocyanidins and secnidazole on periodontitis. Seventy-five subjects with chronic periodontitis were randomly divided into two treatment groups (secnidazole or proanthocyanidins) and one placebo control group (25 cases each). Plaque index (PI), gingival index (GI), gingival bleeding index (BI), probing pocket depth (PPD), and clinical attachment level (CAL) were carried out at baseline, post-treatment and 3 months after treatment. Microbial analysis was performed at baseline and post-treatment. The results show that the two treatment groups had greater mean reduction in BI, GI, and PPD evaluated at both post-treatment and 3 months after treatment compared to the control group (p less than 0.05), but there were no significant differences in those of PI and CAL (except CAL evaluated at post-treatment, p 0.05). After treatment, culturable bacteria counts significantly decreased. In conclusion, the adjunctive use of proanthocyanidins or secnidazole in combination with scaling and root planing in adults with periodontitis is effective in reducing the pathogenic flora and achieves significantly better clinical results to a certain degree.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Infecções Bacterianas/tratamento farmacológico
Periodontite Crônica/tratamento farmacológico
Metronidazol/análogos & derivados
Proantocianidinas/uso terapêutico
Aplainamento Radicular
[Mh] Termos MeSH secundário: Adulto
Infecções Bacterianas/diagnóstico
Infecções Bacterianas/microbiologia
Infecções Bacterianas/cirurgia
Carga Bacteriana
Periodontite Crônica/diagnóstico
Periodontite Crônica/microbiologia
Periodontite Crônica/cirurgia
Índice de Placa Dentária
Método Duplo-Cego
Feminino
Bactérias Gram-Negativas/efeitos dos fármacos
Bactérias Gram-Negativas/crescimento & desenvolvimento
Bactérias Gram-Positivas/efeitos dos fármacos
Bactérias Gram-Positivas/crescimento & desenvolvimento
Seres Humanos
Masculino
Metronidazol/uso terapêutico
Meia-Idade
Índice Periodontal
Periodonto/efeitos dos fármacos
Periodonto/microbiologia
Periodonto/cirurgia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Proanthocyanidins); 140QMO216E (Metronidazole); R3459K699K (secnidazole)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170601
[Lr] Data última revisão:
170601
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE



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