Base de dados : MEDLINE
Pesquisa : A14.549.167.646.374 [Categoria DeCS]
Referências encontradas : 1433 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 144 ir para página                         

  1 / 1433 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
[PMID]:28653052
[Au] Autor:Wilson D; Soileau K; Esquivel J; Cordero A; Buchman W; Maney P; Archontia Palaiologou A
[Ti] Título:Assessment of gingival symmetry with digital measuring tools and its reproducibility.
[So] Source:Int J Esthet Dent;12(2):232-242, 2017.
[Is] ISSN:2198-591X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The aim of this study was to investigate the accuracy of digital measuring tools to measure the position of gingival zeniths and to assess its reproducibility between different examiners. MATERIALS AND METHODS: A total of 108 subjects were photographed at the Louisiana State University School of Dentistry. The settings, positioning of the digital camera, and subjects' Frankfurt levels were standardized. A photograph was taken of the six anterior maxillary teeth of each subject, and their corresponding free gingival margins. Digital caliper measurements were taken intraorally from the zenith to the incisal edge of the right maxillary central incisor. A reference line was drawn across the screen on each image at the level of the zenith of tooth 8. Three calibrated examiners then measured the distance from the reference line to the zeniths of the other five anterior maxillary teeth. RESULTS/CONCLUSIONS: There was no statistically significant difference between the examiners regarding any of the measurements. Central incisors were at the same level in 84.24% of the subjects, and lateral incisors were within 0.5 mm of central incisors in only 58% of the subjects. Canine zeniths were within 0.5 mm of each other in 43% of the subjects. Only 28% of the subjects presented with zeniths of tooth 6 to tooth 11 within 0.5 mm of each other. Lateral incisors were at or beneath the line drawn from central incisors to cuspids in 90.8% of the subjects. Standardized digital photography taken with the aid of a stadiometer and used to evaluate esthetic parameters allowed for reproducible measurements.
[Mh] Termos MeSH primário: Dente Canino/anatomia & histologia
Gengiva/anatomia & histologia
Incisivo/anatomia & histologia
Odontometria/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Inserção Epitelial/anatomia & histologia
Estética Dentária
Feminino
Seres Humanos
Masculino
Meia-Idade
Fotografia Dentária
Reprodutibilidade dos Testes
Coroa do Dente/anatomia & histologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE


  2 / 1433 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28086031
[Au] Autor:Maeno M; Lee C; Kim DM; Da Silva J; Nagai S; Sugawara S; Nara Y; Kihara H; Nagai M
[Ad] Endereço:1 Department of Restorative Dentistry and Biomaterials Sciences, Harvard School of Dental Medicine, Boston, MA, USA.
[Ti] Título:Function of Platelet-Induced Epithelial Attachment at Titanium Surfaces Inhibits Microbial Colonization.
[So] Source:J Dent Res;96(6):633-639, 2017 Jun.
[Is] ISSN:1544-0591
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to evaluate the barrier function of platelet-induced epithelial sheets on titanium surfaces. The lack of functional peri-implant epithelial sealing with basal lamina (BL) attachment at the interface of the implant and the adjacent epithelium allows for bacterial invasion, which may lead to peri-implantitis. Although various approaches have been reported to combat bacterial infection by surface modifications to titanium, none of these have been successful in a clinical application. In our previous study, surface modification with protease-activated receptor 4-activating peptide (PAR4-AP), which induced platelet activation and aggregation, was successful in demonstrating epithelial attachment via BL and epithelial sheet formation on the titanium surface. We hypothesized that the platelet-induced epithelial sheet on PAR4-AP-modified titanium surfaces would reduce bacterial attachment, penetration, and invasion. Titanium surface was modified with PAR4-AP and incubated with platelet-rich plasma (PRP). The aggregated platelets released collagen IV, a critical BL component, onto the PAR4-AP-modified titanium surface. Then, human gingival epithelial cells were seeded on the modified titanium surface and formed epithelial sheets. Green fluorescent protein (GFP)-expressing Escherichia coli was cultured onto PAR4-AP-modified titanium with and without epithelial sheet formation. While Escherichia coli accumulated densely onto the PAR4-AP titanium lacking epithelial sheet, few Escherichia coli were observed on the epithelial sheet on the PAR4-AP surface. No bacterial invasion into the interface of the epithelial sheet and the titanium surface was observed. These in vitro results indicate the efficacy of a platelet-induced epithelial barrier that functions to prevent bacterial attachment, penetration, and invasion on PAR4-AP-modified titanium.
[Mh] Termos MeSH primário: Plaquetas/fisiologia
Implantes Dentários
Materiais Dentários/química
Inserção Epitelial
Peri-Implantite/prevenção & controle
Receptores de Trombina/química
Titânio/química
[Mh] Termos MeSH secundário: Aderência Bacteriana/efeitos dos fármacos
Dente Suporte
Escherichia coli
Seres Humanos
Técnicas In Vitro
Peri-Implantite/etiologia
Plasma Rico em Plaquetas
Propriedades de Superfície
Cicatrização
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dental Implants); 0 (Dental Materials); 0 (Receptors, Thrombin); 0 (protease-activated receptor 4); D1JT611TNE (Titanium)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170114
[St] Status:MEDLINE
[do] DOI:10.1177/0022034516688888


  3 / 1433 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27861650
[Au] Autor:Mehl C; Gassling V; Schultz-Langerhans S; Açil Y; Bähr T; Wiltfang J; Kern M
[Ti] Título:Influence of Four Different Abutment Materials and the Adhesive Joint of Two-Piece Abutments on Cervical Implant Bone and Soft Tissue.
[So] Source:Int J Oral Maxillofac Implants;31(6):1264-1272, 2016 Nov/Dec.
[Is] ISSN:1942-4434
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The main aim of this study was to evaluate the influence of four different abutment materials and the adhesive joint of two-piece abutments on the cervical implant bone and soft tissue. MATERIALS AND METHODS: Sixty-four titanium implants (Camlog Conelog; 4.3 ± 9 mm) were placed bone level into the edentulous arches of four minipigs. Four different types of abutments were placed at implant exposure: zirconium dioxide, lithium disilicate, and titanium bonded to a titanium luting base with resin cement; one-piece titanium abutments served as the control. The animals were sacrificed 6 months after implant exposure, and the bone-to-implant contact (BIC) area, sulcus depth, the length of the junctional epithelium and the connective tissue, the biologic width, and first cervical BIC-implant shoulder distance were measured using histomorphometry and light and fluorescence microscopy. RESULTS: Overall, 14 implants were lost (22%). At exposure, the implant shoulder-bone distance was 0.6 ± 0.7 mm. Six months later, the bone loss was 2.1 ± 1.2 mm measured histomorphometrically. There was a significant difference between the two measurements (P ≤ .0001). No significant influence could be found between any of the abutment materials with regard to bone loss or soft tissue anatomy (P > .05), with the exception of zirconium dioxide and onepiece titanium abutments when measuring the length of the junctional epithelium (P ≤ .01). The maxilla provided significantly more soft tissue and less bone loss compared with the mandible (P ≤ .02). CONCLUSION: All tested abutment materials and techniques seem to be comparable with regard to soft tissue properties and the cervical bone level.
[Mh] Termos MeSH primário: Perda do Osso Alveolar/patologia
Dente Suporte
Implantação Dentária Endo-Óssea/métodos
Implantes Dentários
Planejamento de Prótese Dentária
Inserção Epitelial/patologia
Arcada Parcialmente Edêntula/cirurgia
[Mh] Termos MeSH secundário: Adesivos
Processo Alveolar/patologia
Análise de Variância
Animais
Porcelana Dentária
Modelos Animais de Doenças
Mandíbula/cirurgia
Maxila/cirurgia
Suínos
Porco Miniatura
Titânio
Zircônio
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adhesives); 0 (Dental Implants); 0 (lithia disilicate); 12001-21-7 (Dental Porcelain); C6V6S92N3C (Zirconium); D1JT611TNE (Titanium); S38N85C5G0 (zirconium oxide)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:161119
[St] Status:MEDLINE
[do] DOI:10.11607/jomi.5321


  4 / 1433 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27560671
[Au] Autor:Neiva R; Tovar N; Jimbo R; Gil LF; Goldberg P; Barbosa JP; Lilin T; Coelho PG
[Ti] Título:The Effect of Laser-Etched Surface Design on Soft Tissue Healing of Two Different Implant Abutment Systems: An Experimental Study in Dogs.
[So] Source:Int J Periodontics Restorative Dent;36(5):673-9, 2016 Sep-Oct.
[Is] ISSN:1945-3388
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study describes the early soft tissue morphology around two different implant systems that received either smooth or laser-etched abutments in a beagle dog model. Implants were placed in the healed mandibular molar region of eight beagle dogs and allowed to heal for 7 weeks. When the most apical aspect of the junctional epithelium (JE) was above or within the upper half of the laser-etched region, fibers were oriented perpendicular to the abutment surface. In contrast, JE positioned within the lower half of the laser-etched region or within or below the implant-abutment gap level presented fibers oriented parallel to the abutment surface.
[Mh] Termos MeSH primário: Projeto do Implante Dentário-Pivô
Implantação Dentária Endo-Óssea/métodos
Mandíbula/cirurgia
Cicatrização/fisiologia
[Mh] Termos MeSH secundário: Animais
Cães
Inserção Epitelial/fisiologia
Gengiva/fisiologia
Lasers
Propriedades de Superfície
Retalhos Cirúrgicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:160826
[St] Status:MEDLINE
[do] DOI:10.11607/prd.2940


  5 / 1433 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26635280
[Au] Autor:Lee G; Kim HJ; Kim HM
[Ad] Endereço:Laboratory for the Study of Molecular Biointerfaces, Department of Oral Histology and Developmental Biology, Program of Cell and Developmental Biology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea.
[Ti] Título:RhoA-JNK Regulates the E-Cadherin Junctions of Human Gingival Epithelial Cells.
[So] Source:J Dent Res;95(3):284-91, 2016 Mar.
[Is] ISSN:1544-0591
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The junctional epithelium (JE) is unique with regard to its wide intercellular spaces and sparsely developed intercellular junctions. Thus, knowledge of the molecular mechanisms that regulate the formation of the intercellular junctions of the junctional epithelium may be essential to understand the pathophysiology of the JE. HOK-16B cells, a normal human gingival epithelial cell line, were used to identify the molecules involved in the regulation of the formation of intercellular E-cadherin junctions between human gingival epithelial cells. Activation of c-Jun N-terminal kinase (JNK) disrupted the intercellular junctions through the dissociation of E-cadherin. The role of JNK in the formation of these E-cadherin junctions was further confirmed by demonstrating that JNK inhibition induced the formation of intercellular E-cadherin junctions. The upstream signaling of JNK was also examined. Activation of the small GTPase RhoA disrupted the formation of E-cadherin junctions between HOK-16B cells, which was accompanied by JNK activation. Disruption of these intercellular junctions upon RhoA activation was prevented when JNK activity was inhibited. In contrast, RhoA inactivation led to HOK-16B cell aggregation and the formation of intercellular junctions, even under conditions in which the cellular junctions were naturally disrupted by growth on a strongly adhesive surface. Furthermore, the JE of mouse molars had high JNK activity associated with low E-cadherin expression, which was reversed in the other gingival epithelia, including the sulcular epithelium. Interestingly, JNK activity was increased in cells grown on a solid surface, where cells showed higher RhoA activity than those grown on soft surfaces. Together, these results indicate that the decreased formation of intercellular E-cadherin junctions within the JE may be coupled to high JNK activity, which is activated by the upregulation of RhoA on solid tooth surfaces.
[Mh] Termos MeSH primário: Caderinas/fisiologia
Gengiva/citologia
Junções Intercelulares/fisiologia
Proteínas Quinases JNK Ativadas por Mitógeno/fisiologia
Proteína rhoA de Ligação ao GTP/fisiologia
[Mh] Termos MeSH secundário: Animais
Anisomicina/farmacologia
Antracenos/farmacologia
Caderinas/efeitos dos fármacos
Adesão Celular/efeitos dos fármacos
Técnicas de Cultura de Células
Linhagem Celular
Meios de Cultura
Ativação Enzimática
Inserção Epitelial/citologia
Inserção Epitelial/efeitos dos fármacos
Células Epiteliais/citologia
Células Epiteliais/efeitos dos fármacos
Fibronectinas/química
Gengiva/efeitos dos fármacos
Seres Humanos
Junções Intercelulares/efeitos dos fármacos
Proteínas Quinases JNK Ativadas por Mitógeno/antagonistas & inibidores
Proteínas Quinases JNK Ativadas por Mitógeno/farmacologia
Sistema de Sinalização das MAP Quinases/fisiologia
Camundongos
Inibidores da Síntese de Proteínas/farmacologia
Proteína rhoA de Ligação ao GTP/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anthracenes); 0 (Cadherins); 0 (Culture Media); 0 (Fibronectins); 0 (Protein Synthesis Inhibitors); 1TW30Y2766 (pyrazolanthrone); 6C74YM2NGI (Anisomycin); EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases); EC 3.6.5.2 (rhoA GTP-Binding Protein)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:151205
[St] Status:MEDLINE
[do] DOI:10.1177/0022034515619375


  6 / 1433 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Poi, Wilson Roberto
Sonoda, Celso Koogi
Texto completo
[PMID]:26205067
[Au] Autor:Melo ME; Silva CA; de Souza Gomes WD; da Silva VF; Brandini DA; Poi WR; Castilho LR; Sonoda CK; Panzarini SR
[Ad] Endereço:Department of Surgery and Integrated Clinics, School of Dentistry of Araçatuba, UNESP -Univ Estadual Paulista, Araçatuba, São Paulo, Brazil.
[Ti] Título:Immediate tooth replantation in rats: effect of systemic antibiotic therapy with amoxicillin and tetracycline.
[So] Source:Clin Oral Investig;20(3):523-32, 2016 Apr.
[Is] ISSN:1436-3771
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The aim of this study was to evaluate the influence of systemic administration of antibiotics (amoxicillin and tetracycline) at the different phases of the repair process (7, 15, 30 days) in immediate rat tooth replantation. MATERIALS AND METHODS: Ninety rats had their incisors extracted and stored in saline for 5 min. Next, the teeth were replanted, and the animals were assigned to three groups according to the antibiotic administered by oral gavage: control group, amoxycillin group, and tetracycline group. Euthanasia was performed at 7, 15, and 30 days after replantation. RESULTS: Regardless of the evaluation period, the connective tissue underlying the epithelial attachment and the periodontal ligament showed statistically significant difference relative to the acute inflammatory infiltrate, which was more intense in the control group followed by the tetracycline group. CONCLUSION: These results point to the fact that systemic antibiotic therapy (SAT) in immediate tooth replantation is beneficial to pulpal and periodontal ligament repair and that amoxycillin is an excellent option. CLINICAL RELEVANCE: There is a lack of randomized studies assessing how the use of systemic antibiotics could influence tooth healing after immediate replantation.
[Mh] Termos MeSH primário: Amoxicilina/farmacologia
Inserção Epitelial/efeitos dos fármacos
Incisivo/cirurgia
Ligamento Periodontal/efeitos dos fármacos
Tetraciclina/farmacologia
Reimplante Dentário/métodos
[Mh] Termos MeSH secundário: Amoxicilina/administração & dosagem
Animais
Masculino
Ratos
Ratos Wistar
Tetraciclina/administração & dosagem
Cicatrização/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
804826J2HU (Amoxicillin); F8VB5M810T (Tetracycline)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:150725
[St] Status:MEDLINE
[do] DOI:10.1007/s00784-015-1534-0


  7 / 1433 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26154781
[Au] Autor:Allon I; Lammert KM; Iwase R; Spears R; Wright JM; Naidu A
[Ad] Endereço:Department of Oral Pathology & Oral Medicine, School of Dental Medicine, Tel-Aviv University, Tel Aviv, Israel.
[Ti] Título:Localized juvenile spongiotic gingival hyperplasia possibly originates from the junctional gingival epithelium-an immunohistochemical study.
[So] Source:Histopathology;68(4):549-55, 2016 Mar.
[Is] ISSN:1365-2559
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: To immunohistochemically evaluate the cytokeratin (CK) pattern of expression in localized juvenile spongiotic gingival hyperplasia (LJSGH) as compared with the gingival epithelium (GE). METHODS AND RESULTS: Ten cases of LJSGH were semiquantitatively evaluated for the immunohistochemical pattern of CK1/10, CK4, CK8/18, and CK19. GE controls were taken from 10 cases of reactive gingival fibroepithelial hyperplasia. GEs showed mean positivity rates of 80% for both CK1/10 and CK4, and 5% for both CK8/18 and CK19. LJSGHs showed mean positivity rates of 65% for CK19, 60% for CK8/18, 30% for CK4, and 5% for CK1/10. The differences between LJSGHs and GEs were statistically significant (P < 0.01). CONCLUSIONS: The LJSGH pattern of CK expression is reminiscent of the profile described in the literature for the junctional epithelium (JE). Possibly, JE exteriorized from the gingival sulcus would be more prone to irritation from a variety of sources, resulting in inflammation and hyperplasia, with the subsequent development of LJSGH.
[Mh] Termos MeSH primário: Inserção Epitelial/patologia
Hiperplasia Gengival/patologia
[Mh] Termos MeSH secundário: Adolescente
Criança
Feminino
Gengiva/patologia
Seres Humanos
Imuno-Histoquímica
Queratinas/análise
Queratinas/biossíntese
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
68238-35-7 (Keratins)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150709
[St] Status:MEDLINE
[do] DOI:10.1111/his.12774


  8 / 1433 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:25864924
[Au] Autor:Mori G; Sasaki H; Makabe Y; Yoshinari M; Yajima Y
[Ad] Endereço:Department of Oral and Maxillofacial Implantology, Tokyo Dental College, Tokyo, Japan.
[Ti] Título:The genes Scgb1a1, Lpo and Gbp2 characteristically expressed in peri-implant epithelium of rats.
[So] Source:Clin Oral Implants Res;27(12):e190-e198, 2016 Dec.
[Is] ISSN:1600-0501
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The peri-implant epithelium (PIE) plays an important role in the prevention against initial stage of inflammation. To minimize the risk of peri-implantitis, it is necessary to understand the biological characteristics of the PIE. The aim of this study was to investigate the characteristic gene expression profile of PIE as compared to junctional epithelium (JE) using laser microdissection and microarray analysis. METHODS: Left upper first molars of 4-week-old rat were extracted, and titanium alloy implants were placed. Four weeks after surgery, samples were harvested by laser microdissection, and total RNA samples were isolated. Comprehensive analyses of genes expressed in the JE and PIE were performed using microarray analysis. Confirmation of the differential expression of selected genes was performed by quantitative real-time polymerase chain reaction and immunohistochemistry. RESULTS: The microarray analysis showed that 712 genes were more than twofold change upregulated in the PIE compared with the JE. Genes Scgb1a1 were significantly upregulated more than 19.1-fold, Lpo more than 19.0-fold, and Gbp2 more than 8.9-fold, in the PIE (P < 0.01). Immunohistochemical localization of SCGB1A1, LPO, and GBP2 was observed in PIE. CONCLUSION: The present results suggested that genes Scgb1a1, Lpo, and Gbp2 are characteristically expressed in the PIE.
[Mh] Termos MeSH primário: Implantação Dentária Endo-Óssea
Inserção Epitelial/metabolismo
Epitélio/metabolismo
Proteínas de Ligação ao GTP/genética
Lactoperoxidase/genética
Regulação para Cima
Uteroglobina/genética
[Mh] Termos MeSH secundário: Animais
Proteínas de Ligação ao GTP/metabolismo
Imuno-Histoquímica
Lactoperoxidase/metabolismo
Microdissecção e Captura a Laser
Masculino
Análise de Sequência com Séries de Oligonucleotídeos
Peri-Implantite/genética
Ratos Sprague-Dawley
Reação em Cadeia da Polimerase em Tempo Real
Uteroglobina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gbp2 protein, rat); 0 (Scgb1a1 protein, rat); 9060-09-7 (Uteroglobin); EC 1.11.1.- (Lactoperoxidase); EC 3.6.1.- (GTP-Binding Proteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:150414
[St] Status:MEDLINE
[do] DOI:10.1111/clr.12601


  9 / 1433 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:24889401
[Au] Autor:Lee J; Fiorini T; Gamborena I; Wenzel BA; Schüpbach P; Wikesjö UM; Susin C
[Ad] Endereço:Laboratory for Applied Periodontal and Craniofacial Regeneration, Georgia Regents University, Augusta, GA, USA.
[Ti] Título:Effect of Platform Shift/Switch on Crestal Bone Levels and Mucosal Profile Following Flapless Surgery and Crestal/Subcrestal Implant Placement.
[So] Source:Clin Implant Dent Relat Res;18(1):73-81, 2016 Feb.
[Is] ISSN:1708-8208
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Crestal remodeling/bone loss appears a common sequel to dental implant placement. Several hypotheses and clinical strategies have been advanced to explain and avert crestal remodeling; however, causative mechanisms remain unclear and the efficacy of clinical protocol uncertain. OBJECTIVE: The objective of the present study was to provide a histologic record of crestal versus subcrestal implant placement on crestal remodeling and mucosal profile comparing platform shift/switch and standard abutments following flapless implant surgery using a dog model. METHODS: Four dental implants each were placed into the left and right edentulated posterior mandibles in five adult male hound-Labrador mongrel dogs using a flapless approach including crestal versus subcrestal placement and using platform shift versus standard abutments. Block biopsies were collected for histological/histometric analysis following an 8-week healing interval. RESULTS: Both crestal and subcrestal implant installation resulted in significant crestal remodeling and bone loss, in particular at buccal sites, without significant differences between platform shift/switch and standard abutments. Implants installed subcrestally exhibited a significantly taller mucosal profile over crestal-level implants without significant differences between platform shift/switch and standard abutments; the epithelial attachment at all times arrested on the abutment surface. CONCLUSIONS: Comparing platform shift/switch versus standard abutments using a minimally invasive flapless approach including crestal or subcrestal implant placement, the platform shift/switch abutments offer no selective advantage over standard abutments.
[Mh] Termos MeSH primário: Perda do Osso Alveolar/etiologia
Processo Alveolar/cirurgia
Projeto do Implante Dentário-Pivô
Implantação Dentária Endo-Óssea/métodos
[Mh] Termos MeSH secundário: Processo Alveolar/patologia
Animais
Biópsia
Remodelação Óssea
Cães
Inserção Epitelial/patologia
Masculino
Cicatrização
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170630
[Lr] Data última revisão:
170630
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:140604
[St] Status:MEDLINE
[do] DOI:10.1111/cid.12243


  10 / 1433 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
[PMID]:26412389
[Au] Autor:Wazen RM; Moffatt P; Ponce KJ; Kuroda S; Nishio C; Nanci A
[Ad] Endereço:PO Box 6128, Station Centre-Ville, Montreal, QC, H3C 3J4, Canada.antonio.nanci@umontreal.ca.
[Ti] Título:Inactivation of the Odontogenic ameloblast-associated gene affects the integrity of the junctional epithelium and gingival healing.
[So] Source:Eur Cell Mater;30:187-99, 2015 Sep 28.
[Is] ISSN:1473-2262
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:Odontogenic ameloblast-associated (ODAM) belongs to the secretory calcium-binding phosphoprotein (SCPP) gene cluster. It is expressed by the epithelial ameloblasts during the accrued mineralisation of enamel and by cells of the junctional epithelium (JE), a specialised portion of the gingiva that plays a critical role in periodontal health. In both cases, ODAM localises at the interface between the cells and the tooth surface. It is also present among the cells of the JE, and is distinctively highly expressed in many epithelial tumours. ODAM has been proposed to be a matricellular protein implicated in the adhesion of epithelial cells to tooth surfaces, and possibly in mediating cell status. To gain further understanding of the role of ODAM, we have created an Odam knockout (KO) mouse by deleting coding exons 2-6. Inactivation of the gene was verified by Southern blot, PCR, real-time qPCR and loss of immunostaining for the protein. Young Odam KO mice showed no readily apparent phenotype. No significant differences were observed in enamel volume and density, rod-interrod organisation, and its attrition. However, in older animals, the JE presented some detachment, an increase in inflammatory infiltrate, and apical down-growth. In addition, its regeneration was delayed following a gingivectomy challenge. Our results indicate that inactivation of Odam expression has no dramatic consequence on enamel but the phenotype in older animals replicates some JE changes seen during human periodontal disease. Altogether, our results suggest that ODAM plays a role in maintaining integrity of the JE.
[Mh] Termos MeSH primário: Ameloblastos/citologia
Inserção Epitelial/citologia
Células Epiteliais/citologia
Odontogênese/genética
Regeneração/genética
Cicatrização
[Mh] Termos MeSH secundário: Animais
Gengiva/citologia
Camundongos Knockout
Regeneração/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1608
[Cu] Atualização por classe:150928
[Lr] Data última revisão:
150928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150929
[St] Status:MEDLINE



página 1 de 144 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde