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[PMID]:28290616
[Au] Autor:Shen SQ; Wang R; Huang SG
[Ti] Título:Expression of the stem cell factor in fibroblasts, endothelial cells, and macrophages in periapical tissues in human chronic periapical diseases.
[So] Source:Genet Mol Res;16(1), 2017 Mar 08.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Stem cell factor (SCF), an important stem cell cytokine, has multiple functions. Fibroblasts (FBs), mature mast cells, endothelial cells (ECs), and eosinophil granulocytes can produce SCF in the inflammatory process. Therefore, we aimed to observe SCF expression in FBs, ECs, and macrophages (MPs) in periapical tissues in human chronic periapical disease and investigate the effects of cells expressing SCF in pathogenesis of the disease. Healthy (N = 20), periapical cyst (N = 15), and periapical granuloma (N = 15) tissues were fixed in 10% formalin for 48 h, embedded in paraffin, and stained with hematoxylin and eosin to observe histological changes. SCF expression was observed in FBs, ECs, and MPs in periapical tissues by double immunofluorescence. CD334, CD31, and CD14 are specific markers of FBs, ECs, and MPs, respectively. Results showed that densities of CD334-SCF double-positive FBs, CD31-SCF double-positive ECs, and CD14-SCF double-positive MPs were significantly increased in periapical tissue groups (P < 0.01). There were no significant differences in CD334-SCF double-positive FB and CD31-SCF double-positive EC levels between the two periapical tissue groups (P > 0.05). CD14-SCF double-positive MP density was considerably higher in periapical granulomas than in cysts (P < 0.01). FB, EC, and MP levels were significantly high and densities of CD334-SCF double-positive FBs, CD31-SCF double-positive ECs, and CD14-SCF double-positive MPs improved considerably in chronic periapical tissues, suggesting that the cells might be related to occurrence, development, and pathogenesis of chronic periapical disease.
[Mh] Termos MeSH primário: Células Endoteliais/metabolismo
Fibroblastos/metabolismo
Macrófagos/metabolismo
Doenças Periapicais/metabolismo
Tecido Periapical/metabolismo
Fator de Células-Tronco/biossíntese
[Mh] Termos MeSH secundário: Adulto
Idoso
Citocinas/metabolismo
Células Endoteliais/patologia
Feminino
Fibroblastos/patologia
Seres Humanos
Macrófagos/patologia
Masculino
Mastócitos/metabolismo
Mastócitos/patologia
Meia-Idade
Doenças Periapicais/patologia
Granuloma Periapical/metabolismo
Granuloma Periapical/patologia
Tecido Periapical/patologia
Cisto Radicular/metabolismo
Cisto Radicular/patologia
Fator de Células-Tronco/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Stem Cell Factor)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170412
[Lr] Data última revisão:
170412
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170315
[St] Status:MEDLINE
[do] DOI:10.4238/gmr16019394


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[PMID]:28275785
[Au] Autor:Wang HM; Zhou MQ; Hong J
[Ad] Endereço:Special Dental Consultation Clinic, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine. Shanghai 200011, China. E-mail:damingming1228@126.com.
[Ti] Título:[Histological evaluations on periapical tissues after irradiation by erbium-doped yttrium aluminum garnet laser in Labradors dogs].
[So] Source:Shanghai Kou Qiang Yi Xue;25(6):657-662, 2016 Dec.
[Is] ISSN:1006-7248
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:PURPOSE: To investigate the thermal effects on periapical tissues of Labrador dogs after intra-canal irradiation by erbium-doped yttrium aluminum garnet (Er:YAG) laser at different powers based on the antibacterial experiment of Enterococcus faecalis and Escherichia coli in root canals with an isthmus, to assess the histological changes, and to prove the safety for clinical applications. METHODS: Two hundred root canals of 10 healthy adult Labradors dogs were selected and divided into 5 groups. Excepted one as control group, root canals in other 4 groups were irradiated by Er:YAG laser with 1.5, 2.0, 2.5, 3.0 W for 30 s. Ten Labradors dogs were sacrificed at 0 (immediately after irradiation), 2 days, 2 weeks, 1 and 2 months. After preparation of pathological specimen, histological changes after laser irradiation in periapical tissues were evaluated and scores of inflammation were graded. Statistical analysis was performed using SPSS 13.0 software package. RESULTS: No significant difference was observed at the apical area between 1.5, 2.0, 2.5 W and control groups at most periods (P>0.05), whereas significant difference was observed between 3.0 W and other groups for all periods (P<0.05). CONCLUSIONS: These results suggest that if proper output powers (2.0-2.5 W) of laser irradiation are chosen, disinfection in root canals can be finished successfully and thermal effects on the periapical tissues can be minimized.
[Mh] Termos MeSH primário: Alumínio
Lasers de Estado Sólido
Tecido Periapical/patologia
Ítrio
[Mh] Termos MeSH secundário: Animais
Cavidade Pulpar
Desinfecção
Cães
Enterococcus faecalis
Érbio
Seres Humanos
Tecido Periapical/efeitos da radiação
Preparo de Canal Radicular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (yttrium-aluminum-garnet); 58784XQC3Y (Yttrium); 77B218D3YE (Erbium); CPD4NFA903 (Aluminum)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170602
[Lr] Data última revisão:
170602
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE


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[PMID]:27726882
[Au] Autor:Bukhari S; Kohli MR; Setzer F; Karabucak B
[Ad] Endereço:Department of Endodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
[Ti] Título:Outcome of Revascularization Procedure: A Retrospective Case Series.
[So] Source:J Endod;42(12):1752-1759, 2016 Dec.
[Is] ISSN:1878-3554
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The purpose of this retrospective case series was to investigate the outcome of the revascularization procedure in necrotic immature teeth. METHODS: The residents and faculty members at the University of Pennsylvania endodontic department were invited to submit consecutive revascularization cases treated by them, irrespective of the outcome, during the time period of 2009 to 2012. Twenty-eight of 35 submitted necrotic immature teeth met the inclusion criteria. The treatment protocol included minimal instrumentation and irrigation with 3% sodium hypochlorite and 17% EDTA. Triple antibiotic paste was placed for a minimum of 21 days. After blood clot induction, either EndoSequence Bioceramic Putty (Brasseler, Savannah, GA) or mineral trioxide aggregate was placed below the cementoenamel junction, and composite was used as a final restoration. The follow-up period ranged from 7 to 72 months. The outcome was assessed as complete healing (the absence of clinical signs and symptoms, complete resolution of periradicular radiolucency, increase in the root dentin thickness/length, and apical closure), incomplete healing (the absence of clinical signs and symptoms, the periapical lesion completely healed without any signs of root maturation or thickening, the periapical lesion either reduced in size or unchanged with/without radiographic signs of increasing root dentin thickness/length, or apical closure), and failure (persistent clinical signs and symptoms and/or increased size of the periradicular lesion). RESULTS: Twenty-one of 28 cases (75%) healed completely, 3 cases (10.7%) failed during the observation period and needed further treatment, and 4 cases (14%) presented with incomplete healing. CONCLUSIONS: Within the limitation of this study, the outcome of revascularization, wherein healing of periapical periodontitis and maturation of roots occurs, is fairly high, making it a viable treatment option in comparison with apexification.
[Mh] Termos MeSH primário: Necrose da Polpa Dentária/terapia
Neovascularização Fisiológica
Materiais Restauradores do Canal Radicular/uso terapêutico
Tratamento do Canal Radicular/métodos
Resultado do Tratamento
[Mh] Termos MeSH secundário: Adolescente
Adulto
Compostos de Alumínio/uso terapêutico
Antibacterianos/uso terapêutico
Apexificação/métodos
Compostos de Cálcio/uso terapêutico
Criança
Restauração Dentária Permanente/métodos
Dentina/patologia
Combinação de Medicamentos
Ácido Edético/uso terapêutico
Seres Humanos
Óxidos/uso terapêutico
Pennsylvania
Periodontite Periapical/diagnóstico por imagem
Periodontite Periapical/terapia
Tecido Periapical
Radiografia Dentária
Regeneração
Estudos Retrospectivos
Irrigantes do Canal Radicular/uso terapêutico
Preparo de Canal Radicular/métodos
Tratamento do Canal Radicular/instrumentação
Silicatos/uso terapêutico
Hipoclorito de Sódio/uso terapêutico
Dente
Ápice Dentário/diagnóstico por imagem
Ápice Dentário/patologia
Falha de Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aluminum Compounds); 0 (Anti-Bacterial Agents); 0 (Calcium Compounds); 0 (Drug Combinations); 0 (Oxides); 0 (Root Canal Filling Materials); 0 (Root Canal Irrigants); 0 (Silicates); 0 (mineral trioxide aggregate); 9G34HU7RV0 (Edetic Acid); DY38VHM5OD (Sodium Hypochlorite)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170811
[Lr] Data última revisão:
170811
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:161012
[St] Status:MEDLINE


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[PMID]:27639638
[Au] Autor:Yoo YJ; Oh JH; Lee W; Woo KM
[Ad] Endereço:Department of Conservative Dentistry, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea.
[Ti] Título:Regenerative Characteristics of Apical Papilla-derived Cells from Immature Teeth with Pulpal and Periapical Pathosis.
[So] Source:J Endod;42(11):1626-1632, 2016 Nov.
[Is] ISSN:1878-3554
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The purpose of this study was to ascertain the regenerative characteristics of apical papilla-derived cells (APDCs) from immature teeth with pulpal and periapical pathosis and thus to provide proof-of-principle evidence for further regenerative endodontic research. METHODS: Pulpal and periapical pathosis was induced in immature permanent double-rooted premolars of beagles, which were randomly assigned to experimental treatment groups: group AO (n = 14), pulp disruption and access left open; group PS (n = 14), supragingival plaque suspension-soaked cotton pellet was introduced, and access was sealed; and control (n = 7), untreated. The teeth were extracted at 2- and 4-week periods after experimental treatments. APDCs were cultured from the extracted teeth, and their cellular proliferation, differentiation characteristics, and stemness were assessed. The data were statistically analyzed. RESULTS: After 4 weeks of intentional pulpal and periapical pathosis induction period, all teeth in group PS showed features of apical periodontitis with necrotic pulp, and their APDCs showed significantly increased proliferation rate and osteogenic/odontogenic differentiation capabilities (P < .05). The stemness was maintained in all APDCs, although the stem cell population was smaller in group PS at 2-week period when the inflammatory responses were most fulminant (P < .05). CONCLUSIONS: The APDCs from immature teeth retained the regenerative characteristics with the differences according to their pulpal and periapical pathosis. The results of this study partly provide the evidence for regenerative endodontic research.
[Mh] Termos MeSH primário: Papila Dentária/fisiopatologia
Tecido Periapical/fisiopatologia
Regeneração/fisiologia
[Mh] Termos MeSH secundário: Animais
Dente Pré-Molar/patologia
Células Cultivadas
Citocinas/biossíntese
Papila Dentária/patologia
Polpa Dentária/patologia
Polpa Dentária/fisiopatologia
Necrose da Polpa Dentária/patologia
Necrose da Polpa Dentária/fisiopatologia
Necrose da Polpa Dentária/terapia
Cães
Modelos Animais
Odontogênese
Osteogênese
Periodontite Periapical/patologia
Periodontite Periapical/fisiopatologia
Periodontite Periapical/terapia
Tecido Periapical/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:160919
[St] Status:MEDLINE


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[PMID]:27625146
[Au] Autor:Kan E; Coelho MS; Reside J; Card SJ; Tawil PZ
[Ad] Endereço:Department of Endodontics, University of North Carolina School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
[Ti] Título:Periapical Microsurgery: The Effects of Locally Injected Dexamethasone on Pain, Swelling, Bruising, and Wound Healing.
[So] Source:J Endod;42(11):1608-1612, 2016 Nov.
[Is] ISSN:1878-3554
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The purpose of this prospective, double-blind, randomized clinical trial was to evaluate the postoperative healing of endodontic periapical microsurgery after local administration of dexamethasone. METHODS: Sixty patients were divided into 2 groups. The dexamethasone group received a single local submucosal injection of 4 mg dexamethasone, and the placebo group received a submucosal injection of saline solution at the conclusion of standardized periapical microsurgery. Acetaminophen and hydrocodone/acetaminophen were prescribed for pain relief. A Likert-like 6-point scale was used for self-evaluation of pain, bruising, swelling, and wound healing at 24, 48, 72, 96 hours and at 1 week. The number of tablets taken was registered. Data were analyzed using the chi-square and Fisher exact tests at a significance level of P < .05. RESULTS: No improvements in pain, bruising, and wound healing were registered at any time interval. No difference was found in the number of tablets taken for pain relief. Subjects who received the dexamethasone injection reported less swelling 24 hours after periapical microsurgery (P < .05) but showed no significant benefit for the longer follow-up periods. CONCLUSIONS: This study shows that a 4-mg dose of dexamethasone administered through a local submucosal injection after periapical microsurgery has minimal impact on pain, bruising, and apparent wound healing at any time over a 7-day interval, and the impact on swelling seems limited.
[Mh] Termos MeSH primário: Contusões/prevenção & controle
Dexametasona/administração & dosagem
Edema/prevenção & controle
Microcirurgia/métodos
Dor Pós-Operatória/prevenção & controle
Tecido Periapical/cirurgia
Cicatrização/efeitos dos fármacos
[Mh] Termos MeSH secundário: Acetaminofen/administração & dosagem
Corticosteroides/administração & dosagem
Adulto
Analgésicos não Entorpecentes/administração & dosagem
Analgésicos Opioides/uso terapêutico
Anestesia Local/métodos
Anti-Inflamatórios/administração & dosagem
Apicectomia
Método Duplo-Cego
Combinação de Medicamentos
Feminino
Seres Humanos
Hidrocodona/administração & dosagem
Inflamação/prevenção & controle
Masculino
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 0 (Analgesics, Non-Narcotic); 0 (Analgesics, Opioid); 0 (Anti-Inflammatory Agents); 0 (Drug Combinations); 0 (acetaminophen, hydrocodone drug combination); 362O9ITL9D (Acetaminophen); 6YKS4Y3WQ7 (Hydrocodone); 7S5I7G3JQL (Dexamethasone)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:160915
[St] Status:MEDLINE


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[PMID]:27510616
[Au] Autor:Qian H; Guan X; Bian Z
[Ad] Endereço:State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei 430079, P.R. China.
[Ti] Título:FSH aggravates bone loss in ovariectomised rats with experimental periapical periodontitis.
[So] Source:Mol Med Rep;14(4):2997-3006, 2016 Oct.
[Is] ISSN:1791-3004
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:Periapical bone loss is one of the prominent pathological and clinical features of periapical periodontitis. Previous studies have demonstrated that follicle­stimulating hormone (FSH) could directly affect skeletal remodelling by stimulating the formation and the function of osteoclasts in vitro and in vivo. However, the effect of FSH on periapical bone loss remained to be fully elucidated. In the current study, a rat model was established in order to verify the effect of FSH in experimental periapical lesions. It was identified that FSH aggravated the bone loss of periapical lesions. In addition, RANKL­, TRAP­, TNF­α­ and IL­1ß­positive cells were increased significantly in FSH­treated groups, which indicated that the function of FSH in bone loss may be mediated through the increasing activity of osteoclasts and the increased secretion of inflammatory cytokines. The results of the current study suggested that FSH, independent of oestrogen, may aggravate periapical bone loss by FSH receptors, which may serve an important role in the immune and inflammatory response of the host to root canal and periradicular infection during menopause.
[Mh] Termos MeSH primário: Hormônio Foliculoestimulante/sangue
Osteoclastos/patologia
Osteoporose Pós-Menopausa/complicações
Osteoporose Pós-Menopausa/patologia
Periodontite Periapical/complicações
Periodontite Periapical/patologia
[Mh] Termos MeSH secundário: Animais
Feminino
Seres Humanos
Interleucina-1beta/análise
Osteoporose Pós-Menopausa/sangue
Osteoprotegerina/análise
Ovariectomia
Periodontite Periapical/sangue
Tecido Periapical/patologia
Ligante RANK/análise
Ratos
Ratos Sprague-Dawley
Receptores do FSH/análise
Fator de Necrose Tumoral alfa/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interleukin-1beta); 0 (Osteoprotegerin); 0 (RANK Ligand); 0 (Receptors, FSH); 0 (Tnfrsf11b protein, rat); 0 (Tumor Necrosis Factor-alpha); 9002-68-0 (Follicle Stimulating Hormone)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170405
[Lr] Data última revisão:
170405
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160812
[St] Status:MEDLINE
[do] DOI:10.3892/mmr.2016.5613


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[PMID]:27220394
[Au] Autor:Zhang X; Liang J
[Ad] Endereço:Department of Endodontics, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine & Shanghai Research Institute of Stomatology & Shanghai Key Laboratory of Stomatology, Shanghai 200011, China.
[Ti] Título:[The influence of orthodontic treatment on dental pulp and periapical tissues].
[So] Source:Zhonghua Kou Qiang Yi Xue Za Zhi;51(5):317-20, 2016 May.
[Is] ISSN:1002-0098
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:The pathogenesis of pulpal and periapical diseases is related with not only bacterial infection but also physicochemical irritations such as trauma and thermal changes. During orthodontic therapy, the application of orthodontic forces on teeth may produce a series of changes in periodontal ligament, alveolar bone and pulpo-dentinal complex. This article reviewed the influences of orthodontic therapy on dental pulp and periapical tissues.
[Mh] Termos MeSH primário: Polpa Dentária
Ortodontia
Tecido Periapical
[Mh] Termos MeSH secundário: Doenças da Polpa Dentária/etiologia
Dentina
Seres Humanos
Doenças Periapicais/etiologia
Ligamento Periodontal
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160525
[Lr] Data última revisão:
160525
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:160526
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1002-0098.2016.05.013


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[PMID]:27063305
[Au] Autor:Meng LJ; Qiu LH; Yu YQ; Zhan FL; Zhang L; Zhang XF
[Ad] Endereço:Department of Endodontics, School of Stomatology, China Medical University; Liaoning Institute of Dental Research; Liaoning Key Laboratory of Oral Diseases and Research Center of Oral Disease Translational Medicine. Shenyang 110002, Liaoning Province, China. E-mail:yjswz999@163.com.
[Ti] Título:[The effect of calcium hydroxide on IL-6 and TNF-α expression of osteoblast in periapical tissues].
[So] Source:Shanghai Kou Qiang Yi Xue;25(1):32-7, 2016 Feb.
[Is] ISSN:1006-7248
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:PURPOSE: To compare the effect of calcium hydroxide in different position on pH and inflammation factor expression of periapical osteoblasts. METHODS: 140 sterilized single-rooted human teeth models were randomly divided into 6 experiment groups and one control group: Group 1-3:calcium hydroxide paste was placed in the apical half of root canal, the upper half of root canal and the pulp champer; Group 4-6:Apexcal was placed in the apical half of root canal, the upper half of root canal and the pulp champer; Group 7: the control group without medication. 10 teeth of each group were placed in P.e suspension, the IL-6 and TNF-α expression of MC3T3-E1 was tested at 3 d and 7 d. The other teeth of each group were placed in distilled water, and the pH in periapical region was tested at 3, 7, 14 and 21 d. SPSS 13.0 software package was used for statistical analysis. RESULTS: Calcium hydroxide placed in different position of the root canal increased periapical pH value and reached its peak at 14 d. The group in which calcium hydroxide paste was placed in pulp chamber gained lower pH level than other experimental groups. IL-6, TNF-α expression of MC3T3-E1 pretreated by P.e suspension of experimental groups was significantly reduced compared with control group, and there was no significant difference between the experimental groups. CONCLUSIONS: Calcium hydroxide placed in different position of the root canal could increase periapical pH value and reduce IL- 6, TNF-α expression of periapical osteoblasts.
[Mh] Termos MeSH primário: Hidróxido de Cálcio/farmacologia
Interleucina-6/metabolismo
Osteoblastos/metabolismo
Tecido Periapical/metabolismo
Fator de Necrose Tumoral alfa/metabolismo
[Mh] Termos MeSH secundário: Polpa Dentária
Cavidade Pulpar
Seres Humanos
Materiais Restauradores do Canal Radicular
Tratamento do Canal Radicular
Raiz Dentária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ApexCal); 0 (Interleukin-6); 0 (Root Canal Filling Materials); 0 (Tumor Necrosis Factor-alpha); PF5DZW74VN (Calcium Hydroxide)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:160412
[St] Status:MEDLINE


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[PMID]:27059651
[Au] Autor:Cintra LT; Samuel RO; Azuma MM; de Queiróz AO; Ervolino E; Sumida DH; de Lima VM; Gomes-Filho JE
[Ad] Endereço:Department of Endodontics, Araçatuba Dental School, Universidade Estadual Paulista, Araçatuba, São Paulo, Brazil. Electronic address: lucianocintra@foa.unesp.br.
[Ti] Título:Multiple Apical Periodontitis Influences Serum Levels of Cytokines and Nitric Oxide.
[So] Source:J Endod;42(5):747-51, 2016 May.
[Is] ISSN:1878-3554
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: This study evaluated whether apical periodontitis (AP) in a single tooth or in multiple teeth affected serum levels of inflammatory mediators and influenced blood homeostasis. METHODS: Thirty male Wistar rats were divided into 3 groups of 10 rats each: control group, healthy rats; 1AP group, rats with AP in 1 tooth; and 4AP group, rats with AP in 4 teeth. After 30 days, the rats were anesthetized, and their blood was collected through cardiac puncture to quantify tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), interleukin (IL)-6, IL-17, IL-23, and nitric oxide (NO) levels. The rats were then sacrificed by administering an anesthetic overdose. Their maxillary and mandibular molars were collected and processed for histologic analysis with hematoxylin-eosin and for immunohistochemical staining of the cytokines and NO-producing enzyme nitric oxide synthase. Results of these analyses were statistically analyzed; P < .05 was considered statistically significant. RESULTS: Rats in the 1AP and 4AP groups showed increased IL-6, IL-17, IL-23, TNF-α, IFN-γ, and NO synthase expression; inflammatory cell infiltration; and moderate bone resorption in affected teeth. Serum TNF-α, IL-6, IL-17, and IL-23 levels were higher in rats in the 4AP group than in those in the control group (P < .05). Serum NO levels were significantly lower in rats in the 1AP and 4AP groups than in those in the control group (P < .05). Serum IFN-γ levels were not different among rats in the 3 groups (P > .05). CONCLUSIONS: These results suggested that AP affected blood homeostasis by altering the serum levels of inflammatory cytokines and NO.
[Mh] Termos MeSH primário: Citocinas/sangue
Óxido Nítrico/sangue
Periodontite Periapical/sangue
Periodontite Periapical/metabolismo
Soro/química
[Mh] Termos MeSH secundário: Animais
Reabsorção Óssea
Interferon gama/sangue
Interleucina-17
Interleucina-23
Interleucina-6
Masculino
Mandíbula
Maxila
Dente Molar
Periodontite Periapical/diagnóstico por imagem
Tecido Periapical/diagnóstico por imagem
Tecido Periapical/patologia
Ratos
Ratos Wistar
Fator de Necrose Tumoral alfa/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Interleukin-17); 0 (Interleukin-23); 0 (Interleukin-6); 0 (Tumor Necrosis Factor-alpha); 31C4KY9ESH (Nitric Oxide); 82115-62-6 (Interferon-gamma)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:160410
[St] Status:MEDLINE


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[PMID]:26949765
[Au] Autor:Gutmacher Z; Machtei EE; Hirsh I; Zigdon-Giladi H; Horwitz J
[Ti] Título:A comparative study on the use of digital panoramic and periapical radiographs to assess proximal bone height around dental implants.
[So] Source:Quintessence Int;47(5):441-6, 2016.
[Is] ISSN:1936-7163
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The purpose of this study was to compare periapical radiographs (PA) and panoramic radiographs (PAN) in the measurement of proximal bone height around implants. METHOD AND MATERIALS: Patients files that contained digital PAN and PA together with information on implant lengths and diameters were selected for this study. For each radiograph, the implant size served as reference for calibration. Proximal radiographic bone levels and the linear distance between the bone crest and implant shoulder were measured twice by one examiner. Paired t test was used to assess intra-examiner variability and differences between the two radiographic methods. Correlation was then assessed using Pearson correlation coefficient test. Significance level was determined at 5%. RESULTS: For the PAN measurements, the median mesial distances from bone crest to implant shoulder were 0.53 and 0.56 mm (first and second sets, P = .53). Likewise, for distal measurements these readings were 0.92 and 0.86 mm respectively (P = .66). For PA measurements, the corresponding measurements were 0.33 and 0.44 mm (P = .48) and 0.99 and 0.99 mm (P = .42), respectively. When PAN and PA measurements were compared, no statistically significant differences were detected between the two radiographic modalities. A very high positive correlation (r > 0.91) was attained for the PAN - PA measurements (P < .0001). CONCLUSION: PAN are potentially as reliable and reproducible as PA for the assessment of proximal bone height around dental implants.
[Mh] Termos MeSH primário: Perda do Osso Alveolar/diagnóstico por imagem
Implantes Dentários
Radiografia Panorâmica
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Masculino
Tecido Periapical/diagnóstico por imagem
Radiografia Dentária Digital
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dental Implants)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:160308
[St] Status:MEDLINE
[do] DOI:10.3290/j.qi.a35704



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