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[PMID]:29267675
[Au] Autor:Oliveira KV; Silva BMD; Leonardi DP; Crozeta BM; Sousa-Neto MD; Baratto-Filho F; Gabardo MCL
[Ad] Endereço:Universidade Positivo, Department of Dentistry, Curitiba, PR, Brazil.
[Ti] Título:Effectiveness of different final irrigation techniques and placement of endodontic sealer into dentinal tubules.
[So] Source:Braz Oral Res;31:e114, 2017 Dec 18.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to compare two irrigation techniques and four devices for endodontic sealer placement into the dentinal tubules. Ninety-nine single-rooted human teeth were instrumented and allocated to either the control (CO) (n=11) or experimental groups according to the irrigation method: syringe and NaveTip needle (NT) (n=44), and EndoActivator (EA) (n=44). These groups were subdivided according to sealer placement into K-File (KF), lentulo spiral (LS), Easy Clean (EC), and EndoActivator (EA) subgroups. Moreover, the distances of 5 mm and 2 mm from the apex were analyzed. The teeth were obturated with AH Plus and GuttaCore X3. Analyses were performed by scanning electron microscopy associated to cathodoluminescence. The percentage and maximum depth of sealer penetration were measured. Data were evaluated by three-way analysis of variance (ANOVA) and Games-Howell test (p<0.05). EA was superior to NT in percentage of sealer penetration. EC was significantly superior to EA (subgroup) for sealer penetration, and both improved the percentage of sealer penetration when compared to LS. Better sealer penetration was observed at the distance of 5 mm from the apex. Sealer penetration into the dentinal tubules was significantly improved by sonic irrigant activation.
[Mh] Termos MeSH primário: Dentina/efeitos dos fármacos
Materiais Restauradores do Canal Radicular/química
Irrigantes do Canal Radicular/química
Obturação do Canal Radicular/métodos
Preparo de Canal Radicular/métodos
Irrigação Terapêutica/métodos
[Mh] Termos MeSH secundário: Análise de Variância
Cavidade Pulpar/efeitos dos fármacos
Cavidade Pulpar/ultraestrutura
Dentina/ultraestrutura
Resinas Epóxi/química
Resinas Epóxi/uso terapêutico
Seres Humanos
Teste de Materiais
Microscopia Confocal
Microscopia Eletrônica de Varredura
Reprodutibilidade dos Testes
Rodaminas
Materiais Restauradores do Canal Radicular/uso terapêutico
Irrigantes do Canal Radicular/uso terapêutico
Obturação do Canal Radicular/instrumentação
Preparo de Canal Radicular/instrumentação
Irrigação Terapêutica/instrumentação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Epoxy Resins); 0 (Rhodamines); 0 (Root Canal Filling Materials); 0 (Root Canal Irrigants); 0 (epoxy resin-based root canal sealer); BA7THR07HH (rhodamine isothiocyanate)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


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[PMID]:29267670
[Au] Autor:Bellan MC; Cunha PFJSD; Tavares JG; Spohr AM; Mota EG
[Ad] Endereço:Pontifícia Universidade Católica da Universidade Federal do Rio Grande do Sul - PUC-RS, School of Dentistry, Graduate Program, Porto Alegre, RS, Brazil.
[Ti] Título:Microtensile bond strength of CAD/CAM materials to dentin under different adhesive strategies.
[So] Source:Braz Oral Res;31:e109, 2017 Dec 18.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The present study aimed to evaluate the microtensile bond strength (µTBS) of novel computer-aided design/computer-aided manufacturing (CAD/CAM) restorative materials to dentin using different adhesive strategies. Thirty-two crowns were milled using CAD/CAM materials (Vita Mark II as control, Vita Suprinity, Vita Enamic and Lava Ultimate) and luted to dentin using different resin cements (RelyX ARC, RelyX Unicem 2 and RelyX Ultimate). The specimens were stored in 100% relative humidity at 37°C for 24 h and sectioned. The samples (n = 16) with cross-sectional areas of approximately 0.90 mm2, were submitted to a µTBS test in a universal testing machine with a crosshead speed of 0.5 mm/min. The samples were analyzed with SEM to determinate the failure mode. According to 2-way ANOVA and Tukey's test (α=0.05), the interaction effect (material x luting strategy) was significant (p=0.001). Regardless of the luting strategy, a higher µTBS was obtained with Lava Ultimate and Vita Enamic, which were significantly different from Vita Mark II and Vita Suprinity (p<0.05). For Vita Mark II, Vita Suprinity, Vita Enamic, and Lava Ultimate, the µTBS obtained with RelyX Unicem 2 was not significantly different from that obtained with RelyX ARC or RelyX Ultimate. All groups obtained at least three types of failure. The adhesive strategy with self-adhesive resin cement was comparable to conventional resin cement with total-etch or self-etch adhesive techniques in the bond of novel CAD/CAM materials to dentin.
[Mh] Termos MeSH primário: Cerâmica/química
Projeto Auxiliado por Computador
Colagem Dentária/métodos
Dentina/efeitos dos fármacos
Cimentos de Resina/química
[Mh] Termos MeSH secundário: Análise de Variância
Falha de Restauração Dentária
Dentina/química
Seres Humanos
Teste de Materiais
Microscopia Eletrônica de Varredura
Reprodutibilidade dos Testes
Propriedades de Superfície/efeitos dos fármacos
Resistência à Tração
Fatores de Tempo
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Resin Cements)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


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[PMID]:29412223
[Au] Autor:Genari B; Leitune VCB; Jornada DS; Aldrigui BR; Pohlmann AR; Guterres SS; Samuel SMW; Collares FM
[Ad] Endereço:Universidade Federal do Rio Grande do Sul - UFRGS, School of Dentistry, Dental Materials Laboratory, Porto Alegre, RS, Brazil.
[Ti] Título:Effect on adhesion of a nanocapsules-loaded adhesive system.
[So] Source:Braz Oral Res;32:e008, 2018 Feb 01.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:This study aimed to evaluate the in situ degree of conversion, contact angle, and immediate and long-term bond strengths of a commercial primer and an experimental adhesive containing indomethacin- and triclosan-loaded nanocapsules (NCs). The indomethacin- and triclosan-loaded NCs, which promote anti-inflammatory and antibacterial effects through controlled release, were incorporated into the primer at a concentration of 2% and in the adhesive at concentrations of 1, 2, 5, and 10%. The in situ degree of conversion (DC, n=3) was evaluated by micro-Raman spectroscopy. The contact angle of the primer and adhesive on the dentin surface (n = 3) was determined by an optical tensiometer. For the microtensile bond strength µTBS test (12 teeth per group), stick-shaped specimens were tested under tensile stress immediately after preparation and after storage in water for 1 year. The data were analyzed using two-way ANOVA, three-way ANOVA and Tukey's post hoc tests with α=0.05. The use of the NC-loaded adhesive resulted in a higher in situ degree of conversion. The DC values varied from 75.07 ± 8.83% to 96.18 ± 0.87%. The use of NCs in only the adhesive up to a concentration of 5% had no influence on the bond strength. The contact angle of the primer remained the same with and without NCs. The use of both the primer and adhesive with NCs (for all concentrations) resulted in a higher contact angle of the adhesive. The longitudinal µTBS was inversely proportional to the concentration of NCs in the adhesive system, exhibiting decreasing values for the groups with primer containing NCs and adhesives with increasing concentrations of NCs. Adhesives containing up to 5% of nanocapsules and primer with no NCs maintained the in situ degree of conversion, contact angle, and immediate and long-term bond strengths. Therefore, the NC-loaded adhesive can be an alternative method for combining the bond performance and therapeutic effects. The use of an adhesive with up to 5% nanocapsules containing indomethacin and triclosan and a primer with no nanocapsules maintained the long-term bond performance.
[Mh] Termos MeSH primário: Colagem Dentária/métodos
Indometacina/química
Nanocápsulas/química
Cimentos de Resina/química
Triclosan/química
[Mh] Termos MeSH secundário: Análise de Variância
Animais
Bovinos
Falha de Restauração Dentária
Dentina/efeitos dos fármacos
Teste de Materiais
Transição de Fase/efeitos dos fármacos
Polimerização/efeitos dos fármacos
Valores de Referência
Reprodutibilidade dos Testes
Análise Espectral Raman
Propriedades de Superfície/efeitos dos fármacos
Resistência à Tração
Fatores de Tempo
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nanocapsules); 0 (Resin Cements); 4NM5039Y5X (Triclosan); 90881-69-9 (Scotchbond); XXE1CET956 (Indomethacin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:180208
[St] Status:MEDLINE


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[PMID]:29340524
[Au] Autor:Baraba A; Kqiku L; Gabric D; Verzak Z; Hanscho K; Miletic I
[Ad] Endereço:Department of Endodontics and Restorative Dentistry, School of Dental Medicine, University of Zagreb, Zagreb, Croatia.
[Ti] Título:Efficacy of removal of cariogenic bacteria and carious dentin by ablation using different modes of Er:YAG lasers.
[So] Source:Braz J Med Biol Res;51(3):e6872, 2018 Jan 11.
[Is] ISSN:1414-431X
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The primary objective of this in vitro study was to evaluate the efficiency of removal of cariogenic bacteria and carious dentin by ablation using two lasers: fluorescence-feedback controlled (FFC) Er:YAG laser and different pulses of Er:YAG laser based on variable square pulse technology (VSPt). The secondary objective was to measure the temperature during laser ablation of carious tissue. Seventy-two extracted human molars were used in this study. Sixty teeth with carious dentin were randomly divided into four experimental groups according to the treatment for caries removal: group 1: 400 µs (FFC group); group 2: super short pulse (SSP group, 50 µs pulse); group 3: medium short pulse (MSP group, 100 µs pulse); group 4: short pulse (SP group, 300 µs pulse) and one positive control group with no treatment. Twelve teeth without carious lesion were used as a negative control group. After caries removal, swabs were taken with cotton pellets and real-time PCR analysis was performed. During caries ablation, a thermal infrared camera was used to measure the temperature changes. In all experimental groups, specimens were free of bacterial contamination after the treatment. In the SSP, MSP and SP groups, temperatures measured during caries ablation were significantly higher compared to temperatures in the FFC group (P<0.001). In this in vitro study, laser treatment for removal of carious dentin and cariogenic bacteria was an efficient treatment modality without causing excessive temperatures that might adversely affect pulp vitality.
[Mh] Termos MeSH primário: Bactérias/isolamento & purificação
Cárie Dentária/terapia
Preparo da Cavidade Dentária/métodos
Dentina/microbiologia
Lasers de Estado Sólido/uso terapêutico
[Mh] Termos MeSH secundário: Cárie Dentária/diagnóstico
Polpa Dentária/fisiologia
Bactérias Gram-Negativas/isolamento & purificação
Bactérias Gram-Positivas/isolamento & purificação
Seres Humanos
Raios Infravermelhos
Reação em Cadeia da Polimerase em Tempo Real
Temperatura Ambiente
Termografia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE


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[PMID]:29211291
[Au] Autor:Rocha FRG; Souza JAC; Guimarães-Stabili MR; Sampaio JEC; Rossa C
[Ad] Endereço:University of Florida at Gainesville, Department of Oral Biology and Periodontology, Gainesville, USA.
[Ti] Título:Topical application of bFGF on acid-conditioned and non-conditioned dentin: effect on cell proliferation and gene expression in cells relevant for periodontal regeneration.
[So] Source:J Appl Oral Sci;25(6):689-699, 2017 Nov-Dec.
[Is] ISSN:1678-7765
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:MATERIAL AND METHODS: Periodontal regeneration is still a challenge in terms of predictability and magnitude of effect. In this study we assess the biological effects of combining chemical root conditioning and biological mediators on three relevant cell types for periodontal regeneration. Bovine dentin slices were conditioned with 25% citric acid followed by topical application of basic fibroblast growth factor (bFGF, 10 and 50 ng). We used ELISA to assess the dynamics of bFGF release from the dentin surface and RT-qPCR to study the expression of Runx2, Col1a1, Bglap and fibronectin by periodontal ligament (PDL) fibroblasts, cementoblasts and bone marrow stromal cells (BMSC) grown onto these dentin slices. We also assessed the effects of topical application of bFGF on cell proliferation by quantification of genomic DNA. RESULTS: Acid conditioning significantly increased the release of bFGF from dentin slices. Overall, bFGF application significantly (p<0.05) increased cell proliferation, except for BMSC grown on non-conditioned dentin slices. Dentin substrate discretely increased expression of Col1a1 in all cell types. Expression of Runx2, Col1a1 and Fn was either unaffected or inhibited by bFGF application in all cell types. We could not detect expression of the target genes on BMSC grown onto conditioned dentin. CONCLUSION: Acid conditioning of dentin improves the release of topically-applied bFGF. Topical application of bFGF had a stimulatory effect on proliferation of PDL fibroblasts, cementoblasts and BMSC, but did not affect expression of Runx2, Col1a1, Bglap and fibronectin by these cells.
[Mh] Termos MeSH primário: Proliferação Celular/efeitos dos fármacos
Dentina/efeitos dos fármacos
Fator 2 de Crescimento de Fibroblastos/farmacologia
Ligamento Periodontal/efeitos dos fármacos
Regeneração/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Bovinos
Fator 2 de Crescimento de Fibroblastos/administração & dosagem
Expressão Gênica
Ligamento Periodontal/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
103107-01-3 (Fibroblast Growth Factor 2)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


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[PMID]:29370163
[Au] Autor:Loison-Robert LS; Tassin M; Bonte E; Berbar T; Isaac J; Berdal A; Simon S; Fournier BPJ
[Ad] Endereço:School of Dentistry, Paris Descartes University, Sorbonne Paris Cité, Paris, France.
[Ti] Título:In vitro effects of two silicate-based materials, Biodentine and BioRoot RCS, on dental pulp stem cells in models of reactionary and reparative dentinogenesis.
[So] Source:PLoS One;13(1):e0190014, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Calcium silicate-based cements are biomaterials with calcium oxide and carbonate filler additives. Their properties are close to those of dentin, making them useful in restorative dentistry and endodontics. The aim of this study was to evaluate the in vitro biological effects of two such calcium silicate cements, Biodentine (BD) and Bioroot (BR), on dental stem cells in both direct and indirect contact models. The two models used aimed to mimic reparative dentin formation (direct contact) and reactionary dentin formation (indirect contact). An original aspect of this study is the use of an interposed thin agarose gel layer to assess the effects of diffusible components from the materials. RESULTS: The two biomaterials were compared and did not modify dental pulp stem cell (DPSC) proliferation. BD and BR showed no significant cytotoxicity, although some cell death occurred in direct contact. No apoptosis or inflammation induction was detected. A striking increase of mineralization induction was observed in the presence of BD and BR, and this effect was greater in direct contact. Surprisingly, biomineralization occurred even in the absence of mineralization medium. This differentiation was accompanied by expression of odontoblast-associated genes. Exposure by indirect contact did not stimulate the induction to such a level. CONCLUSION: These two biomaterials both seem to be bioactive and biocompatible, preserving DPSC proliferation, migration and adhesion. The observed strong mineralization induction through direct contact highlights the potential of these biomaterials for clinical application in dentin-pulp complex regeneration.
[Mh] Termos MeSH primário: Materiais Dentários
Polpa Dentária/efeitos dos fármacos
Dentina/efeitos dos fármacos
Silicatos/farmacologia
Células-Tronco/efeitos dos fármacos
[Mh] Termos MeSH secundário: Materiais Biocompatíveis
Proliferação Celular/efeitos dos fármacos
Citoesqueleto/efeitos dos fármacos
Polpa Dentária/citologia
Polpa Dentária/metabolismo
Matriz Extracelular/efeitos dos fármacos
Seres Humanos
Concentração de Íons de Hidrogênio
Técnicas In Vitro
Microscopia Eletrônica de Varredura
Modelos Biológicos
Estresse Oxidativo/efeitos dos fármacos
RNA Mensageiro/metabolismo
Reação em Cadeia da Polimerase em Tempo Real
Células-Tronco/citologia
Células-Tronco/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biocompatible Materials); 0 (Dental Materials); 0 (RNA, Messenger); 0 (Silicates)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190014


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[PMID]:29338011
[Au] Autor:Waugh DA; Suydam RS; Ortiz JD; Thewissen JGM
[Ad] Endereço:Department of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, Ohio, United States of America.
[Ti] Título:Validation of Growth Layer Group (GLG) depositional rate using daily incremental growth lines in the dentin of beluga (Delphinapterus leucas (Pallas, 1776)) teeth.
[So] Source:PLoS One;13(1):e0190498, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Counts of Growth Layer Groups (GLGs) in the dentin of marine mammal teeth are widely used as indicators of age. In most marine mammals, observations document that GLGs are deposited yearly, but in beluga whales, some studies have supported the view that two GLGs are deposited each year. Our understanding of beluga life-history differs substantially depending on assumptions regarding the timing of GLG deposition; therefore, resolving this issue has important considerations for population assessments. In this study, we used incremental lines that represent daily pulses of dentin mineralization to test the hypothesis that GLGs in beluga dentin are deposited on a yearly basis. Our estimate of the number of daily growth lines within one GLG is remarkably close to 365 days within error, supporting the hypothesis that GLGs are deposited annually in beluga. We show that measurement of daily growth increments can be used to validate the time represented by GLGs in beluga. Furthermore, we believe this methodology may have broader applications to age estimation in other taxa.
[Mh] Termos MeSH primário: Beluga
Dentina/crescimento & desenvolvimento
Dente/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Animais
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; VALIDATION STUDIES
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180117
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190498


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[PMID]:29337060
[Au] Autor:Ota MS; Kondo K; Li Y; Iseki S; Yamashita A; Gibson CW; Kondo T
[Ad] Endereço:Laboratory of Anatomy, Physiology and Food Biological Science, Department of Food and Nutrition, Japan Women's University, Bunkyo-ku, Tokyo, Japan; Section of Molecular Craniofacial Embryology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan. Electro
[Ti] Título:Amelogenin X impacts age-dependent increase of frequency and number in labial incisor grooves in C57BL/6.
[So] Source:Biochem Biophys Res Commun;496(2):324-327, 2018 02 05.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Labial grooves in maxillary incisors have been reported in several wild-type rodent species. Previous studies have reported age-dependent labial grooves occur in moderate prevalence in C57BL/6 mice; however, very little is known about the occurrence of such grooves. In the present study, we observed age-dependent groove formation in C57BL/6 mice up to 26 months after birth and found that not only the frequency of the appearance of incisor grooves but also the number of grooves increased in an age-dependent manner. We examined the molecular mechanisms of age-dependent groove formation by performing DNA microarray analysis of the incisors of 12-month-old (12M) and 24-month-old (24M) mice. Amelx, encoding the major enamel matrix protein AMELOGENIN, was identified as a 12M-specific gene. Comparing with wild-type mice, the maxillary incisors of Amelx mutants indicated the increase of the frequency and number of labial grooves. These findings suggested that the Amelx gene impacts the age-dependent appearance of the labial incisor groove in C57BL/6 mice.
[Mh] Termos MeSH primário: Envelhecimento/genética
Amelogenina/genética
Esmalte Dentário/metabolismo
Dentina/metabolismo
Regulação da Expressão Gênica no Desenvolvimento
Incisivo/metabolismo
[Mh] Termos MeSH secundário: Envelhecimento/metabolismo
Envelhecimento/patologia
Amelogenina/deficiência
Animais
Esmalte Dentário/diagnóstico por imagem
Esmalte Dentário/patologia
Dentina/diagnóstico por imagem
Dentina/patologia
Incisivo/diagnóstico por imagem
Incisivo/patologia
Maxila/diagnóstico por imagem
Maxila/metabolismo
Maxila/patologia
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Análise de Sequência com Séries de Oligonucleotídeos
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Amelogenin); 0 (Amelx protein, mouse)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180117
[St] Status:MEDLINE


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[PMID]:28465067
[Au] Autor:Mahdhaoui K; Fournier B; Derbanne MA
[Ad] Endereço:Unité de Recherche en Biomatériaux Innovants et Interfaces (URB2I)-EA4462, Faculté de Chirurgie Dentaire, Université Paris Descartes, Sorbonne Paris Cité, 1 rue Maurice Arnoux, 92120 Montrouge, France.
[Ti] Título:Unbound monomers do diffuse through the dentin barrier.
[So] Source:Dent Mater;33(6):743-751, 2017 06.
[Is] ISSN:1879-0097
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Assessing the role of dentinal fluid proteins in trans-dentinal diffusion of free monomers in vitro. METHODS: An artificial pulp chamber (APC) topped human dentin disks was used. A simplified two-step etch-and-rinse adhesive was formulated with 2-hydroethyl-methacrylate (HEMA), Bisphenol-A-diglycidyl-methacrylate (BisGMA), using Camphorquinone/tertiary amine as initiators. Two extraction media were used: buffered saline (Control), buffered saline with 1% bovine serum albumin (BSA). Samples were acid-etched, rinsed, air dried. Simplified primer was used, adhesive applied then light cured with a LED curing. Monomer diffusion was assessed by reverse phase HPLC. RESULTS: Quantifiable amounts of HEMA were detected in both extraction media while BisGMA was present in quantifiable amounts in BSA medium only. Diffused monomers concentrations were significantly higher for both monomers in BSA extraction medium. SIGNIFICANCE: Albumin is sometimes referred to as taxi protein for its ability to bind and transport hydrophobic ligands. From our results, we hypothesized that albumin can also transport unbound monomers released from dental adhesive through the dentin barrier. However, dentinal fluid proteins like albumin could have significant effect on monomer diffusion through dentin to the dental pulp transporting highly hydrophobic molecules like BisGMA and enhancing diffusion of more hydrophilic ones like HEMA. These results demonstrate a new possible mechanism for cytotoxicity of resin monomers.
[Mh] Termos MeSH primário: Albuminas/fisiologia
Bis-Fenol A-Glicidil Metacrilato
Cimentos Dentários
Adesivos Dentinários/farmacocinética
Dentina/metabolismo
Cimentos de Resina/farmacocinética
[Mh] Termos MeSH secundário: Ataque Ácido Dentário
Colagem Dentária
Seres Humanos
Metacrilatos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Albumins); 0 (Dental Cements); 0 (Dentin-Bonding Agents); 0 (Methacrylates); 0 (Resin Cements); 454I75YXY0 (Bisphenol A-Glycidyl Methacrylate)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE


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[PMID]:28449922
[Au] Autor:Genari B; Leitune VCB; Jornada DS; Camassola M; Arthur RA; Pohlmann AR; Guterres SS; Collares FM; Samuel SMW
[Ad] Endereço:Dental Materials Laboratory, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: bruna.genari@ufrgs.br.
[Ti] Título:Antimicrobial effect and physicochemical properties of an adhesive system containing nanocapsules.
[So] Source:Dent Mater;33(6):735-742, 2017 06.
[Is] ISSN:1879-0097
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To incorporate indomethacin and triclosan-loaded nanocapsules into primer and adhesive, and evaluate its properties. METHODS: Indomethacin and triclosan were encapsulated by deposition of preformed polymer and subsequently characterized regarding morphology, particle size, drug content and cytotoxicity. Nanocapsules (NCs) were incorporated into primer at 2% and into adhesive at 1, 2, 5, and 10% concentrations. Degree of conversion (DC) and softening in ethanol of the adhesive were evaluated. Drug release and drug diffusion through dentin was quantified by high performance liquid chromatography. Antimicrobial test was performed until 96h. RESULTS: Spherical and biocompatible NCs presented mean size of 159nm. Drugs content was 3mg indomethacin/g powder and 2mg triclosan/g powder. Incorporating NCs in adhesive showed no influence in DC (p=0.335). The addition of 2% of NCs showed no influence in softening in ethanol (p>0.05). After 120h, 93% of indomethacin and 80% of triclosan were released from primer, 20% of indomethacin and 17% of triclosan were released from adhesive with 10% of NCs. Indomethacin showed diffusion through dentin. In 24h, adhesive containing 2 and 5% of NCs using primer with NCs showed antimicrobial effect. In 96h, adhesives containing different concentration of NCs promoted antimicrobial effect. CONCLUSIONS: Indomethacin and triclosan-loaded nanocapsules were successfully incorporated into primer and adhesive, promoting controlled drugs release, indomethacin diffusion through dentin and antimicrobial effect without compromising its physicochemical properties. SIGNIFICANCE: Indomethacin and triclosan-loaded nanocapsules have potential to prevent recurrent caries and to be used in deep cavities controlling pulpar inflammatory process.
[Mh] Termos MeSH primário: Anti-Infecciosos
Cimentos Dentários
Nanocápsulas
[Mh] Termos MeSH secundário: Dentina
Indometacina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Dental Cements); 0 (Nanocapsules); XXE1CET956 (Indomethacin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE



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