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  1 / 15416 MEDLINE  
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[PMID]:29412559
[Au] Autor:Chesnokova LA; Mikhaylova IV; Voronkova IP; Karmanova DS
[Ti] Título:[Experimental evaluation of the impact of low doses of the herbicide 2,4-D in drinking water on some indices of lipid and immune status].
[So] Source:Gig Sanit;95(5):450-54, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:There were studied features of the manifestation of incoming with potable water nontoxic doses of the herbicide 2,4-D on the body mass index, some indices of lipid metabolism and immune system in different types of diets in the experiment in rats. There was shown a significant gain in body weight of animals, and MDA and leptin level in the serum under the action of a herbicide in conjunction with a high-calorie diet. In all experimental groups there was noted the increased level of total cholesterol, tendency to the increase of LDL cholesterol. Under the action of the herbicide there was noted an increase of IL-6, TNF-a and the numbers of leukocytes and, on the contrary, the reduction of the number of thymocytes and kariocytes in thymus and spleen.
[Mh] Termos MeSH primário: Ácido 2,4-Diclorofenoxiacético
Água Potável
Sistema Imunitário/efeitos dos fármacos
Metabolismo dos Lipídeos/efeitos dos fármacos
[Mh] Termos MeSH secundário: Ácido 2,4-Diclorofenoxiacético/efeitos adversos
Ácido 2,4-Diclorofenoxiacético/análise
Animais
Relação Dose-Resposta a Droga
Água Potável/efeitos adversos
Água Potável/análise
Herbicidas/efeitos adversos
Herbicidas/análise
Masculino
Modelos Animais
Ratos
Ratos Wistar
Poluentes Químicos da Água/efeitos adversos
Poluentes Químicos da Água/antagonistas & inibidores
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drinking Water); 0 (Herbicides); 0 (Water Pollutants, Chemical); 2577AQ9262 (2,4-Dichlorophenoxyacetic Acid)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180208
[St] Status:MEDLINE


  2 / 15416 MEDLINE  
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[PMID]:29385145
[Au] Autor:Zheng Q; Shen J; Wang Z
[Ad] Endereço:College of Information Science and Technology, Donghua University, Shanghai, Shanghai, China.
[Ti] Título:Pattern dynamics of the reaction-diffusion immune system.
[So] Source:PLoS One;13(1):e0190176, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this paper, we will investigate the effect of diffusion, which is ubiquitous in nature, on the immune system using a reaction-diffusion model in order to understand the dynamical behavior of complex patterns and control the dynamics of different patterns. Through control theory and linear stability analysis of local equilibrium, we obtain the optimal condition under which the system loses stability and a Turing pattern occurs. By combining mathematical analysis and numerical simulation, we show the possible patterns and how these patterns evolve. In addition, we establish a bridge between the complex patterns and the biological mechanism using the results from a previous study in Nature Cell Biology. The results in this paper can help us better understand the biological significance of the immune system.
[Mh] Termos MeSH primário: Sistema Imunitário/fisiologia
[Mh] Termos MeSH secundário: Animais
Modelos Teóricos
Neoplasias/imunologia
Neoplasias/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190176


  3 / 15416 MEDLINE  
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[PMID]:29187113
[Au] Autor:Kumar SR
[Ad] Endereço:1 Division of Cardiac Surgery, Department of Surgery, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.
[Ti] Título:Immune System in Single Ventricle Patients-A Complex Nexus.
[So] Source:World J Pediatr Congenit Heart Surg;8(6):683-684, 2017 11.
[Is] ISSN:2150-136X
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Técnica de Fontan
Ventrículos do Coração/cirurgia
[Mh] Termos MeSH secundário: Anormalidades Cardiovasculares
Cardiopatias Congênitas
Seres Humanos
Sistema Imunitário
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1177/2150135117739830


  4 / 15416 MEDLINE  
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[PMID]:29188697
[Au] Autor:Scully C; Georgakopoulou EA; Hassona Y
[Ti] Título:The Immune System: Basis of so much Health and Disease: 4. Immunocytes.
[So] Source:Dent Update;44(5):436-8, 441-2, 2017 May.
[Is] ISSN:0305-5000
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The immune system is the body's primary defence mechanism against infections, and disturbances in the system can cause disease if the system fails in defence functions (in immunocompromised people), or if the activity is detrimental to the host (as in auto-immune and auto-inflammatory states). A healthy immune system is also essential to normal health of dental and oral tissues. This series presents the basics for the understanding of the immune system, this article covers cells of the immune system (immunocytes). Clinical relevance: Modern dental clinicians need a basic understanding of the immune system as it underlies health and disease.
[Mh] Termos MeSH primário: Sistema Imunitário/citologia
Sistema Imunitário/imunologia
[Mh] Termos MeSH secundário: Seres Humanos
Imunidade/fisiologia
Linfócitos/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE


  5 / 15416 MEDLINE  
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[PMID]:29172358
[Au] Autor:Scully; Georgakopoulou EA; Hassona Y
[Ti] Título:The Immune System: Basis of so much Health and Disease: 3. Adaptive Immunity.
[So] Source:Dent Update;44(4):322-4, 327, 2017 Apr.
[Is] ISSN:0305-5000
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The immune system is the body's primary defence mechanism against infections, and disturbances in the system can cause disease if the system fails in defence functions (in immunocompromised people), or if the activity is detrimental to the host (as in auto-immune and auto-inflammatory states). A healthy immune system is also essential to normal health of dental and oral tissues. This series presents the basics for the understanding of the immune system; this article covers adaptive immunity. Clinical relevance: Dental clinicians need a basic understanding of the immune system as it underlies health and disease.
[Mh] Termos MeSH primário: Imunidade Adaptativa/imunologia
Sistema Imunitário/imunologia
[Mh] Termos MeSH secundário: Seres Humanos
Imunidade/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


  6 / 15416 MEDLINE  
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[PMID]:28465358
[Au] Autor:Amankulor NM; Kim Y; Arora S; Kargl J; Szulzewsky F; Hanke M; Margineantu DH; Rao A; Bolouri H; Delrow J; Hockenbery D; Houghton AM; Holland EC
[Ad] Endereço:Department of Neurosurgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.
[Ti] Título:Mutant IDH1 regulates the tumor-associated immune system in gliomas.
[So] Source:Genes Dev;31(8):774-786, 2017 04 15.
[Is] ISSN:1549-5477
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Gliomas harboring mutations in isocitrate dehydrogenase 1/2 (IDH1/2) have the CpG island methylator phenotype (CIMP) and significantly longer patient survival time than wild-type IDH1/2 (wtIDH1/2) tumors. Although there are many factors underlying the differences in survival between these two tumor types, immune-related differences in cell content are potentially important contributors. In order to investigate the role of IDH mutations in immune response, we created a syngeneic pair mouse model for mutant IDH1 (muIDH1) and wtIDH1 gliomas and demonstrated that muIDH1 mice showed many molecular and clinical similarities to muIDH1 human gliomas, including a 100-fold higher concentration of 2-hydroxygluratate (2-HG), longer survival time, and higher CpG methylation compared with wtIDH1. Also, we showed that IDH1 mutations caused down-regulation of leukocyte chemotaxis, resulting in repression of the tumor-associated immune system. Given that significant infiltration of immune cells such as macrophages, microglia, monocytes, and neutrophils is linked to poor prognosis in many cancer types, these reduced immune infiltrates in muIDH1 glioma tumors may contribute in part to the differences in aggressiveness of the two glioma types.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/genética
Neoplasias Encefálicas/imunologia
Glioma/genética
Glioma/imunologia
Sistema Imunitário/fisiopatologia
Isocitrato Desidrogenase/genética
Isocitrato Desidrogenase/metabolismo
[Mh] Termos MeSH secundário: Animais
Neoplasias Encefálicas/enzimologia
Quimiotaxia/genética
Metilação de DNA
Modelos Animais de Doenças
Glioma/enzimologia
Seres Humanos
Antígenos Comuns de Leucócito/metabolismo
Leucócitos/patologia
Camundongos
Mutação
Infiltração de Neutrófilos/genética
Neutrófilos/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
EC 1.1.1.41 (Isocitrate Dehydrogenase); EC 3.1.3.48 (Leukocyte Common Antigens)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1101/gad.294991.116


  7 / 15416 MEDLINE  
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[PMID]:28452951
[Au] Autor:Hang B; Wang P; Zhao Y; Sarker A; Chenna A; Xia Y; Snijders AM; Mao JH
[Ad] Endereço:Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. bo_hang@lbl.gov.
[Ti] Título:Adverse Health Effects of Thirdhand Smoke: From Cell to Animal Models.
[So] Source:Int J Mol Sci;18(5), 2017 Apr 28.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The newly identified smoke hazard, thirdhand smoke (THS), has gained public attention in recent years but its health impact and biological effects are largely unknown. THS may be defined by "the four Rs": tobacco chemicals that remain, react, re-emit, and/or are resuspended long after active smoking has ceased. This review summarizes recent research progress in the effects of THS on genotoxicity, metabolism and early life development using cellular and animal models. We first reported that THS generated in laboratory systems caused significant DNA damage in human cell lines. Our finding that THS significantly induces oxidative base lesions has been confirmed in skin wounds of mice models exposed to THS. THS also induced metabolomic changes in human reproductive cell lines. Furthermore, we demonstrated that early exposure to THS not only negatively impacts body weight in both male and female mice, but also induces persistent changes to immunological parameters in peripheral blood in these mice. These results indicate that THS is genotoxic at realistic experimental doses and that there may be a window of susceptibility for some forms of cellular damage induced by THS.
[Mh] Termos MeSH primário: Poluição por Fumaça de Tabaco
[Mh] Termos MeSH secundário: Poluentes Atmosféricos/toxicidade
Animais
Apoptose/efeitos dos fármacos
Adutos de DNA/química
Adutos de DNA/metabolismo
Dano ao DNA/efeitos dos fármacos
Seres Humanos
Sistema Imunitário/efeitos dos fármacos
Sistema Imunitário/metabolismo
Modelos Animais
Reprodução/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Air Pollutants); 0 (DNA Adducts); 0 (Tobacco Smoke Pollution)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


  8 / 15416 MEDLINE  
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[PMID]:29238017
[Au] Autor:Nakane S; Mukaino A; Ando Y
[Ad] Endereço:Department of Neurology, Graduate School of Medical Sciences, Kumamoto University.
[Ti] Título:[The interface between the immune system and autonomic nervous system].
[So] Source:Nihon Rinsho Meneki Gakkai Kaishi;40(5):352-360, 2017.
[Is] ISSN:1349-7413
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:  The nervous system and the immune system are two major systems in human body. Although it was revealed these two systems correlated, the control of immune cell dynamics by the nervous system has come to draw a lot of attention at the present time. Recent advances in basic and preclinical science reveal that reflex neural circuits inhibit the production of cytokines and inflammation in several animal models. One well-characterized cytokine-inhibiting mechanism, termed the "inflammatory reflex", is dependent upon vagus nerve stimulation that inhibits cytokine production and attenuates the inflammation. And the mechanism for controlling lymphocyte trafficking becomes clear, and molecular basis of immune regulation by the nervous system was reported. On the other hand, the nervous system is protected from the invasion of harmful agents by the barrier. However, there are neuroimmunological disorders, which is associated with autoimmunity, tumor immunity, and infection immunity. Autoimmune autonomic ganglionopathy (AAG) is an acquired immune-mediated disorder that leads to widespread autonomic manifestations, in which autoantibodies to ganglionic nicotinic acetylcholine receptors play a central role. Previously, we elucidated the prevalence of extra-autonomic manifestations in patients with AAG. It is necessary to establish the new systems for the detection of autoantibodies to other subunits of acetylcholine receptor.
[Mh] Termos MeSH primário: Sistema Nervoso Autônomo/imunologia
Sistema Imunitário/imunologia
Inflamação/imunologia
[Mh] Termos MeSH secundário: Animais
Autoanticorpos/imunologia
Autoimunidade/imunologia
Citocinas/imunologia
Citocinas/metabolismo
Gânglios Autônomos/imunologia
Seres Humanos
Neuroimunomodulação/imunologia
Receptores Colinérgicos/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Autoantibodies); 0 (Cytokines); 0 (Receptors, Cholinergic)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.2177/jsci.40.352


  9 / 15416 MEDLINE  
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[PMID]:29213157
[Au] Autor:Rangel-Sosa MM; Aguilar-Córdova E; Rojas-Martínez A
[Ad] Endereço:Departamento de Bioquímica y Medicina Molecular, Facultad de Medicina, Universidad Autónoma de Nuevo León. Nuevo León, México.
[Ti] Título:Immunotherapy and gene therapy as novel treatments for cancer.
[So] Source:Colomb Med (Cali);48(3):138-147, 2017 Sep 30.
[Is] ISSN:1657-9534
[Cp] País de publicação:Colombia
[La] Idioma:eng
[Ab] Resumo:The immune system interacts closely with tumors during the disease development and progression to metastasis. The complex communication between the immune system and the tumor cells can prevent or promote tumor growth. New therapeutic approaches harnessing protective immunological mechanisms have recently shown very promising results. This is performed by blocking inhibitory signals or by activating immunological effector cells directly. Immune checkpoint blockade with monoclonal antibodies directed against the inhibitory immune receptors CTLA-4 and PD-1 has emerged as a successful treatment approach for patients with advanced melanoma. Ipilimumab is an anti-CTLA-4 antibody which demonstrated good results when administered to patients with melanoma. Gene therapy has also shown promising results in clinical trials. Particularly, virus (HSV)-mediated delivery of the HSV thymidine kinase (TK) gene to tumor cells in combination with ganciclovir (GCV) may provide an effective suicide gene therapy for destruction of glioblastomas, prostate tumors and other neoplasias by recruiting tumor-infiltrating lymphocytes into the tumor. The development of new treatment strategies or combination of available innovative therapies to improve cell cytotoxic T lymphocytes trafficking into the tumor mass and the production of inhibitory molecules blocking tumor tissue immune-tolerance are crucial to improve the efficacy of cancer therapy.
[Mh] Termos MeSH primário: Terapia Genética/métodos
Imunoterapia/métodos
Neoplasias/terapia
[Mh] Termos MeSH secundário: Antígeno CTLA-4
Terapia Combinada/métodos
Seres Humanos
Sistema Imunitário
Imunidade Celular
Neoplasias/imunologia
Receptor de Morte Celular Programada 1/metabolismo
Linfócitos T Reguladores/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (CTLA-4 Antigen); 0 (PDCD1 protein, human); 0 (Programmed Cell Death 1 Receptor)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180109
[Lr] Data última revisão:
180109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.25100/cm.v48i3.2997


  10 / 15416 MEDLINE  
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[PMID]:29253870
[Au] Autor:Sasidhar MV; Chevooru SK; Eickelberg O; Hartung HP; Neuhaus O
[Ad] Endereço:Department of Neurology, Heinrich Heine University, Düsseldorf, Germany.
[Ti] Título:Downregulation of monocytic differentiation via modulation of CD147 by 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors.
[So] Source:PLoS One;12(12):e0189701, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CD147 is an activation induced glycoprotein that promotes the secretion and activation of matrix metalloproteinases (MMPs) and is upregulated during the differentiation of macrophages. Interestingly, some of the molecular functions of CD147 rely on its glycosylation status: the highly glycosylated forms of CD147 induce MMPs whereas the lowly glycosylated forms inhibit MMP activation. Statins are hydroxy-methylglutaryl coenzyme A reductase inhibitors that block the synthesis of mevalonate, thereby inhibiting all mevalonate-dependent pathways, including isoprenylation, N-glycosylation and cholesterol synthesis. In this study, we investigated the role of statins in the inhibition of macrophage differentiation and the associated process of MMP secretion through modulation of CD147. We observed that differentiation of the human monocytic cell line THP-1 to a macrophage phenotype led to upregulation of CD147 and CD14 and that this effect was inhibited by statins. At the molecular level, statins altered CD147 expression, structure and function by inhibiting isoprenylation and N-glycosylation. In addition, statins induced a shift of CD147 from its highly glycosylated form to its lowly glycosylated form. This shift in N-glycosylation status was accompanied by a decrease in the production and functional activity of MMP-2 and MMP-9. In conclusion, these findings describe a novel molecular mechanism of immune regulation by statins, making them interesting candidates for autoimmune disease therapy.
[Mh] Termos MeSH primário: Basigina/metabolismo
Inibidores de Hidroximetilglutaril-CoA Redutases/química
Receptores de Lipopolissacarídeos/metabolismo
Monócitos/efeitos dos fármacos
[Mh] Termos MeSH secundário: Doenças Autoimunes
Biotinilação
Diferenciação Celular
Membrana Celular/metabolismo
Glicosilação
Seres Humanos
Sistema Imunitário
Macrófagos/citologia
Macrófagos/efeitos dos fármacos
Metaloproteinase 2 da Matriz/metabolismo
Metaloproteinase 9 da Matriz/metabolismo
Monócitos/citologia
Permeabilidade
Fenótipo
Prenilação
Células THP-1
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (BSG protein, human); 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors); 0 (Lipopolysaccharide Receptors); 136894-56-9 (Basigin); EC 3.4.24.24 (MMP2 protein, human); EC 3.4.24.24 (Matrix Metalloproteinase 2); EC 3.4.24.35 (MMP9 protein, human); EC 3.4.24.35 (Matrix Metalloproteinase 9)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189701



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