Base de dados : MEDLINE Pesquisa : A16.378 [Categoria DeCS] Referências encontradas : 67080 [refinar] Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 6708

ir para página

1 / 67080

MEDLINE

seleciona para imprimir Fotocópia Texto completo

[PMID]: 28457750 [Au] Autor: Li L; Dong J; Yan L; Yong J; Liu X; Hu Y; Fan X; Wu X; Guo H; Wang X; Zhu X; Li R; Yan J; Wei Y; Zhao Y; Wang W; Ren Y; Yuan P; Yan Z; Hu B; Guo F; Wen L; Tang F; Qiao J [Ad] Endereço: Beijing Advanced Innovation Center for Genomics (ICG), College of Life Sciences, Department of Obstetrics and Gynecology, Third Hospital, Peking University, Beijing 100871, China; Biomedical Institute for Pioneering Investigation via Convergence and Center for Reproductive Medicine, Ministry of Educ [Ti] Título: Single-Cell RNA-Seq Analysis Maps Development of Human Germline Cells and Gonadal Niche Interactions. [So] Source: Cell Stem Cell;20(6):858-873.e4, 2017 Jun 01. [Is] ISSN: 1875-9777 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Human fetal germ cells (FGCs) are precursors to sperm and eggs and are crucial for maintenance of the species. However, the developmental trajectories and heterogeneity of human FGCs remain largely unknown. Here we performed single-cell RNA-seq analysis of over 2,000 FGCs and their gonadal niche cells in female and male human embryos spanning several developmental stages. We found that female FGCs undergo four distinct sequential phases characterized by mitosis, retinoic acid signaling, meiotic prophase, and oogenesis. Male FGCs develop through stages of migration, mitosis, and cell-cycle arrest. Individual embryos of both sexes simultaneously contain several subpopulations, highlighting the asynchronous and heterogeneous nature of FGC development. Moreover, we observed reciprocal signaling interactions between FGCs and their gonadal niche cells, including activation of the bone morphogenic protein (BMP) and Notch signaling pathways. Our work provides key insights into the crucial features of human FGCs during their highly ordered mitotic, meiotic, and gametogenetic processes in vivo. [Mh] Termos MeSH primário: Divisão Celular/fisiologia Células Germinativas Embrionárias/metabolismo Feto/metabolismo Gônadas/enzimologia Transdução de Sinais/fisiologia Nicho de Células-Tronco/fisiologia [Mh] Termos MeSH secundário: Proteínas Morfogenéticas Ósseas/metabolismo Células Germinativas Embrionárias/citologia Feminino Feto/citologia Gônadas/citologia Sequenciamento de Nucleotídeos em Larga Escala Seres Humanos Masculino Receptores Notch/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Bone Morphogenetic Proteins); 0 (Receptors, Notch) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170502 [St] Status: MEDLINE

2 / 67080

MEDLINE

seleciona para imprimir Fotocópia Texto completo

[PMID]: 29325266 [Au] Autor: Hu MN; Zhang Y; Zhao W [Ad] Endereço: Department of Health Care, Haidian Maternal and Child Health Hospital, Beijing 100080, China. [Ti] Título: [Analysis of 649 cases of stillbirth in third trimester]. [So] Source: Zhonghua Fu Chan Ke Za Zhi;52(12):822-827, 2017 Dec 25. [Is] ISSN: 0529-567X [Cp] País de publicação: China [La] Idioma: chi [Ab] Resumo: To analyze the risk factors of stillbirth in third trimester. Clinical data of 649 cases of stillbirth in third trimester were analyzed retrospectively in 22 hospitals of Haidian district from October 2011 to September 2016, including the incidence, the maternal profile, the perinatal care during pregnancy and the causes of stillbirth. (1) The incidence of stillbirth in third trimester in Haidian district from October 2011 to September 2016 was 0.293%(649/221 845). While the incidence in floating pregnant women (0.349%, 342/97 939) was higher than that in the residence (0.248%, 307/123 906), with statistically significant difference (χ(2)=19.178, <0.01). The incidence of stillbirth in multiple pregnancy(0.201%, 89/4 264) was higher than that in singleton pregnancy (0.257%, 560/217 581), with statistically significant difference(χ(2)=4.690, <0.01). There was no statistically significant difference in the incidence of stillbirth between male (0.300%, 347/115 632) and female fetuses (0.284%, 302/106 205; χ(2)=0.467, >0.05).(2)Among the 649 cases, the floating population accounted for the majority of those who never had prenatal visit (84.0%, 21/25), or less than 5 visits (80.7%, 125/155), or the first visit was beyond 13 gestational weeks(66.0%, 165/649). The causes of stillbirth in order were fetal factors (30.7%, 199/649), maternal factors(28.0%, 182/649), umbilical cord factors (20.0%, 130/649), unexplained factors (17.6%, 114/649) and placental factors (3.7%, 24/649). Birth defects, pregnancy hypertensive disorders, umbilical cord entanglement or torsion were the most important factors, accounting for 22.8%(148/649), 17.4%(113/649), 17.3%(112/649), respectively. The floating pregnant women are key population of stillbirth in third trimester. Maternal care and education should be strengthened in this population. The prevention of birth defect, better prenatal care in women with complications, and close monitor during labor are the key measures to reduce the incidence of stillbirth in third trimester. [Mh] Termos MeSH primário: Complicações na Gravidez/epidemiologia Terceiro Trimestre da Gravidez Natimorto/epidemiologia [Mh] Termos MeSH secundário: Adulto China/epidemiologia Feminino Feto Seres Humanos Placenta Gravidez Cuidado Pré-Natal Estudos Retrospectivos [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180306 [Lr] Data última revisão: 180306 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180112 [St] Status: MEDLINE [do] DOI: 10.3760/cma.j.issn.0529-567x.2017.12.006

3 / 67080

MEDLINE

seleciona para imprimir Fotocópia Texto completo

[PMID]: 29419378 [Au] Autor: Chappell LC; Chambers J; Thornton JG; Williamson C [Ad] Endereço: Women's Health Academic Centre, King's College London, London, UK lucy.chappell@kcl.ac.uk. [Ti] Título: Does ursodeoxycholic acid improve perinatal outcomes in women with intrahepatic cholestasis of pregnancy? [So] Source: BMJ;360:k104, 2018 02 01. [Is] ISSN: 1756-1833 [Cp] País de publicação: England [La] Idioma: eng [Mh] Termos MeSH primário: Colagogos e Coleréticos/efeitos adversos Colestase Intra-Hepática/tratamento farmacológico Feto/efeitos dos fármacos Complicações na Gravidez/tratamento farmacológico Ácido Ursodesoxicólico/efeitos adversos [Mh] Termos MeSH secundário: Colagogos e Coleréticos/administração & dosagem Colagogos e Coleréticos/uso terapêutico Colestase Intra-Hepática/epidemiologia Feminino Seres Humanos Gravidez Complicações na Gravidez/epidemiologia Resultado da Gravidez/epidemiologia Ácido Ursodesoxicólico/administração & dosagem Ácido Ursodesoxicólico/uso terapêutico [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Cholagogues and Choleretics); 724L30Y2QR (Ursodeoxycholic Acid) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180305 [Lr] Data última revisão: 180305 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180209 [St] Status: MEDLINE [do] DOI: 10.1136/bmj.k104

4 / 67080

MEDLINE

seleciona para imprimir Fotocópia

[PMID]: 29384346 [Au] Autor: Brione R [Ti] Título: To What Extent Does or Should a Woman's Autonomy Overrule the Interests of Her Baby? A Study of Autonomy-related Issues in the Context of Caesarean Section. [So] Source: New Bioeth;21(1):71-86, 2015. [Is] ISSN: 2050-2885 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Approaches to supporting autonomy in medicine need to be able to support complex and sensitive decision-making, incorporating reflection on the patient's values and goals. This should involve deliberation in partnership between physician and patient, allowing the patient to take responsibility for her decision. Nowhere is this truer than in decisions around pregnancy and Caesarean section where maternal autonomy can seem to directly conflict with foetal interests. Medical and societal expectations and norms such as the expectations of a 'mother', constraints of making decisions in an emergency, and the role of technology in viewing the foetus as a separate patient and surgery as a guarantor of results can all act to limit a woman's autonomy. In considering decisions about Caesarean section, maternal interests in bodily integrity can be dismissed as being less important than the foetus's own interests and the mother's duties to it, despite the inherent risks and impacts of such a major surgical procedure. Maternal autonomy must be respected through support for informed deliberation, incorporating patients' own values and risk tolerance, with the aim of minimizing the effect of those factors that would tend to limit autonomy. [Mh] Termos MeSH primário: Cesárea Tomada de Decisões Feto Autonomia Pessoal [Mh] Termos MeSH secundário: Feminino Seres Humanos Gravidez Risco [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180226 [Lr] Data última revisão: 180226 [Sb] Subgrupo de revista: E; IM [Da] Data de entrada para processamento: 180201 [St] Status: MEDLINE

5 / 67080

MEDLINE

seleciona para imprimir Fotocópia Texto completo

[PMID]: 28456747 [Au] Autor: He Q; Gao S; Lv J; Li W; Liu F [Ad] Endereço: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China. [Ti] Título: BLOS2 maintains hematopoietic stem cells in the fetal liver via repressing Notch signaling. [So] Source: Exp Hematol;51:1-6.e2, 2017 07. [Is] ISSN: 1873-2399 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: During development, hematopoietic stem cells (HSCs) undergo a rapid expansion in the fetal liver (FL) after their emergence in the aorta-gonad-mesonephros (AGM) region. We recently reported that the endolysosomal trafficking factor BLOS2, encoded by the Bloc1s2 gene, regulates HSC/hematopoietic progenitor cell emergence in the AGM region; however, whether it plays a role in the FL remains unknown. Here, we show that BLOS2 plays an essential role in the regulation of HSC proliferation and differentiation in the FL. Bloc1s2 depletion leads to elevated Notch signaling, with an increased frequency but weakened self-renewal ability of FL HSCs. Functional assays show that Bloc1s2 FL HSCs harbor impaired lymphoid and myeloid differentiation abilities. These findings reveal that balanced control of Notch signaling by BLOS2 is required for HSC homeostasis during FL hematopoiesis. [Mh] Termos MeSH primário: Diferenciação Celular/fisiologia Proliferação Celular/fisiologia Feto/embriologia Células-Tronco Hematopoéticas/metabolismo Fígado/embriologia Proteínas/metabolismo Receptores Notch/metabolismo [Mh] Termos MeSH secundário: Animais Feto/citologia Hematopoese Extramedular/fisiologia Células-Tronco Hematopoéticas/citologia Seres Humanos Fígado/citologia Camundongos Camundongos Knockout Proteínas/genética Receptores Notch/genética [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (BLOS2 protein, mouse); 0 (Proteins); 0 (Receptors, Notch) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 180224 [Lr] Data última revisão: 180224 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170501 [St] Status: MEDLINE

6 / 67080

MEDLINE

seleciona para imprimir Fotocópia Texto completo

[PMID]: 28453379 [Au] Autor: Han M; Afshar Y; Chon AH; Scibetta E; Rao R; Chmait RH [Ad] Endereço: a Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology , University of California , Los Angeles, Los Angeles , California , USA. [Ti] Título: Pseudoamniotic Band Syndrome Post Fetal Thoracoamniotic Shunting for Bilateral Hydrothorax. [So] Source: Fetal Pediatr Pathol;36(4):311-318, 2017 Aug. [Is] ISSN: 1551-3823 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: INTRODUCTION: Pseudoamniotic band syndrome (PABS) occurs iatrogenically after fetal surgery or amniocentesis due to chorioamniotic membrane separation. Separation of the amnion from the chorion can expand to form fibrous amniotic bands that can envelope fetal limbs or the umbilical cord, with consequences ranging from limb constriction to fetal demise. CASE REPORT: We report a case of bilateral fetal pleural effusions at 27 weeks' gestation treated by bilateral thoracoamniotic shunts. Following shunt placement, the hydrothorax resolved. However, chorioamniotic membrane separation developed resulting in PABS with subsequent umbilical cord strangulation and fetal demise at 32 weeks' gestation. CONCLUSION: PABS has been previously described in the literature following various fetal interventions. This is the first reported case of pseudoamniotic band syndrome after placement of fetal thoracoamniotic shunts. A high index of suspicion is required to diagnose PABS via postoperative ultrasound. Post intervention chorioamniotic membrane separation warrants close surveillance for sonographic evidence of PABS. [Mh] Termos MeSH primário: Síndrome de Bandas Amnióticas/etiologia Quilotórax/congênito Terapias Fetais/efeitos adversos Hidropisia Fetal/cirurgia [Mh] Termos MeSH secundário: Quilotórax/cirurgia Feminino Morte Fetal Feto Seres Humanos Derrame Pleural/cirurgia Gravidez [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180222 [Lr] Data última revisão: 180222 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170429 [St] Status: MEDLINE [do] DOI: 10.1080/15513815.2017.1313915

7 / 67080

MEDLINE

seleciona para imprimir Fotocópia Texto completo

[PMID]: 29329878 [Au] Autor: Chen Z; Zhao Z; Li Y; Zhang X; Li B; Chen L; Wang H [Ad] Endereço: Department of Pharmacology, Basic Medical School of Wuhan University, No.185 Donghu Road, Wuhan, Hubei Province, 430071, China. [Ti] Título: Course-, dose-, and stage-dependent toxic effects of prenatal dexamethasone exposure on fetal articular cartilage development. [So] Source: Toxicol Lett;286:1-9, 2018 Apr. [Is] ISSN: 1879-3169 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: Dexamethasone, a synthetic long-acting glucocorticoid, is routinely used for treating mothers at risk for preterm delivery. However, intrauterine overexposure to glucocorticoids induces low birth weight and cartilage dysplasia in offspring. Also, the "critical window" and safe dose of this treatment are largely unknown. This study investigated the course-, dose-, and stage-dependent toxic effects and the possible mechanisms of prenatal dexamethasone exposure (PDE) on fetal development and articular cartilage development. Pregnant mice (C57BL/6) received subcutaneous injection of dexamethasone (0.8 mg/kg d) once on gestational day (GD) 15 or once a day from GD 15 to 17, or received various doses of dexamethasone (0, 0.2, 0.8, and 1.2 mg/kg d) on GD 15-17, or received dexamethasone (0.8 mg/kg d) at early stage (GD 12-14) or late stage of pregnancy (GD 15-17). Offspring's knee joints were harvested at birth for morphological analyses and detection of gene expression. Repeated PDE significantly suppressed fetal and articular cartilage development, which were characterized by decreased body weight and body length, coarse articular cartilage surfaces, and reduced gene and protein expression of Col2a1 and aggrecan. For those newborns treated with repeated PDE at different doses, the toxic effects on fetal and articular cartilage development were observed at doses of 0.8 and 1.2 mg/kg d, whereas no obvious toxic effects were observed at the dose of 0.2 mg/kg d. Moreover, PDE at 0.8 mg/kg d during the early embryonic stage induced stronger toxic effects on fetal and articular cartilage development, compared with PDE during the late embryonic stage. Detection of gene expression showed that the TGFß signaling pathway in the articular cartilage was down-regulated after PDE. Taken together, PDE induces fetal developmental toxicity and articular cartilage developmental toxicity in a course-, dose-, and stage-dependent manner. [Mh] Termos MeSH primário: Cartilagem Articular/efeitos dos fármacos Condrogênese/efeitos dos fármacos Dexametasona/toxicidade Feto/efeitos dos fármacos Glucocorticoides/toxicidade [Mh] Termos MeSH secundário: Agrecanas/genética Agrecanas/metabolismo Animais Cartilagem Articular/embriologia Cartilagem Articular/metabolismo Colágeno Tipo II/genética Colágeno Tipo II/metabolismo Dexametasona/administração & dosagem Relação Dose-Resposta a Droga Feminino Feto/metabolismo Feto/patologia Regulação da Expressão Gênica no Desenvolvimento/efeitos dos fármacos Idade Gestacional Glucocorticoides/administração & dosagem Exposição Materna Camundongos Endogâmicos C57BL Gravidez Medição de Risco Transdução de Sinais/efeitos dos fármacos Fator de Crescimento Transformador beta/genética Fator de Crescimento Transformador beta/metabolismo [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Aggrecans); 0 (Col2a1 protein, mouse); 0 (Collagen Type II); 0 (Glucocorticoids); 0 (Transforming Growth Factor beta); 7S5I7G3JQL (Dexamethasone) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180220 [Lr] Data última revisão: 180220 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180114 [St] Status: MEDLINE

8 / 67080

MEDLINE

seleciona para imprimir Fotocópia Texto completo

[PMID]: 29343712 [Au] Autor: Hirsch AJ; Roberts VHJ; Grigsby PL; Haese N; Schabel MC; Wang X; Lo JO; Liu Z; Kroenke CD; Smith JL; Kelleher M; Broeckel R; Kreklywich CN; Parkins CJ; Denton M; Smith P; DeFilippis V; Messer W; Nelson JA; Hennebold JD; Grafe M; Colgin L; Lewis A; Ducore R; Swanson T; Legasse AW; Axthelm MK; MacAllister R; Moses AV; Morgan TK; Frias AE; Streblow DN [Ad] Endereço: The Vaccine & Gene Institute, Oregon Health and Science University (OHSU), 505 NW 185th Ave, Beaverton, 97006, USA. hirschal@ohsu.edu. [Ti] Título: Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology. [So] Source: Nat Commun;9(1):263, 2018 01 17. [Is] ISSN: 2041-1723 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Zika virus (ZIKV) infection during pregnancy leads to an increased risk of fetal growth restriction and fetal central nervous system malformations, which are outcomes broadly referred to as the Congenital Zika Syndrome (CZS). Here we infect pregnant rhesus macaques and investigate the impact of persistent ZIKV infection on uteroplacental pathology, blood flow, and fetal growth and development. Despite seemingly normal fetal growth and persistent fetal-placenta-maternal infection, advanced non-invasive in vivo imaging studies reveal dramatic effects on placental oxygen reserve accompanied by significantly decreased oxygen permeability of the placental villi. The observation of abnormal oxygen transport within the placenta appears to be a consequence of uterine vasculitis and placental villous damage in ZIKV cases. In addition, we demonstrate a robust maternal-placental-fetal inflammatory response following ZIKV infection. This animal model reveals a potential relationship between ZIKV infection and uteroplacental pathology that appears to affect oxygen delivery to the fetus during development. [Mh] Termos MeSH primário: Placenta/metabolismo Circulação Placentária Complicações Infecciosas na Gravidez/imunologia Infecção pelo Zika virus/imunologia [Mh] Termos MeSH secundário: Imunidade Adaptativa Animais Encéfalo/embriologia Encéfalo/patologia Citocinas/sangue Modelos Animais de Doenças Feminino Desenvolvimento Fetal Feto/patologia Imunidade Inata Macaca mulatta Imagem por Ressonância Magnética Oxigênio/metabolismo Permeabilidade Placenta/imunologia Placenta/patologia Placenta/virologia Gravidez Complicações Infecciosas na Gravidez/metabolismo Complicações Infecciosas na Gravidez/patologia Complicações Infecciosas na Gravidez/fisiopatologia Carga Viral Infecção pelo Zika virus/metabolismo Infecção pelo Zika virus/patologia Infecção pelo Zika virus/fisiopatologia [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Cytokines); S88TT14065 (Oxygen) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180215 [Lr] Data última revisão: 180215 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180119 [St] Status: MEDLINE [do] DOI: 10.1038/s41467-017-02499-9

9 / 67080

MEDLINE

seleciona para imprimir Fotocópia Texto completo

[PMID]: 28456990 [Au] Autor: Verma J; Bijarnia-Mahay S; Verma IC [Ad] Endereço: Institute of Medical Genetics and Genomics, Sir Ganga Ram Hospital, New Delhi, India. [Ti] Título: Prenatal Diagnosis of Lysosomal Storage Disorders Using Chorionic Villi. [So] Source: Methods Mol Biol;1594:265-291, 2017. [Is] ISSN: 1940-6029 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Prenatal enzymatic diagnosis for an array of lysosomal storage disorders (LSDs) can be performed accurately, provided that a confirmed diagnosis by biochemical/molecular study in the index case is available and a strict defined protocol, specific to each individual disorder is followed. The present chapter describes the protocols for reliable and accurate prenatal enzymatic diagnoses by fluorometric and spectrophotometric methods of lysosomal storage disorders: Gaucher, Fabry, Pompe, Niemann Pick A/B, Tay Sach, Sandhoff, GM1, Mucoplysaccharidoses, Wolman, Krabbe, Metachromatic leukodystrophy, and Batten diseases using uncultured chorionic villi samples. The biological reference intervals for enzyme levels in normal and affected fetuses are given for interpretation of prenatal results. It is imperative to establish normal reference interval in each laboratory to take into account the local environment, technical variations, and different ethnicities. Besides, enzyme activity in the fetus should be represented as percentage of the mean activity of enzyme of normal fetuses. The pitfalls and challenges in prenatal diagnosis as well as technical problems in performing enzyme assays are also discussed to help the reader in standardization and performing the assays for correct diagnosis. [Mh] Termos MeSH primário: Vilosidades Coriônicas/enzimologia Vilosidades Coriônicas/metabolismo Doenças por Armazenamento dos Lisossomos/diagnóstico Doenças por Armazenamento dos Lisossomos/enzimologia Diagnóstico Pré-Natal/métodos [Mh] Termos MeSH secundário: Feminino Feto/enzimologia Feto/metabolismo Seres Humanos Gravidez [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180212 [Lr] Data última revisão: 180212 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170501 [St] Status: MEDLINE [do] DOI: 10.1007/978-1-4939-6934-0_18

10 / 67080

MEDLINE

seleciona para imprimir Fotocópia

[PMID]: 29323840 [Au] Autor: Galegov GA [Ti] Título: Phosphazide (nikavir) is a highly effective drug for the treatment of HIV/AIDS infection. [So] Source: Vopr Virusol;62(1):5-11, 2017. [Is] ISSN: 0507-4088 [Cp] País de publicação: Russia (Federation) [La] Idioma: eng [Ab] Resumo: Federation Convincing evidence for high therapeutic activity and tolerability of Phosphazide in the treatment of HIV/AIDS-infection is given. Phosphazide is currently used in various regimens of highly active antiretroviral therapy, as well as in the HIV therapy in patients with simultaneously acquired chronic hepatitis C or tuberculosis. Therapeutic possibilities of Phosphazide were clearly manifested in the prevention of HIV transmission from mother to child. There is every reason to use Phosphazide in first-line antiretroviral therapy. [Mh] Termos MeSH primário: Fármacos Anti-HIV/uso terapêutico Infecções por HIV/tratamento farmacológico HIV/efeitos dos fármacos Transmissão Vertical de Doença Infecciosa/prevenção & controle Organofosfonatos/uso terapêutico Complicações Infecciosas na Gravidez/tratamento farmacológico Zidovudina/análogos & derivados [Mh] Termos MeSH secundário: Fármacos Anti-HIV/farmacocinética Terapia Antirretroviral de Alta Atividade/métodos Feminino Feto HIV/genética HIV/metabolismo Infecções por HIV/transmissão Infecções por HIV/virologia Seres Humanos Organofosfonatos/farmacocinética Gravidez Complicações Infecciosas na Gravidez/virologia Resultado do Tratamento Zidovudina/farmacocinética Zidovudina/uso terapêutico [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (3'-azido-2',3'-dideoxythymidine 5'-H-phoshonate); 0 (Anti-HIV Agents); 0 (Organophosphonates); 4B9XT59T7S (Zidovudine) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180208 [Lr] Data última revisão: 180208 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180112 [St] Status: MEDLINE

---

página 1 de 6708

ir para página

Refinar a pesquisa

Base de dados : MEDLINE

Formulário avançado

		Pesquisar	no campo
1			PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
2	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
3	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2

Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde