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[PMID]:28457750
[Au] Autor:Li L; Dong J; Yan L; Yong J; Liu X; Hu Y; Fan X; Wu X; Guo H; Wang X; Zhu X; Li R; Yan J; Wei Y; Zhao Y; Wang W; Ren Y; Yuan P; Yan Z; Hu B; Guo F; Wen L; Tang F; Qiao J
[Ad] Endereço:Beijing Advanced Innovation Center for Genomics (ICG), College of Life Sciences, Department of Obstetrics and Gynecology, Third Hospital, Peking University, Beijing 100871, China; Biomedical Institute for Pioneering Investigation via Convergence and Center for Reproductive Medicine, Ministry of Educ
[Ti] Título:Single-Cell RNA-Seq Analysis Maps Development of Human Germline Cells and Gonadal Niche Interactions.
[So] Source:Cell Stem Cell;20(6):858-873.e4, 2017 Jun 01.
[Is] ISSN:1875-9777
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Human fetal germ cells (FGCs) are precursors to sperm and eggs and are crucial for maintenance of the species. However, the developmental trajectories and heterogeneity of human FGCs remain largely unknown. Here we performed single-cell RNA-seq analysis of over 2,000 FGCs and their gonadal niche cells in female and male human embryos spanning several developmental stages. We found that female FGCs undergo four distinct sequential phases characterized by mitosis, retinoic acid signaling, meiotic prophase, and oogenesis. Male FGCs develop through stages of migration, mitosis, and cell-cycle arrest. Individual embryos of both sexes simultaneously contain several subpopulations, highlighting the asynchronous and heterogeneous nature of FGC development. Moreover, we observed reciprocal signaling interactions between FGCs and their gonadal niche cells, including activation of the bone morphogenic protein (BMP) and Notch signaling pathways. Our work provides key insights into the crucial features of human FGCs during their highly ordered mitotic, meiotic, and gametogenetic processes in vivo.
[Mh] Termos MeSH primário: Divisão Celular/fisiologia
Células Germinativas Embrionárias/metabolismo
Feto/metabolismo
Gônadas/enzimologia
Transdução de Sinais/fisiologia
Nicho de Células-Tronco/fisiologia
[Mh] Termos MeSH secundário: Proteínas Morfogenéticas Ósseas/metabolismo
Células Germinativas Embrionárias/citologia
Feminino
Feto/citologia
Gônadas/citologia
Sequenciamento de Nucleotídeos em Larga Escala
Seres Humanos
Masculino
Receptores Notch/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bone Morphogenetic Proteins); 0 (Receptors, Notch)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


  2 / 67080 MEDLINE  
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[PMID]:29325266
[Au] Autor:Hu MN; Zhang Y; Zhao W
[Ad] Endereço:Department of Health Care, Haidian Maternal and Child Health Hospital, Beijing 100080, China.
[Ti] Título:[Analysis of 649 cases of stillbirth in third trimester].
[So] Source:Zhonghua Fu Chan Ke Za Zhi;52(12):822-827, 2017 Dec 25.
[Is] ISSN:0529-567X
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To analyze the risk factors of stillbirth in third trimester. Clinical data of 649 cases of stillbirth in third trimester were analyzed retrospectively in 22 hospitals of Haidian district from October 2011 to September 2016, including the incidence, the maternal profile, the perinatal care during pregnancy and the causes of stillbirth. (1) The incidence of stillbirth in third trimester in Haidian district from October 2011 to September 2016 was 0.293%(649/221 845). While the incidence in floating pregnant women (0.349%, 342/97 939) was higher than that in the residence (0.248%, 307/123 906), with statistically significant difference (χ(2)=19.178, <0.01). The incidence of stillbirth in multiple pregnancy(0.201%, 89/4 264) was higher than that in singleton pregnancy (0.257%, 560/217 581), with statistically significant difference(χ(2)=4.690, <0.01). There was no statistically significant difference in the incidence of stillbirth between male (0.300%, 347/115 632) and female fetuses (0.284%, 302/106 205; χ(2)=0.467, >0.05).(2)Among the 649 cases, the floating population accounted for the majority of those who never had prenatal visit (84.0%, 21/25), or less than 5 visits (80.7%, 125/155), or the first visit was beyond 13 gestational weeks(66.0%, 165/649). The causes of stillbirth in order were fetal factors (30.7%, 199/649), maternal factors(28.0%, 182/649), umbilical cord factors (20.0%, 130/649), unexplained factors (17.6%, 114/649) and placental factors (3.7%, 24/649). Birth defects, pregnancy hypertensive disorders, umbilical cord entanglement or torsion were the most important factors, accounting for 22.8%(148/649), 17.4%(113/649), 17.3%(112/649), respectively. The floating pregnant women are key population of stillbirth in third trimester. Maternal care and education should be strengthened in this population. The prevention of birth defect, better prenatal care in women with complications, and close monitor during labor are the key measures to reduce the incidence of stillbirth in third trimester.
[Mh] Termos MeSH primário: Complicações na Gravidez/epidemiologia
Terceiro Trimestre da Gravidez
Natimorto/epidemiologia
[Mh] Termos MeSH secundário: Adulto
China/epidemiologia
Feminino
Feto
Seres Humanos
Placenta
Gravidez
Cuidado Pré-Natal
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0529-567x.2017.12.006


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[PMID]:29419378
[Au] Autor:Chappell LC; Chambers J; Thornton JG; Williamson C
[Ad] Endereço:Women's Health Academic Centre, King's College London, London, UK lucy.chappell@kcl.ac.uk.
[Ti] Título:Does ursodeoxycholic acid improve perinatal outcomes in women with intrahepatic cholestasis of pregnancy?
[So] Source:BMJ;360:k104, 2018 02 01.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Colagogos e Coleréticos/efeitos adversos
Colestase Intra-Hepática/tratamento farmacológico
Feto/efeitos dos fármacos
Complicações na Gravidez/tratamento farmacológico
Ácido Ursodesoxicólico/efeitos adversos
[Mh] Termos MeSH secundário: Colagogos e Coleréticos/administração & dosagem
Colagogos e Coleréticos/uso terapêutico
Colestase Intra-Hepática/epidemiologia
Feminino
Seres Humanos
Gravidez
Complicações na Gravidez/epidemiologia
Resultado da Gravidez/epidemiologia
Ácido Ursodesoxicólico/administração & dosagem
Ácido Ursodesoxicólico/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cholagogues and Choleretics); 724L30Y2QR (Ursodeoxycholic Acid)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180209
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.k104


  4 / 67080 MEDLINE  
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[PMID]:29384346
[Au] Autor:Brione R
[Ti] Título:To What Extent Does or Should a Woman's Autonomy Overrule the Interests of Her Baby? A Study of Autonomy-related Issues in the Context of Caesarean Section.
[So] Source:New Bioeth;21(1):71-86, 2015.
[Is] ISSN:2050-2885
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Approaches to supporting autonomy in medicine need to be able to support complex and sensitive decision-making, incorporating reflection on the patient's values and goals. This should involve deliberation in partnership between physician and patient, allowing the patient to take responsibility for her decision. Nowhere is this truer than in decisions around pregnancy and Caesarean section where maternal autonomy can seem to directly conflict with foetal interests. Medical and societal expectations and norms such as the expectations of a 'mother', constraints of making decisions in an emergency, and the role of technology in viewing the foetus as a separate patient and surgery as a guarantor of results can all act to limit a woman's autonomy. In considering decisions about Caesarean section, maternal interests in bodily integrity can be dismissed as being less important than the foetus's own interests and the mother's duties to it, despite the inherent risks and impacts of such a major surgical procedure. Maternal autonomy must be respected through support for informed deliberation, incorporating patients' own values and risk tolerance, with the aim of minimizing the effect of those factors that would tend to limit autonomy.
[Mh] Termos MeSH primário: Cesárea
Tomada de Decisões
Feto
Autonomia Pessoal
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Gravidez
Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:E; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE


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[PMID]:28456747
[Au] Autor:He Q; Gao S; Lv J; Li W; Liu F
[Ad] Endereço:State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China.
[Ti] Título:BLOS2 maintains hematopoietic stem cells in the fetal liver via repressing Notch signaling.
[So] Source:Exp Hematol;51:1-6.e2, 2017 07.
[Is] ISSN:1873-2399
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:During development, hematopoietic stem cells (HSCs) undergo a rapid expansion in the fetal liver (FL) after their emergence in the aorta-gonad-mesonephros (AGM) region. We recently reported that the endolysosomal trafficking factor BLOS2, encoded by the Bloc1s2 gene, regulates HSC/hematopoietic progenitor cell emergence in the AGM region; however, whether it plays a role in the FL remains unknown. Here, we show that BLOS2 plays an essential role in the regulation of HSC proliferation and differentiation in the FL. Bloc1s2 depletion leads to elevated Notch signaling, with an increased frequency but weakened self-renewal ability of FL HSCs. Functional assays show that Bloc1s2 FL HSCs harbor impaired lymphoid and myeloid differentiation abilities. These findings reveal that balanced control of Notch signaling by BLOS2 is required for HSC homeostasis during FL hematopoiesis.
[Mh] Termos MeSH primário: Diferenciação Celular/fisiologia
Proliferação Celular/fisiologia
Feto/embriologia
Células-Tronco Hematopoéticas/metabolismo
Fígado/embriologia
Proteínas/metabolismo
Receptores Notch/metabolismo
[Mh] Termos MeSH secundário: Animais
Feto/citologia
Hematopoese Extramedular/fisiologia
Células-Tronco Hematopoéticas/citologia
Seres Humanos
Fígado/citologia
Camundongos
Camundongos Knockout
Proteínas/genética
Receptores Notch/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (BLOS2 protein, mouse); 0 (Proteins); 0 (Receptors, Notch)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180224
[Lr] Data última revisão:
180224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE


  6 / 67080 MEDLINE  
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[PMID]:28453379
[Au] Autor:Han M; Afshar Y; Chon AH; Scibetta E; Rao R; Chmait RH
[Ad] Endereço:a Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology , University of California , Los Angeles, Los Angeles , California , USA.
[Ti] Título:Pseudoamniotic Band Syndrome Post Fetal Thoracoamniotic Shunting for Bilateral Hydrothorax.
[So] Source:Fetal Pediatr Pathol;36(4):311-318, 2017 Aug.
[Is] ISSN:1551-3823
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Pseudoamniotic band syndrome (PABS) occurs iatrogenically after fetal surgery or amniocentesis due to chorioamniotic membrane separation. Separation of the amnion from the chorion can expand to form fibrous amniotic bands that can envelope fetal limbs or the umbilical cord, with consequences ranging from limb constriction to fetal demise. CASE REPORT: We report a case of bilateral fetal pleural effusions at 27 weeks' gestation treated by bilateral thoracoamniotic shunts. Following shunt placement, the hydrothorax resolved. However, chorioamniotic membrane separation developed resulting in PABS with subsequent umbilical cord strangulation and fetal demise at 32 weeks' gestation. CONCLUSION: PABS has been previously described in the literature following various fetal interventions. This is the first reported case of pseudoamniotic band syndrome after placement of fetal thoracoamniotic shunts. A high index of suspicion is required to diagnose PABS via postoperative ultrasound. Post intervention chorioamniotic membrane separation warrants close surveillance for sonographic evidence of PABS.
[Mh] Termos MeSH primário: Síndrome de Bandas Amnióticas/etiologia
Quilotórax/congênito
Terapias Fetais/efeitos adversos
Hidropisia Fetal/cirurgia
[Mh] Termos MeSH secundário: Quilotórax/cirurgia
Feminino
Morte Fetal
Feto
Seres Humanos
Derrame Pleural/cirurgia
Gravidez
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1080/15513815.2017.1313915


  7 / 67080 MEDLINE  
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[PMID]:29329878
[Au] Autor:Chen Z; Zhao Z; Li Y; Zhang X; Li B; Chen L; Wang H
[Ad] Endereço:Department of Pharmacology, Basic Medical School of Wuhan University, No.185 Donghu Road, Wuhan, Hubei Province, 430071, China.
[Ti] Título:Course-, dose-, and stage-dependent toxic effects of prenatal dexamethasone exposure on fetal articular cartilage development.
[So] Source:Toxicol Lett;286:1-9, 2018 Apr.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Dexamethasone, a synthetic long-acting glucocorticoid, is routinely used for treating mothers at risk for preterm delivery. However, intrauterine overexposure to glucocorticoids induces low birth weight and cartilage dysplasia in offspring. Also, the "critical window" and safe dose of this treatment are largely unknown. This study investigated the course-, dose-, and stage-dependent toxic effects and the possible mechanisms of prenatal dexamethasone exposure (PDE) on fetal development and articular cartilage development. Pregnant mice (C57BL/6) received subcutaneous injection of dexamethasone (0.8 mg/kg d) once on gestational day (GD) 15 or once a day from GD 15 to 17, or received various doses of dexamethasone (0, 0.2, 0.8, and 1.2 mg/kg d) on GD 15-17, or received dexamethasone (0.8 mg/kg d) at early stage (GD 12-14) or late stage of pregnancy (GD 15-17). Offspring's knee joints were harvested at birth for morphological analyses and detection of gene expression. Repeated PDE significantly suppressed fetal and articular cartilage development, which were characterized by decreased body weight and body length, coarse articular cartilage surfaces, and reduced gene and protein expression of Col2a1 and aggrecan. For those newborns treated with repeated PDE at different doses, the toxic effects on fetal and articular cartilage development were observed at doses of 0.8 and 1.2 mg/kg d, whereas no obvious toxic effects were observed at the dose of 0.2 mg/kg d. Moreover, PDE at 0.8 mg/kg d during the early embryonic stage induced stronger toxic effects on fetal and articular cartilage development, compared with PDE during the late embryonic stage. Detection of gene expression showed that the TGFß signaling pathway in the articular cartilage was down-regulated after PDE. Taken together, PDE induces fetal developmental toxicity and articular cartilage developmental toxicity in a course-, dose-, and stage-dependent manner.
[Mh] Termos MeSH primário: Cartilagem Articular/efeitos dos fármacos
Condrogênese/efeitos dos fármacos
Dexametasona/toxicidade
Feto/efeitos dos fármacos
Glucocorticoides/toxicidade
[Mh] Termos MeSH secundário: Agrecanas/genética
Agrecanas/metabolismo
Animais
Cartilagem Articular/embriologia
Cartilagem Articular/metabolismo
Colágeno Tipo II/genética
Colágeno Tipo II/metabolismo
Dexametasona/administração & dosagem
Relação Dose-Resposta a Droga
Feminino
Feto/metabolismo
Feto/patologia
Regulação da Expressão Gênica no Desenvolvimento/efeitos dos fármacos
Idade Gestacional
Glucocorticoides/administração & dosagem
Exposição Materna
Camundongos Endogâmicos C57BL
Gravidez
Medição de Risco
Transdução de Sinais/efeitos dos fármacos
Fator de Crescimento Transformador beta/genética
Fator de Crescimento Transformador beta/metabolismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aggrecans); 0 (Col2a1 protein, mouse); 0 (Collagen Type II); 0 (Glucocorticoids); 0 (Transforming Growth Factor beta); 7S5I7G3JQL (Dexamethasone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180114
[St] Status:MEDLINE


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[PMID]:29343712
[Au] Autor:Hirsch AJ; Roberts VHJ; Grigsby PL; Haese N; Schabel MC; Wang X; Lo JO; Liu Z; Kroenke CD; Smith JL; Kelleher M; Broeckel R; Kreklywich CN; Parkins CJ; Denton M; Smith P; DeFilippis V; Messer W; Nelson JA; Hennebold JD; Grafe M; Colgin L; Lewis A; Ducore R; Swanson T; Legasse AW; Axthelm MK; MacAllister R; Moses AV; Morgan TK; Frias AE; Streblow DN
[Ad] Endereço:The Vaccine & Gene Institute, Oregon Health and Science University (OHSU), 505 NW 185th Ave, Beaverton, 97006, USA. hirschal@ohsu.edu.
[Ti] Título:Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology.
[So] Source:Nat Commun;9(1):263, 2018 01 17.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Zika virus (ZIKV) infection during pregnancy leads to an increased risk of fetal growth restriction and fetal central nervous system malformations, which are outcomes broadly referred to as the Congenital Zika Syndrome (CZS). Here we infect pregnant rhesus macaques and investigate the impact of persistent ZIKV infection on uteroplacental pathology, blood flow, and fetal growth and development. Despite seemingly normal fetal growth and persistent fetal-placenta-maternal infection, advanced non-invasive in vivo imaging studies reveal dramatic effects on placental oxygen reserve accompanied by significantly decreased oxygen permeability of the placental villi. The observation of abnormal oxygen transport within the placenta appears to be a consequence of uterine vasculitis and placental villous damage in ZIKV cases. In addition, we demonstrate a robust maternal-placental-fetal inflammatory response following ZIKV infection. This animal model reveals a potential relationship between ZIKV infection and uteroplacental pathology that appears to affect oxygen delivery to the fetus during development.
[Mh] Termos MeSH primário: Placenta/metabolismo
Circulação Placentária
Complicações Infecciosas na Gravidez/imunologia
Infecção pelo Zika virus/imunologia
[Mh] Termos MeSH secundário: Imunidade Adaptativa
Animais
Encéfalo/embriologia
Encéfalo/patologia
Citocinas/sangue
Modelos Animais de Doenças
Feminino
Desenvolvimento Fetal
Feto/patologia
Imunidade Inata
Macaca mulatta
Imagem por Ressonância Magnética
Oxigênio/metabolismo
Permeabilidade
Placenta/imunologia
Placenta/patologia
Placenta/virologia
Gravidez
Complicações Infecciosas na Gravidez/metabolismo
Complicações Infecciosas na Gravidez/patologia
Complicações Infecciosas na Gravidez/fisiopatologia
Carga Viral
Infecção pelo Zika virus/metabolismo
Infecção pelo Zika virus/patologia
Infecção pelo Zika virus/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cytokines); S88TT14065 (Oxygen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180119
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02499-9


  9 / 67080 MEDLINE  
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[PMID]:28456990
[Au] Autor:Verma J; Bijarnia-Mahay S; Verma IC
[Ad] Endereço:Institute of Medical Genetics and Genomics, Sir Ganga Ram Hospital, New Delhi, India.
[Ti] Título:Prenatal Diagnosis of Lysosomal Storage Disorders Using Chorionic Villi.
[So] Source:Methods Mol Biol;1594:265-291, 2017.
[Is] ISSN:1940-6029
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Prenatal enzymatic diagnosis for an array of lysosomal storage disorders (LSDs) can be performed accurately, provided that a confirmed diagnosis by biochemical/molecular study in the index case is available and a strict defined protocol, specific to each individual disorder is followed. The present chapter describes the protocols for reliable and accurate prenatal enzymatic diagnoses by fluorometric and spectrophotometric methods of lysosomal storage disorders: Gaucher, Fabry, Pompe, Niemann Pick A/B, Tay Sach, Sandhoff, GM1, Mucoplysaccharidoses, Wolman, Krabbe, Metachromatic leukodystrophy, and Batten diseases using uncultured chorionic villi samples. The biological reference intervals for enzyme levels in normal and affected fetuses are given for interpretation of prenatal results. It is imperative to establish normal reference interval in each laboratory to take into account the local environment, technical variations, and different ethnicities. Besides, enzyme activity in the fetus should be represented as percentage of the mean activity of enzyme of normal fetuses. The pitfalls and challenges in prenatal diagnosis as well as technical problems in performing enzyme assays are also discussed to help the reader in standardization and performing the assays for correct diagnosis.
[Mh] Termos MeSH primário: Vilosidades Coriônicas/enzimologia
Vilosidades Coriônicas/metabolismo
Doenças por Armazenamento dos Lisossomos/diagnóstico
Doenças por Armazenamento dos Lisossomos/enzimologia
Diagnóstico Pré-Natal/métodos
[Mh] Termos MeSH secundário: Feminino
Feto/enzimologia
Feto/metabolismo
Seres Humanos
Gravidez
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE
[do] DOI:10.1007/978-1-4939-6934-0_18


  10 / 67080 MEDLINE  
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[PMID]:29323840
[Au] Autor:Galegov GA
[Ti] Título:Phosphazide (nikavir) is a highly effective drug for the treatment of HIV/AIDS infection.
[So] Source:Vopr Virusol;62(1):5-11, 2017.
[Is] ISSN:0507-4088
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:Federation Convincing evidence for high therapeutic activity and tolerability of Phosphazide in the treatment of HIV/AIDS-infection is given. Phosphazide is currently used in various regimens of highly active antiretroviral therapy, as well as in the HIV therapy in patients with simultaneously acquired chronic hepatitis C or tuberculosis. Therapeutic possibilities of Phosphazide were clearly manifested in the prevention of HIV transmission from mother to child. There is every reason to use Phosphazide in first-line antiretroviral therapy.
[Mh] Termos MeSH primário: Fármacos Anti-HIV/uso terapêutico
Infecções por HIV/tratamento farmacológico
HIV/efeitos dos fármacos
Transmissão Vertical de Doença Infecciosa/prevenção & controle
Organofosfonatos/uso terapêutico
Complicações Infecciosas na Gravidez/tratamento farmacológico
Zidovudina/análogos & derivados
[Mh] Termos MeSH secundário: Fármacos Anti-HIV/farmacocinética
Terapia Antirretroviral de Alta Atividade/métodos
Feminino
Feto
HIV/genética
HIV/metabolismo
Infecções por HIV/transmissão
Infecções por HIV/virologia
Seres Humanos
Organofosfonatos/farmacocinética
Gravidez
Complicações Infecciosas na Gravidez/virologia
Resultado do Tratamento
Zidovudina/farmacocinética
Zidovudina/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (3'-azido-2',3'-dideoxythymidine 5'-H-phoshonate); 0 (Anti-HIV Agents); 0 (Organophosphonates); 4B9XT59T7S (Zidovudine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE



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