Base de dados : MEDLINE
Pesquisa : A16.660 [Categoria DeCS]
Referências encontradas : 1459 [refinar]
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[PMID]:28744949
[Au] Autor:Leprévost A; Azaïs T; Trichet M; Sire JY
[Ad] Endereço:Sorbonne Universités, UPMC Univ Paris 06, Institut de Biologie Paris-Seine, CNRS, UMR7138-Department Evolution Paris Seine, Equipe 'Evolution et Développement du Squelette', Paris, France.
[Ti] Título:Identification of a new mineralized tissue in the notochord of reared Siberian sturgeon (Acipenser baerii).
[So] Source:J Morphol;278(11):1586-1597, 2017 Nov.
[Is] ISSN:1097-4687
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In a study aiming to improve knowledge on the mineralization of the axial skeleton in reared Siberian sturgeon (Acipenser baerii Brandt, 1869), we discovered a new mineralized tissue within the notochord. To our knowledge, such a structure has never been reported in any vertebrate species with the exception of the pathological mineralization of the notochord remains in degenerative intervertebral disks of mammals. Here, we describe this enigmatic tissue using X-ray microtomography, histological analyses and solid state NMR-spectroscopy. We also performed a 1-year monitoring of the mineral content (MC) of the notochord in relation with seasonal variations of temperature. In all specimens studied from 2-year-old juveniles onwards, this mineralized structure was found within a particular region of the notochord called funiculus. This feature first appears in the abdominal region then extends posteriorly with ageing, while the notochord MC also increases. The mineral phase is mainly composed of amorphous calcium phosphate, a small amount of which changes into hydroxyapatite with ageing. The putative role of this structure is discussed as either a store of minerals available for the phosphocalcic metabolism, or a mechanical support in a species with a poorly mineralized axial skeleton. A pathological feature putatively related to rearing conditions is also discussed.
[Mh] Termos MeSH primário: Calcificação Fisiológica/fisiologia
Peixes/fisiologia
Notocorda/fisiologia
[Mh] Termos MeSH secundário: Análise de Variância
Animais
Imagem Tridimensional
Espectroscopia de Ressonância Magnética
Minerais/metabolismo
Notocorda/diagnóstico por imagem
Notocorda/ultraestrutura
Microtomografia por Raio-X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Minerals)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180126
[Lr] Data última revisão:
180126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1002/jmor.20734


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[PMID]:28928284
[Au] Autor:Reeves WM; Wu Y; Harder MJ; Veeman MT
[Ad] Endereço:Division of Biology, Kansas State University, Manhattan, KS 66506, USA.
[Ti] Título:Functional and evolutionary insights from the notochord transcriptome.
[So] Source:Development;144(18):3375-3387, 2017 09 15.
[Is] ISSN:1477-9129
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The notochord of the ascidian consists of only 40 cells, and is a longstanding model for studying organogenesis in a small, simple embryo. Here, we perform RNAseq on flow-sorted notochord cells from multiple stages to define a comprehensive notochord transcriptome. We identify 1364 genes with enriched expression and extensively validate the results by hybridization. These genes are highly enriched for Gene Ontology terms related to the extracellular matrix, cell adhesion and cytoskeleton. Orthologs of 112 of the notochord genes have known notochord expression in vertebrates, more than twice as many as predicted by chance alone. This set of putative effector genes with notochord expression conserved from tunicates to vertebrates will be invaluable for testing hypotheses about notochord evolution. The full set of notochord genes provides a foundation for systems-level studies of notochord gene regulation and morphogenesis. We find only modest overlap between this set of notochord-enriched transcripts and the genes upregulated by ectopic expression of the key notochord transcription factor Brachyury, indicating that Brachyury is not a notochord master regulator gene as strictly defined.
[Mh] Termos MeSH primário: Evolução Biológica
Ciona intestinalis/embriologia
Ciona intestinalis/genética
Notocorda/embriologia
Notocorda/metabolismo
Transcriptoma/genética
[Mh] Termos MeSH secundário: Animais
Citoesqueleto/genética
Embrião não Mamífero/metabolismo
Matriz Extracelular/metabolismo
Proteínas Fetais/genética
Proteínas Fetais/metabolismo
Regulação da Expressão Gênica no Desenvolvimento
Ontologia Genética
Hibridização In Situ
Camundongos
Reprodutibilidade dos Testes
Análise de Sequência de RNA
Proteínas com Domínio T-Box/genética
Proteínas com Domínio T-Box/metabolismo
Peixe-Zebra/embriologia
Peixe-Zebra/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Brachyury protein); 0 (Fetal Proteins); 0 (T-Box Domain Proteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171126
[Lr] Data última revisão:
171126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170921
[St] Status:MEDLINE
[do] DOI:10.1242/dev.156174


  3 / 1459 MEDLINE  
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[PMID]:28606578
[Au] Autor:Miki K; Yoshimoto K; Nishimura A; Suzuki SO; Hiwatashi A; Iihara K
[Ad] Endereço:Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
[Ti] Título:A Case of Ecchordosis Physaliphora in the Prepontine Cistern: A Rare Entity in the Differential Diagnosis of an Epidermoid Cyst.
[So] Source:World Neurosurg;105:1033.e11-1033.e14, 2017 Sep.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Ecchordosis physaliphora (EP) is a benign notochordal remnant that is usually asymptomatic. We report a case of a symptomatic large EP mimicking an epidermoid cyst. CASE DESCRIPTION: A 44-year-old woman presented with right facial dysesthesia. Brain magnetic resonance imaging showed a mass with a diameter of 3.2 cm that was hypointense on T1-weighted imaging, hyperintense on T2-weighted imaging, isointense to hyperintense on diffusion-weighted imaging, and hyperintense on apparent diffusion coefficient map (1.2-1.6 × 10 mm /second). There was no apparent contrast enhancement. Differential diagnoses included epidermoid cyst, dermoid cyst, EP, chordoma, chondrosarcoma, neurenteric cyst, and arachnoid cyst. Clinicopathologic examination revealed that the mass was an EP. CONCLUSIONS: EP in the prepontine cistern should be considered in the differential diagnosis of epidermoid cyst.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/diagnóstico por imagem
Neoplasias Encefálicas/cirurgia
Cisto Epidérmico/diagnóstico por imagem
Cisto Epidérmico/cirurgia
Notocorda/diagnóstico por imagem
Notocorda/cirurgia
[Mh] Termos MeSH secundário: Adulto
Diagnóstico Diferencial
Feminino
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170614
[St] Status:MEDLINE


  4 / 1459 MEDLINE  
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[PMID]:28500182
[Au] Autor:Ishikawa T; Toyama T; Nakamura Y; Tamada K; Shimizu H; Ninagawa S; Okada T; Kamei Y; Ishikawa-Fujiwara T; Todo T; Aoyama E; Takigawa M; Harada A; Mori K
[Ad] Endereço:Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan.
[Ti] Título:UPR transducer BBF2H7 allows export of type II collagen in a cargo- and developmental stage-specific manner.
[So] Source:J Cell Biol;216(6):1761-1774, 2017 Jun 05.
[Is] ISSN:1540-8140
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The unfolded protein response (UPR) handles unfolded/misfolded proteins accumulated in the endoplasmic reticulum (ER). However, it is unclear how vertebrates correctly use the total of ten UPR transducers. We have found that ER stress occurs physiologically during early embryonic development in medaka fish and that the smooth alignment of notochord cells requires ATF6 as a UPR transducer, which induces ER chaperones for folding of type VIII (short-chain) collagen. After secretion of hedgehog for tissue patterning, notochord cells differentiate into sheath cells, which synthesize type II collagen. In this study, we show that this vacuolization step requires both ATF6 and BBF2H7 as UPR transducers and that BBF2H7 regulates a complete set of genes ( , , , and ) essential for the enlargement of COPII vesicles to accommodate long-chain collagen for export, leading to the formation of the perinotochordal basement membrane. Thus, the most appropriate UPR transducer is activated to cope with the differing physiological ER stresses of different content types depending on developmental stage.
[Mh] Termos MeSH primário: Fatores de Transcrição de Zíper de Leucina Básica/metabolismo
Vesículas Revestidas pelo Complexo de Proteína do Envoltório/metabolismo
Colágeno Tipo II/metabolismo
Proteínas de Peixes/metabolismo
Notocorda/metabolismo
Oryzias/metabolismo
Resposta a Proteínas não Dobradas
[Mh] Termos MeSH secundário: Fator 6 Ativador da Transcrição/genética
Fator 6 Ativador da Transcrição/metabolismo
Animais
Animais Geneticamente Modificados
Membrana Basal/metabolismo
Fatores de Transcrição de Zíper de Leucina Básica/genética
Vesículas Revestidas pelo Complexo de Proteína do Envoltório/secreção
Colágeno Tipo II/secreção
Embrião não Mamífero/metabolismo
Retículo Endoplasmático/metabolismo
Estresse do Retículo Endoplasmático
Proteínas de Peixes/genética
Regulação da Expressão Gênica no Desenvolvimento
Genótipo
Células HCT116
Seres Humanos
Notocorda/secreção
Oryzias/embriologia
Oryzias/genética
Fenótipo
Transporte Proteico
Fatores de Tempo
Transcrição Genética
Transfecção
Vacúolos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Activating Transcription Factor 6); 0 (Basic-Leucine Zipper Transcription Factors); 0 (CREB3L2 protein, human); 0 (Collagen Type II); 0 (Fish Proteins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170514
[St] Status:MEDLINE
[do] DOI:10.1083/jcb.201609100


  5 / 1459 MEDLINE  
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[PMID]:28153624
[Au] Autor:Fisahn C; Schmidt C; Rostad S; Li R; Rustagi T; Alonso F; Shoja MM; Iwanaga J; Chapman JR; Oskouian RJ; Tubbs RS
[Ad] Endereço:Swedish Neuroscience Institute, Swedish Medical Center, Seattle, Washington, USA; Seattle Science Foundation, Seattle, Washington, USA; Department of Trauma Surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, Germany. Electronic address: christian.fisahn@swedish.org.
[Ti] Título:Adult Apical Ligament of the Dens Lacks Notochordal Tissue: Application to Better Understanding the Origins of Skull Base Chordomas.
[So] Source:World Neurosurg;101:42-46, 2017 May.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The apical ligament has long been reported to contain notochord remnants and thus might serve as a site of origin of chordoma formation at the skull base. However, to our knowledge, the histologic study of the apical ligament using histologic staining specific for notochordal tissue has not been previously performed. Therefore the current study was undertaken. METHODS: Fifteen apical ligament samples underwent histologic examination with specific markers for notochordal differentiation. RESULTS: Across all samples, there was no indication of any notochordal remnants. CONCLUSIONS: On the basis of our cadaveric study, the apical ligament does not contain notochord tissue and in adults should not be considered a remnant of this structure. Moreover, it is unlikely that the apical ligament gives rise to chordomas at the craniocervical junction under normal circumstances.
[Mh] Termos MeSH primário: Cordoma/patologia
Ligamentos/patologia
Notocorda/patologia
Neoplasias da Base do Crânio/patologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170204
[St] Status:MEDLINE


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[PMID]:28144984
[Au] Autor:Criswell KE; Coates MI; Gillis JA
[Ad] Endereço:Department of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois.
[Ti] Título:Embryonic development of the axial column in the little skate, Leucoraja erinacea.
[So] Source:J Morphol;278(3):300-320, 2017 Mar.
[Is] ISSN:1097-4687
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The morphological patterns and molecular mechanisms of vertebral column development are well understood in bony fishes (osteichthyans). However, vertebral column morphology in elasmobranch chondrichthyans (e.g., sharks and skates) differs from that of osteichthyans, and its development has not been extensively studied. Here, we characterize vertebral development in an elasmobranch fish, the little skate, Leucoraja erinacea, using microCT, paraffin histology, and whole-mount skeletal preparations. Vertebral development begins with the condensation of mesenchyme, first around the notochord, and subsequently around the neural tube and caudal artery and vein. Mesenchyme surrounding the notochord differentiates into a continuous sheath of spindle-shaped cells, which forms the precursor to the mineralized areolar calcification of the centrum. Mesenchyme around the neural tube and caudal artery/vein becomes united by a population of mesenchymal cells that condenses lateral to the sheath of spindle-shaped cells, with this mesenchymal complex eventually differentiating into the hyaline cartilage of the future neural arches, hemal arches, and outer centrum. The initially continuous layers of areolar tissue and outer hyaline cartilage eventually subdivide into discrete centra and arches, with the notochord constricted in the center of each vertebra by a late-forming "inner layer" of hyaline cartilage, and by a ring of areolar calcification located medial to the outer vertebral cartilage. The vertebrae of elasmobranchs are distinct among vertebrates, both in terms of their composition (i.e., with centra consisting of up to three tissues layers-an inner cartilage layer, a calcified areolar ring, and an outer layer of hyaline cartilage), and their mode of development (i.e., the subdivision of arch and outer centrum cartilage from an initially continuous layer of hyaline cartilage). Given the evident variation in patterns of vertebral construction, broad taxon sampling, and comparative developmental analyses are required to understand the diversity of mechanisms at work in the developing axial skeleton of vertebrates. J. Morphol. 278:300-320, 2017. © 2017 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Desenvolvimento Embrionário
Raias/embriologia
Coluna Vertebral/embriologia
[Mh] Termos MeSH secundário: Animais
Calcificação Fisiológica
Cartilagem
Mesoderma
Notocorda/embriologia
Coluna Vertebral/anatomia & histologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170202
[St] Status:MEDLINE
[do] DOI:10.1002/jmor.20637


  7 / 1459 MEDLINE  
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[PMID]:28089818
[Au] Autor:Mehrkens A; Matta A; Karim MZ; Kim S; Fehlings MG; Schaeren S; Mark Erwin W
[Ad] Endereço:Krembil Research Institute, Toronto Western Hospital, 60 Leonard Ave, Toronto, Ontario M5T 2S8, Canada; Spine Surgery, University Hospital Basel, Spitalstr. 21, CH-4031 Basel, Switzerland.
[Ti] Título:Notochordal cell-derived conditioned medium protects human nucleus pulposus cells from stress-induced apoptosis.
[So] Source:Spine J;17(4):579-588, 2017 Apr.
[Is] ISSN:1878-1632
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND CONTEXT: Degenerative disc disease (DDD) remains without an effective therapy and presents a costly burden to society. PURPOSE: Based upon prior reports concerning the effects of notochordal cell-conditioned medium (NCCM) on disc cells, we performed a proof of principle study to determine whether NCCM could reduce cytotoxic stress-induced apoptosis in human disc nucleus pulposus (NP) cells. STUDY DESIGN/SETTING: This is an "in vitro" fundamental or basic science study. METHODS: Nucleus pulpous cells derived from 15 patients undergoing spinal surgery were treated with interleukin (IL)-1ß and Fas ligand or etoposide in the presence of NCCM. We determined pro- or antiapoptotic events using activated caspase assays and determined genomic regulation of apoptosis using polymerase chain reaction arrays validated using Western blotting methods. We interrogated cellular apoptotic regulation using JC-1 dye and flow cytometry and performed enzyme-linked immunosorbent assays to evaluate NP inflammatory cytokine secretion. RESULTS: Notochordal cell-conditioned medium inhibits cytotoxic stress-induced caspase-9 and -3/7 activities and maintains the mitochondrial membrane potential in human NP cells, thereby suppressing the intrinsic apoptotic pathway. Gene expression analysis revealed the X-linked inhibitor of apoptosis protein as a key player responsible for evading etoposide-induced apoptosis in the presence of NCCM, and we verified these data using Western blotting. Enzyme-linked immunosorbent assay results revealed distinct differences in IL-6 and IL-8 secretions by NP cells in response to etoposide in the presence of NCCM. CONCLUSIONS: Here we demonstrate for the first time that NCCM reduces cytotoxic stress-induced apoptosis in human NP cells. Soluble factors present in NCCM could be harnessed for the development of novel therapeutics for the treatment of DDD.
[Mh] Termos MeSH primário: Apoptose
Notocorda/metabolismo
Núcleo Pulposo/citologia
[Mh] Termos MeSH secundário: Células Cultivadas
Meios de Cultivo Condicionados/farmacologia
Proteína Ligante Fas/metabolismo
Seres Humanos
Interleucina-6/metabolismo
Interleucina-8/metabolismo
Notocorda/citologia
Núcleo Pulposo/efeitos dos fármacos
Proteínas Inibidoras de Apoptose Ligadas ao Cromossomo X/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Culture Media, Conditioned); 0 (FASLG protein, human); 0 (Fas Ligand Protein); 0 (Interleukin-6); 0 (Interleukin-8); 0 (X-Linked Inhibitor of Apoptosis Protein); 0 (XIAP protein, human)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170117
[St] Status:MEDLINE


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[PMID]:28017643
[Au] Autor:Taniguchi Y; Kurth T; Weiche S; Reichelt S; Tazaki A; Perike S; Kappert V; Epperlein HH
[Ad] Endereço:Department of Anatomy, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany; Center for Regenerative Therapies, Technische Universität Dresden, Fetscherstrasse 105, 01307 Dresden, Germany; Research Institute for Molecular Pathology (IMP), Campus-Vienna-Biocenter 1, 1030 Vienna,
[Ti] Título:The posterior neural plate in axolotl gives rise to neural tube or turns anteriorly to form somites of the tail and posterior trunk.
[So] Source:Dev Biol;422(2):155-170, 2017 02 15.
[Is] ISSN:1095-564X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Classical grafting experiments in the Mexican axolotl had shown that the posterior neural plate of the neurula is no specified neuroectoderm but gives rise to somites of the tail and posterior trunk. The bipotentiality of this region with neuromesodermal progenitor cell populations was revealed more recently also in zebrafish, chick, and mouse. We reinvestigated the potency of the posterior plate in axolotl using grafts from transgenic embryos, immunohistochemistry, and in situ hybridization. The posterior plate is brachyury-positive except for its more anterior parts which express sox2. Between anterior and posterior regions of the posterior plate a small domain with sox2+ and bra+ cells exists. Lineage analysis of grafted GFP-labeled posterior plate tissue revealed that posterior GFP+ cells move from dorsal to ventral, form the posterior wall, turn anterior bilaterally, and join the gastrulated paraxial presomitic mesoderm. More anterior sox2+/GFP+ cells, however, are integrated into the developing spinal cord. Tail notochord is formed from axial mesoderm involuted already during gastrulation. Thus the posterior neural plate is a postgastrula source of paraxial mesoderm, which performs an anterior turn, a novel morphogenetic movement. More anterior plate cells, in contrast, do not turn anteriorly but become specified to form tail spinal cord.
[Mh] Termos MeSH primário: Ambystoma mexicanum/embriologia
Mesoderma/embriologia
Placa Neural/embriologia
Tubo Neural/embriologia
Medula Espinal/embriologia
Cauda/embriologia
[Mh] Termos MeSH secundário: Animais
Animais Geneticamente Modificados
Células Cultivadas
Proteínas Fetais/metabolismo
Gastrulação/fisiologia
Proteínas de Fluorescência Verde/genética
Notocorda/embriologia
Fatores de Transcrição SOXB1/biossíntese
Somitos/embriologia
Células-Tronco/citologia
Proteínas com Domínio T-Box/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Brachyury protein); 0 (Fetal Proteins); 0 (SOXB1 Transcription Factors); 0 (T-Box Domain Proteins); 147336-22-9 (Green Fluorescent Proteins)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171120
[Lr] Data última revisão:
171120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161227
[St] Status:MEDLINE


  9 / 1459 MEDLINE  
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[PMID]:27993982
[Au] Autor:Yu T; Graf M; Renn J; Schartl M; Larionova D; Huysseune A; Witten PE; Winkler C
[Ad] Endereço:Department of Biological Sciences, National University of Singapore, Singapore 117543, Singapore.
[Ti] Título:A vertebrate-specific and essential role for osterix in osteogenesis revealed by gene knockout in the teleost medaka.
[So] Source:Development;144(2):265-271, 2017 01 15.
[Is] ISSN:1477-9129
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:osterix (osx; sp7) encodes a zinc-finger transcription factor that controls osteoblast differentiation in mammals. Although identified in all vertebrate lineages, its role in non-mammalian bone formation remains elusive. Here, we show that an osx mutation in medaka results in severe bone defects and larval lethality. Pre-osteoblasts fail to differentiate leading to severe intramembranous and perichondral ossification defects. The notochord sheath mineralizes normally, supporting the idea of an osteoblast-independent mechanism for teleost vertebral centra formation. This study establishes a key role for Osx for bone formation in a non-mammalian species, and reveals conserved and non-conserved features in vertebrate bone formation.
[Mh] Termos MeSH primário: Oryzias/embriologia
Oryzias/genética
Osteogênese/genética
Fatores de Transcrição/fisiologia
[Mh] Termos MeSH secundário: Animais
Animais Geneticamente Modificados
Calcificação Fisiológica/genética
Regulação da Expressão Gênica no Desenvolvimento
Técnicas de Inativação de Genes
Notocorda/embriologia
Filogenia
Fator de Transcrição Sp7
Especificidade da Espécie
Fatores de Transcrição/genética
Vertebrados/embriologia
Vertebrados/genética
Proteínas de Peixe-Zebra/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Osterix protein, zebrafish); 0 (Sp7 Transcription Factor); 0 (Transcription Factors); 0 (Zebrafish Proteins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161221
[St] Status:MEDLINE
[do] DOI:10.1242/dev.139550


  10 / 1459 MEDLINE  
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[PMID]:27975274
[Au] Autor:Houston DW
[Ad] Endereço:Department of Biology, The University of Iowa, 257 BB, Iowa City, IA, 52242, USA. douglas-houston@uiowa.edu.
[Ti] Título:Vertebrate Axial Patterning: From Egg to Asymmetry.
[So] Source:Adv Exp Med Biol;953:209-306, 2017.
[Is] ISSN:0065-2598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The emergence of the bilateral embryonic body axis from a symmetrical egg has been a long-standing question in developmental biology. Historical and modern experiments point to an initial symmetry-breaking event leading to localized Wnt and Nodal growth factor signaling and subsequent induction and formation of a self-regulating dorsal "organizer." This organizer forms at the site of notochord cell internalization and expresses primarily Bone Morphogenetic Protein (BMP) growth factor antagonists that establish a spatiotemporal gradient of BMP signaling across the embryo, directing initial cell differentiation and morphogenesis. Although the basics of this model have been known for some time, many of the molecular and cellular details have only recently been elucidated and the extent that these events remain conserved throughout vertebrate evolution remains unclear. This chapter summarizes historical perspectives as well as recent molecular and genetic advances regarding: (1) the mechanisms that regulate symmetry-breaking in the vertebrate egg and early embryo, (2) the pathways that are activated by these events, in particular the Wnt pathway, and the role of these pathways in the formation and function of the organizer, and (3) how these pathways also mediate anteroposterior patterning and axial morphogenesis. Emphasis is placed on comparative aspects of the egg-to-embryo transition across vertebrates and their evolution. The future prospects for work regarding self-organization and gene regulatory networks in the context of early axis formation are also discussed.
[Mh] Termos MeSH primário: Padronização Corporal/genética
Gastrulação/genética
Morfogênese/genética
Vertebrados/embriologia
[Mh] Termos MeSH secundário: Animais
Proteínas Morfogenéticas Ósseas/genética
Proteínas Morfogenéticas Ósseas/metabolismo
Regulação da Expressão Gênica no Desenvolvimento/genética
Notocorda/embriologia
Transdução de Sinais/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Bone Morphogenetic Proteins)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161216
[St] Status:MEDLINE



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