Base de dados : MEDLINE
Pesquisa : A16.690.325 [Categoria DeCS]
Referências encontradas : 4361 [refinar]
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  1 / 4361 MEDLINE  
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[PMID]:29187161
[Au] Autor:Wu YQ; Qu YF; Wang XJ; Gao JF; Ji X
[Ad] Endereço:Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu, 210023, China.
[Ti] Título:Does the oviparity-viviparity transition alter the partitioning of yolk in embryonic snakes?
[So] Source:BMC Evol Biol;17(1):235, 2017 Nov 29.
[Is] ISSN:1471-2148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The oviparity-viviparity transition is a major evolutionary event, likely altering the reproductive process of the organisms involved. Residual yolk, a portion of yolk remaining unutilized at hatching or birth as parental investment in care, has been investigated in many oviparous amniotes but remained largely unknown in viviparous species. Here, we used data from 20 (12 oviparous and 8 viviparous) species of snakes to see if the oviparity-viviparity transition alters the partitioning of yolk in embryonic snakes. We used ANCOVA to test whether offspring size, mass and components at hatching or birth differed between the sexes in each species. We used both ordinary least squares and phylogenetic generalized least squares regressions to test whether relationships between selected pairs of offspring components were significant. We used phylogenetic ANOVA to test whether offspring components differed between oviparous and viviparous species and, more specifically, the hypothesis that viviparous snakes invest more in the yolk as parental investment in embryogenesis to produce more well developed offspring that are larger in linear size. RESULTS: In none of the 20 species was sex a significant source of variation in any offspring component examined. Newborn viviparous snakes on average contained proportionally more water and, after accounting for body dry mass, had larger carcasses but smaller residual yolks than did newly hatched oviparous snakes. The rates at which carcass dry mass (CDM) and fat body dry mass (FDM) increased with residual yolk dry mass (YDM) did not differ between newborn oviparous and viviparous snakes. Neither CDM nor FDM differed between newborn oviparous and viviparous snakes after accounting for YDM. CONCLUSIONS: Our results are not consistent with the hypothesis that the partitioning of yolk between embryonic and post-embryonic stages differs between snakes that differ in parity mode, but instead show that the partitioning of yolk in embryonic snakes is species-specific or phylogenetically related. We conclude that the oviparity-viviparity transition does not alter yolk partitioning in embryonic snakes.
[Mh] Termos MeSH primário: Gema de Ovo/fisiologia
Embrião não Mamífero/fisiologia
Oviparidade/fisiologia
Serpentes/embriologia
Viviparidade não Mamífera/fisiologia
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Feminino
Filogenia
Análise de Regressão
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1186/s12862-017-1083-z


  2 / 4361 MEDLINE  
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[PMID]:29441971
[Au] Autor:Rutkowska M; Slupski W; Trocha M; Szandruk M; Rymaszewska J
[Ti] Título:The anxiolytic activity of n-3 PUFAs enriched egg yolk phospholipids in rat behavioral studies.
[So] Source:Pharmazie;71(11):655-659, 2016 11 02.
[Is] ISSN:0031-7144
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Phospholipids play an important role in the biochemical and physiological processes of cells. An association between disturbed phospholipids metabolism in neuronal tissue and anxiety it was shown. The aim of this study was to examine the anxiolytic properties of phospholipids obtained from a new generation of eggs enriched in n-3 PUFA and its effect on locomotor activity in rat behavioral studies N-3 PUFA-enriched egg yolk phospholipids ("super lecithin") were added to the standard feed. Rats were fed by chow without (control group) or with (experimental group) addition of phospholipids. After six weeks of supplementation, the effect of phospholipids on locomotor activity in the open field test and anxiolytic properties in elevated plus maze and Vogel conflict test were examined. In the open field test the total distance traveled in the experimental group was similar to the control group. In the elevated plus maze test a six weeks phospholipids' administration significantly prolonged the time spent on the open arms by rats from experimental group compared to control group. The number of entries into the open arms was also increased but the difference was not statistically significant. The number of punished drinking water in the Vogel conflict test increased significantly in experimental versus control group. The obtained results suggest that the phospholipids isolated from n-3 PUFA enriched egg yolk have a specific anxiolytic effect, without general sedative influence.
[Mh] Termos MeSH primário: Ansiolíticos/farmacologia
Comportamento Animal/efeitos dos fármacos
Gema de Ovo/química
Ácidos Graxos Ômega-3/farmacologia
Fosfolipídeos/farmacologia
[Mh] Termos MeSH secundário: Animais
Conflito (Psicologia)
Comportamento Exploratório/efeitos dos fármacos
Masculino
Atividade Motora/efeitos dos fármacos
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Anxiety Agents); 0 (Fatty Acids, Omega-3); 0 (Phospholipids)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1691/ph.2016.6646


  3 / 4361 MEDLINE  
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[PMID]:29311523
[Au] Autor:Uyama M; Inoue K; Kinoshita K; Miyahara R; Yokoyama H; Nakano M
[Ad] Endereço:Shiseido Global Innovation Center.
[Ti] Título:Effect of Dialkyl Ammonium Cationic Surfactants on the Microfluidity of Membranes Containing Raft Domains.
[So] Source:J Oleo Sci;67(1):67-75, 2018.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:It has been reported that a lot of receptors localize in lipid raft domains and that the microfluidity of these domains regulates the activation of these receptors. In this study, we focused on the lipid raft and in order to evaluate the physicochemical effects of surfactants on microfluidity of lipid membranes, we used liposomes comprising of egg-yolk L-α-phosphatidylcholine, egg-yolk sphingomyelin, and cholesterol as a model of cell membranes containing raft domains. The microfluidity of the domains was characterized by fluorescence spectrometry using 1,6-diphenyl-1,3,5-hexatriene and 2-dimethylamino-6-lauroylnaphthalene. Among several surfactants, dialkylammonium-type cationic surfactants most efficiently increased the microfluidity. It is therefore concluded that (1) the electrostatic interaction between the cationic surfactant and eggPC/eggSM/cholesterol liposome could be important, (2) surfactants with alkyl chains more effectively inserted into membranes than those with acyl chains, and (3) cationic surfactants with lower T values have a greater ability to increase the fluidity.
[Mh] Termos MeSH primário: Compostos de Amônio
Membrana Celular
Fluidez de Membrana
Lipídeos de Membrana
Microdomínios da Membrana
Tensoativos
[Mh] Termos MeSH secundário: Cátions
Fenômenos Químicos
Colesterol
Gema de Ovo
Lipossomos
Fosfatidilcolinas
Espectrometria de Fluorescência
Esfingomielinas
Eletricidade Estática
Tensoativos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ammonium Compounds); 0 (Cations); 0 (Liposomes); 0 (Membrane Lipids); 0 (Phosphatidylcholines); 0 (Sphingomyelins); 0 (Surface-Active Agents); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess17124


  4 / 4361 MEDLINE  
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[PMID]:29364913
[Au] Autor:Mellouk N; Ramé C; Marchand M; Staub C; Touzé JL; Venturi É; Mercerand F; Travel A; Chartrin P; Lecompte F; Ma L; Froment P; Dupont J
[Ad] Endereço:INRA UMR85 Physiologie de la Reproduction et des Comportements, Nouzilly, France.
[Ti] Título:Effect of different levels of feed restriction and fish oil fatty acid supplementation on fat deposition by using different techniques, plasma levels and mRNA expression of several adipokines in broiler breeder hens.
[So] Source:PLoS One;13(1):e0191121, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Reproductive hens are subjected to a restricted diet to limit the decline in fertility associated with change in body mass. However, endocrine and tissue responses to diet restriction need to be documented. OBJECTIVE: We evaluated the effect of different levels of feed restriction, with or without fish oil supplementation, on metabolic parameters and adipokine levels in plasma and metabolic tissues of reproductive hens. METHODS: We designed an in vivo protocol involving 4 groups of hens; RNS: restricted (Rt) unsupplemented, ANS: ad libitum (Ad, receiving an amount of feed 1.7 times greater than animals on the restricted diet) unsupplemented, RS: Rt supplemented, and AS: Ad supplemented. The fish oil supplement was used at 1% of the total diet composition. RESULTS: Hens fed with the Rt diet had a significantly (P < 0.0001) lower growth than Ad hens, while the fish oil supplementation had no effect on these parameters. Furthermore, the bioelectrical impedance analysis (BIA) and the fat ultrasonographic examinations produced similar results to the other methods that required animals to be killed (carcass analysis and weight of adipose tissue). In addition, the Rt diet significantly (P < 0.05) decreased plasma levels of triglycerides, phospholipids, glucose and ADIPOQ, and fish oil supplementation decreased plasma levels of RARRES2. We also showed a positive correlation between insulin values and ADIPOQ or NAMPT or RARRES2 values, and a negative correlation of fat percentage to RARRES2 values. Moreover, the effects of the Rt diet and fish oil supplementation on the mRNA expression depended on the factors tested and the hen age. CONCLUSIONS: Rt diet and fish oil supplementation are able to modulate metabolic parameters and the expression of adipokines and their receptors in metabolic tissue.
[Mh] Termos MeSH primário: Adipocinas/sangue
Ração Animal
Restrição Calórica
Ácidos Graxos/administração & dosagem
Óleos de Peixe/administração & dosagem
RNA Mensageiro/genética
[Mh] Termos MeSH secundário: Adipocinas/genética
Animais
Galinhas
Gema de Ovo/metabolismo
Ácidos Graxos/metabolismo
Feminino
Fígado/metabolismo
Músculos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Adipokines); 0 (Fatty Acids); 0 (Fish Oils); 0 (RNA, Messenger)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191121


  5 / 4361 MEDLINE  
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[PMID]:29220173
[Au] Autor:Primacella M; Wang T; Acevedo NC
[Ad] Endereço:Department of Food Science and Human Nutrition, Iowa State University , 2312 Food Sciences Building, 536 Farm House Lane, Ames, Iowa 5011, United States.
[Ti] Título:Use of Reconstitued Yolk Systems To Study the Gelation Mechanism of Frozen-Thawed Hen Egg Yolk.
[So] Source:J Agric Food Chem;66(2):512-520, 2018 Jan 17.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Yolk gelation upon 5 week freezing-thawing was studied in four recombined yolk systems containing different plasma and granule proportions. Fractionation for mass distribution, sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) for protein distribution, and rheological properties were explored. Results indicate that both plasma and granule components, including low-density lipoprotein (LDL), high-density lipoprotein (HDL), and α-livetin proteins, contributed to gelation. Protein aggregation was reflected through a large mass increase in the granule fraction and appearance of a floating LDL layer upon fractionation of gelated yolk systems. A significant increase in gel strength (elastic modulus, G') was observed with the increase of the granule content. Overall, this study provides a better understanding of yolk gelation mechanism that may consequently lead to the design of innovative methods for preventing gelation. A schematic presentation of the yolk gelation mechanism is also proposed.
[Mh] Termos MeSH primário: Gema de Ovo/química
[Mh] Termos MeSH secundário: Animais
Galinhas
Proteínas do Ovo/química
Eletroforese em Gel de Poliacrilamida
Feminino
Géis/química
Lipoproteínas HDL/química
Lipoproteínas LDL/química
Peso Molecular
Reologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Egg Proteins); 0 (Gels); 0 (Lipoproteins, HDL); 0 (Lipoproteins, LDL); 9008-28-0 (livetin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04370


  6 / 4361 MEDLINE  
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[PMID]:29208016
[Au] Autor:Thibodeau A; Fravalo P; Perron A; Lewandowski SL; Letellier A
[Ad] Endereço:Chaire de recherche industrielle du CRSNG en salubrité des viandes, Faculté de médecine vétérinaire, Université de Montréal, 3200 rue Sicotte, Saint-Hyacinthe, QUÉBEC, Canada.
[Ti] Título:Production and characterization of anti-Campylobacter jejuni IgY derived from egg yolks.
[So] Source:Acta Vet Scand;59(1):80, 2017 Dec 06.
[Is] ISSN:1751-0147
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Campylobacter jejuni is a major cause of foodborne disease having chickens as an important reservoir. Its control at the farm would lower the contamination of the final products and therefore also lower the risk of transmission to humans. At the farm, C. jejuni is rarely found in chickens before they reach 2 weeks of age. Past studies have shown that maternal antibodies could hamper C. jejuni gut colonization. The objective of this study was to compare protocols to use in order to produce anti-C. jejuni antibodies derived from egg yolks in the perspective to be used as feed additives for the control of chicken C. jejuni colonization. Laying hens were naturally contaminated with four well-characterized strains or injected with either outer membrane proteins or formalin-killed whole bacteria derived from these same strains. Eggs were collected and IgYs present in the yolks were extracted. The amount and the specificity of the recovered antibodies were characterized. RESULTS: It was observed that injection yielded eggs with superior concentrations of both total and anti-C. jejuni antibodies. Equivalent performances for antibodies recovered from all protocols were observed for the ability of the antibodies to agglutinate the live C. jejuni homologous strains, to hinder their motility or to lyse the bacteria. Western blot analyses showed that proteins from all strains could be recognized by all IgY extracts. All these characteristics were strain specific. The characterization assays were also made for heterologous strains and weaker results were observed when compared to the homologous strains. CONCLUSIONS: Based on these results, only an IgY quantitative based selection can be made in regards to which protocol would give the best anti-C. jejuni IgY enriched egg-yolks as all tested protocols were equivalent in terms of the recovered antibody ability to recognized the tested C. jejuni strains.
[Mh] Termos MeSH primário: Infecções por Campylobacter/veterinária
Gema de Ovo
Imunoglobulinas/biossíntese
Imunoglobulinas/imunologia
Doenças das Aves Domésticas/prevenção & controle
[Mh] Termos MeSH secundário: Animais
Proteínas de Bactérias/metabolismo
Infecções por Campylobacter/imunologia
Infecções por Campylobacter/prevenção & controle
Campylobacter jejuni/imunologia
Galinhas
Gema de Ovo/imunologia
Feminino
Doenças das Aves Domésticas/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (IgY); 0 (Immunoglobulins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE
[do] DOI:10.1186/s13028-017-0346-4


  7 / 4361 MEDLINE  
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[PMID]:29267387
[Au] Autor:Ma L; Sun K; Tu K; Pan L; Zhang W
[Ad] Endereço:College of Food Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu, People's Republic of China.
[Ti] Título:Identification of double-yolked duck egg using computer vision.
[So] Source:PLoS One;12(12):e0190054, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The double-yolked (DY) egg is quite popular in some Asian countries because it is considered as a sign of good luck, however, the double yolk is one of the reasons why these eggs fail to hatch. The usage of automatic methods for identifying DY eggs can increase the efficiency in the poultry industry by decreasing egg loss during incubation or improving sale proceeds. In this study, two methods for DY duck egg identification were developed by using computer vision technology. Transmittance images of DY and single-yolked (SY) duck eggs were acquired by a CCD camera to identify them according to their shape features. The Fisher's linear discriminant (FLD) model equipped with a set of normalized Fourier descriptors (NFDs) extracted from the acquired images and the convolutional neural network (CNN) model using primary preprocessed images were built to recognize duck egg yolk types. The classification accuracies of the FLD model for SY and DY eggs were 100% and 93.2% respectively, while the classification accuracies of the CNN model for SY and DY eggs were 98% and 98.8% respectively. The CNN-based algorithm took about 0.12 s to recognize one sample image, which was slightly faster than the FLD-based (about 0.20 s). Finally, this work compared two classification methods and provided the better method for DY egg identification.
[Mh] Termos MeSH primário: Computadores
Gema de Ovo
[Mh] Termos MeSH secundário: Algoritmos
Animais
Patos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190054


  8 / 4361 MEDLINE  
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[PMID]:28873642
[Au] Autor:Zhou M; Khen K; Wang T; Hu Q; Xue J; Luo Y
[Ad] Endereço:Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA.
[Ti] Título:Chemical crosslinking improves the gastrointestinal stability and enhances nutrient delivery potentials of egg yolk LDL/polysaccharide nanogels.
[So] Source:Food Chem;239:840-847, 2018 Jan 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Egg yolk low density lipoprotein (LDL)/polysaccharide nanogels are newly explored as oral delivery systems with promising encapsulation potentials. Nonetheless, the stability of nanogels against aggregation in gastrointestinal tract remains a challenge. Therefore, chemical crosslinking by 1-ethyl-3-(3-dimethylaminopropyl) and carbodiimide/N-hydroxysuccinimide (EDC/NHS) was adopted to improve the gastrointestinal stability of nanogels. Compared to original uncrosslinked nanogels, crosslinking did not change particle size, polydispersity index (PDI) and morphology, but it reduced surface charge of nanogels. The nano spray dried LDL/CMC/EDC nanogels had relatively poor surface structure with agglomerations. The FT-IR spectra confirmed the formation of new peptide bonds, which significantly improved stability of nanogels under simulated gastrointestinal conditions. Fluorescence spectra evidenced that non-polar microenvironment for curcumin embedded in nanogels was strengthened, which therefore enhanced encapsulation efficiency. Moreover, curcumin exhibited sustained release profile from crosslinked nanogels in simulated gastrointestinal fluids. Overall, our study provided a promising strategy to enhance the stability of LDL-based nanogels in digestive conditions.
[Mh] Termos MeSH primário: Gema de Ovo
[Mh] Termos MeSH secundário: Polietilenoglicóis
Polietilenoimina
Polissacarídeos
Espectroscopia de Infravermelho com Transformada de Fourier
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (NanoGel); 0 (Polysaccharides); 30IQX730WE (Polyethylene Glycols); 9002-98-6 (Polyethyleneimine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE


  9 / 4361 MEDLINE  
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[PMID]:28928283
[Au] Autor:Shao M; Wang M; Liu YY; Ge YW; Zhang YJ; Shi DL
[Ad] Endereço:School of Life Science, Shandong University, 27 Shanda Nan road, Jinan 250100, China.
[Ti] Título:Vegetally localised Vrtn functions as a novel repressor to modulate transcription during dorsoventral patterning in zebrafish.
[So] Source:Development;144(18):3361-3374, 2017 09 15.
[Is] ISSN:1477-9129
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The vegetal pole cytoplasm represents a crucial source of maternal dorsal determinants for patterning the dorsoventral axis of the early embryo. Removal of the vegetal yolk in the zebrafish fertilised egg before the completion of the first cleavage results in embryonic ventralisation, but removal of this part at the two-cell stage leads to embryonic dorsalisation. How this is achieved remains unknown. Here, we report a novel mode of maternal regulation of BMP signalling during dorsoventral patterning in zebrafish. We identify Vrtn as a novel vegetally localised maternal factor with dorsalising activity and rapid transport towards the animal pole region after fertilisation. Co-injection of mRNA with vegetal RNAs from different cleavage stages suggests the presence of putative vegetally localised Vrtn antagonists with slower animal pole transport. Thus, vegetal ablation at the two-cell stage could remove most of the Vrtn antagonists, and allows Vrtn to produce the dorsalising effect. Mechanistically, Vrtn binds a regulatory sequence and acts as a repressor to inhibit its zygotic transcription. Analysis of maternal-zygotic mutants further shows that Vrtn is required to constrain excessive expression in the margin. Our work unveils a novel maternal mechanism regulating zygotic BMP gradient in dorsoventral patterning.
[Mh] Termos MeSH primário: Padronização Corporal
Proteína Morfogenética Óssea 2/genética
Gema de Ovo/metabolismo
Proteínas Repressoras/metabolismo
Proteínas de Peixe-Zebra/metabolismo
Peixe-Zebra/embriologia
[Mh] Termos MeSH secundário: Animais
Sequência de Bases
Padronização Corporal/genética
Proteína Morfogenética Óssea 2/metabolismo
Células COS
Cercopithecus aethiops
Embrião não Mamífero/citologia
Embrião não Mamífero/metabolismo
Regulação da Expressão Gênica no Desenvolvimento
Modelos Biológicos
Mutação/genética
Ligação Proteica/genética
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Proteínas Repressoras/genética
Transcrição Genética
Via de Sinalização Wnt/genética
Peixe-Zebra/genética
Proteínas de Peixe-Zebra/genética
Zigoto/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bone Morphogenetic Protein 2); 0 (RNA, Messenger); 0 (Repressor Proteins); 0 (Zebrafish Proteins); 0 (bmp2b protein, zebrafish); 0 (vertnin protein, zebrafish)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171126
[Lr] Data última revisão:
171126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170921
[St] Status:MEDLINE
[do] DOI:10.1242/dev.152553


  10 / 4361 MEDLINE  
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[PMID]:28844670
[Au] Autor:Zhong H; Luo Y; Sun J; Wang C; Wang QG; Gao GL; Zhang KS; Li Q; Wang HW; Li J; Chen MJ; Wang YM; Zhao XZ
[Ad] Endereço:Chongqing Academy of Animal Sciences, Chongqing, PR China; Chongqing Engineering Research Center of Goose Genetic Improvement, Chongqing, PR China.
[Ti] Título:Goose FMO3 gene cloning, tissue expression profiling, polymorphism detection and association analysis with trimethylamine level in the egg yolk.
[So] Source:Gene;632:25-35, 2017 Oct 20.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Flavin-containing monooxygenase 3 (FMO3) plays a critical role in catalyzing the conversion of trimethylamine (TMA) to trimethylamine-N-oxide (TMAO) in vivo. Despite the well-documented association between FMO3 mutations and a 'fishy' off-flavor eggs in chicken and quail, little information is available regarding the molecular characteristic of goose (Anser cygnoides) FMO3 and its relationship with the yolk TMA content. To fill these gaps, we cloned the full-length cDNA sequence of goose FMO3, which comprised 1851bp encoding 531 amino acids. FMO3 mRNA was dramatically expressed in liver than in other tissues in the geese. Eight single nucleotide polymorphisms (SNPs) were detected in the entire coding region. The CC genotype at the T669C site, GG at the A723G site, and AA at the G734A site of FMO3 were highly significantly associated with elevated TMA content in goose egg yolk (P<0.001). Carriers of the A allele of G734A or C allele of T885C had yolk TMA content that had a high probability of being elevated after feeding with additional choline chloride (P=0.0429, OR=4.1300, 95%CI=1.0390-16.4270, and P=0.0251, OR=4.6060, 95%CI=1.1620-18.2620, respectively). This work lays a foundation for studying the function of FMO3 and yolk TMA content in goose. However, studies using larger sample sizes and more goose breeds are required to determine whether the fishy off-flavor trait exists in goose.
[Mh] Termos MeSH primário: Proteínas Aviárias/genética
Gema de Ovo/metabolismo
Gansos/genética
Metilaminas/metabolismo
Oxigenases/genética
Polimorfismo Genético
[Mh] Termos MeSH secundário: Animais
Proteínas Aviárias/metabolismo
Clonagem Molecular
Ovos/análise
Ovos/normas
Mutação de Sentido Incorreto
Oxigenases/metabolismo
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Avian Proteins); 0 (Methylamines); 0 (RNA, Messenger); EC 1.13.- (Oxygenases); EC 1.14.13.8 (dimethylaniline monooxygenase (N-oxide forming)); LHH7G8O305 (trimethylamine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170829
[St] Status:MEDLINE



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