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[PMID]:29489649
[Au] Autor:Xu R; Chen C; Zhou Y; Zhang X; Wan Y
[Ad] Endereço:Department of Clinical Nutrition, Ren Ji Hospital, School of Medicine.
[Ti] Título:Fingernail selenium levels in relation to the risk of obesity in Chinese children: A cross-sectional study.
[So] Source:Medicine (Baltimore);97(9):e0027, 2018 Mar.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Selenium (Se) has been suggested to be beneficial to obesity development. However, limited studies have evaluated the association between Se and childhood obesity and the findings are inconsistent.The aim of this study was to examine the association of Se levels with obesity in children in a cross-sectional study.A total of 62 obese (21 girls) and 65 normal-weight children (27 girls) aged 7 to 13 years were recruited in Shanghai, China. Obesity was defined as body mass index (BMI) ≥ its 95th age- and sex-specific percentile for children. Participant demographic data and parental information were obtained through a self-administered questionnaire. Se concentration in fingernail clippings was quantified using flame atomic absorption spectrophotometry.The average age was 10.9 years (standard deviation = 1.0) and the mean BMI was 21.2 kg/m (standard deviation = 5.0). Fingernail Se levels were relatively higher among normal-weight children as compared with obese participants, though the difference was not statistically significant (P = .79). Se levels were inversely associated with the risk of childhood obesity after adjustment for potential confounders. The multivariable-adjusted odds ratio (95% confidence interval) was 0.24 (0.07-0.84) comparing participants in the highest with those who in the lowest tertile of Se levels (Plinear-trend = .03).Our study supported an inverse association between fingernail Se levels and the risk of obesity in Chinese children. Data generated from the present study are useful for designing future prospective cohort studies and/or randomized clinical trials.
[Mh] Termos MeSH primário: Unhas/metabolismo
Obesidade Pediátrica/epidemiologia
Obesidade Pediátrica/metabolismo
Selênio/metabolismo
[Mh] Termos MeSH secundário: Adolescente
Criança
China/epidemiologia
Estudos Transversais
Seres Humanos
Masculino
Fatores de Risco
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
H6241UJ22B (Selenium)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180301
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000010027


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[PMID]:28461527
[Au] Autor:Cunha JS; Qureshi AA; Reginato AM
[Ad] Endereço:From the Division of Rheumatology, and Division of Dermatology, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA. Joanne_szczygiel@brown.edu.
[Ti] Título:Nail Enthesis Ultrasound in Psoriasis and Psoriatic Arthritis: A Report from the 2016 GRAPPA Annual Meeting.
[So] Source:J Rheumatol;44(5):688-690, 2017 May.
[Is] ISSN:0315-162X
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:Musculoskeletal ultrasonography is gaining favor in the evaluation of enthesitis in patients with psoriasis and psoriatic arthritis (PsA). Imaging modalities have shown that the enthesis of the distal interphalangeal joint has a close relationship to the nail itself. Studies have focused on the structure and morphology of nails to determine an association between psoriasis nail changes and the presence or severity of PsA. With the use of higher frequency probes, power Doppler (PD) can determine subclinical inflammation of the area under ultrasound examination. At the 2016 meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA), we proposed an ultrasonographic index for the assessment of the nail enthesis to identify the morphologic and PD findings of the nail, with the potential that both rheumatologists and dermatologists can use it to evaluate their patients.
[Mh] Termos MeSH primário: Artrite Psoriásica/diagnóstico por imagem
Entesopatia/diagnóstico por imagem
Unhas/diagnóstico por imagem
Psoríase/diagnóstico por imagem
Ultrassonografia
[Mh] Termos MeSH secundário: Seres Humanos
Índice de Gravidade de Doença
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.3899/jrheum.170146


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[PMID]:29453865
[Au] Autor:Lipner SR
[Ad] Endereço:Department of Dermatology, Weill Cornell Medicine, New York, New York.
[Ti] Título:Ulcerated Nodule of the Fingernail.
[So] Source:JAMA;319(7):713-714, 2018 Feb 20.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Melanoma/patologia
Doenças da Unha/patologia
Unhas/patologia
Neoplasias Cutâneas/patologia
Úlcera/patologia
[Mh] Termos MeSH secundário: Adulto
Biópsia
Seres Humanos
Imuno-Histoquímica
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180218
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2018.0179


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[PMID]:29394012
[Au] Autor:Ludwinski C; Clochard-Bossuet A; Chen T; Norwood K; Oresajo C
[Ti] Título:Use of optical profilometry and visual grading for measurement of longitudinal striations of the nail.
[So] Source:J Cosmet Sci;67(2):93-100, 2016 Mar-Apr.
[Is] ISSN:1525-7886
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Consumer perception of longitudinal striations of the nail is one of the drivers of nail cosmetic purchase and use. The following work investigates the use of objective instrumental methods for the characterization of longitudinal striations. Striations are quantified by Ra (the average maximum height of the profile), Rq (the root mean square average of the roughness profile), and Rz (the mean roughness depth), industrial roughness parameters, which are calculated using optical profilometry of the three-dimensional surface structure of the nail. A visual assessment is conducted by cosmetologists in vivo and on images captured in several lighting conditions. With this evaluation, the cosmetologists provide ratings of surface ridges on a 0­5 scale to complement and validate the instrumental method. Both the optical profilometry and the cosmetologist-graded methods are used to evaluate 33 nails of visually-varying levels of ridges from female volunteers. The evaluations from these methods yield well-correlated and repeatable results, and these preliminary findings suggest that this new instrumental method can be used to objectively measure longitudinal striations of the nail.
[Mh] Termos MeSH primário: Unhas/diagnóstico por imagem
Fotometria/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Cosméticos/administração & dosagem
Feminino
Seres Humanos
Meia-Idade
Unhas/anatomia & histologia
Fotometria/instrumentação
Reprodutibilidade dos Testes
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cosmetics)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE


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[PMID]:29091566
[Au] Autor:Gómez-Moyano E; Crespo-Erchiga V
[Ad] Endereço:Hospital Regional Universitario de Málaga, Malaga, Spain elisabeth.gomez.moyano@gmail.com.
[Ti] Título:HIV Infection Manifesting as Proximal White Onychomycosis.
[So] Source:N Engl J Med;377(18):e26, 2017 Nov 02.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Infecções Oportunistas Relacionadas com a AIDS/microbiologia
Dermatoses do Pé/etiologia
Infecções por HIV/complicações
Onicomicose/etiologia
Trichophyton/isolamento & purificação
[Mh] Termos MeSH secundário: Infecções por HIV/diagnóstico
Seres Humanos
Masculino
Meia-Idade
Unhas/microbiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171102
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMicm1703082


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[PMID]:29044488
[Au] Autor:Greig A; Gardiner MD; Sierakowski A; Zweifel CJ; Pinder RM; Furniss D; Cook JA; Beard D; Farrar N; Cooper CD; Jain A; NINJA Pilot Collaborative
[Ad] Endereço:Department of Plastic Surgery, Guy's and St Thomas' NHS Foundation Trust, London, UK.
[Ti] Título:Randomized feasibility trial of replacing or discarding the nail plate after nail-bed repair in children.
[So] Source:Br J Surg;104(12):1634-1639, 2017 Nov.
[Is] ISSN:1365-2168
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Nail-bed injuries are the most common hand injury in children. Surgical dogma is to replace the nail plate after repairing the nail bed. Recent evidence suggests this might increase infection rates and returns to clinic. The aim of this feasibility trial was to inform the design and conduct of a definitive trial comparing replacing or discarding the nail plate after nail-bed repair. METHODS: This study recruited participants from four hand units in the UK between April and July 2015. Participants were children under the age of 16 years with a nail-bed injury requiring surgery. They were randomized to either having the nail plate replaced or discarded after nail-bed repair. The follow-up method was also allocated randomly (postal versus clinic). Information was collected on complications at 2 weeks and 30 days, and on nail-plate appearance at 4 months using the Zook classification. Two possible approaches to follow-up were also piloted and compared. RESULTS: During the recruitment phase, there were 156 potentially eligible children. Sixty were randomized in just over 3 months using remote web-based allocation. By 2 weeks, there were two infections, both in children with replaced nail plates. The nail-replaced group also experienced more complications. There was no evidence of a difference in return rates between postal and clinic follow-up. CONCLUSION: Recruitment was rapid and nail-bed repair appeared to have low complication and infection rates in this pilot trial. The findings have led to revision of the definitive trial protocol, including the mode and timing of follow-up, and modification of the Zook classification.
[Mh] Termos MeSH primário: Unhas/lesões
Unhas/cirurgia
Procedimentos Cirúrgicos Reconstrutivos
[Mh] Termos MeSH secundário: Adolescente
Antibacterianos/uso terapêutico
Criança
Pré-Escolar
Estudos de Viabilidade
Feminino
Seres Humanos
Lactente
Masculino
Dor/etiologia
Projetos Piloto
Complicações Pós-Operatórias
Estudos Prospectivos
Procedimentos Cirúrgicos Reconstrutivos/efeitos adversos
Infecção da Ferida Cirúrgica/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171019
[St] Status:MEDLINE
[do] DOI:10.1002/bjs.10673


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[PMID]:28985222
[Au] Autor:Sureda A; Bibiloni MDM; Julibert A; Aparicio-Ugarriza R; Palacios-Le Blé G; Pons A; Gonzalez-Gross M; Tur JA
[Ad] Endereço:Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands, Palma de Mallorca, Spain.
[Ti] Título:Trace element contents in toenails are related to regular physical activity in older adults.
[So] Source:PLoS One;12(10):e0185318, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim was to assess the trace element contents in toenails of older adults and its association with regular physical activity. Cross-sectional multicentre study in Spain, collecting data from a random sample of 380 participants (54% female) aged 55-80 years (men) and 60-80 years (women) with no previously documented cardiovascular disease. Physical activity performed was measured using the Minnesota Leisure-time Physical Activity Questionnaire. The 25 most inactive and 25 most active individuals for each sex were selected for this study (final sample n = 100). Anthropometric measurements were performed and toenail samples collected for calcium (Ca), chromium (Cr), iron (Fe), cobalt (Co), nickel (Ni), zinc (Zn), selenium (Se) and mercury (Hg) analysis. Significant differences between sexes were reported in Ca concentrations, women having lower concentrations than men. No differences were reported in trace element contents between active and inactive men. Active women showed higher Ca, Cr, Fe, Co, and Zn and lower Hg contents than their inactive peers (all p<0.05). Inactive women showed lower Ca and Co levels (735.0 mg/kg and 4.5 µg/kg, respectively) than inactive men (1170.0 mg/kg and 7.9 µg/kg, respectively). Active women had lower Ca and higher levels of Cr (936.0 mg/kg and 1230.0 µg/kg, respectively) than active men (1070.0 mg/kg and 522.0 µg/kg, respectively). The present data added new information on the element contents in toenails of healthy Spanish older adults. The concentration of trace elements was similar in both sexes except for Ca which were lower in women. The trace element contents in women's toenails, but not in men, were markedly influenced by physical activity, with higher levels of Ca and Fe and lower Hg among active females.
[Mh] Termos MeSH primário: Exercício/fisiologia
Unhas/química
Oligoelementos/análise
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Cálcio/análise
Cromo/análise
Cobalto/análise
Estudos Transversais
Feminino
Seres Humanos
Ferro/análise
Masculino
Mercúrio/análise
Meia-Idade
Níquel/análise
Selênio/análise
Fatores Sexuais
Espanha
Zinco/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Trace Elements); 0R0008Q3JB (Chromium); 3G0H8C9362 (Cobalt); 7OV03QG267 (Nickel); E1UOL152H7 (Iron); FXS1BY2PGL (Mercury); H6241UJ22B (Selenium); J41CSQ7QDS (Zinc); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171022
[Lr] Data última revisão:
171022
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185318


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[PMID]:28980892
[Au] Autor:Jang J; Morris JS; Park K
[Ad] Endereço:1Department of Food and Nutrition,Yeungnam University,Gyeongsan,Gyeongbuk 38541,Republic of Korea.
[Ti] Título:Toenail selenium levels and prevalence of dyslipidaemia among Korean adults.
[So] Source:Br J Nutr;118(6):473-480, 2017 Sep.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Multiple studies have elucidated the antioxidant properties of Se, which are now well known among the nutrition and biomedical science communities. Recently, considerable interest has been focused on the possible association between Se exposure and risk of metabolic disease, such as lipid dysregulation; however, there is limited epidemiological data on this topic. The present study aimed to investigate associations between toenail Se levels and dyslipidaemia or individual lipid levels, and to examine the effect of dietary supplement use on these associations. We analysed baseline data from a cohort in the Yeungnam area, including 232 men and 269 women. Information on demographic, dietary and lifestyle characteristics was obtained through a self-reported questionnaire. Se levels in toenail specimens were measured using neutron activation analysis. Fasting blood lipid levels were measured during medical examinations. After adjusting for multiple confounding variables, we observed no association between toenail Se levels and dyslipidaemia or individual lipid profiles. However, the association was modified by dietary supplement use. Among the supplement users, higher toenail Se levels were associated with a higher prevalence of lipid dysregulation, whereas non-users exhibited a lower prevalence of lipid dysregulation. Associations between toenail Se levels, lipid levels and dyslipidaemia may be influenced by taking dietary supplements. Future large-scale, prospective cohort studies should be conducted to further evaluate the association between Se levels in the body and metabolic health effects in light of increasing rates of dietary supplement use.
[Mh] Termos MeSH primário: Grupo com Ancestrais do Continente Asiático
Dislipidemias/epidemiologia
Unhas/química
Selênio/análise
[Mh] Termos MeSH secundário: Adulto
Antioxidantes/análise
Índice de Massa Corporal
Estudos Transversais
Dieta
Suplementos Nutricionais
Dislipidemias/diagnóstico
Feminino
Seres Humanos
Estilo de Vida
Masculino
Meia-Idade
Estado Nutricional
Prevalência
República da Coreia
Selênio/administração & dosagem
Fatores Socioeconômicos
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); H6241UJ22B (Selenium)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171006
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517002343


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[PMID]:28957564
[Au] Autor:Boulon C; Blaise S; Lazareth I; Le Hello C; Pistorius MA; Imbert B; Mangin M; Sintes P; Senet P; Decamps-Le Chevoir J; Tribout L; Carpentier P; Constans J
[Ad] Endereço:Service de Médecine Vasculaire, Hôpital Saint-André, Bordeaux.
[Ti] Título:Reproducibility of the scleroderma pattern assessed by wide-field capillaroscopy in subjects suffering from Raynaud's phenomenon.
[So] Source:Rheumatology (Oxford);56(10):1780-1783, 2017 Oct 01.
[Is] ISSN:1462-0332
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objectives: The aim of this work was to study inter- and intra-observer agreement for the diagnosis of scleroderma pattern by wide-field capillaroscopy. Methods: Images were taken from 50 patients known to have SSc and 50 controls consulting for RP who did not have SSc. These images were rated simultaneously by 11 experienced vascular medicine physicians as scleroderma pattern or not. Two weeks later, 7 of the 11 observers again rated the same images. Results: Inter-observer agreement was almost perfect between the 11 observers (κ 0.86 ± 0.01), and the proportion of concordant observations was 79% (70-87). When each observer was compared with the reference, agreement was also almost perfect: κ coefficient 0.92 ± 0.03 and proportion of concordant observations 79% (70-87). Intra-observer agreement was also almost perfect: median κ coefficient 0.94 (0.78-0.96) and median proportion of concordant observations 97% (89-98). Conclusion: Excellent inter- and intra-observer agreement was obtained in experienced vascular physicians for the diagnosis of capillaroscopic landscape by wide-field nailfold capillary microscopy.
[Mh] Termos MeSH primário: Angioscopia Microscópica/estatística & dados numéricos
Doença de Raynaud/fisiopatologia
Escleroderma Sistêmico/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Feminino
Seres Humanos
Masculino
Angioscopia Microscópica/métodos
Unhas/irrigação sanguínea
Unhas/diagnóstico por imagem
Variações Dependentes do Observador
Doença de Raynaud/etiologia
Reprodutibilidade dos Testes
Escleroderma Sistêmico/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; VALIDATION STUDIES
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170929
[St] Status:MEDLINE
[do] DOI:10.1093/rheumatology/kex282


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[PMID]:28923798
[Au] Autor:DeKoven S; Holness DL
[Ad] Endereço:Doctor of Medicine Program (DeKoven), Schulich School of Medicine and Dentistry, London, Ont.; Division of Occupational Medicine (DeKoven, Holness), Department of Medicine, St. Michael's Hospital; Dalla Lana School of Public Health and Department of Medicine (Holness), University of Toronto; Centre for Urban Health Solutions (Holness), Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ont. sdekoven2018@meds.uwo.ca.
[Ti] Título:Contact dermatitis caused by methacrylates in nail products.
[So] Source:CMAJ;189(37):E1193, 2017 09 18.
[Is] ISSN:1488-2329
[Cp] País de publicação:Canada
[La] Idioma:eng
[Mh] Termos MeSH primário: Cosméticos/efeitos adversos
Dermatite Alérgica de Contato/etiologia
Metacrilatos/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Dermatite Alérgica de Contato/diagnóstico
Feminino
Seres Humanos
Unhas
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cosmetics); 0 (Methacrylates)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170920
[St] Status:MEDLINE
[do] DOI:10.1503/cmaj.170264



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