Base de dados : MEDLINE
Pesquisa : A18.024 [Categoria DeCS]
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[PMID]:28475363
[Au] Autor:Srivedavyasasri R; White MB; Kustova TS; Gemejiyeva NG; Cantrell CL; Ross SA
[Ad] Endereço:a National Center for Natural Product Research , University of Mississippi , University , MS , USA.
[Ti] Título:New tetranorlabdanoic acid from aerial parts of Salvia aethiopis.
[So] Source:Nat Prod Res;32(1):14-17, 2018 Jan.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Salvia aethiopis is a perennial plant native to Eurasia and known by the common names Mediterranean sage or African sage. This plant has been used in Iranian medicine as a carminative and tonic. The ethanolic extract of aerial part of S. aethiopis exhibited moderate to weak activity towards delta and kappa opioid receptors (46.3 and 45.3% displacement, respectively). Chromatographic purification of the ethanolic extract on silica gel column led to isolation of one new: 3α-hydroxy-8α-acetoxy-13,14,15,16-tetranorlabdan-12-oic acid (I) and three known compounds: sesquiterpene spathulenol (II), ß-sitosterol (III) and ß-sitosterol-3-O-glucoside (IV). The structures of all isolated compounds were elucidated by their NMR (1D and 2D) and MS spectral data. All the fractions and isolated compounds were tested for cannabinoid and opioid receptor binding assays.
[Mh] Termos MeSH primário: Componentes Aéreos da Planta/química
Receptores de Canabinoides/metabolismo
Salvia/química
[Mh] Termos MeSH secundário: Avaliação Pré-Clínica de Medicamentos/métodos
Irã (Geográfico)
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Plantas Medicinais/química
Receptores Opioides delta/metabolismo
Receptores Opioides kappa/metabolismo
Sesquiterpenos/química
Sesquiterpenos/metabolismo
Sesquiterpenos/farmacologia
Sitosteroides/química
Sitosteroides/metabolismo
Sitosteroides/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Receptors, Cannabinoid); 0 (Receptors, Opioid, delta); 0 (Receptors, Opioid, kappa); 0 (Sesquiterpenes); 0 (Sitosterols); 5LI01C78DD (gamma-sitosterol); 7XV9L96SJJ (spathulenol); U45VN859W3 (lyoniside)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170506
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1324961


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[PMID]:29247933
[Au] Autor:Ma J; Lei E; Lei M; Liu Y; Chen T
[Ad] Endereço:Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, PR China; Agro-Environmental Protection Institute, Ministry of Agriculture, Tianjin 300191, PR China; College of Natural Resources and Environment, South China Agricultural University, Guang
[Ti] Título:Remediation of Arsenic contaminated soil using malposed intercropping of Pteris vittata L. and maize.
[So] Source:Chemosphere;194:737-744, 2018 Mar.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Intercropping of arsenic (As) hyperaccumulator and cash crops during remediation of contaminated soil has been applied in farmland remediation project. However, little is known about the fate of As fractions in the soil profile and As uptake within the intercropping plants under field condition. In this study, As removal, uptake, and translocation were investigated within an intercropping system of Pteris vittata L. (P. vittata) and maize (Zea mays). Results indicated that the concentration of As associated with amorphous Fe (hydr)oxides in the 10-20 cm soil layer was significantly lower under malposed intercropping of P. vittata and maize, and As accumulation in P. vittata and biomass of P. vittata were simultaneously higher under malposed intercropping than under coordinate intercropping, leading to a 2.4 times higher rate of As removal. Although maize roots absorbed over 13.4 mg kg As and maize leaves and flowers accumulated over 21.5 mg kg As (translocation factor higher than 1), grains produced in all intercropping modes accumulated lower levels of As, satisfying the standard for human consumption. Our results suggested that malposed intercropping of a hyperaccumulator and a low-accumulation cash crop was an ideal planting pattern for As remediation in soil. Furthermore, timely harvest of P. vittata, agronomic strategies during remediation, and appropriate management of the above ground parts of P. vittata and high-As tissues of cash crops may further improve remediation efficiency.
[Mh] Termos MeSH primário: Arsênico/farmacocinética
Pteris
Poluentes do Solo/análise
Zea mays/metabolismo
[Mh] Termos MeSH secundário: Arsênico/análise
Arsênico/metabolismo
Biodegradação Ambiental
Biomassa
Seres Humanos
Componentes Aéreos da Planta/química
Raízes de Plantas/química
Solo/química
Poluentes do Solo/metabolismo
Poluentes do Solo/farmacocinética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil); 0 (Soil Pollutants); N712M78A8G (Arsenic)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE


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[PMID]:29254897
[Au] Autor:Yang HH; Oh KE; Jo YH; Ahn JH; Liu Q; Turk A; Jang JY; Hwang BY; Lee KY; Lee MK
[Ad] Endereço:College of Pharmacy, Chungbuk National University, Cheongju 28160, Republic of Korea.
[Ti] Título:Characterization of tyrosinase inhibitory constituents from the aerial parts of Humulus japonicus using LC-MS/MS coupled online assay.
[So] Source:Bioorg Med Chem;26(2):509-515, 2018 01 15.
[Is] ISSN:1464-3391
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In the screening of natural products for the development as cosmetic ingredients, the EtOAc-soluble fraction of Humulus japonicus showed tyrosinase inhibitory activity. HPLC-MS/MS coupled online tyrosinase assay of EtOAc-soluble fraction of H. japonicus characterized the twenty-eight constituents including two unknown ones and their tyrosinase inhibitory activity. Fractionation of H. japonicus using various chromatographic techniques yielded thirty-eight compounds. The chemical structures of isolated compounds were identified by spectroscopic analysis. As characterized by HPLC-MS/MS analysis, we isolated twenty-four predicted compounds and further identified two unknown ones, named humulusides A (1) and B (2). Additional ten compounds were also identified by purification. Tyrosinase inhibitory activity of isolated compounds were evaluated, which was closely correlated with the results from HPLC-MS/MS coupled online tyrosinase assay. Consistent with predicted data, two major compounds, trans-N-coumaroyltyramine (14) and cis-N-coumaroyltyramine (15) showed tyrosinase inhibition with IC values of 40.6 and 36.4 µM. Taken together, H. japonicus is suggested as whitening ingredient in cosmetic products. In addition, HPLC-MS/MS coupled tyrosinase assay is powerful tool for predicting active compounds with short time and limited amounts, although identification of new compounds and verification of predicted data are also needs to be demonstrated by further experiment.
[Mh] Termos MeSH primário: Inibidores Enzimáticos/farmacologia
Humulus/química
Monofenol Mono-Oxigenase/antagonistas & inibidores
Componentes Aéreos da Planta/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Relação Dose-Resposta a Droga
Inibidores Enzimáticos/química
Inibidores Enzimáticos/isolamento & purificação
Seres Humanos
Estrutura Molecular
Monofenol Mono-Oxigenase/metabolismo
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Relação Estrutura-Atividade
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Plant Extracts); EC 1.14.18.1 (Monophenol Monooxygenase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE


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[PMID]:28449181
[Au] Autor:Corradi E; Schmidt N; Räber N; De Mieri M; Hamburger M; Butterweck V; Potterat O
[Ad] Endereço:Division of Pharmaceutical Biology, University of Basel, Switzerland.
[Ti] Título:Metabolite Profile and Antiproliferative Effects in HaCaT Cells of a Salix reticulata Extract.
[So] Source:Planta Med;83(14-15):1149-1158, 2017 Oct.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Phenolic constituents of (Salicaceae) and antiproliferative activity of an extract and individual compounds were investigated in immortalized human non-tumorigenic keratinocytes (HaCaT). A MeOH extract from aerial parts afforded several flavonoids, including luteolin and apigenin glycosides ( - and ) and catechin ( ), two procyanidin fractions, and the phenolic glucosides picein ( ), triandrin ( ), and salicortin ( ). In an adenosine triphosphate assay, the MeOH extract reduced cell viability by approximately 60 % at a concentration of 100 µg/mL. Cell proliferation was assessed with a BrdU incorporation ELISA assay. The extract inhibited proliferation of HaCaT cells in a concentration-dependent manner, with approximately 50 % inhibition at 100 µg/mL. In time-lapse assays, the extract showed distinct inhibitory effects on cell migration at concentrations of 12.5, 25, and 50 µg/mL. The activity of selected constituents was also determined. Luteolin-7-O- -glucuronide ( ) significantly inhibited cell proliferation at concentrations of 10 and 50 µM. In contrast, luteolin-7-O- -glucopyranoside ( ) and a procyanidin fraction (P1) had only weak effects, while picein ( ) and salicortin ( ) did not affect cell proliferation. Luteolin-7-O- -glucuronide (10 µM) and, to a lesser extent, the procyanidin fraction (10 µg/mL) also inhibited cell migration.
[Mh] Termos MeSH primário: Glicosídeos/farmacologia
Fenóis/farmacologia
Extratos Vegetais/farmacologia
Salix/química
[Mh] Termos MeSH secundário: Proliferação Celular/efeitos dos fármacos
Flavonas/metabolismo
Glucuronídeos/metabolismo
Glicosídeos/isolamento & purificação
Seres Humanos
Queratinócitos/efeitos dos fármacos
Componentes Aéreos da Planta/química
Extratos Vegetais/isolamento & purificação
Proantocianidinas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavones); 0 (Glucuronides); 0 (Glycosides); 0 (Phenols); 0 (Plant Extracts); 0 (Proanthocyanidins); S2V45N7G3B (flavone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1055/s-0043-109098


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[PMID]:28458099
[Au] Autor:Seo UM; Nguyen DH; Zhao BT; Min BS; Woo MH
[Ad] Endereço:College of Pharmacy, Catholic University of Daegu, Gyeongsan 38430, Republic of Korea.
[Ti] Título:Flavanonol glucosides from the aerial parts of Agrimonia pilosa Ledeb. and their acetylcholinesterase inhibitory effects.
[So] Source:Carbohydr Res;445:75-79, 2017 Jun 05.
[Is] ISSN:1873-426X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Two new flavanonol glucoside isomers, (2R,3S)-dihydrokaempferol 3-O-ß-D-glucoside (1) and (2S,3R)-dihydrokaempferol 3-O-ß-D-glucoside (2), were isolated from the aerial parts of Agrimonia pilosa Ledeb., along with eight known flavanonol glucosides (3-10). Their structures were determined on the basis of spectroscopic analysis. In addition, these compounds were evaluated to determine their acetylcholinesterase inhibitory activities. The results indicated that these compounds have moderate inhibitory effects, with IC values ranging from 76.59 ± 1.16 to 97.53 ± 1.64 µM, except compounds 1 and 4 were inactive.
[Mh] Termos MeSH primário: Acetilcolinesterase/metabolismo
Agrimonia/química
Flavanonas/química
Glucosídeos/química
Glucosídeos/farmacologia
Componentes Aéreos da Planta/química
[Mh] Termos MeSH secundário: Inibidores da Colinesterase/química
Inibidores da Colinesterase/farmacologia
Concentração Inibidora 50
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cholinesterase Inhibitors); 0 (Flavanones); 0 (Glucosides); EC 3.1.1.7 (Acetylcholinesterase)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180125
[Lr] Data última revisão:
180125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


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[PMID]:29190454
[Au] Autor:Mathioudaki A; Berzesta A; Kypriotakis Z; Skaltsa H; Heilmann J
[Ad] Endereço:Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis, Zografou, 157 71, Athens, Greece; Universität Regensburg, Pharmaceutical Biology, Universitätsstr. 31, D-93053, Regensburg, Germany.
[Ti] Título:Phenolic metabolites from Hypericum kelleri Bald., an endemic species of Crete (Greece).
[So] Source:Phytochemistry;146:1-7, 2018 Feb.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Thirteen compounds were isolated from the aerial parts of Hypericum kelleri Bald., growing as an endemic on the island of Crete (Greece). These compounds comprise four previously unknown prenylated xanthones 1,2-dihydro-3,8-dihydroxy-6-methoxy-1,1,5-tri(3-methylbut-2-enyl)xanthen-2,9-dione (kellerine A), 1,2-dihydro-3,6,8-trihydroxy-1,1,5-tri(3-methylbut-2-enyl)xanthen-2,9-dione (kellerine B), 1,2-dihydro-3,8-dihydroxy-6-methoxy-1,1-bi(3-methylbut-2-enyl)xanthen-2,9-dione (6-methylpatulone), (R/S)-1,3,5-trihydroxy-2-(3-methyl-2-buten-1-yl)-4-[2-(3-methylbut-2-enyl)-3-methylbut-3-enyl]-6-methoxy-9H-xanthen-9-one ((2″R/S)-kellerine C) and the hitherto undescribed depsidone (R/S)-1,3,6-trihydroxy-5-methoxy-2-(3-methyl-2-buten-1-yl)-4-[2-(3-methylbut-2-enyl)-3-methylbut-3-enyl]-11Η-dibenzo[b,e] [1,4]dioxepin-9-one ((2″R/S)-creticine). As known compounds, brevipsidone D, 4-geranyl-2-(2'-isobutyryl)-phloroglucinol, 4-geranyl-2-(2'-methylbutyryl)-phloroglucinol, I3, II8-biapigenin, quercetin, avicularin, pseudohypericin and neochlorogenic acid have been isolated. The structures were elucidated on the basis of their 1D, 2D NMR, CD and MS data. The study confirms the typical occurrence of xanthones in Hypericum section Oligostema (Boiss.) Stef., and is also the first report on the simultaneous isolation of acylphloroglucinols in this section. Furthermore the first evidence of depsidones in the genus Hypericum L. is reported. Cytotoxicity was investigated in HeLa cells for prenylated xanthones and the depsidones. Both triprenylated 1,2-dihydroxanthones (kellerine A and B) showed significant in vitro cytotoxicity with IC values of 2.5 ± 0.1 (kellerine A) and 5.9 ± 0.9 (kellerine B) µM, whereas other compounds were less cytotoxic (IC > 20 µM).
[Mh] Termos MeSH primário: Hypericum/química
Fenóis/farmacologia
[Mh] Termos MeSH secundário: Sobrevivência Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Grécia
Células HeLa
Seres Humanos
Estrutura Molecular
Fenóis/química
Fenóis/isolamento & purificação
Componentes Aéreos da Planta/química
Relação Estrutura-Atividade
Células Tumorais Cultivadas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phenols)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE


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[PMID]:28746739
[Au] Autor:Tavallali V; Rahmati S; Rowshan V
[Ad] Endereço:Department of Agriculture, Payame Noor University (PNU), P.O. Box: 19395-3697, Tehran, Iran.
[Ti] Título:Characterization and Influence of Green Synthesis of Nano-Sized Zinc Complex with 5-Aminolevulinic Acid on Bioactive Compounds of Aniseed.
[So] Source:Chem Biodivers;14(11), 2017 Nov.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:A new water soluble zinc-aminolevulinic acid nano complex (n[Zn(ALA) ]), which was characterized by TEM, IR, and EDX spectra, has been prepared via sonochemical method under green conditions in water. In the current study, the effectiveness of foliar Zn amendment using synthetic Zn-ALA nano complex, as a new introduced Zn-fertilizer here, was evaluated. As the model plant, Pimpinella anisum, the most valuable spice and medicinal plant grown in warm regions, was used. By using zinc nano complex, further twenty compounds were obtained in the essential oil of anise plants. Application of 0.2% (w/v) Zn-ALA nano complex increased the levels of (E)-anethole, ß-bisabolene, germacrene D, methyl chavicol, and α-zingiberene in the essential oil. Nano Zn complex at the rate of 0.2% induced considerable high phenolic compounds and zinc content of shoots and seeds. Chlorogenic acid had the highest level between four detected phenolic compounds. The maximum antioxidant activity was monitored through the application of Zn nano complex. According to the results, nanoscale nutrients can be provided with further decreased doses for medicinal plants. Using Zn-ALA nano complex is a new and efficient method to improve the pharmaceutical and food properties of anise plants.
[Mh] Termos MeSH primário: Ácido Aminolevulínico/química
Nanopartículas Metálicas/química
Óleos Voláteis/análise
Pimpinella/química
Zinco/química
[Mh] Termos MeSH secundário: Frutas/química
Frutas/metabolismo
Química Verde
Microscopia Eletrônica de Transmissão
Óleos Voláteis/química
Tamanho da Partícula
Pimpinella/metabolismo
Componentes Aéreos da Planta/química
Componentes Aéreos da Planta/metabolismo
Brotos de Planta/química
Brotos de Planta/metabolismo
Espectrometria por Raios X
Espectroscopia de Infravermelho com Transformada de Fourier
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oils, Volatile); 88755TAZ87 (Aminolevulinic Acid); J41CSQ7QDS (Zinc)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201700197


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[PMID]:28869908
[Au] Autor:Zhang YY; Jiang HY; Liu M; Hu K; Wang WG; Du X; Li XN; Pu JX; Sun HD
[Ad] Endereço:State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China; University of Chinese Academy of Sciences, Beijing, 10039, People's Republic of China; Yunnan Key Laboratory of Natural Med
[Ti] Título:Bioactive ent-kaurane diterpenoids from Isodon rubescens.
[So] Source:Phytochemistry;143:199-207, 2017 Nov.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Seven previously undescribed 7,20-epoxy-ent-kaurane diterpenoids, isojiangrubesins A-G, along with seventeen known ones, were isolated from the aerial parts of Isodon rubescens. Their structures were characterized on the basis of spectroscopic methods and signal-crystal X-ray diffraction. All of these compounds were evaluated for their in vitro cytotoxicity against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480). Four isolates exhibited significant inhibitory ability against all cell lines, with IC values ranging from 0.5 to 6.5 µM; They also strongly inhibited NO production in LPS-stimulated RAW264.7 cells.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/farmacologia
Diterpenos Caurânicos/isolamento & purificação
Diterpenos Caurânicos/farmacologia
Medicamentos de Ervas Chinesas/isolamento & purificação
Medicamentos de Ervas Chinesas/farmacologia
Isodon/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Cristalografia por Raios X
Diterpenos Caurânicos/química
Ensaios de Seleção de Medicamentos Antitumorais
Medicamentos de Ervas Chinesas/química
Células HL-60
Seres Humanos
Lipopolissacarídeos/farmacologia
Macrófagos/efeitos dos fármacos
Estrutura Molecular
Óxido Nítrico/biossíntese
Componentes Aéreos da Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Diterpenes, Kaurane); 0 (Drugs, Chinese Herbal); 0 (Lipopolysaccharides); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170905
[St] Status:MEDLINE


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[PMID]:28843162
[Au] Autor:Snene A; Sirignano C; Rigano D; Formisano C; El Mokni R; Ercolano G; Dhaouadi H; Ianaro A; Hammami S; Taglialatela-Scafati O
[Ad] Endereço:Research Unit Applied Chemistry and Environment 13ES63, Monastir University, Faculty of Sciences of Monastir, 5000 Monastir, Tunisia.
[Ti] Título:Antiproliferative metabolites from the Northern African endemic plant Daucus virgatus (Apiaceae).
[So] Source:Phytochemistry;143:194-198, 2017 Nov.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Chemical analysis of the dichloromethane fraction obtained from aerial parts of the Northern African endemic plant Daucus virgatus led to the isolation of three previously undescribed sesquiterpenoids, namely the daucane vaginatin B, a eudesmane and the elemane elemavirgolide, along with five known metabolites. The structures of these compounds were determined by a detailed MS and NMR analysis and they were evaluated for antiproliferative activity against three human cell lines, A375 (melanoma), MCF-7 (breast adenocarcinoma), and HACAT (keratinocyte). The phytoalexin 6-methoxymellein revealed a previously unreported antiproliferative activity, while the eudesmane and the elemane derivatives exhibited a selective activity (SI = 11.1 and 3.3, respectively) against melanoma tumor cell lines.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/farmacologia
Apiaceae/química
Sesquiterpenos de Eudesmano/isolamento & purificação
Sesquiterpenos de Eudesmano/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Proliferação Celular/efeitos dos fármacos
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Isocumarinas/química
Isocumarinas/isolamento & purificação
Isocumarinas/farmacologia
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Componentes Aéreos da Planta/química
Sesquiterpenos
Sesquiterpenos de Eudesmano/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Isocoumarins); 0 (Sesquiterpenes); 0 (Sesquiterpenes, Eudesmane); 37297-20-4 (phytoalexins); 473-11-0 (eudesmane); 6803-02-7 (6-methoxy-8-hydroxy-3-methyl-3,4-dihydroisocoumarin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170827
[St] Status:MEDLINE


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[PMID]:28774308
[Au] Autor:Ahmed M; Fatima H; Qasim M; Gul B; Ihsan-Ul-Haq
[Ad] Endereço:Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
[Ti] Título:Polarity directed optimization of phytochemical and in vitro biological potential of an indigenous folklore: Quercus dilatata Lindl. ex Royle.
[So] Source:BMC Complement Altern Med;17(1):386, 2017 Aug 03.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Plants have served either as a natural templates for the development of new chemicals or a phytomedicine since antiquity. Therefore, the present study was aimed to appraise the polarity directed antioxidant, cytotoxic, protein kinase inhibitory, antileishmanial and glucose modulatory attributes of a Himalayan medicinal plant- Quercus dilatata. METHODS: Total phenolic and flavonoid contents were determined colorimetrically and various polyphenols were identified by RP-HPLC analysis. Brine shrimp lethality, SRB and MTT assays were employed to test cytotoxicity against Artemia salina and human cancer cell lines respectively. Antileishmanial activity was determined using standard MTT protocol. Glucose modulation was assessed by α-amylase inhibition assay while disc diffusion assay was used to establish protein kinase inhibitory and antifungal spectrum. RESULTS: Among 14 extracts of aerial parts, distilled water-acetone extract demonstrated maximum extract recovery (10.52% w/w), phenolic content (21.37 ± 0.21 µg GAE/mg dry weight (DW)), total antioxidant capacity (4.81 ± 0.98 µg AAE/mg DW) and reducing power potential (20.03 ± 2.4 µg/mg DW). On the other hand, Distilled water extract proficiently extracted flavonoid content (4.78 ± 0.51 µg QE/mg DW). RP-HPLC analysis revealed the presence of significant amounts of phenolic metabolites (0.049 to 15.336 µg/mg extract) including, pyrocatechol, gallic acid, catechin, chlorogenic acid, p-coumaric acid, ferulic acid and quercetin. Highest free radical scavenging capacity was found in Methanol-Ethyl acetate extract (IC 8.1 ± 0.5 µg/ml). In the brine shrimp toxicity assay, most of the tested extracts (57%) showed high cytotoxicity. Among these, Chloroform-Methanol extract had highest cytotoxicity against THP-1 cell line (IC 3.88 ± 0.53 µg/ml). About 50% of the extracts were found to be moderately antiproliferative against Hep G2 cell line. Methanol extract exhibited considerable protein kinase inhibitory activity against Streptomyces 85E strain (28 ± 0.35 mm bald phenotype at 100 µg/disc; MIC = 12.5 µg/ disc) while, Chloroform extract displayed maximum antidiabetic activity (α-amylase inhibition of 21.61 ± 1.53% at 200 µg/ml concentration). The highest antileishmanial potential was found in Ethyl acetate-Acetone extract (12.91 ± 0.02% at 100 µg/ml concentration), while, Q. dilatata extracts also showed a moderate antifungal activity. CONCLUSION: This study proposes that multiple-solvent system is a crucial variable to elucidate pharmacological potential of Q. dilatata and the results of the present findings prospects its potential as a resource for the discovery of novel anticancer, antidiabetic, antileishmanial and antioxidant agents.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Antioxidantes/farmacologia
Hipoglicemiantes/farmacologia
Extratos Vegetais/farmacologia
Inibidores de Proteínas Quinases/farmacologia
Quercus/química
Tripanossomicidas/farmacologia
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Antifúngicos/farmacologia
Antineoplásicos Fitogênicos/uso terapêutico
Antioxidantes/uso terapêutico
Flavonoides/isolamento & purificação
Flavonoides/farmacologia
Flavonoides/uso terapêutico
Células Hep G2
Medicina Herbária
Seres Humanos
Leishmania/efeitos dos fármacos
Medicina Tradicional
Neoplasias/tratamento farmacológico
Fenóis/isolamento & purificação
Fenóis/farmacologia
Fenóis/uso terapêutico
Fitoterapia
Componentes Aéreos da Planta
Extratos Vegetais/química
Extratos Vegetais/uso terapêutico
Solventes
Streptomyces/efeitos dos fármacos
alfa-Amilases/antagonistas & inibidores
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Antioxidants); 0 (Flavonoids); 0 (Hypoglycemic Agents); 0 (Phenols); 0 (Plant Extracts); 0 (Protein Kinase Inhibitors); 0 (Solvents); 0 (Trypanocidal Agents); EC 3.2.1.1 (alpha-Amylases)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170805
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1894-x



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