Base de dados : MEDLINE
Pesquisa : A18.024.937.750 [Categoria DeCS]
Referências encontradas : 3014 [refinar]
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  1 / 3014 MEDLINE  
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[PMID]:28554232
[Au] Autor:Guo T; Tan SB; Wang Y; Chang J
[Ad] Endereço:a School of Life Science and Engineering , Lanzhou University of Technology , Lanzhou , China.
[Ti] Título:Two new monoterpenoid glycosides from the fresh rhizome of Tongling White Ginger (Zingiber officinale).
[So] Source:Nat Prod Res;32(1):71-76, 2018 Jan.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two new monoterpenoid glycosides, trans-1,8-cineole-3,6-dihydroxy-3-O-ß-D-glucopyranoside (1), and 5,9-dihydroxy borneol 2-O-ß-D-glucopyranoside (2), together with four known monoterpenoid glycosides (3-6), were isolated from the water-soluble constituents of the fresh rhizome of Tongling White Ginger (Zingiber officinale). Their structures were decisively elucidated by spectroscopic analysis. In vitro tests for antimicrobial activity showed that compounds 1 and 3 possess significant activity against two Gram-positive organisms, Staphylococcus aureus and Staphylococcus epidermidis.
[Mh] Termos MeSH primário: Antibacterianos/química
Gengibre/química
Glicosídeos/química
Monoterpenos/química
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Glicosídeos/farmacologia
Espectroscopia de Ressonância Magnética
Testes de Sensibilidade Microbiana
Estrutura Molecular
Monoterpenos/farmacologia
Rizoma/química
Solubilidade
Espectrometria de Massas por Ionização por Electrospray
Staphylococcus aureus/efeitos dos fármacos
Staphylococcus epidermidis/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Glycosides); 0 (Monoterpenes)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170531
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1333994


  2 / 3014 MEDLINE  
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[PMID]:28480734
[Au] Autor:Kumar A; Chand G; Agnihotri VK
[Ad] Endereço:a Academy of Scientific and Innovative Research , CSIR-Institute of Himalayan Bioresource Technology , Palampur , India.
[Ti] Título:A new oxo-sterol derivative from the rhizomes of Costus speciosus.
[So] Source:Nat Prod Res;32(1):18-22, 2018 Jan.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Chemical investigation of the rhizomes of Costus speciosus led to the isolation of a new compound, 22-ketocholesteryl palmitate (1) along with four known compounds, 24-methylenecycloartanol (2), cycloartanol (3), stigmasterol (4) and linoleic acid (5). The structure of new compound was characterised by extensive 1D-, 2D-NMR and mass spectrometry (GC-MS and HR-ESI-MS) techniques.
[Mh] Termos MeSH primário: Costus/química
Cetosteroides/química
Rizoma/química
Esteróis/química
[Mh] Termos MeSH secundário: Cromatografia Gasosa-Espectrometria de Massas
Ácido Linoleico/química
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Espectrometria de Massas por Ionização por Electrospray/métodos
Estigmasterol/química
Triterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (24-methylenecycloartenol); 0 (Ketosteroids); 0 (Sterols); 0 (Triterpenes); 99WUK5D0Y8 (Stigmasterol); 9KJL21T0QJ (Linoleic Acid)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1324962


  3 / 3014 MEDLINE  
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[PMID]:28460115
[Au] Autor:Fan Z; Cai Z; Shan J; Yang J
[Ad] Endereço:State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, and Key Laboratory of Ministry of Education for Microbial and Plant Genetic Engineering, Guangxi University, Nanning 530004, China.
[Ti] Título:Letter to the Editor: Bud Position and Carbohydrate Play a More Significant Role than Light Condition in the Developmental Transition between Rhizome Buds and Aerial Shoot Buds of Oryza longistaminata.
[So] Source:Plant Cell Physiol;58(8):1281-1282, 2017 08 01.
[Is] ISSN:1471-9053
[Cp] País de publicação:Japan
[La] Idioma:eng
[Mh] Termos MeSH primário: Oryza
Rizoma
[Mh] Termos MeSH secundário: Carboidratos
Regulação da Expressão Gênica de Plantas
Meristema
Brotos de Planta
[Pt] Tipo de publicação:LETTER; RESEARCH SUPPORT, NON-U.S. GOV'T; COMMENT
[Nm] Nome de substância:
0 (Carbohydrates)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1093/pcp/pcx061


  4 / 3014 MEDLINE  
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[PMID]:29262679
[Au] Autor:Liu Q; Li W; Nagata K; Fu H; Okada S; Tanabe I; Kobori Y; Higai K; Norie W; Sasaki T; Asada Y; Zhao H; Bai H; Koike K
[Ad] Endereço:Faculty of Pharmaceutical Sciences, Toho University , Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan.
[Ti] Título:Isolation, Structural Elucidation, and Liquid Chromatography-Mass Spectrometry Analysis of Steroidal Glycosides from Polygonatum odoratum.
[So] Source:J Agric Food Chem;66(2):521-531, 2018 Jan 17.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The rhizomes of Polygonatum odoratum represent a traditional Chinese medicine and functional food. A phytochemical investigation resulted in the isolation of eight steroidal glycosides (1-8), including two new compounds, polygonatumosides F (1) and G (2). The structures were elucidated by spectroscopic data and chemical reactions. Compound 7 showed antiproliferation activity against human hepatocellular carcinoma cell line HepG2 (IC of 3.2 µM). The chemical profile and contents of steroidal glycosides of P. odoratum rhizomes collected at different dates and geographical locations were also investigated, indicating that the rational harvest of P. odoratum in spring and autumn is preferable to obtain higher levels of steroidal glycosides. Compounds 1 and 7 showed the highest contents in all P. odoratum samples and have potential to serve as chemotaxonomic and chemical markers for quality control of this important plant material. 14-Hydroxylation may be a key step for the biosynthesis of compounds 1-7.
[Mh] Termos MeSH primário: Glicosídeos/química
Glicosídeos/isolamento & purificação
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Polygonatum/química
Esteroides/química
Esteroides/isolamento & purificação
[Mh] Termos MeSH secundário: Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Cromatografia Líquida
Glicosídeos/farmacologia
Células Hep G2
Seres Humanos
Espectrometria de Massas
Estrutura Molecular
Extratos Vegetais/farmacologia
Rizoma/química
Esteroides/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycosides); 0 (Plant Extracts); 0 (Steroids)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04488


  5 / 3014 MEDLINE  
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[PMID]:29235376
[Au] Autor:Zhu LJ; Song Y; Shao P; Zhang X; Yao XS
[Ad] Endereço:a School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education , Shenyang Pharmaceutical University , Shenyang 110016 , China.
[Ti] Título:Matteucens I-J, phenolics from the rhizomes of Matteuccia orientalis.
[So] Source:J Asian Nat Prod Res;20(1):62-66, 2018 Jan.
[Is] ISSN:1477-2213
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two new phenolics, named matteucens I-J (1-2), were isolated from the 60% EtOH extract of the rhizomes of Matteuccia orientalis (HOOK.) TREV. Their structures were elucidated by means of extensive spectroscopic analysis (HRESIMS, NMR).
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/isolamento & purificação
Fenóis/isolamento & purificação
Polypodiaceae/química
Rizoma/química
[Mh] Termos MeSH secundário: Medicamentos de Ervas Chinesas/química
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Fenóis/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Phenols)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2017.1409735


  6 / 3014 MEDLINE  
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[PMID]:29190752
[Au] Autor:Zhang T; Huang L; Wang Y; Wang W; Zhao X; Zhang S; Zhang J; Hu F; Fu B; Li Z
[Ad] Endereço:Institute of Crop Sciences/National Key Facility for Crop Gene Resources and Genetic Improvement, Chinese Academy of Agricultural Sciences, Beijing, China.
[Ti] Título:Differential transcriptome profiling of chilling stress response between shoots and rhizomes of Oryza longistaminata using RNA sequencing.
[So] Source:PLoS One;12(11):e0188625, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Rice (Oryza sativa) is very sensitive to chilling stress at seedling and reproductive stages, whereas wild rice, O. longistaminata, tolerates non-freezing cold temperatures and has overwintering ability. Elucidating the molecular mechanisms of chilling tolerance (CT) in O. longistaminata should thus provide a basis for rice CT improvement through molecular breeding. In this study, high-throughput RNA sequencing was performed to profile global transcriptome alterations and crucial genes involved in response to long-term low temperature in O. longistaminata shoots and rhizomes subjected to 7 days of chilling stress. A total of 605 and 403 genes were respectively identified as up- and down-regulated in O. longistaminata under 7 days of chilling stress, with 354 and 371 differentially expressed genes (DEGs) found exclusively in shoots and rhizomes, respectively. GO enrichment and KEGG pathway analyses revealed that multiple transcriptional regulatory pathways were enriched in commonly induced genes in both tissues; in contrast, only the photosynthesis pathway was prevalent in genes uniquely induced in shoots, whereas several key metabolic pathways and the programmed cell death process were enriched in genes induced only in rhizomes. Further analysis of these tissue-specific DEGs showed that the CBF/DREB1 regulon and other transcription factors (TFs), including AP2/EREBPs, MYBs, and WRKYs, were synergistically involved in transcriptional regulation of chilling stress response in shoots. Different sets of TFs, such as OsERF922, OsNAC9, OsWRKY25, and WRKY74, and eight genes encoding antioxidant enzymes were exclusively activated in rhizomes under long-term low-temperature treatment. Furthermore, several cis-regulatory elements, including the ICE1-binding site, the GATA element for phytochrome regulation, and the W-box for WRKY binding, were highly abundant in both tissues, confirming the involvement of multiple regulatory genes and complex networks in the transcriptional regulation of CT in O. longistaminata. Finally, most chilling-induced genes with alternative splicing exclusive to shoots were associated with photosynthesis and regulation of gene expression, while those enriched in rhizomes were primarily related to stress signal transduction; this indicates that tissue-specific transcriptional and post-transcriptional regulation mechanisms synergistically contribute to O. longistaminata long-term CT. Our findings provide an overview of the complex regulatory networks of CT in O. longistaminata.
[Mh] Termos MeSH primário: Temperatura Baixa
Perfilação da Expressão Gênica
Oryza/fisiologia
Brotos de Planta/fisiologia
RNA de Plantas/genética
Rizoma/fisiologia
Estresse Fisiológico/genética
Transcriptoma
[Mh] Termos MeSH secundário: Processamento Alternativo
Oryza/genética
Análise de Sequência de RNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Plant)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188625


  7 / 3014 MEDLINE  
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[PMID]:27770616
[Au] Autor:Xiang L; Wang Y; Yi X; He X
[Ad] Endereço:School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
[Ti] Título:Antiproliferative and anti-inflammatory furostanol saponins from the rhizomes of Tupistra chinensis.
[So] Source:Steroids;116:28-37, 2016 12.
[Is] ISSN:1878-5867
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Phytochemical investigations of the rhizome of Tupistra chinensis led to the isolation of ten new furostanol saponins along with fourteen known spirostanols. Their chemical structures were elucidated on the basis of spectroscopic and chemical methods, including IR, NMR, MS, and GC analyses. The antiproliferative effects against FaDu and Detroit 562 cell lines and inhibitory activities on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in a macrophage cell line RAW 264.7 were assayed for all the isolated compounds. Compound 14 exhibited significant antiproliferative effects against FaDu and Detroit 562 cells with IC values of 1.1±0.1 and 1.2±0.1µM, respectively. Compounds 1, 2, 6, 13, 16, 19 and 24 exhibited inhibitory effects on NO production with IC values ranging from 15.7 to 46.2µM.
[Mh] Termos MeSH primário: Liliaceae/química
Rizoma/química
Saponinas/farmacologia
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios
Linhagem Celular
Seres Humanos
Lipopolissacarídeos/farmacologia
Macrófagos/efeitos dos fármacos
Macrófagos/metabolismo
Camundongos
Óxido Nítrico/metabolismo
Células RAW 264.7
Saponinas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Lipopolysaccharides); 0 (Saponins); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171218
[Lr] Data última revisão:
171218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161105
[St] Status:MEDLINE


  8 / 3014 MEDLINE  
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[PMID]:29078848
[Au] Autor:Budchart P; Khamwut A; Sinthuvanich C; Ratanapo S; Poovorawan Y; T-Thienprasert NP
[Ad] Endereço:Department of Biochemistry, Faculty of Science, Kasetsart University, Bangkok, Thailand.
[Ti] Título:Partially Purified Gloriosa superba Peptides Inhibit Colon Cancer Cell Viability by Inducing Apoptosis Through p53 Upregulation.
[So] Source:Am J Med Sci;354(4):423-429, 2017 Oct.
[Is] ISSN:1538-2990
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Colon cancer is a major health problem worldwide. Available treatments such as surgery, chemotherapy, radiation and anticancer drugs are limited due to stage of cancer, side effects and altered biodistribution. The use of peptides extracted from natural products has appeared as a potential therapy. Gloriosa superba is known to contain colchicine and other alkaloids with anticancer activity. However, these peptides contained within the extracts have not been studied. This study, therefore, focuses on an investigation of anti-colon cancer activity from a partially purified protein hydrolysate of G superba rhizome. METHODS: Dried G superba rhizome was extracted using 0.5% sodium dodecyl sulfate and digested with pepsin. The protein hydrolysates with molecular weight lesser than 3kDa were collected and subjected for cell viability assay. Then, the partial purification of the protein hydrolysate was performed using reverse-phase high-performance liquid chromatography. Fractions containing anticancer peptides were investigated, and their effects on apoptosis and protein expression using apoptosis test and Western blot, respectively. RESULTS: Partially purified peptides of G superba rhizome demonstrated anticolon activity in SW620 cells by inducing apoptosis through upregulation of p53 and downregulation of nuclear factor kappa B (NF-κB). CONCLUSIONS: Consequently, G superba peptides showed high potential for further purification and development of anticolon therapeutics.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Colchicaceae/química
Neoplasias do Colo/tratamento farmacológico
Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos
Peptídeos/farmacologia
Proteínas de Plantas/farmacologia
Rizoma/química
Proteína Supressora de Tumor p53/biossíntese
Regulação para Cima/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Fitogênicos/química
Apoptose/efeitos dos fármacos
Linhagem Celular Tumoral
Cercopithecus aethiops
Neoplasias do Colo/metabolismo
Neoplasias do Colo/patologia
Seres Humanos
Peptídeos/química
Proteínas de Plantas/química
Células Vero
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Peptides); 0 (Plant Proteins); 0 (TP53 protein, human); 0 (Tumor Suppressor Protein p53)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171029
[St] Status:MEDLINE


  9 / 3014 MEDLINE  
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[PMID]:28916257
[Au] Autor:Chen X; Zuo A; Deng Z; Huang X; Zhang X; Geng C; Li T; Chen J
[Ad] Endereço:State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
[Ti] Título:New phenolic glycosides from Curculigo orchioides and their xanthine oxidase inhibitory activities.
[So] Source:Fitoterapia;122:144-149, 2017 Oct.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Seven new phenolic glycosides including two heterocyclic phenolic derivatives orcinosides I-J (1-2) and five chlorophenolic glycosides curculigines J-N (3-7), together with nineteen known compounds were isolated from the rhizome of Curculigo orchioides. Based on extensive spectroscopic analyses (UV, IR, HRESIMS, 1D and 2D NMR), the structures of the new compounds were identified. Orcinoside I (1) and J (2) displayed xanthine oxidase inhibitory activities with IC values 0.25 and 0.62mM respectively.
[Mh] Termos MeSH primário: Curculigo/química
Inibidores Enzimáticos/química
Glicosídeos/química
Fenóis/química
Xantina Oxidase/antagonistas & inibidores
[Mh] Termos MeSH secundário: Inibidores Enzimáticos/isolamento & purificação
Glicosídeos/isolamento & purificação
Estrutura Molecular
Fenóis/isolamento & purificação
Rizoma/química
Uricosúricos/química
Uricosúricos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Glycosides); 0 (Phenols); 0 (Uricosuric Agents); EC 1.17.3.2 (Xanthine Oxidase)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170917
[St] Status:MEDLINE


  10 / 3014 MEDLINE  
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[PMID]:28910661
[Au] Autor:Wang LL; Zhao DS; Shi W; Li ZQ; Wu ZT; Li P; Li HJ
[Ad] Endereço:State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
[Ti] Título:Describing the holistic toxicokinetics of hepatotoxic Chinese herbal medicines by a novel integrated strategy: Dioscorea bulbifera rhizome as a case study.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1064:40-48, 2017 Oct 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:It is vital to monitor the holistic toxicokinetics of toxic Chinese herbal medicines (CHMs) for safety. Although an integrated strategy based on the area under the curve (AUC) has been proposed to characterize the pharmacokinetic/toxicokinetic properties of CHMs, improvement is still needed. This study attempted to use 50% inhibitory concentration (IC ) as weighting coefficient to investigate holistic toxicokinetics of the major diosbulbins i.e. diosbulbin A (DA), diosbulbin B (DB), and diosbulbin C (DC) after oral administration of Dioscorea bulbifera rhizome (DBR) extract. Firstly, the cytotoxicities of the three diosbulbins on human hepatic L02 cells were evaluated and the IC values were calculated. Then, integrated toxicokinetics of multiple diosbulbins based on AUC and IC were determined. Finally, correlations between integrated plasma concentrations and hepatic injury biomarkers including alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and total bile acid (TBA) were analyzed. As a result, integrated plasma concentrations were correlated well with TBA and the correlation between TBA and IC -weighting integrated plasma concentrations was better than that of AUC-weighting integrated plasma concentrations. In conclusion, the newly developed IC -weighting method is expected to generate more reasonable integrated toxicokinetic parameters, which will help to guide the safe usage of DBR in clinical settings.
[Mh] Termos MeSH primário: Dioscorea/química
Medicamentos de Ervas Chinesas
Compostos Heterocíclicos de 4 ou mais Anéis/sangue
Toxicocinética
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Cromatografia Líquida
Medicamentos de Ervas Chinesas/administração & dosagem
Medicamentos de Ervas Chinesas/farmacocinética
Medicamentos de Ervas Chinesas/toxicidade
Compostos Heterocíclicos de 4 ou mais Anéis/farmacocinética
Compostos Heterocíclicos de 4 ou mais Anéis/toxicidade
Seres Humanos
Concentração Inibidora 50
Modelos Lineares
Fígado/efeitos dos fármacos
Fígado/patologia
Masculino
Espectrometria de Massas
Ratos
Ratos Sprague-Dawley
Reprodutibilidade dos Testes
Rizoma/química
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Heterocyclic Compounds, 4 or More Rings); 20086-06-0 (diosbulbin B)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170915
[St] Status:MEDLINE



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