Base de dados : MEDLINE
Pesquisa : A19.374 [Categoria DeCS]
Referências encontradas : 1137 [refinar]
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  1 / 1137 MEDLINE  
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[PMID]:28597472
[Au] Autor:Tietel Z; Masaphy S
[Ad] Endereço:Tel Hai Academic College, Upper Galilee, Israel.
[Ti] Título:Aroma-volatile profile of black morel (Morchella importuna) grown in Israel.
[So] Source:J Sci Food Agric;98(1):346-353, 2018 Jan.
[Is] ISSN:1097-0010
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: A headspace solid-phase microextraction method with gas chromatography-mass spectrometry was used to profile the aroma volatiles of mature fruiting bodies of Morchella importuna grown in Israel. RESULTS: We tentatively identified 40 aroma compounds and seven unknown volatiles. The M. importuna aroma profile consisted of 14 aldehydes, six alcohols, 10 methyl esters, four heterocyclic/sulfur compounds, 10 carbohydrates and three other compounds (i.e. one acid, one ketone and one butyl ester). The most abundant volatiles were carbohydrates, with a total relative peak area of 29.3%, followed by alcohols (27.7%), aldehydes (21.6%), methyl esters (10.8%), heterocyclic/sulfur compounds (3.1%) and other compounds (5.8%). The 8-carbon (C8) compounds imparting typical mushroom-like aroma were very abundant in M. importuna, accounting for 27.9% of the total peak area and including, amongst others, 1-octen-3-ol (80% of total C8), octanal and 2-octenal (Z- and E-). CONCLUSION: The aroma volatile profile of morels has much in common with that of other mushrooms, with a few unique characteristics. To our knowledge, this is the first detailed report of the aroma profile of M. importuna. © 2017 Society of Chemical Industry.
[Mh] Termos MeSH primário: Ascomicetos/química
Compostos Orgânicos Voláteis/química
[Mh] Termos MeSH secundário: Ascomicetos/crescimento & desenvolvimento
Ascomicetos/metabolismo
Carpóforos/química
Carpóforos/crescimento & desenvolvimento
Carpóforos/metabolismo
Cromatografia Gasosa-Espectrometria de Massas
Israel
Odorantes/análise
Compostos Orgânicos Voláteis/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Volatile Organic Compounds)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171228
[Lr] Data última revisão:
171228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170610
[St] Status:MEDLINE
[do] DOI:10.1002/jsfa.8477


  2 / 1137 MEDLINE  
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[PMID]:27776228
[Au] Autor:Proskura N; Podlasinska J; Skopicz-Radkiewicz L
[Ad] Endereço:Department of Ecology, Environmental Protection and Management, West Pomeranian University of Technology, Szczecin, Slowackiego 17 St., 71-434, Szczecin, Poland. Electronic address: natalia.mazurkiewicz@zut.edu.pl.
[Ti] Título:Chemical composition and bioaccumulation ability of Boletus badius (Fr.) Fr. collected in western Poland.
[So] Source:Chemosphere;168:106-111, 2017 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of the study was to determine content of 17 elements (Co, Cd, Cu, Cr, Ni, Pb, Zn, Mn, Fe, Mg, Na, Ca, K, N, C, S and P) and their bioaccumulation factors (BCF) in bay bolete (Boletus badius (Fr.) Fr.) fruiting bodies (caps and stalks) and underneath soil samples collected from forest sites in lubuskie voivodeship in Poland. Forty-eight samples of Boletus badius (Fr.) Fr. fruiting bodies and the same number of underneath soil substrate samples were collected in forest sites of Sulecin Forest District in western Poland. Copper and zinc were absorbed most strongly from soil substrate, which is performed by bioaccumulation factors (BCF = 16.57 and 11.60, respectively), wherein Pb, Co, Cr, Fe and Mn were excluded from bioaccumulation (BCF < 1.0). The mean content of Cd in caps and stalks was 1.44 ± 0.88 and 2.01 ± 1.26 mg kg dry weight, respectively and in contrary to Pb (≈3.00 ± 2.66 and 2.01 ± 1.26 mg kg d. w.) this metal is strongly accumulated from subsoil (BCF = 11.12 and BCF = 10.83). The fruiting bodies of Boletus badius were distinguished by elevated content of Cr, Zn, Pb and Cd. Few statistically significant metal-to-metal correlations were observed. The correlation between forest habitat types and metals concentrations was also analysed. An attempt of estimation of Pb and Cd safe dose for human consumption was made. IN CONCLUSION: mushrooms can be a good source of some micro- and macroelements, but they also contain a great amount of toxic heavy metals.
[Mh] Termos MeSH primário: Agaricales/química
Carpóforos/química
Metais Pesados/análise
Poluentes do Solo/análise
Solo/química
[Mh] Termos MeSH secundário: Agaricales/crescimento & desenvolvimento
Carpóforos/crescimento & desenvolvimento
Seres Humanos
Polônia
Espectrofotometria Atômica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Metals, Heavy); 0 (Soil); 0 (Soil Pollutants)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171212
[Lr] Data última revisão:
171212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  3 / 1137 MEDLINE  
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[PMID]:29066302
[Au] Autor:Wang Y; Zeng X; Liu W
[Ad] Endereço:The Key Laboratory of Molecular Epigenetics of the Ministry of Education, Institute of Genetics and Cytology, School of Life Sciences, Northeast Normal University, Changchun, Jilin 130024, China.
[Ti] Título:De novo transcriptomic analysis during Lentinula edodes fruiting body growth.
[So] Source:Gene;641:326-334, 2018 Jan 30.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The fruiting body of Lentinula edodes is a popular edible mushroom, and extracts from the mycelium and the fruiting body of this species have diverse therapeutic potential. To gain insights into the molecular mechanisms underlying the fruiting body growth of L. edodes from the early bud stage (EBS), through the intermediate developing stage (IDS), to the fully developed stage (FDS), we performed de novo transcriptomic analysis using high-throughput Illumina RNA-sequencing. First, we generated three cDNA libraries representative of the three respective stages. We then obtained 38,933,148, 44,594,472, and 37,905,646 high-quality reads from the respective libraries and assembled the reads into 25,104 transcriptional contigs, containing 15,199 unigenes. We found that only 9331 of the unigenes had been annotated in the NCBI non-redundant protein database, and we functionally annotated 4758 of them through Gene Ontology (GO) analysis and 2921 of them through Clusters of Orthologous Groups of proteins (COGs) analysis. We also assigned 3995 unigenes to metabolic pathways by using the Kyoto Encyclopedia of Genes and Genomes (KEGG). We further identified 399 differentially expressed genes (DEGs) between EBS and IDS, 1428 between IDS and FDS, and 1830 between EBS and FDS, uncovering 769 DEGs in multiple metabolic and signaling pathways. Interestingly, there were a limited number of DEGs whose expression was dramatically associated with FDS. Finally, genes, whose expression was either highly up-regulated in FDS or remained at a high level during fruiting body growth, were annotated specifically in the pathways of purine metabolism, unsaturated fatty acid metabolism and meiosis, suggesting that these key molecular events were actively occurring in the fruiting body. Our work is the first high-throughput transcriptome study on the growth of L. edodes fruiting bodies, and the results uncovered candidate genes for future gene identification and utilization of this commercially and medically important mushroom.
[Mh] Termos MeSH primário: Agaricales/genética
Carpóforos/genética
Cogumelos Shiitake/genética
Transcriptoma/genética
[Mh] Termos MeSH secundário: Agaricales/metabolismo
Ácidos Graxos Insaturados/metabolismo
Carpóforos/metabolismo
Perfilação da Expressão Gênica/métodos
Ontologia Genética
Meiose/genética
Redes e Vias Metabólicas/genética
Purinas/metabolismo
Análise de Sequência de RNA/métodos
Cogumelos Shiitake/metabolismo
Transdução de Sinais/genética
Regulação para Cima/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids, Unsaturated); 0 (Purines); W60KTZ3IZY (purine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE


  4 / 1137 MEDLINE  
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[PMID]:28946308
[Au] Autor:Yan J; Han Z; Qu Y; Yao C; Shen D; Tai G; Cheng H; Zhou Y
[Ad] Endereço:Jilin Province Key Laboratory on Chemistry and Biology of Changbai Mountain Natural Drugs, School of Life Sciences, Northeast Normal University, Changchun 130024, PR China.
[Ti] Título:Structure elucidation and immunomodulatory activity of a ß-glucan derived from the fruiting bodies of Amillariella mellea.
[So] Source:Food Chem;240:534-543, 2018 Feb 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A novel polysaccharide AAMP-A70 (5.6kDa) has been purified from the fruiting bodies of Amillariella mellea. Compositional analysis and 1H and 13C NMR spectra indicate that AAMP-A70 is a branched ß-glucan with a main chain that consists of ß-d-(1→6) linked Glcρ residues substituted at O-3 by ß-Glcρ or α-d-(1→6)-linked Galρ side chains. AAMP-A70 increases macrophage phagocytosis and secretion of NO, ROS, TNF-α, IL-6 and IL-1ß. Mechanistically, AAMP-A70 promotes degradation of IκB-α and nuclear translocation of the NF-κB p65 subunit, and enhances phosphorylation of MAPKs. In particular, the function blocking antibody to TLR2 substantially suppresses TNF-α and IL-6 production. Our data demonstrate that AAMP-A70 activates macrophages via NF-κB/MAPK signaling pathways and the TLR2 receptor. Overall, AAMP-A70 may serve as a good food supplement to enhance immunity.
[Mh] Termos MeSH primário: Agaricales
[Mh] Termos MeSH secundário: Carpóforos
Glucanos
NF-kappa B
Transdução de Sinais
beta-Glucanas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucans); 0 (NF-kappa B); 0 (beta-Glucans)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170927
[St] Status:MEDLINE


  5 / 1137 MEDLINE  
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[PMID]:28859931
[Au] Autor:Chen L; Li ZH; Yao JN; Peng YL; Huang R; Feng T; Liu JK
[Ad] Endereço:School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
[Ti] Título:Isoindolinone-containing meroterpenoids with α-glucosidase inhibitory activity from mushroom Hericium caput-medusae.
[So] Source:Fitoterapia;122:107-114, 2017 Oct.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Hericium caput-medusae is an edible and medicinal mushroom closely relative to H. erinaceus. According to our detailed chemical investigation, two novel isoindolinone-containing meroterpene dimers, caputmedusins A (1) and B (2), as well as nine analogues, caputmedusins C-K (3-11), were isolated from the fermentation broth of H. caput-medusae. Their structures were elucidated by analyses of 1D and 2D NMR spectroscopic methods. The absolute configurations of 1-4 were speculated based on the specific optical rotation and biogenetic consideration. The absolute configurations of 10 and 11 were rationalized by the calculation of H NMR chemical shifts. Caputmedusins A-C (1-3) showed moderate inhibitory activity against α-glucosidase with the IC values of 39.2, 36.2 and 40.8µM, respectively.
[Mh] Termos MeSH primário: Agaricales/química
Basidiomycota/química
Inibidores de Glicosídeo Hidrolases/química
Indóis/química
Terpenos/química
[Mh] Termos MeSH secundário: Carpóforos/química
Indóis/isolamento & purificação
Estrutura Molecular
Terpenos/isolamento & purificação
alfa-Glucosidases/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycoside Hydrolase Inhibitors); 0 (Indoles); 0 (Terpenes); EC 3.2.1.20 (alpha-Glucosidases)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170902
[St] Status:MEDLINE


  6 / 1137 MEDLINE  
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[PMID]:28800422
[Au] Autor:Tohtahon Z; Xue J; Han J; Liu Y; Hua H; Yuan T
[Ad] Endereço:The Key Laboratory of Plant Resources and Chemistry of Arid Zone, and State Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China; University of Chinese Academy of Sciences
[Ti] Título:Cytotoxic lanostane triterpenoids from the fruiting bodies of Piptoporus betulinus.
[So] Source:Phytochemistry;143:98-103, 2017 Nov.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Chemical investigation of a bioactive methanolic extract of the fruiting bodies of Piptoporus betulinus led to the isolation of five previously undescribed lanostane triterpenoids named piptolinic acids A-E, as well as five known lanostane triterpenoids. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopic and HRESIMS analysis. Piptolinic acid A with an unusual moiety (3-hydroxy-4-methoxycarbonyl-3-methylbutyryloxy) at C-3 exhibited comparable cytotoxic activity against human promyelocytic leukemia cell line HL-60 (IC = 1.77 µM) and human acute monocytic leukemia cell line THP-1 (IC = 8.21 µM) to those of positive control, fluorouracil (IC = 6.38 and 4.41 µM, respectively).
[Mh] Termos MeSH primário: Antineoplásicos/isolamento & purificação
Antineoplásicos/farmacologia
Ganoderma/química
Triterpenos/isolamento & purificação
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos/química
Coriolaceae/química
Ensaios de Seleção de Medicamentos Antitumorais
Carpóforos/química
Células HL-60
Seres Humanos
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Triterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Triterpenes)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170812
[St] Status:MEDLINE


  7 / 1137 MEDLINE  
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[PMID]:28800421
[Au] Autor:Huang SZ; Ma QY; Kong FD; Guo ZK; Cai CH; Hu LL; Zhou LM; Wang Q; Dai HF; Mei WL; Zhao YX
[Ad] Endereço:Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou, 571101, People's Republic of China.
[Ti] Título:Lanostane-type triterpenoids from the fruiting body of Ganoderma calidophilum.
[So] Source:Phytochemistry;143:104-110, 2017 Nov.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:To search for active anti-cancer constituents in the fruiting body of Ganoderma calidophilum, we have successfully isolated four previously undescribed spiro-lactone lanostane triterpenoids (spiroganocalitones A-D), two previously undescribed lanostanoids (ganodecalones A and B) together with twenty-three known ones. The structures of the six previously undescribed compounds were elucidated based on 1D, 2D-NMR, and HRMS analyses. Ganoderone A showed moderate cytotoxic activity against K562, BEL7402, and SGC790 cell lines with IC values of 7.62, 6.28, and 3.55 µM, respectively.
[Mh] Termos MeSH primário: Carpóforos/química
Ganoderma/química
Lanosterol/análogos & derivados
Triterpenos/isolamento & purificação
[Mh] Termos MeSH secundário: Seres Humanos
Concentração Inibidora 50
Lanosterol/química
Lanosterol/isolamento & purificação
Lanosterol/farmacologia
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Triterpenos/química
Triterpenos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Triterpenes); 0 (lanostanoid); 1J05Z83K3M (Lanosterol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170812
[St] Status:MEDLINE


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[PMID]:28726108
[Au] Autor:Purtov KV; Petushkov VN; Rodionova NS; Gitelson JI
[Ad] Endereço:Institute of Biophysics, Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, 660036, Russia. purtovk@mail.ru.
[Ti] Título:Why does the bioluminescent fungus Armillaria mellea have luminous mycelium but nonluminous fruiting body?
[So] Source:Dokl Biochem Biophys;474(1):217-219, 2017 May.
[Is] ISSN:1608-3091
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:By determining the components involved in the bioluminescence process in luminous and nonluminous organs of the honey fungus Armillaria mellea, we have established causes of partial luminescence of this fungus. The complete set of enzymes and substrates required for bioluminescence is formed only in the mycelium and only under the conditions of free oxygen access. Since the synthesis of luciferin precursor (hispidin) and 3-hydroxyhispidin hydroxylase in the fruiting bodies is blocked, the formation of luciferin-the key component of fungal bioluminescent system-was not observed. That is why the fruiting body of Armillaria mellea is nonluminous despite the presence of luciferase, the enzyme that catalyzes the oxidation of luciferin with a photon emission.
[Mh] Termos MeSH primário: Armillaria/metabolismo
Carpóforos/metabolismo
Luminescência
Micélio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.1134/S1607672917030176


  9 / 1137 MEDLINE  
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[PMID]:28704372
[Au] Autor:Trail F; Wang Z; Stefanko K; Cubba C; Townsend JP
[Ad] Endereço:Department of Plant Biology, Michigan State University, East Lansing, MI, United States of America.
[Ti] Título:The ancestral levels of transcription and the evolution of sexual phenotypes in filamentous fungi.
[So] Source:PLoS Genet;13(7):e1006867, 2017 Jul.
[Is] ISSN:1553-7404
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Changes in gene expression have been hypothesized to play an important role in the evolution of divergent morphologies. To test this hypothesis in a model system, we examined differences in fruiting body morphology of five filamentous fungi in the Sordariomycetes, culturing them in a common garden environment and profiling genome-wide gene expression at five developmental stages. We reconstructed ancestral gene expression phenotypes, identifying genes with the largest evolved increases in gene expression across development. Conducting knockouts and performing phenotypic analysis in two divergent species typically demonstrated altered fruiting body development in the species that had evolved increased expression. Our evolutionary approach to finding relevant genes proved far more efficient than other gene deletion studies targeting whole genomes or gene families. Combining gene expression measurements with knockout phenotypes facilitated the refinement of Bayesian networks of the genes underlying fruiting body development, regulation of which is one of the least understood processes of multicellular development.
[Mh] Termos MeSH primário: Evolução Biológica
Genoma Fúngico/genética
Diferenciação Sexual/genética
Transcriptoma/genética
[Mh] Termos MeSH secundário: Teorema de Bayes
Carpóforos/genética
Fungos/genética
Regulação Fúngica da Expressão Gênica/genética
Técnicas de Inativação de Genes
Neurospora crassa/genética
Fenótipo
Filogenia
Sordariales/genética
Sordariales/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pgen.1006867


  10 / 1137 MEDLINE  
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[PMID]:28689410
[Au] Autor:Bang S; Chae HS; Lee C; Choi HG; Ryu J; Li W; Lee H; Jeong GS; Chin YW; Shim SH
[Ad] Endereço:College of Pharmacy, Duksung Women's University , Samyang-ro, Dobong-gu, Seoul 01369, Republic of Korea.
[Ti] Título:New Aromatic Compounds from the Fruiting Body of Sparassis crispa (Wulf.) and Their Inhibitory Activities on Proprotein Convertase Subtilisin/Kexin Type 9 mRNA Expression.
[So] Source:J Agric Food Chem;65(30):6152-6157, 2017 Aug 02.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Successive chromatography of EtOAc-soluble extracts of the fruiting body of Sparassis crispa (Wulf.) resulted in isolation of four new aromatic compounds, sparoside A (1) and sparalides A-C (3-5), two new naturally occurring compounds, 2 and 6, and eight known compounds, 7-14. The chemical structures were determined by interpretation of nuclear magnetic resonance and mass spectrometry spectroscopic data. Extract, solvent-soluble fractions of the extract, and all of the pure compounds isolated from the fractions were subjected to the mRNA expression assay for proprotein convertase subtilisin/kexin type 9 (PCSK9). Among them, sparoside A (1), hanabiratakelide A (8), adenosine (11), and 5α,6α-epoxy-(22E,24R)-ergosta-8(14),22-diene-3ß,7ß-diol (14) exhibited potent inhibitory activities on PCSK9 mRNA expression, with IC values of 20.07, 7.18, 18.46, and 8.23 µM, respectively (berberine, positive control, IC = 8.04 µM), suggesting that compounds 1, 8, 11, and 14 are suitable for use in supplements to the statins for hyperlipidemia treatments.
[Mh] Termos MeSH primário: Inibidores Enzimáticos/química
Carpóforos/química
Extratos Vegetais/química
Polyporales/química
Pró-Proteína Convertase 9/antagonistas & inibidores
[Mh] Termos MeSH secundário: Inibidores Enzimáticos/isolamento & purificação
Seres Humanos
Cinética
Estrutura Molecular
Extratos Vegetais/isolamento & purificação
Polyporales/crescimento & desenvolvimento
Pró-Proteína Convertase 9/genética
Pró-Proteína Convertase 9/metabolismo
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Plant Extracts); 0 (RNA, Messenger); EC 3.4.21.- (PCSK9 protein, human); EC 3.4.21.- (Proprotein Convertase 9)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170811
[Lr] Data última revisão:
170811
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170711
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b02657



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