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[PMID]:28640824
[Au] Autor:Akerele D; Ljolje D; Talundzic E; Udhayakumar V; Lucchi NW
[Ad] Endereço:Division of Pediatric Infectious Diseases, Emory Medical Center, Atlanta, Georgia, United States of America.
[Ti] Título:Molecular diagnosis of Plasmodium ovale by photo-induced electron transfer fluorogenic primers: PET-PCR.
[So] Source:PLoS One;12(6):e0179178, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Accurate diagnosis of malaria infections continues to be challenging and elusive, especially in the detection of submicroscopic infections. Developing new malaria diagnostic tools that are sensitive enough to detect low-level infections, user friendly, cost effective and capable of performing large scale diagnosis, remains critical. We have designed novel self-quenching photo-induced electron transfer (PET) fluorogenic primers for the detection of P. ovale by real-time PCR. In our study, a total of 173 clinical samples, consisting of different malaria species, were utilized to test this novel PET-PCR primer. The sensitivity and specificity were calculated using nested-PCR as the reference test. The novel primer set demonstrated a sensitivity of 97.5% and a specificity of 99.2% (95% CI 85.2-99.8% and 95.2-99.9% respectively). Furthermore, the limit of detection for P. ovale was found to be 1 parasite/µl. The PET-PCR assay is a new molecular diagnostic tool with comparable performance to other commonly used PCR methods. It is relatively easy to perform, and amiable to large scale malaria surveillance studies and malaria control and elimination programs. Further field validation of this novel primer will be helpful to ascertain the utility for large scale malaria screening programs.
[Mh] Termos MeSH primário: Primers do DNA/genética
Luz
Técnicas de Diagnóstico Molecular/métodos
Plasmodium ovale/genética
Plasmodium ovale/isolamento & purificação
Reação em Cadeia da Polimerase em Tempo Real/métodos
[Mh] Termos MeSH secundário: Transporte de Elétrons/efeitos da radiação
Seres Humanos
Limite de Detecção
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA Primers)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179178


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[PMID]:28438137
[Au] Autor:Gunawardena S; Daniels RF; Yahathugoda TC; Weerasooriya MV; Durfee K; Volkman SK; Wirth DF; Karunaweera ND
[Ad] Endereço:Department of Parasitology, Faculty of Medicine, University of Colombo, 25, Kynsey Road, Colombo 8, Sri Lanka.
[Ti] Título:Case report of Plasmodium ovale curtisi malaria in Sri Lanka: relevance for the maintenance of elimination status.
[So] Source:BMC Infect Dis;17(1):307, 2017 Apr 24.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Following its recent certification as malaria-free, imported infections now pose the greatest threat for maintaining this status in Sri Lanka. Imported infections may also introduce species that are uncommon or not previously endemic to these areas. We highlight in this case report the increasing importance of less common malaria species such as Plasmodium ovale in elimination settings and discuss its relevance for the risk of malaria resurgence in the country. CASE PRESENTATION: A 41-year-old patient from southern Sri Lanka was diagnosed with malaria after 8 days of fever. Microscopy of blood smears revealed parasites morphologically similar to P. vivax and the rapid diagnostic test was indicative of non-P. falciparum malaria. He was treated with chloroquine over 3 days and primaquine for 14 days. He was negative for malaria at a one-year follow-up. Molecular testing performed subsequently confirmed that infection was caused by P. ovale curtisi. The patient gave a history of P. vivax malaria treated with chloroquine and primaquine. He also provided a history of travel to malaria endemic regions, including residing in Liberia from May 2012 to November 2013, throughout which he was on weekly malaria prophylaxis with mefloquine. He had also visited India on an eight-day Buddhist pilgrimage tour in September 2014 without malaria prophylaxis. CONCLUSIONS: It is crucial that every case of malaria is investigated thoroughly and necessary measures taken to prevent re-introduction of malaria. Accurate molecular diagnostic techniques need to be established in Sri Lanka for the screening and diagnosis of all species of human malaria infections, especially those that may occur with low parasitemia and are likely to be undetected using the standard techniques currently in use. In addition, ascertaining whether an infection occurred through local transmission or by importation is critical in the implementation of an effective plan of action in the country. This new era emphasizes the global nature of regional malaria elimination. Increasing global surveillance and tool development are necessary in order to "fingerprint" parasites and identify their origin.
[Mh] Termos MeSH primário: Antimaláricos/uso terapêutico
Malária Vivax/parasitologia
Malária/diagnóstico
Plasmodium ovale/isolamento & purificação
[Mh] Termos MeSH secundário: Adulto
Cloroquina/uso terapêutico
Febre
Seres Humanos
Libéria
Malária/tratamento farmacológico
Malária/epidemiologia
Malária/parasitologia
Malária Vivax/tratamento farmacológico
Masculino
Técnicas de Diagnóstico Molecular
Parasitemia
Plasmodium ovale/genética
Primaquina/uso terapêutico
Risco
Sri Lanka/epidemiologia
Viagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimalarials); 886U3H6UFF (Chloroquine); MVR3634GX1 (Primaquine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170426
[St] Status:MEDLINE
[do] DOI:10.1186/s12879-017-2411-z


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[PMID]:28423028
[Au] Autor:Srisutham S; Saralamba N; Malleret B; Rénia L; Dondorp AM; Imwong M
[Ad] Endereço:Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
[Ti] Título:Four human Plasmodium species quantification using droplet digital PCR.
[So] Source:PLoS One;12(4):e0175771, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Droplet digital polymerase chain reaction (ddPCR) is a partial PCR based on water-oil emulsion droplet technology. It is a highly sensitive method for detecting and delineating minor alleles from complex backgrounds and provides absolute quantification of DNA targets. The ddPCR technology has been applied for detection of many pathogens. Here the sensitive assay utilizing ddPCR for detection and quantification of Plasmodium species was investigated. The assay was developed for two levels of detection, genus specific for all Plasmodium species and for specific Plasmodium species detection. The ddPCR assay was developed based on primers and probes specific to the Plasmodium genus 18S rRNA gene. Using ddPCR for ultra-sensitive P. falciparum assessment, the lower level of detection from concentrated DNA obtained from a high volume (1 mL) blood sample was 11 parasites/mL. For species identification, in particular for samples with mixed infections, a duplex reaction was developed for detection and quantification P. falciparum/ P. vivax and P. malariae/ P. ovale. Amplification of each Plasmodium species in the duplex reaction showed equal sensitivity to singleplex single species detection. The duplex ddPCR assay had higher sensitivity to identify minor species in 32 subpatent parasitaemia samples from Cambodia, and performed better than real-time PCR. The ddPCR assay shows high sensitivity to assess very low parasitaemia of all human Plasmodium species. This provides a useful research tool for studying the role of the asymptomatic parasite reservoir for transmission in regions aiming for malaria elimination.
[Mh] Termos MeSH primário: DNA de Protozoário/genética
Malária Falciparum/diagnóstico
Malária Vivax/diagnóstico
Malária/diagnóstico
Reação em Cadeia da Polimerase Multiplex/métodos
Parasitemia/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Camboja
Diagnóstico Diferencial
Emulsões
Feminino
Seres Humanos
Malária/parasitologia
Malária Falciparum/parasitologia
Malária Vivax/parasitologia
Masculino
Meia-Idade
Parasitemia/parasitologia
Plasmodium falciparum/genética
Plasmodium falciparum/isolamento & purificação
Plasmodium malariae/genética
Plasmodium malariae/isolamento & purificação
Plasmodium ovale/genética
Plasmodium ovale/isolamento & purificação
Plasmodium vivax/genética
Plasmodium vivax/isolamento & purificação
RNA Ribossômico 18S/genética
Reação em Cadeia da Polimerase em Tempo Real
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Protozoan); 0 (Emulsions); 0 (RNA, Ribosomal, 18S)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170506
[Lr] Data última revisão:
170506
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0175771


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[PMID]:28284211
[Au] Autor:Groger M; Fischer HS; Veletzky L; Lalremruata A; Ramharter M
[Ad] Endereço:Division of Infectious Diseases and Tropical Medicine, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
[Ti] Título:A systematic review of the clinical presentation, treatment and relapse characteristics of human Plasmodium ovale malaria.
[So] Source:Malar J;16(1):112, 2017 Mar 11.
[Is] ISSN:1475-2875
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Despite increased efforts to control and ultimately eradicate human malaria, Plasmodium ovale malaria is for the most part outside the focus of research or public health programmes. Importantly, the understanding of P. ovale-nowadays regarded as the two distinct species P. ovale wallikeri and P. ovale curtisi-largely stems from case reports and case series lacking study designs providing high quality evidence. Consecutively, there is a lack of systematic evaluation of the clinical presentation, appropriate treatment and relapse characteristics of P. ovale malaria. The aim of this systematic review is to provide a systematic appraisal of the current evidence for severe manifestations, relapse characteristics and treatment options for human P. ovale malaria. METHODS AND RESULTS: This systematic review was performed according to the PRISMA guidelines and registered in the international prospective register for systematic reviews (PROSPERO 2016:CRD42016039214). P. ovale mono-infection was a strict inclusion criterion. Of 3454 articles identified by the literature search, 33 articles published between 1922 and 2015 met the inclusion criteria. These articles did not include randomized controlled trials. Five prospective uncontrolled clinical trials were performed on a total of 58 participants. P. ovale was sensitive to all tested drugs within the follow-up periods and on interpretable in vitro assays. Since its first description in 1922, only 18 relapsing cases of P. ovale with a total of 28 relapse events were identified in the scientific literature. There was however no molecular evidence for a causal relationship between dormant liver stages and subsequent relapses. A total of 22 severe cases of P. ovale malaria were published out of which five were fatal. Additionally, two cases of congenital P. ovale malaria were reported. CONCLUSIONS: Current knowledge of P. ovale malaria is based on small trials with minor impact, case reports and clinical observations. This systematic review highlights that P. ovale is capable of causing severe disease, severe congenital malaria and may even lead to death. Evidence for relapses in patients with P. ovale malaria adds up to only a handful of cases. Nearly 100 years after P. ovale's first description by Stephens the evidence for the clinical characteristics, relapse potential and optimal treatments for P. ovale malaria is still scarce.
[Mh] Termos MeSH primário: Antimaláricos/uso terapêutico
Malária/tratamento farmacológico
Malária/patologia
Plasmodium ovale/isolamento & purificação
[Mh] Termos MeSH secundário: Antimaláricos/farmacologia
Seres Humanos
Malária/parasitologia
Plasmodium ovale/efeitos dos fármacos
Recidiva
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antimalarials)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170313
[St] Status:MEDLINE
[do] DOI:10.1186/s12936-017-1759-2


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[PMID]:28140603
[Au] Autor:Armed Forces Health Surveillance Branch
[Ti] Título:Update: Malaria, U.S. Armed Forces, 2016.
[So] Source:MSMR;24(1):2-7, 2017 Jan.
[Is] ISSN:2152-8217
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Malaria infection remains an important health threat to U.S. service members who are located in endemic areas because of long-term duty assignments, participation in shorter-term contingency operations, or personal travel. In 2016, 57 service members were diagnosed with or reported to have malaria, which is the highest number of cases since 2011 (n=124). The relatively low numbers of cases during 2012-2016 mainly reflect decreases in cases acquired in Afghanistan, a reduction due largely to the progressive withdrawal of U.S. forces from that country. The percentage of cases of malaria caused by (26.3%; n=15) in 2016 was the highest since 2012. The percentages of cases caused by (45.6%; n=26), by and (3.5%, n=2), and by unspecified agents (24.6%; n=14) remained similar to those of the preceding 4 years. Malaria was diagnosed at or reported from 25 different medical facilities in the U.S., Afghanistan, Germany, Korea, Djibouti, and Oman. Providers of medical care to military members should be knowledgeable of, and vigilant for, clinical manifestations of malaria outside of endemic areas.
[Mh] Termos MeSH primário: Malária/epidemiologia
Militares/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Incidência
Malária/diagnóstico
Malária/prevenção & controle
Masculino
Meia-Idade
Plasmodium falciparum
Plasmodium ovale
Plasmodium vivax
Vigilância da População
Risco
Estados Unidos/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170602
[Lr] Data última revisão:
170602
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170201
[St] Status:MEDLINE


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[PMID]:28117441
[Au] Autor:Rutledge GG; Böhme U; Sanders M; Reid AJ; Cotton JA; Maiga-Ascofare O; Djimdé AA; Apinjoh TO; Amenga-Etego L; Manske M; Barnwell JW; Renaud F; Ollomo B; Prugnolle F; Anstey NM; Auburn S; Price RN; McCarthy JS; Kwiatkowski DP; Newbold CI; Berriman M; Otto TD
[Ad] Endereço:Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
[Ti] Título:Plasmodium malariae and P. ovale genomes provide insights into malaria parasite evolution.
[So] Source:Nature;542(7639):101-104, 2017 02 02.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Elucidation of the evolutionary history and interrelatedness of Plasmodium species that infect humans has been hampered by a lack of genetic information for three human-infective species: P. malariae and two P. ovale species (P. o. curtisi and P. o. wallikeri). These species are prevalent across most regions in which malaria is endemic and are often undetectable by light microscopy, rendering their study in human populations difficult. The exact evolutionary relationship of these species to the other human-infective species has been contested. Using a new reference genome for P. malariae and a manually curated draft P. o. curtisi genome, we are now able to accurately place these species within the Plasmodium phylogeny. Sequencing of a P. malariae relative that infects chimpanzees reveals similar signatures of selection in the P. malariae lineage to another Plasmodium lineage shown to be capable of colonization of both human and chimpanzee hosts. Molecular dating suggests that these host adaptations occurred over similar evolutionary timescales. In addition to the core genome that is conserved between species, differences in gene content can be linked to their specific biology. The genome suggests that P. malariae expresses a family of heterodimeric proteins on its surface that have structural similarities to a protein crucial for invasion of red blood cells. The data presented here provide insight into the evolution of the Plasmodium genus as a whole.
[Mh] Termos MeSH primário: Evolução Molecular
Genoma/genética
Malária/parasitologia
Plasmodium malariae/genética
Plasmodium ovale/genética
[Mh] Termos MeSH secundário: Animais
Eritrócitos/parasitologia
Feminino
Genômica
Seres Humanos
Pan troglodytes/parasitologia
Filogenia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE
[do] DOI:10.1038/nature21038


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[PMID]:28061871
[Au] Autor:Cuadros J; Martin Ramírez A; González IJ; Ding XC; Perez Tanoira R; Rojo-Marcos G; Gómez-Herruz P; Rubio JM
[Ad] Endereço:Department of Clinical Microbiology and Parasitology, Hospital Príncipe de Asturias, 28805, Alcalá de Henares, Madrid, Spain. jcuadros48@gmail.com.
[Ti] Título:LAMP kit for diagnosis of non-falciparum malaria in Plasmodium ovale infected patients.
[So] Source:Malar J;16(1):20, 2017 Jan 07.
[Is] ISSN:1475-2875
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Microscopy and rapid diagnosis tests have a limited sensitivity in diagnosis of malaria by Plasmodium ovale. The LAMP kit (LoopAMP®) can be used in the field without special equipment and could have an important role in malaria control programmes in endemic areas and for malaria diagnosis in returned travellers. The performance of the Pan primer of the kit in detecting malaria by P. ovale was compared with the results of standard nPCR in samples of patients returning from P. ovale endemic areas. METHODS: Plasmodium ovale positive samples (29, tested by PCR and/or microscopy) and malaria negative specimens (398, tested by microscopy and PCR) were collected in different hospitals of Europe from June 2014 to March 2016 and frozen at -20 °C. Boil and spin method was used to extract DNA from all samples and amplification was performed with LoopAMP® MALARIA kit (Eiken Chemical, Japan) in an automated turbidimeter (Eiken 500). The results of LAMP read by turbidimetry and with the naked eye were compared. RESULTS: The kit showed a sensitivity of 100% and a specificity of 97.24% with positive and negative predictive values of 72.5 and 100%, respectively. Naked eyed readings were in accordance with turbidimetry readings (sensitivity, 92.5%, specificity, 98.96% and positive and negative predictive values, respectively, 90.24 and 99.22%). The limit of detection of LAMP assay for P. ovale was between 0.8 and 2 parasites/µl. CONCLUSIONS: The Pan primer of the Malaria kit LoopAMP® can detect P. ovale at very low-levels and showed a predictive negative value of 100%. This tool can be useful in malaria control and elimination programmes and in returned travellers from P. ovale endemic areas. Naked eye readings are equivalent to automated turbidimeter readings in specimens obtained with EDTA.
[Mh] Termos MeSH primário: Malária/diagnóstico
Malária/parasitologia
Técnicas de Diagnóstico Molecular/métodos
Técnicas de Amplificação de Ácido Nucleico/métodos
Plasmodium ovale/isolamento & purificação
[Mh] Termos MeSH secundário: Europa (Continente)
Seres Humanos
Plasmodium ovale/genética
Valor Preditivo dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170608
[Lr] Data última revisão:
170608
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170108
[St] Status:MEDLINE
[do] DOI:10.1186/s12936-016-1669-8


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[PMID]:28049489
[Au] Autor:Daniels RF; Deme AB; Gomis JF; Dieye B; Durfee K; Thwing JI; Fall FB; Ba M; Ndiop M; Badiane AS; Ndiaye YD; Wirth DF; Volkman SK; Ndiaye D
[Ad] Endereço:Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, Boston, MA, USA. rdaniels@hsph.harvard.edu.
[Ti] Título:Evidence of non-Plasmodium falciparum malaria infection in Kédougou, Sénégal.
[So] Source:Malar J;16(1):9, 2017 Jan 03.
[Is] ISSN:1475-2875
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Expanded malaria control efforts in Sénégal have resulted in increased use of rapid diagnostic tests (RDT) to identify the primary disease-causing Plasmodium species, Plasmodium falciparum. However, the type of RDT utilized in Sénégal does not detect other malaria-causing species such as Plasmodium ovale spp., Plasmodium malariae, or Plasmodium vivax. Consequently, there is a lack of information about the frequency and types of malaria infections occurring in Sénégal. This study set out to better determine whether species other than P. falciparum were evident among patients evaluated for possible malaria infection in Kédougou, Sénégal. METHODS: Real-time polymerase chain reaction speciation assays for P. vivax, P. ovale spp., and P. malariae were developed and validated by sequencing and DNA extracted from 475 Plasmodium falciparum-specific HRP2-based RDT collected between 2013 and 2014 from a facility-based sample of symptomatic patients from two health clinics in Kédougou, a hyper-endemic region in southeastern Sénégal, were analysed. RESULTS: Plasmodium malariae (n = 3) and P. ovale wallikeri (n = 2) were observed as co-infections with P. falciparum among patients with positive RDT results (n = 187), including one patient positive for all three species. Among 288 negative RDT samples, samples positive for P. falciparum (n = 24), P. ovale curtisi (n = 3), P. ovale wallikeri (n = 1), and P. malariae (n = 3) were identified, corresponding to a non-falciparum positivity rate of 2.5%. CONCLUSIONS: These findings emphasize the limitations of the RDT used for malaria diagnosis and demonstrate that non-P. falciparum malaria infections occur in Sénégal. Current RDT used for routine clinical diagnosis do not necessarily provide an accurate reflection of malaria transmission in Kédougou, Sénégal, and more sensitive and specific methods are required for diagnosis and patient care, as well as surveillance and elimination activities. These findings have implications for other malaria endemic settings where species besides P. falciparum may be transmitted and overlooked by control or elimination activities.
[Mh] Termos MeSH primário: Malária/epidemiologia
Plasmodium malariae/isolamento & purificação
Plasmodium ovale/isolamento & purificação
Plasmodium vivax/isolamento & purificação
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Criança
Pré-Escolar
Testes Diagnósticos de Rotina/métodos
Feminino
Seres Humanos
Lactente
Masculino
Meia-Idade
Plasmodium malariae/classificação
Plasmodium malariae/genética
Plasmodium ovale/classificação
Plasmodium ovale/genética
Plasmodium vivax/classificação
Plasmodium vivax/genética
Prevalência
Reação em Cadeia da Polimerase em Tempo Real
Senegal/epidemiologia
Sensibilidade e Especificidade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170622
[Lr] Data última revisão:
170622
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170105
[St] Status:MEDLINE
[do] DOI:10.1186/s12936-016-1661-3


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[PMID]:27887819
[Au] Autor:Zidouh S; Jidane S; Belkouch A; Bekkali H; Belyamani L
[Ad] Endereço:Emergency department, military hospital Mohammed V Rabat, Morocco. Electronic address: sazi26@hotmail.fr.
[Ti] Título:Spontaneous splenic rupture from Plasmodium ovalae malaria.
[So] Source:Am J Emerg Med;35(2):347-349, 2017 Feb.
[Is] ISSN:1532-8171
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Artemisininas/uso terapêutico
Etanolaminas/uso terapêutico
Fluorenos/uso terapêutico
Malária/complicações
Plasmodium ovale/isolamento & purificação
Esplenectomia
Ruptura Esplênica/etiologia
[Mh] Termos MeSH secundário: Abdome/diagnóstico por imagem
Adulto
África Central/epidemiologia
Antimaláricos/uso terapêutico
Quimioterapia Combinada
Doenças Endêmicas
Seres Humanos
Laparoscopia
Malária/diagnóstico
Malária/tratamento farmacológico
Malária/epidemiologia
Masculino
Ruptura Esplênica/diagnóstico
Ruptura Esplênica/cirurgia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Nm] Nome de substância:
0 (Antimalarials); 0 (Artemisinins); 0 (Ethanolamines); 0 (Fluorenes); C7D6T3H22J (artemether); F38R0JR742 (lumefantrine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161127
[St] Status:MEDLINE


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[PMID]:27825828
[Au] Autor:Auburn S; Barry AE
[Ad] Endereço:Global and Tropical Health Division, Menzies School of Health Research, Darwin, Australia.
[Ti] Título:Dissecting malaria biology and epidemiology using population genetics and genomics.
[So] Source:Int J Parasitol;47(2-3):77-85, 2017 Feb.
[Is] ISSN:1879-0135
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Molecular approaches have an increasingly recognized utility in surveillance of malaria parasite populations, not only in defining prevalence and incidence with higher sensitivity than traditional methods, but also in monitoring local and regional parasite transmission patterns. In this review, we provide an overview of population genetic and genomic studies of human-infecting Plasmodium species, highlighting recent advances in the field. In accordance with the renewed impetus for malaria eradication, many studies are now using genetic and genomic epidemiology to support local evidence-based intervention strategies. Microsatellite genotyping remains a popular approach for both Plasmodium falciparum and Plasmodium vivax. However, with the increasing availability of whole genome sequencing data enabling effective single nucleotide polymorphism-based panels tailored to a given study question and setting, this approach is gaining popularity. The availability of new reference genomes for Plasmodium malariae and Plasmodium ovale should see a surge in similar molecular studies on these currently neglected species. Genomic studies are revealing new insights into important adaptive mechanisms of the parasite including antimalarial drug resistance. The advent of new methodologies such as selective whole genome amplification for dealing with extensive human DNA in low density field isolates should see genome-wide approaches becoming routine for parasite surveillance once the economic costs outweigh the current cost benefits of targeted approaches.
[Mh] Termos MeSH primário: Malária Falciparum/parasitologia
Malária Vivax/parasitologia
Plasmodium ovale/genética
Plasmodium vivax/genética
[Mh] Termos MeSH secundário: Genética Populacional
Genoma de Protozoário
Seres Humanos
Malária Falciparum/epidemiologia
Malária Falciparum/transmissão
Malária Vivax/epidemiologia
Malária Vivax/transmissão
Epidemiologia Molecular
Tipagem Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170512
[Lr] Data última revisão:
170512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161110
[St] Status:MEDLINE



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