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[PMID]:29304171
[Au] Autor:Galán A; Mayer I; Rafaj RB; Bendelja K; Susic V; Cerón JJ; Mrljak V
[Ad] Endereço:ERA Chair project ''VetMedZg'', Clinic for Internal Diseases, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia.
[Ti] Título:MCP-1, KC-like and IL-8 as critical mediators of pathogenesis caused by Babesia canis.
[So] Source:PLoS One;13(1):e0190474, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Canine babesiosis caused by the intraerythrocytic protozoan parasite Babesia canis is a tick-borne disease characterized by a host response that involves both cellular and humoral immunity. This study focuses on the secretion of cytokines Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), Keratinocyte Chemotactic-like (KC-like), Interleukins (IL)-2, IL-7, IL-8, IL-10, IL-15, IL-18 and Monocyte Chemotactic Protein-1 (MCP-1) in babesiosis caused by Babesia canis upon treatment with Imizol®. We assessed time dependent changes in cytokine levels and tested whether these changes correlate with pathogenesis of the disease. Sixteen healthy dogs and 31 dogs infected with Babesia canis, of which 18 showed complications, were treated with Imizol®. One dog died during the study (3.2%). Longitudinal study was perfomed by monitoring dogs at the first day of presentation (day 1) and 6 days later (day 7). Our results show that higher MCP-1 levels on day 1 are positively associated with the occurrence of complications, (complicated vs. uncomplicated; p = 0.00016). A similar pattern was observed for KC-like on day 1 (p = 0.0326) and day 7 (p = 0.044). Moreover, babesiosis caused by B. canis produced a steady increase in IL-8 levels with a moderate to strong negative correlation with erythrocyte counts and hematocrit in uncomplicated diseased dogs only (Spearman's rank correlation coefficient rs = -0.582 and rs = -0.598 respectively). Like for MCP-1, KC-like levels also differed in complicated and uncomplicated diseased dogs on day 1 (p = 0.03236) and day 7 (p = 0.044). Furthermore, KC-like levels were strongly correlated with IL-8 levels (rs = 0.663-0.7) and non-segmented neutrophil counts (rs = 0.572-0.732) in both diseased groups. Analysis of ROC suggests the use of serum levels of MCP-1 and IL-7 as predictors of the occurrence of complications with an AUC of 0.906 and 0.896 respectively and linear combinations of MCP-1, KC-Like, IL-7 and GM-CSF with values up to AUC = 0.983. Cytokine cluster analysis presented in this study can contribute to a better understanding of the pathogenesis of babesiosis and serve as a prognostic tool for the early detection of cases with highest likelihood of developing complications. Overall, our studies show that infection by B. canis elicits a cytokine pattern that is distinct from that observed with B. rossi, and that some of the inflammatory mediators can be useful to predict complications. Our results also suggest targets for the development of novel therapeutic strategies in babesiosis caused by B. canis.
[Mh] Termos MeSH primário: Babesia/patogenicidade
Babesiose/fisiopatologia
Quimiocina CCL2/secreção
Quimiocinas/fisiologia
Doenças do Cão/fisiopatologia
Fator Estimulador de Colônias de Granulócitos e Macrófagos/secreção
Interleucina-8/secreção
[Mh] Termos MeSH secundário: Animais
Babesiose/parasitologia
Quimiocina CCL2/fisiologia
Doenças do Cão/parasitologia
Cães
Fator Estimulador de Colônias de Granulócitos e Macrófagos/fisiologia
Interleucina-8/fisiologia
Estudos Longitudinais
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Chemokine CCL2); 0 (Chemokines); 0 (Interleukin-8); 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190474


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[PMID]:29022768
[Au] Autor:Morganti G; Gavaudan S; Canonico C; Ravagnan S; Olivieri E; Diaferia M; Marenzoni ML; Antognoni MT; Capelli G; Silaghi C; Veronesi F
[Ad] Endereço:1 Department of Veterinary Medicine, University of Perugia , Perugia, Italy .
[Ti] Título:Molecular Survey on Rickettsia spp., Anaplasma phagocytophilum, Borrelia burgdorferi Sensu Lato, and Babesia spp. in Ixodes ricinus Ticks Infesting Dogs in Central Italy.
[So] Source:Vector Borne Zoonotic Dis;17(11):743-748, 2017 Nov.
[Is] ISSN:1557-7759
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Dogs are a common feeding hosts for Ixodes ricinus and may act as reservoir hosts for zoonotic tick-borne pathogens (TBPs) and as carriers of infected ticks into human settings. The aim of this work was to evaluate the presence of several selected TBPs of significant public health concern by molecular methods in I. ricinus recovered from dogs living in urban and suburban settings in central Italy. A total of 212 I. ricinus specimens were collected from the coat of domestic dogs. DNA was extracted from each specimen individually and tested for Rickettsia spp., Borrelia burgdorferi sensu lato, Babesia spp., and Anaplasma phagocytophilum, using real-time and conventional PCR protocols, followed by sequencing. Sixty-one ticks (28.8%) tested positive for TBPs; 57 samples were infected by one pathogen, while four showed coinfections. Rickettsia spp. was detected in 39 specimens (18.4%), of which 32 were identified as Rickettsia monacensis and seven as Rickettsia helvetica. Twenty-two samples (10.4%) tested positive for A. phagocytophilum; Borrelia lusitaniae and Borrelia afzelii were detected in two specimens and one specimen, respectively. One tick (0.5%) was found to be positive for Babesia venatorum (EU1). Our findings reveal the significant exposure of dogs to TBPs of public health concern and provide data on the role of dogs in the circulation of I. ricinus-borne pathogens in central Italy.
[Mh] Termos MeSH primário: Anaplasma phagocytophilum/isolamento & purificação
Babesia/isolamento & purificação
Grupo Borrelia Burgdorferi/isolamento & purificação
Doenças do Cão/parasitologia
Ixodes/microbiologia
Rickettsia/isolamento & purificação
[Mh] Termos MeSH secundário: Anaplasma phagocytophilum/genética
Animais
Babesia/genética
Grupo Borrelia Burgdorferi/genética
DNA Bacteriano/genética
DNA de Protozoário/genética
Doenças do Cão/epidemiologia
Cães
Feminino
Itália/epidemiologia
Masculino
Ninfa
Rickettsia/genética
Infestações por Carrapato/epidemiologia
Infestações por Carrapato/parasitologia
Infestações por Carrapato/veterinária
Zoonoses
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (DNA, Protozoan)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171013
[St] Status:MEDLINE
[do] DOI:10.1089/vbz.2017.2154


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[PMID]:28832147
[Au] Autor:Badral D; Odonbayar B; Murata T; Munkhjargal T; Tuvshintulga B; Igarashi I; Suganuma K; Inoue N; Brantner AH; Odontuya G; Sasaki K; Batkhuu J
[Ad] Endereço:School of Engineering and Applied Sciences, National University of Mongolia , Ulaanbaatar 14201, Mongolia.
[Ti] Título:Flavonoid and Galloyl Glycosides Isolated from Saxifraga spinulosa and Their Antioxidative and Inhibitory Activities against Species That Cause Piroplasmosis.
[So] Source:J Nat Prod;80(9):2416-2423, 2017 Sep 22.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Eight new flavonoid-based 3'-O-ß-d-glucopyranosides (1-8) and three new galloyl glucosides (9, 11, 12), were isolated from the aerial parts of Saxifraga spinulosa, along with 25 known compounds. The structures of the new compounds were elucidated by spectroscopic methods. Most of the isolated compounds exhibited potent DPPH radical-scavenging activities. Further, their inhibitory activities were evaluated against Babesia bovis, Babesia bigemina, Babesia caballi, and Theileria equi, protozoan parasites that cause piroplasmosis in livestock. The results indicated that several of these compounds showed growth-inhibitory effects on such organisms that cause piroplasmosis.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Babesia/química
Flavonoides/farmacologia
Glicosídeos/farmacologia
Saxifragaceae/química
Theileria/química
[Mh] Termos MeSH secundário: Animais
Antioxidantes/química
Flavonoides/química
Glicosídeos/química
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Flavonoids); 0 (Glycosides)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.7b00142


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[PMID]:28722598
[Au] Autor:Mareedu N; Schotthoefer AM; Tompkins J; Hall MC; Fritsche TR; Frost HM
[Ad] Endereço:Marshfield Clinic Health System, Marshfield, Wisconsin.
[Ti] Título:Risk Factors for Severe Infection, Hospitalization, and Prolonged Antimicrobial Therapy in Patients with Babesiosis.
[So] Source:Am J Trop Med Hyg;97(4):1218-1225, 2017 Oct.
[Is] ISSN:1476-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Babesiosis is an emerging tick-borne disease transmitted by the hard tick , which also transmits Lyme disease. Better gradation of prognostic indicators are needed to determine which patients may develop serious complications requiring hospitalization, and to provide early guidance on appropriate therapy. In this study, we evaluated 128 patients with smear or real time polymerase chain reaction-confirmed infections over a period of 16 years. Patients with asplenia or immunocompromising conditions were more likely to have severe infection ( < 0.01), require hospitalization ( < 0.01), or receive prolonged courses of antimicrobials ( < 0.01). Nausea or vomiting ( < 0.01) and diarrhea ( < 0.01) along with hyperbilirubinemia ( < 0.01) were predictive of severe infection, hospitalization, and prolonged antimicrobial therapy. Patients with concurrent Lyme disease were less likely to require hospitalization and had similar severity of disease and length of antibiotic treatment compared with those without Lyme disease.
[Mh] Termos MeSH primário: Antiprotozoários/administração & dosagem
Antiprotozoários/uso terapêutico
Babesiose/tratamento farmacológico
Babesiose/patologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Babesia/isolamento & purificação
Babesiose/epidemiologia
Esquema de Medicação
Feminino
Seres Humanos
Masculino
Meia-Idade
Fatores de Risco
Picadas de Carrapatos
Wisconsin/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiprotozoal Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170720
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.17-0146


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[PMID]:28655583
[Au] Autor:Rizk MA; El-Sayed SAE; AbouLaila M; Yokoyama N; Igarashi I
[Ad] Endereço:National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-Cho, Obihiro, Hokkaido, Japan; Department of Internal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt.
[Ti] Título:Evaluation of the inhibitory effect of N-acetyl-L-cysteine on Babesia and Theileria parasites.
[So] Source:Exp Parasitol;179:43-48, 2017 Aug.
[Is] ISSN:1090-2449
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:N-acetyl-L-cysteine is known to have antibacterial, antiviral, antimalarial, and antioxidant activities. Therefore, the in vitro inhibitory effect of this hit was evaluated in the present study on the growth of Babesia and Theileria parasites. The in vitro growth of Babesia bovis, Babesia bigemina, Babesia divergens, Theileria equi, and Babesia caballi that were tested was significantly inhibited (P < 0.05) by micromolar concentrations of N-acetyl-L-cysteine. The inhibitory effect of N-acetyl-L-cysteine was synergistically potentiated when used in combination with diminazene aceturate on B. bovis and B. caballi cultures. These results indicate that N-acetyl-L-cysteine might be used as a drug for the treatment of babesiosis, especially when used in combination with diminazene aceturate.
[Mh] Termos MeSH primário: Acetilcisteína/farmacologia
Antiprotozoários/farmacologia
Babesia/efeitos dos fármacos
Diminazena/análogos & derivados
Theileria/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Babesia/crescimento & desenvolvimento
Babesia bovis/efeitos dos fármacos
Babesia bovis/crescimento & desenvolvimento
Bovinos
Diminazena/farmacologia
Sinergismo Farmacológico
Eritrócitos/parasitologia
Cavalos
Concentração Inibidora 50
Espectrometria de Fluorescência
Theileria/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiprotozoal Agents); JI8SAD85NO (diminazene aceturate); WYQ7N0BPYC (Acetylcysteine); Y5G36EEA5Z (Diminazene)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170629
[St] Status:MEDLINE


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[PMID]:28570038
[Au] Autor:Adamska M; Skotarczak B
[Ad] Endereço:Department of Genetics, Faculty of Biology, Szczecin University, ul. Felczaka 3c, 71-412 Szczecin, Poland
[Ti] Título:Molecular detecting of piroplasms in feeding and questing Ixodes ricinus ticks
[So] Source:Ann Parasitol;63(1):21-26, 2017.
[Is] ISSN:2299-0631
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:The purpose of this study was to detect piroplasms, which are pathogens of veterinary and zoonotic importance in ticks, that were collected from ponies and field vegetation and to determine the role of Shetland ponies as potential reservoir hosts for piroplasms. A total of 1737 feeding and 371 questing Ixodes ricinus collected from horses or vegetation were tested for the presence of Babesia and Theileria DNA. Piroplasm 18S rRNA gene amplification was conducted, and the obtained amplicons were sequenced. Babesia DNA was detected in only three ticks (one tick collected from a pony and two collected from vegetation), and all of the obtained sequences had 100% similarity to B. divergens. Theileria DNA was not present in the examined ticks. Thus, the above results indicate that ponies are probably not essential hosts for the detected species of piroplasms. Piroplasm species typical for horses (Babesia caballi and Theileria equi) were not detected because I. ricinus is not their vector. The low infection rate of I. ricinus with B. divergens shows that the disease risk for the local horse population and people associated with pony horses is low, but it demonstrates their possible role as a source of human infection in northern Poland.
[Mh] Termos MeSH primário: Babesia/isolamento & purificação
Comportamento Alimentar/fisiologia
Doenças dos Cavalos/parasitologia
Ixodes/parasitologia
Infestações por Carrapato/veterinária
[Mh] Termos MeSH secundário: Animais
Babesia/genética
DNA de Protozoário/isolamento & purificação
Cavalos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Protozoan)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170706
[Lr] Data última revisão:
170706
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE
[do] DOI:10.17420/ap6301.80


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[PMID]:28438201
[Au] Autor:Crnogaj M; Cerón JJ; Smit I; Kis I; Gotic J; Brkljacic M; Matijatko V; Rubio CP; Kucer N; Mrljak V
[Ad] Endereço:Clinic for Internal Diseases, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia.
[Ti] Título:Relation of antioxidant status at admission and disease severity and outcome in dogs naturally infected with Babesia canis canis.
[So] Source:BMC Vet Res;13(1):114, 2017 Apr 24.
[Is] ISSN:1746-6148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Canine babesiosis is caused by species of the Babesia genus and has become an emerging disease worldwide. To the authors' knowledge there are no reports in which antioxidants have been analyzed in different presentations of canine babesiosis or in which the prognostic value of antioxidants has been studied. The aim of this study was to evaluate whether oxidative stress could be related to the severity and outcome of canine babesiosis. For this purpose a profile consisting of four antioxidant biomarkers (superoxide dismutase - SOD, glutathione peroxidase - GPx, catalase, total antioxidant status - TAS) and malondialdehyde - MDA as an oxidant biomarker (previously evaluated, here studied for comparative purposes) were evaluated in dogs with canine babesiosis of different clinical severity and outcomes. RESULTS: The study was conducted with a sample of 40 dogs suffering from babesiosis (further divided into uncomplicated, one complication and multiple organ dysfunction syndrome - MODS group) and 30 healthy dogs (control group). Additionally, the babesiosis group was divided according to the anaemia into non-anaemic, mildly anaemic, moderately anaemic and severely anaemic dogs. The results of our study showed significantly decreased SOD, catalase and TAS values in diseased dogs compared to controls, while there were no significant differences in GPx between these groups. Dogs that developed MODS showed lower activities of SOD and GPx and higher MDA values compared to dogs with uncomplicated babesiosis as well as with dogs that developed one complication. Superoxide dismutase, catalase and GPx were negatively correlated whereas MDA was positively correlated with the lethal outcome of the disease. Furthermore, this study detected more pronounced decrease in antioxidant biomarkers (SOD, GPx and catalase) in dogs with moderate anaemia compared to those with mild anaemia. CONCLUSIONS: The results of this study showed changes in biomarkers related to the antioxidant status of dogs naturally infected with B. canis canis. These biomarkers could be used as indicators of disease severity and outcome in dogs suffering from babesiosis.
[Mh] Termos MeSH primário: Antioxidantes/análise
Babesia
Babesiose/sangue
Doenças do Cão/parasitologia
[Mh] Termos MeSH secundário: Animais
Babesiose/metabolismo
Babesiose/mortalidade
Babesiose/parasitologia
Biomarcadores/sangue
Catalase/sangue
Doenças do Cão/sangue
Doenças do Cão/metabolismo
Doenças do Cão/mortalidade
Cães
Feminino
Glutationa Peroxidase/sangue
Masculino
Malondialdeído/sangue
Estresse Oxidativo
Índice de Gravidade de Doença
Superóxido Dismutase/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biomarkers); 4Y8F71G49Q (Malondialdehyde); EC 1.11.1.6 (Catalase); EC 1.11.1.9 (Glutathione Peroxidase); EC 1.15.1.1 (Superoxide Dismutase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170426
[St] Status:MEDLINE
[do] DOI:10.1186/s12917-017-1020-9


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[PMID]:28413078
[Au] Autor:Guswanto A; Allamanda P; Mariamah ES; Munkjargal T; Tuvshintulga B; Takemae H; Sivakumar T; AbouLaila M; Terkawi MA; Ichikawa-Seki M; Nishikawa Y; Yokoyama N; Igarashi I
[Ad] Endereço:National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13 Inada-cho, Obihiro 080-8555, Japan; Balai Veteriner Subang (DIC Subang), Jl. Terusan Garuda 33/11 Blok Werasari Dangdeur, Subang 41212, Indonesia.
[Ti] Título:Evaluation of immunochromatographic test (ICT) strips for the serological detection of Babesia bovis and Babesia bigemina infection in cattle from Western Java, Indonesia.
[So] Source:Vet Parasitol;239:76-79, 2017 May 30.
[Is] ISSN:1873-2550
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Three types of immunochromatographic test (ICT) strips were prepared for the detection of an antibody response against spherical body protein 4 (SBP-4) of Babesia bovis (bovICT), C-terminal-truncated rhoptry-associated protein 1 (rRAP1/CT17) of B. bigemina (bigICT), and the combination of both proteins (dual-ICT). The evaluation of their performance was conducted using a confirmed positive and negative serum panel for B. bovis and B. bigemina. Together with ELISA, the ICT strips were applied to determine the seroprevalence of bovine babesiosis in Western Java, Indonesia. Among 991 serum samples, 28.4%, 25.3%, and 24.5% of cattle were detected to be seropositive to B. bovis infection using ELISA, bovICT, and dual-ICT, respectively. B. bigemina seropositive was detected in 27.1%, 24.2%, and 22.8% of samples using ELISA, bigICT, and dual-ICT, respectively. The comparison of ICT strips and ELISA results using field serum samples showed good agreement with Kappa values >0.7 between all methods The application of ICT strips is preferable in the field situations where rapid diagnosis is required. Furthermore, the data showed the current seroprevalence of bovine babesiosis in Western Java, Indonesia, and efficient control strategies are needed to reduce economic losses due to the disease.
[Mh] Termos MeSH primário: Babesia/classificação
Babesiose/parasitologia
Doenças dos Bovinos/parasitologia
Imunocromatografia/veterinária
[Mh] Termos MeSH secundário: Animais
Babesiose/epidemiologia
Bovinos
Doenças dos Bovinos/epidemiologia
Ensaio de Imunoadsorção Enzimática/veterinária
Indonésia/epidemiologia
Estudos Soroepidemiológicos
Testes Sorológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170418
[St] Status:MEDLINE


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[PMID]:28392045
[Au] Autor:Jouglin M; Perez G; Butet A; Malandrin L; Bastian S
[Ad] Endereço:INRA, UMR1300 Biology, Epidemiology and Risk Analysis in Animal Health, Nantes, France; LUNAM Université, Oniris, UMR BioEpAR, Nantes, France.
[Ti] Título:Low prevalence of zoonotic Babesia in small mammals and Ixodes ricinus in Brittany, France.
[So] Source:Vet Parasitol;238:58-60, 2017 Apr 30.
[Is] ISSN:1873-2550
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In order to evaluate the zoonotic risk due to Babesia spp., especially B. microti, we investigated their presence in 597 individuals of five small mammal species and in 2620 questing nymphs of Ixodes ricinus in rural landscapes of Western France (Brittany). Small mammals (rodents and shrews) are indeed suspected to be reservoir hosts for B. microti, and the tick I. ricinus is the vector of the three main zoonotic species in Europe, i.e. B. divergens, B. venatorum and B. microti. Only one bank vole carried B. microti (genotype "Munich") and only 13 and 2 nymphs of Ixodes ricinus ticks carried B. venatorum and B. capreoli respectively. According to these results, prevalences observed for zoonotic Babesia (0.17% for small mammals and 0.50% for ticks), indicate that exposure of humans to this infectious agent is probably low in western France.
[Mh] Termos MeSH primário: Babesia/isolamento & purificação
Ixodes/parasitologia
Roedores/parasitologia
Musaranhos/parasitologia
[Mh] Termos MeSH secundário: Animais
Vetores Aracnídeos/parasitologia
Reservatórios de Doenças/parasitologia
França
Fatores de Risco
Zoonoses
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170411
[St] Status:MEDLINE


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[PMID]:28378977
[Au] Autor:Zajac V; Wójcik-Fatla A; Sawczyn A; Cisak E; Sroka J; Kloc A; Zajac Z; Buczek A; Dutkiewicz J; Bartosik K
[Ad] Endereço:Department of Health Biohazards and Parasitology, Institute of Rural Health, Lublin, Poland.
[Ti] Título:Prevalence of infections and co-infections with 6 pathogens in Dermacentor reticulatus ticks collected in eastern Poland.
[So] Source:Ann Agric Environ Med;24(1):26-32, 2017 Mar 21.
[Is] ISSN:1898-2263
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Occurrence of co-infections with various pathogens in ixodid ticks creates a risk of increased severity of tick-borne diseases in humans and animals exposed to bite of the ticks carrying multiple pathogens. Accordingly, co-infections in ticks were subject of numerous analyses, but almost exclusively with regard to Ixodes ricinus complex whereas potential tick vectors belonging to other genera were much less studied. Taking into consideration the role of Dermacentor reticulatus in the transmission of various pathogens, we carried out for the first time the comprehensive statistical analysis of co-infections occurring in this tick species. An attempt was made to determine the significance of the associations between 6 different pathogens occurring in D. reticulatus (Tick-borne encephalitis virus = TBEV, Anaplasma phagocytophilum, Rickettsia raoultii, Borrelia burgdorferi s. l., Babesia spp., Toxoplasma gondii), using 2 statistical methods: determination of Odds Ratios (ORs) and the Fisher's exact test. 634 questing Dermacentor reticulatus ticks (370 females and 264 males) were collected in 2011- 2013 by flagging the lower vegetation in 3 localities in the area of Leczynsko-Wlodawskie Lakeland, situated in the Lublin region of eastern Poland. The presence of individual pathogens was detected by PCR. Ticks were infected most often with Rickettsia raoultii (43.8%), less with TBEV (8.5%), and much less with Babesia spp., Toxoplasma gondii, Borrelia burgdorferi s.l., and Anaplasma phagocytophilum (2.5%, 2.1%, 1.6% and 1.1%, respectively). The locality-dependent variability proved to be significant for TBEV (c2=11.063; P=0.004) and Toxoplasma gondii (c2=11.298; P=0.0035), but not for other pathogens. Two hundred seventy (42.6%) of the examined ticks were infected only with a single pathogen, and 54 (8.5%) showed the presence of dual co-infections, each with 2 pathogens. The most common were dual infections with participation of Rickettsia raoultii (7.41%); next, those with participation of the TBEV (5.21%), Toxoplasma gondii (1.58%), Borrelia burgdorferi s.l. (1.26%), Anaplasma phagocytophilum (0.95%), and Babesia spp. (0.63%). On the total number of 15 possible associations, in 9 cases co-infections occurred whereas in 6 cases they were not detected. The most noteworthy were positive co-infections with the participation of TBEV, which proved to be weakly significant (0.05
[Mh] Termos MeSH primário: Dermacentor
[Mh] Termos MeSH secundário: Anaplasma phagocytophilum/isolamento & purificação
Animais
Babesia/isolamento & purificação
Borrelia burgdorferi/isolamento & purificação
Coinfecção
Dermacentor/microbiologia
Dermacentor/parasitologia
Dermacentor/virologia
Vírus da Encefalite Transmitidos por Carrapatos/isolamento & purificação
Feminino
Masculino
Polônia/epidemiologia
Prevalência
Rickettsia/isolamento & purificação
Doenças Transmitidas por Carrapatos/epidemiologia
Doenças Transmitidas por Carrapatos/etiologia
Toxoplasma/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.5604/12321966.1233893



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