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  1 / 2022 MEDLINE  
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[PMID]:29274209
[Au] Autor:Baltaza W; Padzik M; Szaflik JP; Dybicz M; Hendiger E; Chomicz L
[Ad] Endereço:Department of Medical Biology, Medical University of Warsaw, ul. Nowogrodzka 73, 02-018 Warsaw, Poland
[Ti] Título:Amoebicidal or amoebostatic influence of disinfectants used in health facilities and laboratories on corneal strains of Acanthamoeba
[So] Source:Ann Parasitol;63(3):167-172, 2017.
[Is] ISSN:2299-0631
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Different Acanthamoeba species are amphizoic organisms distributed in wide range of habitats in natural and man-made environments; they are also detected on surfaces of equipment and accessories in health facilities. Some strains of the amoebae are causative agents of the vision-threatening human disease Acanthamoeba keratitis, mainly reported in contact lens wearers. An exceptional high resistance of Acanthamoeba trophozoites and particularly cysts to chemicals, disinfectants and drugs is believed as influencing difficulty resulting in unsuccessful therapeutic management. As Acanthamoeba keratitis is the serious medical problem worldwide, different chemicals with possible activity against environmental and clinical Acanthamoeba strains are tested. In our study, selected disinfectants used in health care settings and laboratories were tested and their efficacy against the corneal strains Acanthamoeba castellanii and A. polyphaga , and environmental A. castellanii Neff strain was assessed. Comparative assessment of results of the assays show that, apart from amoebistatic effects, the disinfectants indicated expected cysticidal efficacy.
[Mh] Termos MeSH primário: Ceratite por Acanthamoeba/parasitologia
Acanthamoeba/efeitos dos fármacos
Amebicidas/farmacologia
Desinfetantes/farmacologia
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amebicides); 0 (Disinfectants)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171224
[St] Status:MEDLINE
[do] DOI:10.17420/ap6303.102


  2 / 2022 MEDLINE  
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[PMID]:29317241
[Au] Autor:Wojtkowiak-Giera A; Derda M; Kosik-Bogacka D; Kolasa-Wolosiuk A; Solarczyk P; Cholewinski M; Wandurska-Nowak E; Jagodzinski PP; Hadas E
[Ad] Endereço:Department of Biology and Medical Parasitology, Poznan University of Medical Sciences, 10 Fredry Street, 61-701 Poznan, Poland.
[Ti] Título:Influence of Artemisia annua L. on toll-like receptor expression in brain of mice infected with Acanthamoeba sp.
[So] Source:Exp Parasitol;185:17-22, 2018 Feb.
[Is] ISSN:1090-2449
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The treatment of acanthamoebiasis is a still a problem. Our previous studies showed that the application of extracts from Artemisia annua L. significantly prolonged the survival of mice infected by Acanthamoeba. This plant has medicinal properties in the treatment of human parasitic diseases. The aim of this study was to evaluate the effects of A. annua on expression of Toll-like receptors (TLRs) 2 and 4 in brain of mice with Acanthamoeba infection. Mice were infected with Acanthamoeba sp. strain Ac309 (KY203908) by intranasal inoculation without and after application of A. annua extract. The administration of extract from A. annua significantly reduced the level of expression of TLR2 and modified the level of expression of TLR4. A. annua extract is a natural substance that is well tolerated in animals and may be considered as a combination therapy in treatment of acanthamoebiasis. Our study suggested that A. annua extract may be used as an alternative therapeutic tool.
[Mh] Termos MeSH primário: Acanthamoeba/efeitos dos fármacos
Amebíase/tratamento farmacológico
Artemisia annua/química
Encéfalo/metabolismo
Fitoterapia
Receptores Toll-Like/efeitos dos fármacos
[Mh] Termos MeSH secundário: Amebíase/metabolismo
Animais
Encéfalo/patologia
Expressão Gênica
Imuno-Histoquímica
Camundongos
Camundongos Endogâmicos BALB C
Extratos Vegetais/farmacologia
Extratos Vegetais/uso terapêutico
RNA Mensageiro/metabolismo
Reação em Cadeia da Polimerase em Tempo Real
Receptor 2 Toll-Like/efeitos dos fármacos
Receptor 2 Toll-Like/genética
Receptor 2 Toll-Like/metabolismo
Receptor 4 Toll-Like/efeitos dos fármacos
Receptor 4 Toll-Like/genética
Receptor 4 Toll-Like/metabolismo
Receptores Toll-Like/genética
Receptores Toll-Like/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (RNA, Messenger); 0 (Tlr2 protein, mouse); 0 (Tlr4 protein, mouse); 0 (Toll-Like Receptor 2); 0 (Toll-Like Receptor 4); 0 (Toll-Like Receptors)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE


  3 / 2022 MEDLINE  
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[PMID]:29211242
[Au] Autor:Castro-Artavia E; Retana-Moreira L; Lorenzo-Morales J; Abrahams-Sandí E
[Ad] Endereço:University of Costa Rica, Faculty of Microbiology, Department of Parasitology, San Pedro, San José, Costa Rica.
[Ti] Título:Potentially pathogenic Acanthamoeba genotype T4 isolated from dental units and emergency combination showers.
[So] Source:Mem Inst Oswaldo Cruz;112(12):817-821, 2017 Dec.
[Is] ISSN:1678-8060
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Acanthamoeba is the genus of free-living amoebae that is most frequently isolated in nature. To date, 20 Acanthamoeba genotypes have been described. Genotype T4 is responsible for approximately 90% of encephalitis and keratitis cases. Due to the ubiquitous presence of amoebae, isolation from environmental sources is not uncommon; to determine the clinical importance of an isolation, it is necessary to have evidence of the pathogenic potential of amoebae. OBJECTIVE: The aim of this study was to physiologically characterise 8 Acanthamoeba T4 isolates obtained from dental units and emergency combination showers and to determine their pathogenic potential by employing different laboratory techniques. METHODS: Eight axenic cultures of Acanthamoeba genotype T4 were used in pathogenic potential assays. Osmotolerance, thermotolerance, determination and characterisation of extracellular proteases and evaluation of cytopathic effects in MDCK cells were performed. FINDINGS: All of the isolates were osmotolerant, thermotolerant and had serine proteases from 44-122 kDa. Two isolates had cytopathic effects on the MDCK cell monolayer. MAIN CONCLUSION: The presence of Acanthamoeba T4 with pathogenic potential in areas such as those tested in this study reaffirms the need for adequate cleaning and maintenance protocols to reduce the possibility of infection with free-living amoebae.
[Mh] Termos MeSH primário: Acanthamoeba
Microbiologia Ambiental
[Mh] Termos MeSH secundário: Acanthamoeba/genética
Acanthamoeba/isolamento & purificação
Acanthamoeba/patogenicidade
Genótipo
Seres Humanos
Filogenia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171227
[Lr] Data última revisão:
171227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


  4 / 2022 MEDLINE  
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[PMID]:28452995
[Au] Autor:Tan SZ; Walkden A; Au L; Fullwood C; Hamilton A; Qamruddin A; Armstrong M; Brahma AK; Carley F
[Ad] Endereço:Centre for Ophthalmology and Vision Sciences, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK.
[Ti] Título:Twelve-year analysis of microbial keratitis trends at a UK tertiary hospital.
[So] Source:Eye (Lond);31(8):1229-1236, 2017 Aug.
[Is] ISSN:1476-5454
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PurposeTo investigate the frequencies, trends, and in vitro drug susceptibilities of the causative pathogens in microbial keratitis in Manchester Royal Eye Hospital.Patients and methodsCorneal scrape results recorded by the microbiology service between 2004 and 2015 were extracted from an established database. A total of 4229 corneal scrape specimens were identified from an established database. First-line antibiotic treatment in our centre during the study period was ofloxacin and second line was cefuroxime and gentamicin.ResultsMean age was 45.9±21.0. A total of 1379 samples (32.6%) were culture positive. One hundred forty-eight (10.7%) specimens cultured multiple organisms. Of the 1539 organisms identified, 63.3% were Gram-positive bacteria, 27.3% Gram-negative bacteria, 7.1% fungi, and 2.3% Acanthamoebae. A decreasing trend in Gram-positive isolates was found together with a stable trend in Gram negatives and an increasing trend in Acanthamoeba and fungi. There appeared to be a significant increasing trend of Moraxella infection (P=0.001). In all, 83.1 and 90.8% of Gram-positive and -negative isolates tested were susceptible to ofloxacin, respectively. Cefuroxime covered 86.6% of Gram-positive and 61.4% of Gram-negative isolates, whereas gentamicin covered 88.8 and 96.5% of Gram-positive and -negative isolates, respectively.ConclusionWe found a change in the type of Gram-negative organisms isolated over time, with the Moraxella species on the rise. Reassuringly, no significant increase in resistance was observed in vitro for any of the commonly used antibiotics. Ofloxacin remains a good first-line antibiotic treatment but duo-therapy does have broader coverage and should be considered in non-responsive cases.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Infecções Oculares Bacterianas/microbiologia
Ceratite/microbiologia
[Mh] Termos MeSH secundário: Acanthamoeba/isolamento & purificação
Adulto
Idoso
Antibacterianos/farmacologia
Úlcera da Córnea/microbiologia
Farmacorresistência Bacteriana/efeitos dos fármacos
Infecções Oculares Bacterianas/tratamento farmacológico
Feminino
Fungos/isolamento & purificação
Bactérias Gram-Negativas/efeitos dos fármacos
Bactérias Gram-Negativas/isolamento & purificação
Bactérias Gram-Positivas/efeitos dos fármacos
Bactérias Gram-Positivas/isolamento & purificação
Seres Humanos
Ceratite/tratamento farmacológico
Masculino
Testes de Sensibilidade Microbiana
Meia-Idade
Estudos Retrospectivos
Centros de Atenção Terciária/estatística & dados numéricos
Reino Unido
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171221
[Lr] Data última revisão:
171221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1038/eye.2017.55


  5 / 2022 MEDLINE  
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[PMID]:28763516
[Au] Autor:Kwon E; Pathak D; Chang HW; Kim DY
[Ad] Endereço:College of Pharmacy, Yeungnam University, Gyeongsan, Gyeongbuk, South Korea.
[Ti] Título:Crystal structure of mimivirus uracil-DNA glycosylase.
[So] Source:PLoS One;12(8):e0182382, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cytosine deamination induced by stresses or enzymatic catalysis converts deoxycytidine into deoxyuridine, thereby introducing a G to A mutation after DNA replication. Base-excision repair to correct uracil to cytosine is initiated by uracil-DNA glycosylase (UDG), which recognizes and eliminates uracil from DNA. Mimivirus, one of the largest known viruses, also encodes a distinctive UDG gene containing a long N-terminal domain (N-domain; residues 1-130) and a motif-I (residues 327-343), in addition to the canonical catalytic domain of family I UDGs (also called UNGs). To understand the structural and functional features of the additional segments, we have determined the crystal structure of UNG from Acanthamoeba polyphaga mimivirus (mvUNG). In the crystal structure of mvUNG, residues 95-130 in the N-domain bind to a hydrophobic groove in the catalytic domain, and motif-I forms a short ß-sheet with a positively charged surface near the active site. Circular dichroism spectra showed that residues 1-94 are in a random coil conformation. Deletion of the three additional fragments reduced the activity and thermal stability, compared to full-length mvUNG. The results suggested that the mvUNG N-domain and motif-I are required for its structural and functional integrity.
[Mh] Termos MeSH primário: Mimiviridae/enzimologia
Uracila-DNA Glicosidase/química
[Mh] Termos MeSH secundário: Acanthamoeba/virologia
Motivos de Aminoácidos
Domínio Catalítico
Dicroísmo Circular
Cristalografia por Raios X
DNA/química
Reparo do DNA
Deleção de Genes
Mimiviridae/genética
N-Glicosil Hidrolases/química
Estrutura Secundária de Proteína
Coloração pela Prata
Especificidade por Substrato
Uracila/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
56HH86ZVCT (Uracil); 9007-49-2 (DNA); EC 3.2.2.- (N-Glycosyl Hydrolases); EC 3.2.2.- (Uracil-DNA Glycosidase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170802
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182382


  6 / 2022 MEDLINE  
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[PMID]:28656012
[Au] Autor:Neelam S; Niederkorn JY
[Ad] Endereço:Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX.
[Ti] Título:Pathobiology and Immunobiology of Keratitis: Insights from Animal Models
.
[So] Source:Yale J Biol Med;90(2):261-268, 2017 Jun.
[Is] ISSN:1551-4056
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:keratitis (AK) is a rare but sight-threatening disease caused by pathogenic species of . Despite its ubiquitous nature, the incidence of AK is relatively low compared to other forms of infectious keratitis. Although contact lens wear is a major risk factor, exposure to contaminated water and ocular trauma are also associated with AK. Once a patient develops AK the prognosis is very poor unless an aggressive treatment regimen is initiated early. Some of the intriguing features of AK are the lack of immunological memory, resistance of the dormant cyst form to treatment, differences between the pathogenic strains and soil isolates of and the unique role of the innate immune system in controlling this disease. Understanding the series of steps involved in the pathogenesis of the disease and the host immune response against antigens is crucial for developing effective therapeutic strategies targeting the disease.
[Mh] Termos MeSH primário: Ceratite por Acanthamoeba/patologia
[Mh] Termos MeSH secundário: Acanthamoeba/imunologia
Ceratite por Acanthamoeba/etiologia
Ceratite por Acanthamoeba/imunologia
Imunidade Adaptativa
Animais
Proteínas do Sistema Complemento/fisiologia
Córnea/parasitologia
Córnea/patologia
Modelos Animais de Doenças
Seres Humanos
Imunidade Inata
Imunidade nas Mucosas
Fatores de Risco
Receptores Toll-Like/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Toll-Like Receptors); 9007-36-7 (Complement System Proteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170629
[St] Status:MEDLINE


  7 / 2022 MEDLINE  
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[PMID]:28609649
[Au] Autor:Dobrowsky PH; Khan S; Khan W
[Ad] Endereço:Department of Microbiology, Faculty of Science, Stellenbosch University, Private Bag X1, Stellenbosch 7602, South Africa. Electronic address: pstevens@sun.ac.za.
[Ti] Título:Resistance of Legionella and Acanthamoeba mauritaniensis to heat treatment as determined by relative and quantitative polymerase chain reactions.
[So] Source:Environ Res;158:82-93, 2017 10.
[Is] ISSN:1096-0953
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Legionella and Acanthamoeba spp. persist in harvested rainwater pasteurized at high temperatures (> 72°C) and the interaction mechanisms exhibited between these organisms need to be elucidated. The resistance of two Legionella reference strains (Legionella pneumophila ATCC 33152 and Legionella longbeachae ATCC 33462), three environmental strains [Legionella longbeachae (env.), Legionella norrlandica (env.) and Legionella rowbothamii (env.)] and Acanthamoeba mauritaniensis ATCC 50676 to heat treatment (50-90°C) was determined by monitoring culturability and viability [ethidium monoazide quantitative polymerase chain reaction (EMA-qPCR)]. The expression of metabolic and virulence genes of L. pneumophila ATCC 33152 (lolA, sidF, csrA) and L. longbeachae (env.) (lolA) in co-culture with A. mauritaniensis ATCC 50676 during heat treatment (50-90°C) was monitored using relative qPCR. While the culturability (CFU/mL) and viability (gene copies/mL) of the Legionella strains reduced significantly (p < 0.05) following heat treatment (60-90°C), L. longbeachae (env.) and L. pneumophila ATCC 33152 were culturable following heat treatment at 50-60°C. Metabolically active trophozoites and dormant cysts of A. mauritaniensis ATCC 50676 were detected at 50°C and 60-90°C, respectively. For L. pneumophila ATCC 33152, lolA expression remained constant, sidF expression increased and the expression of csrA decreased during co-culture with A. mauritaniensis ATCC 50676. For L. longbeachae (env.), while lolA was up-regulated at 50-70°C, expression was not detected at 80-90°C and in co-culture. In conclusion, while heat treatment may reduce the number of viable Legionella spp. in monoculture, results indicate that the presence of A. mauritaniensis increases the virulence of L. pneumophila during heat treatment. The virulence of Legionella spp. in co-culture with Acanthamoeba spp. should thus be monitored in water distribution systems where temperature (heat) is utilized for treatment.
[Mh] Termos MeSH primário: Acanthamoeba/fisiologia
Temperatura Alta
Legionella/fisiologia
[Mh] Termos MeSH secundário: Acanthamoeba/genética
Acanthamoeba/microbiologia
Legionella/genética
Reação em Cadeia da Polimerase em Tempo Real
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171120
[Lr] Data última revisão:
171120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170614
[St] Status:MEDLINE


  8 / 2022 MEDLINE  
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[PMID]:28591260
[Au] Autor:Yousuf FA; Siddiqui R; Khan NA
[Ad] Endereço:Aga Khan University, Department of Biological and Biomedical Sciences, Karachi, Pakistan.
[Ti] Título:Presence of rotavirus and free-living amoebae in the water supplies of Karachi, Pakistan.
[So] Source:Rev Inst Med Trop Sao Paulo;59:e32, 2017 Jun 01.
[Is] ISSN:1678-9946
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Rotavirus and pathogenic free-living amoebae are causative agents of important health problems, especially for developing countries like Pakistan where the population has limited access to clean water supplies. Here, we evaluated the prevalence of rotavirus and free-living amoebae (Acanthamoeba spp., Balamuthia mandrillaris, Naegleria fowleri) in drinking water supplies of Karachi, Pakistan. Six water filtration plants that supply drinking water to the population of Karachi were investigated. Additionally, drinking water samples from households were analyzed for the presence of rotavirus and free-living amoebae. Rotavirus was present in 35% of the water samples collected from water filtration plants; however, domestic tap water samples had a prevalence of only 5%. Out of 20 water samples from filtration plants, 13 (65%) were positive for Acanthamoeba spp., and one (5%) was positive for B. mandrillaris. Out of 20 drinking water samples collected from different areas of Karachi, 35% were positive for Acanthamoeba spp. Rotavirus was detected in 5% of the drinking water samples tested. Overall, these findings showed for the first time the presence of rotavirus, in addition to pathogenic free-living amoebae in drinking water supplies of Karachi that could be an important public health risk for the affected population.
[Mh] Termos MeSH primário: Acanthamoeba/isolamento & purificação
Balamuthia mandrillaris/isolamento & purificação
Naegleria/isolamento & purificação
Rotavirus/isolamento & purificação
Microbiologia da Água
Abastecimento de Água
Água/parasitologia
[Mh] Termos MeSH secundário: Seres Humanos
Paquistão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
059QF0KO0R (Water)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170705
[Lr] Data última revisão:
170705
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE


  9 / 2022 MEDLINE  
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[PMID]:28472161
[Au] Autor:Huth S; Reverey JF; Leippe M; Selhuber-Unkel C
[Ad] Endereço:Institute of Materials Science, Biocompatible Nanomaterials, Christian-Albrechts-Universität zu Kiel, Kaiserstr. 2, D-24143 Kiel, Germany.
[Ti] Título:Adhesion forces and mechanics in mannose-mediated acanthamoeba interactions.
[So] Source:PLoS One;12(5):e0176207, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The human pathogenic amoeba Acanthamoeba castellanii (A. castellanii) causes severe diseases, including acanthamoeba keratitis and encephalitis. Pathogenicity arises from the killing of target-cells by an extracellular killing mechanism, where the crucial first step is the formation of a close contact between A. castellanii and the target-cell. This process is mediated by the glycocalix of the target-cell and mannose has been identified as key mediator. The aim of the present study was to carry out a detailed biophysical investigation of mannose-mediated adhesion of A. castellanii using force spectroscopy on single trophozoites. In detail, we studied the interaction of a mannose-coated cantilever with an A. castellanii trophozoite, as mannose is the decisive part of the cellular glycocalix in mediating pathogenicity. We observed a clear increase of the force to initiate cantilever detachment from the trophozoite with increasing contact time. This increase is also associated with an increase in the work of detachment. Furthermore, we also analyzed single rupture events during the detachment process and found that single rupture processes are associated with membrane tether formation, suggesting that the cytoskeleton is not involved in mannose binding events during the first few seconds of contact. Our study provides an experimental and conceptual basis for measuring interactions between pathogens and target-cells at different levels of complexity and as a function of interaction time, thus leading to new insights into the biophysical mechanisms of parasite pathogenicity.
[Mh] Termos MeSH primário: Acanthamoeba/metabolismo
Aderência Bacteriana
Manose/metabolismo
[Mh] Termos MeSH secundário: Microscopia de Força Atômica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
PHA4727WTP (Mannose)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0176207


  10 / 2022 MEDLINE  
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[PMID]:28329521
[Au] Autor:Winsett F; Dietert J; Tschen J; Swaby M; Bangert CA
[Ad] Endereço:University of Texas, Houston, School of Medicine, Houston, Texas. frank.t.winsett@uth.tmc.edu.
[Ti] Título:A rare case of cutaneous acanthamoebiasis in a renal transplant patient.
[So] Source:Dermatol Online J;23(3), 2017 Mar 15.
[Is] ISSN:1087-2108
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A 35-year-old woman receiving immunosuppressionfor renal transplantation presented with a onemonthhistory of tender skin nodules on herbilateral upper extremities. A skin biopsy revealedgranulomatous inflammation in the deep dermisand the subcutaneous fat with foci of necrosis.Within the foci of necrosis were large histiocytoidstructures with prominent nuclei. Periodic acid-Schiffstain revealed a round organism with a thick capsule,consistent with amoebal trophozoites. Testing withthe Center for Disease Control revealed the organismto be Acanthamoeba. Despite antimicrobial therapy,the patient continued to develop subcutaneousnodules that extended to the lower extremities andtrunk and ultimately extended to the bone, causingacanthamoebal osteomyelitis. Throughout thehospital course, the patient remained neurologicallyintact without evidence of central nervousinvolvement. A diagnosis of isolated disseminatedcutaneous acanthamoebiasis secondary to iatrogenicimmunosuppression was made. Historically, mostcases of granulomatous amoebic encephalitisand cutaneous acanthamoebiasis have occurredin patients with HIV/AIDS. However, with the useof newer and more effective immunosuppressiveregimens, both are occurring more frequently inthe setting of iatrogenic immunosuppression. Therare and isolated cutaneous nature of this patient'spresentation makes this case unique.
[Mh] Termos MeSH primário: Acanthamoeba
Amebíase/diagnóstico
Rejeição de Enxerto/prevenção & controle
Imunossupressores/efeitos adversos
Transplante de Rim
Dermatopatias Parasitárias/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Amebíase/etiologia
Amebíase/patologia
Braço
Dorso
Feminino
Seres Humanos
Dermatopatias Parasitárias/etiologia
Dermatopatias Parasitárias/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunosuppressive Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE



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