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  1 / 14205 MEDLINE  
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[PMID]:29320825
[Au] Autor:Kim HJ; Yong TS; Shin MH; Lee KJ; Park GM; Suvonkulov U; Kovalenko D; Yu HS
[Ad] Endereço:Department of Parasitology and Tropical Medicine, School of Medicine, Pusan National University, Yangsan 50612, Korea.
[Ti] Título:Practical Algorisms for PCR-RFLP-Based Genotyping of Echinococcus granulosus Sensu Lato.
[So] Source:Korean J Parasitol;55(6):679-684, 2017 Dec.
[Is] ISSN:1738-0006
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:Echinococcus granulosus sensu lato (s.l.) is a causative agent of cystic echinococcosis or cystic hydatid disease in humans and domestic and wild animals. The disease is a serious health problem in countries associated with poverty and poor hygiene practices, particularly in livestock raising. We introduced a practical algorism for genotyping the parasite, which may be useful to many developing countries. To evaluate the efficiency of the algorism, we genotyped 3 unknown strains isolated from human patients. We found that unknowns 1 and 3 were included in G1, G2, and G3 genotypes group and unknown 2 was included in G4 genotype (Echinococcus equinus) according to the algorisms. We confirmed these results by sequencing the 3 unknown isolates cox1 and nad1 PCR products. In conclusion, these new algorisms are very fast genotype identification tools that are suitable for evaluating E. granulosus s.l. isolated from livestock or livestock holders, particularly in developing countries.
[Mh] Termos MeSH primário: Algoritmos
Equinococose/parasitologia
Equinococose/veterinária
Echinococcus granulosus/genética
Genótipo
Técnicas de Genotipagem/métodos
Reação em Cadeia da Polimerase
Polimorfismo de Fragmento de Restrição
[Mh] Termos MeSH secundário: Animais
Animais Domésticos
Ciclo-Oxigenase 1/genética
Echinococcus granulosus/isolamento & purificação
Complexo I de Transporte de Elétrons/genética
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 1.14.99.1 (Cyclooxygenase 1); EC 1.6.5.3 (Electron Transport Complex I)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.3347/kjp.2017.55.6.679


  2 / 14205 MEDLINE  
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[PMID]:29320824
[Au] Autor:Hou H; Cao L; Ren W; Wang D; Ding H; You J; Yao X; Dong H; Guo Y; Yuan S; Zhang X; Gong P
[Ad] Endereço:Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, 130062, China.
[Ti] Título:Seroprevalence of Dirofilaria immitis in Cats from Liaoning Province, Northeastern China.
[So] Source:Korean J Parasitol;55(6):673-677, 2017 Dec.
[Is] ISSN:1738-0006
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:The present study was performed to investigate the seroprevalence and risk factors for Dirofilaria immitis infection in cats from Liaoning province, northeastern China. From October 2014 to September 2016, sera of 651 cats, including 364 domestic cats and 287 feral cats (332 females and 319 males) were assessed. They were tested for the presence of D. immitis antigen using SNAP Heartworm RT test kit. In this population, the average prevalence was 4.5%. Age and rearing conditions (feral or domestic) were found to be associated with the prevalence of D. immitis. The prevalence was significantly higher in feral cats compared with domestic cats (8.4% vs 1.4%, P<0.01). There was no significant difference between males and females (4.7% vs 4.2%, P>0.05), but older cats (≥3 years old) showed a statistically higher prevalence compared with younger cats (<3 years old) in feral populations (16.8 vs 2.4%, P<0.01), while the difference between the age groups was not statistically significant in domestic cats (2.4% vs 0.51%, P>0.05), all these results suggest that outdoor exposure time may be one of the most important factors for D. immitis prevalence in cats. Results reveal that D. immitis are prevalence in domestic and feral cats in northeastern China, which indicates that appropriate preventive measures should be taken to decrease the incidence of feline heartworm disease in Liaoning province, northeastern China.
[Mh] Termos MeSH primário: Doenças do Gato/epidemiologia
Doenças do Gato/parasitologia
Dirofilaria immitis
Dirofilariose/epidemiologia
Dirofilariose/parasitologia
[Mh] Termos MeSH secundário: Fatores Etários
Criação de Animais Domésticos
Animais
Animais Domésticos
Antígenos de Helmintos/sangue
Biomarcadores/sangue
Doenças do Gato/prevenção & controle
Gatos
China/epidemiologia
Dirofilaria immitis/imunologia
Dirofilariose/prevenção & controle
Feminino
Masculino
Prevalência
Fatores de Risco
Estudos Soroepidemiológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Helminth); 0 (Biomarkers)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.3347/kjp.2017.55.6.673


  3 / 14205 MEDLINE  
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[PMID]:29254921
[Au] Autor:Tan C; Bian C; Yang D; Li N; Wu ZF; Hu XX
[Ad] Endereço:1. State Key Laboratory of Agricultural Biotechnology, China Agricultural University, Beijing 100193, China; 2. National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China; 3. Guangdong Wens Foodstuff Group
[Ti] Título:Application of genomic selection in farm animal breeding.
[So] Source:Yi Chuan;39(11):1033-1045, 2017 Nov 20.
[Is] ISSN:0253-9772
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:Genomic selection (GS) has become a widely accepted method in animal breeding to genetically improve economic traits. With the declining costs of high-density SNP chips and next-generation sequencing, GS has been applied in dairy cattle, swine, poultry and other animals and gained varying degrees of success. Currently, major challenges in GS studies include further reducing the cost of genome-wide SNP genotyping and improving the predictive accuracy of genomic estimated breeding value (GEBV). In this review, we summarize various methods for genome-wide SNP genotyping and GEBV prediction, and give a brief introduction of GS in livestock and poultry breeding. This review will provide a reference for further implementation of GS in farm animal breeding.
[Mh] Termos MeSH primário: Animais Domésticos/genética
Cruzamento
Seleção Genética
[Mh] Termos MeSH secundário: Animais
Teorema de Bayes
Bovinos/genética
Técnicas de Genotipagem
Sequenciamento de Nucleotídeos em Larga Escala
Polimorfismo de Nucleotídeo Único
Aves Domésticas/genética
Suínos/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE
[do] DOI:10.16288/j.yczz.17-286


  4 / 14205 MEDLINE  
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[PMID]:29335818
[Au] Autor:Ohrnberger SA; Brinkmann K; Palme R; Valencak TG
[Ad] Endereço:Institute of Physiology, Pathophysiology and Biophysics, Department of Biomedical Sciences, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210, Vienna, Austria. sarah.ohrnberger@vetmeduni.ac.at.
[Ti] Título:Dorsal shaving affects concentrations of faecal cortisol metabolites in lactating golden hamsters.
[So] Source:Naturwissenschaften;105(1-2):13, 2018 Jan 15.
[Is] ISSN:1432-1904
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Breeding of golden hamsters is classically performed at thermal conditions ranging from 20 to 24 °C. However, growing evidence suggests that lactating females suffer from heat stress. We hypothesised that shaving females dorsally to maximise heat dissipation may reduce stress during reproduction. We thus compared faecal cortisol metabolites (FCM) from shaved golden hamster mothers with those from unshaved controls. We observed significantly lower FCM levels in the shaved mothers (F = 8.69, p = 0.0075) pointing to lower stress due to ameliorated heat dissipation over the body surface. In addition, we observed 0.4 °C lower mean subcutaneous body temperatures in the shaved females, although this effect did not reach significance (F = 1.86, p = 0.18). Our results suggest that golden hamsters having body masses being more than four times that of laboratory mice provide a very interesting model to study aspects of lactation and heat production at the same time.
[Mh] Termos MeSH primário: Regulação da Temperatura Corporal
Cricetinae/fisiologia
[Mh] Termos MeSH secundário: Animais
Animais Domésticos
Temperatura Corporal/fisiologia
Fezes/química
Feminino
Remoção de Cabelo/veterinária
Hidrocortisona/metabolismo
Lactação
Reprodução/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180117
[St] Status:MEDLINE
[do] DOI:10.1007/s00114-017-1536-7


  5 / 14205 MEDLINE  
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[PMID]:29357367
[Au] Autor:Mujibi FD; Okoth E; Cheruiyot EK; Onzere C; Bishop RP; Fèvre EM; Thomas L; Masembe C; Plastow G; Rothschild M
[Ad] Endereço:Nelson Mandela Africa Institution of Science and Technology, Arusha, Tanzania.
[Ti] Título:Genetic diversity, breed composition and admixture of Kenyan domestic pigs.
[So] Source:PLoS One;13(1):e0190080, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The genetic diversity of African pigs, whether domestic or wild has not been widely studied and there is very limited published information available. Available data suggests that African domestic pigs originate from different domestication centers as opposed to international commercial breeds. We evaluated two domestic pig populations in Western Kenya, in order to characterize the genetic diversity, breed composition and admixture of the pigs in an area known to be endemic for African swine fever (ASF). One of the reasons for characterizing these specific populations is the fact that a proportion of indigenous pigs have tested ASF virus (ASFv) positive but do not present with clinical symptoms of disease indicating some form of tolerance to infection. Pigs were genotyped using either the porcine SNP60 or SNP80 chip. Village pigs were sourced from Busia and Homabay counties in Kenya. Because bush pigs (Potamochoerus larvatus) and warthogs (Phacochoerus spp.) are known to be tolerant to ASFv infection (exhibiting no clinical symptoms despite infection), they were included in the study to assess whether domestic pigs have similar genomic signatures. Additionally, samples representing European wild boar and international commercial breeds were included as references, given their potential contribution to the genetic make-up of the target domestic populations. The data indicate that village pigs in Busia are a non-homogenous admixed population with significant introgression of genes from international commercial breeds. Pigs from Homabay by contrast, represent a homogenous population with a "local indigenous' composition that is distinct from the international breeds, and clusters more closely with the European wild boar than African wild pigs. Interestingly, village pigs from Busia that tested negative by PCR for ASFv genotype IX, had significantly higher local ancestry (>54%) compared to those testing positive, which contained more commercial breed gene introgression. This may have implication for breed selection and utilization in ASF endemic areas. A genome wide scan detected several regions under preferential selection with signatures for pigs from Busia and Homabay being very distinct. Additionally, there was no similarity in specific genes under selection between the wild pigs and domestic pigs despite having some broad areas under similar selection signatures. These results provide a basis to explore possible genetic determinants underlying tolerance to infection by ASFv genotypes and suggests multiple pathways for genetically mediated ASFv tolerance given the diversity of selection signatures observed among the populations studied.
[Mh] Termos MeSH primário: Animais Domésticos/genética
Variação Genética
Suínos/genética
[Mh] Termos MeSH secundário: Animais
Quênia
Polimorfismo de Nucleotídeo Único
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180123
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190080


  6 / 14205 MEDLINE  
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[PMID]:29281717
[Au] Autor:Al-Araimi NA; Gaafar OM; Costa V; Neira AL; Al-Atiyat RM; Beja-Pereira A
[Ad] Endereço:Research Center in Biodiversity and Genetic Resources (CIBIO), University of Porto, Vairão, Porto, Portugal.
[Ti] Título:Genetic origin of goat populations in Oman revealed by mitochondrial DNA analysis.
[So] Source:PLoS One;12(12):e0190235, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Sultanate of Oman has a complex mosaic of livestock species and production systems, but the genetic diversity, demographic history or origins of these Omani animals has not been expensively studied. Goats might constitute one of the most abundant and important domestic livestock species since the Neolithic transition. Here, we examined the genetic diversity, origin, population structure and demographic history of Omani goats. Specifically, we analyzed a 525-bp fragment of the first hypervariable region of the mitochondrial DNA (mtDNA) control region from 69 Omani individuals and compared this fragment with 17 mtDNA sequences from Somalia and Yemen as well as 18 wild goat species and 1,198 previously published goat sequences from neighboring countries. The studied goat breeds show substantial diversity. The haplotype and nucleotide diversities of Omani goats were found equal to 0.983 ± 0.006 and 0.0284 ± 0.014, respectively. The phylogenetic analyses allowed us to classify Omani goats into three mtDNA haplogroups (A, B and G): haplogroup A was found to be predominant and widely distributed and accounted for 80% of all samples, and haplogroups B and G exhibited low frequencies. Phylogenetic comparisons with wild goats revealed that five of the native Omani goat populations originate from Capra aegagrus. Furthermore, most comparisons of pairwise population FST values within and between these five Omani goat breeds as well as between Omani goats and nine populations from nearby countries were not significant. These results suggest strong gene flow among goat populations caused by the extensive transport of goats and the frequent movements of human populations in ancient Arabia. The findings improve our understanding of the migration routes of modern goats from their region of domestication into southeastern Arabia and thereby shed light on human migratory and commercial networks during historical times.
[Mh] Termos MeSH primário: DNA Mitocondrial/genética
Cabras/genética
[Mh] Termos MeSH secundário: Animais
Animais Domésticos/genética
Variação Genética
Omã
Filogenia
Reação em Cadeia da Polimerase
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Mitochondrial)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171228
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190235


  7 / 14205 MEDLINE  
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[PMID]:29247662
[Au] Autor:Ferrari ED; Nakamura AA; Nardi ARM; Santana BN; da Silva Camargo V; Nagata WB; Bresciani KDS; Meireles MV
[Ad] Endereço:Universidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária, Araçatuba, Brazil - Clóvis Pestana St., 793 - Dona Amélia, 16050-680, Araçatuba, SP, Brazil. Electronic address: elisd.ferrari@yahoo.com.br.
[Ti] Título:Cryptosporidium spp. in caged exotic psittacines from Brazil: Evaluation of diagnostic methods and molecular characterization.
[So] Source:Exp Parasitol;184:109-114, 2018 Jan.
[Is] ISSN:1090-2449
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to evaluate the prevalence of and diagnostic methods for Cryptosporidium spp. in caged adult exotic parrots from Southern and Southeastern Brazil. Oocysts were purified from fecal samples from 463 psittacines by centrifugal-flotation in Sheather's sugar solution. Cryptosporidium spp. were detected by malachite green negative staining and nested PCR targeting the 18S rRNA gene. Cryptosporidium species were identified by sequencing nested PCR amplicons. Samples were also tested by duplex real-time PCR targeting the 18S rRNA gene of Cryptosporidium galli and Cryptosporidium avian genotype III. The prevalence rates of Cryptosporidium spp. determined by microscopy and nested PCR were 3.0% (14/463) and 5.0% (23/463), respectively. The nested PCR/sequencing identified avian genotype III (1.7%; 8/463), Cryptosporidium parvum (0.9%; 4/463) and Cryptosporidium canis (0.2%; 1/463). Duplex real-time PCR was positive for gastric Cryptosporidium in 9.5% (44/463) of the samples. Among them, 1.9% (9/463) were positive for C. galli, 5.8% (27/463) were positive for avian genotype III and 1.7% (8/463) showed mixed infections with C. galli and avian genotype III. With regards to the positive detection of Cryptosporidium spp., there was no statistically significant difference between nested PCR and microscopic analysis (p = .1237), and a fair agreement existed between them (Kappa = 0.242). A statistically significant difference (p < .0001) and fair agreement (Kappa = 0.317) were obtained between nested PCR/sequencing and duplex real-time PCR for the detection of gastric Cryptosporidium. We determined that nested PCR and duplex real-time PCR are the best options for the detection of Cryptosporidium spp. and gastric Cryptosporidium, respectively, and that avian genotype III is the most common Cryptosporidium genotype/species in psittacines.
[Mh] Termos MeSH primário: Doenças das Aves/diagnóstico
Criptosporidiose/diagnóstico
Cryptosporidium/isolamento & purificação
Papagaios/parasitologia
[Mh] Termos MeSH secundário: Animais
Animais Domésticos
Doenças das Aves/epidemiologia
Doenças das Aves/parasitologia
Brasil/epidemiologia
Clonagem Molecular
Criptosporidiose/epidemiologia
Criptosporidiose/parasitologia
Cryptosporidium/classificação
Cryptosporidium/genética
DNA de Protozoário/química
Fezes/parasitologia
Reação em Cadeia da Polimerase/veterinária
Prevalência
RNA Ribossômico 18S/genética
Reação em Cadeia da Polimerase em Tempo Real/veterinária
Análise de Sequência de DNA/veterinária
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Protozoan); 0 (RNA, Ribosomal, 18S)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE


  8 / 14205 MEDLINE  
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[PMID]:29211731
[Au] Autor:Watson CH; Coriakula J; Ngoc DTT; Flasche S; Kucharski AJ; Lau CL; Thieu NTV; le Polain de Waroux O; Rawalai K; Van TT; Taufa M; Baker S; Nilles EJ; Kama M; Edmunds WJ
[Ad] Endereço:Centre for the Mathematical Modelling of Infectious Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.
[Ti] Título:Social mixing in Fiji: Who-eats-with-whom contact patterns and the implications of age and ethnic heterogeneity for disease dynamics in the Pacific Islands.
[So] Source:PLoS One;12(12):e0186911, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Empirical data on contact patterns can inform dynamic models of infectious disease transmission. Such information has not been widely reported from Pacific islands, nor strongly multi-ethnic settings, and few attempts have been made to quantify contact patterns relevant for the spread of gastrointestinal infections. As part of enteric fever investigations, we conducted a cross-sectional survey of the general public in Fiji, finding that within the 9,650 mealtime contacts reported by 1,814 participants, there was strong like-with-like mixing by age and ethnicity, with higher contact rates amongst iTaukei than non-iTaukei Fijians. Extra-domiciliary lunchtime contacts follow these mixing patterns, indicating the overall data do not simply reflect household structures. Inter-ethnic mixing was most common amongst school-age children. Serological responses indicative of recent Salmonella Typhi infection were found to be associated, after adjusting for age, with increased contact rates between meal-sharing iTaukei, with no association observed for other contact groups. Animal ownership and travel within the geographical division were common. These are novel data that identify ethnicity as an important social mixing variable, and use retrospective mealtime contacts as a socially acceptable metric of relevance to enteric, contact and respiratory diseases that can be collected in a single visit to participants. Application of these data to other island settings will enable communicable disease models to incorporate locally relevant mixing patterns in parameterisation.
[Mh] Termos MeSH primário: Fatores Etários
Ingestão de Alimentos
Grupos Étnicos
Infecções por Salmonella/transmissão
Comportamento Social
[Mh] Termos MeSH secundário: Animais
Animais Domésticos
Busca de Comunicante
Fiji
Seres Humanos
Propriedade
Ilhas do Pacífico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180110
[Lr] Data última revisão:
180110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186911


  9 / 14205 MEDLINE  
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[PMID]:29284246
[Au] Autor:Vasylieva N; Andreychyn M; Kravchuk Y; Chervinska О; Iosyk I
[Ad] Endereço:Department of Infectious Diseases and Epidemiology, I. Ya. Horbachevsky State Medical University, Ternopil, Ukraine. Vasylyeva@tdmu.edu.ua.
[Ti] Título:Changes in leptospirosis etiology in animals and humans.
[So] Source:Ann Agric Environ Med;24(4):671-675, 2017 Dec 23.
[Is] ISSN:1898-2263
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Leptospirosis is endemic in Ternopil region. In Ukraine, the disease is registered in almost all regions, including the Ternopil region. The aim of the research is to study the regularities of epidemic and epizootic processes of leptospirosis, and the circulation of its pathogens among different sources (small mammals, animals) and humans. MATERIAL AND METHODS: Etiologic spectrum of leptospirosis registered in Ternopil region in 1972-2016 among small mammals, farm animals and sick people was studied. RESULTS: Due to the analysis of pathogens circulation among different sources (small mammals, animals), as well as the annual morbidity in humans, it was proved that new leptospira serovars are endemic and brought into the regions mostly by farm animals. Farm animals introduce the infection to humans through the environment, sometimes within 3-5-years. The spread was observed of pathogen serovars, which are new in certain areas, among all types of mouse-like small mammals and rats. It was established that livestock and small mammals are parallel reservoirs. CONCLUSIONS: In the regions with endemic species, the structural modification in the etiology of leptospirosis in humans is caused by additional reservoirs among animals, as well as the circulation of other pathogen serovars that were absent in the main natural reservoir, i.e. mouse-like small mammals and rats. The constant monitoring of the population, contamination and carrier state of mouse-like small mammals, rats and farm animals, is required In order to predict the future epidemiological situation on leptospirosis among the population and to improve leptospirosis diagnosis.
[Mh] Termos MeSH primário: Leptospira/fisiologia
Leptospirose/microbiologia
Leptospirose/veterinária
Mamíferos/microbiologia
[Mh] Termos MeSH secundário: Animais
Animais Domésticos/microbiologia
Portador Sadio/microbiologia
Reservatórios de Doenças/microbiologia
Seres Humanos
Leptospira/genética
Leptospira/isolamento & purificação
Leptospirose/epidemiologia
Gado/microbiologia
Ucrânia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171230
[St] Status:MEDLINE


  10 / 14205 MEDLINE  
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[PMID]:29240762
[Au] Autor:Bert B; Dörendahl A; Leich N; Vietze J; Steinfath M; Chmielewska J; Hensel A; Grune B; Schönfelder G
[Ad] Endereço:German Federal Institute for Risk Assessment (BfR), German Centre for the Protection of Laboratory Animals (Bf3R), Berlin, Germany.
[Ti] Título:Rethinking 3R strategies: Digging deeper into AnimalTestInfo promotes transparency in in vivo biomedical research.
[So] Source:PLoS Biol;15(12):e2003217, 2017 Dec.
[Is] ISSN:1545-7885
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In the European Union (EU), animal welfare is seen as a matter of great importance. However, with respect to animal experimentation, European citizens feel quite uninformed. The European Directive 2010/63/EU for the protection of laboratory animals aims for greater transparency and requires that a comprehensible, nontechnical summary (NTS) of each authorised research project involving animals is published by the respective Member State. However, the NTSs remain sleeping beauties if their contents are not easily and systematically accessible. The German web-based NTS database AnimalTestInfo is a unique channel for scientists to communicate their work, and provides the opportunity for large-scale analyses of planned animal studies to inform researchers and the public. For an in-depth meta-analysis, we classified the duly completed NTSs submitted to AnimalTestInfo in 2014 and 2015 according to the International Classification of Diseases and Related Health Problems (ICD) system. Indexing the NTSs with ICD codes provided a fine-grained overview of the prospective uses of experimental animals. Using this approach, transparency, especially for highly controversial animal research involving, for example, nonhuman primates, is fostered, as it enables pinpointing the envisaged beneficiary down to the level of the addressed disease. Moreover, research areas with many planned projects involving animals can be specified in detail. The development of 3R (replacement, reduction, and refinement) measures in these research areas may be most efficient, as a large number of experimental animals would benefit from it. Indexing NTSs with ICD codes can support governments and funding agencies in advancing target-oriented funding of 3R research. Data drawn from NTSs can provide a basis for the development, validation, and implementation of directed 3R strategies as well as guidance for rethinking the role of animal research models.
[Mh] Termos MeSH primário: Experimentação Animal
Bem-Estar do Animal
Pesquisa Biomédica
Projetos de Pesquisa/legislação & jurisprudência
Projetos de Pesquisa/normas
[Mh] Termos MeSH secundário: Experimentação Animal/ética
Experimentação Animal/legislação & jurisprudência
Experimentação Animal/normas
Experimentação Animal/estatística & dados numéricos
Bem-Estar do Animal/ética
Bem-Estar do Animal/legislação & jurisprudência
Bem-Estar do Animal/normas
Bem-Estar do Animal/estatística & dados numéricos
Animais
Animais Domésticos
Animais de Laboratório
Animais Selvagens
Bioética
Pesquisa Biomédica/ética
Pesquisa Biomédica/legislação & jurisprudência
Pesquisa Biomédica/normas
Pesquisa Biomédica/estatística & dados numéricos
Alemanha/epidemiologia
Seres Humanos
Estudos Prospectivos
Projetos de Pesquisa/estatística & dados numéricos
Pesquisadores/ética
Pesquisadores/legislação & jurisprudência
Pesquisadores/normas
Pesquisadores/estatística & dados numéricos
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pbio.2003217



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