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[PMID]: 28747434 [Au] Autor: Sallon C; Callebaut I; Boulay I; Fontaine J; Logeart-Avramoglou D; Henriquet C; Pugnière M; Cayla X; Monget P; Harichaux G; Labas V; Canepa S; Taragnat C [Ad] Endereço: From the Unité Physiologie de la Reproduction et des Comportements, UMR85, Institut National de la Recherche Agronomique, CNRS, Institut Français du Cheval et de l'Equitation, Université de Tours, F-37380 Nouzilly, France. [Ti] Título: Thrombospondin-1 (TSP-1), a new bone morphogenetic protein-2 and -4 (BMP-2/4) antagonist identified in pituitary cells. [So] Source: J Biol Chem;292(37):15352-15368, 2017 09 15. [Is] ISSN: 1083-351X [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Bone morphogenetic proteins (BMPs) regulate diverse cellular responses during embryogenesis and in adulthood including cell differentiation, proliferation, and death in various tissues. In the adult pituitary, BMPs participate in the control of hormone secretion and cell proliferation, suggesting a potential endocrine/paracrine role for BMPs, but some of the mechanisms are unclear. Here, using a bioactivity test based on embryonic cells (C3H10T1/2) transfected with a BMP-responsive element, we sought to determine whether pituitary cells secrete BMPs or BMP antagonists. Interestingly, we found that pituitary-conditioned medium contains a factor that inhibits action of BMP-2 and -4. Combining surface plasmon resonance and high-resolution mass spectrometry helped pinpoint this factor as thrombospondin-1 (TSP-1). Surface plasmon resonance and co-immunoprecipitation confirmed that recombinant human TSP-1 can bind BMP-2 and -4 and antagonize their effects on C3H10T1/2 cells. Moreover, TSP-1 inhibited the action of serum BMPs. We also report that the von Willebrand type C domain of TSP-1 is likely responsible for this BMP-2/4-binding activity, an assertion based on sequence similarity that TSP-1 shares with the von Willebrand type C domain of Crossveinless 2 (CV-2), a BMP antagonist and member of the chordin family. In summary, we identified for the first time TSP-1 as a BMP-2/-4 antagonist and presented a structural basis for the physical interaction between TSP-1 and BMP-4. We propose that TSP-1 could regulate bioavailability of BMPs, either produced locally or reaching the pituitary via blood circulation. In conclusion, our findings provide new insights into the involvement of TSP-1 in the BMP-2/-4 mechanisms of action. [Mh] Termos MeSH primário: Proteína Morfogenética Óssea 2/antagonistas & inibidores Proteína Morfogenética Óssea 4/antagonistas & inibidores Modelos Moleculares Hipófise/secreção Elementos de Resposta Trombospondina 1/secreção [Mh] Termos MeSH secundário: Animais Animais Endogâmicos Proteína Morfogenética Óssea 2/sangue Proteína Morfogenética Óssea 2/genética Proteína Morfogenética Óssea 2/metabolismo Proteína Morfogenética Óssea 4/sangue Proteína Morfogenética Óssea 4/genética Proteína Morfogenética Óssea 4/metabolismo Linhagem Celular Células Cultivadas Biologia Computacional Feminino Genes Reporter Seres Humanos Camundongos Hipófise/citologia Hipófise/metabolismo Domínios e Motivos de Interação entre Proteínas Proteínas Recombinantes de Fusão/química Proteínas Recombinantes de Fusão/isolamento & purificação Proteínas Recombinantes de Fusão/metabolismo Proteínas Recombinantes/química Proteínas Recombinantes/metabolismo Homologia de Sequência de Aminoácidos Carneiro Doméstico Trombospondina 1/química Trombospondina 1/isolamento & purificação Trombospondina 1/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (BMP2 protein, human); 0 (BMP4 protein, human); 0 (Bone Morphogenetic Protein 2); 0 (Bone Morphogenetic Protein 4); 0 (Recombinant Fusion Proteins); 0 (Recombinant Proteins); 0 (Thrombospondin 1); 0 (thrombospondin-1, human) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 171230 [Lr] Data última revisão: 171230 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170728 [St] Status: MEDLINE [do] DOI: 10.1074/jbc.M116.736207

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[PMID]: 28407177 [Au] Autor: Zhang LC; Liang J; Pu L; Zhang YB; Wang LG; Liu X; Yan H; Wang LX [Ad] Endereço: Key Laboratory of Farm Animal Genetic Resources and Germplasm Innovation, Ministry of Agriculture/Institute of Animal Science, , , China zhlchias@163.com. [Ti] Título: mRNA and protein expression levels of four candidate genes for ear size in Erhualian and Large White pigs. [So] Source: Genet Mol Res;16(2), 2017 Apr 13. [Is] ISSN: 1676-5680 [Cp] País de publicação: Brazil [La] Idioma: eng [Ab] Resumo: Porcine ear size is an important characteristic for distinguishing among pig breeds. In a previous genome-wide association study of porcine ear size, LEM domain-containing 3 (LEMD3), methionine sulfoxide reductase B3 (MSRB3), high mobility group AT-hook 2 (HMGA2), and Wnt inhibitory factor 1 (WIF1) were implicated as important candidate genes for ear size. This study investigated the expression levels of four candidate genes for ear size in Erhualian and Large White pigs. Ten Erhualian pigs with large ears and eight Large White pigs with small ears at 60 days of age were examined. The mRNA expression levels of the four candidate genes were quantified by real-time polymerase chain reaction. WIF1 mRNA expression was significantly higher in Large White than in Erhualian pigs (P < 0.05), whereas the expression levels of the other three genes were not significantly different between the two breeds. The protein expression levels of the four genes were analyzed using western blot. WIF1 protein expression was significantly higher in Large White than in Erhualian pigs (P < 0.01), whereas MSRB3 protein expression was significantly higher in Erhualian than in Large White pigs (P < 0.05). There were no significant differences between the two breeds in residual protein expression. These results suggest that WIF1 is the main causal gene for ear size in pigs. [Mh] Termos MeSH primário: Orelha/crescimento & desenvolvimento Locos de Características Quantitativas Suínos/genética [Mh] Termos MeSH secundário: Animais Animais Endogâmicos Proteínas da Matriz Extracelular/genética Proteínas da Matriz Extracelular/metabolismo Perfilação da Expressão Gênica Estudo de Associação Genômica Ampla Peptídeos e Proteínas de Sinalização Intercelular/genética Peptídeos e Proteínas de Sinalização Intercelular/metabolismo Metionina Sulfóxido Redutases/genética Metionina Sulfóxido Redutases/metabolismo RNA Mensageiro/genética RNA Mensageiro/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Extracellular Matrix Proteins); 0 (Intercellular Signaling Peptides and Proteins); 0 (RNA, Messenger); EC 1.8.4.- (Methionine Sulfoxide Reductases); EC 1.8.4.11 (methionine sulfoxide reductase) [Em] Mês de entrada: 1705 [Cu] Atualização por classe: 170504 [Lr] Data última revisão: 170504 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170414 [St] Status: MEDLINE [do] DOI: 10.4238/gmr16029252

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[PMID]: 28214695 [Au] Autor: Bauer A; Ni Y; Bauer S; Paulsen P; Modic M; Walsh JL; Smulders FJ [Ad] Endereço: Institute of Meat Hygiene, Meat Technology and Food Science, Department of Farm Animals and Veterinary Public Health, University of Veterinary Medicine, Vienna, Austria. [Ti] Título: The effects of atmospheric pressure cold plasma treatment on microbiological, physical-chemical and sensory characteristics of vacuum packaged beef loin. [So] Source: Meat Sci;128:77-87, 2017 Jun. [Is] ISSN: 1873-4138 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Effects on vacuum packaged and non-packaged beef longissimus samples exposed to atmospheric cold plasma (ACP) generated at different powers were studied over a 10day period of vacuum-, and a subsequent 3day period of aerobic storage. Exposure of non-covered beef samples under high power ACP conditions resulted in increased a*, b*, Chroma and Hue values, but ACP treatment of packaged loins did not impact colour (L*, a*, b*, Chroma, Hue), lipid peroxidation, sarcoplasmic protein denaturation, nitrate/nitrite uptake, or myoglobin isoform distribution. Colour values measured after 3days of aerobic storage following unpackaging (i.e. 20days post-mortem) were similar and all compliant with consumer acceptability standards. Exposure to ACP of the polyamide-polyethylene packaging film inoculated with Staphylococcus aureus, Listeria monocytogenes and two Escherichia coli strains resulted in >2 log reduction without affecting the integrity of the packaging matrix. Results indicate that ACP can reduce microbial numbers on surfaces of beef packages without affecting characteristics of the packaged beef. [Mh] Termos MeSH primário: Embalagem de Alimentos Conservação de Alimentos Qualidade dos Alimentos Carne/análise [Mh] Termos MeSH secundário: Animais Animais Endogâmicos Pressão Atmosférica Bovinos Escherichia coli/efeitos dos fármacos Escherichia coli/crescimento & desenvolvimento Estudos de Viabilidade Armazenamento de Alimentos Seres Humanos Listeria monocytogenes/efeitos dos fármacos Listeria monocytogenes/crescimento & desenvolvimento Masculino Carne/microbiologia Viabilidade Microbiana/efeitos dos fármacos Fenômenos Físicos Pigmentos Biológicos/análise Pigmentos Biológicos/química Gases em Plasma/química Gases em Plasma/farmacologia Refrigeração Sensação Staphylococcus aureus/efeitos dos fármacos Staphylococcus aureus/crescimento & desenvolvimento Vácuo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Pigments, Biological); 0 (Plasma Gases) [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170713 [Lr] Data última revisão: 170713 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170220 [St] Status: MEDLINE

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[PMID]: 28214693 [Au] Autor: Chiaia HL; Peripoli E; Silva RM; Aboujaoude C; Feitosa FL; Lemos MV; Berton MP; Olivieri BF; Espigolan R; Tonussi RL; Gordo DG; Bresolin T; Magalhães AF; Júnior GA; Albuquerque LG; Oliveira HN; Furlan JJ; Ferrinho AM; Mueller LF; Tonhati H; Pereira AS; Baldi F [Ad] Endereço: Faculdade de Ciências Agrárias e Veterinárias, UNESP, Jaboticabal, SP, 14884-000, Brazil. Electronic address: chiaia1@yahoo.com.br. [Ti] Título: Genomic prediction for beef fatty acid profile in Nellore cattle. [So] Source: Meat Sci;128:60-67, 2017 Jun. [Is] ISSN: 1873-4138 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: The objective of this study was to compare SNP-BLUP, BayesCπ, BayesC and Bayesian Lasso methodologies to predict the direct genomic value for saturated, monounsaturated, and polyunsaturated fatty acid profile, omega 3 and 6 in the Longissimus thoracis muscle of Nellore cattle finished in feedlot. A total of 963 Nellore bulls with phenotype for fatty acid profiles, were genotyped using the Illumina BovineHD BeadChip (Illumina, San Diego, CA) with 777,962 SNP. The predictive ability was evaluated using cross validation. To compare the methodologies, the correlation between DGV and pseudo-phenotypes was calculated. The accuracy varied from -0.40 to 0.62. Our results indicate that none of the methods excelled in terms of accuracy, however, the SNP-BLUP method allows obtaining less biased genomic evaluations, thereby; this method is more feasible when taking into account the analyses' operating cost. Despite the lowest bias observed for EBV, the adjusted phenotype is the preferred pseudophenotype considering the genomic prediction accuracies regarding the context of the present study. [Mh] Termos MeSH primário: Ácidos Graxos/análise Genômica/métodos Carne/análise Modelos Genéticos Proteínas Musculares/genética Músculo Esquelético/metabolismo Polimorfismo de Nucleotídeo Único [Mh] Termos MeSH secundário: Animais Animais Endogâmicos Teorema de Bayes Brasil Bovinos Ácidos Graxos/metabolismo Ácidos Graxos Monoinsaturados/metabolismo Ácidos Graxos Ômega-3/metabolismo Ácidos Graxos Ômega-6/metabolismo Estudos de Viabilidade Seres Humanos Masculino Proteínas Musculares/metabolismo Músculo Esquelético/crescimento & desenvolvimento Valor Nutritivo Seleção Genética [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE; VALIDATION STUDIES [Nm] Nome de substância: 0 (Fatty Acids); 0 (Fatty Acids, Monounsaturated); 0 (Fatty Acids, Omega-3); 0 (Fatty Acids, Omega-6); 0 (Muscle Proteins) [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170713 [Lr] Data última revisão: 170713 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170220 [St] Status: MEDLINE

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[PMID]: 28189991 [Au] Autor: Fidelis HA; Bonilha SF; Tedeschi LO; Branco RH; Cyrillo JN; Mercadante ME [Ad] Endereço: Instituto de Zootecnia, Centro APTA Bovinos de Corte, Sertãozinho, SP 14.160-970, Brazil. [Ti] Título: Residual feed intake, carcass traits and meat quality in Nellore cattle. [So] Source: Meat Sci;128:34-39, 2017 Jun. [Is] ISSN: 1873-4138 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: A total of 127 Nellore bulls classified as low and high residual feed intake (RFI), from three selection lines, were evaluated in five experiments aiming to identify associations between RFI, carcass, and meat quality traits. Feedlot performance, carcass traits, and meat quality of Longissimus muscle were evaluated. A mixed model including the fixed effects of RFI class, selection line, interaction between RFI class and selection line, and age at slaughter as a covariate, and the random effects of diet within experiment and experiment was used, with means compared by the t-test. Feed intake average difference was 0.962kg/day; low RFI animals consumed 0.479kg/day less feed and high RFI animals consumed 0.483kg/day more feed than expected. No differences between RFI classes were detected for most of studied variables, demonstrating the absence of unfavorable associations between RFI and carcass and meat quality traits. Low RFI Nellore animals use feed efficiently and produce good quality carcasses and meat. [Mh] Termos MeSH primário: Ingestão de Energia Qualidade dos Alimentos Carne/análise Modelos Biológicos Músculo Esquelético/crescimento & desenvolvimento [Mh] Termos MeSH secundário: Matadouros Animais Animais Endogâmicos Comportamento Animal Brasil Bovinos Culinária Gorduras na Dieta Armazenamento de Alimentos Concentração de Íons de Hidrogênio Masculino Músculo Esquelético/metabolismo Pigmentos Biológicos/análise Estações do Ano Ganho de Peso [Pt] Tipo de publicação: COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Dietary Fats); 0 (Pigments, Biological) [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170713 [Lr] Data última revisão: 170713 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170213 [St] Status: MEDLINE

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[PMID]: 28163019 [Au] Autor: Sirotkin AV; Florkovicová Konicková I; Schaeffer HJ; Laurincik J; Harrath AH [Ad] Endereço: Dept. Zoology and Anthropology, Constantine the Philosopher University, 949 74 Nitra, Slovakia; Dept. Genetics and Reproduction, Research Institute of Animal Production, 949 59 Luzianky, Slovakia. Electronic address: asirotkin@ukf.sk. [Ti] Título: Interrelationships between ovarian follicles grown in culture and possible mediators. [So] Source: Reprod Biol;17(1):97-104, 2017 Mar. [Is] ISSN: 2300-732X [Cp] País de publicação: Poland [La] Idioma: eng [Ab] Resumo: Dominance or cooperation between ovarian follicles can determine the number of ovulations and fecundity, but interrelationships between follicles in mono- and poly-ovulatory species and their mechanisms are poorly understood. The goals of this work were to determine the existence and compare the character of mutual influence of cultured ovarian follicles from a mono-ovulatory species (cow) with established follicular dominance with those from a poly-ovulatory species (pig), in which interrelationship between follicles remain unknown, and to examine the role of ovarian cell proliferation, the insulin-like growth factor I (IGF-I)- oxytocin (OT) system, and steroid hormones in mediating interrelationships among ovarian follicles. Bovine and porcine ovarian follicles were isolated and cultured alone and in pairs, and the percentage of growing follicles was calculated. Porcine follicles were cultured alone and in pairs after addition of exogenous OT and IGF-I (100ngmL ) or inactivation of endogenous OT and IGF-I by antisera against these hormones (1%). Proliferation of porcine follicular cells was assessed by SDS PAGE-Western immunoblotting, the release of IGF-I, progesterone, androstenedione and estradiol by cultured porcine ovarian follicles was analyzed by RIA/EIA. Overall, our observations suggest (1) competition/dominance (mutual suppression of growth) in bovine ovarian follicles, (2) cooperation (mutual support of growth) in porcine ovarian follicles, (3) that this mutual growth of porcine ovarian follicles was caused by the promotion of cell proliferation, (4) that this mechanism was probably not involved in bovine follicular dominance, (5) that communication between both porcine and bovine follicles affects their secretory activity, and (6) that both follicular dominance in cows and cooperation of follicles in pigs can be mediated by either down- or up-regulation of the IGF-I-OT system, which in turn affects follicular steroidogenesis and promotes follicular cell proliferation and follicular growth. [Mh] Termos MeSH primário: Fator de Crescimento Insulin-Like I/metabolismo Folículo Ovariano/metabolismo Ocitocina/metabolismo [Mh] Termos MeSH secundário: Matadouros Androstenodiona/metabolismo Androstenodiona/secreção Animais Animais Endogâmicos Bovinos Proliferação Celular Estradiol/metabolismo Estradiol/secreção Feminino Fase Folicular Soros Imunes/farmacologia Fator de Crescimento Insulin-Like I/antagonistas & inibidores Fator de Crescimento Insulin-Like I/genética Fator de Crescimento Insulin-Like I/secreção Oogênese Folículo Ovariano/efeitos dos fármacos Folículo Ovariano/crescimento & desenvolvimento Folículo Ovariano/secreção Ocitocina/antagonistas & inibidores Progesterona/metabolismo Progesterona/secreção Proteínas Recombinantes Eslováquia Especificidade da Espécie Sus scrofa Técnicas de Cultura de Tecidos [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Immune Sera); 0 (Recombinant Proteins); 409J2J96VR (Androstenedione); 4G7DS2Q64Y (Progesterone); 4TI98Z838E (Estradiol); 50-56-6 (Oxytocin); 67763-96-6 (Insulin-Like Growth Factor I) [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170719 [Lr] Data última revisão: 170719 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170207 [St] Status: MEDLINE

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[PMID]: 28160663 [Au] Autor: de Prados M; Garcia-Perez JV; Benedito J [Ad] Endereço: ASPA Group, Department of Food Technology, Universitat Politècnica de València, Camí de Vera s/n, E-46022 València, Spain. [Ti] Título: Non-invasive ultrasonic technology for continuous monitoring of pork loin and ham dry salting. [So] Source: Meat Sci;128:8-14, 2017 Jun. [Is] ISSN: 1873-4138 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Online ultrasound measurements were taken using pulse-echo mode in loins (Longissimus dorsi) and hams at different salting times (up to 30days). From the time-domain ultrasonic wave, the time of flight (TOF) was computed as well as its variation between two signals (ΔTOF). A progressive decrease in TOF during dry salting was found, which was linked to the salt gain, water loss and the reduction in sample thickness. Predictive models based on the ultrasonic parameters (ΔTOF and initial time of flight, TOF ) correctly classified 85% of the loins and 90% of the hams into 3 groups of salt content (low/medium/high). The results obtained confirm that the use of the ultrasonic pulse-echo technique is of great potential in the non-destructive monitoring of dry salting in pork loins and hams, as well as in the prediction of the salt gain for classification purposes. [Mh] Termos MeSH primário: Inspeção de Alimentos/métodos Qualidade dos Alimentos Alimentos em Conserva/análise Carne/análise Modelos Biológicos Ultrassom [Mh] Termos MeSH secundário: Animais Animais Endogâmicos Gorduras na Dieta/análise Estudos de Viabilidade Inspeção de Alimentos/instrumentação Conservantes de Alimentos/análise Aprendizado de Máquina Carne/economia Controle de Qualidade Cloreto de Sódio na Dieta/análise Espanha Fatores de Tempo Água/análise [Pt] Tipo de publicação: JOURNAL ARTICLE; VALIDATION STUDIES [Nm] Nome de substância: 0 (Dietary Fats); 0 (Food Preservatives); 0 (Sodium Chloride, Dietary); 059QF0KO0R (Water) [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170713 [Lr] Data última revisão: 170713 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170205 [St] Status: MEDLINE

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[PMID]: 28091915 [Au] Autor: Aleksandrin VV; Kubatiev AA [Ad] Endereço: Research Institute of Pathology and Pathophysiology, Moscow, Russia. aleksandrin-54@mail.ru. [Ti] Título: Wavelet Analysis of Cerebral Microcirculation in Hypovolemic Shock. [So] Source: Bull Exp Biol Med;162(3):406-408, 2017 Jan. [Is] ISSN: 1573-8221 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Hypovolemic shock leads to severe cerebral ischemia and increases spectral amplitudes of cerebral blood flow oscillations in respiratory frequency range. [Mh] Termos MeSH primário: Isquemia Encefálica/diagnóstico Hemorragia Cerebral/diagnóstico Fluxometria por Laser-Doppler/estatística & dados numéricos Choque/diagnóstico Análise de Ondaletas [Mh] Termos MeSH secundário: Animais Animais Endogâmicos Velocidade do Fluxo Sanguíneo Pressão Sanguínea Isquemia Encefálica/fisiopatologia Hemorragia Cerebral/fisiopatologia Circulação Cerebrovascular Masculino Microcirculação Ratos Choque/fisiopatologia Técnicas Estereotáxicas [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1702 [Cu] Atualização por classe: 170208 [Lr] Data última revisão: 170208 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170117 [St] Status: MEDLINE [do] DOI: 10.1007/s10517-017-3626-0

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[PMID]: 27917542 [Au] Autor: Jónás D; Ducrocq V; Fritz S; Baur A; Sanchez MP; Croiseau P [Ad] Endereço: GABI, INRA, AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France. [Ti] Título: Genomic evaluation of regional dairy cattle breeds in single-breed and multibreed contexts. [So] Source: J Anim Breed Genet;134(1):3-13, 2017 Feb. [Is] ISSN: 1439-0388 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: An important prerequisite for high prediction accuracy in genomic prediction is the availability of a large training population, which allows accurate marker effect estimation. This requirement is not fulfilled in case of regional breeds with a limited number of breeding animals. We assessed the efficiency of the current French routine genomic evaluation procedure in four regional breeds (Abondance, Tarentaise, French Simmental and Vosgienne) as well as the potential benefits when the training populations consisting of males and females of these breeds are merged to form a multibreed training population. Genomic evaluation was 5-11% more accurate than a pedigree-based BLUP in three of the four breeds, while the numerically smallest breed showed a < 1% increase in accuracy. Multibreed genomic evaluation was beneficial for two breeds (Abondance and French Simmental) with maximum gains of 5 and 8% in correlation coefficients between yield deviations and genomic estimated breeding values, when compared to the single-breed genomic evaluation results. Inflation of genomic evaluation of young candidates was also reduced. Our results indicate that genomic selection can be effective in regional breeds as well. Here, we provide empirical evidence proving that genetic distance between breeds is only one of the factors affecting the efficiency of multibreed genomic evaluation. [Mh] Termos MeSH primário: Bovinos/classificação Bovinos/genética Linhagem [Mh] Termos MeSH secundário: Animais Animais Endogâmicos Feminino Haplótipos Masculino Locos de Características Quantitativas Reprodução [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1702 [Cu] Atualização por classe: 170213 [Lr] Data última revisão: 170213 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161206 [St] Status: MEDLINE [do] DOI: 10.1111/jbg.12249

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[PMID]: 27793614 [Au] Autor: Tamang AM; Kalra B; Parkash R [Ad] Endereço: Department of Genetics, M. D. University, Rohtak 124001, India. [Ti] Título: Cold and desiccation stress induced changes in the accumulation and utilization of proline and trehalose in seasonal populations of Drosophila immigrans. [So] Source: Comp Biochem Physiol A Mol Integr Physiol;203:304-313, 2017 Jan. [Is] ISSN: 1531-4332 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Changes in the levels of energy metabolites can limit survival ability of Drosophila species under stressful conditions but this aspect has received less attention in wild populations collected in different seasons. We tested cold or desiccation triggered changes in the accumulation or utilization of two energy metabolites (trehalose and proline) in Drosophila immigrans flies reared under season specific environmental conditions. Such D.immigrans populations were subjected to different durations of cold (0°C) or desiccation stress (5% RH) or dual stress. We found stress induced effects of cold vs desiccation on the levels of trehalose as well as for proline. Different durations of cold stress led to accumulation of trehalose while desiccation stress durations revealed utilization of trehalose. In contrast, there was accumulation of proline under desiccation and utilization of proline with cold stress. Since accumulation levels were higher than utilization of each energy metabolite, the effects of dual stress showed additive effect. However, there was no utilization of total body lipids under cold or desiccation stress. We observed significant season specific differences in the amount of energy metabolites but the rate of metabolism did not vary across seasons. Stress triggered changes in trehalose and proline suggest possible link between desiccation and cold tolerance. Finally, stress specific (cold or desiccation) compensatory changes in the levels of trehalose and proline suggest possible energetic homeostasis in D.immigrans living under harsh climatic conditions of montane localities. [Mh] Termos MeSH primário: Aclimatação Drosophila/fisiologia Metabolismo Energético Prolina/metabolismo Estresse Fisiológico Trealose/metabolismo [Mh] Termos MeSH secundário: Alostase Altitude Animais Animais Endogâmicos Animais Selvagens Temperatura Baixa/efeitos adversos Dessecação Drosophila/crescimento & desenvolvimento Feminino Índia Masculino Estações do Ano [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Nm] Nome de substância: 9DLQ4CIU6V (Proline); B8WCK70T7I (Trehalose) [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170726 [Lr] Data última revisão: 170726 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161107 [St] Status: MEDLINE

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