Base de dados : MEDLINE
Pesquisa : B01.050.150.200.199 [Categoria DeCS]
Referências encontradas : 4 [refinar]
Mostrando: 1 .. 4   no formato [Detalhado]

página 1 de 1

  1 / 4 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:27412606
[Au] Autor:Yue JX; Kozmikova I; Ono H; Nossa CW; Kozmik Z; Putnam NH; Yu JK; Holland LZ
[Ad] Endereço:Biosciences at Rice, Rice University, Houston, Texas Present address: Institute for Research on Cancer and Aging, Nice (IRCAN), CNRS UMR 7284, INSERM U1081, Nice 06107 France.
[Ti] Título:Conserved Noncoding Elements in the Most Distant Genera of Cephalochordates: The Goldilocks Principle.
[So] Source:Genome Biol Evol;8(8):2387-405, 2016 Aug 25.
[Is] ISSN:1759-6653
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Cephalochordates, the sister group of vertebrates + tunicates, are evolving particularly slowly. Therefore, genome comparisons between two congeners of Branchiostoma revealed so many conserved noncoding elements (CNEs), that it was not clear how many are functional regulatory elements. To more effectively identify CNEs with potential regulatory functions, we compared noncoding sequences of genomes of the most phylogenetically distant cephalochordate genera, Asymmetron and Branchiostoma, which diverged approximately 120-160 million years ago. We found 113,070 noncoding elements conserved between the two species, amounting to 3.3% of the genome. The genomic distribution, target gene ontology, and enriched motifs of these CNEs all suggest that many of them are probably cis-regulatory elements. More than 90% of previously verified amphioxus regulatory elements were re-captured in this study. A search of the cephalochordate CNEs around 50 developmental genes in several vertebrate genomes revealed eight CNEs conserved between cephalochordates and vertebrates, indicating sequence conservation over >500 million years of divergence. The function of five CNEs was tested in reporter assays in zebrafish, and one was also tested in amphioxus. All five CNEs proved to be tissue-specific enhancers. Taken together, these findings indicate that even though Branchiostoma and Asymmetron are distantly related, as they are evolving slowly, comparisons between them are likely optimal for identifying most of their tissue-specific cis-regulatory elements laying the foundation for functional characterizations and a better understanding of the evolution of developmental regulation in cephalochordates.
[Mh] Termos MeSH primário: Cefalocordados/genética
Sequência Conservada/genética
Evolução Molecular
Sequências Reguladoras de Ácido Nucleico/genética
[Mh] Termos MeSH secundário: Animais
Cordados/genética
Genoma
Anfioxos/genética
Especificidade de Órgãos/genética
Filogenia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170614
[Lr] Data última revisão:
170614
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160715
[St] Status:MEDLINE
[do] DOI:10.1093/gbe/evw158


  2 / 4 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:25841489
[Au] Autor:On JS; Duan C; Chow BK; Lee LT
[Ad] Endereço:School of Biological Sciences, The University of Hong Kong, Hong Kong, China.
[Ti] Título:Functional Pairing of Class B1 Ligand-GPCR in Cephalochordate Provides Evidence of the Origin of PTH and PACAP/Glucagon Receptor Family.
[So] Source:Mol Biol Evol;32(8):2048-59, 2015 Aug.
[Is] ISSN:1537-1719
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Several hypotheses have been proposed regarding the origin and evolution of the secretin family of peptides and receptors. However, identification of homologous ligand-receptor pairs in invertebrates and vertebrates is difficult because of the low levels of sequence identity between orthologs of distant species. In this study, five receptors structurally related to the vertebrate class B1 G protein-coupled receptor (GPCR) family were characterized from amphioxus (Branchiostoma floridae). Phylogenetic analysis showed that they clustered with vertebrate parathyroid hormone receptors (PTHR) and pituitary adenylate cyclase-activating polypeptide (PACAP)/glucagon receptors. These PTHR-like receptors shared synteny with several PTH and PACAP/glucagon receptors identified in spotted gar, Xenopus, and human, indicating that amphioxus preserves the ancestral chordate genomic organization of these receptor subfamilies. According to recent data by Mirabeau and Joly, amphioxus also expresses putative peptide ligands including homologs of PTH (bfPTH1 and 2) and PACAP/GLUC-like peptides (bfPACAP/GLUCs) that may interact with these receptors. Functional analyses showed that bfPTH1 and bfPTH2 activated one of the amphioxus receptors (bf98C) whereas bfPACAP/GLUCs strongly interacted with bf95. In summary, our data confirm the presence of PTH and PACAP/GLUC ligand-receptor pairs in amphioxus, demonstrating that functional homologs of vertebrate PTH and PACAP/glucagon GPCR subfamilies arose before the cephalochordate divergence from the ancestor of tunicates and vertebrates.
[Mh] Termos MeSH primário: Cefalocordados/genética
Evolução Molecular
Glucagon/genética
Hormônio Paratireóideo/genética
Polipeptídeo Hipofisário Ativador de Adenilato Ciclase/genética
Receptor Tipo 1 de Hormônio Paratireóideo/genética
[Mh] Termos MeSH secundário: Animais
Cefalocordados/metabolismo
Glucagon/metabolismo
Seres Humanos
Anfioxos
Hormônio Paratireóideo/metabolismo
Polipeptídeo Hipofisário Ativador de Adenilato Ciclase/metabolismo
Receptor Tipo 1 de Hormônio Paratireóideo/metabolismo
Xenopus
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Parathyroid Hormone); 0 (Pituitary Adenylate Cyclase-Activating Polypeptide); 0 (Receptor, Parathyroid Hormone, Type 1); 9007-92-5 (Glucagon)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150406
[St] Status:MEDLINE
[do] DOI:10.1093/molbev/msv087


  3 / 4 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:25774519
[Au] Autor:Lecroisey C; Le Pétillon Y; Escriva H; Lammert E; Laudet V
[Ad] Endereço:Molecular Zoology Team, Institut de Génomique Fonctionnelle de Lyon, École Normale Supérieure de Lyon, CNRS, Université Lyon, Lyon, France.
[Ti] Título:Identification, evolution and expression of an insulin-like peptide in the cephalochordate Branchiostoma lanceolatum.
[So] Source:PLoS One;10(3):e0119461, 2015.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Insulin is one of the most studied proteins since it is central to the regulation of carbohydrate and fat metabolism in vertebrates and its expression and release are disturbed in diabetes, the most frequent human metabolic disease worldwide. However, the evolution of the function of the insulin protein family is still unclear. In this study, we present a phylogenetic and developmental analysis of the Insulin Like Peptide (ILP) in the cephalochordate amphioxus. We identified an ILP in the European amphioxus Branchiostoma lanceolatum that displays structural characteristics of both vertebrate insulin and Insulin-like Growth Factors (IGFs). Our phylogenetic analysis revealed that amphioxus ILP represents the sister group of both vertebrate insulin and IGF proteins. We also characterized both temporal and spatial expression of ILP in amphioxus. We show that ilp is highly expressed in endoderm and paraxial mesoderm during development, and mainly expressed in the gut of both the developing embryo and adult. We hypothesize that ILP has critical implications in both developmental processes and metabolism and could display IGF- and insulin-like functions in amphioxus supporting the idea of a common ancestral protein.
[Mh] Termos MeSH primário: Cefalocordados/metabolismo
Insulina/isolamento & purificação
Peptídeos/isolamento & purificação
Somatomedinas/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Cefalocordados/genética
Endoderma/metabolismo
Evolução Molecular
Insulina/genética
Insulina/metabolismo
Mesoderma/metabolismo
Peptídeos/genética
Peptídeos/metabolismo
Filogenia
Somatomedinas/genética
Somatomedinas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Insulin); 0 (Peptides); 0 (Somatomedins)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:150325
[Lr] Data última revisão:
150325
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150317
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0119461


  4 / 4 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:25010382
[Au] Autor:Braasch I; Schartl M
[Ad] Endereço:Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA. Electronic address: ibraasch@uoneuro.uoregon.edu.
[Ti] Título:Evolution of endothelin receptors in vertebrates.
[So] Source:Gen Comp Endocrinol;209:21-34, 2014 Dec 01.
[Is] ISSN:1095-6840
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Endothelin receptors are G protein coupled receptors (GPCRs) of the ß-group of rhodopsin receptors that bind to endothelin ligands, which are 21 amino acid long peptides derived from longer prepro-endothelin precursors. The most basal Ednr-like GPCR is found outside vertebrates in the cephalochordate amphioxus, but endothelin ligands are only present among vertebrates, including the lineages of jawless vertebrates (lampreys and hagfishes), cartilaginous vertebrates (sharks, rays, and chimaeras), and bony vertebrates (ray-finned fishes and lobe-finned vertebrates including tetrapods). A bona fide endothelin system is thus a vertebrate-specific innovation with important roles for regulating the cardiovascular system, renal and pulmonary processes, as well as for the development of the vertebrate-specific neural crest cell population and its derivatives. Expectedly, dysregulation of endothelin receptors and the endothelin system leads to a multitude of human diseases. Despite the importance of different types of endothelin receptors for vertebrate development and physiology, current knowledge on endothelin ligand-receptor interactions, on the expression of endothelin receptors and their ligands, and on the functional roles of the endothelin system for embryonic development and in adult vertebrates is very much biased towards amniote vertebrates. Recent analyses from a variety of vertebrate lineages, however, have shown that the endothelin system in lineages such as teleost fish and lampreys is more diverse and is divergent from the mammalian endothelin system. This diversity is mainly based on differential evolution of numerous endothelin system components among vertebrate lineages generated by two rounds of whole genome duplication (three in teleosts) during vertebrate evolution. Here we review current understanding of the evolutionary history of the endothelin receptor family in vertebrates supplemented with surveys on the endothelin receptor gene complement of newly available genome assemblies from phylogenetically informative taxa. Our assessment further highlights the diversity of the vertebrate endothelin system and calls for detailed functional and pharmacological analyses of the endothelin system beyond tetrapods.
[Mh] Termos MeSH primário: Evolução Molecular
Receptores de Endotelina/genética
Vertebrados/genética
[Mh] Termos MeSH secundário: Adulto
Animais
Cefalocordados/genética
Endotelinas/genética
Endotelinas/metabolismo
Peixes/genética
Seres Humanos
Mamíferos/genética
Filogenia
Receptores de Endotelina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Endothelins); 0 (Receptors, Endothelin)
[Em] Mês de entrada:1505
[Cu] Atualização por classe:141208
[Lr] Data última revisão:
141208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140711
[St] Status:MEDLINE



página 1 de 1
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde