Base de dados : MEDLINE
Pesquisa : B01.050.150.200.727 [Categoria DeCS]
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  1 / 2668 MEDLINE  
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[PMID]:29273953
[Au] Autor:Coutinho MCL; Teixeira VL; Santos CSG
[Ad] Endereço:Department of Marine Biology, Institute of Biology, Federal Fluminense University, Outeiro São João Batista, s/no, P.O. Box 100.644, Niterói, RJ, 24020-150, Brazil. marinacoutinho88@gmail.com.
[Ti] Título:A Review of "Polychaeta" Chemicals and their Possible Ecological Role.
[So] Source:J Chem Ecol;44(1):72-94, 2018 Jan.
[Is] ISSN:1573-1561
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Despite the many publications concerning the isolation of substances and the many reviews of marine natural products, some groups of organisms remain poorly studied, including "Polychaeta". In response, this review covers articles published through December 2016 that address marine natural products produced from polychaetes, with a focus on antipredatory strategies, competitors, fouling, and pathogens. A total of 121 compounds were isolated from 1934 to 2016, which includes halogenated aromatics, proteins, amino acids and Lumazine derivatives most notably-with a defensive function were found in the literature, most frequently in the families Sabellidae, Terebellidae, Glyceridae, and Nereididae. The period of highest discovery of natural products in defensive actions for the group was the 2000s. Polychaetes were addressed in 26 revisions of the total 51 articles analyzed and are less reported than other marine invertebrates such as sponges, cnidarians, mollusks, and tunicates. In sum, the present review provides a basis for future research on the marine chemical ecology of polychaetes.
[Mh] Termos MeSH primário: Organismos Aquáticos/química
Produtos Biológicos/química
[Mh] Termos MeSH secundário: Animais
Organismos Aquáticos/metabolismo
Produtos Biológicos/isolamento & purificação
Cnidários/química
Cnidários/metabolismo
Comportamento Consumatório/fisiologia
Equinodermos/química
Equinodermos/metabolismo
Fenômenos Ecológicos e Ambientais
Moluscos/química
Moluscos/metabolismo
Urocordados/química
Urocordados/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biological Products)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171224
[St] Status:MEDLINE
[do] DOI:10.1007/s10886-017-0915-z


  2 / 2668 MEDLINE  
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[PMID]:25815560
[Au] Autor:Ahmed NS; Jaffar Ali HA
[Ad] Endereço:a Department of Biotechnology , Islamiah College (Autonomous) , Vaniyambadi , Tamil Nadu , India.
[Ti] Título:Numts: an impediment to DNA barcoding of Polyclinids, Tunicata.
[So] Source:Mitochondrial DNA A DNA Mapp Seq Anal;27(5):3395-8, 2016 Sep.
[Is] ISSN:2470-1408
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The mitochondrial cytochrome c oxidase subunit I (COI) gene, a widely accepted molecular marker for species identification and classification, has been questioned because of the presence of Numts. In this study we found the presence of Numts in the COI chromatogram of two tunicates, Polyclinum indicum and Polyclinum madrasensis belonging to the genus Polyclinum. Numts were also present in our sequence (Accession Number: KJ944391) and in other sequences belonging to genus Polyclinum in the GenBank record. The GeneBank database of genus Polyclinum contains COI-like sequences and COI pseudogenes, but no record of COI gene from Polyclinids. The prevalence of Numts in Polyclinids belonging to Tunicata, is an impediment to DNA barcoding studies of Polyclinum species.
[Mh] Termos MeSH primário: Código de Barras de DNA Taxonômico/normas
Pseudogenes
Urocordados/genética
[Mh] Termos MeSH secundário: Animais
Complexo IV da Cadeia de Transporte de Elétrons/genética
Filogenia
Urocordados/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 1.9.3.1 (Electron Transport Complex IV)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150328
[St] Status:MEDLINE
[do] DOI:10.3109/19401736.2015.1018238


  3 / 2668 MEDLINE  
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[PMID]:28935526
[Au] Autor:Akahoshi T; Hotta K; Oka K
[Ad] Endereço:Department of Bioscience and Informatics, Faculty of Science and Technology, Keio University, Yokohama 223-8522, Japan.
[Ti] Título:Characterization of calcium transients during early embryogenesis in ascidians Ciona robusta (Ciona intestinalis type A) and Ciona savignyi.
[So] Source:Dev Biol;431(2):205-214, 2017 11 15.
[Is] ISSN:1095-564X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The calcium ion (Ca ) is an important second messenger, and a rapid increase in Ca level (Ca transient) is involved in various aspects of embryogenesis. Although Ca transients play an important role in early developmental stages, little is known about their dynamics throughout embryogenesis. Here, Ca transients were characterized by visualizing Ca dynamics in developing chordate embryos using a fluorescent protein-based Ca indicator, GCaMP6s in combination with finely tuned microscopy. Ca transients were detected in precursors of muscle cells in the late gastrula stage. In the neurula stage, repetitive Ca transients were observed in left and right neurogenic cells, including visceral ganglion (VG) precursors, and the duration of Ca transients was 39±4s. In the early tailbud stage, Ca transients were observed in differentiating precursors of nerve cord neurons. A small population of VG precursors showed rhythmical Ca transients with a duration of 22±4s, suggesting a central pattern generator (CPG) origin. At the mid tailbud stage, Ca transients were observed in a wide area of epidermal cells and named CTECs. The number and frequency of CTECs increased drastically in late tailbud stages, and the timing of the increase coincided with that of the relaxation of the tail bending. The experiment using Ca chelator showed that the CTECs were largely depending on the extracellular Ca . The waveform analysis of Ca transients revealed different features according to duration and frequency. The comprehensive characterization of Ca transients during early ascidian embryogenesis will help our understanding of the role of Ca signaling in chordate embryogenesis.
[Mh] Termos MeSH primário: Sinalização do Cálcio
Embrião não Mamífero/metabolismo
Desenvolvimento Embrionário
Urocordados/embriologia
Urocordados/metabolismo
[Mh] Termos MeSH secundário: Animais
Ciona intestinalis/embriologia
Ciona intestinalis/metabolismo
Gástrula/embriologia
Gástrula/metabolismo
Cauda/embriologia
Imagem com Lapso de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171111
[Lr] Data última revisão:
171111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170923
[St] Status:MEDLINE


  4 / 2668 MEDLINE  
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[PMID]:28926608
[Au] Autor:Herbert RJH; Collins K; Mallinson J; Hall AE; Pegg J; Ross K; Clarke L; Clements T
[Ad] Endereço:Bournemouth University, Department of Life and Environmental Sciences, Faculty of Science and Technology, Talbot Campus, Poole, Dorset, United Kingdom.
[Ti] Título:Epibenthic and mobile species colonisation of a geotextile artificial surf reef on the south coast of England.
[So] Source:PLoS One;12(9):e0184100, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:With increasing coastal infrastructure and use of novel materials there is a need to investigate the colonisation of assemblages associated with new structures, how these differ to natural and other artificial habitats and their potential impact on regional biodiversity. The colonisation of Europe's first artificial surf reef (ASR) was investigated at Boscombe on the south coast of England (2009-2014) and compared with assemblages on existing natural and artificial habitats. The ASR consists of geotextile bags filled with sand located 220m offshore on a sandy sea bed at a depth of 0-5m. Successional changes in epibiota were recorded annually on differently orientated surfaces and depths using SCUBA diving and photography. Mobile faunal assemblages were sampled using Baited Remote Underwater Video (BRUV). Distinct stages in colonisation were observed, commencing with bryozoans and green algae which were replaced by red algae, hydroids and ascidians, however there were significant differences in assemblage structure with depth and orientation. The reef is being utilised by migratory, spawning and juvenile life-history stages of fish and invertebrates. The number of non-native species was larger than on natural reefs and other artificial habitats and some occupied a significant proportion of the structure. The accumulation of 180 benthic and mobile taxa, recorded to date, appears to have arisen from a locally rich and mixed pool of native and non-native species. Provided no negative invasive impacts are detected on nearby protected reefs the creation of novel yet diverse habitats may be considered a beneficial outcome.
[Mh] Termos MeSH primário: Recifes de Corais
[Mh] Termos MeSH secundário: Animais
Clorófitas/crescimento & desenvolvimento
Inglaterra
Peixes/crescimento & desenvolvimento
Invertebrados/crescimento & desenvolvimento
Rodófitas/crescimento & desenvolvimento
Têxteis
Urocordados/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170920
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184100


  5 / 2668 MEDLINE  
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[PMID]:28898595
[Au] Autor:Blanchoud S; Zondag L; Lamare MD; Wilson MJ
[Ti] Título:Hematological Analysis of the Ascidian Botrylloides leachii (Savigny, 1816) During Whole-Body Regeneration.
[So] Source:Biol Bull;232(3):143-157, 2017 Jun.
[Is] ISSN:1939-8697
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Whole-body regeneration (WBR)-the formation of an entire adult from only a small fragment of its own tissue-is extremely rare among chordates. Exceptionally, in the colonial ascidian Botrylloides leachii (Savigny, 1816) a fully functional adult is formed from their common vascular system after ablation of all adults from the colony in just 10 d, thanks to their high blastogenetic potential. While previous studies have identified key genetic markers and morphological changes, no study has yet focused on the hematological aspects of regeneration despite the major involvement of the remaining vascular system and the contained hemocytes in this process. To dissect this process, we analyzed colony blood flow patterns using time-lapse microscopy to obtain a quantitative description of the velocity, reversal pattern, and average distance traveled by hemocytes. We also observed that flows present during regeneration are powered by temporally and spatially synchronized contractions of the terminal ampullae. In addition, we revised previous studies of B. leachii hematology as well as asexual development using histological sectioning and compared the role played by hemocytes during WBR. We found that regeneration starts with a rapid healing response characterized by hemocyte aggregation and infiltration of immunocytes, followed by increased activity of hemoblasts, recruitment of macrophage-like cells for clearing the tissues of debris, and their subsequent disappearance from the circulation concomitant with the maturation of a single regenerated adult. Overall, we provide a detailed account of the hematological properties of regenerating B. leachii colonies, providing novel lines of inquiry toward the decipherment of regeneration in chordates.
[Mh] Termos MeSH primário: Regeneração/fisiologia
Urocordados/fisiologia
[Mh] Termos MeSH secundário: Animais
Hemócitos/metabolismo
Urocordados/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170913
[St] Status:MEDLINE
[do] DOI:10.1086/692841


  6 / 2668 MEDLINE  
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[PMID]:28866998
[Au] Autor:Wang D; Wei Y; Cui Q; Li W
[Ad] Endereço:1​Li Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, PR China.
[Ti] Título:Amylibacter cionae sp. nov., isolated from the sea squirt Ciona savignyi.
[So] Source:Int J Syst Evol Microbiol;67(9):3462-3466, 2017 Sep.
[Is] ISSN:1466-5034
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A Gram-stain-negative, non-motile, aerobic and rod-shaped bacterial strain, designated H-12T, was isolated from a sea squirt (Ciona savignyi) collected from Tsingtao Port, Jiaozhou Bay, China, and its taxonomic position was investigated. Strain H-12T grew optimally at 25-30 °C, at pH 7.0-8.0 and in the presence of 3.0-4.0 % (w/v) NaCl. The 16S rRNA gene sequence of strain H-12T exhibited the highest similarity to that of the type strain of Amylibacter marinus (95.3 %). A neighbour-joining phylogenetic tree based on 16S rRNA gene sequences revealed that strain H-12T clustered with the type strain of A. marinus. The predominant ubiquinone in strain H-12T was identified as Q-10. The major fatty acids of strain H-12T were C18 : 1ω7c and C18 : 1ω7c 11-methyl. The major polar lipids detected in strain H-12T were phosphatidylglycerol, phosphatidylcholine, phosphatidylethanolamine, one unidentified aminolipid, two unidentified phospholipids and five unidentified lipids. The DNA G+C content of strain H-12T was 52.7 mol%. On the basis of phylogenetic, chemotaxonomic and phenotypic properties, strain H-12T is considered to represent a novel species within the genus Amylibacter, for which the name Amylibacter cionae sp. nov. is proposed. The type strain is H-12T (=KCTC 52581T=CGMCC 1.15880T).
[Mh] Termos MeSH primário: Filogenia
Rhodobacteraceae/classificação
Urocordados/microbiologia
[Mh] Termos MeSH secundário: Animais
Técnicas de Tipagem Bacteriana
Composição de Bases
China
DNA Bacteriano/genética
Ácidos Graxos/química
Fosfolipídeos/química
RNA Ribossômico 16S/genética
Rhodobacteraceae/genética
Rhodobacteraceae/isolamento & purificação
Análise de Sequência de DNA
Ubiquinona/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (Fatty Acids); 0 (Phospholipids); 0 (RNA, Ribosomal, 16S); 1339-63-5 (Ubiquinone); I7T5V2W47R (Ubiquinone Q2)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170905
[St] Status:MEDLINE
[do] DOI:10.1099/ijsem.0.002140


  7 / 2668 MEDLINE  
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[PMID]:28854260
[Au] Autor:Conley KR; Sutherland KR
[Ad] Endereço:Department of Biology, Oregon Institute of Marine Biology, University of Oregon, Eugene, Oregon, United States of America.
[Ti] Título:Particle shape impacts export and fate in the ocean through interactions with the globally abundant appendicularian Oikopleura dioica.
[So] Source:PLoS One;12(8):e0183105, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Marine microbes exhibit highly varied, often non-spherical shapes that have functional significance for essential processes, including nutrient acquisition and sinking rates. There is a surprising absence of data, however, on how cell shape affects grazing, which is crucial for predicting the fate of oceanic carbon. We used synthetic spherical and prolate spheroid microbeads to isolate the effect of particle length-to-width ratios on grazing and fate in the ocean. Here we show that the shape of microbe-sized particles affects predation by the appendicularian Oikopleura dioica, a globally abundant marine grazer. Using incubation experiments, we demonstrate that shape affects how particles are retained in the house and that the minimum particle diameter is the key variable determining how particles are ingested. High-speed videography revealed the mechanism behind these results: microbe-sized spheroids oriented with the long axis parallel to fluid streamlines, matching the speed and tortuosity of spheres of equivalent width. Our results suggest that the minimum particle diameter determines how elongated prey interact with the feeding-filters of appendicularians, which may help to explain the prevalence of ellipsoidal cells in the ocean, since a cell's increased surface-to-volume ratio does not always increase predation. We provide the first evidence that grazing by appendicularians can cause non-uniform export of different shaped particles, thereby influencing particle fate.
[Mh] Termos MeSH primário: Comportamento Alimentar/fisiologia
Urocordados/fisiologia
[Mh] Termos MeSH secundário: Animais
Fenômenos Biomecânicos
Carbono/química
Microesferas
Tamanho da Partícula
Gravação em Vídeo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
7440-44-0 (Carbon)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183105


  8 / 2668 MEDLINE  
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[PMID]:28708379
[Au] Autor:Wyche TP; Alvarenga RFR; Piotrowski JS; Duster MN; Warrack SR; Cornilescu G; De Wolfe TJ; Hou Y; Braun DR; Ellis GA; Simpkins SW; Nelson J; Myers CL; Steele J; Mori H; Safdar N; Markley JL; Rajski SR; Bugni TS
[Ad] Endereço:Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison , Madison, Wisconsin 53705, United States.
[Ti] Título:Chemical Genomics, Structure Elucidation, and in Vivo Studies of the Marine-Derived Anticlostridial Ecteinamycin.
[So] Source:ACS Chem Biol;12(9):2287-2295, 2017 Sep 15.
[Is] ISSN:1554-8937
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A polyether antibiotic, ecteinamycin (1), was isolated from a marine Actinomadura sp., cultivated from the ascidian Ecteinascidia turbinata. C enrichment, high resolution NMR spectroscopy, and molecular modeling enabled elucidation of the structure of 1, which was validated on the basis of comparisons with its recently reported crystal structure. Importantly, ecteinamycin demonstrated potent activity against the toxigenic strain of Clostridium difficile NAP1/B1/027 (MIC = 59 ng/µL), as well as other toxigenic and nontoxigenic C. difficile isolates both in vitro and in vivo. Additionally, chemical genomics studies using Escherichia coli barcoded deletion mutants led to the identification of sensitive mutants such as trkA and kdpD involved in potassium cation transport and homeostasis supporting a mechanistic proposal that ecteinamycin acts as an ionophore antibiotic. This is the first antibacterial agent whose mechanism of action has been studied using E. coli chemical genomics. On the basis of these data, we propose ecteinamycin as an ionophore antibiotic that causes C. difficile detoxification and cell death via potassium transport dysregulation.
[Mh] Termos MeSH primário: Actinomycetales/química
Antibacterianos/química
Antibacterianos/farmacologia
Clostridium difficile/efeitos dos fármacos
Ionóforos/química
Ionóforos/farmacologia
[Mh] Termos MeSH secundário: Animais
Antibacterianos/isolamento & purificação
Enterocolite Pseudomembranosa/tratamento farmacológico
Enterocolite Pseudomembranosa/microbiologia
Éteres/química
Éteres/isolamento & purificação
Éteres/farmacologia
Seres Humanos
Ionóforos/isolamento & purificação
Urocordados/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Ethers); 0 (Ionophores)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171123
[Lr] Data última revisão:
171123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE
[do] DOI:10.1021/acschembio.7b00388


  9 / 2668 MEDLINE  
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[PMID]:28602953
[Au] Autor:Kishi K; Hayashi M; Onuma TA; Nishida H
[Ad] Endereço:Department of Biological Sciences, Graduate School of Science, Osaka University, 1-1 Machikaneyama-cho, Toyonaka, Osaka 560-0043, Japan. Electronic address: kkishi@nibb.ac.jp.
[Ti] Título:Patterning and morphogenesis of the intricate but stereotyped oikoplastic epidermis of the appendicularian, Oikopleura dioica.
[So] Source:Dev Biol;428(1):245-257, 2017 08 01.
[Is] ISSN:1095-564X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mechanisms for morphogenetic processes that generate complex patterns in a reproducible manner remain elusive. Live imaging provides a powerful tool to record cell behaviors. The appendicularian, Oikopleura dioica, is a planktonic tunicate that has a rapid developmental speed, small number of cells (less than 3500 cells in a juvenile), and a transparent body. The trunk epidermis, called the oikoplastic epithelium (OE), has elaborate cellular arrangements showing a complex pattern to secrete so-called "house" made of extracellular components. The OE is characterized by invariant number, size, and shape of the monolayer epithelial cells. Pattern formation is achieved during 5h of larval development without growth of the body, making this a suitable system for live imaging of a two-dimensional (2D) sheet. First, we subdivided the OE and defined several domains by cellular resolution, and systematically gave names to the constituent cells, since there is no variation among individuals. Time-lapse imaging of the epidermal cells revealed region-specific pattern formation processes. Each identified domain served as a compartment into which distribution of descendant cells of founder cells is restricted. Regulation of orientation, timing, and the number of rounds of cell divisions, but not cell death and migration, was a critical mechanism for determination of final cell arrangement and size. In addition, displacement of epithelial sheet plates was observed in the Eisen domain. Stem-cell-like cell divisions, whereby large mother stem cells generate a chain of small daughter cells, were involved in formation of the Nasse region and ventral sensory organ. These are the first examples of this kind of stem-cell-like cell division in deuterostomes. Furthermore, labeling of the left or right blastomere of the two-cell-stage embryo, which roughly gives rise to the left or right side of the body, respectively, revealed that the boundary of the descendant cells does not match with the midline of the trunk epidermis. Left and right descendants largely invade into the opposite side in an invariant way, suggesting the possibility that specification of the OE cell identities may occur later in development, most probably around hatching, and depending on cell position in the OE epithelial sheet. These detailed descriptions of OE patterning processes provide basic and essential information to analyze further cell behaviors in the generation of elaborate and intricate but stereotyped 2D cellular patterns in this advantageous model system for developmental and cell biological studies in chordates.
[Mh] Termos MeSH primário: Padronização Corporal/fisiologia
Epitélio/embriologia
Urocordados/embriologia
[Mh] Termos MeSH secundário: Animais
Divisão Celular
Linhagem da Célula
Epiderme/citologia
Morfogênese
Urocordados/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171111
[Lr] Data última revisão:
171111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE


  10 / 2668 MEDLINE  
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[PMID]:28574260
[Au] Autor:Issac M; Aknin M; Gauvin-Bialecki A; Pond CD; Barrows LR; Kashman Y; Carmeli S
[Ad] Endereço:School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University , Ramat Aviv Tel-Aviv 69978, Israel.
[Ti] Título:Mollecarbamates, Molleureas, and Molledihydroisoquinolone, o-Carboxyphenethylamide Metabolites of the Ascidian Didemnum molle Collected in Madagascar.
[So] Source:J Nat Prod;80(6):1844-1852, 2017 Jun 23.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The extract of a sample of the tunicate Didemnum molle (MAY13-117) collected in Mayotte afforded eight new metabolites, mollecarbamates A-D (1-4) and molleureas B-E (5-8), along with the two known natural products, N,N'-diphenylethyl urea (10) and molleurea A (11). Another sample of D. molle (MAD11-BA065) collected in Baie des Assassins, Madagascar, afforded molledihydroisoquinolone (9). Mollecarbamates 1-4 are a family of compounds that possess repeating o-carboxyphenethylamide units and a carbamate moiety, while the molleureas 5-8 contain tetra- and penta-repeating carboxyphenethylamide units and a urea bridge in different positions. Molledihydroisoquinolone (9) is a cyclic form of o-carboxyphenethylamide. We propose that these unique natural products are most probably produced by an unprecedented biosynthetic pathway that contains a yet unknown chorismate mutase variant. The structures of the compounds were elucidated by interpretation of the data from 1D and 2D NMR, HRESIMS, and MS/MS analyses of the positive ESIMS experiments. Compounds 1-8 were tested against pathogenic bacteria and in a cytoprotective HIV cell based assay but did not show any significant effects in these assays.
[Mh] Termos MeSH primário: Carbamatos/isolamento & purificação
Isoquinolinas/isolamento & purificação
Ureia/análogos & derivados
Ureia/isolamento & purificação
Urocordados/química
[Mh] Termos MeSH secundário: Animais
Carbamatos/química
Carbamatos/farmacologia
HIV/efeitos dos fármacos
Seres Humanos
Isoquinolinas/química
Isoquinolinas/farmacologia
Madagáscar
Testes de Sensibilidade Microbiana
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Ureia/química
Ureia/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbamates); 0 (Isoquinolines); 8W8T17847W (Urea)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.7b00123



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