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[PMID]:28926819
[Au] Autor:Heerema JL; Helbing CC; Pyle GG
[Ad] Endereço:Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta, Canada T1K 6T5. Electronic address: jody.heerema@gmail.com.
[Ti] Título:Use of electro-olfactography to measure olfactory acuity in the North American bullfrog (Lithobates (Rana) catesbeiana) tadpole.
[So] Source:Ecotoxicol Environ Saf;147:643-647, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Olfaction is an important sense for aquatic organisms because it provides information about their surroundings, including nearby food, mates, and predators. Electro-olfactography (EOG) is an electrophysiological technique that measures the response of olfactory tissue to olfactory stimuli, and responses are indicative of olfactory acuity. Previous studies have used this technique on a variety of species including frogs, salamanders, daphniids and, most extensively, fish. In the present study, we introduce a novel modified EOG method for use on Lithobates (Rana) catesbeiana tadpoles. Responses to a number of olfactory stimuli including amino acids, an algal extract (Spirulina), and taurocholic acid were tested, as measured by EOG. Tadpoles exhibited consistent and reliable responses to L-alanine and Spirulina extract. Tadpoles also exhibited concentration-dependent responses to Spirulina extract. These findings indicate that tadpole EOG is a viable electrophysiology technique that can be used in future research to study olfactory physiology and impairment in tadpoles.
[Mh] Termos MeSH primário: Fenômenos Eletrofisiológicos
Larva/fisiologia
Percepção Olfatória/fisiologia
Olfato/fisiologia
[Mh] Termos MeSH secundário: Alanina/química
Animais
Técnicas Eletroquímicas
Microeletrodos
Rana catesbeiana
Spirulina/química
Ácido Taurocólico/química
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
5E090O0G3Z (Taurocholic Acid); OF5P57N2ZX (Alanine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170920
[St] Status:MEDLINE


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[PMID]:29298350
[Au] Autor:Tatsuta T; Satoh T; Sugawara S; Hara A; Hosono M
[Ad] Endereço:Division of Cell Recognition Study, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Aobaku, Sendai, Japan.
[Ti] Título:Sialic acid-binding lectin from bullfrog eggs inhibits human malignant mesothelioma cell growth in vitro and in vivo.
[So] Source:PLoS One;13(1):e0190653, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Malignant mesothelioma is an aggressive cancer that results from exposure to asbestos. The therapeutic options for this type of cancer are limited; therefore, the development of novel therapeutic agents is urgently required. Sialic acid-binding lectin isolated from Rana catesbeiana oocytes (cSBL) is a novel therapeutic candidate for cancer, which exhibits antitumor activity mediated through RNA degradation. In the present study, we evaluated the effect of cSBL in vitro and in vivo. Xenograft-competent H2452 and MSTO human mesothelioma cell lines were treated with cSBL, and the pathway by which cSBL induces apoptosis was analyzed. In vivo studies were performed using nude mice inoculated with one of the two cell lines, and the effects of cSBL and pemetrexed were monitored simultaneously. Furthermore, the pharmacological interactions between the three agents (pemetrexed, cisplatin and cSBL) were statistically assessed. It was demonstrated that cSBL treatments caused morphological and biochemical apoptotic changes in both cell lines. Caspase cascade analysis revealed that an intrinsic pathway mediated cSBL-induced apoptosis. The administration of cSBL significantly inhibited tumor growth in two xenograft models, without any adverse effects. Furthermore, the combination index and dose reduction index values indicated that the cSBL + pemetrexed combination showed the highest synergism, and thus potential for reducing dosage of each drug, compared with the other combinations, including the existing pemetrexed + cisplatin regimen. cSBL exerted prominent antitumor effects on malignant mesothelioma cells in vitro and in vivo, and showed favorable effects when combined with pemetrexed. These results suggest that cSBL has potential as a novel drug for the treatment of malignant mesothelioma.
[Mh] Termos MeSH primário: Proteínas de Anfíbios/farmacologia
Proliferação Celular/efeitos dos fármacos
Lectinas/farmacologia
Mesotelioma/patologia
Óvulo/química
Ribonucleases/farmacologia
[Mh] Termos MeSH secundário: Proteínas de Anfíbios/isolamento & purificação
Animais
Apoptose/efeitos dos fármacos
Linhagem Celular Tumoral
Sinergismo Farmacológico
Feminino
Seres Humanos
Técnicas In Vitro
Lectinas/isolamento & purificação
Masculino
Camundongos Endogâmicos BALB C
Camundongos Nus
Pemetrexede/administração & dosagem
Rana catesbeiana
Ribonucleases/isolamento & purificação
Perda de Peso/efeitos dos fármacos
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Amphibian Proteins); 0 (Lectins); 04Q9AIZ7NO (Pemetrexed); EC 3.1.- (Ribonucleases); EC 3.1.- (leczyme protein, Rana)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180104
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190653


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[PMID]:28747438
[Au] Autor:Seno K; Hayashi F
[Ad] Endereço:From the Department of Biology, Faculty of Medicine, and.
[Ti] Título:Palmitoylation is a prerequisite for dimerization-dependent raftophilicity of rhodopsin.
[So] Source:J Biol Chem;292(37):15321-15328, 2017 09 15.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The visual photopigment rhodopsin (Rh) is a prototypical G protein-coupled receptor (GPCR) responsible for initiation of the phototransduction cascade in rod photoreceptors. Similar to other GPCRs, Rh can form dimers or even higher oligomers and tends to have a supramolecular organization that is likely important in the dim light response. Rh also exhibits high affinity for lipid rafts ( raftophilicity) upon light-dependent binding with the cognate G protein transducin (G ), suggesting the presence of lipid raft-like domains in the retinal disk membrane and their importance in phototransduction. However, the relationship between Rh oligomerization and lipid rafts in the disk membrane remains to be explored. Given previous findings that G binds to dimeric Rh and that Rh is posttranslationally modified with two highly raftophilic palmitoyl moieties, we hypothesized that Rh becomes raftophilic upon dimerization. Here, using biochemical assays, we found that Rh*-G complexes in the detergent-resistant membrane are partially resistant to cholesterol depletion by methyl-ß-cyclodextrin and that the Rh-to-G stoichiometry in this methyl-ß-cyclodextrin-resistant complex is 2:1. Next, we found that IgG-mediated Rh-Rh cross-linking renders Rh highly raftophilic, supporting the premise that Rh becomes raftophilic upon dimerization. Rh depalmitoylation via reduction of thioester linkages blocked the translocation of IgG-cross-linked Rh to the detergent-resistant membrane, highlighting that the two palmitoyl moieties are important for the dimerization-dependent raftophilicity of Rh. These results indicate that palmitoylated GPCRs such as Rh can acquire raftophilicity upon G protein-stabilized dimerization and thereby organize receptor-cluster rafts by recruiting raftophilic lipids.
[Mh] Termos MeSH primário: Lipoilação
Microdomínios da Membrana/metabolismo
Modelos Moleculares
Processamento de Proteína Pós-Traducional
Rana catesbeiana/fisiologia
Rodopsina/metabolismo
Segmento Externo da Célula Bastonete/metabolismo
[Mh] Termos MeSH secundário: Proteínas de Anfíbios/química
Proteínas de Anfíbios/metabolismo
Animais
Anticorpos Monoclonais/metabolismo
Cisteína/química
Cistina/química
Adaptação à Escuridão
Dimerização
Interações Hidrofóbicas e Hidrofílicas
Cinética
Luz
Lipoilação/efeitos da radiação
Microdomínios da Membrana/química
Microdomínios da Membrana/efeitos da radiação
Oxirredução
Conformação Proteica/efeitos da radiação
Multimerização Proteica/efeitos da radiação
Processamento de Proteína Pós-Traducional/efeitos da radiação
Estabilidade Proteica/efeitos da radiação
Rodopsina/química
Segmento Externo da Célula Bastonete/química
Segmento Externo da Célula Bastonete/efeitos da radiação
Transducina/química
Transducina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Amphibian Proteins); 0 (Antibodies, Monoclonal); 48TCX9A1VT (Cystine); 9009-81-8 (Rhodopsin); EC 3.6.5.1 (Transducin); K848JZ4886 (Cysteine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171230
[Lr] Data última revisão:
171230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M117.804880


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[PMID]:28803676
[Au] Autor:Claytor SC; Subramaniam K; Landrau-Giovannetti N; Chinchar VG; Gray MJ; Miller DL; Mavian C; Salemi M; Wisely S; Waltzek TB
[Ad] Endereço:Department of Wildlife Ecology and Conservation, University of Florida, Gainesville, FL, USA.
[Ti] Título:Ranavirus phylogenomics: Signatures of recombination and inversions among bullfrog ranaculture isolates.
[So] Source:Virology;511:330-343, 2017 Nov.
[Is] ISSN:1096-0341
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ranaviruses are emerging pathogens of fish, amphibians, and reptiles that threaten aquatic animal industries and wildlife worldwide. Our objective was to genetically characterize ranaviruses isolated during separate bullfrog Lithobates catesbeianus die-offs that occurred eight years apart on the same North American farm. The earlier outbreak was due to a highly pathogenic strain of common midwife toad virus (CMTV) previously known only from Europe and China. The later outbreak was due to a chimeric ranavirus that displayed a novel genome arrangement and a DNA backbone typical for Frog virus 3 (FV3) strains except for interspersed fragments acquired through recombination with the CMTV isolated earlier. Both bullfrog ranaviruses are more pathogenic than wild-type FV3 suggesting recombination may have resulted in the increased pathogenicity observed in the ranavirus isolated in the later outbreak. Our study underscores the role international trade in farmed bullfrogs may have played in the global dissemination of highly pathogenic ranaviruses.
[Mh] Termos MeSH primário: Infecções por Vírus de DNA/veterinária
Variação Genética
Ranavirus/classificação
Ranavirus/genética
Recombinação Genética
Inversão de Sequência
[Mh] Termos MeSH secundário: Animais
Infecções por Vírus de DNA/virologia
DNA Viral/química
DNA Viral/genética
América do Norte
Rana catesbeiana/virologia
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Viral)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170815
[St] Status:MEDLINE


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[PMID]:28570892
[Au] Autor:Montalvão MF; de Souza JM; Guimarães ATB; de Menezes IPP; Castro ALDS; Rodrigues ASL; Malafaia G
[Ad] Endereço:Laboratório de Pesquisas Biológicas, Instituto Federal Goiano - Campus Urutaí, GO, Brazil.
[Ti] Título:The genotoxicity and cytotoxicity of tannery effluent in bullfrog (Lithobates catesbeianus).
[So] Source:Chemosphere;183:491-502, 2017 Sep.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Some of the most polluting activities occur in bovine skin processing. Tannery generates effluents containing high concentrations of heavy metals and organic compounds. The phases composing the leather production process generate a large volume of tannery effluents that are often discarded in aquatic environments without any previous treatment. However, the effect these xenobiotics have on adult representatives belonging to the class Amphibia remains unknown. Thus, the aim of the present study is to assess the geno- and cytotoxic effects of tannery effluent on adult male bullfrogs (Lithobates castesbeianus) exposed to it. Accordingly, the animals were divided into the following groups: negative control (tannery effluent-free water), positive control (cyclophosphamide), and effluent (water added with 5% tannery effluent). The animals were euthanized for blood collection, and erythrocyte analyses were conducted after 35 and 90 days of exposure. The micronuclei (MN) frequency and the frequency of other nuclear abnormalities in each of the animals in the experimental groups were assessed in 2000 erythrocytes. According to the present results, the exposure to tannery effluents increased MN frequency as well as other nuclear abnormalities (i.e., lobed nuclei, binucleated cell, kidney-shaped nuclei, notched nuclei, and apoptotic cell) in the erythrocytes of animals in the effluent group and in the positive control group after 35 and 90 exposure days. Thus, the current study corroborated the hypothesis that the tannery effluent has aneugenic and clastogenic potential in adult male bullfrogs (L. castesbeianus). The present study is the first to report such effect.
[Mh] Termos MeSH primário: Eritrócitos/efeitos dos fármacos
Metais Pesados/toxicidade
Micronúcleos com Defeito Cromossômico/induzido quimicamente
Mutagênicos/toxicidade
Curtume
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Dano ao DNA
Relação Dose-Resposta a Droga
Eritroblastos/química
Eritroblastos/efeitos dos fármacos
Eritroblastos/patologia
Eritrócitos/química
Eritrócitos/patologia
Eritrócitos Anormais/química
Eritrócitos Anormais/efeitos dos fármacos
Eritrócitos Anormais/patologia
Resíduos Industriais/análise
Masculino
Metais Pesados/análise
Testes para Micronúcleos
Estrutura Molecular
Mutagênicos/análise
Rana catesbeiana
Fatores de Tempo
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Industrial Waste); 0 (Metals, Heavy); 0 (Mutagens); 0 (Water Pollutants, Chemical)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE


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[PMID]:28562628
[Au] Autor:Borzée A; Kosch TA; Kim M; Jang Y
[Ad] Endereço:Laboratory of Behavioral Ecology and Evolution, School of Biological Sciences, Seoul National University, Seoul, Republic of Korea.
[Ti] Título:Introduced bullfrogs are associated with increased Batrachochytrium dendrobatidis prevalence and reduced occurrence of Korean treefrogs.
[So] Source:PLoS One;12(5):e0177860, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bullfrogs, Lithobates catesbeianus, have been described as major vectors of the amphibian chytrid fungus, Batrachochytrium dendrobatidis (Bd). Bd is widespread throughout the range of amphibians yet varies considerably within and among populations in prevalence and host impact. In our study, the presence of L. catesbeianus is correlated with a 2.5 increase in Bd prevalence in treefrogs, and the endangered Dryophytes suweonensis displays a significantly higher Bd prevalence than the more abundant D. japonicus for the 37 sites surveyed. In addition, the occurrence of L. catesbeianus was significantly correlated with a decrease in presence of D. suweonensis at sites. We could not determine if it is the presence of bullfrogs as competitors or predators that is limiting the distribution of D. suweonensis or whether this is caused by bullfrogs acting as a reservoir for Bd. However, L. catesbeianus can now be added to the list of factors responsible for the decline of D. suweonensis populations.
[Mh] Termos MeSH primário: Anuros/microbiologia
Quitridiomicetos/isolamento & purificação
Rana catesbeiana/microbiologia
[Mh] Termos MeSH secundário: Animais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170601
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0177860


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[PMID]:28539424
[Au] Autor:Sebe JY; Cho S; Sheets L; Rutherford MA; von Gersdorff H; Raible DW
[Ad] Endereço:Departments of Biology and Biological Structure, University of Washington, Seattle, Washington 98195-7420, draible@uw.edu sebe@uw.edu.
[Ti] Título:Ca -Permeable AMPARs Mediate Glutamatergic Transmission and Excitotoxic Damage at the Hair Cell Ribbon Synapse.
[So] Source:J Neurosci;37(25):6162-6175, 2017 Jun 21.
[Is] ISSN:1529-2401
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We report functional and structural evidence for GluA2-lacking Ca -permeable AMPARs (CP-AMPARs) at the mature hair cell ribbon synapse. By using the methodological advantages of three species (of either sex), we demonstrate that CP-AMPARs are present at the hair cell synapse in an evolutionarily conserved manner. Via a combination of electrophysiological and Ca imaging approaches in the larval zebrafish, we show that hair cell stimulation leads to robust Ca influx into afferent terminals. Prolonged application of AMPA caused loss of afferent terminal responsiveness, whereas blocking CP-AMPARs protects terminals from excitotoxic swelling. Immunohistochemical analysis of AMPAR subunits in mature rat cochlea show regions within synapses lacking the GluA2 subunit. Paired recordings from adult bullfrog auditory synapses demonstrate that CP-AMPARs mediate a major component of glutamatergic transmission. Together, our results support the importance of CP-AMPARs in mediating transmission at the hair cell ribbon synapse. Further, excess Ca entry via CP-AMPARs may underlie afferent terminal damage following excitotoxic challenge, suggesting that limiting Ca levels in the afferent terminal may protect against cochlear synaptopathy associated with hearing loss. A single incidence of noise overexposure causes damage at the hair cell synapse that later leads to neurodegeneration and exacerbates age-related hearing loss. A first step toward understanding cochlear neurodegeneration is to identify the cause of initial excitotoxic damage to the postsynaptic neuron. Using a combination of immunohistochemical, electrophysiological, and Ca imaging approaches in evolutionarily divergent species, we demonstrate that Ca -permeable AMPARs (CP-AMPARs) mediate glutamatergic transmission at the adult auditory hair cell synapse. Overexcitation of the terminal causes Ca accumulation and swelling that can be prevented by blocking CP-AMPARs. We demonstrate that CP-AMPARs mediate transmission at this first-order sensory synapse and that limiting Ca accumulation in the terminal may protect against hearing loss.
[Mh] Termos MeSH primário: Cálcio/metabolismo
Ácido Glutâmico/fisiologia
Células Ciliadas Auditivas/fisiologia
Receptores de AMPA/metabolismo
Sinapses/fisiologia
Transmissão Sináptica/fisiologia
[Mh] Termos MeSH secundário: Animais
Animais Geneticamente Modificados
Fenômenos Eletrofisiológicos/fisiologia
Feminino
Masculino
Estimulação Física
Terminações Pré-Sinápticas/fisiologia
Rana catesbeiana
Ratos
Ratos Wistar
Peixe-Zebra
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, AMPA); 3KX376GY7L (Glutamic Acid); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1523/JNEUROSCI.3644-16.2017


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[PMID]:28478504
[Au] Autor:You M; Mou Z
[Ad] Endereço:Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Institution of Biomedical Engineering, Jinan University, Guangzhou, Guangdong, 510632, China.
[Ti] Título:Model study of combined electrical and near-infrared neural stimulation on the bullfrog sciatic nerve.
[So] Source:Lasers Med Sci;32(5):1163-1172, 2017 Jul.
[Is] ISSN:1435-604X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This paper implemented a model study of combined electrical and near-infrared (808 nm) neural stimulation (NINS) on the bullfrog sciatic nerve. The model includes a COMSOL model to calculate the electric-field distribution of the surrounding area of the nerve, a Monte Carlo model to simulate light transport and absorption in the bullfrog sciatic nerve during NINS, and a NEURON model to simulate the neural electrophysiology changes under electrical stimulus and laser irradiation. The optical thermal effect is considered the main mechanism during NINS. Therefore, thermal change during laser irradiation was calculated by the Monte Carlo method, and the temperature distribution was then transferred to the NEURON model to stimulate the sciatic nerve. The effects on thermal response by adjusting the laser spot size, energy of the beam, and the absorption coefficient of the nerve are analyzed. The effect of the ambient temperature on the electrical stimulation or laser stimulation and the interaction between laser irradiation and electrical stimulation are also studied. The results indicate that the needed stimulus threshold for neural activation or inhibition is reduced by laser irradiation. Additionally, the needed laser energy for blocking the action potential is reduced by electrical stimulus. Both electrical and laser stimulation are affected by the ambient temperature. These results provide references for subsequent animal experiments and could be of great help to future basic and applied studies of infrared neural stimulation (INS).
[Mh] Termos MeSH primário: Raios Infravermelhos
Modelos Biológicos
Neurônios/efeitos da radiação
Rana catesbeiana/fisiologia
Nervo Isquiático/efeitos da radiação
[Mh] Termos MeSH secundário: Potenciais de Ação/efeitos da radiação
Animais
Simulação por Computador
Estimulação Elétrica
Eletrodos
Lasers
Modelos Animais
Método de Monte Carlo
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170508
[St] Status:MEDLINE
[do] DOI:10.1007/s10103-017-2222-x


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[PMID]:28409414
[Au] Autor:Vasconcelos AM; Daam MA; de Resende JC; Casali-Pereira MP; Espíndola ELG
[Ad] Endereço:NEEA/CRHEA/SHS, São Carlos Engineering School, University of São Paulo, Av. Trabalhador São Carlense, 400, 13.560-970, São Carlos, Brazil.
[Ti] Título:Survival and development of bullfrog tadpoles in microcosms treated with abamectin.
[So] Source:Ecotoxicology;26(6):729-737, 2017 Aug.
[Is] ISSN:1573-3017
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:As compared to other aquatic taxonomic groups, few studies have been conducted so far evaluating the potential risks of pesticides to amphibians. Furthermore, most existing studies with amphibians consist of acute laboratory toxicity tests that mostly only evaluated single peak pesticide exposure. In the present study, potential chronic effects of single and repeated abamectin applications on the survival and development of L. catesbeianus tadpoles under (semi-) field conditions were evaluated. To this end, tadpoles were housed in microcosms treated with single or repeated applications of abamectin (as the commercial product Vertimec® 18 EC). The single application level corresponded to the previously established laboratory 96 h LC50 of the test organism, whereas the repeated application was based on abamectin concentrations likely to occur in runoff water from agricultural areas where Vertimec® 18 EC is applied. Under semi-field conditions, toxicity after the single application was greater than would be expected from the laboratory toxicity value. Although the repeated application did not exert direct effects on tadpole survival, the observed delay in development may have pronounced effect on the fitness and survival of anuran populations in edge-of-field water bodies.
[Mh] Termos MeSH primário: Inseticidas/toxicidade
Ivermectina/análogos & derivados
Rana catesbeiana/fisiologia
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Agricultura
Animais
Ivermectina/toxicidade
Larva
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Water Pollutants, Chemical); 5U8924T11H (abamectin); 70288-86-7 (Ivermectin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE
[do] DOI:10.1007/s10646-017-1804-5


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[PMID]:28394282
[Au] Autor:Rutckeviski R; Xavier-Júnior FH; Morais AR; Alencar ÉN; Amaral-Machado L; Genre J; Gondim AD; Egito ES
[Ad] Endereço:Disperse Systems Laboratory (LaSiD), Pharmacy Department, Federal University of Rio Grande do Norte (UFRN), Av. General Gustavo de Cordeiro-SN-Petropolis, Natal 59010-180, Brazil. renatarut@hotmail.com.
[Ti] Título:Thermo-Oxidative Stability Evaluation of Bullfrog (Rana catesbeiana Shaw) Oil.
[So] Source:Molecules;22(4), 2017 Apr 10.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Bullfrog oil (BO), a natural product obtained from recycling of adipose tissue from the amphibian Shaw, has been recently evaluated as a therapeutic activity ingredient. This work aimed to evaluate the long-term and accelerated thermal oxidative stabilities of this product, which is a promising raw material for emulsion technology development. BO was extracted from amphibian adipose tissue at 70 °C with a yield of 60% ± 0.9%. Its main fatty acid compounds were oleic (30.0%) and eicosapentaenoic (17.6%) acids. Using titration techniques, BO showed peroxide, acid, iodine and saponification indices of 1.92 mEq·O2/kg, 2.95 mg·KOH/g oil, 104.2 g I2/100 g oil and 171.2 mg·KOH/g oil, respectively. In order to improve the accelerated oxidative stability of BO, synthetic antioxidants butylhydroxytoluene (BHT) and buthylhydroxyanisole (BHA) were used. The addition of BHT increased the oxidation induction time compared to the pure oil, or the oil containing BHA. From the results, the best oil-antioxidant mixture and concentration to increase the oxidative stability and allow the oil to be a stable raw material for formulation purposes was derived.
[Mh] Termos MeSH primário: Produtos Biológicos/química
Óleos/química
Rana catesbeiana
[Mh] Termos MeSH secundário: Animais
Ácidos Graxos/química
Oxirredução
Espectroscopia de Infravermelho com Transformada de Fourier
Temperatura Ambiente
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biological Products); 0 (Fatty Acids); 0 (Oils)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170411
[St] Status:MEDLINE



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