Base de dados : MEDLINE
Pesquisa : B01.050.150.900.090.608.700.500.480 [Categoria DeCS]
Referências encontradas : 253 [refinar]
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[PMID]:28167148
[Au] Autor:Aspbury AS; Grayson KL; Fantaye S; Nichols I; Myers-Burton M; Ortiz-Mangual X; Gabor CR
[Ad] Endereço:Department of Biology, Texas State University, 601 University Drive, San Marcos, TX 78666-4684, USA; Mountain Lake Biological Station, 240 Salt Pond Road, Pembroke, VA 24136, USA. Electronic address: aspbury@txstate.edu.
[Ti] Título:The association between male-biased sex ratio and indicators of stress in red-spotted newts.
[So] Source:Physiol Behav;173:156-162, 2017 May 01.
[Is] ISSN:1873-507X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In populations with a male-biased operational sex ratio, coercive mating by males can have fitness consequences for females. One component of reduced fitness for females in populations with a male-biased OSR may be greater activation of the stress response, resulting in higher corticosterone release rates (CORT; a glucocorticoid stress hormone in amphibians). We test the hypothesis that a male-biased sex ratio affects female activity and release rates of CORT and testosterone (T) in male and female red-spotted newts (Notophthalmus viridescens). First, we evaluated if chemical cues from a male-biased sex ratio affect activity and CORT release rates in females. We predicted that females exposed to chemical cues of three males would be less active and have higher CORT release rates than those exposed to chemical cues of one male. Second, we measured CORT release rates of red-spotted newts in field enclosures with either a male-biased or a female-biased sex ratio. We predicted that females in the male-biased treatment would have higher CORT and T release rates than those in a female-biased treatment, owing to higher levels of male harassment. We also predicted that males would have higher CORT and T release rates in male-biased treatments due to higher levels of male-male competition. Females were not less active in response to chemical cues from more males over fewer males, but there was a positive relationship between female activity and CORT when they were exposed to the cues of three males. We also found that females, but not males, in the male-biased sex ratio treatment had higher CORT and T release rates than those in the female-biased treatment. Our results support the hypothesis that a male-biased sex ratio leads to a higher stress response, which may underlie the observed decrease in immune function and body condition in previous work exposing female red-spotted newts to a male-biased sex ratio. This study furthers our understanding of the mechanistic basis for costs associated with a male-biased sex ratio in a pond-breeding amphibian.
[Mh] Termos MeSH primário: Notophthalmus viridescens/fisiologia
Caracteres Sexuais
Razão de Masculinidade
Comportamento Sexual Animal/fisiologia
Estresse Fisiológico/fisiologia
[Mh] Termos MeSH secundário: Análise de Variância
Animais
Viés
Cromatografia Líquida de Alta Pressão
Corticosterona/metabolismo
Sinais (Psicologia)
Feminino
Masculino
Testosterona/metabolismo
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
3XMK78S47O (Testosterone); W980KJ009P (Corticosterone)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170208
[St] Status:MEDLINE


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[PMID]:27265323
[Au] Autor:Keinath MC; Voss SR; Tsonis PA; Smith JJ
[Ad] Endereço:Department of Biology, University of Kentucky, Lexington, KY 40506, USA.
[Ti] Título:A linkage map for the Newt Notophthalmus viridescens: Insights in vertebrate genome and chromosome evolution.
[So] Source:Dev Biol;426(2):211-218, 2017 06 15.
[Is] ISSN:1095-564X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Genetic linkage maps are fundamental resources that enable diverse genetic and genomic approaches, including quantitative trait locus (QTL) analyses and comparative studies of genome evolution. It is straightforward to build linkage maps for species that are amenable to laboratory culture and genetic crossing designs, and that have relatively small genomes and few chromosomes. It is more difficult to generate linkage maps for species that do not meet these criteria. Here, we introduce a method to rapidly build linkage maps for salamanders, which are known for their enormous genome sizes. As proof of principle, we developed a linkage map with thousands of molecular markers (N=2349) for the Eastern newt (Notophthalmus viridescens). The map contains 12 linkage groups (152.3-934.7cM), only one more than the number of chromosome pairs. Importantly, this map was generated using RNA isolated from a single wild caught female and her 28 offspring. We used the map to reveal chromosome-scale conservation of synteny among N. viridescens, A. mexicanum (Urodela), and chicken (Amniota), and to identify large conserved segments between N. viridescens and Xenopus tropicalis (Anura). We also show that met1, a major effect QTL that regulates the expression of alternate metamorphic and paedomorphic modes of development in Ambystoma, associates with a chromosomal fusion that is not found in the N. viridescens map. Our results shed new light on the ancestral amphibian karyotype and reveal specific fusion and translocation events that shaped the genomes of three amphibian model taxa. The ability to rapidly build linkage maps for large salamander genomes will enable genetic and genomic analyses within this important vertebrate group, and more generally, empower comparative studies of vertebrate biology and evolution.
[Mh] Termos MeSH primário: Evolução Biológica
Cromossomos/genética
Ligação Genética
Genoma
Notophthalmus viridescens/genética
[Mh] Termos MeSH secundário: Ambystoma/genética
Anfíbios/genética
Animais
Galinhas/genética
Mapeamento Cromossômico
Cromossomos/ultraestrutura
Feminino
Marcadores Genéticos
Genótipo
Microdissecção e Captura a Laser
Masculino
Meiose/genética
Filogenia
Polimorfismo Genético
Locos de Características Quantitativas
Especificidade da Espécie
Sintenia
Translocação Genética
Vertebrados/genética
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Genetic Markers)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160607
[St] Status:MEDLINE


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[PMID]:27766381
[Au] Autor:Zeyl JN; Johnston CE
[Ad] Endereço:Fish Biodiversity Lab, School of Fisheries, Aquaculture and Aquatic Sciences, College of Agriculture, Auburn University, Auburn, AL, 36849, USA. jnz0002@tigermail.auburn.edu.
[Ti] Título:Comparative and developmental patterns of amphibious auditory function in salamanders.
[So] Source:J Comp Physiol A Neuroethol Sens Neural Behav Physiol;202(12):879-894, 2016 Dec.
[Is] ISSN:1432-1351
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Early amphibious tetrapods may have detected aquatic sound pressure using sound-induced lung vibrations, but their lack of tympanic middle ears would have restricted aerial sensitivity. Sharing these characteristics, salamanders could be models for the carryover of auditory function across an aquatic-terrestrial boundary without tympanic middle ears. We measured amphibious auditory evoked potential audiograms in five phylogenetically and ecologically distinct salamanders (Amphiuma means, Notophthalmus viridescens, Ambystoma talpoideum, Eurycea spp., and Plethodon glutinosus) and tested whether metamorphosis and terrestrial niche were linked to aerial sensitivity. Threshold differences between media varied between species. A. means' relative aerial sensitivity was greatest at 100 Hz and decreased with increasing frequency. In contrast, all other salamanders retained greater sensitivity up to 500 Hz, and in A. talpoideum and Eurycea, relative sensitivity at 500 Hz was higher than at 100 Hz. Aerial thresholds of terrestrial P. glutinosus above 200 Hz were similar to A. talpoideum and Eurycea, but lower than N. viridescens and A. means. Metamorphosis did not affect aerial sensitivity in N. viridescens or A. talpoideum. These results fail to support a hypothesis of terrestrial hearing specialization across ontogeny or phylogeny. We discuss methodological limitations to our amphibious comparisons and factors affecting variation in amphibious performance.
[Mh] Termos MeSH primário: Audição/fisiologia
Metamorfose Biológica/fisiologia
Urodelos/crescimento & desenvolvimento
Urodelos/fisiologia
[Mh] Termos MeSH secundário: Ar
Ambystoma/fisiologia
Animais
Audiometria
Limiar Auditivo/fisiologia
Evolução Biológica
Ecossistema
Potenciais Evocados Auditivos/fisiologia
Notophthalmus viridescens/fisiologia
Filogenia
Água
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
059QF0KO0R (Water)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171014
[Lr] Data última revisão:
171014
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161022
[St] Status:MEDLINE


  4 / 253 MEDLINE  
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[PMID]:27145786
[Au] Autor:Eastland A; Hornick J; Kawamura R; Nanavati D; Marko JF
[Ad] Endereço:Department of Molecular Biosciences, Northwestern University, Evanston, IL, 60208, USA.
[Ti] Título:Dependence of the structure and mechanics of metaphase chromosomes on oxidized cysteines.
[So] Source:Chromosome Res;24(3):339-53, 2016 09.
[Is] ISSN:1573-6849
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:We have found that reagents that reduce oxidized cysteines lead to destabilization of metaphase chromosome folding, suggesting that chemically linked cysteine residues may play a structural role in mitotic chromosome organization, in accord with classical studies by Dounce et al. (J Theor Biol 42:275-285, 1973) and Sumner (J Cell Sci 70:177-188, 1984a). Human chromosomes isolated into buffer unfold when exposed to dithiothreitol (DTT) or tris(2-carboxyethyl)phosphine (TCEP). In micromanipulation experiments which allow us to examine the mechanics of individual metaphase chromosomes, we have found that the gel-like elastic stiffness of native metaphase chromosomes is dramatically suppressed by DTT and TCEP, even before the chromosomes become appreciably unfolded. We also report protein labeling experiments on human metaphase chromosomes which allow us to tag oxidized and reduction-sensitive cysteine residues. PAGE analysis using fluorescent labels shows a small number of labeled bands. Mass spectrometry analysis of similarly labeled proteins provides a list of candidates for proteins with oxidized cysteines involved in chromosome organization, notably including components of condensin I, cohesin, the nucleosome-interacting proteins RCC1 and RCC2, as well as the RNA/DNA-binding protein NONO/p54NRB.
[Mh] Termos MeSH primário: Proteínas Cromossômicas não Histona/química
Cromossomos Humanos/química
Cromossomos Humanos/ultraestrutura
Cisteína/química
Metáfase/genética
[Mh] Termos MeSH secundário: Adenosina Trifosfatases/metabolismo
Animais
Proteínas de Ciclo Celular/metabolismo
Linhagem Celular
Proteínas Cromossômicas não Histona/metabolismo
Proteínas de Ligação a DNA/metabolismo
Ditiotreitol/química
Eletroforese em Gel Bidimensional
Fatores de Troca do Nucleotídeo Guanina/metabolismo
Células HEK293
Seres Humanos
Cariótipo
Espectrometria de Massas
Micromanipulação
Complexos Multiproteicos/metabolismo
Notophthalmus viridescens/genética
Proteínas Associadas à Matriz Nuclear/metabolismo
Proteínas Nucleares/metabolismo
Fatores de Transcrição de Octâmero/metabolismo
Oxirredução
Fosfinas/química
Proteínas de Ligação a RNA/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Cell Cycle Proteins); 0 (Chromosomal Proteins, Non-Histone); 0 (DNA-Binding Proteins); 0 (Guanine Nucleotide Exchange Factors); 0 (Multiprotein Complexes); 0 (NONO protein, human); 0 (Nuclear Matrix-Associated Proteins); 0 (Nuclear Proteins); 0 (Octamer Transcription Factors); 0 (Phosphines); 0 (RCC1 protein, human); 0 (RCC2 protein, human); 0 (RNA-Binding Proteins); 0 (cohesins); 0 (condensin complexes); 22OAC2MO2S (tris(2-carboxyethyl)phosphine); EC 3.6.1.- (Adenosine Triphosphatases); K848JZ4886 (Cysteine); T8ID5YZU6Y (Dithiothreitol)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170902
[Lr] Data última revisão:
170902
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160506
[St] Status:MEDLINE
[do] DOI:10.1007/s10577-016-9528-6


  5 / 253 MEDLINE  
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[PMID]:26934225
[Au] Autor:Sugiura T; Wang H; Barsacchi R; Simon A; Tanaka EM
[Ad] Endereço:DFG Research Center for Regenerative Therapies (CRTD), Technische Universität Dresden, Fetscherstrasse 105, 01307 Dresden, Germany.
[Ti] Título:MARCKS-like protein is an initiating molecule in axolotl appendage regeneration.
[So] Source:Nature;531(7593):237-40, 2016 Mar 10.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Identifying key molecules that launch regeneration has been a long-sought goal. Multiple regenerative animals show an initial wound-associated proliferative response that transits into sustained proliferation if a considerable portion of the body part has been removed. In the axolotl, appendage amputation initiates a round of wound-associated cell cycle induction followed by continued proliferation that is dependent on nerve-derived signals. A wound-associated molecule that triggers the initial proliferative response to launch regeneration has remained obscure. Here, using an expression cloning strategy followed by in vivo gain- and loss-of-function assays, we identified axolotl MARCKS-like protein (MLP) as an extracellularly released factor that induces the initial cell cycle response during axolotl appendage regeneration. The identification of a regeneration-initiating molecule opens the possibility of understanding how to elicit regeneration in other animals.
[Mh] Termos MeSH primário: Ambystoma mexicanum/fisiologia
Extremidades/fisiologia
Peptídeos e Proteínas de Sinalização Intracelular/metabolismo
Proteínas de Membrana/metabolismo
Regeneração/fisiologia
[Mh] Termos MeSH secundário: Ambystoma mexicanum/lesões
Amputação Traumática/metabolismo
Animais
Ciclo Celular/genética
Proliferação Celular/genética
Clonagem Molecular
Extremidades/lesões
Seres Humanos
Peptídeos e Proteínas de Sinalização Intracelular/genética
Peptídeos e Proteínas de Sinalização Intracelular/secreção
Proteínas de Membrana/genética
Proteínas de Membrana/secreção
Camundongos
Dados de Sequência Molecular
Fibras Musculares Esqueléticas/citologia
Fibras Musculares Esqueléticas/fisiologia
Substrato Quinase C Rico em Alanina Miristoilada
Notophthalmus viridescens/genética
Notophthalmus viridescens/lesões
Notophthalmus viridescens/fisiologia
Cauda/citologia
Cauda/lesões
Cauda/fisiologia
Cicatrização/fisiologia
Xenopus
Peixe-Zebra
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Intracellular Signaling Peptides and Proteins); 0 (MARCKS protein, human); 0 (Marcks protein, mouse); 0 (Membrane Proteins); 125267-21-2 (Myristoylated Alanine-Rich C Kinase Substrate)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160303
[St] Status:MEDLINE
[do] DOI:10.1038/nature16974


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[PMID]:26655977
[Au] Autor:De Lisle SP; Rowe L
[Ad] Endereço:Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario M5S 3B2, Canada.
[Ti] Título:Ecological Character Displacement between the Sexes.
[So] Source:Am Nat;186(6):693-707, 2015 Dec.
[Is] ISSN:1537-5323
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Theory suggests that the evolution of sexual dimorphism in ecologically relevant traits can evolve purely through competition between the sexes for a shared resource. Although more parsimonious hypotheses exist for the evolution of ecological sexual dimorphisms, there are some underappreciated reasons to expect that competition may often play some role in the evolution of sexual dimorphism. Here, we build on past work to outline a set of sufficient criteria to demonstrate a role for resource competition in the evolution of sexual dimorphism, the most critical of which is that resource competition can be directly linked to sexual divergence along the axis of ecologically relevant dimorphism. We then compare the geometry of fitness surfaces across experimental manipulations of density and sex ratio in a semiaquatic salamander (Notophthalmus viridescens). We find consistent disruptive selection on multivariate sexual dimorphism in feeding morphology, which increases in strength with density. Fitness and the strength of divergent selection are negative-frequency dependent in the manner expected under competition-driven divergence between the sexes. Our results constitute direct evidence of resource competition as a driver of sexually antagonist selection and consequently the evolution of sexual dimorphism, providing an illustration of how cause and effect can be separated in studies of sexual divergence in morphology and ecology. We suggest that resource competition may often contribute to sexual divergence jointly with other sources of sex-biased selection, especially when ecological opportunity is sex specific.
[Mh] Termos MeSH primário: Comportamento Competitivo
Notophthalmus viridescens/fisiologia
Caracteres Sexuais
[Mh] Termos MeSH secundário: Animais
Comportamento Animal
Evolução Biológica
Tamanho Corporal
Comportamento Alimentar
Feminino
Cabeça/anatomia & histologia
Masculino
Notophthalmus viridescens/anatomia & histologia
Densidade Demográfica
Razão de Masculinidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151215
[Lr] Data última revisão:
151215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151215
[St] Status:MEDLINE
[do] DOI:10.1086/683775


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[PMID]:26243583
[Au] Autor:Wang H; Lööf S; Borg P; Nader GA; Blau HM; Simon A
[Ad] Endereço:Department of Cell and Molecular Biology, Karolinska Institute, Solna, Sweden.
[Ti] Título:Turning terminally differentiated skeletal muscle cells into regenerative progenitors.
[So] Source:Nat Commun;6:7916, 2015 Aug 05.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The ability to repeatedly regenerate limbs during the entire lifespan of an animal is restricted to certain salamander species among vertebrates. This ability involves dedifferentiation of post-mitotic cells into progenitors that in turn form new structures. A long-term enigma has been how injury leads to dedifferentiation. Here we show that skeletal muscle dedifferentiation during newt limb regeneration depends on a programmed cell death response by myofibres. We find that programmed cell death-induced muscle fragmentation produces a population of 'undead' intermediate cells, which have the capacity to resume proliferation and contribute to muscle regeneration. We demonstrate the derivation of proliferating progeny from differentiated, multinucleated muscle cells by first inducing and subsequently intercepting a programmed cell death response. We conclude that cell survival may be manifested by the production of a dedifferentiated cell with broader potential and that the diversion of a programmed cell death response is an instrument to achieve dedifferentiation.
[Mh] Termos MeSH primário: Desdiferenciação Celular
Músculo Esquelético/fisiologia
Notophthalmus viridescens/fisiologia
Regeneração
[Mh] Termos MeSH secundário: Animais
Caspases/metabolismo
Morte Celular
Proliferação Celular
Feminino
Camundongos Endogâmicos NOD
Camundongos SCID
Fibras Musculares Esqueléticas
Músculo Esquelético/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
EC 3.4.22.- (Caspases)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:161025
[Lr] Data última revisão:
161025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150806
[St] Status:MEDLINE
[do] DOI:10.1038/ncomms8916


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[PMID]:25888438
[Au] Autor:Janssenswillen S; Willaert B; Treer D; Vandebergh W; Bossuyt F; Van Bocxlaer I
[Ad] Endereço:Biology Department, Amphibian Evolution Lab, Vrije Universiteit Brussel (VUB), Pleinlaan 2, B-1050, Brussels, Belgium. sljansse@vub.ac.be.
[Ti] Título:High pheromone diversity in the male cheek gland of the red-spotted newt Notophthalmus viridescens (Salamandridae).
[So] Source:BMC Evol Biol;15:54, 2015 Mar 25.
[Is] ISSN:1471-2148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Male salamanders (Urodela) often make use of pheromones that are produced in sexually dimorphic glands to persuade the female into courtship and mating. The mental gland of lungless salamanders (Plethodontidae) and dorsal cloacal glands (or abdominal glands) of newts (Salamandridae) have been particularly well studied in that respect. In both families, sodefrin precursor-like factor (SPF) proteins have been identified as major components of the courtship pheromone system. However, similar to plethodontids, some newts also make use of subtle head glands during courtship, but few pheromones have been characterized from such structures. Males of red-spotted newts (Notophthalmus viridescens, Salamandridae) have both cloacal and cheek (genial) glands, and are known to apply secretions to the female's nose by both tail-fanning and cheek-rubbing. Here we combined transcriptomic and phylogenetic analyses to investigate the presence, diversity and evolution of SPF proteins in the cloacal and cheek glands of this species. RESULTS: Our analyses indicate that the cheek glands of male N. viridescens produce a similar amount and diversity of SPF isoforms as the cloacal glands in this species. Expression in other tissues was much lower, suggesting that both male-specific courtship glands secrete SPF pheromones during courtship. Our phylogenetic analyses show that N. viridescens expresses a combination of isoforms that stem from four highly diverged evolutionary lineages of SPF variants, that together form a basis for the broad diversity of SPF precursors in the breeding glands. CONCLUSIONS: The similar SPF expression of cheek and cloacal glands suggests that this protein family is used for pheromone signalling through cheek rubbing in the red-spotted newt. Since several male salamandrids in other genera have comparable head glands, SPF application via other glands than the cloacal glands may be more widespread than currently appreciated in salamandrids.
[Mh] Termos MeSH primário: Notophthalmus viridescens/fisiologia
[Mh] Termos MeSH secundário: Animais
Corte
Glândulas Exócrinas/química
Feminino
Masculino
Oligopeptídeos/química
Oligopeptídeos/genética
Oligopeptídeos/metabolismo
Feromônios/química
Feromônios/genética
Feromônios/metabolismo
Filogenia
Proteínas/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Oligopeptides); 0 (Pheromones); 0 (Proteins); 0 (sodefrin)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:151111
[Lr] Data última revisão:
151111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150419
[St] Status:MEDLINE
[do] DOI:10.1186/s12862-015-0333-1


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[PMID]:25740498
[Au] Autor:Looso M; Braun T
[Ad] Endereço:Max-Planck-Institute for Heart and Lung Research, Ludwigstrasse 43, 61231, Bad Nauheim, Germany, Mario.Looso@mpi-bn.mpg.de.
[Ti] Título:Data mining in newt-omics, the repository for omics data from the newt.
[So] Source:Methods Mol Biol;1290:337-51, 2015.
[Is] ISSN:1940-6029
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Salamanders are an excellent model organism to study regenerative processes due to their unique ability to regenerate lost appendages or organs. Straightforward bioinformatics tools to analyze and take advantage of the growing number of "omics" studies performed in salamanders were lacking so far. To overcome this limitation, we have generated a comprehensive data repository for the red-spotted newt Notophthalmus viridescens, named newt-omics, merging omics style datasets on the transcriptome and proteome level including expression values and annotations. The resource is freely available via a user-friendly Web-based graphical user interface ( http://newt-omics.mpi-bn.mpg.de) that allows access and queries to the database without prior bioinformatical expertise. The repository is updated regularly, incorporating new published datasets from omics technologies.
[Mh] Termos MeSH primário: Biologia Computacional
Mineração de Dados/métodos
Notophthalmus viridescens/genética
Notophthalmus viridescens/metabolismo
[Mh] Termos MeSH secundário: Animais
Gráficos por Computador
Bases de Dados Genéticas
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Interface Usuário-Computador
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (RNA, Messenger)
[Em] Mês de entrada:1511
[Cu] Atualização por classe:150305
[Lr] Data última revisão:
150305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150306
[St] Status:MEDLINE
[do] DOI:10.1007/978-1-4939-2495-0_26


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[PMID]:25740479
[Au] Autor:Kirkham M; Joven A
[Ad] Endereço:Department of Cell and Molecular Biology, Karolinska Institutet, Berzelius väg 35, Stockholm, 171 77, Sweden, matthew.kirkham@ki.se.
[Ti] Título:Studying newt brain regeneration following subtype specific neuronal ablation.
[So] Source:Methods Mol Biol;1290:91-9, 2015.
[Is] ISSN:1940-6029
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The realization that neuronal injury does not result in permanent functional or cellular loss in all vertebrates has fascinated regenerative biologists. Neuronal regeneration occurs in a subset of species, including lizards, teleost fish, axolotls, and newts. One tool for studying neuronal regeneration in the adult brain is intraventricular injection of selective neuronal toxins, which leads to loss of subpopulations of neurons. To trace cells involved in the regeneration process, plasmids encoding reporter proteins can be electroporated in vivo into the cells of interest. This protocol describes methods to label the ependymoglial cells of the brain of the red spotted newt Notophthalmus viridescens and follow their response after ablation of dopaminergic neurons.
[Mh] Termos MeSH primário: Encéfalo/citologia
Encéfalo/fisiologia
Neurônios/citologia
Neurônios/efeitos dos fármacos
Notophthalmus viridescens/fisiologia
Oxidopamina/toxicidade
Regeneração
[Mh] Termos MeSH secundário: Animais
Eletroporação
Genes Reporter/genética
Injeções Intraventriculares
Neurônios/metabolismo
Oxidopamina/administração & dosagem
Plasmídeos/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
8HW4YBZ748 (Oxidopamine)
[Em] Mês de entrada:1511
[Cu] Atualização por classe:150305
[Lr] Data última revisão:
150305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150306
[St] Status:MEDLINE
[do] DOI:10.1007/978-1-4939-2495-0_7



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