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[PMID]: 29377917 [Au] Autor: Xu FQ; Li A; Lan JJ; Wang YM; Yan MJ; Lian SY; Wu X [Ad] Endereço: College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian, People's Republic of China. [Ti] Título: Study of formation of green eggshell color in ducks through global gene expression. [So] Source: PLoS One;13(1):e0191564, 2018. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The green eggshell color produced by ducks is a threshold trait that can be influenced by various factors, such as hereditary, environment and nutrition. The aim of this study was to investigate the genetic regulation of the formation of eggs with green shells in Youxian ducks. We performed integrative analysis of mRNAs and miRNAs expression profiling in the shell gland samples from ducks by RNA-Seq. We found 124 differentially expressed genes that were associated with various pathways, such as the ATP-binding cassette (ABC) transporter and solute carrier supper family pathways. A total of 31 differentially expressed miRNAs were found between ducks laying green eggs and white eggs. KEGG pathway analysis of the predicted miRNA target genes also indicated the functional characteristics of these miRNAs; they were involved in the ABC transporter pathway and the solute carrier (SLC) supper family. Analysis with qRT-PCR was applied to validate the results of global gene expression, which showed a correlation between results obtained by RNA-seq and RT-qPCR. Moreover, a miRNA-mRNA interaction network was established using correlation analysis of differentially expressed mRNA and miRNA. Compared to ducks that lay white eggs, ducks that lay green eggs include six up-regulated miRNAs that had regulatory effects on 35 down-regulated genes, and seven down-regulated miRNAs which influenced 46 up-regulated genes. For example, the ABC transporter pathway could be regulated by expressing gga-miR-144-3p (up-regulated) with ABCG2 (up-regulated) and other miRNAs and genes. This study provides valuable information about mRNA and miRNA regulation in duck shell gland tissues, and provides foundational information for further study on the eggshell color formation and marker-assisted selection for Youxian duck breeding. [Mh] Termos MeSH primário: Cor Casca de Ovo/metabolismo Expressão Gênica [Mh] Termos MeSH secundário: Animais Patos Reação em Cadeia da Polimerase em Tempo Real Análise de Sequência de RNA [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180130 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0191564

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[PMID]: 29370857 [Au] Autor: Järhult JD [Ad] Endereço: Zoonosis Science Center, Department of Medical Sciences, Uppsala University, 75185, Uppsala, Sweden. josef.jarhult@medsci.uu.se. [Ti] Título: Environmental resistance development to influenza antivirals: a case exemplifying the need for a multidisciplinary One Health approach including physicians. [So] Source: Acta Vet Scand;60(1):6, 2018 Jan 25. [Is] ISSN: 1751-0147 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: A multidisciplinary approach is a prerequisite for One Health. Physicians are important players in the One Health team, yet they are often hard to convince of the benefits of the One Health approach. Here, the case for multidisciplinarity including physicians is made using the example of environmental resistance development to influenza antivirals. Neuraminidase inhibitors are the major class of anti-influenza pharmaceuticals, and extensively stockpiled globally as a cornerstone of pandemic preparedness, especially important in the first phase before vaccines can be mass-produced. The active metabolite of oseltamivir that is excreted from treated patients degrades poorly in conventional sewage treatment processes and has been found in river waters. Dabbling ducks constitute the natural influenza A virus reservoir and often reside near sewage treatment plant outlets, where they may be exposed to neuraminidase inhibitor residues. In vivo experiments using influenza-infected Mallards exposed to neuraminidase inhibitors present in their water have shown resistance development and persistence, demonstrating that resistance may be induced and become established in the influenza strains circulating in natural hosts. Neuraminidase inhibitor resistance genes may become part of a human-adapted influenza virus with pandemic potential through reassortment or direct transmission. A pandemic caused by a neuraminidase inhibitor-resistant influenza virus is a serious threat as the first line defense in pandemic preparedness would be disarmed. To assess the risk for environmental influenza resistance development, a broad multidisciplinary team containing chemists, social scientists, veterinarians, biologists, ecologists, virologists, epidemiologists, and physicians is needed. Information about One Health early in high school and undergraduate training, an active participation of One Health-engaged physicians in the debate, and more One Health-adapted funding and publication possibilities are suggested to increase the possibility to engage physicians. [Mh] Termos MeSH primário: Antivirais/análise Antivirais/metabolismo Resistência a Medicamentos/fisiologia Saúde Única Médicos [Mh] Termos MeSH secundário: Animais Antivirais/uso terapêutico Reservatórios de Doenças/virologia Patos Seres Humanos Influenza Humana/tratamento farmacológico Comunicação Interdisciplinar [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Antiviral Agents) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180227 [Lr] Data última revisão: 180227 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180127 [St] Status: MEDLINE [do] DOI: 10.1186/s13028-018-0360-1

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[PMID]: 28464791 [Au] Autor: Duggan BM; Rae AM; Clements DN; Hocking PM [Ad] Endereço: The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK. Brendan.Duggan@roslin.ed.ac.uk. [Ti] Título: Higher heritabilities for gait components than for overall gait scores may improve mobility in ducks. [So] Source: Genet Sel Evol;49(1):42, 2017 05 02. [Is] ISSN: 1297-9686 [Cp] País de publicação: France [La] Idioma: eng [Ab] Resumo: BACKGROUND: Genetic progress in selection for greater body mass and meat yield in poultry has been associated with an increase in gait problems which are detrimental to productivity and welfare. The incidence of suboptimal gait in breeding flocks is controlled through the use of a visual gait score, which is a subjective assessment of walking ability of each bird. The subjective nature of the visual gait score has led to concerns over its effectiveness in reducing the incidence of suboptimal gait in poultry through breeding. The aims of this study were to assess the reliability of the current visual gait scoring system in ducks and to develop a more objective method to select for better gait. RESULTS: Experienced gait scorers assessed short video clips of walking ducks to estimate the reliability of the current visual gait scoring system. Kendall's coefficients of concordance between and within observers were estimated at 0.49 and 0.75, respectively. In order to develop a more objective scoring system, gait components were visually scored on more than 4000 pedigreed Pekin ducks and genetic parameters were estimated for these components. Gait components, which are a more objective measure, had heritabilities that were as good as, or better than, those of the overall visual gait score. CONCLUSIONS: Measurement of gait components is simpler and therefore more objective than the standard visual gait score. The recording of gait components can potentially be automated, which may increase accuracy further and may improve heritability estimates. Genetic correlations were generally low, which suggests that it is possible to use gait components to select for an overall improvement in both economic traits and gait as part of a balanced breeding programme. [Mh] Termos MeSH primário: Patos/genética Característica Quantitativa Herdável Velocidade de Caminhada/genética [Mh] Termos MeSH secundário: Animais Fenótipo Seleção Artificial [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 180218 [Lr] Data última revisão: 180218 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170504 [St] Status: MEDLINE [do] DOI: 10.1186/s12711-017-0317-2

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[PMID]: 29225048 [Au] Autor: Gao JF; Gao Y; Qiu JH; Chang QC; Zhang Y; Fang M; Wang CR [Ad] Endereço: College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang Province 163319, PR China; Department of Parasitology, Heilongjiang Institute of Veterinary Science, Qiqihar, Heilongjiang Province, PR China. [Ti] Título: De novo assembly and functional annotations of the transcriptome of Metorchis orientalis (trematoda: Opisthorchiidae). [So] Source: Exp Parasitol;184:90-96, 2018 Jan. [Is] ISSN: 1090-2449 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Metorchis orientalis is a neglected zoonotic parasite, living in the gallbladder and bile duct of poultry and some mammals as well as humans. In spite of its economic and medical importance, the information known about the transcriptome and genome of M. orientalis is limited. In this study, we performed de novo sequencing, transcriptome assembly and functional annotations of the adult M. orientalis, obtained about 77.4 million high-quality clean reads, among which the length of the transcript contigs ranged from 100 to 11,249 nt with mean length of 373 nt and N50 length of 919 nt. We then assembled 31,943 unigenes, of which 20,009 (62.6%) were annotated by BLASTn and BLASTx searches against the available database. Among these unigenes, 19,795 (62.0%), 3407 (10.7%), 10,620 (33.2%) of them had significant similarity in the NR, NT and Swiss-Prot databases, respectively; 5744 (18.0%) and 4678 (14.6%) unigenes were assigned to GO and COG, respectively; and 9099 (28.5%) unigenes were identified and mapped onto 256 pathways in the KEGG Pathway database. Furthermore, we found that 98 (1.08%) unigenes were related to bile secretion and 5 (0.05%) to primary bile acid biosynthesis pathways category. The characterization of these transcriptomic data has implications for the better understanding of the biology of M. orientalis, and will facilitate the development of intervention agents for this and other pathogenic flukes of human and animal health significance. [Mh] Termos MeSH primário: Doenças Negligenciadas/parasitologia Opisthorchidae/fisiologia Transcriptoma Infecções por Trematódeos/parasitologia Zoonoses/parasitologia [Mh] Termos MeSH secundário: Animais Ductos Biliares/parasitologia Biologia Computacional DNA Complementar/biossíntese Patos/parasitologia Doenças dos Peixes/parasitologia Doenças dos Peixes/transmissão Peixes Vesícula Biliar/parasitologia Sequenciamento de Nucleotídeos em Larga Escala Seres Humanos Opisthorchidae/genética Doenças das Aves Domésticas/parasitologia RNA de Helmintos/genética RNA de Helmintos/isolamento & purificação RNA Mensageiro/genética RNA Mensageiro/isolamento & purificação Sequenciamento Completo do Exoma [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (DNA, Complementary); 0 (RNA, Helminth); 0 (RNA, Messenger) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180205 [Lr] Data última revisão: 180205 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171212 [St] Status: MEDLINE

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[PMID]: 29272280 [Au] Autor: Yin H; Zhao L; Jiang X; Li S; Huo H; Chen H [Ad] Endereço: State Key Laboratory of Veterinary Biotechnology, Heilongjiang Provincial Key Laboratory of Laboratory Animal and Comparative Medicine, Harbin Veterinary Research Institute, the Chinese Academy of Agriculture Science, Harbin, P. R. China. [Ti] Título: DEV induce autophagy via the endoplasmic reticulum stress related unfolded protein response. [So] Source: PLoS One;12(12):e0189704, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Duck enteritis virus (DEV) can infect ducks, geese, and many other poultry species and leads to acute, septic and highly fatal infectious disease. Autophagy is an evolutionarily ancient pathway that plays an important role in many viral infections. We previously reported that DEV infection induces autophagy for its own benefit, but how this occurs remains unclear. In this study, endoplasmic reticulum (ER) stress was triggered by DEV infection, as demonstrated by the increased expression of the ER stress marker glucose-regulated protein 78 (GRP78) and the dilated morphology of the ER. Pathways associated with the unfolded protein response (UPR), including the PKR-like ER protein kinase (PERK) and inositol-requiring enzyme 1 (IRE1) pathways, but not the activating transcription factor 6 (ATF6) pathway, were activated in DEV-infected duck embryo fibroblast (DEF) cells. In addition, the knockdown of both PERK and IRE1 by small interfering RNAs (siRNAs) reduced the level of LC3-II and viral yields, which suggested that the PERK-eukaryotic initiation factor 2α (eIF2α) and IRE1-x-box protein1 (XBP1) pathways may contribute to DEV-induced autophagy. Collectively, these data offer new insight into the mechanisms of DEV -induced autophagy through activation of the ER stress-related UPR pathway. [Mh] Termos MeSH primário: Autofagia/fisiologia Estresse do Retículo Endoplasmático Mardivirus/fisiologia Resposta a Proteínas não Dobradas [Mh] Termos MeSH secundário: Animais Western Blotting Células Cultivadas Patos Eletroforese em Gel de Poliacrilamida Microscopia Eletrônica de Transmissão Interferência de RNA [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180116 [Lr] Data última revisão: 180116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171223 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0189704

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[PMID]: 29267387 [Au] Autor: Ma L; Sun K; Tu K; Pan L; Zhang W [Ad] Endereço: College of Food Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu, People's Republic of China. [Ti] Título: Identification of double-yolked duck egg using computer vision. [So] Source: PLoS One;12(12):e0190054, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The double-yolked (DY) egg is quite popular in some Asian countries because it is considered as a sign of good luck, however, the double yolk is one of the reasons why these eggs fail to hatch. The usage of automatic methods for identifying DY eggs can increase the efficiency in the poultry industry by decreasing egg loss during incubation or improving sale proceeds. In this study, two methods for DY duck egg identification were developed by using computer vision technology. Transmittance images of DY and single-yolked (SY) duck eggs were acquired by a CCD camera to identify them according to their shape features. The Fisher's linear discriminant (FLD) model equipped with a set of normalized Fourier descriptors (NFDs) extracted from the acquired images and the convolutional neural network (CNN) model using primary preprocessed images were built to recognize duck egg yolk types. The classification accuracies of the FLD model for SY and DY eggs were 100% and 93.2% respectively, while the classification accuracies of the CNN model for SY and DY eggs were 98% and 98.8% respectively. The CNN-based algorithm took about 0.12 s to recognize one sample image, which was slightly faster than the FLD-based (about 0.20 s). Finally, this work compared two classification methods and provided the better method for DY egg identification. [Mh] Termos MeSH primário: Computadores Gema de Ovo [Mh] Termos MeSH secundário: Algoritmos Animais Patos [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180116 [Lr] Data última revisão: 180116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171222 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0190054

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[PMID]: 29174810 [Au] Autor: Liu Y; Peng Y; Lu J; Wang J; Ma H; Song C; Liu B; Qiao Y; Yu W; Wu J; Chang J [Ad] Endereço: College of Chemistry and Molecular Engineering, Zhengzhou University, Henan 450001, PR China. [Ti] Título: Design, synthesis, and biological evaluation of new 1,2,3-triazolo-2'-deoxy-2'-fluoro- 4'-azido nucleoside derivatives as potent anti-HBV agents. [So] Source: Eur J Med Chem;143:137-149, 2018 Jan 01. [Is] ISSN: 1768-3254 [Cp] País de publicação: France [La] Idioma: eng [Ab] Resumo: Novel drugs are urgently needed to combat hepatitis B virus (HBV) infection due to drug-resistant virus. In this paper, a series of novel 4-monosubstituted 2'-deoxy-2'-ß-fluoro-4'-azido-ß-d-arabinofuranosyl 1,2,3-triazole nucleoside analogues (1a-g) were designed, synthesized and screened for in vitro anti-HBV activity. At 5.0 µM in the cellular model, all the synthetic compounds display activities comparable to that of the positive control, lamivudine at 20 µM. Of the compounds tested, the amide-substituted analogue (1a) shows the most promising anti-HBV activity and low cytotoxicity in the cell model. In particular, it retains excellent activity against lamivudine-resistant HBV mutants. In duck HBV (DHBV)-infected duck models, both the serum and liver DHBV DNA levels (67.4% and 53.3%, respectively) were reduced markedly by the treatment with 1a. Analysis of the structure of HBV polymer/1a-triphosphate (1a-TP) complex shows that 1a-TP is stabilized by specific van der Waals interactions with the enzyme residues arising from 4-amino-1,2,3-triazole and the 4'-azido group. [Mh] Termos MeSH primário: Antivirais/farmacologia Desenho de Drogas Vírus da Hepatite B do Pato/efeitos dos fármacos Vírus da Hepatite B/efeitos dos fármacos Hepatite B/tratamento farmacológico Monossacarídeos/farmacologia Nucleosídeos/farmacologia Triazóis/farmacologia [Mh] Termos MeSH secundário: Animais Antivirais/síntese química Antivirais/química Sobrevivência Celular/efeitos dos fármacos Modelos Animais de Doenças Relação Dose-Resposta a Droga Patos Células Hep G2 Vírus da Hepatite B/genética Seres Humanos Modelos Moleculares Estrutura Molecular Monossacarídeos/síntese química Monossacarídeos/química Nucleosídeos/síntese química Nucleosídeos/química Relação Estrutura-Atividade Triazóis/síntese química Triazóis/química Replicação Viral/efeitos dos fármacos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (2'-deoxy-2'-beta-fluoro-4'-azido-b-D-arabinofuranosyl 1,2,3-triazole); 0 (Antiviral Agents); 0 (Monosaccharides); 0 (Nucleosides); 0 (Triazoles) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180104 [Lr] Data última revisão: 180104 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171128 [St] Status: MEDLINE

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[PMID]: 29185933 [Au] Autor: Tang J; Hegeman MA; Hu J; Xie M; Shi W; Jiang Y; de Boer V; Guo Y; Hou S; Keijer J [Ad] Endereço: 1Institute of Animal Sciences,Chinese Academy of Agricultural Sciences,Beijing100193,People's Republic of China. [Ti] Título: Severe riboflavin deficiency induces alterations in the hepatic proteome of starter Pekin ducks. [So] Source: Br J Nutr;118(9):641-650, 2017 Nov. [Is] ISSN: 1475-2662 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Suboptimal vitamin B2 status is encountered globally. Riboflavin deficiency depresses growth and results in a fatty liver. The underlying mechanisms remain to be established and an overview of molecular alterations is lacking. We investigated hepatic proteome changes induced by riboflavin deficiency to explain its effects on growth and hepatic lipid metabolism. In all, 360 1-d-old Pekin ducks were divided into three groups of 120 birds each, with twelve replicates and ten birds per replicate. For 21 d, the ducks were fed ad libitum a control diet (CAL), a riboflavin-deficient diet (RD) or were pair-fed with the control diet to the mean daily intake of the RD group (CPF). When comparing RD with CAL and CPF, growth depression, liver enlargement, liver lipid accumulation and enhanced liver SFA (C6 : 0, C12 : 0, C16 : 0, C18 : 0) were observed. In RD, thirty-two proteins were enhanced and thirty-one diminished (>1·5-fold) compared with CAL and CPF. Selected proteins were confirmed by Western blotting. The diminished proteins are mainly involved in fatty acid ß-oxidation and the mitochondrial electron transport chain (ETC), whereas the enhanced proteins are mainly involved in TAG and cholesterol biosynthesis. RD causes liver lipid accumulation and growth depression probably by impairing fatty acid ß-oxidation and ETC. These findings contribute to our understanding of the mechanisms of liver lipid metabolic disorders due to RD. [Mh] Termos MeSH primário: Patos/sangue Fígado/metabolismo Proteoma/genética Deficiência de Riboflavina/sangue [Mh] Termos MeSH secundário: Alanina Transaminase/sangue Animais Aspartato Aminotransferases/sangue Glicemia/metabolismo Dieta Complexo de Proteínas da Cadeia de Transporte de Elétrons/genética Complexo de Proteínas da Cadeia de Transporte de Elétrons/metabolismo Metabolismo dos Lipídeos Masculino Mitocôndrias Hepáticas/metabolismo Proteoma/metabolismo Riboflavina/sangue Albumina Sérica/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Blood Glucose); 0 (Electron Transport Chain Complex Proteins); 0 (Proteome); 0 (Serum Albumin); EC 2.6.1.1 (Aspartate Aminotransferases); EC 2.6.1.2 (Alanine Transaminase); TLM2976OFR (Riboflavin) [Em] Mês de entrada: 1712 [Cu] Atualização por classe: 171211 [Lr] Data última revisão: 171211 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171130 [St] Status: MEDLINE [do] DOI: 10.1017/S0007114517002641

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[PMID]: 28954471 [Au] Autor: Guillam MT; Martin S; Le Guelennec M; Puterflam J; Le Bouquin S; Huneau-Salaün A [Ad] Endereço: SEPIA-Sante, 31 rue de Pontivy, 56150 Baud, France. mtguillam_sepia@orange.fr. [Ti] Título: Dust exposure and health of workers in duck hatcheries. [So] Source: Ann Agric Environ Med;24(3):360-365, 2017 Jul 04. [Is] ISSN: 1898-2263 [Cp] País de publicação: Poland [La] Idioma: eng [Ab] Resumo: OBJECTIVES: The objectives of this cross-sectional study were to investigate dust exposure and respiratory health of workers in duck hatcheries in western France. MATERIAL AND METHODS: Ninety volunteer workers, who work in sorting rooms and/or incubation rooms, participated in exposure assessments and medical examinations. Medical examinations were performed by occupational health practitioners.They filled-in a questionnaire with the workers, followed by a lung function test on each worker. General characteristics and prevalence of chronic respiratory symptoms were described in each type of working rooms. Associations between symptoms and exposure (working room or dust level) were studied in GEE multivariate models. RESULTS: Overall prevalence of chronic respiratory symptoms (cough, phlegm) and chronic bronchitis were similar or lower than in the reference population. However, prevalence of these symptoms was higher for those working in sorting rooms, that were associated with an increased risk of respiratory symptoms and decreased lung function. Respirable dust was also significantly associated with an increased risk of respiratory symptoms. The prevalence of asthma and rhinitis were well above those in the reference population, but did not vary among working rooms. Descriptive data suggested an occupational origin for some cases. CONCLUSIONS: Hatchery workers were at increased risk of compromised respiratory health due to dust exposure, particularly those who work in sorting rooms. Asthma and rhinitis were in excess in this population of workers. Thorough clinical examination of these workers should be performed and all exposures assessed. [Mh] Termos MeSH primário: Poluentes Ocupacionais do Ar/análise Patos Poeira/análise Doenças Profissionais/epidemiologia Exposição Ocupacional/efeitos adversos Exposição Ocupacional/análise Doenças Respiratórias/epidemiologia [Mh] Termos MeSH secundário: Adulto Poluentes Ocupacionais do Ar/efeitos adversos Criação de Animais Domésticos Animais Asma/epidemiologia Bronquite Crônica/epidemiologia Estudos Transversais Feminino França/epidemiologia Seres Humanos Masculino Meia-Idade Testes de Função Respiratória Rinite/epidemiologia Local de Trabalho [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Air Pollutants, Occupational); 0 (Dust) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171113 [Lr] Data última revisão: 171113 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170929 [St] Status: MEDLINE

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[PMID]: 28940019 [Au] Autor: Fehér E; Kaszab E; Forró B; Bali K; Marton S; Lengyel G; Bányai K [Ad] Endereço: Institute for Veterinary Medical Research, Centre of Agricultural Research, Hungarian Academy of Sciences, P.O. Box 18, 1581, Budapest, Hungary. [Ti] Título: Genome sequence of a mallard duck origin cyclovirus, DuACyV-1. [So] Source: Arch Virol;162(12):3925-3929, 2017 Dec. [Is] ISSN: 1432-8798 [Cp] País de publicação: Austria [La] Idioma: eng [Ab] Resumo: The genome sequence of a novel avian cyclovirus is described in this study. The genome size and orientation of predicted genes was similar to those described in other vertebrate and insect origin cycloviruses. The greatest genome sequence identity was shared with a dragonfly cyclovirus (nt, 60.6%). Phylogenetic analysis showed marginal relatedness with another avian cyclovirus, the chicken associated cyclovirus 1. In contrast, along a short fragment of the replication-associated protein coding gene (rep) (spanning nt 1240-1710) the duck origin cyclovirus was very similar to human origin and honey bee origin rep sequences (human - TN4, 98%; honey bee - hb10, 100%). Related cyclovirus strains existing amongst various animal species living in diverse ecosystems and separated by large geographic distances show the need for additional studies to better understand the ecology and epidemiology of cycloviruses. [Mh] Termos MeSH primário: Circoviridae/classificação Circoviridae/genética Patos/virologia Genoma Viral Análise de Sequência de DNA [Mh] Termos MeSH secundário: Animais Circoviridae/isolamento & purificação Ordem dos Genes Genes Virais Filogenia Homologia de Sequência [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171113 [Lr] Data última revisão: 171113 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170924 [St] Status: MEDLINE [do] DOI: 10.1007/s00705-017-3566-z

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1			PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
2	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
3	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2

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