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| [PMID]: | 28525869 |
| [Au] Autor: | Krieger LK; Szeitz A; Bandiera SM |
| [Ad] Endereço: | Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada. |
| [Ti] Título: | Hepatic microsomal metabolism of BDE-47 and BDE-99 by lesser snow geese and Japanese quail. |
| [So] Source: | Chemosphere;182:559-566, 2017 Sep. | | [Is] ISSN: | 1879-1298 |
| [Cp] País de publicação: | England |
| [La] Idioma: | eng |
| [Ab] Resumo: | In the present study, we investigated the oxidative biotransformation of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) and 2,2',4,4',5-pentabromodiphenyl ether (BDE-99) by liver microsomes from wild lesser snow geese (Chen caerulescens caerulescens) and domesticated Japanese quail (Coturnix japonica). Formation of hydroxy-metabolites was analyzed using an ultra-high performance liquid chromatography-tandem mass spectrometry-based method. Incubation of BDE-47 with avian liver microsomes produced sixteen hydroxy-metabolites, eight of which were identified using authentic standards. The major metabolites formed by liver microsomes from individual lesser snow geese were 4-hydroxy-2,2',3,4'-tetrabromodiphenyl ether (4-OH-BDE-42), 3-hydroxy-2,2',4,4'-tetrabromodiphenyl ether (3-OH-BDE-47), and 4'-hydroxy-2,2',4,5'-tetrabromodiphenyl ether (4'-OH-BDE-49). By comparison, 4-OH-BDE-42 and 4'-OH-BDE-49, but not 3-OH-BDE-47, were major metabolites of Japanese quail liver microsomes. Unidentified metabolites included monohydroxy- and dihydroxy-tetrabromodiphenyl ethers. Incubation of BDE-99 with avian liver microsomes produced seventeen hydroxy-metabolites, twelve of which were identified using authentic standards. The major metabolites formed by lesser snow goose liver microsomes were 2,4,5-tribromophenol, 3-OH-BDE-47, 4'-OH-BDE-49, 4-hydroxy-2,2',3,4',5-pentabromodiphenyl ether (4-OH-BDE-90), and 5'-hydroxy-2,2',4,4',5-pentabromodiphenyl ether (5'-OH-BDE-99). By comparison, the major metabolites produced by liver microsomes from Japanese quail included 6-hydroxy-2,2',4,4'-tetrabromodiphenyl ether (6-OH-BDE-47) and 2-hydroxy-2',3,4,4',5-pentabromodiphenyl ether (2-OH-BDE-123), but not 3-OH-BDE-47. Unidentified metabolites consisted of monohydroxy-pentabromodiphenyl ethers, monohydroxy-tetrabromodiphenyl ethers and dihydroxy-tetrabromodiphenyl ethers. Another difference between the two species was that formation rates of BDE-47 and BDE-99 metabolites were greater with liver microsomes from male than female Japanese quail, but a sex difference was not observed with lesser snow geese. |
| [Mh] Termos MeSH primário: |
Biotransformação
Coturnix
Gansos
Éteres Difenil Halogenados/metabolismo
Microssomos Hepáticos/metabolismo
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| [Mh] Termos MeSH secundário: |
Animais
Poluentes Ambientais/química
Poluentes Ambientais/metabolismo
Éteres Difenil Halogenados/química
Masculino
Oxirredução
Bifenil Polibromatos
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| [Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (2,2',4,4',5-brominated diphenyl ether); 0 (2,2',4,5'-tetrabromodiphenyl ether); 0 (6-OH-BDE-47); 0 (Environmental Pollutants); 0 (Halogenated Diphenyl Ethers); 0 (Polybrominated Biphenyls); 0N97R5X10X (2,2',4,4'-tetrabromodiphenyl ether); 7REL09ZX35 (pentabromodiphenyl ether) |
| [Em] Mês de entrada: | 1709 |
| [Cu] Atualização por classe: | 170915 |
[Lr] Data última revisão:
| 170915 |
| [Sb] Subgrupo de revista: | IM |
| [Da] Data de entrada para processamento: | 170520 |
| [St] Status: | MEDLINE |
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