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[PMID]:28644086
[Au] Autor:Carpenter JW; Tully TN; Gehring R; Guzman DS
[Ti] Título:Single-Dose Pharmacokinetics of Piperacillin/Tazobactam in Hispaniolan Amazon Parrots ( Amazona ventralis ).
[So] Source:J Avian Med Surg;31(2):95-101, 2017 Jun.
[Is] ISSN:1082-6742
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To determine the pharmacokinetics of piperacillin/tazobactam in Hispaniolan Amazon parrots ( Amazona ventralis ), 8 healthy adult parrots of both sexes were used in a 2-part study. In a pilot study, piperacillin (87 mg/kg) in combination with tazobactam (11 mg/kg) was administered intramuscularly (IM) to 2 birds, and blood samples were obtained at 0, 0.5, 1, 1.5, 2, 3, 4, 6, 8, and 10 hours after administration. Based on the results obtained, a main study was done in which piperacillin/tazobactam was administered at 2 different doses. In 3 birds, the initial dose of piperacillin (87 mg/kg)/tazobactam (11 mg/kg) IM was administered, and in 3 birds, the dose was doubled to piperacillin (174 mg/kg)/tazobactam (22 mg/kg) IM. In all 6 birds, blood samples were obtained at 0, 5, 15, and 30 minutes and at 1, 1.5, 2, 2.5, 3, and 4 hours after administration. Quantification of plasma piperacillin and tazobactam concentrations was determined by validated liquid chromatography-mass spectrometry assay. Pharmacokinetic parameters were determined by noncompartmental analysis. After intramuscular administration, the mean ± standard error values of T (h) was 0.52 ± 0.05 and 0.32 ± 0.07, T (h) was 0.28 ± 0.09 and 0.25 ± 0.10, C (µg/mL) was 86.34 ± 20.62 and 9.03 ± 2.88, and C /dose was 0.99 ± 0.24 and 0.83 ± 0.26 for piperacillin (87 mg/kg) and tazobactam (11 mg/kg), respectively. When the doses were doubled, the T (h) was 0.65 ± 0.08 and 0.34 ± 0.02, T (h) was 0.28 ± 0.12 and 0.14 ± 0.06, C (µg/mL) was 233.0 ± 6.08 and 22.13 ± 2.35, and C /dose was 1.34 ± 0.03 and 1.02 ± 0.11 for piperacillin and tazobactam, respectively. Results indicate that piperacillin is rapidly absorbed and reaches high initial concentrations; however, it is also rapidly eliminated in the Hispaniolan Amazon parrot, and tazobactam has similar pharmacokinetics as piperacillin. Administration of piperacillin at 87 mg/kg IM q3-4h is recommended for this species to control infections attributed to susceptible bacteria with a minimum inhibitory concentration of ≤4 µg/mL.
[Mh] Termos MeSH primário: Amazona/sangue
Antibacterianos/farmacocinética
Ácido Penicilânico/análogos & derivados
[Mh] Termos MeSH secundário: Animais
Antibacterianos/administração & dosagem
Área Sob a Curva
Esquema de Medicação
Meia-Vida
Ácido Penicilânico/administração & dosagem
Ácido Penicilânico/farmacocinética
Piperacilina/administração & dosagem
Piperacilina/farmacocinética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 157044-21-8 (piperacillin, tazobactam drug combination); 87-53-6 (Penicillanic Acid); X00B0D5O0E (Piperacillin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170824
[Lr] Data última revisão:
170824
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170624
[St] Status:MEDLINE
[do] DOI:10.1647/2015-131


  2 / 114 MEDLINE  
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[PMID]:28541145
[Au] Autor:Laniesse D; Guzman DS; Knych HK; Smith DA; Mosley C; Paul-Murphy JR; Beaufrère H
[Ti] Título:Pharmacokinetics of butorphanol tartrate in a long-acting poloxamer 407 gel formulation administered to Hispaniolan Amazon parrots (Amazona ventralis).
[So] Source:Am J Vet Res;78(6):688-694, 2017 Jun.
[Is] ISSN:1943-5681
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE To determine pharmacokinetics of butorphanol tartrate incorporated into poloxamer 407 (P407) after SC administration to Hispaniolan Amazon parrots (Amazona ventralis). ANIMALS 11 adult Hispaniolan Amazon parrots (6 males and 5 females; 11 to 27 years old). PROCEDURES A sterile formulation of butorphanol in P407 (But-P407) 25% (percentage determined as [weight of P407/weight of diluent] × 100]) was created (8.3 mg/mL). Five preliminary experiments (2 birds/experiment) were performed to determine the ideal dose for this species. The formulation then was administered (12.5 mg/kg, SC) to 8 birds. Blood samples were collected before (time 0) and 0.08, 0.5, 1, 2, 4, 8, 12, and 24 hours after drug administration. Some birds were used more than once, with a washout period of ≥ 3 months between subsequent treatments. Butorphanol concentrations were quantitated by use of liquid chromatography-tandem mass spectrometry. Pharmacokinetic analysis was performed by use of noncompartmental analysis. RESULTS Maximal plasma butorphanol concentration was reached at 1.31 hours. Plasma concentrations of butorphanol remained > 100 ng/mL for > 3 hours (all birds) or > 4 hours (5/8 birds) but < 8 hours (all birds). Half-life of the terminal slope was 3.41 hours. No adverse effects were detected. CONCLUSIONS AND CLINICAL RELEVANCE Butorphanol was absorbed well from the But-P407 25% by Hispaniolan Amazon parrots, and absorption followed a pharmacokinetic profile compatible with a sustained-release drug. A dose of 12.5 mg/kg, SC, would theoretically provide analgesia for 4 to 8 hours. No adverse effects were detected. Studies on the pharmacodynamics of this formulation are necessary to confirm the degree and duration of analgesia.
[Mh] Termos MeSH primário: Amazona/metabolismo
Analgesia/veterinária
Analgésicos Opioides/farmacocinética
Butorfanol/farmacocinética
Poloxâmero/farmacocinética
[Mh] Termos MeSH secundário: Amazona/sangue
Animais
Área Sob a Curva
Feminino
Meia-Vida
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics, Opioid); 106392-12-5 (Poloxamer); QV897JC36D (Butorphanol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.2460/ajvr.78.6.688


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[PMID]:28286082
[Au] Autor:Silva de Souza Matos L; Palme R; Silva Vasconcellos A
[Ad] Endereço:Programa de Pós-graduação em Biologia de Vertebrados, Pontifícia Universidade Católica de Minas Gerais, Av. Dom José Gaspar, 500, Prédio 41, Coração Eucarístico, Belo Horizonte, Minas Gerais CEP 30535-901, Brazil; Instituto Brasileiro do Meio Ambiente e dos Recursos Naturais Renováveis - IBAMA, Belo Horizonte, Minas Gerais, CEP 30110-051, Brazil.
[Ti] Título:Behavioural and hormonal effects of member replacement in captive groups of blue-fronted amazon parrots (Amazona aestiva).
[So] Source:Behav Processes;138:160-169, 2017 May.
[Is] ISSN:1872-8308
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Social species in captivity may face allostatic overload due to artificial grouping and other social constraints. In rescue centres, groups of psittacines are constantly mixed due to the arrival and/or release of individuals; this procedure is potentially harmful to animal welfare. This study aimed at evaluating the possible impacts of mate replacement on the stress levels of captive blue-fronted amazon parrots (Amazona aestiva). During five weeks, we recorded agonistic interactions and dropping-glucocorticoid metabolites (GCM) concentrations of individuals allocated in a group whose members were kept constant and in a group subjected to frequent member replacement. In both groups, non-linear hierarchies developed, without sex differences regarding aggression or hierarchical positions. The replacement of individuals had no effect on the number of agonistic interactions or on the animals' stress levels. In both groups, higher-ranking individuals had higher stress loads than subordinates. Our study, the first to investigate the social dynamics of A. aestiva, indicated that introducing or removing individuals in captive groups does not seem to affect the welfare of the birds in the short term. This information favours release and reintroduction programs and is relevant for conservation management of this, and possibly other parrot species with similar environmental requirements.
[Mh] Termos MeSH primário: Agressão/psicologia
Amazona
Glucocorticoides/análise
Estresse Psicológico/psicologia
[Mh] Termos MeSH secundário: Animais
Fezes/química
Hierarquia Social
Masculino
Caracteres Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucocorticoids)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170314
[St] Status:MEDLINE


  4 / 114 MEDLINE  
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[PMID]:28107068
[Au] Autor:Brady SM; Burgdorf-Moisuk A; Silverman S; Wack RF
[Ti] Título:Successful Treatment of Suspected Pulmonary Arterial Hypertension in a Mealy Amazon Parrot (Amazona farinose).
[So] Source:J Avian Med Surg;30(4):368-373, 2016 Dec.
[Is] ISSN:1082-6742
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A 25-year-old, male mealy Amazon parrot (Amazona farinose) with a history of polycythemia, hepatomegaly, and epistaxis was evaluated for progressive lethargy and anorexia. Clinical laboratory testing revealed severe polycythemia (71%), hypophosphatemia (1.6 mg/dL), and mild hypokalemia (2.8 mEq/L). Radiographs showed marked hepatomegaly and loss of air sac space. Despite supportive treatments, the bird's condition deteriorated, and it developed ataxia, was unable to fly, and became oxygen dependent. An echocardiogram, including an air bubble study, revealed a right-to-left atrial shunt and presumed pulmonary arterial hypertension. The bird was started on periodic phlebotomy (5-10 mL/kg q6wk) to reduce packed cell volume and sildenafil citrate (2.5 mg/kg PO q8h) for treatment of suspected pulmonary arterial hypertension. One week later, the patient was weaned off oxygen, and 24 days after initial presentation, the parrot was returned to its outdoor exhibit. Intermittent periods of increased respiratory rate and effort have been reported but have resolved without additional treatments. Epistaxis, once common in this bird, has not been noted since initiating treatment with sildenafil citrate 15 months ago.
[Mh] Termos MeSH primário: Amazona
Doenças das Aves/tratamento farmacológico
Hipertensão Pulmonar/veterinária
Citrato de Sildenafila/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Hipertensão Pulmonar/tratamento farmacológico
Masculino
Resultado do Tratamento
Vasodilatadores/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Vasodilator Agents); BW9B0ZE037 (Sildenafil Citrate)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE
[do] DOI:10.1647/2015-127


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[PMID]:28107066
[Au] Autor:Vergneau-Grosset C; Polley T; Holt DC; Vernau W; Paul-Murphy J
[Ti] Título:Hematologic, Plasma Biochemical, and Lipid Panel Reference Intervals in Orange-winged Amazon Parrots ( Amazona amazonica ).
[So] Source:J Avian Med Surg;30(4):335-344, 2016 Dec.
[Is] ISSN:1082-6742
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To establish reference intervals in orange-winged Amazon parrots ( Amazona amazonica ) for the complete blood count, plasma biochemical values, and lipid panel and to evaluate age- and sex-related variations, blood samples were obtained from 29 healthy juvenile and adult parrots. Concentrations of total protein, bile acids, phosphorus, total cholesterol, low-density-lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol were significantly higher in adult compared with juvenile birds, while uric acid concentration was significantly higher in juveniles. The white blood cell count, lymphocyte count, and phosphorus and potassium concentrations were significantly higher in females, while chloride concentration was significantly higher in males. In this species, direct measurement of LDL-C resulted in lower concentrations than LDL-C calculated with the Friedewald formula. Assessment of the agreement between the calculated and measured LDL-C concentrations indicated a systematic bias of 19.1 mg/dL and a proportional bias of 1.07. A correction factor of -19 mg/L could be applied to the Friedewald formula, to obtain a result closer to the measured LDL-C, providing clinically acceptable (<20% difference) agreement in 66% of the samples. Triglyceride concentrations within the range measured in healthy birds of the present study did not significantly affect the bias between calculated and directly measured LDL-C. Further studies are needed to investigate the impact of nutritional factors, genetics, and exercise on biochemistry and lipoprotein panel analytes in orange-winged Amazon parrots.
[Mh] Termos MeSH primário: Amazona/sangue
Análise Química do Sangue/veterinária
Lipídeos/sangue
Plasma/química
[Mh] Termos MeSH secundário: Animais
Proteínas Sanguíneas/análise
Contagem de Eritrócitos/veterinária
Feminino
Testes Hematológicos/veterinária
Contagem de Leucócitos/veterinária
Masculino
Valores de Referência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Proteins); 0 (Lipids)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE
[do] DOI:10.1647/2015-129


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[PMID]:28107063
[Au] Autor:Vaz FF; Locatelli-Dittrich R; Beltrame OC; Sipinski EA; Abbud MC; Sezerban RM
[Ti] Título:Hematologic and Biochemical Values of Wild Red-Tailed Amazon Parrot (Amazona brasiliensis) Nestlings With Abnormal Clinical Examination in Rasa Island, Brazil.
[So] Source:J Avian Med Surg;30(4):350-356, 2016 Dec.
[Is] ISSN:1082-6742
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The red-tailed Amazon parrot (Amazona brasiliensis) is an endangered psittacine species, but little information is available about abnormal clinical findings and hematologic and biochemical values of this species, which are important for monitoring the health of this population. To determine hematologic and biochemical values for wild red-tailed parrot nestlings exhibiting abnormal clinical findings, 31 nestlings from the Rasa Island (Paraná State, Southern Brazil) were physically restrained for clinical examination and blood sample collection. On physical examination, 26 birds had mild abnormalities and 5 had severe disorders. Parrots were divided into 5 groups according to the following clinical findings: presence of ectoparasites (group 1), respiratory disorders (group 2), chronic skin lesions caused by fly larvae (group 3), beak disorders (group 4), and severe clinical signs (group 5). Abnormal hematologic and biochemical findings in the nestlings were high total protein in group 3; low values for hemoglobin and mean corpuscular hemoglobin concentration in group 4; low glucose concentration, high mean absolute heterophil count, and high heterophil : lymphocyte ratio in group 5; high concentrations of total plasma protein in groups 3 and 4; and high globulin concentration in groups 3 and 5. In general, the population assessed was in good condition. These results provide a guide to the expected clinical findings associated with hematologic and biochemical concentrations in a population of free-living parrots with abnormal clinical examination findings. The data support the conservation planning and health monitoring of the endangered red-tailed Amazon parrot.
[Mh] Termos MeSH primário: Amazona/sangue
Animais Selvagens
Doenças das Aves/sangue
[Mh] Termos MeSH secundário: Animais
Doenças das Aves/diagnóstico
Brasil
Ilhas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE
[do] DOI:10.1647/2015-119


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[PMID]:27701767
[Au] Autor:Vaz FF; Locatelli-Dittrich R; Beltrame OC; Sipinski EA; Abbud MC; Sezerban RM
[Ad] Endereço:Department of Veterinary Medicine, Federal University of Parana, Curitiba, Brazil.
[Ti] Título:Hematologic and biochemical reference intervals of free-living Red-Tailed Amazon parrot (Amazona brasiliensis) nestlings on Rasa Island, Paraná, Brazil.
[So] Source:Vet Clin Pathol;45(4):615-622, 2016 Dec.
[Is] ISSN:1939-165X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The Red-Tailed Amazon parrot (Amazona brasiliensis) is an endangered species of the Psittaciformes. There is little information about hematologic and biochemical variables of this species. OBJECTIVES: The purpose of this study was to determine hematologic and biochemical RIs for free-living A brasiliensis nestlings on Rasa Island, Paraná, Brazil, and to compare the results between sexes. METHODS: Thirty-seven parrots were taken from their nests and physically restrained for clinical examination and blood collection. The sex was diagnosed by PCR using the blood samples collected. Reference intervals were determined as recommended by the ASVCP guidelines in healthy nestlings. The difference between groups was analyzed using the Mann-Whitney test or Student's t-test. RESULTS: Sexing revealed 12 females and 25 males. The RIs for the measured variables were as follows: RBC 1.1-2.6 × 10 /µL, PCV 29.1-50.3%, HGB 7.2-12.9 g/dL, MCV 152-293 fL, MCHC 22.2-28.4 g/dL, WBC 4.9-28.5 × 10 /µL, 1.2-16 × 10 /µL, lymphocytes 2.4-18.7 × 10 /µL, monocytes 0.0-1.0 × 10 /µL, eosinophils 0.0-0.9 × 10 /µL, 0.0-1.3 × 10 /µL, heterophil:lymphocyte ratio 0.0-2.2, plasma total solids 2.1-3.7 g/dL, uric acid 0.5-2.0 mg/dL, glucose 184.9-284.3 mg/dL, AST 100.3-226.6 U/L, LDH 178.1-927.7 U/L, CK 149.8-1144.0 U/L, cholesterol 137.5-256.9 mg/dL, total protein 1.8-3.0 g/dL, calcium 7.0-8.6 mg/dL, and phosphorus 2.9-6.1 mg/dL. Increased concentrations of cholesterol (P < .05) were observed in females. DISCUSSION: This is the first study to establish hematologic and biochemical RIs for free-living A brasiliensis nestlings on Rasa Island. Hematologic and biochemical variables are important tools for evaluating the health status of free-living birds, and also support conservation planning for endangered species.
[Mh] Termos MeSH primário: Amazona/sangue
[Mh] Termos MeSH secundário: Animais
Contagem de Células Sanguíneas/normas
Contagem de Células Sanguíneas/veterinária
Análise Química do Sangue/normas
Análise Química do Sangue/veterinária
Brasil
Espécies em Perigo de Extinção
Feminino
Testes Hematológicos/normas
Testes Hematológicos/veterinária
Masculino
Valores de Referência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161005
[St] Status:MEDLINE
[do] DOI:10.1111/vcp.12399


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[PMID]:27691968
[Au] Autor:Gustavsen KA; Stanhope KL; Lin AS; Graham JL; Havel PJ; Paul-Murphy JR
[Ti] Título:EFFECTS OF EXERCISE ON THE PLASMA LIPID PROFILE IN HISPANIOLAN AMAZON PARROTS (AMAZONA VENTRALIS) WITH NATURALLY OCCURRING HYPERCHOLESTEROLEMIA.
[So] Source:J Zoo Wildl Med;47(3):760-769, 2016 Sep.
[Is] ISSN:1042-7260
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hypercholesterolemia is common in psittacines, and Amazon parrots ( Amazona spp.) are particularly susceptible. Associations have been demonstrated between naturally occurring and experimentally induced hypercholesterolemia and atherosclerosis in psittacines. Daily exercise improves lipid metabolism in humans and other mammals, as well as pigeons and chickens, under varying experimental conditions. Hispaniolan Amazon parrots ( Amazona ventralis ) with naturally occurring hypercholesterolemia (343-576 mg/dl) were divided into two groups. An exercised group (n = 8) was housed as a flock and exercised daily with 30 min of aviary flight and 30 min walking on a rotating perch. A sedentary control group (n = 4) was housed in individual cages with no exercise regime. A plasma lipid panel, including total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, and triglycerides, was validated for this species. Body weight, chest girth, and the lipid panel were measured at 0, 61, and 105 days. Hematology and plasma biochemistry were measured at 0 and 105 days. Weight and girth were significantly lower in exercised than sedentary parrots at 61 and 105 days. HDL-C concentrations were significantly higher in exercised parrots at 61 days but returned to near baseline by 105 days. There were no significant changes in hematology, biochemistry, or other lipid panel parameters. Results were similar to studies in humans and animal models, in which increased HDL-C was the most consistent effect of exercise on circulating lipid and lipoprotein parameters. The return toward baseline HDL-C may have resulted from decreased participation in aviary flight. Additional investigation will be required to determine the amount of exercise and change in circulating lipid-related parameters necessary to improve long-term wellness in psittacine species predisposed to hypercholesterolemia.
[Mh] Termos MeSH primário: Amazona
Doenças das Aves/sangue
Hipercolesterolemia/veterinária
Lipídeos/sangue
Condicionamento Físico Animal/fisiologia
[Mh] Termos MeSH secundário: Animais
Feminino
Hipercolesterolemia/sangue
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lipids)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170107
[Lr] Data última revisão:
170107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161004
[St] Status:MEDLINE


  9 / 114 MEDLINE  
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[PMID]:27088739
[Au] Autor:Baine K; Hendrix DV; Kuhn SE; Souza MJ; Jones MP
[Ti] Título:The Efficacy and Safety of Topical Rocuronium Bromide to Induce Bilateral Mydriasis in Hispaniolan Amazon Parrots ( Amazona ventralis ).
[So] Source:J Avian Med Surg;30(1):8-13, 2016 Mar.
[Is] ISSN:1082-6742
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The efficacy and safety of topically applied rocuronium in Hispaniolan Amazon parrots ( Amazona ventralis ) was assessed in a group of 10 adult birds. A complete ophthalmic examination (including Schirmer tear test, ocular reflexes, applanation tonometry, fluorescein staining, and slit-lamp biomicroscopy) was performed, and rocuronium bromide (0.15 mg in both eyes) was administered. Pupillary light reflex (PLR) and pupillary diameter were recorded in a darkened room at the following time points: 0, 10, 20, 30, 40, 50, 60, 80, 100, 120, 140, 160, 180, 200, 220, 240, 300, and 360 minutes, and 24 hours. Fluorescein staining in both eyes was performed at 24 hours. By 10 minutes, PLR was absent in all birds (at 5 minutes, 8 birds; at 10 minutes, remaining 2 birds). Pupil diameter differed significantly from baseline at all time points. Additionally, PLR was decreased in 7/10 birds at 360 minutes and normal in all birds at 24 hours. Superficial corneal ulceration was observed at 24 hours in the left eye of 2/10 of the birds after fluorescein stain application. This study demonstrated that rocuronium bromide was an effective mydriatic agent in Hispaniolan Amazon parrots with rapid onset and prolonged duration of action.
[Mh] Termos MeSH primário: Amazona
Androstanóis/farmacologia
Midriáticos/farmacologia
[Mh] Termos MeSH secundário: Administração Tópica
Androstanóis/administração & dosagem
Androstanóis/efeitos adversos
Animais
Animais de Zoológico
Midriáticos/administração & dosagem
Midriáticos/efeitos adversos
Soluções Oftálmicas
Reflexo Pupilar/efeitos dos fármacos
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Androstanols); 0 (Mydriatics); 0 (Ophthalmic Solutions); WRE554RFEZ (rocuronium)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160419
[Lr] Data última revisão:
160419
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160419
[St] Status:MEDLINE
[do] DOI:10.1647/2015-083


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[PMID]:26684093
[Au] Autor:Petritz OA; Guzman DS; Gustavsen K; Wiggans KT; Kass PH; Houck E; Murphy CJ; Paul-Murphy J
[Ti] Título:Evaluation of the mydriatic effects of topical administration of rocuronium bromide in Hispaniolan Amazon parrots (Amazona ventralis).
[So] Source:J Am Vet Med Assoc;248(1):67-71, 2016 Jan 01.
[Is] ISSN:1943-569X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:UNLABELLED: OBJECTIVE :To determine the mydriatic effects of topical rocuronium bromide administration in Hispaniolan Amazon parrots (Amazona ventralis) and to identify any adverse effects associated with treatment. DESIGN: Randomized crossover study. ANIMALS: 8 healthy adult Hispaniolan Amazon parrots. PROCEDURES: Rocuronium bromide (20 µL/eye; 10 mg/mL) or saline (20 µL/eye; 0.9% NaCl) solution was administered in both eyes of each bird with a 26-day washout period. The birds were manually restrained in lateral recumbency with the apex of the cornea positioned upward for 2 minutes following administration in each eye. Infrared pupillometry and direct pupillary light reflex measurements were used to evaluate the mydriatic effects. Pupillary measurements were recorded prior to administration and every 20 minutes for 2 hours after administration, then hourly for a total of 7 hours. A brief physical examination was performed, direct pupillary light reflex was tested, and fluorescein staining was performed on each eye of each bird 24 hours after administration. RESULTS: A significant difference in pupillary diameter for the active versus control treatment group was noted from 20 to 360 minutes after drug administration, but not at 420 minutes. Minimal adverse effects were noted. Three birds had transient inferior eyelid paresis noted in both eyes after receiving rocuronium; 24 hours after the treatment, no differences in ocular measurements existed between the active and control treatments. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggested that topical rocuronium bromide administration may be safely used for pupillary dilation in Hispaniolan Amazon parrots and could be used for clinical evaluation, fundus imaging, and surgical interventions involving the lens and posterior segment in this species.
[Mh] Termos MeSH primário: Amazona
Androstanóis/farmacologia
Fármacos Neuromusculares não Despolarizantes/farmacologia
Pupila/efeitos dos fármacos
[Mh] Termos MeSH secundário: Administração Tópica
Androstanóis/administração & dosagem
Animais
Estudos Cross-Over
Fármacos Neuromusculares não Despolarizantes/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Androstanols); 0 (Neuromuscular Nondepolarizing Agents); WRE554RFEZ (rocuronium)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151219
[Lr] Data última revisão:
151219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151220
[St] Status:MEDLINE
[do] DOI:10.2460/javma.248.1.67



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