Base de dados : MEDLINE
Pesquisa : B01.050.150.900.248.815.350.200 [Categoria DeCS]
Referências encontradas : 305 [refinar]
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[PMID]:28662453
[Au] Autor:Gómez-Ramírez P; Bustnes JO; Eulaers I; Herzke D; Johnsen TV; Lepoint G; Pérez-García JM; García-Fernández AJ; Jaspers VLB
[Ad] Endereço:Department of Toxicology, Faculty of Veterinary Medicine, University of Murcia, Campus de Espinardo, 30100 Murcia, Spain. Electronic address: pilargomez@um.es.
[Ti] Título:Per- and polyfluoroalkyl substances in plasma and feathers of nestling birds of prey from northern Norway.
[So] Source:Environ Res;158:277-285, 2017 10.
[Is] ISSN:1096-0953
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Plasma samples from nestlings of two top predators, White-tailed eagle (Haliaeetus albicilla) and Northern goshawk (Accipiter gentilis) from northern Norway were analysed for a wide range of per- and polyfluoroalkyl substances (PFASs). Body feathers from the White-tailed eagles were also analysed and significant associations between specific PFASs in blood plasma and body feathers were found (0.36
[Mh] Termos MeSH primário: Águias/metabolismo
Exposição Ambiental
Poluentes Ambientais/metabolismo
Fluorcarbonetos/metabolismo
Falcões/metabolismo
[Mh] Termos MeSH secundário: Animais
Águias/sangue
Monitoramento Ambiental
Poluentes Ambientais/sangue
Plumas/química
Fluorcarbonetos/sangue
Falcões/sangue
Noruega
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Environmental Pollutants); 0 (Fluorocarbons)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171120
[Lr] Data última revisão:
171120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE


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[PMID]:28529085
[Au] Autor:Ingram T; Zuck J; Borges CR; Redig P; Sweazea KL
[Ad] Endereço:School of Nutrition and Health Promotion, Arizona State University.
[Ti] Título:Variations in native protein glycation and plasma antioxidants in several birds of prey.
[So] Source:Comp Biochem Physiol B Biochem Mol Biol;210:18-28, 2017 Aug.
[Is] ISSN:1879-1107
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Birds are an anomaly among vertebrates as they are remarkably long-lived despite having naturally high blood glucose and metabolic rates. For mammals, hyperglycemia leads to oxidative stress and protein glycation. In contrast, many studies have shown that domestic and wild birds are relatively resistant to these glucose-mediated pathologies. Surprisingly very little research has examined protein glycation in birds of prey, which by nature consume a diet high in protein and fat that promotes gluconeogenesis. The purpose of this study was to evaluate protein glycation and antioxidant concentrations in serum samples from several birds of prey (bald eagle (BAEA), red-tailed hawk (RTHA), barred owl (BAOW), great horned owl (GHOW)) as protein glycation can accelerate oxidative stress and vice versa. Serum glucose was measured using a commercially available assay, native albumin glycation was measured by mass spectrometry and various antioxidants (uric acid, vitamin E, retinol and several carotenoids) were measured by high performance liquid chromatography. Although glucose concentrations were not significantly different between species (p=0.340), albumin glycation was significantly higher (p=0.004) in BAEA (23.67±1.90%) and BAOW (24.28±1.43%) compared to RTHA (14.31±0.63%). Of the antioxidants examined, lutein was significantly higher in BAOW (p=0.008). BAEA had the highest beta-cryptoxanthin and beta-carotene concentrations (p<0.005). The high concentrations of antioxidants in these birds of prey relative to other birds likely helps protect from complications that may otherwise arise from having high glucose and protein glycation.
[Mh] Termos MeSH primário: Antioxidantes/metabolismo
Proteínas Aviárias/sangue
Glicemia/metabolismo
Águias/sangue
Falcões/sangue
Albumina Sérica/metabolismo
Estrigiformes/sangue
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
beta-Criptoxantina/sangue
Glicosilação
Luteína/sangue
Comportamento Predatório/fisiologia
Alinhamento de Sequência
Homologia de Sequência de Aminoácidos
Ácido Úrico/sangue
Vitamina A/sangue
Vitamina E/sangue
beta Caroteno/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Avian Proteins); 0 (Beta-Cryptoxanthin); 0 (Blood Glucose); 0 (Serum Albumin); 01YAE03M7J (beta Carotene); 11103-57-4 (Vitamin A); 1406-18-4 (Vitamin E); 268B43MJ25 (Uric Acid); X72A60C9MT (Lutein)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170523
[St] Status:MEDLINE


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[PMID]:28447196
[Au] Autor:Malapati H; Millen SM; J Buchser W
[Ad] Endereço:Department of Biology, College of William & Mary, 540 Landrum Dr., Williamsburg, VA, USA.
[Ti] Título:The axon degeneration gene SARM1 is evolutionarily distinct from other TIR domain-containing proteins.
[So] Source:Mol Genet Genomics;292(4):909-922, 2017 Aug.
[Is] ISSN:1617-4623
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Many forms of neurodegenerative disease are characterized by Wallerian degeneration, an active program of axonal destruction. Recently, the important player which enacts Wallerian degeneration was discovered, the multidomain protein SARM1. Since the SARM1 protein has classically been thought of as an innate immune molecule, its role in Wallerian degeneration has raised questions on the evolutionary forces acting on it. Here, we synthesize a picture of SARM1's evolution through various organisms by examining the molecular and genetic changes of SARM1 and the genes around it. Using proteins that possess domains homologous to SARM1, we established distances and Ka/Ks values through 5671 pairwise species-species comparisons. We demonstrate that SARM1 diverged across species in a pattern similar to other SAM domain-containing proteins. This is surprising, because it was expected that SARM1 would behave more like its TIR domain relatives. Going along with this divorce from TIR, we also noted that SARM1's TIR is under stronger purifying selection than the rest of the TIR domain-containing proteins (remaining highly conserved). In addition, SARM1's synteny analysis reveals that the surrounding gene cluster is highly conserved, functioning as a potential nexus of gene functionality across species. Taken together, SARM1 demonstrates a unique evolutionary pattern, separate from the TIR domain protein family.
[Mh] Termos MeSH primário: Proteínas do Domínio Armadillo/genética
Proteínas do Citoesqueleto/genética
Águias/genética
Esocidae/genética
Cavalos/genética
Degeneração Walleriana/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos/genética
Animais
Axônios/patologia
Composição de Bases/genética
Evolução Biológica
Bases de Dados Genéticas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Armadillo Domain Proteins); 0 (Cytoskeletal Proteins)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170803
[Lr] Data última revisão:
170803
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1007/s00438-017-1320-6


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[PMID]:28403159
[Au] Autor:Sur M; Suffredini T; Wessells SM; Bloom PH; Lanzone M; Blackshire S; Sridhar S; Katzner T
[Ad] Endereço:Department of Biological Sciences, Boise State University, Boise, Idaho, United States of America.
[Ti] Título:Improved supervised classification of accelerometry data to distinguish behaviors of soaring birds.
[So] Source:PLoS One;12(4):e0174785, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Soaring birds can balance the energetic costs of movement by switching between flapping, soaring and gliding flight. Accelerometers can allow quantification of flight behavior and thus a context to interpret these energetic costs. However, models to interpret accelerometry data are still being developed, rarely trained with supervised datasets, and difficult to apply. We collected accelerometry data at 140Hz from a trained golden eagle (Aquila chrysaetos) whose flight we recorded with video that we used to characterize behavior. We applied two forms of supervised classifications, random forest (RF) models and K-nearest neighbor (KNN) models. The KNN model was substantially easier to implement than the RF approach but both were highly accurate in classifying basic behaviors such as flapping (85.5% and 83.6% accurate, respectively), soaring (92.8% and 87.6%) and sitting (84.1% and 88.9%) with overall accuracies of 86.6% and 92.3% respectively. More detailed classification schemes, with specific behaviors such as banking and straight flights were well classified only by the KNN model (91.24% accurate; RF = 61.64% accurate). The RF model maintained its accuracy of classifying basic behavior classification accuracy of basic behaviors at sampling frequencies as low as 10Hz, the KNN at sampling frequencies as low as 20Hz. Classification of accelerometer data collected from free ranging birds demonstrated a strong dependence of predicted behavior on the type of classification model used. Our analyses demonstrate the consequence of different approaches to classification of accelerometry data, the potential to optimize classification algorithms with validated flight behaviors to improve classification accuracy, ideal sampling frequencies for different classification algorithms, and a number of ways to improve commonly used analytical techniques and best practices for classification of accelerometry data.
[Mh] Termos MeSH primário: Águias
Voo Animal
[Mh] Termos MeSH secundário: Acelerometria
Algoritmos
Animais
Comportamento Animal
Aprendizado de Máquina
Modelos Biológicos
Modelos Estatísticos
Gravação em Vídeo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170504
[Lr] Data última revisão:
170504
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0174785


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[PMID]:28306744
[Au] Autor:van Eeden R; Whitfield DP; Botha A; Amar A
[Ad] Endereço:DST-NRF Centre of Excellence Percy FitzPatrick Institute of African Ornithology, Department of Biological Sciences, University of Cape Town, Cape Town, South Africa.
[Ti] Título:Ranging behaviour and habitat preferences of the Martial Eagle: Implications for the conservation of a declining apex predator.
[So] Source:PLoS One;12(3):e0173956, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Understanding the ranging behaviours of species can be helpful in effective conservation planning. However, for many species that are rare, occur at low densities, or occupy challenging environments, this information is often lacking. The Martial Eagle (Polemaetus bellicosus) is a low density apex predator declining in both non-protected and protected areas in southern Africa, and little is known about its ranging behaviour. We use GPS tags fitted to Martial Eagles (n = 8) in Kruger National Park (KNP), South Africa to describe their ranging behaviour and habitat preference. This represents the first time that such movements have been quantified in adult Martial Eagles. Territorial eagles (n = 6) held home ranges averaging ca. 108 km2. Home range estimates were similar to expectations based on inter-nest distances, and these large home range sizes could constrain the carrying capacity of even the largest conservation areas. Two tagged individuals classed as adults on plumage apparently did not hold a territory, and accordingly ranged more widely (ca. 44,000 km2), and beyond KNP boundaries as floaters. Another two territorial individuals abandoned their territories and joined the 'floater' population, and so ranged widely after leaving their territories. These unexpected movements after territory abandonment could indicate underlying environmental degradation. Relatively high mortality of these wide-ranging 'floaters' due to anthropogenic causes (three of four) raises further concerns for the species' persistence. Habitat preference models suggested Martial Eagles used areas preferentially that were closer to rivers, had higher tree cover, and were classed as dense bush rather than open bush or grassland. These results can be used by conservation managers to help guide actions to preserve breeding Martial Eagles at an appropriate spatial scale.
[Mh] Termos MeSH primário: Conservação dos Recursos Naturais
Águias/fisiologia
Ecossistema
[Mh] Termos MeSH secundário: Animais
Sistemas de Informação Geográfica
África do Sul
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170318
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0173956


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[PMID]:28183111
[Au] Autor:Lerner H; Christidis L; Gamauf A; Griffiths C; Haring E; Huddleston CJ; Kabra S; Kocum A; Krosby M; Kvaløy K; Mindell D; Rasmussen P; Røv N; Wadleigh R; Wink M; Gjershaug JO
[Ad] Endereço:Joseph Moore Museum, Earlham College, 801 National Road West, Richmond IN 47374 USA.. hlerner@gmail.com.
[Ti] Título:Phylogeny and new taxonomy of the Booted Eagles (Accipitriformes: Aquilinae).
[So] Source:Zootaxa;4216(4):zootaxa.4216.4.1, 2017 Jan 09.
[Is] ISSN:1175-5334
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:We present a phylogeny of all booted eagles (38 extant and one extinct species) based on analysis of published sequences from seven loci. We find molecular support for five major clades within the booted eagles: Nisaetus (10 species), Spizaetus (4 species), Clanga (3 species), Hieraaetus (6 species) and Aquila (11 species), requiring generic changes for 14 taxa. Additionally, we recommend that the Long-crested Eagle (Lophaetus occipitalis) and the Black Eagle (Ictinaetus malaiensis) remain in their monotypic genera, due to their distinctive morphology. We apply the recently resurrected genus Clanga for the spotted eagles (previously Aquila spp.) to resolve the paraphyly of the genus Aquila such that the clade including the Booted Eagle (H. pennatus), Little Eagle (H. morphnoides), Pygmy Eagle (H. weiskei), Ayres's Eagle (H. ayresii) and Wahlberg's Eagle (H. wahlbergi) can remain in the genus Hieraaetus. The Rufous-bellied Eagle should be retained in the genus Lophotriorchis. For consistency in English names, we recommend that the term "hawk-eagles" be used only for the species in the genera Nisaetus and Spizaetus. We suggest following new or modified English names: Cassin's Eagle (Aquila africana), Bonaparte's Eagle (A. spilogaster), Ayres's Eagle (Hieraaetus ayresii), and Black-and-chestnut Hawk-Eagle (Spizaetus isidori).
[Mh] Termos MeSH primário: Águias/classificação
Filogenia
[Mh] Termos MeSH secundário: Distribuição Animal
Animais
Águias/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170508
[Lr] Data última revisão:
170508
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170210
[St] Status:MEDLINE
[do] DOI:10.11646/zootaxa.4216.4.1


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[PMID]:28180973
[Au] Autor:Adams DB; Williams SM
[Ad] Endereço:Department of Anthropology, 4005 Smith Laboratory, The Ohio State University, 174 W. 18th Ave., Columbus, OH, 43210, USA. adams.1238@osu.edu.
[Ti] Título:Fatal attack on a Rylands' bald-faced saki monkey (Pithecia rylandsi) by a black-and-white hawk-eagle (Spizaetus melanoleucus).
[So] Source:Primates;58(2):361-365, 2017 Apr.
[Is] ISSN:1610-7365
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Predation risk has played an important role in primate behavioral evolution, yet natural primate-predator interactions are rarely observed. We describe the consumption and probable predation of an adult bald-faced saki monkey (Pithecia rylandsi) by a black-and-white hawk-eagle (Spizaetus melanoleucus) at the Los Amigos Biological Station in lowland Amazonian Peru. To our knowledge, this is the first published case of a black-and-white hawk-eagle consuming any primate species. We contend that while most reported observations of successful and attempted predation by raptors involves the largest and most notorious species (i.e. the harpy eagle), smaller and lesser known species like S. melanoleucus should be considered more seriously as a predator of neotropical primates. We discuss the predation event in the context of understanding what other neotropical primates might be vulnerable to S. melanoleucus predation given its body size and hunting tactic.
[Mh] Termos MeSH primário: Águias/fisiologia
Cadeia Alimentar
Pitheciidae/fisiologia
Comportamento Predatório
[Mh] Termos MeSH secundário: Animais
Feminino
Masculino
Peru
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171014
[Lr] Data última revisão:
171014
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170210
[St] Status:MEDLINE
[do] DOI:10.1007/s10329-017-0598-7


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[PMID]:27485747
[Au] Autor:Suscke P; Verderane M; de Oliveira RS; Delval I; Fernández-Bolaños M; Izar P
[Ad] Endereço:Department of Experimental Psychology, Institute of Psychology, University of São Paulo, Av. Prof. Mello Moraes 1721, São Paulo, SP, CEP 05508-020, Brazil. psuscke@hotmail.com.
[Ti] Título:Predatory threat of harpy eagles for yellow-breasted capuchin monkeys in the Atlantic Forest.
[So] Source:Primates;58(1):141-147, 2017 Jan.
[Is] ISSN:1610-7365
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:We describe seven encounters between different harpy eagle individuals (Harpia harpyja) and a group of yellow-breasted capuchin monkeys (Sapajus xanthosternos) in Una Biological Reserve. These interactions lasted 58 min on average. In each of those encounters, the capuchin monkeys used particular behavioral strategies against the harpy eagle that were not employed in reaction to other aerial predators. We did not observe any successful predation events, but after one of those encounters an infant disappeared from the capuchin group. As a whole, these observations indicate that the presence of harpy eagles in the group's home range increases predation risk for capuchin monkeys. The present report also suggests a reoccupation by H. harpyja of this area, as no previous recent records identify harpy eagle occurrence in Una Biological Reserve.
[Mh] Termos MeSH primário: Cebinae/fisiologia
Águias/fisiologia
Cadeia Alimentar
Atividade Motora
Comportamento Predatório
[Mh] Termos MeSH secundário: Animais
Brasil
Feminino
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171014
[Lr] Data última revisão:
171014
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160804
[St] Status:MEDLINE
[do] DOI:10.1007/s10329-016-0557-8


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[PMID]:28107076
[Au] Autor:Stephen AA; Leone AM; Toplon DE; Archer LL; Wellehan JF
[Ti] Título:Characterization of an Avipoxvirus From a Bald Eagle ( Haliaeetus leucocephalus ) Using Novel Consensus PCR Protocols for the rpo147 and DNA-Dependent DNA Polymerase Genes.
[So] Source:J Avian Med Surg;30(4):378-385, 2016 Dec.
[Is] ISSN:1082-6742
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A juvenile female bald eagle ( Haliaeetus leucocephalus ) was presented with emaciation and proliferative periocular lesions. The eagle did not respond to supportive therapy and was euthanatized. Histopathologic examination of the skin lesions revealed plaques of marked epidermal hyperplasia parakeratosis, marked acanthosis and spongiosis, and eosinophilic intracytoplasmic inclusion bodies. Novel polymerase chain reaction (PCR) assays were done to amplify and sequence DNA polymerase and rpo147 genes. The 4b gene was also analyzed by a previously developed assay. Bayesian and maximum likelihood phylogenetic analyses of the obtained sequences found it to be poxvirus of the genus Avipoxvirus and clustered with other raptor isolates. Better phylogenetic resolution was found in rpo147 rather than the commonly used DNA polymerase. The novel consensus rpo147 PCR assay will create more accurate phylogenic trees and allow better insight into poxvirus history.
[Mh] Termos MeSH primário: Avipoxvirus/isolamento & purificação
Doenças das Aves/virologia
Águias
Reação em Cadeia da Polimerase/veterinária
Infecções por Poxviridae/veterinária
Proteínas Virais/metabolismo
[Mh] Termos MeSH secundário: Animais
Animais Selvagens
Doenças das Aves/diagnóstico
DNA Polimerase Dirigida por DNA/genética
DNA Polimerase Dirigida por DNA/metabolismo
Feminino
Regulação Enzimológica da Expressão Gênica/fisiologia
Regulação Viral da Expressão Gênica/fisiologia
Filogenia
Reação em Cadeia da Polimerase/métodos
Infecções por Poxviridae/diagnóstico
Infecções por Poxviridae/virologia
Proteínas Virais/genética
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Viral Proteins); EC 2.7.7.7 (DNA-Directed DNA Polymerase)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE
[do] DOI:10.1647/2015-120


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[PMID]:28107073
[Au] Autor:Eid R; Guzman DS; Keller KA; Wiggans KT; Murphy CJ; LaDouceur EE; Keel MK; Reilly CM
[Ti] Título:Choroidal Vasculopathy and Retinal Detachment in a Bald Eagle ( Haliaeetus leucocephalus ) With Lead Toxicosis.
[So] Source:J Avian Med Surg;30(4):357-363, 2016 Dec.
[Is] ISSN:1082-6742
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A subadult male bald eagle ( Haliaeetus leucocephalus ) was presented for severe depression and weakness. Physical examination findings included depressed mentation, dehydration, sternal recumbency, poor body condition, and bilateral, whole-head, horizontal nystagmus. A heavy-metal panel was performed, and blood lead levels were 6.1 ppm. Treatment for lead poisoning was initiated, including subcutaneous fluids and parenteral calcium-disodium ethylenediaminetetraacetic acid, ceftiofur, and meloxicam. Ophthalmic examination findings included absent menace response, absent dazzle reflex, slow and incomplete direct pupillary light reflex, mild anterior uveitis, incipient cataracts, multifocal retinal tears, and retinal separation in both eyes. Because of poor prognosis for vision and release to the wild, the eagle was euthanatized. No lesions were observed on gross postmortem examination. Histologically, extensive myocardial necrosis and multisystemic arteriolar vasculopathy were identified. The eyes were examined after tissue processing, and the vasculopathy extended into the choriocapillaris and was associated with a secondary, bilateral, exudative, retinal detachment. This is the first report in avian species characterizing the histopathologic ocular lesions of lead poisoning.
[Mh] Termos MeSH primário: Doenças das Aves/etiologia
Doenças da Coroide/veterinária
Águias
Intoxicação por Chumbo/veterinária
Chumbo/toxicidade
Descolamento Retiniano/veterinária
[Mh] Termos MeSH secundário: Animais
Doenças das Aves/patologia
Doenças da Coroide/etiologia
Intoxicação por Chumbo/complicações
Intoxicação por Chumbo/patologia
Masculino
Descolamento Retiniano/etiologia
Descolamento Retiniano/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
2P299V784P (Lead)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE
[do] DOI:10.1647/2015122



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