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  1 / 5217 MEDLINE  
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[PMID]:28792422
[Au] Autor:Sood N; Swaminathan TR; Yadav MK; Pradhan PK; Kumar R; Sood NK
[Ad] Endereço:ICAR-National Bureau of Fish Genetic Resources, Canal Ring Road, PO Dilkusha, Lucknow, Uttar Pradesh 226002, India.
[Ti] Título:First report of cutaneous infiltrative lipoma in goldfish Carassius auratus.
[So] Source:Dis Aquat Organ;125(3):243-247, 2017 08 09.
[Is] ISSN:0177-5103
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Goldfish Carassius auratus is the most popular ornamental species, widely present in private and public aquaria. In the present case, 2 goldfish exhibited bilateral, multiple, variably sized, round, pale-white, soft, protruding masses on the body. The microscopic examination of the masses revealed well-differentiated adipocytes infiltrating the subcutaneous skeletal muscle bundles. The histological lesions were consistent with infiltrative lipoma. To our knowledge, this is the first report of cutaneous infiltrative lipoma in goldfish.
[Mh] Termos MeSH primário: Doenças dos Peixes/patologia
Carpa Dourada
Lipoma/veterinária
Neoplasias Cutâneas/veterinária
[Mh] Termos MeSH secundário: Animais
Lipoma/patologia
Neoplasias Cutâneas/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170810
[St] Status:MEDLINE
[do] DOI:10.3354/dao03148


  2 / 5217 MEDLINE  
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[PMID]:28651981
[Au] Autor:Hu Y; Liu L; Liu GL; Tu X; Wang GX; Ling F
[Ad] Endereço:College of Animal Science and Technology, Northwest A&F University, Xinong Road 22nd, Yangling, Shaanxi 712100, China.
[Ti] Título:Synthesis and anthelmintic activity of arctigenin derivatives against Dactylogyrus intermedius in goldfish.
[So] Source:Bioorg Med Chem Lett;27(15):3310-3316, 2017 08 01.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:To control the parasitic disease of Dactylogyrus intermedius, a series of new arctigenin derivatives were designed, synthesized and tested in our study. The anthelmintic activity of most of the derivatives ranged from 1 to 10mg/L. Compared to traditional drug praziquantel (EC =2.69mg/L), ether derivatives 2g and 2h exhibited slightly higher anti-parasitic activity, with the EC values of 2.48 and 1.52mg/L, respectively. Furthermore, the arctigenin-imidazole hybrids 4a and 4b also removed D. intermedius effectively, with the EC values of 2.13 and 2.07mg/L, respectively. The structure-activity relationship analysis indicated that four carbon atoms length of linker and imidazole substitute group could significantly increase the anthelmintic activity, and reduced the toxicity. Through the scanning electron microscope observation, compounds 4a and 4b caused the D. intermedius tegumental damage such as intensive wrinkles, holes and nodular structures. Overall, the structural optimization analysis of arctigenin suggested that 4a and 4b can be used for preventing and controlling Dactylogyrus infections and considered as promising lead compounds for the development of commercial drugs.
[Mh] Termos MeSH primário: Anti-Helmínticos/química
Anti-Helmínticos/farmacologia
Doenças dos Peixes/tratamento farmacológico
Furanos/química
Furanos/farmacologia
Carpa Dourada/parasitologia
Helmintíase Animal/tratamento farmacológico
Lignanas/química
Lignanas/farmacologia
Platelmintos/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Anti-Helmínticos/síntese química
Furanos/síntese química
Lignanas/síntese química
Drogas Veterinárias/síntese química
Drogas Veterinárias/química
Drogas Veterinárias/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anthelmintics); 0 (Furans); 0 (Lignans); 0 (Veterinary Drugs); U76MR9VS6M (arctigenin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE


  3 / 5217 MEDLINE  
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[PMID]:28627487
[Au] Autor:Molnár K; Székely C
[Ad] Endereço:Institute for Veterinary Medical Research, Centre for Agricultural Research, HAS, POB 18, 1581 Budapest, Hungary.
[Ti] Título:Epicellular coccidiosis in goldfish.
[So] Source:Dis Aquat Organ;125(1):1-5, 2017 06 19.
[Is] ISSN:0177-5103
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:In a goldfish stock held in a pet fish pond, heavy coccidian infection, caused by an epicellularly developing Goussia species, appeared in April of 3 consecutive years (2014 to 2016). The shape and size of the oocysts resembled those of an inadequately described species, Goussia carassiusaurati (Romero-Rodriguez, 1978). In histological sections, gamogonic and sporogonic stages infested mostly the second fifth of the intestine, where almost all epithelial cells were infected. Both gamonts and young oocysts occurred intracellularly but in an extracytoplasmal position, seemingly outside the cells. Oocysts were shed non-sporulated. Spheroid to ellipsoidal non-sporulated oocysts measured 12.4 × 13.5 µm on average, but after 48 h sporulation in tap water they reached a size of 16 × 13 µm. The 4 elliptical sporocysts located loosely within the sporulated oocysts measured 13 × 5.4 µm. The oocysts and sporocysts were smaller than those of the better-known Goussia species G. aurati (Hoffman, 1965).
[Mh] Termos MeSH primário: Coccidiose/veterinária
Doenças dos Peixes/parasitologia
Carpa Dourada
[Mh] Termos MeSH secundário: Animais
Coccidiose/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE
[do] DOI:10.3354/dao03127


  4 / 5217 MEDLINE  
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[PMID]:28614698
[Au] Autor:Kase Y; Ikari T; Sekiguchi T; Sato M; Ogiso S; Kawada T; Matsubara S; Satake H; Sasayama Y; Endo M; Kitamura KI; Hattori A; Watanabe TX; Maruyama Y; Watanabe Y; Funahashi H; Kambegawa A; Suzuki N
[Ad] Endereço:Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Noto-cho, Ishikawa 927-0553, Japan.
[Ti] Título:Sardine procalcitonin amino-terminal cleavage peptide has a different action from calcitonin and promotes osteoblastic activity in the scales of goldfish.
[So] Source:Comp Biochem Physiol A Mol Integr Physiol;211:77-83, 2017 Sep.
[Is] ISSN:1531-4332
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The nucleotide sequence of a sardine preprocalcitonin precursor has been determined from their ultimobranchial glands in the present study. From our analysis of this sequence, we found that sardine procalcitonin was composed of procalcitonin amino-terminal cleavage peptide (N-proCT) (53 amino acids), CT (32 amino acids), and procalcitonin carboxyl-terminal cleavage peptide (C-proCT) (18 amino acids). As compared with C-proCT, N-proCT has been highly conserved among teleosts, reptiles, and birds, which suggests that N-proCT has some bioactivities. Therefore, both sardine N-proCT and sardine CT were synthesized, and their bioactivities for osteoblasts and osteoclasts were examined using our assay system with goldfish scales that consisted of osteoblasts and osteoclasts. As a result, sardine N-proCT (10 M) activated osteoblastic marker enzyme activity, while sardine CT did not change. On the other hand, sardine CT (10 to 10 M) suppressed osteoclastic marker enzyme activity, although sardine N-proCT did not influence enzyme activity. Furthermore, the mRNA expressions of osteoblastic markers such as type 1 collagen and osteocalcin were also promoted by sardine N-proCT (10 M) treatment; however, sardine CT did not influence their expressions. The osteoblastic effects of N-proCT lack agreement. In the present study, we can evaluate exactly the action for osteoblasts because our scale assay system is very sensitive and it is a co-culture system for osteoblasts and osteoclasts with calcified bone matrix. Both CT and N-proCT seem to influence osteoblasts and osteoclasts and promote bone formation by different actions in teleosts.
[Mh] Termos MeSH primário: Calcitonina/análogos & derivados
Calcitonina/farmacologia
Osteoblastos/efeitos dos fármacos
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Sequência de Bases
Calcitonina/genética
Carpa Dourada
Filogenia
Homologia de Sequência de Aminoácidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (calcitonin, sardine); 9007-12-9 (Calcitonin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE


  5 / 5217 MEDLINE  
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[PMID]:28528318
[Au] Autor:Li MH; Ruan LY; Zhou JW; Fu YH; Jiang L; Zhao H; Wang JS
[Ad] Endereço:Center for Molecular Metabolism, School of Environmental and Biological Engineering, Nanjing University of Science & Technology, 200 Xiao Ling Wei Street, Nanjing 210094, People's Republic of China.
[Ti] Título:Metabolic profiling of goldfish (Carassius auratis) after long-term glyphosate-based herbicide exposure.
[So] Source:Aquat Toxicol;188:159-169, 2017 Jul.
[Is] ISSN:1879-1514
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Glyphosate is an efficient herbicide widely used worldwide. However, its toxicity to non-targeted organisms has not been fully elucidated. In this study, the toxicity of glyphosate-based herbicide was evaluated on goldfish (Carassius auratus) after long-term exposure. Tissues of brains, kidneys and livers were collected and submitted to NMR-based metabolomics analysis and histopathological inspection. Plasma was collected and the blood biochemical indexes of AST, ALT, BUN, CRE, LDH, SOD, GSH-Px, GR and MDA were measured. Long-term glyphosate exposure caused disorders of blood biochemical indexes and renal tissue injury in goldfish. Metabolomics analysis combined with correlation network analysis uncovered significant perturbations in oxidative stress, energy metabolism, amino acids metabolism and nucleosides metabolism in glyphosate dosed fish, which provide new clues to the toxicity of glyphosate. This integrated metabolomics approach showed its applicability in discovering the toxic mechanisms of pesticides, which provided new strategy for the assessment of the environmental risk of herbicides to non-target organisms.
[Mh] Termos MeSH primário: Glicina/análogos & derivados
Carpa Dourada/metabolismo
Herbicidas/toxicidade
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Encéfalo/metabolismo
Metabolismo Energético/efeitos dos fármacos
Glicina/toxicidade
Rim/metabolismo
Fígado/metabolismo
Espectroscopia de Ressonância Magnética
Masculino
Metabolômica
Estresse Oxidativo/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Herbicides); 0 (Water Pollutants, Chemical); 4632WW1X5A (glyphosate); TE7660XO1C (Glycine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170522
[St] Status:MEDLINE


  6 / 5217 MEDLINE  
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[PMID]:28433562
[Au] Autor:Feng Y; Feng HL; Fang YH; Su YB
[Ad] Endereço:School of Urban Construction, Yangtze University, Jingzhou 434023, Hubei, PR China. Electronic address: 785609881@qq.com.
[Ti] Título:Characterization of the complete mitochondrial genome of Khawia sinensis belongs among platyhelminths, cestodes.
[So] Source:Exp Parasitol;177:35-39, 2017 Jun.
[Is] ISSN:1090-2449
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Khawia sinensis is an important species in freshwater fish causing considerable economic losses to the breeding industry. This is the first mt genome of a caryophyllidean cestode characterised. The entire mt genome of K. sinensis is 13,759 bp in length. This mt genome contains 12 protein-coding genes, 22 transfer RNA genes, two ribosomal RNA genes and two non-coding regions. The arrangement of the K. sinensis mt genome is the same as other tapeworms, however, the incomplete stop codon (A) is more frequent that other species. Phylogenetic analyses based on concatenated amino-acid sequences of the 12 protein-coding genes of 17 tapeworms including K. sinensis were conducted to assess the relationship of K. sinensis with other species, the result indicated K. sinensis was closely related with cestode species. This complete mt genome of K. sinensis will enrich the mitochondrial genome databases of tapeworms and provide important molecular markers for ecology, diagnostics, population variation and evolution of K. sinensis and other species.
[Mh] Termos MeSH primário: Cestoides/classificação
Cestoides/genética
Genoma Helmíntico
Genoma Mitocondrial
[Mh] Termos MeSH secundário: Animais
Infecções por Cestoides/parasitologia
Infecções por Cestoides/veterinária
China
Doenças dos Peixes/parasitologia
Água Doce
Genes de RNAr/genética
Carpa Dourada/parasitologia
Proteínas de Helminto/genética
Intestinos/parasitologia
Filogenia
RNA de Transferência/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Helminth Proteins); 9014-25-9 (RNA, Transfer)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170620
[Lr] Data última revisão:
170620
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170424
[St] Status:MEDLINE


  7 / 5217 MEDLINE  
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[PMID]:28413199
[Au] Autor:Matsumoto A; Tachibana M
[Ad] Endereço:Department of Psychology, Graduate School of Humanities and Sociology, The University of Tokyo.
[Ti] Título:Rapid and coordinated processing of global motion images by local clusters of retinal ganglion cells.
[So] Source:Proc Jpn Acad Ser B Phys Biol Sci;93(4):234-249, 2017.
[Is] ISSN:1349-2896
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Even when the body is stationary, the whole retinal image is always in motion by fixational eye movements and saccades that move the eye between fixation points. Accumulating evidence indicates that the brain is equipped with specific mechanisms for compensating for the global motion induced by these eye movements. However, it is not yet fully understood how the retina processes global motion images during eye movements. Here we show that global motion images evoke novel coordinated firing in retinal ganglion cells (GCs). We simultaneously recorded the firing of GCs in the goldfish isolated retina using a multi-electrode array, and classified each GC based on the temporal profile of its receptive field (RF). A moving target that accompanied the global motion (simulating a saccade following a period of fixational eye movements) modulated the RF properties and evoked synchronized and correlated firing among local clusters of the specific GCs. Our findings provide a novel concept for retinal information processing during eye movements.
[Mh] Termos MeSH primário: Fixação Ocular
Células Ganglionares da Retina/citologia
Movimentos Sacádicos
[Mh] Termos MeSH secundário: Animais
Carpa Dourada
Análise Espaço-Temporal
Transmissão Sináptica
Fatores de Tempo
Ácido gama-Aminobutírico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
56-12-2 (gamma-Aminobutyric Acid)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170810
[Lr] Data última revisão:
170810
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170418
[St] Status:MEDLINE
[do] DOI:10.2183/pjab.93.015


  8 / 5217 MEDLINE  
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[PMID]:28403143
[Au] Autor:Howlett MH; Smith RG; Kamermans M
[Ad] Endereço:Retinal Signal Processing lab, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands.
[Ti] Título:A novel mechanism of cone photoreceptor adaptation.
[So] Source:PLoS Biol;15(4):e2001210, 2017 Apr.
[Is] ISSN:1545-7885
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An animal's ability to survive depends on its sensory systems being able to adapt to a wide range of environmental conditions, by maximizing the information extracted and reducing the noise transmitted. The visual system does this by adapting to luminance and contrast. While luminance adaptation can begin at the retinal photoreceptors, contrast adaptation has been shown to start at later stages in the retina. Photoreceptors adapt to changes in luminance over multiple time scales ranging from tens of milliseconds to minutes, with the adaptive changes arising from processes within the phototransduction cascade. Here we show a new form of adaptation in cones that is independent of the phototransduction process. Rather, it is mediated by voltage-gated ion channels in the cone membrane and acts by changing the frequency response of cones such that their responses speed up as the membrane potential modulation depth increases and slow down as the membrane potential modulation depth decreases. This mechanism is effectively activated by high-contrast stimuli dominated by low frequencies such as natural stimuli. However, the more generally used Gaussian white noise stimuli were not effective since they did not modulate the cone membrane potential to the same extent. This new adaptive process had a time constant of less than a second. A critical component of the underlying mechanism is the hyperpolarization-activated current, Ih, as pharmacologically blocking it prevented the long- and mid- wavelength sensitive cone photoreceptors (L- and M-cones) from adapting. Consistent with this, short- wavelength sensitive cone photoreceptors (S-cones) did not show the adaptive response, and we found they also lacked a prominent Ih. The adaptive filtering mechanism identified here improves the information flow by removing higher-frequency noise during lower signal-to-noise ratio conditions, as occurs when contrast levels are low. Although this new adaptive mechanism can be driven by contrast, it is not a contrast adaptation mechanism in its strictest sense, as will be argued in the Discussion.
[Mh] Termos MeSH primário: Adaptação Ocular
Células Fotorreceptoras Retinianas Cones/fisiologia
[Mh] Termos MeSH secundário: Potenciais de Ação
Animais
Carpa Dourada
Cinética
Células Fotorreceptoras Retinianas Cones/efeitos da radiação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pbio.2001210


  9 / 5217 MEDLINE  
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[PMID]:28363074
[Au] Autor:Balko JA; Wilson SK; Lewbart GA; Gaines BR; Posner LP
[Ti] Título:PROPOFOL AS AN IMMERSION ANESTHETIC AND IN A MINIMUM ANESTHETIC CONCENTRATION (MAC) REDUCTION MODEL IN GOLDFISH (CARASSIUS AURATUS).
[So] Source:J Zoo Wildl Med;48(1):48-54, 2017 Mar.
[Is] ISSN:1042-7260
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Propofol is a novel immersion anesthetic in goldfish ( Carassius auratus ). Objectives were to characterize propofol as an anesthetic and assess its suitability in a minimum anesthetic concentration (MAC) reduction model. Using a crossover design, eight goldfish were submerged in 1, 5, or 10 mg/L propofol. Data included induction time, recovery time, heart rate, opercular rate, and response to supramaximal stimulation. Baseline MAC (Dixon's up-and-down method) was determined, and 15 fish were anesthetized with propofol on 4 consecutive days with MAC determination on the fifth day, weekly, for 1 mo. Using a crossover design, MAC of propofol (n = 15) was determined 1 hr following administration of i.m. butorphanol 0.05, 0.5, and 1 mg/kg, dexmedetomidine 0.01, 0.02, and 0.04 mg/kg, ketoprofen 0.5, 1, and 2 mg/kg, morphine 5, 10, and 15 mg/kg, or saline 1 ml/kg. Comparisons were performed with Wilcoxon signed-rank tests (P < 0.05) and Tango's score confidence interval. Propofol at 1 mg/L did not produce anesthesia. Induction time with 10 mg/L (112, 84-166 s) was faster than 5 mg/L (233, 150-289 s; P = 0.0078). Heart and opercular rates for 5 and 10 mg/L were 36 (24-72) beats/min, 58 (44-68) operculations/min and 39 (20-48) beats/min, 57 (48-80) operculations/min, respectively. Recovery time was 249 (143-396) s and 299 (117-886) s with 5 and 10 mg/L, respectively. Response to supramaximal stimulation was not significantly different with 5 mg/L (1/8) compared with 10 mg/L (0/8). Baseline and weekly MAC following daily exposure was 8.4 and 9.0, 8.1, 8.1, and 8.7 mg/L, respectively. MAC reduction was no more than 8% following any drug or dosage. Propofol at 5 and 10 mg/L produced anesthesia, and anesthetic needs were similar following repeated exposure. Propofol was not suitable to test MAC reduction in goldfish in this study.
[Mh] Termos MeSH primário: Anestesia/veterinária
Carpa Dourada
Hipnóticos e Sedativos/farmacologia
Propofol/farmacologia
[Mh] Termos MeSH secundário: Anestesia/métodos
Animais
Relação Dose-Resposta a Droga
Esquema de Medicação
Hipnóticos e Sedativos/administração & dosagem
Hipnóticos e Sedativos/sangue
Hipnóticos e Sedativos/farmacocinética
Propofol/administração & dosagem
Propofol/sangue
Propofol/farmacocinética
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hypnotics and Sedatives); YI7VU623SF (Propofol)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE
[do] DOI:10.1638/2016-0079.1


  10 / 5217 MEDLINE  
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[PMID]:28359089
[Au] Autor:Ma A; He M; Bai J; Wong MK; Ko WK; Wong AO
[Ad] Endereço:School of Biological Sciences, University of Hong Kong, Hong Kong HKSAR, China.
[Ti] Título:Dual Role of Insulin in Spexin Regulation: Functional Link Between Food Intake and Spexin Expression in a Fish Model.
[So] Source:Endocrinology;158(3):560-577, 2017 Mar 01.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Spexin (SPX), a neuropeptide discovered by the bioinformatics approach, has been recently identified as a satiety factor in a fish model. However, the functional link between feeding and SPX expression as well as the signal transduction for SPX regulation are totally unknown. In this study, we used goldfish as a model to examine the functional role of insulin as a postprandial signal for SPX regulation in bony fish. In goldfish, feeding could elevate plasma levels of glucose, insulin, and SPX with concurrent rises in insulin and SPX messenger RNA (mRNA) expression in the liver. Similar elevation in SPX mRNA level was also observed in the liver and brain areas involved in appetite control in goldfish after intraperitoneal injection of glucose and insulin, respectively. In parallel experiments with goldfish hepatocytes and brain cell culture, insulin signal induced by glucose was shown to exert a dual role in SPX regulation, namely (1) acting as an autocrine/paracrine signal to trigger SPX mRNA expression in the liver and (2) serving as an endocrine signal to induce SPX gene expression in the brain. Apparently, the peripheral (in the liver) and central actions of insulin (in the brain) on SPX gene expression were mediated by insulin receptor (to a lesser extent by insulin-like growth factor I receptor) coupled to mitogen-activated protein kinase kinase 3/6/p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin but not mitogen-activated protein kinase kinase 1/2/extracellular signal-regulated kinase 1/2 cascades. Our findings indicate that an insulin component inducible by glucose is present in the liver of the fish model and may serve as the postprandial signal linking food intake with SPX expression both in the central as well as at the hepatic level.
[Mh] Termos MeSH primário: Encéfalo/metabolismo
Ingestão de Alimentos/fisiologia
Insulina/sangue
Fígado/metabolismo
Hormônios Peptídicos/metabolismo
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Feminino
Carpa Dourada
Hepatócitos/metabolismo
Injeções Intraperitoneais
Sistema de Sinalização das MAP Quinases
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insulin); 0 (Peptide Hormones)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170627
[Lr] Data última revisão:
170627
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170331
[St] Status:MEDLINE
[do] DOI:10.1210/en.2016-1534



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