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[PMID]:27777046
[Au] Autor:Endsin MJ; Michalec O; Manzon LA; Lovejoy DA; Manzon RG
[Ad] Endereço:Department of Biology, University of Regina, Regina, Saskatchewan, Canada.
[Ti] Título:CRH peptide evolution occurred in three phases: Evidence from characterizing sea lamprey CRH system members.
[So] Source:Gen Comp Endocrinol;240:162-173, 2017 01 01.
[Is] ISSN:1095-6840
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The corticotropin releasing hormone (CRH) system, which includes the CRH family of peptides, their receptors (CRHRs) and a binding protein (CRHBP), has been strongly conserved throughout vertebrate evolution. The identification of invertebrate homologues suggests this system evolved over 500 million years ago. However, the early vertebrate evolution of the CRH system is not understood. Current theory indicates that agnathans (hagfishes and lampreys) are monophyletic with a conservative evolution over the past 500million years and occupy a position at the root of vertebrate phylogeny. We isolated the cDNAs for three CRH family members, two CRHRs and a CRHBP from the sea lamprey, Petromyzon marinus. Two of the CRH peptides are related to the CRH/urotensin-1 (UI) lineage, whereas the other is a urocortin (Ucn) 3 orthologue. The predicted amino acid identity of CRH and UI is 61% but they possess distinct motifs indicative of each peptide, suggesting an early divergence of the two genes. Based on our findings we propose the CRH peptides evolved in at least 3 distinct phases. The first occurring prior to the agnathans gave rise to the CRH/UI-like and Ucn2/3-like paralogous lineages. The second was a partial sub-genomic duplication of the ancestral CRH/UI-like gene, but not the Ucn2/3-like gene, giving rise to the CRH and UI (Ucn) lineages. The third event which resulted in the appearance of Ucn2 and Ucn3 must have occurred after the evolution of the cartilaginous fishes. Interestingly, unlike other vertebrate CRHRs, we were unable to classify our two P. marinus receptors (designated CRHRα and CRHRß) as either type 1 or type 2, indicating that this split evolved later in vertebrate evolution. A single CRHBP gene was found suggesting that either this gene has not been affected by the vertebrate genome duplications or there have been a series of paralogous gene deletions. This study suggests that P. marinus possess a functional CRH system that differs from that of the gnathostomes and may represent a model for the earliest functioning CRH system in vertebrates.
[Mh] Termos MeSH primário: Hormônio Liberador da Corticotropina/genética
Evolução Molecular
Petromyzon/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Análise de Variância
Animais
Hormônio Liberador da Corticotropina/química
DNA Complementar/genética
Genoma
Especificidade de Órgãos/genética
Filogenia
Ligação Proteica
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Alinhamento de Sequência
Análise de Sequência de DNA
Estresse Fisiológico/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Complementary); 0 (RNA, Messenger); 9015-71-8 (Corticotropin-Releasing Hormone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180124
[Lr] Data última revisão:
180124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


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[PMID]:28456451
[Au] Autor:Bussy U; Chung-Davidson YW; Buchinger TJ; Li K; Li W
[Ad] Endereço:Department of Fisheries and Wildlife, Michigan State University, Room 13 Natural Resources Building, 480 Wilson Road, East Lansing, MI 48824, USA.
[Ti] Título:High-sensitivity determination of estrogens in fish plasma using chemical derivatization upstream UHPLC-MSMS.
[So] Source:Steroids;123:13-19, 2017 Jul.
[Is] ISSN:1878-5867
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This article describes the development and validation of a sensitive LC-MSMS method for determination of estrogen in fish plasma. Dansyl chloride derivatization of the phenol functional group in estrogen was used to enhance the response to atmospheric pressure ionization leading to improve the sensitivity. Individual C internal standards were selected after comparison with deuterated standards. Liquid-liquid extraction (ethyl acetate or methyl tert-butyl ether) and protein precipitation (acetonitrile, methanol or acetone) were compared for the extraction and clean-up of estrogens from fish plasma. Ethyl acetate was selected as the best alternative with recovery ranging from 61 to 96% and matrix effect ranging from 88 to 106%. Limits of quantification ranged from 0.5 to 1pg/mL showing a gain in sensitivity of 10,000 times over electrospray ionization of underivatized estrogens. Accuracy and precision were validated over three consecutive days and the method was applied to measure estrogen in sea lamprey (Petromyzon marinus) and lake trout (Salvelinus namaycush) plasma. Estrone and estriol were detected in fish below 1ng/mL in plasma, justifying the need of a highly sensitive LC-MSMS quantification method.
[Mh] Termos MeSH primário: Análise Química do Sangue/métodos
Cromatografia Líquida de Alta Pressão/métodos
Estrogênios/sangue
Estrogênios/química
Petromyzon/sangue
Espectrometria de Massas em Tandem/métodos
Truta/sangue
[Mh] Termos MeSH secundário: Acetatos/química
Animais
Estrogênios/isolamento & purificação
Limite de Detecção
Éteres Metílicos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Estrogens); 0 (Methyl Ethers); 29I4YB3S89 (methyl tert-butyl ether); 76845O8NMZ (ethyl acetate)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE


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[PMID]:28634722
[Au] Autor:Li K; Scott AM; Riedy JJ; Fissette S; Middleton ZE; Li W
[Ad] Endereço:Department of Fisheries and Wildlife, Michigan State University, East Lansing, MI, 48824, USA.
[Ti] Título:Three Novel Bile Alcohols of Mature Male Sea Lamprey (Petromyzon marinus) Act as Chemical Cues for Conspecifics.
[So] Source:J Chem Ecol;43(6):543-549, 2017 Jun.
[Is] ISSN:1573-1561
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sea lamprey, Petromyzon marinus, rely heavily on chemical cues that mediate their life history events, such as migration and reproduction. Here, we describe petromyzone A-C (1-3), three novel bile alcohols that are highly oxidized and sulfated, isolated from water conditioned with spermiated male sea lamprey. Structures of these compounds were unequivocally established by spectroscopic analyses and by comparison with spectra of known compounds. Electro-olfactogram recordings showed that 1 at 10 M was stimulatory to the adult sea lamprey olfactory epithelium, while 2 and 3 were stimulatory at 10 M. Behavioral assays indicated that 1 is attractive, 2 is not attractive or repulsive, and 3 is repulsive to ovulated female sea lamprey. The results suggest that 1 and 2 may be putative pheromones that mediate chemical communication in sea lamprey. The identification of these three components enhances our understanding of the structures and functions of sex pheromone components in this species and may provide useful behavioral manipulation tools for the integrated management of sea lamprey, a destructive invader in the Laurentian Great Lakes.
[Mh] Termos MeSH primário: Colestanóis/química
Colestanóis/metabolismo
Petromyzon/fisiologia
Atrativos Sexuais/química
Atrativos Sexuais/fisiologia
[Mh] Termos MeSH secundário: Animais
Cromatografia Líquida de Alta Pressão
Cromatografia em Camada Delgada
Sinais (Psicologia)
Feminino
Masculino
Espectrometria de Massas
Estrutura Molecular
Mucosa Olfatória/fisiologia
Ovulação
Esteroides/química
Esteroides/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cholestanols); 0 (Sex Attractants); 0 (Steroids)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170801
[Lr] Data última revisão:
170801
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170622
[St] Status:MEDLINE
[do] DOI:10.1007/s10886-017-0852-x


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[PMID]:28561092
[Au] Autor:McConville MB; Cohen NM; Nowicki SM; Lantz SR; Hixson JL; Ward AS; Remucal CK
[Ad] Endereço:Environmental Chemistry and Technology Program, University of Wisconsin - Madison, Madison, Wisconsin, USA. remucal@wisc.edu.
[Ti] Título:A field analysis of lampricide photodegradation in Great Lakes tributaries.
[So] Source:Environ Sci Process Impacts;19(7):891-900, 2017 Jul 19.
[Is] ISSN:2050-7895
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The lampricides 3-trifluoromethyl-4-nitrophenol (TFM) and 2',5-dichloro-4'-nitrosalicylanilide (niclosamide) are added to Great Lakes tributaries to target the sea lamprey, an invasive parasitic fish. This study examines the photochemical behavior of the lampricides in Carpenter Creek, Sullivan Creek, and the Manistique River. The observed loss of TFM in Carpenter and Sullivan Creeks (i.e., 34 and 19%) was similar to the loss of bromide in parallel time of passage studies (i.e., 30 and 29%), demonstrating that TFM photodegradation was minimal in both tributaries during the lampricide application. Furthermore, the absence of inorganic and organic photoproducts in the Manistique River demonstrates that TFM and niclosamide photodegradation was minimal in this large tributary, despite its long residence time (i.e., 3.3 days). Kinetic modeling was used to identify environmental variables primarily responsible for the limited photodegradation of TFM in the field compared to estimates from laboratory data. This analysis demonstrates that the lack of TFM photodegradation was attributable to the short residence times in Carpenter and Sullivan Creeks, while depth, time of year, time of day, and cloud cover influenced photochemical fate in the Manistique River. The modeling approach was extended to assess how many of the 140 United States tributaries treated with lampricides in 2015 and 2016 were amenable to TFM photolysis. While >50% removal of TFM due to photolysis could occur in 13 long and shallow tributaries, in most systems lampricides will reach the Great Lakes untransformed.
[Mh] Termos MeSH primário: Niclosamida/análise
Nitrofenóis/análise
Petromyzon/crescimento & desenvolvimento
Fotólise
Rios/química
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Animais
Monitoramento Ambiental
Great Lakes Region
Espécies Introduzidas
Cinética
Niclosamida/efeitos da radiação
Nitrofenóis/efeitos da radiação
Poluentes Químicos da Água/efeitos da radiação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nitrophenols); 0 (Water Pollutants, Chemical); 8KK8CQ2K8G (Niclosamide); 96W52A3IFS (3-trifluoromethyl-4-nitrophenol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170601
[St] Status:MEDLINE
[do] DOI:10.1039/c7em00173h


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[PMID]:28321127
[Au] Autor:Green SA; Uy BR; Bronner ME
[Ad] Endereço:Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, USA.
[Ti] Título:Ancient evolutionary origin of vertebrate enteric neurons from trunk-derived neural crest.
[So] Source:Nature;544(7648):88-91, 2017 04 06.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The enteric nervous system of jawed vertebrates arises primarily from vagal neural crest cells that migrate to the foregut and subsequently colonize and innervate the entire gastrointestinal tract. Here we examine development of the enteric nervous system in the basal jawless vertebrate the sea lamprey (Petromyzon marinus) to gain insight into its evolutionary origin. Surprisingly, we find no evidence for the existence of a vagally derived enteric neural crest population in the lamprey. Rather, labelling with the lipophilic dye DiI shows that late-migrating cells, originating from the trunk neural tube and associated with nerve fibres, differentiate into neurons within the gut wall and typhlosole. We propose that these trunk-derived neural crest cells may be homologous to Schwann cell precursors, recently shown in mammalian embryos to populate post-embryonic parasympathetic ganglia, including enteric ganglia. Our results suggest that neural-crest-derived Schwann cell precursors made an important contribution to the ancient enteric nervous system of early jawless vertebrates, a role that was largely subsumed by vagal neural crest cells in early gnathostomes.
[Mh] Termos MeSH primário: Evolução Biológica
Sistema Nervoso Entérico/citologia
Sistema Nervoso Entérico/embriologia
Crista Neural/citologia
Neurônios/citologia
Petromyzon/embriologia
Tronco/embriologia
[Mh] Termos MeSH secundário: Animais
Diferenciação Celular
Linhagem da Célula
Movimento Celular
Gânglios/citologia
Gânglios/embriologia
Fibras Nervosas
Crista Neural/embriologia
Tubo Neural/citologia
Tubo Neural/embriologia
Células de Schwann/citologia
Nervo Vago/citologia
Nervo Vago/embriologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1038/nature21679


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[PMID]:28183864
[Au] Autor:Green WW; Boyes K; McFadden C; Daghfous G; Auclair F; Zhang H; Li W; Dubuc R; Zielinski BS
[Ad] Endereço:Department of Biological Sciences, University of Windsor, Windsor, ON, Canada N9B3P4.
[Ti] Título:Odorant organization in the olfactory bulb of the sea lamprey.
[So] Source:J Exp Biol;220(Pt 7):1350-1359, 2017 Apr 01.
[Is] ISSN:1477-9145
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Olfactory sensory neurons innervate the olfactory bulb, where responses to different odorants generate a chemotopic map of increased neural activity within different bulbar regions. In this study, insight into the basal pattern of neural organization of the vertebrate olfactory bulb was gained by investigating the lamprey. Retrograde labelling established that lateral and dorsal bulbar territories receive the axons of sensory neurons broadly distributed in the main olfactory epithelium and that the medial region receives sensory neuron input only from neurons projecting from the accessory olfactory organ. The response duration for local field potential recordings was similar in the lateral and dorsal regions, and both were longer than medial responses. All three regions responded to amino acid odorants. The dorsal and medial regions, but not the lateral region, responded to steroids. These findings show evidence for olfactory streams in the sea lamprey olfactory bulb: the lateral region responds to amino acids from sensory input in the main olfactory epithelium, the dorsal region responds to steroids (taurocholic acid and pheromones) and to amino acids from sensory input in the main olfactory epithelium, and the medial bulbar region responds to amino acids and steroids stimulating the accessory olfactory organ. These findings indicate that olfactory subsystems are present at the base of vertebrate evolution and that regionality in the lamprey olfactory bulb has some aspects previously seen in other vertebrate species.
[Mh] Termos MeSH primário: Petromyzon/anatomia & histologia
Petromyzon/fisiologia
Olfato
[Mh] Termos MeSH secundário: Animais
Odorantes/análise
Bulbo Olfatório/anatomia & histologia
Bulbo Olfatório/fisiologia
Bulbo Olfatório/ultraestrutura
Neurônios Receptores Olfatórios/citologia
Neurônios Receptores Olfatórios/metabolismo
Neurônios Receptores Olfatórios/ultraestrutura
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170211
[St] Status:MEDLINE
[do] DOI:10.1242/jeb.150466


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[PMID]:28012382
[Au] Autor:Bussy U; Chung-Davidson YW; Li K; Fissette SD; Buchinger EG; Li W
[Ad] Endereço:Department of Fisheries and Wildlife, Michigan State University, Room 13 Natural Resources Building, 480 Wilson Road, East Lansing, MI 48824, USA. Electronic address: ugo.bussy@gmail.com.
[Ti] Título:A validated LC-MS/MS method for thyroid hormone determination in sea lamprey (Petromyzon marinus) plasma, gill, kidney and liver.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1041-1042:77-84, 2017 Jan 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A UPLC-MS/MS method was developed to provide a reproducible, sensitive and quantitative assay to determine thyroid hormones in sea lamprey tissues and plasma. l-Thyroxine (T4) and its two triiodo-thyronine isomers have been simultaneously quantified and validated for plasma, gill, liver, and kidney matrices. Multiple sample preparation techniques were investigated to achieve optimal sample matrix digestion and clean-up. Enzymatic digestion followed by protein precipitation was selected to process the samples. The developed method exhibited excellent linearity for all analytes with regression coefficients higher than 0.99 for concentrations ranged from 10 to 50,000pg/mL. The limit of detection (LOD) was under 1pg/mL while the limit of quantification (LOQ) was estimated as 10pg/mL. This method was validated according to the FDA guidance and applied to determine thyroid hormone levels in plasma, gill and kidney of sea lamprey exposed to a sex pheromone. With appropriate implementation and further validation, this method could be applied to tissues in other species including humans.
[Mh] Termos MeSH primário: Cromatografia Líquida/métodos
Petromyzon/metabolismo
Espectrometria de Massas em Tandem/métodos
Hormônios Tireóideos/análise
[Mh] Termos MeSH secundário: Animais
Brânquias/química
Rim/química
Limite de Detecção
Modelos Lineares
Fígado/química
Reprodutibilidade dos Testes
Hormônios Tireóideos/metabolismo
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Thyroid Hormones)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170309
[Lr] Data última revisão:
170309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161225
[St] Status:MEDLINE


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[PMID]:27957739
[Au] Autor:Imre I; Di Rocco RT; McClure H; Johnson NS; Brown GE
[Ad] Endereço:Biology Department, Algoma University, 1520 Queen St East, Sault Ste Marie, ON, P6A 2G4, Canada.
[Ti] Título:Migratory-stage sea lamprey Petromyzon marinus stop responding to conspecific damage-released alarm cues after 4 h of continuous exposure in laboratory conditions.
[So] Source:J Fish Biol;90(4):1297-1304, 2017 Apr.
[Is] ISSN:1095-8649
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study investigated the length of avoidance response of migratory-stage sea lamprey Petromyzon marinus exposed continuously to conspecific damage-released alarm cues for varying lengths of time in laboratory stream channels. Ten replicate groups of P. marinus, separated by sex, were exposed to either deionized water control or to P. marinus extract for 0, 2 or 4 h continuously. Petromyzon marinus maintained their avoidance response to the conspecific damage-released alarm cue after continuous exposure to the alarm cue for 0 and 2 h but not 4 h. Beyond being one of the first studies in regards to sensory-olfactory adaptation-acclimation of fishes to alarm cues of any kind, these results have important implications for use of conspecific alarm cues in P. marinus control. For example, continuous application of conspecific alarm cue during the day, when P. marinus are inactive and hiding, may result in sensory adaptation to the odour by nightfall when they migrate upstream.
[Mh] Termos MeSH primário: Migração Animal/fisiologia
Sinais (Psicologia)
Odorantes
Percepção Olfatória
Petromyzon/fisiologia
[Mh] Termos MeSH secundário: Animais
Reação de Fuga
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161214
[St] Status:MEDLINE
[do] DOI:10.1111/jfb.13231


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[PMID]:27558222
[Au] Autor:Goetz F; Smith SE; Goetz G; Murphy CA
[Ad] Endereço:University of Wisconsin - Milwaukee, School of Freshwater Sciences, 600 East Greenfield Ave., Milwaukee, WI, 53204, USA. rick.goetz@noaa.gov.
[Ti] Título:Sea lampreys elicit strong transcriptomic responses in the lake trout liver during parasitism.
[So] Source:BMC Genomics;17:675, 2016 08 24.
[Is] ISSN:1471-2164
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The sea lamprey (Petromyzon marinus) is a jawless vertebrate that parasitizes fish as an adult and, with overfishing, was responsible for the decline in lake trout (Salvelinus namaycush) populations in the Great Lakes. While laboratory studies have looked at the rates of wounding on various fish hosts, there have been few investigations on the physiological effects of lamprey wounding on the host. In the current study, two morphotypes of lake trout, leans and siscowets, were parasitized in the laboratory by sea lampreys and the liver transcriptomes of parasitized and nonparasitized fish were analyzed by RNA-seq (DESeq2 and edgeR) to determine which genes and gene pathways (Ingenuity Pathway Analysis) were altered by lamprey parasitism. RESULTS: Overall, genes encoding molecules involved in catalytic (e.g., enzymatic) and binding activities (factors and regulators) predominated the regulated gene lists. In siscowets, the top upregulated gene was growth arrest and DNA-damage-inducible protein and for leans it was interleukin-18-binding protein. In leans, the most significantly downregulated gene was UDP-glucuronosyltransferase 2A2 - DESeq2 or phosphotriesterase related - edgeR. For siscowets, the top downregulated gene was C-C motif chemokine 19 - DESeq2 or GTP-binding protein Rhes - edgeR. Gene pathways associated with inflammatory-related responses or factors (cytokines, chemokines, oxidative stress, apoptosis) were regulated following parasitism in both morphotypes. However, pathways related to energy metabolism (glycolysis, gluconeogenesis, lipolysis, lipogenesis) were also regulated. These pathways or the intensity or direction (up/downregulation) of regulation were different between leans and siscowets. Finally, one of the most significantly downregulated pathways in both leans and siscowets was the kynurenine (tryptophan degradation) pathway. CONCLUSIONS: The results indicate a strong transcriptional response in the lake trout to lamprey parasitism that entails genes involved in the regulation of inflammation and cellular damage. Responses to energy utilization as well as hydromineral balance also occurred indicating an adjustment in the host to energy demands and osmotic imbalances during parasitism. Given the role of the kynurenine pathway in promoting immunotolerance in mammals, the downregulation observed in this pathway during parasitism may signify an attempt by the host to inhibit any feedback suppression of the immune response to the lamprey.
[Mh] Termos MeSH primário: Proteínas de Peixes/genética
Perfilação da Expressão Gênica/métodos
Petromyzon/fisiologia
Análise de Sequência de RNA/métodos
Truta/parasitologia
[Mh] Termos MeSH secundário: Animais
Metabolismo Energético
Regulação da Expressão Gênica
Redes Reguladoras de Genes
Cinurenina/metabolismo
Lagos
Truta/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Fish Proteins); 343-65-7 (Kynurenine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171118
[Lr] Data última revisão:
171118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160826
[St] Status:MEDLINE
[do] DOI:10.1186/s12864-016-2959-9


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[PMID]:27508405
[Au] Autor:McConville MB; Hubert TD; Remucal CK
[Ad] Endereço:Environmental Chemistry and Technology Program, University of Wisconsin - Madison , Madison, Wisconsin 53706, United States.
[Ti] Título:Direct Photolysis Rates and Transformation Pathways of the Lampricides TFM and Niclosamide in Simulated Sunlight.
[So] Source:Environ Sci Technol;50(18):9998-10006, 2016 Sep 20.
[Is] ISSN:1520-5851
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The lampricides 3-trifluoromethyl-4-nitrophenol (TFM) and 2',5-dichloro-4'-nitrosalicylanilide (niclosamide) are directly added to many tributaries of the Great Lakes that harbor the invasive parasitic sea lamprey. Despite their long history of use, the fate of lampricides is not well understood. This study evaluates the rate and pathway of direct photodegradation of both lampricides under simulated sunlight. The estimated half-lives of TFM range from 16.6 ± 0.2 h (pH 9) to 32.9 ± 1.0 h (pH 6), while the half-lives of niclosamide range from 8.88 ± 0.52 days (pH 6) to 382 ± 83 days (pH 9) assuming continuous irradiation over a water depth of 55 cm. Both compounds degrade to form a series of aromatic intermediates, simple organic acids, ring cleavage products, and inorganic ions. Experimental data were used to construct a kinetic model which demonstrates that the aromatic products of TFM undergo rapid photolysis and emphasizes that niclosamide degradation is the rate-limiting step to dehalogenation and mineralization of the lampricide. This study demonstrates that TFM photodegradation is likely to occur on the time scale of lampricide applications (2-5 days), while niclosamide, the less selective lampricide, will undergo minimal direct photodegradation during its passage to the Great Lakes.
[Mh] Termos MeSH primário: Niclosamida
Fotólise
[Mh] Termos MeSH secundário: Animais
Cinética
Petromyzon/metabolismo
Luz Solar
Poluentes Químicos da Água/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Water Pollutants, Chemical); 8KK8CQ2K8G (Niclosamide)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170608
[Lr] Data última revisão:
170608
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160811
[St] Status:MEDLINE
[do] DOI:10.1021/acs.est.6b02607



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