Base de dados : MEDLINE
Pesquisa : B01.050.150.900.493.602.200.800 [Categoria DeCS]
Referências encontradas : 1781 [refinar]
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[PMID]:29198705
[Au] Autor:Zeng J; Li Z; Lui EY; Lam SH; Swaminathan K
[Ad] Endereço:Department of Biological Sciences, National University of Singapore 117543, Singapore.
[Ti] Título:Tilapia and human CLIC2 structures are highly conserved.
[So] Source:Biochem Biophys Res Commun;495(2):1752-1757, 2018 01 08.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chloride intracellular channels (CLICs) exist in soluble and membrane bound forms. We have determined the crystal structure of soluble Clic2 from the euryhaline teleost fish Oreochromis mossambicus. Structural comparison of tilapia and human CLIC2 with other CLICs shows that these proteins are highly conserved. We have also compared the expression levels of clic2 in selected osmoregulatory organs of tilapia, acclimated to freshwater, seawater and hypersaline water. Structural conservation of vertebrate CLICs implies that they might play conserved roles. Also, tissue-specific responsiveness of clic2 suggests that it might be involved in iono-osmoregulation under extreme conditions in tilapia.
[Mh] Termos MeSH primário: Canais de Cloreto/química
Canais de Cloreto/genética
Proteínas de Peixes/química
Proteínas de Peixes/genética
Tilápia/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Canais de Cloreto/metabolismo
Sequência Conservada
Proteínas de Peixes/metabolismo
Seres Humanos
Modelos Moleculares
Osmorregulação/genética
Osmorregulação/fisiologia
Filogenia
Conformação Proteica
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Salinidade
Homologia de Sequência de Aminoácidos
Tilápia/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (CLIC2 protein, human); 0 (Chloride Channels); 0 (Fish Proteins); 0 (RNA, Messenger)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE


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[PMID]:29272917
[Au] Autor:Liping S; Qiuming L; Jian F; Xiao L; Yongliang Z
[Ad] Endereço:Yunnan Institute of Food Safety, Kunming University of Science and Technology , 727 South Jingming Road, Kunming, Yunnan 650500, People's Republic of China.
[Ti] Título:Purification and Characterization of Peptides Inhibiting MMP-1 Activity with C Terminate of Gly-Leu from Simulated Gastrointestinal Digestion Hydrolysates of Tilapia (Oreochromis niloticus) Skin Gelatin.
[So] Source:J Agric Food Chem;66(3):593-601, 2018 Jan 24.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Tilapia skin gelatin hydrolysates (TSGHs) were prepared by simulated gastrointestinal digestion and separated by gel filtration and semi-preparative reversed-phase high-performance liquid chromatography. The anti-photoaging effects were evaluated using an ultraviolet radiation B (UVB)-induced mouse embryonic fibroblast (MEF) photoaging model in vitro. Three fractions from TSGHs with high inhibitory intercellular matrix metalloproteinase-1 (MMP-1) activities and reactive oxygen species (ROS) production were obtained. Three key peptides, GYTGL, LGATGL, and VLGL, were identified, and their C terminate was Gly-Leu. Three peptides were synthesized and exhibited a significant inhibition of intercellular MMP-1 activity and ROS production. Furthermore, three peptides inhibiting MMP-1 activities were evaluated through their docking of S ' and S ' active pockets of MMP-1. Hydrogen bonds and C terminate Gly-Leu played important roles. Finally, the protective effects of three peptides on intercellular collagen in UVB-induced MEFs were compared. Our results indicated that tilapia gelatin peptides exhibited potential activities to prevent and regulate photoaging.
[Mh] Termos MeSH primário: Gelatina/química
Inibidores de Metaloproteinases de Matriz/química
Peptídeos/química
Pele/química
[Mh] Termos MeSH secundário: Motivos de Aminoácidos
Animais
Antioxidantes/química
Antioxidantes/isolamento & purificação
Antioxidantes/farmacologia
Colágeno/metabolismo
Digestão
Fibroblastos/efeitos dos fármacos
Fibroblastos/enzimologia
Fibroblastos/metabolismo
Fibroblastos/efeitos da radiação
Proteínas de Peixes/química
Proteínas de Peixes/isolamento & purificação
Proteínas de Peixes/farmacologia
Trato Gastrointestinal/metabolismo
Gelatina/isolamento & purificação
Gelatina/farmacologia
Metaloproteinase 1 da Matriz/química
Metaloproteinase 1 da Matriz/metabolismo
Inibidores de Metaloproteinases de Matriz/isolamento & purificação
Camundongos
Modelos Biológicos
Simulação de Acoplamento Molecular
Peptídeos/isolamento & purificação
Peptídeos/farmacologia
Espécies Reativas de Oxigênio/metabolismo
Pele/metabolismo
Tilápia
Raios Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Fish Proteins); 0 (Matrix Metalloproteinase Inhibitors); 0 (Peptides); 0 (Reactive Oxygen Species); 9000-70-8 (Gelatin); 9007-34-5 (Collagen); EC 3.4.24.7 (Matrix Metalloproteinase 1)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171224
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04196


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[PMID]:28986317
[Au] Autor:Xia JH; Li HL; Li BJ; Gu XH; Lin HR
[Ad] Endereço:State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, College of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, PR China. Electronic address: xiajunh3@mail.sysu.edu.cn.
[Ti] Título:Acute hypoxia stress induced abundant differential expression genes and alternative splicing events in heart of tilapia.
[So] Source:Gene;639:52-61, 2018 Jan 10.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Hypoxia is one of the critical environmental stressors for fish in aquatic environments. Although accumulating evidences indicate that gene expression is regulated by hypoxia stress in fish, how genes undergoing differential gene expression and/or alternative splicing (AS) in response to hypoxia stress in heart are not well understood. Using RNA-seq, we surveyed and detected 289 differential expressed genes (DEG) and 103 genes that undergo differential usage of exons and splice junctions events (DUES) in heart of a hypoxia tolerant fish, Nile tilapia, Oreochromis niloticus following 12h hypoxic treatment. The spatio-temporal expression analysis validated the significant association of differential exon usages in two randomly selected DUES genes (fam162a and ndrg2) in 5 tissues (heart, liver, brain, gill and spleen) sampled at three time points (6h, 12h, and 24h) under acute hypoxia treatment. Functional analysis significantly associated the differential expressed genes with the categories related to energy conservation, protein synthesis and immune response. Different enrichment categories were found between the DEG and DUES dataset. The Isomerase activity, Oxidoreductase activity, Glycolysis and Oxidative stress process were significantly enriched for the DEG gene dataset, but the Structural constituent of ribosome and Structural molecule activity, Ribosomal protein and RNA binding protein were significantly enriched only for the DUES genes. Our comparative transcriptomic analysis reveals abundant stress responsive genes and their differential regulation function in the heart tissues of Nile tilapia under acute hypoxia stress. Our findings will facilitate future investigation on transcriptome complexity and AS regulation during hypoxia stress in fish.
[Mh] Termos MeSH primário: Processamento Alternativo
Expressão Gênica
Hipóxia/genética
Estresse Fisiológico/genética
Tilápia/genética
[Mh] Termos MeSH secundário: Animais
Éxons
Sequenciamento de Nucleotídeos em Larga Escala
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171227
[Lr] Data última revisão:
171227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171008
[St] Status:MEDLINE


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[PMID]:29191316
[Au] Autor:Bangma JT; Reiner JL; Botha H; Cantu TM; Gouws MA; Guillette MP; Koelmel JP; Luus-Powell WJ; Myburgh J; Rynders O; Sara JR; Smit WJ; Bowden JA
[Ad] Endereço:Medical University of South Carolina, Department of Obstetrics and Gynecology, Charleston, SC 29412, United States.
[Ti] Título:Tissue distribution of perfluoroalkyl acids and health status in wild Mozambique tilapia (Oreochromis mossambicus) from Loskop Dam, Mpumalanga, South Africa.
[So] Source:J Environ Sci (China);61:59-67, 2017 Nov.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:This study examined concentrations of 15 perfluoroalkyl acids (PFAAs) in tissues from male Mozambique tilapia (Oreochromis mossambicus) collected at Loskop Dam, Mpumalanga, South Africa in 2014 and 2016. Nine of the 15 PFAAs were detected frequently and were included in statistical analysis and included two of the most commonly known PFAAs, perfluorooctanesulfonic acid (PFOS) (median, 41.6ng/g) and perfluorooctanoic acid (PFOA) (median, 0.0825ng/g). Of the tissues measured, plasma (2016 and 2014 median, 22.2ng/g) contained the highest PFAA burden followed by (in descending order): liver (median, 11.6ng/g), kidney (median, 9.04ng/g), spleen (median, 5.92ng/g), adipose (median, 2.54ng/g), and muscle (median, 1.11ng/g). Loskop Dam tilapia have been affected by an inflammatory disease of the adipose tissue known as pansteatitis, so this study also aimed to investigate relationships between PFAA tissue concentrations and incidence of pansteatitis or fish health status. Results revealed that healthy tilapia exhibited an overall higher (p-value<0.05) PFAA burden than pansteatitis-affected tilapia across all tissues. Further analysis showed that organs previously noted in the literature to contain the highest PFAA concentrations, such as kidney, liver, and plasma, were the organs driving the difference in PFAA burden between the two tilapia groups. Care must be taken in the interpretations we draw from not only the results of our study, but also other PFAA measurements made on populations (human and wildlife alike) under differing health status.
[Mh] Termos MeSH primário: Monitoramento Ambiental
Fluorcarbonetos/metabolismo
Tilápia/fisiologia
Poluentes Químicos da Água/metabolismo
[Mh] Termos MeSH secundário: Ácidos Alcanossulfônicos/análise
Ácidos Alcanossulfônicos/metabolismo
Animais
Caprilatos/análise
Caprilatos/metabolismo
Fluorcarbonetos/análise
África do Sul
Distribuição Tecidual
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkanesulfonic Acids); 0 (Caprylates); 0 (Fluorocarbons); 0 (Water Pollutants, Chemical); 947VD76D3L (perfluorooctanoic acid); 9H2MAI21CL (perfluorooctane sulfonic acid)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171207
[Lr] Data última revisão:
171207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE


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[PMID]:28737156
[Au] Autor:Dabrowski J; Oberholster P; Steyl J; Osthoff G; Hugo A; Power DM; van Wyk JH
[Ad] Endereço:Sustainability Research Unit, Nelson Mandela Metropolitan University, Private Bag x6531, George 6530, South Africa.
[Ti] Título:Thyroid function of steatitis-affected Mozambique tilapia Oreochromis mossambicus from a sub-tropical African reservoir.
[So] Source:Dis Aquat Organ;125(2):101-113, 2017 07 24.
[Is] ISSN:0177-5103
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Thyroid function and nutritional indicators were measured in obese, steatitis-affected Mozambique tilapia Oreochromis mossambicus from Loskop Reservoir (LR), South Africa. Plasma thyroid hormones (especially T3) and thyroid follicle histomorphology revealed high levels of activity in every aspect of the thyroid cascade measured in fish from LR compared to a reference population of steatitis-free fish. Concurrent measurements of nutritional state including plasma lipids, liver lipid content and hepatocyte size showed that fish from LR had significant energy stores indicative of abundant nutritional intake. There were distinct sex and seasonal differences, with the highest plasma lipids and T3 levels observed in steatitis-affected females during spring and summer. Positive correlations were observed between plasma lipids (especially cholesterol) and T3 concentrations in fish from both populations, indicating a link between lipid metabolism and thyroid function. There was no direct evidence of thyroid disruption, but this cannot be ruled out until further research determines the factors that underlie the homeostatic shift leading to elevated plasma and liver lipids and T3 levels in steatitis-affected tilapia.
[Mh] Termos MeSH primário: Doenças dos Peixes/etiologia
Obesidade/veterinária
Esteatite/metabolismo
Glândula Tireoide/fisiologia
Tilápia
[Mh] Termos MeSH secundário: Animais
Colesterol/sangue
Fígado/química
Fígado/metabolismo
Triglicerídeos/sangue
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Triglycerides); 059QF0KO0R (Water); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170725
[St] Status:MEDLINE
[do] DOI:10.3354/dao03138


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[PMID]:28645657
[Au] Autor:Ibor OR; Adeogun AO; Chukwuka AV; Arukwe A
[Ad] Endereço:Department of Zoology, University of Ibadan, Ibadan, Nigeria; Department of Zoology and Environmental Biology, University of Calabar, Calabar, Nigeria.
[Ti] Título:Gross pathology, physiological and toxicological responses in relation to metals and persistent organic pollutants (POPs) burden in tilapia species from Ogun River, Nigeria.
[So] Source:Mar Environ Res;129:245-257, 2017 Aug.
[Is] ISSN:1879-0291
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We have investigated gross pathology, physiological (steroid precursors) and toxicological responses (oxidative stress and phase II biotransformation) in relation to tissue contaminant burden in Tilapia species along the entire length (320 km) of Ogun River, Nigeria. The Ogun River is the longest and largest river in Southwestern Nigeria located along heavily industrialized cities and receives complex mixtures of effluents. A total of 1074 tilapias were collected from three sampling points (Abeokuta, Isheri and Ikorodu) and from an upstream control point (Igboho) and evaluated for gross pathological changes, hepatic transcript levels for oxidative stress and phase II biotransformation responses. Trace metal concentrations and POPs in muscle samples were analyzed using ICP-MS and GC-MS respectively. Evaluation of gross pathological changes showed a 50-, 33-, 17 and 0% prevalence of hepatic tumors at the Ikorodu, Abeokuta, Isheri and Igboho sites, respectively. Plasma concentrations of cholesterol and pregnenolone showed apparent significant decreases at downstream sites of the control point in both male and female fish (except for pregnenolone levels of male fish at Ikorodu). Inversely, gst, ugt-1, ZuCu-sod and sod significantly increased in fish collected from downstream sites, compared with the control site and these increases paralleled the significant increase in trace metal and POPs concentrations at these sites. PCA revealed a site related association between measured toxicological responses and contaminant burden, indicating a potential cause-and-effect relationship. Thus, the possible adaptation of Ogun River Tilapia species to contaminants may have significant consequences on cellular, physiological and biochemical processes regulating metabolism, growth, development and reproduction, and also have serious human health consequences, since the Ogun River is used for fisheries and domestic water supply for surrounding neighborhoods.
[Mh] Termos MeSH primário: Monitoramento Ambiental
Metais/toxicidade
Tilápia/fisiologia
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Misturas Complexas/análise
Misturas Complexas/toxicidade
Feminino
Fígado/metabolismo
Masculino
Metais/análise
Nigéria
Estresse Oxidativo
Rios
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Complex Mixtures); 0 (Metals); 0 (Water Pollutants, Chemical)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170625
[St] Status:MEDLINE


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[PMID]:28604263
[Au] Autor:de Núñez MO
[Ad] Endereço:Departamento de Biodiversidad y Biología Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón II, 1428 Buenos Aires, Argentina.
[Ti] Título:Redescription of Austrodiplostomum compactum (Trematoda: Diplostomidae) from its Type Host and Locality in Venezuela, and of Austrodiplostomum mordax from Argentina.
[So] Source:J Parasitol;103(5):497-505, 2017 Oct.
[Is] ISSN:1937-2345
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Austrodiplostomum compactum from Nannopterum brasilianus, and its metacercaria from Geophagus sp. and Oreochromis mossambicus captured (1979) at its type locality, Valencia Lake, Venezuela, by the author, are redescribed. The adult is characterized by its large body size, and an oral sucker smaller than the pharynx. The metacercaria has a similar body size as the adult, and the small genital primordia occupy 4.1-7.3% of body length. Experimental infections in chickens with metacercariae of Diplostomulum mordax from brains of Odonthestes bonariensis, captured (2015) at Dique Paso de las Piedras, near Bahia Blanca City, Buenos Aires Province, Argentina, resulted in 10 adults 5 days postexposure. These adults correspond to Austrodiplostomum mordax as described from N. brasilianus at Lacombe Lagoon, Buenos Aires Province, and differ from A. compactum in their smaller body size, and an oral sucker larger than the pharynx. The metacercaria has a similar body size as the adult and differs mainly in that the larger genital primordia occupy 11.6-13.8% of body length. The status of earlier published Austrodiplostomum species in the American continent is discussed in view of available morphological and molecular data. A lectotype of A. mordax is here designated, and Austrodiplostomum ostrowskiae is considered as a new synonym of A. compactum.
[Mh] Termos MeSH primário: Ciclídeos/parasitologia
Doenças dos Peixes/parasitologia
Tilápia/parasitologia
Trematódeos/classificação
Infecções por Trematódeos/veterinária
[Mh] Termos MeSH secundário: Animais
Argentina
Biomphalaria/parasitologia
Doenças das Aves/parasitologia
Aves
Encéfalo/parasitologia
Galinhas/parasitologia
Olho/parasitologia
Intestinos/parasitologia
Lagos
Trematódeos/anatomia & histologia
Trematódeos/isolamento & purificação
Infecções por Trematódeos/parasitologia
Venezuela
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE
[do] DOI:10.1645/16-128


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[PMID]:28602910
[Au] Autor:Pinto PIS; Estêvão MD; Santos S; Andrade A; Power DM
[Ad] Endereço:Centre of Marine Sciences (CCMAR), Universidade do Algarve, Campus de Gambelas, 8005-139 Faro, Portugal. Electronic address: ppinto@ualg.pt.
[Ti] Título:In vitro screening for estrogenic endocrine disrupting compounds using Mozambique tilapia and sea bass scales.
[So] Source:Comp Biochem Physiol C Toxicol Pharmacol;199:106-113, 2017 Sep.
[Is] ISSN:1532-0456
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A wide range of estrogenic endocrine disruptors (EDCs) are accumulating in the environment and may disrupt the physiology of aquatic organisms. The effects of EDCs on fish have mainly been assessed using reproductive endpoints and in vivo animal experiments. We used a simple non-invasive assay to evaluate the impact of estrogens and EDCs on sea bass (Dicentrarchus labrax) and tilapia (Oreochromis mossambicus) scales. These were exposed to estradiol (E2), two phytoestrogens and six anthropogenic estrogenic/anti-estrogenic EDCs and activities of enzymes related to mineralized tissue turnover (TRAP, tartrate-resistant acid phosphatase and ALP, alkaline phosphatase) were measured. Semi-quantitative RT-PCR detected the expression of both membrane and nuclear estrogen receptors in the scales of both species, confirming scales as a target for E2 and EDCs through different mechanisms. Changes in TRAP or ALP activities after 30minute and 24h exposure were detected in sea bass and tilapia scales treated with E2 and three EDCs, although compound-, time- and dose-specific responses were observed for the two species. These results support again that the mineralized tissue turnover of fish is regulated by estrogens and reveals that the scales are a mineralized estrogen-responsive tissue that may be affected by some EDCs. The significance of these effects for whole animal physiology needs to be further explored. The in vitro fish scale bioassay is a promising non-invasive screening tool for E2 and EDCs effects, although the low sensitivity of TRAP/ALP quantification limits their utility and indicates that alternative endpoints are required.
[Mh] Termos MeSH primário: Bass/fisiologia
Disruptores Endócrinos/toxicidade
Estrogênios/toxicidade
Receptores Estrogênicos/metabolismo
Pele/efeitos dos fármacos
Tilápia/fisiologia
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Fosfatase Alcalina/metabolismo
Animais
Aquicultura
Bass/crescimento & desenvolvimento
Membrana Celular/efeitos dos fármacos
Membrana Celular/metabolismo
Núcleo Celular/efeitos dos fármacos
Núcleo Celular/metabolismo
Estradiol/toxicidade
Moduladores de Receptor Estrogênico/toxicidade
Proteínas de Peixes/genética
Proteínas de Peixes/metabolismo
Masculino
Fitoestrógenos/toxicidade
Portugal
Isoformas de Proteínas/genética
Isoformas de Proteínas/metabolismo
Receptores Estrogênicos/genética
Pele/química
Pele/crescimento & desenvolvimento
Pele/metabolismo
Especificidade da Espécie
Fosfatase Ácida Resistente a Tartarato/metabolismo
Tilápia/crescimento & desenvolvimento
Distribuição Tecidual
Testes de Toxicidade
Toxicocinética
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Endocrine Disruptors); 0 (Estrogen Receptor Modulators); 0 (Estrogens); 0 (Fish Proteins); 0 (Phytoestrogens); 0 (Protein Isoforms); 0 (Receptors, Estrogen); 0 (Water Pollutants, Chemical); 4TI98Z838E (Estradiol); EC 3.1.3.1 (Alkaline Phosphatase); EC 3.1.3.2 (Tartrate-Resistant Acid Phosphatase)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE


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[PMID]:28570951
[Au] Autor:Yu L; Zhai Q; Zhu J; Zhang C; Li T; Liu X; Zhao J; Zhang H; Tian F; Chen W
[Ad] Endereço:State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, PR China; UK-China Joint Centre on Probiotic Bacteria, United Kingdom.
[Ti] Título:Dietary Lactobacillus plantarum supplementation enhances growth performance and alleviates aluminum toxicity in tilapia.
[So] Source:Ecotoxicol Environ Saf;143:307-314, 2017 Sep.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:We investigated the protection offered by the probiotic Lactobacillus plantarum CCFM639 against waterborne Al exposure in tilapia. Fish were allocated to control, CCFM639-only, Al-only or Al plus CCFM639 groups. The fish were exposed to 2.73mg/L Al ions for 4 weeks. The probiotic was incorporated into the fish diet at 10 CFU/g and provided twice daily. Our results showed that L. plantarum CCFM639 significantly enhanced feed utilization, growth performance and antioxidant ability in the absence of waterborne Al exposure. When fish were exposed to Al, dietary supplementation with the strain effectively decreased the death rate and accumulation of Al in tissues, and enhanced growth performance. Moreover, Al-induced changes in hematobiochemical parameters and hepatic oxidative stress and histopathology were also alleviated. Therefore, L. plantarum CCFM639 may be a novel dietary supplement for fish to enhance growth performance and prevent aquaculture and food safety problems induced by Al pollution.
[Mh] Termos MeSH primário: Alumínio/toxicidade
Lactobacillus plantarum
Estresse Oxidativo/efeitos dos fármacos
Tilápia/crescimento & desenvolvimento
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Alumínio/metabolismo
Ração Animal
Animais
Suplementos Nutricionais
Pesqueiros
Fígado/efeitos dos fármacos
Fígado/metabolismo
Fígado/patologia
Probióticos
Tilápia/metabolismo
Poluentes Químicos da Água/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Water Pollutants, Chemical); CPD4NFA903 (Aluminum)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE


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[PMID]:28496325
[Au] Autor:Zhou T; Sui B; Mo X; Sun J
[Ad] Endereço:Shanghai Biomaterials Research and Testing Center, Shanghai Key Laboratory of Stomatology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine.
[Ti] Título:Multifunctional and biomimetic fish collagen/bioactive glass nanofibers: fabrication, antibacterial activity and inducing skin regeneration in vitro and in vivo.
[So] Source:Int J Nanomedicine;12:3495-3507, 2017.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:The development of skin wound dressings with excellent properties has always been an important challenge in the field of biomedicine. In this study, biomimetic electrospun fish collagen/bioactive glass (Col/BG) nanofibers were prepared. Their structure, tensile strength, antibacterial activity and biological effects on human keratinocytes, human dermal fibroblasts and human vascular endothelial cells were investigated. Furthermore, the Sprague Dawley rat skin defect model was used to validate their effect on wound healing. The results showed that compared with pure fish collagen nanofibers, the tensile strength of the Col/BG nanofibers increased to 21.87±0.21 Mpa, with a certain degree of antibacterial activity against . It was also found that the Col/BG nanofibers promoted the adhesion, proliferation and migration of human keratinocytes. Col/BG nanofibers induced the secretion of type one collagen and vascular endothelial growth factor by human dermal fibroblasts, which further stimulated the proliferation of human vascular endothelial cells. Animal experimentation indicated that the Col/BG nanofibers could accelerate rat skin wound healing. This study developed a type of multifunctional and biomimetic fish Col/BG nanofibers, which had the ability to induce skin regeneration with adequate tensile strength and antibacterial activity. The Col/BG nanofibers are also easily available and inexpensive, providing the possibility for using as a functional skin wound dressing.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Colágeno/química
Nanofibras/química
Pele/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Antibacterianos/química
Biomimética/métodos
Fibroblastos/efeitos dos fármacos
Fibroblastos/metabolismo
Proteínas de Peixes/química
Vidro
Seres Humanos
Queratinócitos/efeitos dos fármacos
Masculino
Nanofibras/administração & dosagem
Ratos Sprague-Dawley
Regeneração/efeitos dos fármacos
Dermatopatias Infecciosas/tratamento farmacológico
Staphylococcus aureus/efeitos dos fármacos
Resistência à Tração
Tilápia
Fator A de Crescimento do Endotélio Vascular/metabolismo
Cicatrização/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Fish Proteins); 0 (Vascular Endothelial Growth Factor A); 9007-34-5 (Collagen)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170513
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S132459



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