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  1 / 1854 MEDLINE  
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[PMID]:29282542
[Au] Autor:Bode NWF; Seitz MJ
[Ad] Endereço:Department of Engineering Mathematics, University of Bristol, Bristol, BS8 1UB, UK. nikolai.bode@bristol.ac.uk.
[Ti] Título:Using Hidden Markov Models to characterise intermittent social behaviour in fish shoals.
[So] Source:Naturwissenschaften;105(1-2):7, 2017 Dec 27.
[Is] ISSN:1432-1904
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The movement of animals in groups is widespread in nature. Understanding this phenomenon presents an important problem in ecology with many applications that range from conservation to robotics. Underlying all group movements are interactions between individual animals and it is therefore crucial to understand the mechanisms of this social behaviour. To date, despite promising methodological developments, there are few applications to data of practical statistical techniques that inferentially investigate the extent and nature of social interactions in group movement. We address this gap by demonstrating the usefulness of a Hidden Markov Model approach to characterise individual-level social movement in published trajectory data on three-spined stickleback shoals (Gasterosteus aculeatus) and novel data on guppy shoals (Poecilia reticulata). With these models, we formally test for speed-mediated social interactions and verify that they are present. We further characterise this inferred social behaviour and find that despite the substantial shoal-level differences in movement dynamics between species, it is qualitatively similar in guppies and sticklebacks. It is intermittent, occurring in varying numbers of individuals at different time points. The speeds of interacting fish follow a bimodal distribution, indicating that they are either stationary or move at a preferred mean speed, and social fish with more social neighbours move at higher speeds, on average. Our findings and methodology present steps towards characterising social behaviour in animal groups.
[Mh] Termos MeSH primário: Modelos Biológicos
Poecilia/fisiologia
Smegmamorpha/fisiologia
Comportamento Social
[Mh] Termos MeSH secundário: Animais
Cadeias de Markov
Atividade Motora
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE
[do] DOI:10.1007/s00114-017-1534-9


  2 / 1854 MEDLINE  
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[PMID]:29051075
[Au] Autor:Zhang H; Qin G; Sun J; Zhang B; Lin Q
[Ad] Endereço:CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, Guangdong 510301, PR China.
[Ti] Título:The evolution and functional characterization of lined seahorse (Hippocampus erectus) CCKs involved in fasting and thermal stress response.
[So] Source:Gen Comp Endocrinol;255:56-63, 2018 Jan 01.
[Is] ISSN:1095-6840
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The peptide cholecystokinin (CCK) plays an important role in the regulation of vertebrate appetite and feeding behaviour. In the present study, the full-length cDNA and genomic DNA sequences of two CCK precursors were cloned and analysed in the Syngnathidae fish, the lined seahorse (Hippocampus erectus). Both CCK1 and CCK2 in the seahorse consist of four exons. The sequence of the octapeptide of seahorse CCK1 (DYMGWMDF) was the same as that of the chicken and human, while the octapeptide of seahorse CCK2 (DYEGWMDF) was unique among vertebrates. According to the phylogenetic analysis, two types of CCKs were produced by teleost-specific genome duplication (TGD). Both CCK1 and CCK2 were highly expressed in the brain, while detectable amounts of CCK1 mRNA in the brood pouch and CCK2 mRNA in the intestine were also found. Both CCK1 and CCK2 mRNA levels significantly increased during the transition from endogenous to exogenous nutrition. Additionally, fasting induced a significant increase in the CCK1 mRNA expression in the brain of juvenile seahorses but had no effect on CCK2 transcript levels. In addition, the CCK1 and CCK2 mRNA levels in the seahorse brain significantly increased after a high-temperature treatment. Thus, the mRNA expression of CCK had obvious tissue specificities and this preliminary study opens new avenues for further functional studies on the endocrine regulations of CCK in the transition from endogenous to exogenous nutrition, food intake regulation and metabolism in the seahorse.
[Mh] Termos MeSH primário: Colecistocinina/genética
Evolução Molecular
Jejum/fisiologia
Smegmamorpha/metabolismo
Estresse Fisiológico
Temperatura Ambiente
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Fenômenos Fisiológicos da Nutrição Animal
Animais
Sequência de Bases
Colecistocinina/química
Colecistocinina/metabolismo
Clonagem Molecular
DNA Complementar/genética
Seres Humanos
Larva/metabolismo
Especificidade de Órgãos
Filogenia
Precursores de Proteínas/metabolismo
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Complementary); 0 (Protein Precursors); 0 (RNA, Messenger); 78206-77-6 (procholecystokinin); 9011-97-6 (Cholecystokinin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171021
[St] Status:MEDLINE


  3 / 1854 MEDLINE  
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[PMID]:28746754
[Au] Autor:Siren J; Ovaskainen O; Merilä J
[Ad] Endereço:Metapopulation Research Centre, Department of Biosciences, University of Helsinki, Helsinki, Finland.
[Ti] Título:Structure and stability of genetic variance-covariance matrices: A Bayesian sparse factor analysis of transcriptional variation in the three-spined stickleback.
[So] Source:Mol Ecol;26(19):5099-5113, 2017 Oct.
[Is] ISSN:1365-294X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The genetic variance-covariance matrix (G) is a quantity of central importance in evolutionary biology due to its influence on the rate and direction of multivariate evolution. However, the predictive power of empirically estimated G-matrices is limited for two reasons. First, phenotypes are high-dimensional, whereas traditional statistical methods are tuned to estimate and analyse low-dimensional matrices. Second, the stability of G to environmental effects and over time remains poorly understood. Using Bayesian sparse factor analysis (BSFG) designed to estimate high-dimensional G-matrices, we analysed levels variation and covariation in 10,527 expressed genes in a large (n = 563) half-sib breeding design of three-spined sticklebacks subject to two temperature treatments. We found significant differences in the structure of G between the treatments: heritabilities and evolvabilities were higher in the warm than in the low-temperature treatment, suggesting more and faster opportunity to evolve in warm (stressful) conditions. Furthermore, comparison of G and its phenotypic equivalent P revealed the latter is a poor substitute of the former. Most strikingly, the results suggest that the expected impact of G on evolvability-as well as the similarity among G-matrices-may depend strongly on the number of traits included into analyses. In our results, the inclusion of only few traits in the analyses leads to underestimation in the differences between the G-matrices and their predicted impacts on evolution. While the results highlight the challenges involved in estimating G, they also illustrate that by enabling the estimation of large G-matrices, the BSFG method can improve predicted evolutionary responses to selection.
[Mh] Termos MeSH primário: Evolução Biológica
Variação Genética
Smegmamorpha/genética
Temperatura Ambiente
[Mh] Termos MeSH secundário: Animais
Teorema de Bayes
Feminino
Masculino
Modelos Genéticos
Fenótipo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1111/mec.14265


  4 / 1854 MEDLINE  
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[PMID]:29059215
[Au] Autor:Jakubaviciute E; Bergström U; Eklöf JS; Haenel Q; Bourlat SJ
[Ad] Endereço:Nature Research Centre, Vilnius, Lithuania.
[Ti] Título:DNA metabarcoding reveals diverse diet of the three-spined stickleback in a coastal ecosystem.
[So] Source:PLoS One;12(10):e0186929, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The three-spined stickleback (Gasterosteus aculeatus L., hereafter 'stickleback') is a common mesopredatory fish in marine, coastal and freshwater areas. In large parts of the Baltic Sea, stickleback densities have increased >10-fold during the last decades, and it is now one of the dominating fish species both in terms of biomass and effects on lower trophic levels. Still, relatively little is known about its diet-knowledge which is essential to understand the increasing role sticklebacks play in the ecosystem. Fish diet analyses typically rely on visual identification of stomach contents, a labour-intensive method that is made difficult by prey digestion and requires expert taxonomic knowledge. However, advances in DNA-based metabarcoding methods promise a simultaneous identification of most prey items, even from semi-digested tissue. Here, we studied the diet of stickleback from the western Baltic Sea coast using both DNA metabarcoding and visual analysis of stomach contents. Using the cytochrome oxidase (CO1) marker we identified 120 prey taxa in the diet, belonging to 15 phyla, 83 genera and 84 species. Compared to previous studies, this is an unusually high prey diversity. Chironomids, cladocerans and harpacticoids were dominating prey items. Large sticklebacks were found to feed more on benthic prey, such as amphipods, gastropods and isopods. DNA metabarcoding gave much higher taxonomic resolution (median rank genus) than visual analysis (median rank order), and many taxa identified using barcoding could not have been identified visually. However, a few taxa identified by visual inspection were not revealed by barcoding. In summary, our results suggest that the three-spined stickleback feeds on a wide variety of both pelagic and benthic organisms, indicating that the strong increase in stickleback populations may affect many parts of the Baltic Sea coastal ecosystem.
[Mh] Termos MeSH primário: Código de Barras de DNA Taxonômico
Ecossistema
Smegmamorpha/fisiologia
[Mh] Termos MeSH secundário: Animais
Smegmamorpha/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171024
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186929


  5 / 1854 MEDLINE  
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[PMID]:28882453
[Au] Autor:Tharuka MDN; Bathige SDNK; Lee J
[Ad] Endereço:Department of Marine Life Sciences & Fish Vaccine Research Center, Jeju National University, Jeju Self-Governing Province 63243, Republic of Korea.
[Ti] Título:Molecular cloning, biochemical characterization, and expression analysis of two glutathione S-transferase paralogs from the big-belly seahorse (Hippocampus abdominalis).
[So] Source:Comp Biochem Physiol B Biochem Mol Biol;214:1-11, 2017 Dec.
[Is] ISSN:1879-1107
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Glutathione S-transferases (GSTs, EC 2.5.1.18) are important Phase II detoxifying enzymes that catalyze hydrophobic, electrophilic xenobiotic substance with the conjugation of reduced glutathione (GSH). In this study, GSTµ and GSTρ paralogs of GST in the big belly seahorse (Hippocampus abdominalis; HaGSTρ, HaGSTµ) were biochemically, molecularly, functionally characterized to determine their detoxification range and protective capacities upon different pathogenic stresses. HaGSTρ and HaGSTµ are composed of coding sequences of 681bp and 654bp, which encode proteins 225 and 217 amino acids, with predicted molecular masses of 26.06kDa and 25.74kDa respectively. Sequence analysis revealed that both HaGSTs comprise the characteristic GSH-binding site in the thioredoxin-like N-terminal domain and substrate binding site in the C-terminal domain. The recombinant HaGSTρ and HaGSTµ proteins catalyzed the model GST substrate 1-chloro-2, 4-dinitrobenzene (CDNB). Enzyme kinetic analysis revealed different K and V values for each rHaGST, suggesting that they have different conjugation rates. The optimum conditions (pH, temperature) and inhibitory assays of each protein demonstrated different optimal ranges. However, HaGSTµ was highly expressed in the ovary and gill, whereas HaGSTρ was highly expressed in the gill and pouch. mRNA expression of HaGSTρ and HaGSTµ was significantly elevated upon lipopolysaccharide, Poly (I:C), and Edwardsiella tarda challenges in liver and in blood cells as well as with Streptococcus iniae challenge in blood cells. From these collective experimental results, we propose that HaGSTρ and HaGSTµ are effective in detoxifying xenobiotic toxic agents, and importantly, their mRNA expression could be stimulated by immunological stress signals in the aquatic environment.
[Mh] Termos MeSH primário: Proteínas de Peixes/química
Glutationa Transferase/química
Smegmamorpha/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Sítios de Ligação
Clonagem Molecular
Dinitroclorobenzeno/imunologia
Dinitroclorobenzeno/metabolismo
Escherichia coli/genética
Escherichia coli/metabolismo
Proteínas de Peixes/agonistas
Proteínas de Peixes/genética
Proteínas de Peixes/imunologia
Expressão Gênica
Glutationa Transferase/genética
Glutationa Transferase/imunologia
Isoenzimas/química
Isoenzimas/genética
Isoenzimas/imunologia
Cinética
Lipopolissacarídeos/farmacologia
Modelos Moleculares
Especificidade de Órgãos
Filogenia
Poli I-C/farmacologia
Ligação Proteica
Domínios e Motivos de Interação entre Proteínas
Estrutura Secundária de Proteína
Estrutura Terciária de Proteína
Proteínas Recombinantes/química
Proteínas Recombinantes/genética
Proteínas Recombinantes/imunologia
Alinhamento de Sequência
Homologia de Sequência de Aminoácidos
Smegmamorpha/classificação
Smegmamorpha/imunologia
Smegmamorpha/microbiologia
Especificidade por Substrato
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fish Proteins); 0 (Isoenzymes); 0 (Lipopolysaccharides); 0 (Recombinant Proteins); EC 2.5.1.18 (Glutathione Transferase); GE3IBT7BMN (Dinitrochlorobenzene); O84C90HH2L (Poly I-C)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE


  6 / 1854 MEDLINE  
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[PMID]:28850571
[Au] Autor:Lickwar CR; Camp JG; Weiser M; Cocchiaro JL; Kingsley DM; Furey TS; Sheikh SZ; Rawls JF
[Ad] Endereço:Department of Molecular Genetics and Microbiology, Center for the Genomics of Microbial Systems, Duke University, Durham, North Carolina, United States of America.
[Ti] Título:Genomic dissection of conserved transcriptional regulation in intestinal epithelial cells.
[So] Source:PLoS Biol;15(8):e2002054, 2017 Aug.
[Is] ISSN:1545-7885
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The intestinal epithelium serves critical physiologic functions that are shared among all vertebrates. However, it is unknown how the transcriptional regulatory mechanisms underlying these functions have changed over the course of vertebrate evolution. We generated genome-wide mRNA and accessible chromatin data from adult intestinal epithelial cells (IECs) in zebrafish, stickleback, mouse, and human species to determine if conserved IEC functions are achieved through common transcriptional regulation. We found evidence for substantial common regulation and conservation of gene expression regionally along the length of the intestine from fish to mammals and identified a core set of genes comprising a vertebrate IEC signature. We also identified transcriptional start sites and other putative regulatory regions that are differentially accessible in IECs in all 4 species. Although these sites rarely showed sequence conservation from fish to mammals, surprisingly, they drove highly conserved IEC expression in a zebrafish reporter assay. Common putative transcription factor binding sites (TFBS) found at these sites in multiple species indicate that sequence conservation alone is insufficient to identify much of the functionally conserved IEC regulatory information. Among the rare, highly sequence-conserved, IEC-specific regulatory regions, we discovered an ancient enhancer upstream from her6/HES1 that is active in a distinct population of Notch-positive cells in the intestinal epithelium. Together, these results show how combining accessible chromatin and mRNA datasets with TFBS prediction and in vivo reporter assays can reveal tissue-specific regulatory information conserved across 420 million years of vertebrate evolution. We define an IEC transcriptional regulatory network that is shared between fish and mammals and establish an experimental platform for studying how evolutionarily distilled regulatory information commonly controls IEC development and physiology.
[Mh] Termos MeSH primário: Proteínas de Peixes/metabolismo
Regulação da Expressão Gênica
Mucosa Intestinal/metabolismo
RNA Mensageiro/metabolismo
Smegmamorpha/metabolismo
Peixe-Zebra/metabolismo
[Mh] Termos MeSH secundário: Animais
California
Colo/citologia
Colo/crescimento & desenvolvimento
Colo/metabolismo
Duodeno/citologia
Duodeno/crescimento & desenvolvimento
Duodeno/metabolismo
Feminino
Proteínas de Peixes/genética
Perfilação da Expressão Gênica/veterinária
Genômica/métodos
Seres Humanos
Íleo/citologia
Íleo/crescimento & desenvolvimento
Íleo/metabolismo
Mucosa Intestinal/citologia
Mucosa Intestinal/crescimento & desenvolvimento
Jejuno/citologia
Jejuno/crescimento & desenvolvimento
Jejuno/metabolismo
Larva/crescimento & desenvolvimento
Larva/metabolismo
Masculino
Camundongos
Especificidade de Órgãos
Rios
Smegmamorpha/crescimento & desenvolvimento
Especificidade da Espécie
Peixe-Zebra/crescimento & desenvolvimento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fish Proteins); 0 (RNA, Messenger)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170830
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pbio.2002054


  7 / 1854 MEDLINE  
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[PMID]:28821183
[Au] Autor:Peichel CL; Sullivan ST; Liachko I; White MA
[Ad] Endereço:Divisons of Basic Sciences and Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA
[Ti] Título:Improvement of the Threespine Stickleback Genome Using a Hi-C-Based Proximity-Guided Assembly.
[So] Source:J Hered;108(6):693-700, 2017 09 01.
[Is] ISSN:1465-7333
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Scaffolding genomes into complete chromosome assemblies remains challenging even with the rapidly increasing sequence coverage generated by current next-generation sequence technologies. Even with scaffolding information, many genome assemblies remain incomplete. The genome of the threespine stickleback (Gasterosteus aculeatus), a fish model system in evolutionary genetics and genomics, is not completely assembled despite scaffolding with high-density linkage maps. Here, we first test the ability of a Hi-C based proximity-guided assembly (PGA) to perform a de novo genome assembly from relatively short contigs. Using Hi-C based PGA, we generated complete chromosome assemblies from a distribution of short contigs (20-100 kb). We found that 96.40% of contigs were correctly assigned to linkage groups (LGs), with ordering nearly identical to the previous genome assembly. Using available bacterial artificial chromosome (BAC) end sequences, we provide evidence that some of the few discrepancies between the Hi-C assembly and the existing assembly are due to structural variation between the populations used for the 2 assemblies or errors in the existing assembly. This Hi-C assembly also allowed us to improve the existing assembly, assigning over 60% (13.35 Mb) of the previously unassigned (~21.7 Mb) contigs to LGs. Together, our results highlight the potential of the Hi-C based PGA method to be used in combination with short read data to perform relatively inexpensive de novo genome assemblies. This approach will be particularly useful in organisms in which it is difficult to perform linkage mapping or to obtain high molecular weight DNA required for other scaffolding methods.
[Mh] Termos MeSH primário: Mapeamento Cromossômico/métodos
Smegmamorpha/genética
[Mh] Termos MeSH secundário: Alaska
Animais
Cromossomos Artificiais Bacterianos
Mapeamento de Sequências Contíguas
Genômica
Masculino
Análise de Sequência de DNA/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170820
[St] Status:MEDLINE
[do] DOI:10.1093/jhered/esx058


  8 / 1854 MEDLINE  
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Robaldo, Ricardo Berteaux
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[PMID]:28735239
[Au] Autor:Zebral YD; Costa PG; de Castro Knopp B; Lansini LR; Zafalon-Silva B; Bianchini A; Robaldo RB
[Ad] Endereço:Programa de Pós-Graduação em Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade Federal do Rio Grande, 96203-900, Rio Grande, RS, Brazil. Electronic address: yurizebral@hotmail.com.
[Ti] Título:Effects of a glyphosate-based herbicide in pejerrey Odontesthes humensis embryonic development.
[So] Source:Chemosphere;185:860-867, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Glyphosate-based herbicides (GBH) are the major pesticides used worldwide. Among them, the Roundup formulations are the most popular. Some aspects of GBH toxicity are well known, such as induction of oxidative stress. However, embryotoxicity is scarcely known. Therefore, the aim of the present study was to evaluate the effect of exposure to different Roundup Transorb R concentrations (0.36, 1.80, 3.62 and 5.43 mg glyphosate a.e./L) on Odontesthes humensis embryonic development. Embryos were sampled at three exposure times (48, 72 and 96 h). After 48 h, the stage of embryonic development and the number of somite pairs were analyzed; after 72 h, the percentage of pigmented embryos were evaluated and after 96 h, the eye diameter (ED) and the distance between eyes (DE) were measured. Mortality rates were daily calculated. Results show that Roundup exposure to all concentrations did not alter the endpoints evaluated at 48 and 72 h. On the other hand, exposure for 96 h to all concentrations induced a concentration-dependent reduction in ED and DE. Additionally, exposure to 5.43 mg a.e./L increased mortality. These findings indicate that Roundup has the potential to produce morphological alterations in fish embryos even at the lower and ecologically relevant concentration tested (0.36 mg a.e./L). This result corroborates the hypothesis that glyphosate alters the retinoic acid signaling pathway. Additionally, our findings indicate that exposure to high concentrations of Roundup (5.43 mg a.e./L) for 96 h causes high mortality rates of fish embryos. This is the first report of GBH embryotoxicity in an endemic fish of southern areas in South America.
[Mh] Termos MeSH primário: Embrião não Mamífero/efeitos dos fármacos
Desenvolvimento Embrionário/efeitos dos fármacos
Glicina/análogos & derivados
Herbicidas/toxicidade
[Mh] Termos MeSH secundário: Animais
Glicina/toxicidade
Estresse Oxidativo/efeitos dos fármacos
Smegmamorpha/embriologia
América do Sul
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Herbicides); 4632WW1X5A (glyphosate); TE7660XO1C (Glycine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170724
[St] Status:MEDLINE


  9 / 1854 MEDLINE  
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[PMID]:28704398
[Au] Autor:Bukhari SA; Saul MC; Seward CH; Zhang H; Bensky M; James N; Zhao SD; Chandrasekaran S; Stubbs L; Bell AM
[Ad] Endereço:Carl R. Woese Institute for Genomic Biology, University of Illinois, Urbana Champaign, Urbana, IL, United States of America.
[Ti] Título:Temporal dynamics of neurogenomic plasticity in response to social interactions in male threespined sticklebacks.
[So] Source:PLoS Genet;13(7):e1006840, 2017 Jul.
[Is] ISSN:1553-7404
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Animals exhibit dramatic immediate behavioral plasticity in response to social interactions, and brief social interactions can shape the future social landscape. However, the molecular mechanisms contributing to behavioral plasticity are unclear. Here, we show that the genome dynamically responds to social interactions with multiple waves of transcription associated with distinct molecular functions in the brain of male threespined sticklebacks, a species famous for its behavioral repertoire and evolution. Some biological functions (e.g., hormone activity) peaked soon after a brief territorial challenge and then declined, while others (e.g., immune response) peaked hours afterwards. We identify transcription factors that are predicted to coordinate waves of transcription associated with different components of behavioral plasticity. Next, using H3K27Ac as a marker of chromatin accessibility, we show that a brief territorial intrusion was sufficient to cause rapid and dramatic changes in the epigenome. Finally, we integrate the time course brain gene expression data with a transcriptional regulatory network, and link gene expression to changes in chromatin accessibility. This study reveals rapid and dramatic epigenomic plasticity in response to a brief, highly consequential social interaction.
[Mh] Termos MeSH primário: Comportamento Animal/fisiologia
Plasticidade Neuronal/genética
Smegmamorpha/genética
Comportamento Social
Transcrição Genética
[Mh] Termos MeSH secundário: Animais
Evolução Biológica
Cérebro/fisiologia
Cromatina/genética
Diencéfalo/fisiologia
Epigenômica
Genoma
Análise de Sequência de RNA
Smegmamorpha/fisiologia
Fatores de Transcrição/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chromatin); 0 (Transcription Factors)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pgen.1006840


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[PMID]:28612229
[Au] Autor:Genç TO; Yilmaz F
[Ad] Endereço:Biology Department, Science Faculty, Mugla Sitki Koçman University, 48000, Kötekli Mugla, Turkey. tuncerokangenc@gmail.com.
[Ti] Título:Metal Accumulations in Water, Sediment, Crab (Callinectes sapidus) and Two Fish Species (Mugil cephalus and Anguilla anguilla) from the Köycegiz Lagoon System-Turkey: An Index Analysis Approach.
[So] Source:Bull Environ Contam Toxicol;99(2):173-181, 2017 Aug.
[Is] ISSN:1432-0800
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The concentrations of six metals (Hg, Cd, Cu, Pb, Cr and Zn) individual total metal load (IMBI) values and its relation to condition index were determined in water, sediment and tissues of crab (Callinectes sapidus) and two fish species (Mugil cephalus and Anguilla anguilla) inhabiting Köycegiz Lagoon System. The average distribution of the IMBI values ranged from 0.033 to 0.265. Distribution patterns of IMBI in species follow the sequence: A. anguilla > M. cephalus > C. sapidus. Results showed that there are positive relationships between species sizes and metal levels in most cases. The concentrations of Pb in muscle in the three studied species were in all cases considerably higher than the maximum levels set by law. Average Cd, Cu and Zn values in M. cephalus were also higher than the limits proposed for fish by FAO/WHO, EC and TFC. Therefore, the human consumption of all analysed species is not recommended.
[Mh] Termos MeSH primário: Anguilla/metabolismo
Braquiúros/metabolismo
Monitoramento Ambiental/métodos
Metais Pesados/análise
Smegmamorpha/metabolismo
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Animais
Sedimentos Geológicos/química
Seres Humanos
Metais Pesados/metabolismo
Músculos/química
Água do Mar/química
Frutos do Mar/análise
Turquia
Poluentes Químicos da Água/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Metals, Heavy); 0 (Water Pollutants, Chemical)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.1007/s00128-017-2121-7



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