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Pesquisa : B01.050.150.900.493.850.280 [Categoria DeCS]
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[PMID]:28683335
[Au] Autor:Brodeur JC; Sanchez M; Castro L; Rojas DE; Cristos D; Damonte MJ; Poliserpi MB; D'Andrea MF; Andriulo AE
[Ad] Endereço:Instituto de Recursos Biológicos, Centro de Investigaciones de Recursos Naturales (CIRN), Instituto Nacional de Tecnología Agropecuaria (INTA), Hurlingham, Buenos Aires, Argentina. Electronic address: brodeur.celine@inta.gob.ar.
[Ti] Título:Accumulation of current-use pesticides, cholinesterase inhibition and reduced body condition in juvenile one-sided livebearer fish (Jenynsia multidentata) from the agricultural Pampa region of Argentina.
[So] Source:Chemosphere;185:36-46, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to characterize the level and nature of the pesticide contamination received by one-sided livebearer fish (Jenynsia multidentata) from a watercourse situated within the main agricultural region of Argentina, and to assess the effects of this contamination on fish health. Juvenile one-sided livebearer fish (Jenynsia multidentata) were collected in December 2011 and March 2012 from three sites along the Pergamino River. Pesticide contamination was characterized by extracting whole fish and analytically determining thirty different pesticide molecules. The biomarkers catalase, glutathione-S-transferase, and cholinesterases were assessed. Body condition was calculated as an estimate of the amount of energy reserves possessed by the fish. Seventeen different pesticides were detected in fish tissues with 81% of captured animals containing at least one pesticide molecule. The pyrethroid insecticides fenvalerate and bifenthrin were most frequently detected, being respectively found in 41.8 and 36.4% of samples tested. Highly toxic dichlorvos and pirimiphos-methyl were detected. Differential levels of contamination could not be established amongst sites but were observed within sites amongst the two sampling dates. The months when pesticide residues were most abundant from in Site A and B corresponded to the months when body condition was at its lowest in the two sites. The inhibition of Che activity in March when body condition was reduced also points to a role of insecticide contamination in the reduction of body condition. These findings provide strong new evidence that current-used agricultural pesticides can accumulate in wild fish and impact their health and energetics.
[Mh] Termos MeSH primário: Inibidores da Colinesterase/metabolismo
Colinesterases/metabolismo
Ciprinodontiformes/metabolismo
Praguicidas/metabolismo
[Mh] Termos MeSH secundário: Agricultura
Animais
Argentina
Biomarcadores
Inibidores da Colinesterase/toxicidade
Ciprinodontiformes/fisiologia
Monitoramento Ambiental
Inseticidas/toxicidade
Nitrilos
Resíduos de Praguicidas
Praguicidas/análise
Praguicidas/toxicidade
Piretrinas/metabolismo
Piretrinas/toxicidade
Rios
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Cholinesterase Inhibitors); 0 (Insecticides); 0 (Nitriles); 0 (Pesticide Residues); 0 (Pesticides); 0 (Pyrethrins); 0 (Water Pollutants, Chemical); 6B66JED0KN (bifenthrin); EC 3.1.1.8 (Cholinesterases); Z6MXZ39302 (fenvalerate)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE


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[PMID]:28609966
[Au] Autor:Volcan MV; Gonçalves ÂC; Lanés LEK
[Ad] Endereço:Instituto Pró-Pampa (IPPampa), Laboratório de Ictiologia. Rua Uruguai, 1242, Centro. CEP 96010-630. Pelotas, Brasil.. matheusvolcan@hotmail.com.
[Ti] Título:First record of blackfin pearlfish Austrolebias nigripinnis (Regan, 1912 (Cyprinodontiformes, Cynolebiidae) from Brazil.
[So] Source:Zootaxa;4254(3):387-390, 2017 Apr 18.
[Is] ISSN:1175-5334
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Austrolebias Costa is a genus of annual fish inhabiting temporary wetlands in the Chaco-Pampasic region of southern Brazil, Uruguay, Paraguay, Bolivia and Argentina (Costa, 2006, Nielsen & Pillet, 2015, Alonso et al., 2016). Currently, about 45 species of Austrolebias are known (Costa, 2006, Volcan et al., 2014, Nielsen & Pillet, 2015), and of these, 24 occur in Rio Grande do Sul, the southernmost state of Brazil, distributed across the Rio Uruguay basin and the Patos-Mirim lagoon system and adjacent coastal areas (Volcan et al., 2015).
[Mh] Termos MeSH primário: Ciprinodontiformes
[Mh] Termos MeSH secundário: Distribuição Animal
Animais
Argentina
Bolívia
Brasil
Paraguai
Uruguai
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.11646/zootaxa.4254.3.9


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[PMID]:28609886
[Au] Autor:Nielsen DTB; Pessali TC; Dutra GM
[Ad] Endereço:Laboratório de Zoologia, Departamento de Biologia, Universidade de Taubaté, Praça Marcelino Monteiro 63, 12030-010, Taubaté, SP, Brazil.. dnielsen@uol.com.br.
[Ti] Título:A new annual fish of the genus Simpsonichthys (Cyprinodontiformes: Cynolebiidae) from the upper Rio Jequitinhonha basin, Brazil.
[So] Source:Zootaxa;4263(1):165-172, 2017 05 08.
[Is] ISSN:1175-5334
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:A new species of Simpsonichthys is described from the upper rio Jequitinhonha basin, Minas Gerais, eastern Brazil. It is diagnosed from all congeners by presenting an A-patterned frontal squamation. Additionally, males of the new species differs from all congeners by the color pattern of body, the color of iris, the absence of contact organs in the pectoral fin, presence of scales on anal-fin base, pectoral-fin length, caudal fin length, and eye diameter. Females of the new species can be diagnosed from remaining congeners by the pectoral-fin length. The conservation status of the new species is evaluated. Comments on the relationships of the new species within the genus Simpsonichthys are presented.
[Mh] Termos MeSH primário: Ciprinodontiformes
[Mh] Termos MeSH secundário: Animais
Brasil
Feminino
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170810
[Lr] Data última revisão:
170810
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.11646/zootaxa.4263.1.8


  4 / 1370 MEDLINE  
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[PMID]:28599128
[Au] Autor:Philippe C; Grégoir AF; Janssens L; Pinceel T; De Boeck G; Brendonck L
[Ad] Endereço:Laboratory of Aquatic Ecology, Evolution and Conservation, University of Leuven, Ch. Deberiotstraat 32, B-3000 Leuven, Belgium; Systemic Physiological and Ecotoxicological Research, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerp, Belgium. Electronic address: charlotte.philippe@kuleuven
[Ti] Título:Acute and chronic sensitivity to copper of a promising ecotoxicological model species, the annual killifish Nothobranchius furzeri.
[So] Source:Ecotoxicol Environ Saf;144:26-35, 2017 Oct.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Nothobranchius furzeri is a promising model for ecotoxicological research due to the species' short life cycle and the production of drought-resistant eggs. Although the species is an emerging vertebrate fish model for several fundamental as well as applied research domains, its potential for ecotoxicological research has not yet been tested. The aim of this study was to characterise the acute and chronic sensitivity of this species to copper as compared to other model organisms. Effects of both acute and chronic copper exposure were tested on survival, life history and physiological traits. We report a 24h-LC of 53.93µg Cu/L, which is situated within the sensitivity range of other model species such as Brook Trout, Fathead Minnow and Rainbow Trout. Moreover, in the full life cycle exposure, we show that an exposure concentration of 10.27µg/L did not cause acute adverse effects (96h), but did cause mortality after prolonged exposure (3-4 weeks). Also chronic, sublethal effects were observed, such as a reduction in growth rate, delayed maturation and postponed reproduction. Based on our results, we define the NOEC at 6.68µg Cu/L, making N. furzeri more sensitive to copper as compared to Brook Trout and Fathead Minnow. We found stimulatory effects on peak fecundity at subinhibitory levels of copper concentrations (hormesis). Finally, we found indications for detoxifying and copper-excreting mechanisms, demonstrating the ability of the fish to cope with this essential metal, even when exposed to stressful amounts. The successful application of current ecotoxicological protocols on N. furzeri and its sensitivity range comparable to that of other model organisms forms the basis to exploit this species in further ecotoxicological practices.
[Mh] Termos MeSH primário: Cobre/toxicidade
Ciprinodontiformes/fisiologia
Ecotoxicologia/métodos
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Relação Dose-Resposta a Droga
Dose Letal Mediana
Reprodução/efeitos dos fármacos
Testes de Toxicidade Aguda
Testes de Toxicidade Crônica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Water Pollutants, Chemical); 789U1901C5 (Copper)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170610
[St] Status:MEDLINE


  5 / 1370 MEDLINE  
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[PMID]:28575749
[Au] Autor:Blewett TA; Simon RA; Turko AJ; Wright PA
[Ad] Endereço:Department of Chemistry and Biochemistry, Wilfrid Laurier University, Waterloo, Ontario, N2L 3C5, Canada. Electronic address: tamzin@ualberta.ca.
[Ti] Título:Copper alters hypoxia sensitivity and the behavioural emersion response in the amphibious fish Kryptolebias marmoratus.
[So] Source:Aquat Toxicol;189:25-30, 2017 Aug.
[Is] ISSN:1879-1514
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Elevated levels of metals have been reported in mangrove ecosystems worldwide. Mangrove fishes also routinely experience severe environmental stressors, such as hypoxia. In the amphibious fish Kryptolebias marmoratus (mangrove rivulus), a key behavioural response to avoid aquatic stress is to leave water (emersion). We hypothesized that copper (Cu) exposure would increase the sensitivity of this behavioural hypoxia avoidance response due to histopathological effects of Cu on gill structure and function. K. marmoratus were exposed to either control (no added Cu) or Cu (300µg/L) for 96h. Following this period, fish were exposed to an acute hypoxic challenge (decline in dissolved oxygen to ∼0% over 15min), and the emersion response was recorded. Gills were examined for histological changes. Fish exposed to Cu emersed at a higher dissolved oxygen level (7.5±0.6%), relative to the control treatment group (5.8±0.4%). Histological analysis showed that the gill surface area increased and the interlamellar cell mass (ILCM) was reduced following Cu exposure, contrary to our prediction. Overall, these data indicate that Cu induces hypoxia-like changes to gill morphology and increases the sensitivity of the hypoxia emersion response.
[Mh] Termos MeSH primário: Comportamento Animal/efeitos dos fármacos
Cobre/toxicidade
Ciprinodontiformes/fisiologia
Brânquias/efeitos dos fármacos
Hipóxia/induzido quimicamente
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Cobre/análise
Ciprinodontiformes/metabolismo
Ecossistema
Brânquias/patologia
Hipóxia/patologia
Hipóxia/psicologia
Oxigênio/análise
Salinidade
Água/química
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Water Pollutants, Chemical); 059QF0KO0R (Water); 789U1901C5 (Copper); S88TT14065 (Oxygen)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE


  6 / 1370 MEDLINE  
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[PMID]:28512060
[Au] Autor:Jimenez M; Goodchild SC; Stockwell CA; Lema SC
[Ad] Endereço:Alan Hancock College, Santa Maria, CA, USA; Biological Sciences Department, Center for Coastal Marine Sciences, California Polytechnic State University, San Luis Obispo, CA, USA.
[Ti] Título:Characterization and phylogenetic analysis of complete mitochondrial genomes for two desert cyprinodontoid fishes, Empetrichthys latos and Crenichthys baileyi.
[So] Source:Gene;626:163-172, 2017 Aug 30.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The Pahrump poolfish (Empetrichthys latos) and White River springfish (Crenichthys baileyi) are small-bodied teleost fishes (order Cyprinodontiformes) endemic to the arid Great Basin and Mojave Desert regions of western North America. These taxa survive as small, isolated populations in remote streams and springs and evolved to tolerate extreme conditions of high temperature and low dissolved oxygen. Both species have experienced severe population declines over the last 50-60years that led to some subspecies being categorized with protected status under the U.S. Endangered Species Act. Here we report the first sequencing of the complete mitochondrial DNA genomes for both E. l. latos and the moapae subspecies of C. baileyi. Complete mitogenomes of 16,546bp nucleotides were obtained from two E. l. latos individuals collected from introduced populations at Spring Mountain Ranch State Park and Shoshone Ponds Natural Area, Nevada, USA, while a single mitogenome of 16,537bp was sequenced for C. b. moapae. The mitogenomes of both species contain 13 protein-encoding genes, twenty-two tRNAs, and two rRNAs (12S and 18S) following the syntenic arrangement typical of Actinopterygiian fish mitogenomes, as well as D-loop control regions of 858bp for E. latos and 842bp for C. baileyi moapae. The two E. latos individuals exhibited only 0.0181% nucleotide sequence divergence across the entire mitogenome, implying little intraspecific mtDNA genetic variation. Comparative phylogenetic analysis of the poolfish and springfish mitochondrial genomes to available mitogenomes of other Cyprinodontoid fishes confirmed the close relationship of these oviparous Empetrichthys and Crenichthys genera to the viviparous goodeid fishes of central Mexico, and showed the combined clade of these fishes to be a sister group to the Profundulidae killifishes. Despite several significant life history and morphological differences between the Empetrichthyinae and Goodienae, estimates of evolutionary genetic distances using two partial regions of mtDNA point to inclusion of the Empetrichthys and Crenichthys genera within the family Goodeidae along with the goodeid fishes of central Mexico.
[Mh] Termos MeSH primário: Ciprinodontiformes/genética
Genoma Mitocondrial
Filogenia
[Mh] Termos MeSH secundário: Animais
Ciprinodontiformes/classificação
Proteínas de Peixes/genética
Especiação Genética
Anotação de Sequência Molecular
Polimorfismo Genético
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fish Proteins)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170727
[Lr] Data última revisão:
170727
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170518
[St] Status:MEDLINE


  7 / 1370 MEDLINE  
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[PMID]:28400296
[Au] Autor:Castro JM; Horn DA; Pu X; Lewis KA
[Ad] Endereço:Department of Chemistry and Biochemistry, Texas State University, 601 University Dr., San Marcos, TX, 78666, United States.
[Ti] Título:Recombinant expression and purification of the RNA-binding LARP6 proteins from fish genetic model organisms.
[So] Source:Protein Expr Purif;134:147-153, 2017 Jun.
[Is] ISSN:1096-0279
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The RNA-binding proteins that comprise the La-related protein (LARP) superfamily have been implicated in a wide range of cellular functions, from tRNA maturation to regulation of protein synthesis. To more expansively characterize the biological function of the LARP6 subfamily, we have recombinantly expressed the full-length LARP6 proteins from two teleost fish, platyfish (Xiphophorus maculatus) and zebrafish (Danio rerio). The yields of the recombinant proteins were enhanced to >2 mg/L using a tandem approach of an N-terminal His -SUMO tag and an iterative solubility screening assay to identify structurally stabilizing buffer components. The domain topologies of the purified fish proteins were probed with limited proteolysis. The fish proteins contain an internal, protease-resistant 40 kDa domain, which is considerably more stable than the comparable domain from the human LARP6 protein. The fish proteins are therefore a lucrative model system in which to study both the evolutionary divergence of this family of La-related proteins and the structure and conformational dynamics of the domains that comprise the LARP6 protein.
[Mh] Termos MeSH primário: Ciprinodontiformes/genética
Expressão Gênica
Proteínas de Ligação a RNA
Proteínas de Peixe-Zebra
Peixe-Zebra/genética
[Mh] Termos MeSH secundário: Animais
Ciprinodontiformes/metabolismo
Seres Humanos
Domínios Proteicos
Proteínas de Ligação a RNA/biossíntese
Proteínas de Ligação a RNA/química
Proteínas de Ligação a RNA/genética
Proteínas de Ligação a RNA/isolamento & purificação
Proteínas Recombinantes/biossíntese
Proteínas Recombinantes/química
Proteínas Recombinantes/genética
Proteínas Recombinantes/isolamento & purificação
Peixe-Zebra/metabolismo
Proteínas de Peixe-Zebra/biossíntese
Proteínas de Peixe-Zebra/química
Proteínas de Peixe-Zebra/genética
Proteínas de Peixe-Zebra/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA-Binding Proteins); 0 (Recombinant Proteins); 0 (Zebrafish Proteins)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170413
[St] Status:MEDLINE


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[PMID]:28377124
[Au] Autor:Pitts PM; Volkoff H
[Ad] Endereço:Department of Biology, Memorial University of Newfoundland, St. John's, NL A1B 3X9, Canada.
[Ti] Título:Characterization of appetite-regulating factors in platyfish, Xiphophorus maculatus (Cyprinodontiformes Poeciliidae).
[So] Source:Comp Biochem Physiol A Mol Integr Physiol;208:80-88, 2017 Jun.
[Is] ISSN:1531-4332
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The regulation of energy in fish, like most vertebrates, is a complex process that involves a number of brain and peripheral hormones. These signals include anorexigenic (e.g. cholecystokinin (CCK) and cocaine- and amphetamine-regulated transcript (CART)) as well as orexigenic (e.g. orexin and neuropeptide Y (NPY)) peptides. Platyfish, Xiphophorus maculatus, are freshwater viviparous fish for which little is known about the endocrine mechanisms regulating feeding. In order to elucidate the role of these peptides in the regulation of feeding of platyfish, we examined the effects of peripheral injections of CCK and orexin on feeding behavior and food intake. Injections of CCK decreased both food intake and searching behavior, while injections of orexin increased searching behavior but did not affect food consumption. In order to better characterize these peptides, we examined their mRNA tissue distribution and assessed the effects of a 10-day fast on their brain and intestine expressions in both males and females. CCK, CART, NPY and orexin all show widespread distributions in brain and several peripheral tissues, including intestine and gonads. Fasting induced decreases in both CCK and CART and an increase in orexin mRNA expressions in the brain and a decrease in CCK expression in the intestine, but did not affect either expressions of NPY. There were no significant sex-specific differences in either the behavioral responses to injections or the expression responses to fasting. The widespread distribution and the fasting-induced changes in expression of these peptides suggest that they might have several physiological roles in platyfish, including the regulation of feeding.
[Mh] Termos MeSH primário: Apetite/genética
Metabolismo Energético/genética
Comportamento Alimentar/fisiologia
Neuropeptídeo Y/genética
[Mh] Termos MeSH secundário: Animais
Apetite/efeitos dos fármacos
Colecistocinina/administração & dosagem
Colecistocinina/metabolismo
Ciprinodontiformes/fisiologia
Ingestão de Alimentos/efeitos dos fármacos
Ingestão de Alimentos/genética
Metabolismo Energético/efeitos dos fármacos
Jejum
Comportamento Alimentar/efeitos dos fármacos
Feminino
Regulação da Expressão Gênica/efeitos dos fármacos
Masculino
Proteínas do Tecido Nervoso/genética
Proteínas do Tecido Nervoso/metabolismo
Neuropeptídeo Y/metabolismo
Orexinas/administração & dosagem
Orexinas/metabolismo
RNA Mensageiro
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nerve Tissue Proteins); 0 (Neuropeptide Y); 0 (Orexins); 0 (RNA, Messenger); 0 (cocaine- and amphetamine-regulated transcript protein); 9011-97-6 (Cholecystokinin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE


  9 / 1370 MEDLINE  
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[PMID]:28345808
[Au] Autor:Lu Y; Boswell M; Boswell W; Kneitz S; Hausmann M; Klotz B; Regneri J; Savage M; Amores A; Postlethwait J; Warren W; Schartl M; Walter R
[Ad] Endereço:The Xiphophorus Genetic Stock Center, Department of Chemistry and Biochemistry, Texas State University, San Marcos, Texas.
[Ti] Título:Molecular genetic analysis of the melanoma regulatory locus in Xiphophorus interspecies hybrids.
[So] Source:Mol Carcinog;56(8):1935-1944, 2017 Aug.
[Is] ISSN:1098-2744
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Development of spontaneous melanoma in Xiphophorus interspecies backcross hybrid progeny, (X. hellerii × [X. maculatus Jp 163 A × X. hellerii]) is due to Mendelian segregation of a oncogene (xmrk) and a molecularly uncharacterized locus, called R(Diff), on LG5. R(Diff) is thought to suppresses the activity of xmrk in healthy X. maculatus Jp 163 A parental species that rarely develop melanoma. To better understand the molecular genetics of R(Diff), we utilized RNA-Seq to study allele-specific gene expression of spontaneous melanoma tumors and corresponding normal skin samples derived from 15 first generation backcross (BC ) hybrids and 13 fifth generation (BC ) hybrids. Allele-specific expression was determined for all genes and assigned to parental allele inheritance for each backcross hybrid individual. Results showed that genes residing in a 5.81 Mbp region on LG5 were exclusively expressed from the X. hellerii alleles in tumor-bearing BC hybrids. This observation indicates this region is consistently homozygous for X. hellerii alleles in tumor bearing animals, and therefore defines this region to be the R(Diff) locus. The R(Diff) locus harbors 164 gene models and includes the previously characterized R(Diff) candidate, cdkn2x. Twenty-one genes in the R(Diff) region show differential expression in the tumor samples compared to normal skin tissue. These results further characterize the R(Diff) locus and suggest tumor suppression may require a multigenic region rather than a single gene variant. Differences in gene expression between tumor and normal skin tissue in this region may indicate interactions among several genes are required for backcross hybrid melanoma development.
[Mh] Termos MeSH primário: Ciprinodontiformes/genética
Regulação Neoplásica da Expressão Gênica
Melanoma Experimental/genética
Neoplasias Cutâneas/genética
[Mh] Termos MeSH secundário: Alelos
Animais
Cruzamentos Genéticos
Feminino
Proteínas de Peixes/genética
Loci Gênicos
Hibridização Genética
Masculino
Melanoma Experimental/patologia
Receptores Proteína Tirosina Quinases/genética
Pele/metabolismo
Pele/patologia
Neoplasias Cutâneas/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fish Proteins); EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases); EC 2.7.10.1 (Xmrk protein, Xiphophorus)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170328
[St] Status:MEDLINE
[do] DOI:10.1002/mc.22651


  10 / 1370 MEDLINE  
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[PMID]:28288428
[Au] Autor:Sánchez JA; Varela AS; Corcini CD; da Silva JC; Primel EG; Caldas S; Klein RD; Martins CM
[Ad] Endereço:Programa de Pós-Graduação em Biologia de Ambientes Aquáticos Continentais, Instituto de Ciências Biológicas, Universidade Federal do Rio Grande, Av. Itália km 8, 96203-900, Rio Grande, RS, Brazil.
[Ti] Título:Effects of Roundup formulations on biochemical biomarkers and male sperm quality of the livebearing Jenynsia multidentata.
[So] Source:Chemosphere;177:200-210, 2017 Jun.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Roundup formulations are the most consumed glyphosate-based herbicides in the world. When applied, they may reach water bodies and exert toxicity toward non-target species. This study evaluated and compared the effects of different variations of Roundup on biochemical biomarkers as oxidative parameters and Acethylchorinesterase (AChE) activity, and sperm quality of the livebearing Jenynsia multidentata. Fish were acutely (96 h) exposed to Roundup Original (RO), Roundup Transorb (RT) and Roundup WG (RWG) at 0.0, 0.5, 1 and 5 mg L of nominal glyphosate. The highest mortality (60%) was observed for fish exposed to RT at the highest concentration tested and at 0.5 mg L non-mortality was observed, so this concentration was chosen for the experiments. Fish exposed to RO and RT (24 and 96 h) presented a state of oxidative imbalance, which caused lipid peroxidation (LPO) in their livers. Oxidative stress was more severe in RO treatment, which may be resulted in the highest hepathosomatic index at 96 h. However, fish exposed to RT presented a marked inhibition of AChE activity from membrane cells of muscle and brain tissues. Sperm quality was investigated in livebearing exposed (24 and 96 h) to the three formulations. Spermatozoa motility and concentration were affected by all formulations. Overall, Roundup formulations are harmful to the fish J. multidentata at 0.5 mg L of glyphosate; however, mechanisms and potential of toxicity are different between formulations. The J. multidentata also represents a sensitive species and a good regional bio-monitor.
[Mh] Termos MeSH primário: Biomarcadores/química
Ciprinodontiformes
Herbicidas/toxicidade
Espermatozoides/efeitos dos fármacos
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Glicina/análogos & derivados
Glicina/toxicidade
Peroxidação de Lipídeos/efeitos dos fármacos
Fígado/efeitos dos fármacos
Masculino
Estresse Oxidativo/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Herbicides); 0 (Water Pollutants, Chemical); 4632WW1X5A (glyphosate); TE7660XO1C (Glycine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170314
[St] Status:MEDLINE



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