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[PMID]:29381759
[Au] Autor:Narayan E; Sawyer G; Parisella S
[Ad] Endereço:School of Science and Health, Western Sydney University, Locked Bag 1797, Penrith, New South Wales, Australia.
[Ti] Título:Faecal glucocorticoid metabolites and body temperature in Australian merino ewes (Ovis aries) during summer artificial insemination (AI) program.
[So] Source:PLoS One;13(1):e0191961, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Reproductive wastage is a key issue for sheep producers, both regionally and globally. The reproductive output of farm animals can be influenced by physiological and environmental factors. Rapid and reliable quantification of physiological stress can provide a useful tool for designing and testing on-farm management interventions to improve farm animal welfare and productivity. In this study, we quantified physiological stress non-invasively using faecal glucocorticoid metabolites-FGMs analysis and body temperature measurements of 15 superovulated donor merino ewes (Ovis aries) during participation in artificial insemination (AI) program conducted during 2015/2016 Australian summer. We hypothesized that low percentage transferable embryos in donor merino ewes will be associated positively with higher body temperature and/or higher FGMs in these ewes. Temperature humidity index (THI) was calculated and found within high thermal stress range during the two AI trials. Overall, results showed none of the factors (ewe ID, AI trial no., THI or FGMs) were significant for reduced percentage transferrable embryos, except ewe body temperature was highly significant (p = 0.014). Within AI trial comparisons showed significant positive associations between higher FGMs and body temperature with reduced transferrable embryos. These results suggest that Australian merino ewes participating in summer AI trials can experience physiological stress. Prolonged activation of the stress endocrine response and high body temperature (e.g. ensued from heat stress) could impact on ewe reproductive output. Therefore, future research should apply minimally invasive physiological tools to gather baseline information on physiological stress in merino sheep to enable the development of new farm-friendly methods of managing stress.
[Mh] Termos MeSH primário: Fezes
Glucocorticoides/metabolismo
Inseminação Artificial
[Mh] Termos MeSH secundário: Animais
Austrália
Clima
Feminino
Técnicas Imunoenzimáticas
Estações do Ano
Ovinos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Glucocorticoids)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180131
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191961


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[PMID]:29377922
[Au] Autor:Sage M; Nadeau M; Forand-Choinière C; Mousseau J; Vandamme J; Berger C; Tremblay-Roy JS; Tissier R; Micheau P; Fortin-Pellerin É
[Ad] Endereço:Department of Pediatrics and Department of Pharmacology and Physiology, Université de Sherbrooke, Sherbrooke, Québec, Canada.
[Ti] Título:Assessing the impacts of total liquid ventilation on left ventricular diastolic function in a model of neonatal respiratory distress syndrome.
[So] Source:PLoS One;13(1):e0191885, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Filling the lung with dense liquid perfluorocarbons during total liquid ventilation (TLV) might compress the myocardium, a plausible explanation for the instability occasionally reported with this technique. Our objective is to assess the impacts of TLV on the cardiovascular system, particularly left ventricular diastolic function, in an ovine model of neonatal respiratory distress syndrome. METHOD: Eight newborns lambs, 3.0 ± 0.4 days (3.2 ± 0.3kg) were used in this crossover experimental study. Animals were intubated, anesthetized and paralyzed. Catheters were inserted in the femoral and pulmonary arteries. A high-fidelity pressure catheter was inserted into the left ventricle. Surfactant deficiency was induced by repeated lung lavages with normal saline. TLV was then conducted for 2 hours using a liquid ventilator prototype. Thoracic echocardiography and cardiac output assessment by thermodilution were performed before and during TLV. RESULTS: Left ventricular end diastolic pressure (LVEDP) (9.3 ± 2.1 vs. 9.2 ± 2.4mmHg, p = 0.89) and dimension (1.90 ± 0.09 vs. 1.86 ± 0.12cm, p = 0.72), negative dP/dt (-2589 ± 691 vs. -3115 ± 866mmHg/s, p = 0.50) and cardiac output (436 ± 28 vs. 481 ± 59ml/kg/min, p = 0.26) were not affected by TLV initiation. Left ventricular relaxation time constant (tau) slightly increased from 21.5 ± 3.3 to 24.9 ± 3.7ms (p = 0.03). Mean arterial systemic (48 ± 6 vs. 53 ± 7mmHg, p = 0.38) and pulmonary pressures (31.3 ± 2.5 vs. 30.4 ± 2.3mmHg, p = 0.61) were stable. As expected, the inspiratory phase of liquid cycling exhibited a small but significant effect on most variables (i.e. central venous pressure +2.6 ± 0.5mmHg, p = 0.001; LVEDP +1.18 ± 0.12mmHg, p<0.001). CONCLUSIONS: TLV was well tolerated in our neonatal lamb model of severe respiratory distress syndrome and had limited impact on left ventricle diastolic function when compared to conventional mechanical ventilation.
[Mh] Termos MeSH primário: Diástole
Modelos Animais de Doenças
Ventilação Líquida/métodos
Síndrome do Desconforto Respiratório do Recém-Nascido/terapia
Função Ventricular Esquerda
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Fluorcarbonetos/farmacocinética
Síndrome do Desconforto Respiratório do Recém-Nascido/fisiopatologia
Ovinos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Fluorocarbons); Q1D0Q7R4D9 (perflubron)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180130
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191885


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[PMID]:28457675
[Au] Autor:Wichgers Schreur PJ; van Keulen L; Kant J; Kortekaas J
[Ad] Endereço:Department of Virology, Wageningen Bioveterinary Research, Lelystad, The Netherlands. Electronic address: paul.wichgersschreur@wur.nl.
[Ti] Título:Four-segmented Rift Valley fever virus-based vaccines can be applied safely in ewes during pregnancy.
[So] Source:Vaccine;35(23):3123-3128, 2017 05 25.
[Is] ISSN:1873-2518
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Rift Valley fever virus (RVFV) causes severe and recurrent outbreaks on the African continent and the Arabian Peninsula and continues to expand its habitat. This mosquito-borne virus, belonging to the genus Phlebovirus of the family Bunyaviridae contains a tri-segmented negative-strand RNA genome. Previously, we developed four-segmented RVFV (RVFV-4s) variants by splitting the M-genome segment into two M-type segments each encoding one of the structural glycoproteins; Gn or Gc. Vaccination/challenge experiments with mice and lambs subsequently showed that RVFV-4s induces protective immunity against wild-type virus infection after a single administration. To demonstrate the unprecedented safety of RVFV-4s, we here report that the virus does not cause encephalitis after intranasal inoculation of mice. A study with pregnant ewes subsequently revealed that RVFV-4s does not cause viremia and does not cross the ovine placental barrier, as evidenced by the absence of teratogenic effects and virus in the blood and organs of the fetuses. Altogether, these results show that the RVFV-4s vaccine virus can be applied safely in pregnant ewes.
[Mh] Termos MeSH primário: Febre do Vale de Rift/prevenção & controle
Vírus da Febre do Vale do Rift/genética
Vírus da Febre do Vale do Rift/imunologia
Doenças dos Ovinos/prevenção & controle
Vacinas Virais/administração & dosagem
Vacinas Virais/efeitos adversos
[Mh] Termos MeSH secundário: Animais
Anticorpos Neutralizantes/sangue
Anticorpos Antivirais/sangue
Encefalite Viral/etiologia
Encefalite Viral/veterinária
Feminino
Genoma Viral/genética
Genoma Viral/imunologia
Camundongos
Gravidez
Febre do Vale de Rift/virologia
Vírus da Febre do Vale do Rift/química
Ovinos
Carneiro Doméstico/imunologia
Teratogênios
Vacinas Atenuadas/administração & dosagem
Vacinas Atenuadas/efeitos adversos
Vacinas Atenuadas/imunologia
Vacinas Virais/imunologia
Viremia/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Neutralizing); 0 (Antibodies, Viral); 0 (Teratogens); 0 (Vaccines, Attenuated); 0 (Viral Vaccines)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


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[PMID]:29406032
[Au] Autor:Doran GS; Smith AK; Rothwell JT; Edwards SH
[Ad] Endereço:Charles Sturt University, School of Agricultural and Wine Sciences, Wagga Wagga 2678, NSW, Australia; Graham Centre for Agricultural Innovation. Electronic address: gdoran@csu.edu.au.
[Ti] Título:Direct detection of glucuronide metabolites of lidocaine in sheep urine.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1076:84-90, 2018 Feb 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The anaesthetic lidocaine is metabolised quickly to produce a series of metabolites, including several hydroxylated metabolites, which are further metabolised by addition of a glucuronic acid moiety. Analysis of these glucuronide metabolites in urine is performed indirectly by cleaving the glucuronic acid group using ß-glucuronidase. However, direct analysis of intact glucuronide conjugates is a more straightforward approach as it negates the need for long hydrolysis incubations, and minimises the oxidation of sensitive hydrolysis products, while also distinguishing between the two forms of hydroxylated metabolites. A method was developed to identify three intact glucuronides of lidocaine in sheep urine using LC-MS/MS, which was further confirmed by the synthesis of glucuronide derivatives of 3OH-MEGX and 4OH-LIDO. Direct analysis of urine allowed the detection of the glucuronide metabolites of hydroxylidocaine (OH-LIDO), hydroxyl-monoethylglycinexylidide (OH-MEGX), and hydroxy-2,6-xylidine (OH-XYL). Analysis of urine before and after ß-glucuronidase digestion showed that the efficiency of hydrolysis of these glucuronide metabolites may be underestimated in some studies. Analysis of urine in the current study from three different sheep with similar glucuronide metabolite concentrations resulted in different hydrolysis efficiencies, which may have been a result of different levels of substrate binding by matrix components, preventing enzyme cleavage. The use of direct analysis of intact glucuronides has the benefit of being less influenced by these matrix effects, while also allowing analysis of unstable metabolites like 4OH-XYL, which rapidly oxidises after hydrolysis. Additionally, direct analysis is less expensive and less time consuming, while providing more information about the status of hydroxylated metabolites in urine.
[Mh] Termos MeSH primário: Cromatografia Líquida/métodos
Lidocaína/urina
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Animais
Glucuronídeos/química
Glucuronídeos/metabolismo
Glucuronídeos/urina
Concentração de Íons de Hidrogênio
Lidocaína/química
Lidocaína/metabolismo
Masculino
Ovinos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucuronides); 98PI200987 (Lidocaine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


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[PMID]:29246990
[Ti] Título:Mortality due to pulpy kidney in beef calves and goats.
[So] Source:Vet Rec;181(24):646-650, 2017 12 16.
[Is] ISSN:2042-7670
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Doenças dos Animais/epidemiologia
Surtos de Doenças/veterinária
Vigilância de Evento Sentinela/veterinária
[Mh] Termos MeSH secundário: Animais
Doenças das Aves/epidemiologia
Aves
Bovinos
Doenças dos Bovinos/epidemiologia
Doenças dos Bovinos/mortalidade
Feminino
Doenças das Cabras/epidemiologia
Doenças das Cabras/mortalidade
Cabras
Nefropatias/mortalidade
Nefropatias/veterinária
Aves Domésticas
Gravidez
Escócia/epidemiologia
Ovinos
Doenças dos Ovinos/epidemiologia
Suínos
Doenças dos Suínos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1136/vr.j5822


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[PMID]:29246991
[Ti] Título: type D enterotoxaemia in cattle, goats and sheep.
[So] Source:Vet Rec;181(24):648-649, 2017 12 16.
[Is] ISSN:2042-7670
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Doenças dos Bovinos/diagnóstico
Clostridium perfringens/isolamento & purificação
Enterotoxemia/diagnóstico
Doenças das Cabras/diagnóstico
Doenças dos Ovinos/diagnóstico
[Mh] Termos MeSH secundário: Animais
Toxinas Bacterianas/isolamento & purificação
Bovinos
Doenças dos Bovinos/microbiologia
Clostridium perfringens/classificação
Enterotoxemia/microbiologia
Conteúdo Gastrointestinal
Doenças das Cabras/microbiologia
Cabras
Vigilância de Evento Sentinela/veterinária
Ovinos
Doenças dos Ovinos/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Toxins)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1136/vr.j5823


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[PMID]:29188664
[Au] Autor:Lou XP; Zhang W; Zheng J; Xu H; Zhao F
[Ad] Endereço:Department of Forensic Medicine, Medical College of Nanchang University, Nanchang 330006, China.
[Ti] Título:[Comparative Study on Morphology of Human, Swine, Sheep and Cattle Muscle Tissues and Its Forensic Significance].
[So] Source:Fa Yi Xue Za Zhi;32(4):250-253, 2016 Aug.
[Is] ISSN:1004-5619
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVES: To observe the morphological characteristic indexes of the muscle tissues from different species and to establish a discriminant equation of species identification and tried to establish a new method for species identification. METHODS: Three different parts of the muscle tissues, triceps brachii, biceps femoris and erector spinae from adult human corpses, triceps brachii, biceps femoris and longissimus dorsi muscle from swine, sheep and cattle reached the slaughter age, were extracted respectively (20 for each group) and deal the tissues into paraffin sections. Eleven observational indexes of the muscle tissues from adult human corpses, swine, sheep and cattle were detected. Statistical methods were used to analyze the data and a discriminant equation of species identification was established. RESULTS: Four observation indicators were screened for establishing the discriminant equation of species identification among human, swine, sheep and cattle. The accurate rate of this method for human muscle tissue identification was 90%, and for swine, sheep, and cattle muscle tissue were 80%, 100% and 80% respectively. CONCLUSIONS: The morphological method provides a new method for the species identification of the muscle tissue among human, swine, sheep and cattle, and it can be used as a reference for the identification of animal species.
[Mh] Termos MeSH primário: Músculo Esquelético/anatomia & histologia
[Mh] Termos MeSH secundário: Animais
Cadáver
Bovinos
Antropologia Forense
Seres Humanos
Ovinos
Suínos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.3969/j.issn.1004-5619.2016.04.003


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[PMID]:28461086
[Au] Autor:Arando A; Gonzalez A; Delgado JV; Arrebola FA; Perez-Marín CC
[Ad] Endereço:Department of Genetics, Faculty of Veterinary Medicine, University of Cordoba, Cordoba 14014, Spain.
[Ti] Título:Storage temperature and sucrose concentrations affect ram sperm quality after vitrification.
[So] Source:Anim Reprod Sci;181:175-185, 2017 Jun.
[Is] ISSN:1873-2232
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to analyse the characteristics of ram spermatozoa subjected to varying concentrations of sucrose, and the influence of storage temperature (22°C or 5°C) prior to vitrification. Ejaculated semen was diluted in TCFEY (tris-citric acid-fructose 20% egg yolk), and two aliquots were prepared at a final concentration of 100×10 spz/ml, one maintained at room temperature (22°C) and the other at 5°C. In the first experiment, the toxicity of sucrose diluents on the sperm was analysed; sperm samples at different temperatures were diluted (1:2) in TCF-BSA 2% (control) or in the same extender supplemented with various sucrose concentrations (0.4M, 0.6M and 0.8M). The effects of vitrification were studied in the second experiment, where sperm samples were mixed with different concentrations of cryoprotectants (sucrose) and vitrified by being plunged directly into liquid nitrogen. In both experiments, the sperm quality was assessed by measuring motility, morphology, membrane functionality (HOST), viability, acrosome integrity and DNA fragmentation. The toxicity test revealed significant differences (p≤0.05) when different sucrose concentrations were used; lower total and progressive motility, normal morphology and membrane functionality were noted when sucrose concentration was higher, compared to the control treatment. Samples maintained at room temperature showed significantly (p≤0.05) higher viability than samples stored at 5°C. In contrast, although the quality of vitrified sperm was drastically decreased in comparison with fresh sperm, sucrose was associated with greater total motility, viability and membrane functionality. This improvement was closely linked to the temperature at which the sperm had been previously maintained, showing higher values when sperm was stored at 5°C. The main conclusions to be drawn from the study are therefore that sucrose shows promising potential as a cryoprotectant, and storing samples at 5°C is linked to improved sperm quality following vitrification.
[Mh] Termos MeSH primário: Análise do Sêmen/veterinária
Preservação do Sêmen/veterinária
Ovinos/fisiologia
Sacarose/farmacologia
[Mh] Termos MeSH secundário: Animais
Criopreservação
Crioprotetores/farmacologia
Fragmentação do DNA/efeitos dos fármacos
Masculino
Sêmen/efeitos dos fármacos
Contagem de Espermatozoides
Motilidade Espermática/efeitos dos fármacos
Temperatura Ambiente
Vitrificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cryoprotective Agents); 57-50-1 (Sucrose)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


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[PMID]:29254917
[Au] Autor:Zhao YX; Li MH
[Ad] Endereço:1. CAS Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; 2. University of Chinese Academy of Sciences, Beijing 100049, China.
[Ti] Título:Research advances on the origin, evolution and genetic diversity of Chinese native sheep breeds.
[So] Source:Yi Chuan;39(11):958-973, 2017 Nov 20.
[Is] ISSN:0253-9772
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:China has a rich resource of native sheep breeds, some of which possess specific traits such as prolificacy, excellent lamb pelts, multiple horns, fat tails and strong stress resistance. All these have been the focus of research. However, there is still a controversy about the origin of sheep breeds and a lack of comprehensive and systematic studies on genetic diversity of Chinese native sheep. In this review, we summarize recent research advances on the origin, evolution and genetic diversity of Chinese native sheep breeds based on paternal, maternal, and autosomal markers. This review will provide useful information for the conservation and utilization of sheep genetic resources, breeding of new sheep breeds and the sustainable development of Chinese sheep industry.
[Mh] Termos MeSH primário: Evolução Biológica
Variação Genética
Ovinos/genética
[Mh] Termos MeSH secundário: Animais
Cruzamento
Variações do Número de Cópias de DNA
DNA Mitocondrial/genética
Polimorfismo de Nucleotídeo Único
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (DNA, Mitochondrial)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE
[do] DOI:10.16288/j.yczz.17-102


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[PMID]:28449707
[Au] Autor:Llorens F; Thüne K; Sikorska B; Schmitz M; Tahir W; Fernández-Borges N; Cramm M; Gotzmann N; Carmona M; Streichenberger N; Michel U; Zafar S; Schuetz AL; Rajput A; Andréoletti O; Bonn S; Fischer A; Liberski PP; Torres JM; Ferrer I; Zerr I
[Ad] Endereço:Department of Neurology, University Medical Center Göttingen, and German Center for Neurodegenerative Diseases (DZNE), Robert Koch Strasse 40, 37075, Göttingen, Germany. franc.llorens@gmail.com.
[Ti] Título:Altered Ca homeostasis induces Calpain-Cathepsin axis activation in sporadic Creutzfeldt-Jakob disease.
[So] Source:Acta Neuropathol Commun;5(1):35, 2017 04 27.
[Is] ISSN:2051-5960
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Sporadic Creutzfeldt-Jakob disease (sCJD) is the most prevalent form of human prion disease and it is characterized by the presence of neuronal loss, spongiform degeneration, chronic inflammation and the accumulation of misfolded and pathogenic prion protein (PrP ). The molecular mechanisms underlying these alterations are largely unknown, but the presence of intracellular neuronal calcium (Ca ) overload, a general feature in models of prion diseases, is suggested to play a key role in prion pathogenesis.Here we describe the presence of massive regulation of Ca responsive genes in sCJD brain tissue, accompanied by two Ca -dependent processes: endoplasmic reticulum stress and the activation of the cysteine proteases Calpains 1/2. Pathogenic Calpain proteins activation in sCJD is linked to the cleavage of their cellular substrates, impaired autophagy and lysosomal damage, which is partially reversed by Calpain inhibition in a cellular prion model. Additionally, Calpain 1 treatment enhances seeding activity of PrP in a prion conversion assay. Neuronal lysosomal impairment caused by Calpain over activation leads to the release of the lysosomal protease Cathepsin S that in sCJD mainly localises in axons, although massive Cathepsin S overexpression is detected in microglial cells. Alterations in Ca homeostasis and activation of Calpain-Cathepsin axis already occur at pre-clinical stages of the disease as detected in a humanized sCJD mouse model.Altogether our work indicates that unbalanced Calpain-Cathepsin activation is a relevant contributor to the pathogenesis of sCJD at multiple molecular levels and a potential target for therapeutic intervention.
[Mh] Termos MeSH primário: Encéfalo/metabolismo
Cálcio/metabolismo
Calpaína/metabolismo
Catepsinas/metabolismo
Síndrome de Creutzfeldt-Jakob/metabolismo
Homeostase/fisiologia
[Mh] Termos MeSH secundário: Animais
Encéfalo/patologia
Cátions Bivalentes/metabolismo
Células Cultivadas
Síndrome de Creutzfeldt-Jakob/patologia
Modelos Animais de Doenças
Seres Humanos
Lisossomos/metabolismo
Lisossomos/patologia
Mesocricetus
Camundongos Transgênicos
Neurônios/metabolismo
Neurônios/patologia
Proteínas PrPSc/metabolismo
Ratos Wistar
Proteínas Recombinantes/metabolismo
Ovinos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cations, Divalent); 0 (PrPSc Proteins); 0 (Recombinant Proteins); EC 3.4.- (Cathepsins); EC 3.4.22.- (Calpain); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1186/s40478-017-0431-y



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