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[PMID]:28708832
[Au] Autor:Butler CJ; Edwards WH; Jennings-Gaines JE; Killion HJ; Wood ME; McWhirter DE; Paterson JT; Proffitt KM; Almberg ES; White PJ; Rotella JJ; Garrott RA
[Ad] Endereço:Fish and Wildlife Ecology and Management Program, Department of Ecology, Montana State University, Bozeman, Montana, United States of America.
[Ti] Título:Assessing respiratory pathogen communities in bighorn sheep populations: Sampling realities, challenges, and improvements.
[So] Source:PLoS One;12(7):e0180689, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Respiratory disease has been a persistent problem for the recovery of bighorn sheep (Ovis canadensis), but has uncertain etiology. The disease has been attributed to several bacterial pathogens including Mycoplasma ovipneumoniae and Pasteurellaceae pathogens belonging to the Mannheimia, Bibersteinia, and Pasteurella genera. We estimated detection probability for these pathogens using protocols with diagnostic tests offered by a fee-for-service laboratory and not offered by a fee-for-service laboratory. We conducted 2861 diagnostic tests on swab samples collected from 476 bighorn sheep captured across Montana and Wyoming to gain inferences regarding detection probability, pathogen prevalence, and the power of different sampling methodologies to detect pathogens in bighorn sheep populations. Estimated detection probability using fee-for-service protocols was less than 0.50 for all Pasteurellaceae and 0.73 for Mycoplasma ovipneumoniae. Non-fee-for-service Pasteurellaceae protocols had higher detection probabilities, but no single protocol increased detection probability of all Pasteurellaceae pathogens to greater than 0.50. At least one protocol resulted in an estimated detection probability of 0.80 for each pathogen except Mannheimia haemolytica, for which the highest detection probability was 0.45. In general, the power to detect Pasteurellaceae pathogens at low prevalence in populations was low unless many animals were sampled or replicate samples were collected per animal. Imperfect detection also resulted in low precision when estimating prevalence for any pathogen. Low and variable detection probabilities for respiratory pathogens using live-sampling protocols may lead to inaccurate conclusions regarding pathogen community dynamics and causes of bighorn sheep respiratory disease epizootics. We recommend that agencies collect multiples samples per animal for Pasteurellaceae detection, and one sample for Mycoplasma ovipneumoniae detection from at least 30 individuals to reliably detect both Pasteurellaceae and Mycoplasma ovipneumoniae at the population-level. Availability of PCR diagnostic tests to wildlife management agencies would improve the ability to reliably detect Pasteurellaceae in bighorn sheep populations.
[Mh] Termos MeSH primário: Infecções Respiratórias/diagnóstico
Doenças dos Ovinos/diagnóstico
[Mh] Termos MeSH secundário: Animais
DNA Bacteriano/metabolismo
Mycoplasma ovipneumoniae/genética
Mycoplasma ovipneumoniae/isolamento & purificação
Pasteurellaceae/genética
Pasteurellaceae/isolamento & purificação
Densidade Demográfica
Prevalência
Reação em Cadeia da Polimerase em Tempo Real
Infecções Respiratórias/epidemiologia
Infecções Respiratórias/microbiologia
Ovinos
Doenças dos Ovinos/epidemiologia
Doenças dos Ovinos/microbiologia
Carneiro da Montanha
Manejo de Espécimes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180689


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[PMID]:28591169
[Au] Autor:Besser TE; Cassirer EF; Potter KA; Foreyt WJ
[Ad] Endereço:Department of Veterinary Microbiology and Pathology, Washington State University College of Veterinary Medicine, Pullman, WA, United States of America.
[Ti] Título:Exposure of bighorn sheep to domestic goats colonized with Mycoplasma ovipneumoniae induces sub-lethal pneumonia.
[So] Source:PLoS One;12(6):e0178707, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Bronchopneumonia is a population limiting disease of bighorn sheep (Ovis canadensis) that has been associated with contact with domestic Caprinae. The disease is polymicrobial but is initiated by Mycoplasma ovipneumoniae, which is commonly carried by both domestic sheep (O. aries) and goats (Capra aegagrus hircus). However, while previous bighorn sheep comingling studies with domestic sheep have resulted in nearly 100% pneumonia mortality, only sporadic occurrence of fatal pneumonia was reported from previous comingling studies with domestic goats. Here, we evaluated the ability of domestic goats of defined M. ovipneumoniae carriage status to induce pneumonia in comingled bighorn sheep. METHODOLOGY/PRINCIPAL FINDINGS: In experiment 1, three bighorn sheep naïve to M. ovipneumoniae developed non-fatal respiratory disease (coughing, nasal discharge) following comingling with three naturally M. ovipneumoniae-colonized domestic goats. Gross and histological lesions of pneumonia, limited to small areas on the ventral and lateral edges of the anterior and middle lung lobes, were observed at necropsies conducted at the end of the experiment. A control group of three bighorn sheep from the same source housed in isolation during experiment 1 remained free of observed respiratory disease. In experiment 2, three bighorn sheep remained free of observed respiratory disease while comingled with three M. ovipneumoniae-free domestic goats. In experiment 3, introduction of a domestic goat-origin strain of M. ovipneumoniae to the same comingled goats and bighorn sheep used in experiment 2 resulted in clinical signs of respiratory disease (coughing, nasal discharge) in both host species. At the end of experiment 3, gross and histological evidence of pneumonia similar to that observed in experiment 1 bighorn sheep was observed in both affected bighorn sheep and domestic goats. CONCLUSIONS/SIGNIFICANCE: M. ovipneumoniae strains carried by domestic goats were transmitted to comingled bighorn sheep, triggering development of pneumonia. However, the severity of the disease was markedly milder than that seen in similar experiments with domestic sheep strains of the bacterium.
[Mh] Termos MeSH primário: Animais Domésticos/microbiologia
Cabras/microbiologia
Mycoplasma ovipneumoniae/fisiologia
Pneumonia por Mycoplasma/veterinária
Carneiro da Montanha/microbiologia
[Mh] Termos MeSH secundário: Animais
Pulmão/microbiologia
Pulmão/patologia
Pneumonia por Mycoplasma/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178707


  3 / 133 MEDLINE  
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[PMID]:28424347
[Au] Autor:Pigeon G; Festa-Bianchet M; Pelletier F
[Ad] Endereço:Département de Biologie, Université de Sherbrooke, 2500 boulevard de l'Université, Sherbrooke, Québec, Canada J1 K 2R1 gabriel.pigeon@usherbrooke.ca.
[Ti] Título:Long-term fitness consequences of early environment in a long-lived ungulate.
[So] Source:Proc Biol Sci;284(1853), 2017 Apr 26.
[Is] ISSN:1471-2954
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Cohort effects can be a major source of heterogeneity and play an important role in population dynamics. Silver-spoon effects, when environmental quality at birth improves future performance regardless of the adult environment, can induce strong lagged responses on population growth. Alternatively, the external predictive adaptive response (PAR) hypothesis predicts that organisms will adjust their developmental trajectory and physiology during early life in anticipation of expected adult conditions but has rarely been assessed in wild species. We used over 40 years of detailed individual monitoring of bighorn ewes ( ) to quantify long-term cohort effects on survival and reproduction. We then tested both the silver-spoon and the PAR hypotheses. Cohort effects involved a strong interaction between birth and current environments: reproduction and survival were lowest for ewes that were born and lived at high population densities. This interaction, however, does not support the PAR hypothesis because individuals with matching high-density birth and adult environments had reduced fitness. Instead, individuals born at high density had overall lower lifetime fitness suggesting a silver-spoon effect. Early-life conditions can induce long-term changes in fitness components, and their effects on cohort fitness vary according to adult environment.
[Mh] Termos MeSH primário: Reprodução/fisiologia
Carneiro da Montanha/fisiologia
[Mh] Termos MeSH secundário: Alberta
Animais
Feminino
Aptidão Genética
Modelos Teóricos
Densidade Demográfica
Dinâmica Populacional
Taxa de Sobrevida
Desmame
Tempo (Meteorologia)
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170622
[Lr] Data última revisão:
170622
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170421
[St] Status:MEDLINE


  4 / 133 MEDLINE  
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[PMID]:28282407
[Au] Autor:Drew ML; Weiser GC
[Ad] Endereço:Wildlife Health Laboratory, Idaho Department of Fish and Game, Eagle, Idaho, United States of America.
[Ti] Título:Potential disease agents in domestic goats and relevance to bighorn sheep (Ovis canadensis) management.
[So] Source:PLoS One;12(3):e0173396, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Domestic goats are raised for meat, milk and hair production, in herds for rangeland weed control, and as pack animals. Domestic sheep, goats and wild bighorn sheep are all susceptible to a multifactorial pneumonia. We sampled 43 herd goats from 7 herds and 48 pack goats from 11 herds for viral and bacterial serology, parasitology, and Pasteurellaceae microbiology. The goats in this study were in generally good health, although most goats did harbor various pathogens and parasites including several bacteria, specifically Pasteurellaceae, which have been associated with pneumonia in free-ranging bighorn sheep. It is not known if domestic goats can transmit the Pasteurellaceae or other pathogens found in this study readily to wild bighorn sheep. However, due the possibility of transmission, domestic goats in areas in or near bighorn sheep habitat should be managed to minimize the risk of spreading disease agents to bighorn sheep.
[Mh] Termos MeSH primário: Cabras/microbiologia
Ovinos/microbiologia
[Mh] Termos MeSH secundário: Animais
Animais Domésticos
Anticorpos Antivirais/sangue
Ecossistema
Fezes/parasitologia
Doenças das Cabras/microbiologia
Doenças das Cabras/parasitologia
Doenças das Cabras/virologia
Cabras/parasitologia
Cabras/virologia
Pasteurellaceae/isolamento & purificação
Ovinos/parasitologia
Ovinos/virologia
Doenças dos Ovinos/microbiologia
Doenças dos Ovinos/parasitologia
Doenças dos Ovinos/virologia
Carneiro da Montanha/microbiologia
Carneiro da Montanha/parasitologia
Carneiro da Montanha/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0173396


  5 / 133 MEDLINE  
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[PMID]:27793720
[Au] Autor:Johnson KL; Trim MW; Francis DK; Whittington WR; Miller JA; Bennett CE; Horstemeyer MF
[Ad] Endereço:Department of Mechanical Engineering, Mississippi State University, Mississippi State, MS 39762, USA; Center for Advanced Vehicular Systems (CAVS), 200 Research Blvd, Mississippi State, MS 39762, USA. Electronic address: kljohnsonmsu@gmail.com.
[Ti] Título:Moisture, anisotropy, stress state, and strain rate effects on bighorn sheep horn keratin mechanical properties.
[So] Source:Acta Biomater;48:300-308, 2017 Jan 15.
[Is] ISSN:1878-7568
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This paper investigates the effects of moisture, anisotropy, stress state, and strain rate on the mechanical properties of the bighorn sheep (Ovis Canadensis) horn keratin. The horns consist of fibrous keratin tubules extending along the length of the horn and are contained within an amorphous keratin matrix. Samples were tested in the rehydrated (35wt% water) and ambient dry (10wt% water) conditions along the longitudinal and radial directions under tension and compression. Increased moisture content was found to increase ductility and decrease strength, as well as alter the stress state dependent nature of the material. The horn keratin demonstrates a significant strain rate dependence in both tension and compression, and also showed increased energy absorption in the hydrated condition at high strain rates when compared to quasi-static data, with increases of 114% in tension and 192% in compression. Compressive failure occurred by lamellar buckling in the longitudinal orientation followed by shear delamination. Tensile failure in the longitudinal orientation occurred by lamellar delamination combined with tubule pullout and fracture. The structure-property relationships quantified here for bighorn sheep horn keratin can be used to help validate finite element simulations of ram's impacting each other as well as being useful for other analysis regarding horn keratin on other animals. STATEMENT OF SIGNIFICANCE: The horn of the bighorn sheep is an anisotropic composite composed of keratin that is highly sensitive to moisture content. Keratin is also found in many other animals in the form of hooves, claws, beaks, and feathers. Only one previous study contains high rate experimental data, which was performed in the dry condition and only in compression. Considering the bighorn sheep horns' protective role in high speed impacts along with the moisture and strain rate sensitivity, more high strain rate data is needed to fully characterize and model the material. This study provides high strain rate results demonstrating the effects of moisture, anisotropy, and stress state. As a result, the comprehensive data allows modeling efforts to be greatly improved.
[Mh] Termos MeSH primário: Cornos/química
Umidade
Queratinas/química
Estresse Mecânico
[Mh] Termos MeSH secundário: Animais
Anisotropia
Fenômenos Biomecânicos
Força Compressiva
Cornos/ultraestrutura
Processamento de Imagem Assistida por Computador
Carneiro da Montanha
Estatística como Assunto
Resistência à Tração
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
68238-35-7 (Keratins)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161107
[St] Status:MEDLINE


  6 / 133 MEDLINE  
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[PMID]:27544811
[Au] Autor:Drake A; Haut Donahue TL; Stansloski M; Fox K; Wheatley BB; Donahue SW
[Ad] Endereço:Department of Mechanical Engineering, Colorado State University, 300 West Drake Rd, Fort Collins, C0 80526, United States.
[Ti] Título:Horn and horn core trabecular bone of bighorn sheep rams absorbs impact energy and reduces brain cavity accelerations during high impact ramming of the skull.
[So] Source:Acta Biomater;44:41-50, 2016 10 15.
[Is] ISSN:1878-7568
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:UNLABELLED: Bighorn sheep (Ovis canadensis) routinely experience violent impacts to the head as part of intraspecific fighting. Dynamic 3D finite element models of the skull and horns of a male bighorn sheep were developed to gain an understanding of the roles that the horn and bone materials and structure play in absorbing the impact that occurs during ramming. The geometry and volume mesh of the model were derived from CT scan images. The models included the horn, bony horn core, and bone of the skull. The horn core fills a portion of the hollow horn and consists of a thin cortical bone shell filled with foam-like trabecular bone. Two modified models were also created: one with the distal half of the horn length removed to assess the effects of the tapered spiral geometry of the horn, and one with the internal trabecular bone material of the horn core removed. The trabecular bone material stored three times more strain energy during impact than the horn material in the intact model. Removing half of the horn length had the effect of increasing translational accelerations in the brain cavity by 49%. Removing the trabecular bone in the horn core resulted in a 442% increase in rotational accelerations within the brain cavity. These findings support the investigation of novel bioinspired materials and designs that could be used in mitigating brain injuries and in other applications involving high-impact collisions. STATEMENT OF SIGNIFICANCE: Bighorn sheep routinely experience violent impacts to the head and horns without apparent negative consequences to the brain or horns. A portion of the horn is filled with a thin cortical bone shell containing foam-like trabecular bone. We developed novel dynamic finite element models of the skull and horns of bighorn sheep to gain an understanding of the roles that the horn and bone materials play in absorbing the impact that occurs during ramming. The study revealed that both horn and bone materials and the structures made from these materials (i.e., tapered spiral horns and foam-like trabecular bone struts) are important for absorbing impact energy and reducing brain cavity accelerations.
[Mh] Termos MeSH primário: Aceleração
Encéfalo/fisiologia
Osso Esponjoso/fisiologia
Cornos/fisiologia
Crânio/fisiologia
[Mh] Termos MeSH secundário: Animais
Análise de Elementos Finitos
Masculino
Reprodutibilidade dos Testes
Rotação
Carneiro da Montanha
Estresse Mecânico
Vibração
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171120
[Lr] Data última revisão:
171120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160822
[St] Status:MEDLINE


  7 / 133 MEDLINE  
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[PMID]:27269790
[Au] Autor:Batra SA; Shanthalingam S; Donofrio G; Srikumaran S
[Ad] Endereço:Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040, USA.
[Ti] Título:A chimeric protein comprising the immunogenic domains of Mannheimia haemolytica leukotoxin and outer membrane protein PlpE induces antibodies against leukotoxin and PlpE.
[So] Source:Vet Immunol Immunopathol;175:36-41, 2016 Jul.
[Is] ISSN:1873-2534
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Mannheimia haemolytica is a very important pathogen of pneumonia in ruminants. Bighorn sheep (BHS, Ovis canadensis) are highly susceptible to M. haemolytica-caused pneumonia which has significantly contributed to the drastic decline of bighorn sheep population in North America. Pneumonia outbreaks in wild BHS can cause mortality as high as 90%. Leukotoxin is the critical virulence factor of M. haemolytica. In a 'proof of concept' study, an experimental vaccine containing leukotoxin and surface antigens of M. haemolytica developed by us induced 100% protection of BHS, but required multiple booster injections. Vaccination of wild BHS is difficult. But they can be vaccinated at the time of transplantation into a new habitat. Administration of booster doses, however, is impossible. Therefore, a vaccine that does not require booster doses is necessary to immunize BHS against M. haemolytica pneumonia. Herpesviruses are ideal vectors for development of such a vaccine because of their ability to undergo latency with subsequent reactivation. As the first step towards developing a herpesvirus-vectored vaccine, we constructed a chimeric protein comprising the leukotoxin-neutralizing epitopes and the immuno-dominant epitopes of the outer membrane protein PlpE. The chimeric protein was efficiently expressed in primary BHS lung cells. The immunogenicity of the chimeric protein was evaluated in mice before inoculating BHS. Mice immunized with the chimeric protein developed antibodies against M. haemolytica leukotoxin and PlpE. More importantly, the anti-leukotoxin antibodies effectively neutralized leukotoxin-induced cytotoxicity. Taken together, these results represent the successful completion of the first step towards developing a herpesvirus-vectored vaccine for controlling M. haemolytica pneumonia in BHS, and possibly other ruminants.
[Mh] Termos MeSH primário: Proteínas da Membrana Bacteriana Externa/imunologia
Exotoxinas/imunologia
Mannheimia haemolytica/imunologia
Mannheimia haemolytica/patogenicidade
Doenças dos Ovinos/imunologia
Doenças dos Ovinos/microbiologia
Carneiro da Montanha/imunologia
Carneiro da Montanha/microbiologia
[Mh] Termos MeSH secundário: Animais
Anticorpos Antibacterianos/biossíntese
Anticorpos Neutralizantes/biossíntese
Especificidade de Anticorpos
Proteínas da Membrana Bacteriana Externa/química
Proteínas da Membrana Bacteriana Externa/genética
Vacinas Bacterianas/genética
Vacinas Bacterianas/imunologia
Exotoxinas/química
Exotoxinas/genética
Feminino
Vetores Genéticos
Herpesviridae/genética
Mannheimia haemolytica/genética
Camundongos
Camundongos Endogâmicos BALB C
Pasteurelose Pneumônica/imunologia
Pasteurelose Pneumônica/microbiologia
Pasteurelose Pneumônica/prevenção & controle
Proteínas Recombinantes de Fusão/química
Proteínas Recombinantes de Fusão/genética
Proteínas Recombinantes de Fusão/imunologia
Ovinos
Doenças dos Ovinos/prevenção & controle
Vacinas Sintéticas/genética
Vacinas Sintéticas/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Bacterial); 0 (Antibodies, Neutralizing); 0 (Bacterial Outer Membrane Proteins); 0 (Bacterial Vaccines); 0 (Exotoxins); 0 (Recombinant Fusion Proteins); 0 (Vaccines, Synthetic); 0 (leukotoxin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170410
[Lr] Data última revisão:
170410
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160609
[St] Status:MEDLINE


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[PMID]:27260809
[Au] Autor:Highland MA; Schneider DA; White SN; Madsen-Bouterse SA; Knowles DP; Davis WC
[Ad] Endereço:Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164-7040, USA; Animal Disease Research Unit, United States Department of Agriculture, Pullman, WA 99164-6630, USA. Electronic address: Maggie.Highland@ARS.USDA.GOV.
[Ti] Título:Differences in leukocyte differentiation molecule abundances on domestic sheep (Ovis aries) and bighorn sheep (Ovis canadensis) neutrophils identified by flow cytometry.
[So] Source:Comp Immunol Microbiol Infect Dis;46:40-6, 2016 Jun.
[Is] ISSN:1878-1667
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Although both domestic sheep (DS) and bighorn sheep (BHS) are affected by similar respiratory bacterial pathogens, experimental and field data indicate BHS are more susceptible to pneumonia. Cross-reactive monoclonal antibodies (mAbs) for use in flow cytometry (FC) are valuable reagents for interspecies comparative immune system analyses. This study describes cross-reactive mAbs that recognize leukocyte differentiation molecules (LDMs) and major histocompatibility complex antigens on DS and BHS leukocytes. Characterization of multichannel eosinophil autofluorescence in this study permitted cell-type specific gating of granulocytes for evaluating LDMs, specifically on neutrophils, by single-label FC. Evaluation of relative abundances of LDMs by flow cytometry revealed greater CD11a, CD11b, CD18 (ß2 integrins) and CD 172a (SIRPα) on DS neutrophils and greater CD14 (lipopolysaccharide receptor) on BHS neutrophils. Greater CD25 (IL-2) was identified on BHS lymphocytes following Concavalin A stimulation. While DS and BHS have similar total peripheral blood leukocyte counts, BHS have proportionately more neutrophils.
[Mh] Termos MeSH primário: Antígenos CD/análise
Leucócitos/imunologia
Neutrófilos/imunologia
Carneiro da Montanha/imunologia
Carneiro Doméstico/imunologia
[Mh] Termos MeSH secundário: Animais
Anticorpos Monoclonais/imunologia
Antígenos CD/imunologia
Citometria de Fluxo
Subunidade alfa de Receptor de Interleucina-2/imunologia
Contagem de Leucócitos
Leucócitos/fisiologia
Receptores de Lipopolissacarídeos/imunologia
Ativação Linfocitária
Ovinos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (Antigens, CD); 0 (Interleukin-2 Receptor alpha Subunit); 0 (Lipopolysaccharide Receptors)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160605
[St] Status:MEDLINE


  9 / 133 MEDLINE  
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[PMID]:27020536
[Au] Autor:Fox KA; Wootton S; Marolf A; Rouse N; LeVan I; Spraker T; Miller M; Quackenbush S
[Ad] Endereço:Colorado Division of Parks and Wildlife, Wildlife Health Program, Fort Collins, CO, USA Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA karen.fox@state.co.us.
[Ti] Título:Experimental Transmission of Bighorn Sheep Sinus Tumors to Bighorn Sheep (Ovis canadensis canadensis) and Domestic Sheep.
[So] Source:Vet Pathol;53(6):1164-1171, 2016 Nov.
[Is] ISSN:1544-2217
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bighorn sheep sinus tumors are a recently described disease affecting the paranasal sinuses of Rocky Mountain bighorn sheep (Ovis canadensis canadensis). Several features of this disease suggest an infectious cause, although a specific etiologic agent has not been identified. To test the hypothesis that bighorn sheep sinus tumors are caused by an infectious agent, we inoculated 4 bighorn sheep lambs and 4 domestic sheep lambs intranasally with a cell-free filtrate derived from a naturally occurring bighorn sheep sinus tumor; we held 1 individual of each species as a control. Within 18 months after inoculation, all 4 inoculated domestic sheep (100%) and 1 of the 4 inoculated bighorn sheep (25%) developed tumors within the ethmoid sinuses or nasal conchae, with features similar to naturally occurring bighorn sheep sinus tumors. Neither of the uninoculated sheep developed tumors. Histologically, the experimentally transmitted tumors were composed of stellate to spindle cells embedded within a myxoid matrix, with marked bone production. Tumor cells stained positively with vimentin, S100, alpha smooth muscle actin, and osteocalcin, suggesting origin from a multipotent mesenchymal cell. A periosteal origin for these tumors is suspected. Immunohistochemical staining for the envelope protein of JSRV (with cross-reactivity to ENTV) was equivocal, and PCR assays specific for these agents were negative.
[Mh] Termos MeSH primário: Neoplasias dos Seios Paranasais/veterinária
Doenças dos Ovinos/transmissão
[Mh] Termos MeSH secundário: Animais
Feminino
Masculino
Neoplasias dos Seios Paranasais/diagnóstico por imagem
Neoplasias dos Seios Paranasais/etiologia
Neoplasias dos Seios Paranasais/patologia
Seios Paranasais/patologia
Ovinos
Doenças dos Ovinos/diagnóstico por imagem
Doenças dos Ovinos/etiologia
Doenças dos Ovinos/patologia
Carneiro da Montanha
Carneiro Doméstico
Tomografia Computadorizada por Raios X/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160330
[St] Status:MEDLINE


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[PMID]:26845295
[Au] Autor:Wolfe LL; Miller MW
[Ad] Endereço:1 Colorado Division of Parks and Wildlife, Wildlife Health Program, 4330 Laporte Avenue, Fort Collins, Colorado 80521-2153, USA.
[Ti] Título:USING TAILORED TRANQUILIZER COMBINATIONS TO REDUCE STRESS ASSOCIATED WITH LARGE UNGULATE CAPTURE AND TRANSLOCATION.
[So] Source:J Wildl Dis;52(2 Suppl):S118-24, 2016 Apr.
[Is] ISSN:1943-3700
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Capture and translocation are important tools for managing and studying large ungulates. Although widely used, many established field practices cause fear and stress in subject animals that can hamper overall effectiveness and safety. Over the last 10 years we have been exploring uses of tranquilizer combinations as adjuncts to wild ungulate capture and translocation work in Colorado, USA. Our approaches have been tailored to various field applications to reduce fear and stress, facilitate handling, and improve the overall success of capture and translocation for research or management purposes. For physical capture (drop net or helicopter-net gunning) with local release, combinations of midazolam and azaperone administered immediately upon capture provide transient tranquilization and muscle relaxation during manual restraint and handling to prevent hyperthermia and capture myopathy. For extended tranquilization (during transport and overnight holding), adding a sustained-release haloperidol formulation provides calming effects for at least 24-48 h. In our assessment, appropriate and adaptive use of these tranquilizer combinations benefits captured animals without impeding management or research goals.
[Mh] Termos MeSH primário: Cervos
Doenças dos Ovinos/prevenção & controle
Carneiro da Montanha
Estresse Fisiológico/efeitos dos fármacos
Estresse Psicológico/prevenção & controle
Tranquilizantes/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Azaperona/administração & dosagem
Colorado
Preparações de Ação Retardada
Combinação de Medicamentos
Feminino
Haloperidol/administração & dosagem
Masculino
Midazolam/administração & dosagem
Ovinos
Estresse Psicológico/etiologia
Transportes
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Delayed-Action Preparations); 0 (Drug Combinations); 0 (Tranquilizing Agents); 19BV78AK7W (Azaperone); J6292F8L3D (Haloperidol); R60L0SM5BC (Midazolam)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160205
[St] Status:MEDLINE
[do] DOI:10.7589/52.2S.S118



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