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  1 / 1056 MEDLINE  
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[PMID]:28804950
[Au] Autor:Sarmah J; Hazarika CR; Berkeley EV; Ganswindt SB; Ganswindt A
[Ad] Endereço:Bodoland University, Kokrajhar, Assam.
[Ti] Título:Non-invasive assessment of adrenocortical function as a measure of stress in the endangered golden langur.
[So] Source:Zoo Biol;36(4):278-283, 2017 Jul.
[Is] ISSN:1098-2361
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The golden langur (Trachypithecus geei) is an endangered primate endemic to northern India and Bhutan. The main stressors to the species are habitat degradation and fragmentation. Non-invasive fecal glucocorticoid metabolite (fGCM) analysis is a powerful tool for assessing stress associated with environmental disturbances in wildlife. However, interspecific differences in glucocorticoid metabolism require careful selection of the antibody used in their quantification. The goals of this study were to: 1) validate an enzyme immunoassay (EIA) to determine fecal GC metabolite (fGCM) concentrations in the golden langur and 2) compare fGCM concentrations between golden langurs living under different environmental conditions. We compared five enzyme immunoassays for determining stress related physiological responses in golden langurs by performing an adrenocorticotropic stimulation test in both sexes. Our validations identified an 11-oxoaetiocholanolone EIA detecting 11, 17 dioxoandrostanes as the most suitable assay for monitoring adrenocortical activity in the species. FGCM concentrations from semi-captive temple langurs were significantly higher than respective stress steroid concentrations in free-ranging or pet/zoo langurs. This study presents a validated practical method for non-invasive monitoring of adrenocortical function in this rare and declining species.
[Mh] Termos MeSH primário: Cercopithecidae/fisiologia
Espécies em Perigo de Extinção
Glucocorticoides/química
Glucocorticoides/metabolismo
[Mh] Termos MeSH secundário: Hormônio Adrenocorticotrópico/administração & dosagem
Animais
Fezes/química
Feminino
Técnicas Imunoenzimáticas/veterinária
Masculino
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucocorticoids); 9002-60-2 (Adrenocorticotropic Hormone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170815
[St] Status:MEDLINE
[do] DOI:10.1002/zoo.21369


  2 / 1056 MEDLINE  
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[PMID]:28389720
[Au] Autor:Dasmeh P; Kepp KP
[Ad] Endereço:Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
[Ti] Título:Superoxide dismutase 1 is positively selected to minimize protein aggregation in great apes.
[So] Source:Cell Mol Life Sci;74(16):3023-3037, 2017 Aug.
[Is] ISSN:1420-9071
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Positive (adaptive) selection has recently been implied in human superoxide dismutase 1 (SOD1), a highly abundant antioxidant protein with energy signaling and antiaging functions, one of very few examples of direct selection on a human protein product (exon); the molecular drivers of this selection are unknown. We mapped 30 extant SOD1 sequences to the recently established mammalian species tree and inferred ancestors, key substitutions, and signatures of selection during the protein's evolution. We detected elevated substitution rates leading to great apes (Hominidae) at ~1 per 2 million years, significantly higher than in other primates and rodents, although these paradoxically generally evolve much faster. The high evolutionary rate was partly due to relaxation of some selection pressures and partly to distinct positive selection of SOD1 in great apes. We then show that higher stability and net charge and changes at the dimer interface were selectively introduced upon separation from old world monkeys and lesser apes (gibbons). Consequently, human, chimpanzee and gorilla SOD1s have a net charge of -6 at physiological pH, whereas the closely related gibbons and macaques have -3. These features consistently point towards selection against the malicious aggregation effects of elevated SOD1 levels in long-living great apes. The findings mirror the impact of human SOD1 mutations that reduce net charge and/or stability and cause ALS, a motor neuron disease characterized by oxidative stress and SOD1 aggregates and triggered by aging. Our study thus marks an example of direct selection for a particular chemical phenotype (high net charge and stability) in a single human protein with possible implications for the evolution of aging.
[Mh] Termos MeSH primário: Hominidae/genética
Agregados Proteicos
Superóxido Dismutase-1/química
Superóxido Dismutase-1/genética
[Mh] Termos MeSH secundário: Envelhecimento
Sequência de Aminoácidos
Animais
Cercopithecidae/genética
Estabilidade Enzimática
Evolução Molecular
Seres Humanos
Hylobatidae/genética
Camundongos
Modelos Moleculares
Estresse Oxidativo
Filogenia
Platirrinos/genética
Ratos
Alinhamento de Sequência
Superóxido Dismutase-1/metabolismo
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Protein Aggregates); EC 1.15.1.1 (Superoxide Dismutase-1)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170409
[St] Status:MEDLINE
[do] DOI:10.1007/s00018-017-2519-8


  3 / 1056 MEDLINE  
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[PMID]:28278215
[Au] Autor:Clink DJ; Dillis C; Feilen KL; Beaudrot L; Marshall AJ
[Ad] Endereço:Department of Anthropology, University of California-Davis, Davis, California, United States of America.
[Ti] Título:Dietary diversity, feeding selectivity, and responses to fruit scarcity of two sympatric Bornean primates (Hylobates albibarbis and Presbytis rubicunda rubida).
[So] Source:PLoS One;12(3):e0173369, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Effectively characterizing primate diets is fundamental to understanding primate behavior, ecology and morphology. Examining temporal variation in a species' diet, as well as comparing the responses of different species to variation in resource availability, can enhance understanding of the evolution of morphology and socioecology. In this study, we use feeding data collected over five years to describe the diets of two sympatric Southeast Asian primate species of similar body size: white-bearded gibbons (Hylobates albibarbis) and red leaf monkeys (Presbytis rubicunda rubida), in Gunung Palung National Park, West Kalimantan, Indonesia. Long-term data sets are especially important for characterizing primate diets in Southeast Asia, where the forests exhibit supra-annual mast fruiting events. We found that gibbons were mainly frugivorous, with fruit and figs comprising 70% of their 145 independent feeding observations, whereas leaf monkeys ate a substantial amount of seeds (26%), fruits and figs (26.5%) and leaves (30%, n = 219 independent feeding observations). Leaf monkeys consumed a higher number of plant genera, and this was due mostly to the non-frugivorous portion of their diet. To investigate resource selection by these primates we utilized two different approaches: the Manly Selectivity Ratio, which did not take into account temporal variation of resource availability, and a model selection framework which did incorporate temporal variation. Both species selected figs (Ficus) more than predicted based on their availability under the Manly Selectivity Ratio. Model selection allowed us to determine how these primates alter the proportion of leaves, flowers, seeds, figs and fruit in their diets in response to variation in fruit availability. When fruits were scarce, both gibbons and leaf monkeys incorporated more leaves and figs into their diets, indicating that these two food classes are fallback foods for these primates. We discuss how different measures of resource selection can provide seemingly contradictory results, and emphasize the importance of long term studies that combine independent feeding observations with rigorous assessment of temporal variation in resource availability when modelling feeding selectivity.
[Mh] Termos MeSH primário: Cercopithecidae/fisiologia
Dieta
Comportamento Alimentar
Frutas
Hylobates/fisiologia
Simpatria/fisiologia
[Mh] Termos MeSH secundário: Animais
Abastecimento de Alimentos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0173369


  4 / 1056 MEDLINE  
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[PMID]:27804125
[Au] Autor:Dunham NT; Kane EE; McGraw WS
[Ad] Endereço:Department of Anthropology, The Ohio State University, 4034 Smith Laboratory, 174 West 18th Ave, Columbus, Ohio, 43210-1106.
[Ti] Título:Humeral correlates of forelimb elevation in four West African cercopithecid monkeys.
[So] Source:Am J Phys Anthropol;162(2):337-349, 2017 Feb.
[Is] ISSN:1096-8644
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: We previously found that differing degrees of forelimb flexion, elevation, and abduction during nonlocomotor foraging activities covaried with scapular morphology among four sympatric cercopithecids. The purpose of this study is to investigate whether features of the proximal humerus are similarly related to forelimb elevation during foraging. METHODS: Our sample consists of humeri (n = 42) of adult Cercocebus atys, Cercopithecus diana, Colobus polykomos, and Piliocolobus badius collected from Côte d'Ivoire's Taï National Park. Features of the proximal humerus known to correspond with varying degrees of forelimb mobility were examined using a combination of 2-dimensional caliper-based indices and 3-dimensional analyses. RESULTS: Some features of the proximal humerus are consistent with the varying frequencies of forelimb elevation during foraging. For instance, the red colobus (P. badius) has a variety of features consistent with more pronounced shoulder mobility and forelimb flexibility including a wider, more distally projecting deltoid plane, greater tuberosity positioned below the humeral head articular surface, and larger intertuberosity angle. CONCLUSIONS: The colobines, particularly P. badius, display a number of humeral and scapular features indicative of greater arm flexion, elevation, and abduction compared to the two cercopithecines. We conclude that idiosyncrasies in forelimb use during foraging are reflected in functionally relevant features of the cercopithecid proximal humerus, highlighting that postural behavior, in additional to locomotor behavior, can exert selective pressures on primate skeletal form. This result should provide for more informed reconstructions of the full positional repertoires in fossil taxa.
[Mh] Termos MeSH primário: Cercopithecidae/anatomia & histologia
Cercopithecidae/fisiologia
Úmero/anatomia & histologia
Úmero/fisiologia
[Mh] Termos MeSH secundário: Animais
Antropologia Física
Costa do Marfim
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161103
[St] Status:MEDLINE
[do] DOI:10.1002/ajpa.23123


  5 / 1056 MEDLINE  
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[PMID]:27691958
[Au] Autor:Flanders JA; Buoscio DA; Jacobs BA; Gamble KC
[Ti] Título:RETROSPECTIVE ANALYSIS OF ADULT-ONSET CARDIAC DISEASE IN FRANÇOIS' LANGURS (TRACHYPITHECUS FRANCOISI) HOUSED IN U.S. ZOOS.
[So] Source:J Zoo Wildl Med;47(3):717-730, 2016 Sep.
[Is] ISSN:1042-7260
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cardiac disease is a common condition in captive primates, and multiple cases in François' langurs ( Trachypithecus francoisi ) were noted on review of the Species Survival Plan studbook. To determine the prevalence of cardiac disease in this species, surveys were distributed to current and previous holding institutions (n = 23) for the U.S. studbook population (n = 216). After exclusion of stillbirths (n = 48), animals less than 1 yr of age (n = 8), and animals housed internationally (n = 2), a study group (n = 158) was identified for this analysis. Robust data was received for 98.7% (n = 156) of the study group and antemortem and postmortem cardiac abnormalities were reported for 25.3% (n = 40) of these animals. Eight animals were reported as medically managed for clinical cardiac disease, and three of these were alive at the time of survey. Six of 11 animals with radiographic cardiac silhouette enlargement antemortem were noted with cardiomegaly on postmortem examination. Of 102 deceased animals in the study group, four were identified with dilated cardiomyopathy, and varying degrees of myocardial fibrosis was observed in 18 animals. Langurs with cardiac fibrosis were found to be significantly older than langurs without cardiac fibrosis (P = 0.003) and more commonly were male (P = 0.036). Screening tests for cardiac disease, such as thoracic radiographs and echocardiography, are recommended to diagnose affected animals earlier, to monitor progression of disease, and to guide treatment, although they should be interpreted with caution because of apparent insensitivity when compared with pathologic results.
[Mh] Termos MeSH primário: Animais de Zoológico
Cercopithecidae
Cardiopatias/veterinária
Doenças dos Macacos/epidemiologia
[Mh] Termos MeSH secundário: Animais
Feminino
Cardiopatias/diagnóstico
Cardiopatias/epidemiologia
Cardiopatias/terapia
Masculino
Doenças dos Macacos/diagnóstico
Doenças dos Macacos/terapia
Estudos Retrospectivos
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170107
[Lr] Data última revisão:
170107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161004
[St] Status:MEDLINE


  6 / 1056 MEDLINE  
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[PMID]:27564405
[Au] Autor:Ram MS; Kittur SM; Biswas J; Nag S; Shil J; Umapathy G
[Ad] Endereço:Laboratory for the Conservation of Endangered Species, CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500007, India.
[Ti] Título:Genetic Diversity and Structure among Isolated Populations of the Endangered Gees Golden Langur in Assam, India.
[So] Source:PLoS One;11(8):e0161866, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Gee's golden langur (Trachypithecus geei) is an endangered colobine primate, endemic to the semi-evergreen and mixed-deciduous forests of Indo-Bhutan border. During the last few decades, extensive fragmentation has caused severe population decline and local extinction of golden langur from several fragments. However, no studies are available on the impact of habitat fragmentation and the genetic diversity of golden langur in the fragmented habitats. The present study aimed to estimate the genetic diversity in the Indian population of golden langur. We sequenced and analyzed around 500 bases of the mitochondrial DNA (mtDNA) hypervariable region-I from 59 fecal samples of wild langur collected from nine forest fragments. Overall, genetic diversity was high (h = 0.934, π = 0.0244) and comparable with other colobines. Populations in smaller fragments showed lower nucleotide diversity compared to the larger forest fragments. The median-joining network of haplotypes revealed a genetic structure that corresponded with the geographical distribution. The Aie and Champabati Rivers were found to be a barrier to gene flow between golden langur populations. In addition, it also established that T. geei is monophyletic but revealed possible hybridization with capped langur, T. pileatus, in the wild. It is hoped that these findings would result in a more scientific approach towards managing the fragmented populations of this enigmatic species.
[Mh] Termos MeSH primário: Cercopithecidae/genética
Variação Genética/genética
[Mh] Termos MeSH secundário: Animais
Cercopithecidae/classificação
Conservação dos Recursos Naturais
DNA Mitocondrial/genética
Ecossistema
Espécies em Perigo de Extinção
Haplótipos/genética
Índia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Mitochondrial)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160827
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0161866


  7 / 1056 MEDLINE  
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[PMID]:27393659
[Au] Autor:Fish I; Boissinot S
[Ad] Endereço:Biology Department, Queens College, The City University of New York, 65-30 Kissena Boulevard, Flushing, NY 11367, USA; Graduate Center, Sub-program in Molecular, Cellular and Developmental Biology, The City University of New York, 365(th) avenue, New York, NY 10016, USA. Electronic address: bloodcell@gmail.com.
[Ti] Título:Functional evolution of the OAS1 viral sensor: Insights from old world primates.
[So] Source:Infect Genet Evol;44:341-50, 2016 Oct.
[Is] ISSN:1567-7257
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Infections with viral pathogens impose considerable selective pressure on host defensive genes. Those genes at the forefront, responsible for identifying and binding exogenous molecular viral components, will carry the hallmarks of this struggle. Oligoadenylate synthetase (OAS) enzymes play a major role in the innate defense against a large number of viruses by acting as sensors of viral infections. Following their up-regulation by the interferon pathway, OASs bind viral dsRNA and then signal ribonuclease L (RNase L) to degrade RNA, shutting down viral and host protein synthesis. We have investigated the evolution of OAS1 in twenty-two Old World monkey species. We identified a total of 35 codons with the earmarks of positive selection and we performed a comprehensive analysis of their functional significance using in silico modeling of the OAS1 protein. Subdividing OAS1 into functional domains revealed intense purifying selection in the active domain but significant positive directional selection in the RNA-binding domain (RBD), the region where OAS1 binds viral dsRNA. The modeling analysis revealed a concentration of rapidly evolving residues in one region of the RBD suggestive of the sub-functionalization of different regions of the RBD. This analysis also identified several positively selected residues circumscribing the entry to the active site suggesting adaptive evasion of viral antagonism and/or selection for production of oligoadenylate of different length.
[Mh] Termos MeSH primário: 2´,5´-Oligoadenilato Sintetase/genética
2´,5´-Oligoadenilato Sintetase/metabolismo
Evolução Biológica
Interações Hospedeiro-Patógeno
Viroses/genética
Viroses/metabolismo
[Mh] Termos MeSH secundário: 2',5'-Oligoadenilato Sintetase/química
Sequência de Aminoácidos
Animais
Sítios de Ligação
Domínio Catalítico
Cercopithecidae
Resistência à Doença/genética
Evolução Molecular
Variação Genética
Interações Hospedeiro-Patógeno/genética
Interações Hospedeiro-Patógeno/imunologia
Imunidade Inata
Modelos Moleculares
Filogenia
Conformação Proteica
RNA de Cadeia Dupla/metabolismo
Motivos de Ligação ao RNA
Seleção Genética
Análise de Sequência de DNA
Viroses/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Double-Stranded); EC 2.7.7.84 (2',5'-Oligoadenylate Synthetase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171001
[Lr] Data última revisão:
171001
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160710
[St] Status:MEDLINE


  8 / 1056 MEDLINE  
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[PMID]:27335406
[Au] Autor:Donahue CJ; Sotiropoulos SN; Jbabdi S; Hernandez-Fernandez M; Behrens TE; Dyrby TB; Coalson T; Kennedy H; Knoblauch K; Van Essen DC; Glasser MF
[Ad] Endereço:Department of Neuroscience, Washington University School of Medicine, St. Louis, Missouri 63110.
[Ti] Título:Using Diffusion Tractography to Predict Cortical Connection Strength and Distance: A Quantitative Comparison with Tracers in the Monkey.
[So] Source:J Neurosci;36(25):6758-70, 2016 Jun 22.
[Is] ISSN:1529-2401
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:UNLABELLED: Tractography based on diffusion MRI offers the promise of characterizing many aspects of long-distance connectivity in the brain, but requires quantitative validation to assess its strengths and limitations. Here, we evaluate tractography's ability to estimate the presence and strength of connections between areas of macaque neocortex by comparing its results with published data from retrograde tracer injections. Probabilistic tractography was performed on high-quality postmortem diffusion imaging scans from two Old World monkey brains. Tractography connection weights were estimated using a fractional scaling method based on normalized streamline density. We found a correlation between log-transformed tractography and tracer connection weights of r = 0.59, twice that reported in a recent study on the macaque. Using a novel method to estimate interareal connection lengths from tractography streamlines, we regressed out the distance dependence of connection strength and found that the correlation between tractography and tracers remains positive, albeit substantially reduced. Altogether, these observations provide a valuable, data-driven perspective on both the strengths and limitations of tractography for analyzing interareal corticocortical connectivity in nonhuman primates and a framework for assessing future tractography methodological refinements objectively. SIGNIFICANCE STATEMENT: Tractography based on diffusion MRI has great potential for a variety of applications, including estimation of comprehensive maps of neural connections in the brain ("connectomes"). Here, we describe methods to assess quantitatively tractography's performance in detecting interareal cortical connections and estimating connection strength by comparing it against published results using neuroanatomical tracers. We found the correlation of tractography's estimated connection strengths versus tracer to be twice that of a previous study. Using a novel method for calculating interareal cortical distances, we show that tractography-based estimates of connection strength have useful predictive power beyond just interareal separation. By freely sharing these methods and datasets, we provide a valuable resource for future studies in cortical connectomics.
[Mh] Termos MeSH primário: Córtex Cerebral/diagnóstico por imagem
Imagem de Tensor de Difusão
Fibras Nervosas/fisiologia
Rede Nervosa/diagnóstico por imagem
[Mh] Termos MeSH secundário: Animais
Mapeamento Encefálico
Cercopithecidae
Conectoma
Lateralidade Funcional
Processamento de Imagem Assistida por Computador
Modelos Neurológicos
Rede Nervosa/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160624
[St] Status:MEDLINE
[do] DOI:10.1523/JNEUROSCI.0493-16.2016


  9 / 1056 MEDLINE  
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[PMID]:27234173
[Au] Autor:Sharma N; Huffman MA; Gupta S; Nautiyal H; Mendonça R; Morino L; Sinha A
[Ad] Endereço:School of Natural Sciences and Engineering, National Institute of Advanced Studies, Indian Institute of Science Campus, Bangalore 560012, Karnataka, India; Nature Conservation Foundation, 2076/5, IV Cross, Gokulam Park, Mysore 570002, Karnataka, India; Department of Environmental Biology and Wildlif
[Ti] Título:Watering holes: The use of arboreal sources of drinking water by Old World monkeys and apes.
[So] Source:Behav Processes;129:18-26, 2016 Aug.
[Is] ISSN:1872-8308
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Water is one of the most important components of an animal's diet, as it is essential for life. Primates, as do most animals, procure water directly from standing or free-flowing sources such as pools, ponds and rivers, or indirectly by the ingestion of certain plant parts. The latter is frequently described as the main source of water for predominantly arboreal species. However, in addition to these, many species are known to drink water accumulated in tree-holes. This has been commonly observed in several arboreal New World primate species, but rarely reported systematically from Old World primates. Here, we report observations of this behaviour from eight great ape and Old World monkey species, namely chimpanzee, orangutan, siamang, western hoolock gibbon, northern pig-tailed macaque, bonnet macaque, rhesus macaque and the central Himalayan langur. We hypothesise three possible reasons why these primates drink water from tree-holes: (1) coping with seasonal or habitat-specific water shortages, (2) predator/human conflict avoidance, and (3) potential medicinal benefits. We also suggest some alternative hypotheses that should be tested in future studies. This behaviour is likely to be more prevalent than currently thought, and may have significant, previously unknown, influences on primate survival and health, warranting further detailed studies.
[Mh] Termos MeSH primário: Cercopithecidae
Comportamento de Ingestão de Líquido
Água Potável
Hominidae
Árvores
[Mh] Termos MeSH secundário: Animais
Feminino
Masculino
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drinking Water)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170306
[Lr] Data última revisão:
170306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160529
[St] Status:MEDLINE


  10 / 1056 MEDLINE  
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[PMID]:27189538
[Au] Autor:McLaughlin RN; Gable JT; Wittkopp CJ; Emerman M; Malik HS
[Ad] Endereço:Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA hsmalik@fhcrc.org.
[Ti] Título:Conservation and Innovation of APOBEC3A Restriction Functions during Primate Evolution.
[So] Source:Mol Biol Evol;33(8):1889-901, 2016 Aug.
[Is] ISSN:1537-1719
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:LINE-1 (long interspersed element-1) retroelements are the only active autonomous endogenous retroelements in human genomes. Their retrotransposition activity has created close to 50% of the current human genome. Due to the apparent costs of this proliferation, host genomes have evolved multiple mechanisms to curb LINE-1 retrotransposition. Here, we investigate the evolution and function of the LINE-1 restriction factor APOBEC3A, a member of the APOBEC3 cytidine deaminase gene family. We find that APOBEC3A genes have evolved rapidly under diversifying selection in primates, suggesting changes in APOBEC3A have been recurrently selected in a host-pathogen "arms race." Nonetheless, in contrast to previous reports, we find that the LINE-1 restriction activity of APOBEC3A proteins has been strictly conserved throughout simian primate evolution in spite of its pervasive diversifying selection. Based on these results, we conclude that LINE-1s have not driven the rapid evolution of APOBEC3A in primates. In contrast to this conserved LINE-1 restriction, we find that a subset of primate APOBEC3A genes have enhanced antiviral restriction. We trace this gain of antiviral restriction in APOBEC3A to the common ancestor of a subset of Old World monkeys. Thus, APOBEC3A has not only maintained its LINE-1 restriction ability, but also evolved a gain of antiviral specificity against other pathogens. Our findings suggest that while APOBEC3A has evolved to restrict additional pathogens, only those adaptive amino acid changes that leave LINE-1 restriction unperturbed have been tolerated.
[Mh] Termos MeSH primário: Citidina Desaminase/genética
Elementos Nucleotídeos Longos e Dispersos
Proteínas/genética
[Mh] Termos MeSH secundário: Animais
Evolução Biológica
Cercopithecidae
Citidina Desaminase/metabolismo
Evolução Molecular
Genoma Humano
Seres Humanos
Primatas
Proteínas/metabolismo
Retroelementos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Proteins); 0 (Retroelements); EC 3.5.4.5 (APOBEC3A protein, human); EC 3.5.4.5 (Cytidine Deaminase)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170801
[Lr] Data última revisão:
170801
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160519
[St] Status:MEDLINE
[do] DOI:10.1093/molbev/msw070



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