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[PMID]:27687524
[Au] Autor:Muroyama Y
[Ad] Endereço:Primate Research Institute, Kyoto University, 41-2, Inuyama, Aichi, 484-8506, Japan. muroyama@toyo.jp.
[Ti] Título:Variations in within-group inter-individual distances between birth- and non-birth seasons in wild female patas monkeys.
[So] Source:Primates;58(1):115-119, 2017 Jan.
[Is] ISSN:1610-7365
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Individual spatial positioning plays an important role in mediating the costs and benefits of group living, and thus shapes different aspects of animal social systems including group structure and cohesiveness. I aimed to quantify variation in individual spacing behavior and its correlates in a group of wild patas monkeys (Erythrocebus patas) living in north Cameroon. I collected data on inter-individual distances during group scans when following subject females. Individuals had longer inter-individual distances during the non-birth season than during the birth season. Dominance relationships had little effect on inter-individual distances between females during both the non-birth and birth seasons. The results suggest that group cohesion was higher during the birth season than the non-birth season. Thus I conclude that higher group cohesion during the birth season may reduce the predation risk of infants.
[Mh] Termos MeSH primário: Erythrocebus patas/fisiologia
Comportamento Social
[Mh] Termos MeSH secundário: Animais
Camarões
Feminino
Parto
Estações do Ano
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171014
[Lr] Data última revisão:
171014
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161001
[St] Status:MEDLINE
[do] DOI:10.1007/s10329-016-0578-3


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[PMID]:27452341
[Au] Autor:Liu Y; Shim Park E; Gibbons AT; Shide ED; Divi RL; Woodward RA; Poirier MC
[Ad] Endereço:Carcinogen-DNA Interactions Section, Laboratory of Cancer Biology and Genetics, CCR, National Cancer Institute, NIH, Bethesda, Madison.
[Ti] Título:Mitochondrial compromise in 3-year old patas monkeys exposed in utero to human-equivalent antiretroviral therapies.
[So] Source:Environ Mol Mutagen;57(7):526-34, 2016 Aug.
[Is] ISSN:1098-2280
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Antiretroviral (ARV) drug therapy, given during pregnancy for prevention of mother-to-child transmission of human immunodeficiency virus 1 (HIV-1), induces fetal mitochondrial dysfunction in some children. However, the persistence/reversibility of that dysfunction is unclear. Here we have followed Erythrocebus patas (patas) monkey offspring for up to 3 years of age (similar in development to a 15-year old human) after exposure of the dams to human-equivalent in utero ARV exposure protocols. Pregnant patas dams (3-5/exposure group) were given ARV drug combinations that included zidovudine (AZT)/lamivudine (3TC)/abacavir (ABC), or AZT/3TC/nevirapine (NVP), for the last 10 weeks (50%) of gestation. Infants kept for 1 and 3 years also received drug for the first 6 weeks of life. In offpsring at birth, 1 and 3 years of age mitochondrial morphology, examined by electron microscopy (EM), was compromised compared to the unexposed controls. Mitochondrial DNA (mtDNA), measured by hybrid capture chemiluminescence assay (HCCA) was depleted in hearts of patas exposed to AZT/3TC/NVP at all ages (P < 0.05), but not in those exposed to AZT/3TC/ABC at any age. Compared to unexposed controls, mitochondrial reserve capacity oxygen consumption rate (OCR by Seahorse) in cultured bone marrow mesenchymal fibroblasts from 3-year-old patas offspring was ∼50% reduced in AZT/3TC/ABC-exposed patas (P < 0.01), but not in AZT/3TC/NVP-exposed patas. Overall the data show that 3-year-old patas sustain persistent mitochondrial dysfunction as a result of perinatal ARV drug exposure. Environ. Mol. Mutagen. 57:526-534, 2016. © 2016 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Fármacos Anti-HIV/toxicidade
DNA Mitocondrial/análise
Mitocôndrias/efeitos dos fármacos
Efeitos Tardios da Exposição Pré-Natal/induzido quimicamente
[Mh] Termos MeSH secundário: Animais
Fármacos Anti-HIV/administração & dosagem
Células da Medula Óssea/efeitos dos fármacos
Células da Medula Óssea/metabolismo
Encéfalo/efeitos dos fármacos
Encéfalo/crescimento & desenvolvimento
Encéfalo/patologia
DNA Mitocondrial/genética
Didesoxinucleosídeos/administração & dosagem
Didesoxinucleosídeos/toxicidade
Quimioterapia Combinada
Erythrocebus patas
Feminino
Idade Gestacional
Coração/efeitos dos fármacos
Coração/crescimento & desenvolvimento
Lamivudina/administração & dosagem
Lamivudina/toxicidade
Mitocôndrias/genética
Mitocôndrias/ultraestrutura
Mitocôndrias Cardíacas/efeitos dos fármacos
Mitocôndrias Cardíacas/genética
Mitocôndrias Cardíacas/ultraestrutura
Consumo de Oxigênio/efeitos dos fármacos
Gravidez
Efeitos Tardios da Exposição Pré-Natal/genética
Efeitos Tardios da Exposição Pré-Natal/patologia
Zidovudina/administração & dosagem
Zidovudina/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-HIV Agents); 0 (DNA, Mitochondrial); 0 (Dideoxynucleosides); 2T8Q726O95 (Lamivudine); 4B9XT59T7S (Zidovudine); WR2TIP26VS (abacavir)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170801
[Lr] Data última revisão:
170801
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160726
[St] Status:MEDLINE
[do] DOI:10.1002/em.22033


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[PMID]:25635584
[Au] Autor:Poirier MC; Gibbons AT; Rugeles MT; Andre-Schmutz I; Blanche S
[Ad] Endereço:aCarcinogen-DNA Interactions Section, Laboratory of Cancer Biology and Genetics, CCR, National Cancer Institute, NIH, Bethesda, Maryland, USA bGrupo Imunovirologia, School of Medicine Universidad de Antioquia, Medellin, Colombia cInstitut National de la Sante et de la Recherche Medicale, Universite Paris Descartes, Sorbonne Paris Cite, Paris, France dUnite d'Immunologie-Hematologie Pediatrique, Hopital Necker-Enfants Malades, Paris, France.
[Ti] Título:Fetal consequences of maternal antiretroviral nucleoside reverse transcriptase inhibitor use in human and nonhuman primate pregnancy.
[So] Source:Curr Opin Pediatr;27(2):233-9, 2015 Apr.
[Is] ISSN:1531-698X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF REVIEW: Here we present fetal genotoxicity and mitochondrial toxicity, induced by nucleoside reverse transcriptase inhibitors (NRTIs), in HIV-1-infected pregnant women treated to prevent mother-to-child HIV-1 transmission, and in virus-free pregnant patas monkeys. RECENT FINDINGS: In the offspring of pregnant patas monkeys given human-equivalent NRTI protocols, aneuploidy was found in cultured bone marrow cells taken at birth, 1, and 3 years of age. In some newborn human infants, the offspring of HIV-1-infected mothers given zidovudine (AZT) therapy, aneuploidy, mitochondrial DNA (mtDNA) depletion, morphologically damaged mitochondria, and reduction in cardiac left ventricular muscle were observed. NRTI-exposed human and patas umbilical cords had similar levels of mtDNA depletion and mitochondrial morphological damage. NRTI-exposed patas offspring showed a compensatory increase in heart mtDNA, and a 50% loss of brain mtDNA at 1 year of age. Mitochondrial morphological damage and mtDNA loss were persistent in blood cells of NRTI-exposed infants up to 2 years of age, and in heart and brain from NRTI-exposed patas up to 3 years of age (human equivalent of 15 years). SUMMARY: Whereas use of NRTIs in human pregnancy protects many thousands of children worldwide, some HIV-1-uninfected infants born to HIV-1-infected mothers receiving antiretroviral drug therapy sustain toxicities that may have adverse consequences later in life.
[Mh] Termos MeSH primário: DNA Mitocondrial/efeitos dos fármacos
Infecções por HIV/tratamento farmacológico
Transmissão Vertical de Doença Infecciosa/prevenção & controle
Complicações Infecciosas na Gravidez/tratamento farmacológico
Inibidores da Transcriptase Reversa/efeitos adversos
Zidovudina/efeitos adversos
[Mh] Termos MeSH secundário: Aneuploidia
Animais
Animais Recém-Nascidos
DNA Mitocondrial/fisiologia
Modelos Animais de Doenças
Erythrocebus patas
Feminino
Infecções por HIV/prevenção & controle
Seres Humanos
Lactente
Recém-Nascido
Troca Materno-Fetal
Gravidez
Inibidores da Transcriptase Reversa/farmacologia
Inibidores da Transcriptase Reversa/toxicidade
Zidovudina/farmacologia
Zidovudina/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., INTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (DNA, Mitochondrial); 0 (Reverse Transcriptase Inhibitors); 4B9XT59T7S (Zidovudine)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:161025
[Lr] Data última revisão:
161025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150131
[St] Status:MEDLINE
[do] DOI:10.1097/MOP.0000000000000193


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[PMID]:25304980
[Au] Autor:Vicens A; Gómez Montoto L; Couso-Ferrer F; Sutton KA; Roldan ER
[Ad] Endereço:Reproductive Ecology and Biology Group, Museo Nacional de Ciencias Naturales (CSIC), 28006, Madrid, Spain.
[Ti] Título:Sexual selection and the adaptive evolution of PKDREJ protein in primates and rodents.
[So] Source:Mol Hum Reprod;21(2):146-56, 2015 Feb.
[Is] ISSN:1460-2407
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PKDREJ is a testis-specific protein thought to be located on the sperm surface. Functional studies in the mouse revealed that loss of PKDREJ has effects on sperm transport and the ability to undergo an induced acrosome reaction. Thus, PKDREJ has been considered a potential target of post-copulatory sexual selection in the form of sperm competition. Proteins involved in reproductive processes often show accelerated evolution. In many cases, this rapid divergence is promoted by positive selection which may be driven, at least in part, by post-copulatory sexual selection. We analysed the evolution of the PKDREJ protein in primates and rodents and assessed whether PKDREJ divergence is associated with testes mass relative to body mass, which is a reliable proxy of sperm competition levels. Evidence of an association between the evolutionary rate of the PKDREJ gene and testes mass relative to body mass was not found in primates. Among rodents, evidence of positive selection was detected in the Pkdrej gene in the family Cricetidae but not in Muridae. We then assessed whether Pkdrej divergence is associated with episodes of sperm competition in these families. We detected a positive significant correlation between the evolutionary rates of Pkdrej and testes mass relative to body mass in cricetids. These findings constitute the first evidence of post-copulatory sexual selection influencing the evolution of a protein that participates in the mechanisms regulating sperm transport and the acrosome reaction, strongly suggesting that positive selection may act on these fertilization steps, leading to advantages in situations of sperm competition.
[Mh] Termos MeSH primário: Primatas/fisiologia
Roedores/fisiologia
[Mh] Termos MeSH secundário: Animais
Evolução Biológica
Erythrocebus patas
Gorilla gorilla
Seres Humanos
Macaca mulatta
Macaca nemestrina
Masculino
Pan paniscus
Pan troglodytes
Pongo pygmaeus
Primatas/classificação
Primatas/genética
Roedores/classificação
Roedores/genética
Espermatozoides/metabolismo
Espermatozoides/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1510
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141012
[St] Status:MEDLINE
[do] DOI:10.1093/molehr/gau095


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[PMID]:24967517
[Au] Autor:Allen WL; Stevens M; Higham JP
[Ad] Endereço:1] Department of Anthropology, New York University, New York, New York 10003, USA [2].
[Ti] Título:Character displacement of Cercopithecini primate visual signals.
[So] Source:Nat Commun;5:4266, 2014 Jun 26.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Animal visual signals have the potential to act as an isolating barrier to prevent interbreeding of populations through a role in species recognition. Within communities of competing species, species recognition signals are predicted to undergo character displacement, becoming more visually distinctive from each other; however, this pattern has rarely been identified. Using computational face recognition algorithms to model primate face processing, we demonstrate that the face patterns of guenons (tribe: Cercopithecini) have evolved under selection to become more visually distinctive from those of other guenon species with whom they are sympatric. The relationship between the appearances of sympatric species suggests that distinguishing conspecifics from other guenon species has been a major driver of diversification in guenon face appearance. Visual signals that have undergone character displacement may have had an important role in the tribe's radiation, keeping populations that became geographically separated reproductively isolated on secondary contact.
[Mh] Termos MeSH primário: Evolução Biológica
Cercopithecidae
Face
Reconhecimento Visual de Modelos
Seleção Genética
[Mh] Termos MeSH secundário: Animais
Identificação Biométrica
Cercopithecinae
Cercopithecus
Simulação por Computador
Erythrocebus patas
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1507
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140627
[St] Status:MEDLINE
[do] DOI:10.1038/ncomms5266


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[PMID]:24501327
[Au] Autor:Hernandez-Ramon EE; Sandoval NA; John K; Cline JM; Wood CE; Woodward RA; Poirier MC
[Ad] Endereço:Carcinogen-DNA Interactions Section, LCBG, CCR, National Cancer Institute, NIH, Building 37, Room 4032, NIH 37 Convent Drive, MSC-4255, Bethesda, MD 20892, USA.
[Ti] Título:Tamoxifen-DNA adduct formation in monkey and human reproductive organs.
[So] Source:Carcinogenesis;35(5):1172-6, 2014 May.
[Is] ISSN:1460-2180
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The estrogen analog tamoxifen (TAM), used for adjuvant therapy of breast cancer, induces endometrial and uterine tumors in breast cancer patients. Proliferation stimulus of the uterine endometrium is likely involved in tumor induction, but genotoxicity may also play a role. Formation of TAM-DNA adducts in human tissues has been reported but remains controversial. To address this issue, we examined TAM-DNA adducts in uteri from two species of monkeys, Erythrocebus patas (patas) and Macaca fascicularis (macaque), and in human endometrium and myometrium. Monkeys were given 3-4 months of chronic TAM dosing scaled to be equivalent to the daily human dose. In the uteri, livers and brains from the patas (n = 3), and endometrium from the macaques (n = 4), TAM-DNA adducts were measurable by TAM-DNA chemiluminescence immunoassay. Average TAM-DNA adduct values for the patas uteri (23 adducts/10(8) nucleotides) were similar to those found in endometrium of the macaques (19 adducts/10(8) nucleotides). Endometrium of macaques exposed to both TAM and low-dose estradiol (n = 5) averaged 34 adducts/10(8) nucleotides. To examine TAM-DNA persistence in the patas, females (n = 3) were exposed to TAM for 3 months and to no drug for an additional month, resulting in low or non-detectable TAM-DNA in livers and uteri. Human endometrial and myometrial samples from women receiving (n = 8) and not receiving (n = 8) TAM therapy were also evaluated. Women receiving TAM therapy averaged 10.3 TAM-DNA adducts/10(8) nucleotides, whereas unexposed women showed no detectable TAM-DNA. The data indicate that genotoxicity, in addition to estrogen agonist effects, may contribute to TAM-induced human endometrial cancer.
[Mh] Termos MeSH primário: Adutos de DNA/metabolismo
DNA/metabolismo
Tamoxifeno/metabolismo
Útero/metabolismo
[Mh] Termos MeSH secundário: Animais
DNA/química
Adutos de DNA/efeitos adversos
Adutos de DNA/química
Endométrio/metabolismo
Erythrocebus patas
Feminino
Seres Humanos
Miométrio/metabolismo
Tamoxifeno/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., INTRAMURAL
[Nm] Nome de substância:
0 (DNA Adducts); 094ZI81Y45 (Tamoxifen); 9007-49-2 (DNA)
[Em] Mês de entrada:1406
[Cu] Atualização por classe:161019
[Lr] Data última revisão:
161019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140207
[St] Status:MEDLINE
[do] DOI:10.1093/carcin/bgu029


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[PMID]:24129761
[Au] Autor:Herman EH; Knapton A; Liu Y; Lipshultz SE; Estis J; Todd J; Woodward RA; Cochran T; Zhang J; Poirier MC
[Ad] Endereço:Food and Drug Administration, Division of Drug Safety Research, Silver Spring, Maryland, USA eugene.herman@fda.hhs.gov.
[Ti] Título:The influence of age on serum concentrations of cardiac troponin I: results in rats, monkeys, and commercial sera.
[So] Source:Toxicol Pathol;42(5):888-96, 2014 Jul.
[Is] ISSN:1533-1601
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cardiac troponins serve as serum biomarkers of myocardial injury. The current study examined the influence of age on serum concentrations of cardiac troponin I (cTnI). An ultrasensitive immunoassay was used to monitor cTnI concentrations in Sprague-Dawley (SD) rats and Erythrocebus patas monkeys of different ages. The mean cTnI concentrations were highest in 10-day-old rats compared to 25-, 40-, and 80-day-old SD rats. Cardiomyocyte remodeling was apparent in hearts from 10-day-old SD rats as evident by hypercellularity, irregularly shaped nuclei, and moderate numbers of myocytes undergoing mitosis and apoptosis. The mean concentration of cTnI in 5 newborn monkeys was considerably higher than that of three 1-year-old monkeys. Evidence of cardiomyocyte remodeling was also observed in these newborn hearts (loss of myofibrils and cytoplasmic vacuolation). Commercial animal serum samples were also analyzed. The concentrations of cTnI detected in fetal equine and porcine serum were considerably higher than that found in adult equine and porcine serum samples Likewise, fetal bovine serum had higher cTnI concentrations (>2,400 pg/ml) than did adult caprine and laprine samples (2.5-2.7 pg/ml). The present study found age-related differences in cTnI concentrations, with higher levels occurring at younger ages. This effect was consistent across several animal species.
[Mh] Termos MeSH primário: Fatores Etários
Biomarcadores/sangue
Troponina I/sangue
[Mh] Termos MeSH secundário: Animais
Bovinos
Erythrocebus patas
Feminino
Traumatismos Cardíacos/sangue
Cavalos
Imunoensaio
Masculino
Miocárdio/metabolismo
Miofibrilas/metabolismo
Ratos
Ratos Sprague-Dawley
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Troponin I)
[Em] Mês de entrada:1511
[Cu] Atualização por classe:150408
[Lr] Data última revisão:
150408
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131017
[St] Status:MEDLINE
[do] DOI:10.1177/0192623313505154


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[PMID]:23559463
[Au] Autor:Olivero OA; Torres LR; Gorjifard S; Momot D; Marrogi E; Divi RL; Liu Y; Woodward RA; Sowers MJ; Poirier MC
[Ad] Endereço:Carcinogen-DNA Interactions Section, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD 20892-4255, USA.
[Ti] Título:Perinatal exposure of patas monkeys to antiretroviral nucleoside reverse-transcriptase inhibitors induces genotoxicity persistent for up to 3 years of age.
[So] Source:J Infect Dis;208(2):244-8, 2013 Jul 15.
[Is] ISSN:1537-6613
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Erythrocebus patas (patas) monkeys were used to model antiretroviral (ARV) drug in human immunodeficiency virus type 1-infected pregnant women. METHODS: Pregnant patas dams were given human-equivalent doses of ARVs daily during 50% of gestation. Mesenchymal cells, cultured from bone marrow of patas offspring obtained at birth and at 1 and 3 years of age, were examined for genotoxicity, including centrosomal amplification, micronuclei, and micronuclei containing whole chromosomes. RESULTS: Compared with controls, statistically significant increases (P < .05) in centrosomal amplification, micronuclei, and micronuclei containing whole chromosomes were found in mesenchymal cells from most groups of offspring at the 3 time points. CONCLUSIONS: Transplacental nucleoside reverse-transcriptase inhibitor exposures induced fetal genotoxicity that was persistent for 3 years.
[Mh] Termos MeSH primário: Fármacos Anti-HIV/efeitos adversos
Erythrocebus patas/genética
Erythrocebus patas/virologia
HIV-1
Mesoderma/efeitos dos fármacos
Efeitos Tardios da Exposição Pré-Natal
Inibidores da Transcriptase Reversa/efeitos adversos
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Feminino
Seres Humanos
Células Mesenquimais Estromais/virologia
Mesoderma/citologia
Nucleosídeos/genética
Gravidez
Complicações Infecciosas na Gravidez/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., INTRAMURAL
[Nm] Nome de substância:
0 (Anti-HIV Agents); 0 (Nucleosides); 0 (Reverse Transcriptase Inhibitors)
[Em] Mês de entrada:1311
[Cu] Atualização por classe:161019
[Lr] Data última revisão:
161019
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:130406
[St] Status:MEDLINE
[do] DOI:10.1093/infdis/jit146


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[PMID]:23280312
[Au] Autor:Isbell LA; Rothman JM; Young PJ; Rudolph K
[Ad] Endereço:Department of Anthropology, University of California, Davis, CA 95616, USA. laisbell@ucdavis.edu
[Ti] Título:Nutritional benefits of Crematogaster mimosae ants and Acacia drepanolobium gum for patas monkeys and vervets in Laikipia, Kenya.
[So] Source:Am J Phys Anthropol;150(2):286-300, 2013 Feb.
[Is] ISSN:1096-8644
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Patas monkeys (Erythrocebus patas) are midsized primates that feed extensively on the gum of Acacia drepanolobium and the ants are housed in swollen thorns of this Acacia. Their diet resembles that expected more of smaller bodied primates. Patas monkeys are also more like smaller bodied primates in reproducing at high rates. We sought to better understand the convergence of patas monkeys with smaller bodied primates by comparing their feeding behavior on ants and gum with that of closely related, sympatric vervets (Chlorocebus pygerythrus), and analyzing the nutrient content of the gum of A. drepanolobium and of Crematogaster mimosae, the most common ant species eaten by patas monkeys in Laikipia, Kenya. All occurrences of feeding and moving during focal animal sampling revealed that 1) patas monkeys seek A. drepanolobium gum but vervets avoid it; 2) both species open swollen thorns most often in the morning when antsare less active; 3) patas monkeys continually feed onswollen thorns and gum while moving quickly throughout the day, whereas vervets reduce their consumption of these items and their travel rate at mid-day, and; 4) vervets eat young swollen thorns at a higher rate than patas monkeys. Patas monkeys are able to spend little time acquiring substantial amounts of energy, protein, and minerals from A. drepanolobium gum and C. mimosae ants each day. These findings, when coupled with evidence of causes of infant and adult female mortality, suggest that reproductive success of female patas monkeys is more immediately affected by illness, disease, interactions between adults and infants, and access to water than by food.
[Mh] Termos MeSH primário: Formigas/química
Cercopithecus aethiops/fisiologia
Erythrocebus patas/fisiologia
Comportamento Alimentar/fisiologia
Goma Arábica/química
Valor Nutritivo
[Mh] Termos MeSH secundário: Animais
Antropologia Física
Feminino
Quênia
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
9000-01-5 (Gum Arabic)
[Em] Mês de entrada:1305
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130103
[St] Status:MEDLINE
[do] DOI:10.1002/ajpa.22205


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[PMID]:23065699
[Au] Autor:Kreizinger Z; Makrai L; Helyes G; Magyar T; Erdélyi K; Gyuranecz M
[Ad] Endereço:Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, Hungária körút 21, H-1143 Budapest, Hungary.
[Ti] Título:Antimicrobial susceptibility of Francisella tularensis subsp. holarctica strains from Hungary, Central Europe.
[So] Source:J Antimicrob Chemother;68(2):370-3, 2013 Feb.
[Is] ISSN:1460-2091
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Determining the in vitro susceptibility to 11 antibiotics of Francisella tularensis subsp. holarctica strains belonging to the phylogenetic group B.13, from different areas of Hungary. METHODS: Twenty-nine F. tularensis strains isolated between 2003 and 2010 from free-ranging European brown hares (Lepus europaeus) and a captive patas monkey (Erythrocebus patas) were collected from different parts of Hungary and examined for antibiotic susceptibility with commercially available MIC test strips on modified Francis agar plates; values were interpreted according to CLSI breakpoints. RESULTS: The strains were susceptible to aminoglycosides (MIC(90) values: gentamicin, 0.75 mg/L; and streptomycin, 6.0 mg/L), tetracyclines (MIC(90) values: tetracycline, 0.5 mg/L; and doxycycline, 1.0 mg/L), quinolones (MIC(90) values: ciprofloxacin, 0.047 mg/L; and levofloxacin, 0.023 mg/L) and chloramphenicol (MIC(90) value: 1.5 mg/L), i.e. antibiotics commonly used in therapy. Tigecycline (MIC(90) value: 0.19 mg/L) and rifampicin (MIC(90) value: 1.0 mg/L) were also active against F. tularensis strains, while resistance to erythromycin (MIC(90) value: >256 mg/L) and linezolid (MIC(90) value: 32 mg/L) was observed in all strains. CONCLUSIONS: Based on the results, quinolones are recommended as first choice therapy for F. tularensis infection. The in vitro susceptibility of the strains to tigecycline may encourage the application of this antibiotic as well. The similar antibiotic susceptibilities of the Hungarian strains belonging to different subclades of phylogenetic group B.13 indicates that strains from other Central and Eastern European countries belonging to this group might also have the same susceptibility profile.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Erythrocebus patas/microbiologia
Francisella tularensis/efeitos dos fármacos
Lebres/microbiologia
[Mh] Termos MeSH secundário: Animais
Francisella tularensis/classificação
Francisella tularensis/genética
Francisella tularensis/isolamento & purificação
Genótipo
Hungria
Testes de Sensibilidade Microbiana
Tipagem Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1306
[Cu] Atualização por classe:130114
[Lr] Data última revisão:
130114
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121016
[St] Status:MEDLINE
[do] DOI:10.1093/jac/dks399



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