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  1 / 10824 MEDLINE  
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[PMID]:27778641
[Au] Autor:Joshi NR; Miyadahira EH; Afshar Y; Jeong JW; Young SL; Lessey BA; Serafini PC; Fazleabas AT
[Ad] Endereço:Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, Grand Rapids, Michigan 49503.
[Ti] Título:Progesterone Resistance in Endometriosis Is Modulated by the Altered Expression of MicroRNA-29c and FKBP4.
[So] Source:J Clin Endocrinol Metab;102(1):141-149, 2017 Jan 01.
[Is] ISSN:1945-7197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Context: Endometriosis results in aberrant gene expression in the eutopic endometrium (EuE) and subsequent progesterone resistance. MicroRNA (miR) microarray data in a baboon model of endometriosis showed an increased expression of miR-29c. Objectives: To explore the role of miR-29c in progesterone resistance in a subset of women with endometriosis. Design: MiR-29c expression was analyzed in the endometrium of baboons and women with or without endometriosis. The role in progesterone resistance and decidualization was analyzed by transfecting human uterine fibroblast cells with miR-29c. Patients: Subjects diagnosed with deep infiltrative endometriosis (DIE) by transvaginal ultrasound with bowel preparation underwent surgical excision of endometriosis. Eutopic secretory endometrium was collected pre- and postoperatively. Women with normal EuE and without DIE served as controls. Results: Quantitative reverse transcription polymerase chain reaction demonstrated that miR-29c expression increased, while the transcript levels of its target, FK506-binding protein 4 (FKBP4), decreased in the EuE of baboons following the induction of endometriosis. FKBP4 messenger RNA and decidual markers were statistically significantly decreased in decidualized human uterine fibroblast cells transfected with a miR-29c mimic compared with controls. Human data corroborated our baboon data and demonstrated higher expression of miR-29c in endometriosis EuE compared with normal EuE. MiR-29c was significantly decreased in endometriosis EuE postoperatively compared with preoperative tissues, and FKBP4 showed an inverse trend following radical laparoscopic resection surgery. Conclusions: We demonstrate that miR-29c expression is increased in EuE of baboons and women with endometriosis, which might contribute to a compromised progesterone response by diminishing the levels of FKBP4. Resection of DIE is likely to reverse the progesterone resistance associated with endometriosis in women.
[Mh] Termos MeSH primário: Biomarcadores/análise
Endometriose/genética
Endométrio/anormalidades
MicroRNAs/genética
Progesterona/farmacologia
Proteínas de Ligação a Tacrolimo/metabolismo
Doenças Uterinas/genética
[Mh] Termos MeSH secundário: Animais
Estudos de Casos e Controles
Modelos Animais de Doenças
Endometriose/tratamento farmacológico
Endometriose/patologia
Feminino
Seres Humanos
Papio
Prognóstico
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (MIRN29 microRNA, human); 0 (MicroRNAs); 4G7DS2Q64Y (Progesterone); EC 5.2.1.- (Tacrolimus Binding Proteins); EC 5.2.1.- (tacrolimus binding protein 4)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1210/jc.2016-2076


  2 / 10824 MEDLINE  
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[PMID]:28744878
[Au] Autor:King AM; Kirkwood TBL; Shanley DP
[Ad] Endereço:Institute for Cellular and Molecular Biosciences, Campus for Ageing and Vitality, Newcastle University, Newcastle Upon Tyne NE4 5PL, United Kingdom.
[Ti] Título:Explaining sex differences in lifespan in terms of optimal energy allocation in the baboon.
[So] Source:Evolution;71(10):2280-2297, 2017 10.
[Is] ISSN:1558-5646
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We provide a quantitative test of the hypothesis that sex role specialization may account for sex differences in lifespan in baboons if such specialization causes the dependency of fitness upon longevity, and consequently the optimal resolution to an energetic trade-off between somatic maintenance and other physiological functions, to differ between males and females. We present a model in which females provide all offspring care and males compete for access to reproductive females and in which the partitioning of available energy between the competing fitness-enhancing functions of growth, maintenance, and reproduction is modeled as a dynamic behavioral game, with the optimal decision for each individual depending upon his/her state and the behavior of other members of the population. Our model replicates the sexual dimorphism in body size and sex differences in longevity and reproductive scheduling seen in natural populations of baboons. We show that this outcome is generally robust to perturbations in model parameters, an important finding given that the same behavior is seen across multiple populations and species in the wild. This supports the idea that sex differences in longevity result from differences in the value of somatic maintenance relative to other fitness-enhancing functions in keeping with the disposable soma theory.
[Mh] Termos MeSH primário: Longevidade
Modelos Genéticos
Papio/genética
[Mh] Termos MeSH secundário: Animais
Tamanho Corporal/genética
Evolução Molecular
Feminino
Aptidão Genética
Masculino
Papio/crescimento & desenvolvimento
Papio/fisiologia
Reprodução
Fatores Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1111/evo.13316


  3 / 10824 MEDLINE  
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[PMID]:29239481
[Au] Autor:Torben W; Molehin AJ; Blair RV; Kenway C; Shiro F; Roslyn D; Chala B; Gutu D; Kebede MA; Ahmad G; Zhang W; Aye P; Mohan M; Lackner A; Siddiqui AA
[Ad] Endereço:Tulane National Primate Research Center, TNPRC, Comparative Pathology/Immunology, Tulane University Health Sciences Center, Covington, Louisiana.
[Ti] Título:The self-curing phenomenon of schistosome infection in rhesus macaques: insight from in vitro studies.
[So] Source:Ann N Y Acad Sci;1408(1):79-89, 2017 Nov.
[Is] ISSN:1749-6632
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A reduction in the burden of schistosomiasis is potentially achievable by integrating a schistosomiasis vaccine with current control measures. Here, we determine parasite-specific in vitro responses of B, T, and NK cells from naive uninfected rhesus macaques to Schistosoma mansoni (Sm) egg (SmEA) and worm antigen (SmWA) preparations isolated from infected baboons. Pronounced B cell responses to SmEA and NK cell responses to both SmEA and SmWA were observed. High levels of IL-2 and IL-21 responses against Sm antigens were observed in T and non-T cells of lymph nodes (LNs) and gut lamina propria-derived lymphocytes (LPLs). Data analysis showed multifunctionality of LN-derived CD4 , CD8 , and CD4 CD8 double positive T cells against either SmWA or SmWA+SmEA antigen preparations. Distinct SmEA-specific multifunctional responses were observed in gut LPLs, suggesting simultaneous responses against egg antigens. These data provide insight into the immune effectors involved in schistosome responses by rhesus macaques.
[Mh] Termos MeSH primário: Antígenos de Helmintos/imunologia
Doenças dos Macacos/imunologia
Schistosoma mansoni/imunologia
Esquistossomose mansoni/imunologia
Esquistossomose mansoni/veterinária
[Mh] Termos MeSH secundário: Animais
Linfócitos B/imunologia
Linfócitos T CD4-Positivos/imunologia
Linfócitos T CD8-Positivos/imunologia
Interleucina-2/imunologia
Interleucina-2/metabolismo
Interleucinas/imunologia
Interleucinas/metabolismo
Células Matadoras Naturais/imunologia
Linfonodos/imunologia
Macaca mulatta
Doenças dos Macacos/parasitologia
Papio
Remissão Espontânea
Schistosoma mansoni/fisiologia
Esquistossomose mansoni/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Helminth); 0 (Interleukin-2); 0 (Interleukins); 0 (interleukin-21)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171227
[Lr] Data última revisão:
171227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.1111/nyas.13565


  4 / 10824 MEDLINE  
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[PMID]:28886021
[Au] Autor:Strouhal M; Mikalová L; Havlícková P; Tenti P; Cejková D; Rychlík I; Bruisten S; Smajs D
[Ad] Endereço:Department of Biology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno, Czech Republic.
[Ti] Título:Complete genome sequences of two strains of Treponema pallidum subsp. pertenue from Ghana, Africa: Identical genome sequences in samples isolated more than 7 years apart.
[So] Source:PLoS Negl Trop Dis;11(9):e0005894, 2017 Sep.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Treponema pallidum subsp. pertenue (TPE) is the causative agent of yaws, a multi-stage disease, endemic in tropical regions of Africa, Asia, Oceania, and South America. To date, four TPE strains have been completely sequenced including three TPE strains of human origin (Samoa D, CDC-2, and Gauthier) and one TPE strain (Fribourg-Blanc) isolated from a baboon. All TPE strains are highly similar to T. pallidum subsp. pallidum (TPA) strains. The mutation rate in syphilis and related treponemes has not been experimentally determined yet. METHODOLOGY/PRINCIPAL FINDINGS: Complete genomes of two TPE strains, CDC 2575 and Ghana-051, that infected patients in Ghana and were isolated in 1980 and 1988, respectively, were sequenced and analyzed. Both strains had identical consensus genome nucleotide sequences raising the question whether TPE CDC 2575 and Ghana-051 represent two different strains. Several lines of evidence support the fact that both strains represent independent samples including regions showing intrastrain heterogeneity (13 and 5 intrastrain heterogeneous sites in TPE Ghana-051 and TPE CDC 2575, respectively). Four of these heterogeneous sites were found in both genomes but the frequency of alternative alleles differed. The identical consensus genome sequences were used to estimate the upper limit of the yaws treponeme evolution rate, which was 4.1 x 10-10 nucleotide changes per site per generation. CONCLUSIONS/SIGNIFICANCE: The estimated upper limit for the mutation rate of TPE was slightly lower than the mutation rate of E. coli, which was determined during a long-term experiment. Given the known diversity between TPA and TPE genomes and the assumption that both TPA and TPE have a similar mutation rate, the most recent common ancestor of syphilis and yaws treponemes appears to be more than ten thousand years old and likely even older.
[Mh] Termos MeSH primário: Genoma Bacteriano
Treponema pallidum/genética
Treponema pallidum/isolamento & purificação
Bouba/microbiologia
[Mh] Termos MeSH secundário: Animais
Ásia/epidemiologia
Mapeamento Cromossômico
Escherichia coli/genética
Gana/epidemiologia
Seres Humanos
Mutação
Papio/microbiologia
Análise de Sequência de DNA
América do Sul/epidemiologia
Fatores de Tempo
Treponema pallidum/classificação
Bouba/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005894


  5 / 10824 MEDLINE  
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[PMID]:28654263
[Au] Autor:Gobbi LC; Knust H; Körner M; Honer M; Czech C; Belli S; Muri D; Edelmann MR; Hartung T; Erbsmehl I; Grall-Ulsemer S; Koblet A; Rueher M; Steiner S; Ravert HT; Mathews WB; Holt DP; Kuwabara H; Valentine H; Dannals RF; Wong DF; Borroni E
[Ad] Endereço:Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. , CH-4070 Basel, Switzerland.
[Ti] Título:Identification of Three Novel Radiotracers for Imaging Aggregated Tau in Alzheimer's Disease with Positron Emission Tomography.
[So] Source:J Med Chem;60(17):7350-7370, 2017 Sep 14.
[Is] ISSN:1520-4804
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Aggregates of tau and beta amyloid (Aß) plaques constitute the histopathological hallmarks of Alzheimer's disease and are prominent targets for novel therapeutics as well as for biomarkers for diagnostic in vivo imaging. In recent years much attention has been devoted to the discovery and development of new PET tracers to image tau aggregates in the living human brain. Access to a selective PET tracer to image and quantify tau aggregates represents a unique tool to support the development of any novel therapeutic agent targeting pathological forms of tau. The objective of the study described herein was to identify such a novel radiotracer. As a result of this work, we discovered three novel PET tracers (2-(4-[ C]methoxyphenyl)imidazo[1,2-a]pyridin-7-amine 7 ([ C]RO6924963), N-[ C]methyl-2-(3-methylphenyl)imidazo[1,2-a]pyrimidin-7-amine 8 ([ C]RO6931643), and [ F]2-(6-fluoropyridin-3-yl)pyrrolo[2,3-b:4,5-c']dipyridine 9 ([ F]RO6958948)) with high affinity for tau neurofibrillary tangles, excellent selectivity against Aß plaques, and appropriate pharmacokinetic and metabolic properties in mice and non-human primates.
[Mh] Termos MeSH primário: Doença de Alzheimer/diagnóstico por imagem
Radioisótopos de Carbono/química
Radioisótopos de Flúor/química
Tomografia por Emissão de Pósitrons/métodos
Agregação Patológica de Proteínas/diagnóstico por imagem
Pirimidinas/química
Proteínas tau/análise
[Mh] Termos MeSH secundário: Animais
Radioisótopos de Carbono/farmacocinética
Radioisótopos de Flúor/farmacocinética
Seres Humanos
Masculino
Camundongos
Papio
Pirimidinas/farmacocinética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbon Radioisotopes); 0 (Fluorine Radioisotopes); 0 (Pyrimidines); 0 (tau Proteins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jmedchem.7b00632


  6 / 10824 MEDLINE  
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[PMID]:28614669
[Au] Autor:Reyes LF; Restrepo MI; Hinojosa CA; Soni NJ; Anzueto A; Babu BL; Gonzalez-Juarbe N; Rodriguez AH; Jimenez A; Chalmers JD; Aliberti S; Sibila O; Winter VT; Coalson JJ; Giavedoni LD; Dela Cruz CS; Waterer GW; Witzenrath M; Suttorp N; Dube PH; Orihuela CJ
[Ad] Endereço:1 Division of Pulmonary Diseases and Critical Care Medicine.
[Ti] Título:Severe Pneumococcal Pneumonia Causes Acute Cardiac Toxicity and Subsequent Cardiac Remodeling.
[So] Source:Am J Respir Crit Care Med;196(5):609-620, 2017 Sep 01.
[Is] ISSN:1535-4970
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Up to one-third of patients hospitalized with pneumococcal pneumonia experience major adverse cardiac events (MACE) during or after pneumonia. In mice, Streptococcus pneumoniae can invade the myocardium, induce cardiomyocyte death, and disrupt cardiac function following bacteremia, but it is unknown whether the same occurs in humans with severe pneumonia. OBJECTIVES: We sought to determine whether S. pneumoniae can (1) translocate the heart, (2) induce cardiomyocyte death, (3) cause MACE, and (4) induce cardiac scar formation after antibiotic treatment during severe pneumonia using a nonhuman primate (NHP) model. METHODS: We examined cardiac tissue from six adult NHPs with severe pneumococcal pneumonia and three uninfected control animals. Three animals were rescued with antibiotics (convalescent animals). Electrocardiographic, echocardiographic, and serum biomarkers of cardiac damage were measured (troponin T, N-terminal pro-brain natriuretic peptide, and heart-type fatty acid binding protein). Histological examination included hematoxylin and eosin staining, immunofluorescence, immunohistochemistry, picrosirius red staining, and transmission electron microscopy. Immunoblots were used to assess the underlying mechanisms. MEASUREMENTS AND MAIN RESULTS: Nonspecific ischemic alterations were detected by electrocardiography and echocardiography. Serum levels of troponin T and heart-type fatty acid binding protein were increased (P < 0.05) after pneumococcal infection in both acutely ill and convalescent NHPs. S. pneumoniae was detected in the myocardium of all NHPs with acute severe pneumonia. Necroptosis and apoptosis were detected in the myocardium of both acutely ill and convalescent NHPs. Evidence of cardiac scar formation was observed only in convalescent animals by transmission electron microscopy and picrosirius red staining. CONCLUSIONS: S. pneumoniae invades the myocardium and induces cardiac injury with necroptosis and apoptosis, followed by cardiac scarring after antibiotic therapy, in an NHP model of severe pneumonia.
[Mh] Termos MeSH primário: Cardiotoxicidade/etiologia
Miocárdio/patologia
Pneumonia Pneumocócica/complicações
Streptococcus pneumoniae/patogenicidade
[Mh] Termos MeSH secundário: Animais
Antibacterianos/uso terapêutico
Western Blotting
Cardiotoxicidade/sangue
Modelos Animais de Doenças
Ecocardiografia
Eletrocardiografia
Proteínas de Ligação a Ácido Graxo/sangue
Feminino
Coração/microbiologia
Masculino
Papio
Pneumonia Pneumocócica/sangue
Pneumonia Pneumocócica/tratamento farmacológico
Troponina T/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Fatty Acid-Binding Proteins); 0 (Troponin T)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171015
[Lr] Data última revisão:
171015
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.1164/rccm.201701-0104OC


  7 / 10824 MEDLINE  
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[PMID]:28535276
[Au] Autor:Locht C; Papin JF; Lecher S; Debrie AS; Thalen M; Solovay K; Rubin K; Mielcarek N
[Ad] Endereço:Institut Pasteur de Lille, Center for Infection and Immunity of Lille.
[Ti] Título:Live Attenuated Pertussis Vaccine BPZE1 Protects Baboons Against Bordetella pertussis Disease and Infection.
[So] Source:J Infect Dis;216(1):117-124, 2017 Jul 01.
[Is] ISSN:1537-6613
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Evidence suggests that the resurgence of pertussis in many industrialized countries may result from the failure of current vaccines to prevent nasopharyngeal colonization by Bordetella pertussis, the principal causative agent of whooping cough. Here, we used a baboon model to test the protective potential of the novel, live attenuated pertussis vaccine candidate BPZE1. A single intranasal/intratracheal inoculation of juvenile baboons with BPZE1 resulted in transient nasopharyngeal colonization and induction of immunoglobulin G and immunoglobulin A to all antigens tested, while causing no adverse symptoms or leukocytosis. When BPZE1-vaccinated baboons were challenged with a high dose of a highly virulent B. pertussis isolate, they were fully protected against disease, whereas naive baboons developed illness (with 1 death) and leukocytosis. Total postchallenge nasopharyngeal virulent bacterial burden of vaccinated animals was substantially reduced (0.002%) compared to naive controls, providing promising evidence in nonhuman primates that BPZE1 protects against both pertussis disease and B. pertussis infection.
[Mh] Termos MeSH primário: Papio/imunologia
Vacina contra Coqueluche/administração & dosagem
Coqueluche/prevenção & controle
[Mh] Termos MeSH secundário: Animais
Anticorpos Antibacterianos/sangue
Antígenos de Bactérias/sangue
Bordetella pertussis
Modelos Animais de Doenças
Imunoglobulina A/sangue
Imunoglobulina G/sangue
Modelos Moleculares
Papio/microbiologia
Vacina contra Coqueluche/imunologia
Vacinas Atenuadas/administração & dosagem
Vacinas Atenuadas/imunologia
Coqueluche/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Bacterial); 0 (Antigens, Bacterial); 0 (Immunoglobulin A); 0 (Immunoglobulin G); 0 (Pertussis Vaccine); 0 (Vaccines, Attenuated)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE
[do] DOI:10.1093/infdis/jix254


  8 / 10824 MEDLINE  
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[PMID]:28424342
[Au] Autor:Farine DR; Strandburg-Peshkin A; Couzin ID; Berger-Wolf TY; Crofoot MC
[Ad] Endereço:Department of Anthropology, University of California, 1 Shields Avenue, Davis, CA, USA damien.farine@orn.mpg.de.
[Ti] Título:Individual variation in local interaction rules can explain emergent patterns of spatial organization in wild baboons.
[So] Source:Proc Biol Sci;284(1853), 2017 Apr 26.
[Is] ISSN:1471-2954
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Researchers have long noted that individuals occupy consistent spatial positions within animal groups. However, an individual's position depends not only on its own behaviour, but also on the behaviour of others. Theoretical models of collective motion suggest that global patterns of spatial assortment can arise from individual variation in local interaction rules. However, this prediction remains untested. Using high-resolution GPS tracking of members of a wild baboon troop, we identify consistent inter-individual differences in within-group spatial positioning. We then apply an algorithm that identifies what number of conspecific group members best predicts the future location of each individual (we call this the individual's ) while the troop is moving. We find clear variation in the most predictive neighbourhood size, and this variation relates to individuals' propensity to be found near the centre of their group. Using simulations, we show that having different neighbourhood sizes is a simple candidate mechanism capable of linking variation in local individual interaction rules-in this case how many conspecifics an individual interacts with-to global patterns of spatial organization, consistent with the patterns we observe in wild primates and a range of other organisms.
[Mh] Termos MeSH primário: Comportamento Animal
Papio/psicologia
Comportamento Social
[Mh] Termos MeSH secundário: Algoritmos
Animais
Feminino
Sistemas de Informação Geográfica
Quênia
Masculino
Modelos Teóricos
Papio/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170622
[Lr] Data última revisão:
170622
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170421
[St] Status:MEDLINE


  9 / 10824 MEDLINE  
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[PMID]:28421681
[Au] Autor:Cooper DKC
[Ad] Endereço:Xenotransplantation Program, Department of Surgery, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.
[Ti] Título:Early clinical xenotransplantation experiences-An interview with Thomas E. Starzl, MD, PhD.
[So] Source:Xenotransplantation;24(2), 2017 Mar.
[Is] ISSN:1399-3089
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:Dr Thomas E. Starzl, who died on March 4, 2017, was one of the great pioneers of organ transplantation. He was also a pioneer in the field of xenotransplantation. In 1964, he carried out baboon kidney transplants in six patients with terminal renal disease for whom no living or deceased donor became available; graft survival was for 19-60 days, the grafts being lost largely through continuous complement activation. Between 1966 and 1974, he carried out one ex vivo liver perfusion and three orthotopic liver transplants using chimpanzees as sources of organs; graft survival was for <14 days. In 1992 and 1993, his team carried out baboon liver transplantation in two patients with cirrhosis from hepatitis B infection; graft survival was for 70 and 26 days, respectively. This early clinical experience is briefly discussed. Toward the end of his life, Dr Starzl was somewhat disillusioned by what he considered excessive regulation of medical research in the United States and believed that new advances were now likely to take place in countries such as China, where the regulatory framework is less developed.
[Mh] Termos MeSH primário: Sobrevivência de Enxerto
Transplante de Rim
Transplante de Fígado
Obtenção de Tecidos e Órgãos
Transplante Heterólogo
[Mh] Termos MeSH secundário: Animais
China
Seres Humanos
Transplante de Rim/métodos
Transplante de Fígado/métodos
Papio
Obtenção de Tecidos e Órgãos/legislação & jurisprudência
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE
[do] DOI:10.1111/xen.12306


  10 / 10824 MEDLINE  
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[PMID]:28406373
[Au] Autor:Piantadosi ST; Cantlon JF
[Ad] Endereço:Department of Brain and Cognitive Sciences, University of Rochester.
[Ti] Título:True Numerical Cognition in the Wild.
[So] Source:Psychol Sci;28(4):462-469, 2017 Apr.
[Is] ISSN:1467-9280
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cognitive and neural research over the past few decades has produced sophisticated models of the representations and algorithms underlying numerical reasoning in humans and other animals. These models make precise predictions for how humans and other animals should behave when faced with quantitative decisions, yet primarily have been tested only in laboratory tasks. We used data from wild baboons' troop movements recently reported by Strandburg-Peshkin, Farine, Couzin, and Crofoot (2015) to compare a variety of models of quantitative decision making. We found that the decisions made by these naturally behaving wild animals rely specifically on numerical representations that have key homologies with the psychophysics of human number representations. These findings provide important new data on the types of problems human numerical cognition was designed to solve and constitute the first robust evidence of true numerical reasoning in wild animals.
[Mh] Termos MeSH primário: Comportamento Animal/fisiologia
Cognição/fisiologia
Tomada de Decisões/fisiologia
Conceitos Matemáticos
Papio/fisiologia
[Mh] Termos MeSH secundário: Animais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170510
[Lr] Data última revisão:
170510
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE
[do] DOI:10.1177/0956797616686862



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