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  1 / 189 MEDLINE  
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[PMID]:28478775
[Au] Autor:Olarinmoye AO; Olugasa BO; Niphuis H; Herwijnen RV; Verschoor E; Boug A; Ishola OO; Buitendijk H; Fagrouch Z; Al-Hezaimi K
[Ad] Endereço:Engineer Abdullah Bugshan Research Chair for Growth Factors and Bone Regeneration (GFBR),King Saud University,Riyadh,Saudi Arabia.
[Ti] Título:Serological evidence of coronavirus infections in native hamadryas baboons (Papio hamadryas hamadryas) of the Kingdom of Saudi Arabia.
[So] Source:Epidemiol Infect;145(10):2030-2037, 2017 07.
[Is] ISSN:1469-4409
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The hamadryas baboon (Papio hamadryas hamadryas) is the only indigenous species of non-human primates (NHP) found in the Kingdom of Saudi Arabia (KSA). There are no peer-reviewed publications on viral infections of the baboons of KSA. Apart from camels, other animals are likely sources of the novel Middle East Respiratory Syndrome coronavirus (MERSCoV) for humans. We investigated evidence of highly pathogenic coronavirus infections including MERSCoV in a large group of commensal baboons accompanied by feral dogs, on the outskirts of Ta'if city, KSA, in February 2013. Fifty baboons (16 juveniles and 34 adults) were screened for serum antibodies to human coronaviruses (HCoV-043/-NL63/-229) and canine coronaviruses (CCoV-1-3) using direct Enzyme-linked Immunosorbent Assay (ELISA) technique and for MERSCoV antibodies using Serum Neutralization Test (SNT). Of the 50 sampled baboons, 22% (n = 11) were seropositive to HCoVs, 10% (n = 5) were seropositive to CCoVs, while none had detectable MERSCoV antibodies. These findings bear potentially significant implications for public health, canine health and baboon conservation efforts, necessitating follow-up investigations and preventive measures at locations where baboons frequent human habitations, or are regarded as tourist attractions, in KSA.
[Mh] Termos MeSH primário: Infecções por Coronavirus/veterinária
Coronavirus/isolamento & purificação
Doenças dos Macacos/epidemiologia
Papio hamadryas
[Mh] Termos MeSH secundário: Animais
Infecções por Coronavirus/epidemiologia
Infecções por Coronavirus/virologia
Feminino
Masculino
Coronavírus da Síndrome Respiratória do Oriente Médio/isolamento & purificação
Doenças dos Macacos/virologia
Prevalência
Arábia Saudita/epidemiologia
Estudos Soroepidemiológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE
[do] DOI:10.1017/S0950268817000905


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[PMID]:28283262
[Au] Autor:Shockley M; Arnolds K; Beran B; Rivas K; Escobar P; Tzakis A; Falcone T; Sprague ML; Zimberg S
[Ad] Endereço:Department of Gynecology, Cleveland Clinic Florida, Weston, Florida. Electronic address: shocklm@ccf.org.
[Ti] Título:Uterine viability in the baboon after ligation of uterine vasculature: a pilot study to assess alternative perfusion and venous return for uterine transplantation.
[So] Source:Fertil Steril;107(4):1078-1082, 2017 Apr.
[Is] ISSN:1556-5653
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To assess, in two separate groups of baboons, uterine viability after ligation of the uterine veins and uterine viability after ligation of both the uterine arteries and veins, respectively. DESIGN: Prospective, observational study. SETTING: Baboon breeding colony. ANIMAL(S): Six naïve female Papio hamadryas baboons with indicators of normal reproductive function. INTERVENTION(S): Three baboons underwent surgical interruption of the uterine veins bilaterally, and three baboons underwent surgical interruption of the uterine arteries and the uterine veins bilaterally. All baboons also underwent colpotomy, cervico-vaginal reanastomosis, and intraoperative near-infrared fluorescence imaging after vessel ligation. In the postoperative period, transabdominal sonography, vaginoscopy, and endocervical biopsy were performed on all animals. MAIN OUTCOME MEASURE(S): Postoperative uterine and ovarian viability. RESULT(S): Near-infrared imaging confirmed intraoperative perfusion of the uterus and cervico-vaginal anastomosis in all cases. In all subjects, sonography revealed normal uteri, and vaginoscopy revealed well-healed anastomoses. Endocervical biopsies (five of six) demonstrated pathologically normal endocervical tissue without evidence of necrosis. Cyclical sex skin turgescence and menstruation were unanimously observed. CONCLUSION(S): Disruption of bilateral uterine vessels does not affect uterine or ovarian viability in the baboon. Bilateral uterine artery and vein ligation furthers development of a minimally invasive approach to donor hysterectomy.
[Mh] Termos MeSH primário: Histerectomia/métodos
Ovário/cirurgia
Artéria Uterina/transplante
Útero/irrigação sanguínea
Útero/transplante
Veias/transplante
[Mh] Termos MeSH secundário: Animais
Feminino
Histerectomia/efeitos adversos
Ligadura
Modelos Animais
Necrose
Ovário/diagnóstico por imagem
Ovário/patologia
Papio hamadryas
Imagem de Perfusão
Projetos Piloto
Fluxo Sanguíneo Regional
Sobrevivência de Tecidos
Artéria Uterina/diagnóstico por imagem
Útero/diagnóstico por imagem
Útero/patologia
Veias/diagnóstico por imagem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170312
[St] Status:MEDLINE


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[PMID]:28130881
[Au] Autor:Iwase H; Liu H; Schmelzer E; Ezzelarab M; Wijkstrom M; Hara H; Lee W; Singh J; Long C; Lagasse E; Gerlach JC; Cooper DKC; Gridelli B
[Ad] Endereço:Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA.
[Ti] Título:Transplantation of hepatocytes from genetically engineered pigs into baboons.
[So] Source:Xenotransplantation;24(2), 2017 Mar.
[Is] ISSN:1399-3089
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Some patients with acute or acute-on-chronic hepatic failure die before a suitable human liver allograft becomes available. Encouraging results have been achieved in such patients by the transplantation of human hepatocyte progenitor cells from fetal liver tissue. The aim of the study was to explore survival of hepatocytes from genetically engineered pigs after direct injection into the spleen and other selected sites in immunosuppressed baboons to monitor the immune response and the metabolic function and survival of the transplanted hepatocytes. METHODS: Baboons (n=3) were recipients of GTKO/hCD46 pig hepatocytes. All three baboons received anti-thymocyte globulin (ATG) induction and tapering methylprednisolone. Baboon 1 received maintenance immunosuppressive therapy with tacrolimus and rapamycin. Baboons 2 and 3 received an anti-CD40mAb/rapamycin-based regimen that prevents sensitization to pig solid organ grafts. The baboons were euthanized 4 or 5 weeks after hepatocyte transplantation. The baboon immune response was monitored by the measurement of anti-non-Gal IgM and IgG antibodies (by flow cytometry) and CFSE-mixed lymphocyte reaction. Monitoring for hepatocyte survival and function was by (i) real-time PCR detection of porcine DNA, (ii) real-time PCR for porcine gene expression, and (iii) pig serum albumin levels (by ELISA). The sites of hepatocyte injection were examined microscopically. RESULTS: Detection of porcine DNA and porcine gene expression was minimal at all sites of hepatocyte injection. Serum levels of porcine albumen were very low-500-1000-fold lower than in baboons with orthotopic pig liver grafts, and approximately 5000-fold lower than in healthy pigs. No hepatocytes or infiltrating immune cells were seen at any of the injection sites. Two baboons (Baboons 1 and 3) demonstrated a significant increase in anti-pig IgM and an even greater increase in IgG, indicating sensitization to pig antigens. DISCUSSION AND CONCLUSIONS: As a result of this disappointing experience, the following points need to be considered. (i) Were the isolated pig hepatocytes functionally viable? (ii) Are pig hepatocytes more immunogenic than pig hearts, kidneys, artery patch grafts, or islets? (iii) Does injection of pig cells (antigens) into the spleen and/or lymph nodes stimulate a greater immune response than when pig tissues are grafted at other sites? (iv) Did the presence of the recipient's intact liver prevent survival and proliferation of pig hepatocytes? (v) Is pig CD47-primate SIRP-α compatibility essential? In conclusion, the transplantation of genetically engineered pig hepatocytes into multiple sites in immunosuppressed baboons was associated with very early graft failure. Considerable further study is required before clinical trials should be undertaken.
[Mh] Termos MeSH primário: Sobrevivência de Enxerto/imunologia
Hepatócitos/imunologia
Transplante Heterólogo
[Mh] Termos MeSH secundário: Animais
Animais Geneticamente Modificados
Anticorpos/imunologia
Formação de Anticorpos/genética
Formação de Anticorpos/imunologia
Antígenos/imunologia
Sobrevivência de Enxerto/efeitos dos fármacos
Hepatócitos/transplante
Imunossupressão/métodos
Imunossupressores/farmacologia
Papio hamadryas/imunologia
Suínos
Transplante Heterólogo/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies); 0 (Antigens); 0 (Immunosuppressive Agents)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170129
[St] Status:MEDLINE
[do] DOI:10.1111/xen.12289


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[PMID]:27726166
[Au] Autor:Chai D; Bassis CM; Bergin IL; Bell JD; Nyachieo A; Gathumbi PK
[Ad] Endereço:Department of Animal Sciences, Institute of Primate Research, National Museums of Kenya, Karen, Nairobi, Kenya.
[Ti] Título:Prevalence and geographical distribution of Papio hamadryas papillomavirus 1 (PhPV1) in Kenyan baboons.
[So] Source:J Med Primatol;46(1):13-15, 2017 Feb.
[Is] ISSN:1600-0684
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:Papio hamadryas papillomavirus (PhPV) 1, 2, and 3, are Alphapapillomaviruses that have been detected in Kenyan Olive baboons but the distribution is unknown. Therefore, cervical screening for PhPV1 was performed in baboons from various areas in Kenya using a nested polymerase chain reaction. The prevalence rate was 33%.
[Mh] Termos MeSH primário: Doenças dos Macacos/epidemiologia
Papillomaviridae/isolamento & purificação
Infecções por Papillomavirus/veterinária
Papio hamadryas
[Mh] Termos MeSH secundário: Animais
Feminino
Quênia/epidemiologia
Doenças dos Macacos/virologia
Papillomaviridae/genética
Infecções por Papillomavirus/epidemiologia
Infecções por Papillomavirus/virologia
Prevalência
Análise de Sequência de DNA/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161012
[St] Status:MEDLINE
[do] DOI:10.1111/jmp.12247


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[PMID]:27473331
[Au] Autor:Goodwin AK
[Ad] Endereço:Division of Neurotoxicology, National Center for Toxicological Research, US Food & Drug Administration, United States; Department of Psychiatry and Behavioral Sciences, Division of Behavioral Biology, Johns Hopkins University School of Medicine, United States. Electronic address: Amy.Goodwin@FDA.HHS.GOV.
[Ti] Título:An intravenous self-administration procedure for assessing the reinforcing effects of hallucinogens in nonhuman primates.
[So] Source:J Pharmacol Toxicol Methods;82:31-36, 2016 Nov - Dec.
[Is] ISSN:1873-488X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Self-administration procedures are the gold standard for investigating the reinforcing effects of drugs. The notable exception to good correspondence between laboratory self-administration studies and human drug taking behavior has historically been the classic hallucinogens. METHOD: The present study used a well-established daily access procedure, followed by a novel intermittent access procedure, to investigate the reinforcing effects of LSD in baboons. RESULTS: Rates of self-injection in the daily access procedure were minimal. One baboon self-administered 0.001mg/kg and a second baboon self-administered 0.0032mg/kg above vehicle levels, though rates of self-injection were clearly low and neither of the two remaining baboons self-administered any LSD dose tested in the daily access procedure. Rates of self-injection using an intermittent access procedure with discriminative stimuli resulted in two doses of LSD being self-administered above vehicle levels in two of three baboons tested (0.01 and 0.032mg/kg in one baboon; 0.0032 and 0.01mg/kg in a second). In addition, the number of self-injections at these doses was higher (range=3-6 injections) in the intermittent access procedure than in the daily access procedure (range=1-2 injections). DISCUSSION: The present study is the first to demonstrate LSD self-administration in a laboratory animal, and though the results are limited, they indicate intermittent access procedures with discriminative stimuli may provide a reliable and valid method for investigating the reinforcing effects of IV self-administered hallucinogens in laboratory animals. The usefulness of such procedures should be further evaluated in a larger number of subjects.
[Mh] Termos MeSH primário: Comportamento Aditivo/psicologia
Condicionamento Operante/efeitos dos fármacos
Alucinógenos/administração & dosagem
Dietilamida do Ácido Lisérgico/administração & dosagem
Reforço (Psicologia)
[Mh] Termos MeSH secundário: Animais
Injeções Intravenosas
Papio hamadryas
Esquema de Reforço
Autoadministração
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hallucinogens); 8NA5SWF92O (Lysergic Acid Diethylamide)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160731
[St] Status:MEDLINE


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[PMID]:26828857
[Au] Autor:Ryan AM; Hauber ME
[Ad] Endereço:Program in Animal Behavior and Conservation, Department of Psychology, Hunter College of the City University of New York, New York, New York.
[Ti] Título:Group compositional changes impact the social and feeding behaviors of captive hamadryas baboons (Papio hamadryas hamadryas).
[So] Source:Zoo Biol;35(2):137-46, 2016 Mar-Apr.
[Is] ISSN:1098-2361
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The formation and modification of social groups in captivity are delicate management tasks. The ability for personnel to anticipate changes in group dynamics following compositional changes can increase the likelihood of successful management with minimized injury or social instability. Hamadryas baboons (Papio hamadryas hamadryas) have a distinctive multi-level social system comprising of one-male units (OMUs) that can make it difficult to apply knowledge from other primates' multi-female/multi-male social structure to changes imposed onto captive hamadryas baboon groups. We conducted an observational study of the behavioral impacts following the introduction of two females into the group of hamadryas baboons at the Wildlife Conservation Society's Prospect Park Zoo in NY to test hypotheses about the relationships between changes in group composition and social and feeding behavior. Generalized linear mixed models demonstrated that social interactions significantly increased following the compositional changes, even in groups that only experienced member removals. The increase in affiliative social behavior observed suggests that during times of social stress or uncertainty, hamadryas baboons may employ social behavior as a tension-reducing mechanism to negotiate relationships as opposed to using aggression to engage in competitions for ranks and resources. The observed response to compositional changes implies that hamadryas baboons may respond with less aggression than do other Old World monkey species and that levels of affiliative behavior may be a more accurate metric for evaluating introduction success in hamadryas baboons.
[Mh] Termos MeSH primário: Animais de Zoológico/fisiologia
Comportamento Alimentar/fisiologia
Papio hamadryas/fisiologia
Comportamento Social
[Mh] Termos MeSH secundário: Animais
Animais de Zoológico/psicologia
Feminino
Modelos Lineares
Masculino
Papio hamadryas/psicologia
Dinâmica Populacional
Estresse Psicológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160411
[Lr] Data última revisão:
160411
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160202
[St] Status:MEDLINE
[do] DOI:10.1002/zoo.21264


  7 / 189 MEDLINE  
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[PMID]:26780314
[Au] Autor:Augusteyn RC; Maceo Heilman B; Ho A; Parel JM
[Ad] Endereço:Vision Cooperative Research Centre, Sydney, Australia 2School of Optometry and Vision Science, University of New South Wales, Sydney, Australia 3Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miam.
[Ti] Título:Nonhuman Primate Ocular Biometry.
[So] Source:Invest Ophthalmol Vis Sci;57(1):105-14, 2016 Jan 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To examine ocular growth in nonhuman primates (NHPs) from measurements on ex vivo eyes. METHODS: We obtained NHP eyes from animals that had been killed as part of other studies or because of health-related issues. Digital calipers were used to measure the horizontal, vertical, and anteroposterior globe diameters as well as corneal horizontal and vertical diameters of excised globes from 98 hamadryas baboons, 551 cynomolgus monkeys, and 112 rhesus monkeys, at ages ranging from 23 to 360 months. Isolated lens sagittal thickness and equatorial diameter were measured by shadowphotogrammetry. Wet and fixed dry weights were obtained for lenses. RESULTS: Nonhuman primate globe growth continues throughout life, slowing toward an asymptotic maximum. The final globe size scales with negative allometry to adult body size. Corneal growth ceases at around 20 months. Lens diameter increases but thickness decreases with increasing age. Nonhuman primate lens wet and dry weight accumulation is monophasic, continuing throughout life toward asymptotic maxima. The dry/wet weight ratio reaches a maximum of 0.33. CONCLUSIONS: Nonhuman primate ocular globe and lens growth differ in several respects from those in humans. Although age-related losses of lens power and accommodative amplitude are similar, lens growth and properties are different indicating care should be taken in extrapolating NHP observations to the study of human accommodation.
[Mh] Termos MeSH primário: Envelhecimento
Biometria/métodos
Córnea/crescimento & desenvolvimento
Cristalino/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Animais
Macaca fascicularis
Macaca mulatta
Papio hamadryas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1605
[Cu] Atualização por classe:161019
[Lr] Data última revisão:
161019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160119
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.15-18169


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[PMID]:26471255
[Au] Autor:Rojas C; Alt J; Ator NA; Thomas AG; Wu Y; Hin N; Wozniak K; Ferraris D; Rais R; Tsukamoto T; Slusher BS
[Ad] Endereço:Johns Hopkins Drug Discovery, Baltimore, MD, USA.
[Ti] Título:D-Amino-Acid Oxidase Inhibition Increases D-Serine Plasma Levels in Mouse But not in Monkey or Dog.
[So] Source:Neuropsychopharmacology;41(6):1610-9, 2016 May.
[Is] ISSN:1740-634X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:D-serine has been shown to improve positive, negative, and cognitive symptoms when used as add-on therapy for the treatment of schizophrenia. However, D-serine has to be administered at high doses to observe clinical effects. This is thought to be due to D-serine undergoing oxidation by D-amino-acid oxidase (DAAO) before it reaches the brain. Consequently, co-administration of D-serine with a DAAO inhibitor could be a way to lower the D-serine dose required to treat schizophrenia. Early studies in rodents to evaluate this hypothesis showed that concomitant administration of structurally distinct DAAO inhibitors with D-serine enhanced plasma and brain D-serine levels in rodents compared with administration of D-serine alone. In the present work we used three potent DAAO inhibitors and confirmed previous results in mice. In a follow-up effort, we evaluated plasma D-serine levels in monkeys after oral administration of D-serine in the presence or absence of these DAAO inhibitors. Even though the compounds reached steady state plasma concentrations exceeding their Ki values by >60-fold, plasma D-serine levels remained the same as those in the absence of DAAO inhibitors. Similar results were obtained with dogs. In summary, in contrast to rodents, DAAO inhibition in monkeys and dogs did not influence the exposure to exogenously administered D-serine. Results could be due to differences in D-serine metabolism and/or clearance mechanisms and suggest that the role of DAAO in the metabolism of D-serine is different across species. These data provide caution regarding the utility of DAAO inhibition for patients with schizophrenia.
[Mh] Termos MeSH primário: D-Aminoácido Oxidase/antagonistas & inibidores
Serina/sangue
[Mh] Termos MeSH secundário: Animais
D-Aminoácido Oxidase/metabolismo
Cães
Isoxazóis/farmacologia
Masculino
Camundongos
Papio hamadryas
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (5-chlorobenzo(d)isoxazol-3-ol); 0 (Isoxazoles); 452VLY9402 (Serine); EC 1.4.3.3 (D-Amino-Acid Oxidase)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170502
[Lr] Data última revisão:
170502
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151017
[St] Status:MEDLINE
[do] DOI:10.1038/npp.2015.319


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[PMID]:25749860
[Au] Autor:Ákos Szabó C; Salinas FS; Li K; Franklin C; Leland MM; Fox PT; Laird AR; Narayana S
[Ad] Endereço:Department of Neurology, South Texas Comprehensive Epilepsy Center, University of Texas Health Science Center San Antonio, 8300 Floyd Curl Drive, San Antonio, TX, 78229-7883, USA. szabo@uthscsa.edu.
[Ti] Título:Modeling the effective connectivity of the visual network in healthy and photosensitive, epileptic baboons.
[So] Source:Brain Struct Funct;221(4):2023-33, 2016 May.
[Is] ISSN:1863-2661
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The baboon provides a model of photosensitive, generalized epilepsy. This study compares cerebral blood flow responses during intermittent light stimulation (ILS) between photosensitive (PS) and healthy control (CTL) baboons using H 2 (15) O-PET. We examined effective connectivity associated with visual stimulation in both groups using structural equation modeling (SEM). Eight PS and six CTL baboons, matched for age, gender and weight, were classified on the basis of scalp EEG findings performed during the neuroimaging studies. Five H 2 (15) O-PET studies were acquired alternating between resting and activation (ILS at 25 Hz) scans. PET images were acquired in 3D mode and co-registered with MRI. SEM demonstrated differences in neural connectivity between PS and CTL groups during ILS that were not previously identified using traditional activation analyses. First-level pathways consisted of similar posterior-to-anterior projections in both groups. While second-level pathways were mainly lateralized to the left hemisphere in the CTL group, they consisted of bilateral anterior-to-posterior projections in the PS baboons. Third- and fourth-level pathways were only evident in PS baboons. This is the first functional neuroimaging study used to model the photoparoxysmal response (PPR) using a primate model of photosensitive, generalized epilepsy. Evidence of increased interhemispheric connectivity and bidirectional feedback loops in the PS baboons represents electrophysiological synchronization associated with the generation of epileptic discharges. PS baboons demonstrated decreased model stability compared to controls, which may be attributed to greater variability in the driving response or PPRs, or to the influence of regions not included in the model.
[Mh] Termos MeSH primário: Epilepsia Generalizada/fisiopatologia
Epilepsia Reflexa/fisiopatologia
Córtex Visual/fisiologia
Córtex Visual/fisiopatologia
Vias Visuais/fisiologia
Vias Visuais/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Córtex Cerebral/fisiologia
Córtex Cerebral/fisiopatologia
Eletroencefalografia
Feminino
Imagem por Ressonância Magnética
Masculino
Papio anubis
Papio hamadryas
Estimulação Luminosa
Tomografia por Emissão de Pósitrons
Processamento de Sinais Assistido por Computador
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150310
[St] Status:MEDLINE
[do] DOI:10.1007/s00429-015-1022-y


  10 / 189 MEDLINE  
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[PMID]:26287673
[Au] Autor:Gilbert CC; Steininger CM; Kibii JM; Berger LR
[Ad] Endereço:Department of Anthropology, Hunter College of the City University of New York, 695 Park Avenue, New York, NY, 10065, United States of America; PhD Programs in Anthropology and Biology, Graduate Center of the City University of New York, 365 Fifth Avenue, New York, NY, 10016, United States of America
[Ti] Título:Papio Cranium from the Hominin-Bearing Site of Malapa: Implications for the Evolution of Modern Baboon Cranial Morphology and South African Plio-Pleistocene Biochronology.
[So] Source:PLoS One;10(8):e0133361, 2015.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A new partial cranium (UW 88-886) of the Plio-Pleistocene baboon Papio angusticeps from Malapa is identified, described and discussed. UW 88-886 represents the only non-hominin primate yet recovered from Malapa and is important both in the context of baboon evolution as well as South African hominin site biochronology. The new specimen may represent the first appearance of modern baboon anatomy and coincides almost perfectly with molecular divergence date estimates for the origin of the modern P. hamadryas radiation. The fact that the Malapa specimen is dated between ~2.026-2.36 million years ago (Ma) also has implications for the biochronology of other South African Plio-Pleistocene sites where P. angusticeps is found.
[Mh] Termos MeSH primário: Hominidae/anatomia & histologia
Papio hamadryas/anatomia & histologia
Papio/anatomia & histologia
Crânio/anatomia & histologia
[Mh] Termos MeSH secundário: Animais
Evolução Biológica
Fósseis/anatomia & histologia
Cabeça/anatomia & histologia
África do Sul
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1605
[Cu] Atualização por classe:150902
[Lr] Data última revisão:
150902
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150820
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0133361



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