[PMID]: | 28348269 |
[Au] Autor: | Wroblewski EE; Guethlein LA; Norman PJ; Li Y; Shaw CM; Han AS; Ndjango JN; Ahuka-Mundeke S; Georgiev AV; Peeters M; Hahn BH; Parham P |
[Ad] Endereço: | Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305; eewro1@stanford.edu peropa@stanford.edu. |
[Ti] Título: | Bonobos Maintain Immune System Diversity with Three Functional Types of MHC-B. |
[So] Source: | J Immunol;198(9):3480-3493, 2017 May 01. |
[Is] ISSN: | 1550-6606 |
[Cp] País de publicação: | United States |
[La] Idioma: | eng |
[Ab] Resumo: | Fast-evolving MHC class I polymorphism serves to diversify NK cell and CD8 T cell responses in individuals, families, and populations. Because only chimpanzee and bonobo have strict orthologs of all , their study gives unique perspectives on the human condition. We defined polymorphism of , the bonobo ortholog of , for six wild bonobo populations. Sequences for exon 2 and 3 were determined from the genomic DNA in 255 fecal samples, minimally representing 110 individuals. Twenty-two alleles were defined, each encoding a different Papa-B protein. No Papa-B is identical to any chimpanzee Patr-B, human HLA-B, or gorilla Gogo-B. Phylogenetic analysis identified a clade of MHC-B, defined by residues 45-74 of the α domain, which is broadly conserved among bonobo, chimpanzee, and gorilla. Bonobo populations have 3-14 Papa-B allotypes. Three Papa-B are in all populations, and they are each of a different functional type: allotypes having the Bw4 epitope recognized by killer cell Ig-like receptors of NK cells, allotypes having the C1 epitope also recognized by killer cell Ig-like receptors, and allotypes having neither epitope. For population Malebo, these three Papa-B are the only Papa-B allotypes. Although small in number, their sequence divergence is such that the nucleotide diversity (mean proportional distance) of in Malebo is greater than in the other populations and is also greater than expected for random combinations of three Overall, has substantially less diversity than in chimpanzee subspecies and in indigenous human populations, consistent with bonobo having experienced narrower population bottlenecks. |
[Mh] Termos MeSH primário: |
Antígenos de Histocompatibilidade Classe I/genética Sistema Imunitário Epitopos Imunodominantes/genética Células Matadoras Naturais/imunologia Pan paniscus
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[Mh] Termos MeSH secundário: |
Animais Evolução Biológica Frequência do Gene Genótipo Gorilla gorilla Antígenos HLA-B/genética Seres Humanos Pan troglodytes Filogenia Polimorfismo Genético
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[Pt] Tipo de publicação: | COMPARATIVE STUDY; JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (HLA-B Antigens); 0 (Histocompatibility Antigens Class I); 0 (Immunodominant Epitopes) |
[Em] Mês de entrada: | 1705 |
[Cu] Atualização por classe: | 171107 |
[Lr] Data última revisão:
| 171107 |
[Sb] Subgrupo de revista: | AIM; IM |
[Da] Data de entrada para processamento: | 170329 |
[St] Status: | MEDLINE |
[do] DOI: | 10.4049/jimmunol.1601955 |
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