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  1 / 197 MEDLINE  
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[PMID]:28323346
[Au] Autor:Schneider C; Liebal K; Call J
[Ad] Endereço:School of Psychology, University of East London, London, UK.
[Ti] Título:"Giving" and "responding" differences in gestural communication between nonhuman great ape mothers and infants.
[So] Source:Dev Psychobiol;59(3):303-313, 2017 04.
[Is] ISSN:1098-2302
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In the first comparative analysis of its kind, we investigated gesture behavior and response patterns in 25 captive ape mother-infant dyads (six bonobos, eight chimpanzees, three gorillas, and eight orangutans). We examined (i) how frequently mothers and infants gestured to each other and to other group members; and (ii) to what extent infants and mothers responded to the gestural attempts of others. Our findings confirmed the hypothesis that bonobo mothers were more proactive in their gesturing to their infants than the other species. Yet mothers (from all four species) often did not respond to the gestures of their infants and other group members. In contrast, infants "pervasively" responded to gestures they received from their mothers and other group members. We propose that infants' pervasive responsiveness rather than the quality of mother investment and her responsiveness may be crucial to communication development in nonhuman great apes.
[Mh] Termos MeSH primário: Comunicação Animal
Gestos
Hominidae/fisiologia
Mães
[Mh] Termos MeSH secundário: Animais
Feminino
Gorilla gorilla
Pan paniscus
Pan troglodytes
Pongo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1002/dev.21495


  2 / 197 MEDLINE  
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[PMID]:28282382
[Au] Autor:McManus KF; Taravella AM; Henn BM; Bustamante CD; Sikora M; Cornejo OE
[Ad] Endereço:Department of Biology, Stanford University, Stanford, California, United States of America.
[Ti] Título:Population genetic analysis of the DARC locus (Duffy) reveals adaptation from standing variation associated with malaria resistance in humans.
[So] Source:PLoS Genet;13(3):e1006560, 2017 Mar.
[Is] ISSN:1553-7404
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The human DARC (Duffy antigen receptor for chemokines) gene encodes a membrane-bound chemokine receptor crucial for the infection of red blood cells by Plasmodium vivax, a major causative agent of malaria. Of the three major allelic classes segregating in human populations, the FY*O allele has been shown to protect against P. vivax infection and is at near fixation in sub-Saharan Africa, while FY*B and FY*A are common in Europe and Asia, respectively. Due to the combination of strong geographic differentiation and association with malaria resistance, DARC is considered a canonical example of positive selection in humans. Despite this, details of the timing and mode of selection at DARC remain poorly understood. Here, we use sequencing data from over 1,000 individuals in twenty-one human populations, as well as ancient human genomes, to perform a fine-scale investigation of the evolutionary history of DARC. We estimate the time to most recent common ancestor (TMRCA) of the most common FY*O haplotype to be 42 kya (95% CI: 34-49 kya). We infer the FY*O null mutation swept to fixation in Africa from standing variation with very low initial frequency (0.1%) and a selection coefficient of 0.043 (95% CI:0.011-0.18), which is among the strongest estimated in the human genome. We estimate the TMRCA of the FY*A mutation in non-Africans to be 57 kya (95% CI: 48-65 kya) and infer that, prior to the sweep of FY*O, all three alleles were segregating in Africa, as highly diverged populations from Asia and ≠Khomani San hunter-gatherers share the same FY*A haplotypes. We test multiple models of admixture that may account for this observation and reject recent Asian or European admixture as the cause.
[Mh] Termos MeSH primário: Resistência à Doença/genética
Sistema do Grupo Sanguíneo Duffy/genética
Genética Populacional
Malária Vivax/genética
Receptores de Superfície Celular/genética
[Mh] Termos MeSH secundário: África
Alelos
Animais
Ásia
Sistema do Grupo Sanguíneo Duffy/metabolismo
Frequência do Gene
Genoma Humano
Geografia
Gorilla gorilla
Haplótipos
Seres Humanos
Mutação
Pan paniscus
Pan troglodytes
Polimorfismo de Nucleotídeo Único
Pongo
Regiões Promotoras Genéticas
Receptores de Superfície Celular/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DARC protein, human); 0 (Duffy Blood-Group System); 0 (Receptors, Cell Surface)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pgen.1006560


  3 / 197 MEDLINE  
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[PMID]:28264973
[Au] Autor:Guethlein LA; Norman PJ; Heijmans CM; de Groot NG; Hilton HG; Babrzadeh F; Abi-Rached L; Bontrop RE; Parham P
[Ad] Endereço:Department of Structural Biology, Stanford University, Stanford, CA 94305.
[Ti] Título:Two Orangutan Species Have Evolved Different Alleles and Haplotypes.
[So] Source:J Immunol;198(8):3157-3169, 2017 Apr 15.
[Is] ISSN:1550-6606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The immune and reproductive functions of human NK cells are regulated by interactions of the C1 and C2 epitopes of HLA-C with C1-specific and C2-specific lineage III killer cell Ig-like receptors (KIR). This rapidly evolving and diverse system of ligands and receptors is restricted to humans and great apes. In this context, the orangutan has particular relevance because it represents an evolutionary intermediate, one having the C1 epitope and corresponding KIR but lacking the C2 epitope. Through a combination of direct sequencing, genotyping, and data mining from the Great Ape Genome Project, we characterized the alleles and haplotypes for panels of 10 Bornean orangutans and 19 Sumatran orangutans. The orangutan haplotypes have between 5 and 10 genes. The seven orangutan lineage III genes all locate to the centromeric region of the locus, whereas their human counterparts also populate the telomeric region. One lineage III gene is Bornean specific, one is Sumatran specific, and five are shared. Of 12 gene-content haplotypes, 5 are Bornean specific, 5 are Sumatran specific, and 2 are shared. The haplotypes have different combinations of genes encoding activating and inhibitory C1 receptors that can be of higher or lower affinity. All haplotypes encode an inhibitory C1 receptor, but only some haplotypes encode an activating C1 receptor. Of 130 alleles, 55 are Bornean specific, 65 are Sumatran specific, and 10 are shared.
[Mh] Termos MeSH primário: Evolução Molecular
Pongo/genética
Pongo/imunologia
Receptores KIR/genética
[Mh] Termos MeSH secundário: Alelos
Animais
Cromossomos Artificiais Bacterianos
Haplótipos
Filogenia
Reação em Cadeia da Polimerase
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, KIR)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170308
[St] Status:MEDLINE
[do] DOI:10.4049/jimmunol.1602163


  4 / 197 MEDLINE  
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[PMID]:28027315
[Au] Autor:Stabell AC; Hawkins J; Li M; Gao X; David M; Press WH; Sawyer SL
[Ad] Endereço:BioFrontiers Institute, University of Colorado Boulder, Boulder, CO, United States of America.
[Ti] Título:Non-human Primate Schlafen11 Inhibits Production of Both Host and Viral Proteins.
[So] Source:PLoS Pathog;12(12):e1006066, 2016 Dec.
[Is] ISSN:1553-7374
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Schlafen11 (encoded by the SLFN11 gene) has been shown to inhibit the accumulation of HIV-1 proteins. We show that the SLFN11 gene is under positive selection in simian primates and is species-specific in its activity against HIV-1. The activity of human Schlafen11 is relatively weak compared to that of some other primate versions of this protein, with the versions encoded by chimpanzee, orangutan, gibbon, and marmoset being particularly potent inhibitors of HIV-1 protein production. Interestingly, we find that Schlafen11 is functional in the absence of infection and reduces protein production from certain non-viral (GFP) and even host (Vinculin and GAPDH) transcripts. This suggests that Schlafen11 may just generally block protein production from non-codon optimized transcripts. Because Schlafen11 is an interferon-stimulated gene with a broad ability to inhibit protein production from many host and viral transcripts, its role may be to create a general antiviral state in the cell. Interestingly, the strong inhibitors such as marmoset Schlafen11 consistently block protein production better than weak primate Schlafen11 proteins, regardless of the virus or host target being analyzed. Further, we show that the residues to which species-specific differences in Schlafen11 potency map are distinct from residues that have been targeted by positive selection. We speculate that the positive selection of SLFN11 could have been driven by a number of different factors, including interaction with one or more viral antagonists that have yet to be identified.
[Mh] Termos MeSH primário: Evolução Molecular
Proteínas Nucleares/imunologia
Proteínas Virais/imunologia
Viroses/imunologia
[Mh] Termos MeSH secundário: Animais
Callithrix
Citometria de Fluxo
HIV-1/imunologia
Seres Humanos
Hylobates
Immunoblotting
Mutagênese Sítio-Dirigida
Proteínas Nucleares/genética
Pan troglodytes
Reação em Cadeia da Polimerase
Pongo
Primatas
Seleção Genética
Especificidade da Espécie
Transfecção
Proteínas Virais/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nuclear Proteins); 0 (Viral Proteins)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161228
[St] Status:MEDLINE
[do] DOI:10.1371/journal.ppat.1006066


  5 / 197 MEDLINE  
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[PMID]:27977673
[Au] Autor:Harpak A; Bhaskar A; Pritchard JK
[Ad] Endereço:Department of Biology, Stanford University, Stanford, California, United States of America.
[Ti] Título:Mutation Rate Variation is a Primary Determinant of the Distribution of Allele Frequencies in Humans.
[So] Source:PLoS Genet;12(12):e1006489, 2016 Dec.
[Is] ISSN:1553-7404
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The site frequency spectrum (SFS) has long been used to study demographic history and natural selection. Here, we extend this summary by examining the SFS conditional on the alleles found at the same site in other species. We refer to this extension as the "phylogenetically-conditioned SFS" or cSFS. Using recent large-sample data from the Exome Aggregation Consortium (ExAC), combined with primate genome sequences, we find that human variants that occurred independently in closely related primate lineages are at higher frequencies in humans than variants with parallel substitutions in more distant primates. We show that this effect is largely due to sites with elevated mutation rates causing significant departures from the widely-used infinite sites mutation model. Our analysis also suggests substantial variation in mutation rates even among mutations involving the same nucleotide changes. In summary, we show that variable mutation rates are key determinants of the SFS in humans.
[Mh] Termos MeSH primário: Genética Populacional
Taxa de Mutação
Filogenia
Seleção Genética/genética
[Mh] Termos MeSH secundário: Alelos
Substituição de Aminoácidos/genética
Animais
Sequência de Bases
Mapeamento Cromossômico
Metilação de DNA/genética
Exoma/genética
Frequência do Gene/genética
Seres Humanos
Mutação
Pongo/genética
Primatas/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161216
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pgen.1006489


  6 / 197 MEDLINE  
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[PMID]:27870346
[Au] Autor:Wang Q; Dechow PC
[Ad] Endereço:Department of Biomedical Sciences Texas A&M University College of Dentistry, Dallas, Texas.
[Ti] Título:Divided Zygomatic Bone in Primates With Implications of Skull Morphology and Biomechanics.
[So] Source:Anat Rec (Hoboken);299(12):1801-1829, 2016 Dec.
[Is] ISSN:1932-8494
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Typically the zygoma is a single bone in the facial skeleton whose shape uniquely copes with loads associated with mastication. Rarely but naturally, the zygoma is divided into two or more parts by supernumerary sutures. These extra intrazygomatic sutures are located at an area of critical morphological and biomechanical importance, yet their impacts have not been studied. In this study, the morphological and possible biomechanical consequences of the divided zygoma (DZ) were investigated in primates including rhesus macaques (Macaca mulatta), orangutans (Pongo abelii and P. pygmaeus), and modern humans (Homo sapiens). Results demonstrated that a unilateral supernumerary suture within the zygoma affected facial symmetry. The superior division of the divided zygoma was normally slender along with the adjacent frontal bone parts; while the inferior division of the divided zygoma was normally more robust, along with stronger temporal and maxillary bones. These were possible biomechanical consequences, in which the stresses incurred during normal masticatory activities were shunted from the upper face to the lower face, especially along the zygomatic arch. These findings revealed that the DZ condition would alter overall morphology of the midface of the affected side, and unfavorably affect the pattern of stress distribution in the loaded side of the face during mastication. The developmental mechanisms for the supernumerary sutures dividing the zygoma were unclear. Further insights into this rare condition may deepen our understanding of craniofacial form, adaptation, developmental plasticity, and evolution, and help to improve therapeutic philosophies in corrective and regenerative medicine. Anat Rec, 299:1801-1829, 2016. © 2016 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Macaca mulatta/anatomia & histologia
Pongo/anatomia & histologia
Crânio/anatomia & histologia
Zigoma/anatomia & histologia
[Mh] Termos MeSH secundário: Animais
Evolução Biológica
Fenômenos Biomecânicos/fisiologia
Seres Humanos
Macaca mulatta/fisiologia
Pongo/fisiologia
Crânio/fisiologia
Zigoma/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161122
[St] Status:MEDLINE
[do] DOI:10.1002/ar.23448


  7 / 197 MEDLINE  
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[PMID]:27603668
[Au] Autor:Robbins MM; Ando C; Fawcett KA; Grueter CC; Hedwig D; Iwata Y; Lodwick JL; Masi S; Salmi R; Stoinski TS; Todd A; Vercellio V; Yamagiwa J
[Ad] Endereço:Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.
[Ti] Título:Behavioral Variation in Gorillas: Evidence of Potential Cultural Traits.
[So] Source:PLoS One;11(9):e0160483, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The question of whether any species except humans exhibits culture has generated much debate, partially due to the difficulty of providing conclusive evidence from observational studies in the wild. A starting point for demonstrating the existence of culture that has been used for many species including chimpanzees and orangutans is to show that there is geographic variation in the occurrence of particular behavioral traits inferred to be a result of social learning and not ecological or genetic influences. Gorillas live in a wide variety of habitats across Africa and they exhibit flexibility in diet, behavior, and social structure. Here we apply the 'method of exclusion' to look for the presence/absence of behaviors that could be considered potential cultural traits in well-habituated groups from five study sites of the two species of gorillas. Of the 41 behaviors considered, 23 met the criteria of potential cultural traits, of which one was foraging related, nine were environment related, seven involved social interactions, five were gestures, and one was communication related. There was a strong positive correlation between behavioral dissimilarity and geographic distance among gorilla study sites. Roughly half of all variation in potential cultural traits was intraspecific differences (i.e. variability among sites within a species) and the other 50% of potential cultural traits were differences between western and eastern gorillas. Further research is needed to investigate if the occurrence of these traits is influenced by social learning. These findings emphasize the importance of investigating cultural traits in African apes and other species to shed light on the origin of human culture.
[Mh] Termos MeSH primário: Cultura
Comportamento Alimentar/fisiologia
Gorilla gorilla/fisiologia
Comportamento Social
[Mh] Termos MeSH secundário: África
Animais
Ecologia
Feminino
Gorilla gorilla/genética
Relações Interpessoais
Pan troglodytes
Fenótipo
Pongo
Pongo pygmaeus
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160908
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0160483


  8 / 197 MEDLINE  
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[PMID]:27487209
[Au] Autor:Nuttle X; Giannuzzi G; Duyzend MH; Schraiber JG; Narvaiza I; Sudmant PH; Penn O; Chiatante G; Malig M; Huddleston J; Benner C; Camponeschi F; Ciofi-Baffoni S; Stessman HA; Marchetto MC; Denman L; Harshman L; Baker C; Raja A; Penewit K; Janke N; Tang WJ; Ventura M; Banci L; Antonacci F; Akey JM; Amemiya CT; Gage FH; Reymond A; Eichler EE
[Ti] Título:Emergence of a Homo sapiens-specific gene family and chromosome 16p11.2 CNV susceptibility.
[So] Source:Nature;536(7615):205-9, 2016 08 11.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Genetic differences that specify unique aspects of human evolution have typically been identified by comparative analyses between the genomes of humans and closely related primates, including more recently the genomes of archaic hominins. Not all regions of the genome, however, are equally amenable to such study. Recurrent copy number variation (CNV) at chromosome 16p11.2 accounts for approximately 1% of cases of autism and is mediated by a complex set of segmental duplications, many of which arose recently during human evolution. Here we reconstruct the evolutionary history of the locus and identify bolA family member 2 (BOLA2) as a gene duplicated exclusively in Homo sapiens. We estimate that a 95-kilobase-pair segment containing BOLA2 duplicated across the critical region approximately 282 thousand years ago (ka), one of the latest among a series of genomic changes that dramatically restructured the locus during hominid evolution. All humans examined carried one or more copies of the duplication, which nearly fixed early in the human lineage--a pattern unlikely to have arisen so rapidly in the absence of selection (P < 0.0097). We show that the duplication of BOLA2 led to a novel, human-specific in-frame fusion transcript and that BOLA2 copy number correlates with both RNA expression (r = 0.36) and protein level (r = 0.65), with the greatest expression difference between human and chimpanzee in experimentally derived stem cells. Analyses of 152 patients carrying a chromosome 16p11. rearrangement show that more than 96% of breakpoints occur within the H. sapiens-specific duplication. In summary, the duplicative transposition of BOLA2 at the root of the H. sapiens lineage about 282 ka simultaneously increased copy number of a gene associated with iron homeostasis and predisposed our species to recurrent rearrangements associated with disease.
[Mh] Termos MeSH primário: Cromossomos Humanos Par 16/genética
Variações do Número de Cópias de DNA/genética
Evolução Molecular
Predisposição Genética para Doença
Proteínas/genética
[Mh] Termos MeSH secundário: Animais
Transtorno Autístico/genética
Quebra Cromossômica
Duplicação Gênica
Homeostase/genética
Seres Humanos
Ferro/metabolismo
Pan troglodytes/genética
Pongo/genética
Proteínas/análise
Recombinação Genética
Especificidade da Espécie
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (BOLA2 protein, human); 0 (Proteins); E1UOL152H7 (Iron)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160804
[St] Status:MEDLINE


  9 / 197 MEDLINE  
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[PMID]:27474039
[Au] Autor:Santpere G; Lopez-Valenzuela M; Petit-Marty N; Navarro A; Espinosa-Parrilla Y
[Ad] Endereço:Department of Experimental and Health Sciences, IBE, Institute of Evolutionary Biology, (Universitat Pompeu Fabra -CSIC), Barcelona, Catalonia, Spain.
[Ti] Título:Differences in molecular evolutionary rates among microRNAs in the human and chimpanzee genomes.
[So] Source:BMC Genomics;17:528, 2016 07 29.
[Is] ISSN:1471-2164
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The rise of the primate lineage is accompanied by an outstanding emergence of microRNAs, small non-coding RNAs with a prominent role in gene regulation. In spite of their biological importance little is known about the way in which natural selection has influenced microRNAs in the human lineage. To study the recent evolutionary history of human microRNAs and to analyze the signatures of natural selection in genomic regions harbouring microRNAs we have investigated the nucleotide substitution rates of 1,872 human microRNAs in the human and chimpanzee lineages. RESULTS: We produced a depurated set of microRNA alignments of human, chimpanzee and orang-utan orthologs combining BLAT and liftOver and selected 1,214 microRNA precursors presenting optimal secondary structures. We classified microRNAs in categories depending on their genomic organization, duplication status and conservation along evolution. We compared substitution rates of the aligned microRNAs between human and chimpanzee using Tajima's Relative Rate Test taking orang-utan as out-group and found several microRNAs with particularly high substitution rates in either the human or chimpanzee branches. We fitted different models of natural selection on these orthologous microRNA alignments and compared them using a likelihood ratio test that uses ancestral repeats and microRNA flanking regions as neutral sequences. We found that although a large fraction of human microRNAs is highly conserved among the three species studied, significant differences in rates of molecular evolution exist among microRNA categories. Particularly, primate-specific microRNAs, which are enriched in isolated and single copy microRNAs, more than doubled substitution rates of those belonging to older, non primate-specific microRNA families. CONCLUSIONS: Our results corroborate the remarkable conservation of microRNAs, a proxy of their functional relevance, and indicate that a subset of human microRNAs undergo nucleotide substitutions at higher rates, which may be suggestive of the action of positive selection.
[Mh] Termos MeSH primário: MicroRNAs/genética
Pan troglodytes/genética
Pongo/genética
Análise de Sequência de RNA/métodos
[Mh] Termos MeSH secundário: Substituição de Aminoácidos
Animais
Evolução Molecular
Genoma Humano
Seres Humanos
Funções Verossimilhança
MicroRNAs/química
Modelos Genéticos
Taxa de Mutação
Seleção Genética
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (MicroRNAs)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171118
[Lr] Data última revisão:
171118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160731
[St] Status:MEDLINE
[do] DOI:10.1186/s12864-016-2863-3


  10 / 197 MEDLINE  
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[PMID]:27472575
[Au] Autor:Stock MK; Reynolds DG; Masters AJ; Bromage TG; Enlow DH
[Ti] Título:Line of Sight in Hominoids.
[So] Source:J Clin Pediatr Dent;40(3):251-8, 2016.
[Is] ISSN:1053-4628
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: It remains unclear how the realignments of the face and basicranium that characterize humans were acquired, both phylogenetically and ontogenetically. The developmentally constrained nature of the skull has been previously demonstrated in other primates using Donald H. Enlow's mammalian craniofacial architectural relationships. Here, we compare crania of our closest relatives to gain greater understanding of how and why the relationship of the face and cranial base is developmentally constrained in order to inform instances of abnormal growth and clinical intervention. STUDY DESIGN: A method for evaluating these fundamental architectural relationships using 3D landmark data was developed, thereby taking overall size and the geometric relationships among points into account. A sample of cone-beam computed tomography scans derived from humans and extant apes were analyzed (n=10 and n=6, respectively), as well as fossil hominid crania (n=7). Landmarks for 23 craniofacial architectural points were identified and recorded. RESULTS AND CONCLUSIONS: Principal components analyses reveal that despite the similarities in craniofacial architecture between humans, extant apes and fossil hominids, appreciable trends in variation between the extant species suggest that the repositioning of the foramen magnum was only one of a constellation of traits that realigned the basicranium and face during the transition to bipedalism.
[Mh] Termos MeSH primário: Face/anatomia & histologia
Ossos Faciais/anatomia & histologia
Hominidae/anatomia & histologia
Base do Crânio/anatomia & histologia
[Mh] Termos MeSH secundário: Pontos de Referência Anatômicos/anatomia & histologia
Animais
Tomografia Computadorizada de Feixe Cônico/métodos
Meato Acústico Externo/anatomia & histologia
Feminino
Forame Magno/anatomia & histologia
Fósseis
Osso Frontal/anatomia & histologia
Seres Humanos
Imagem Tridimensional/métodos
Masculino
Osso Nasal/anatomia & histologia
Órbita/anatomia & histologia
Palato Duro/anatomia & histologia
Pan troglodytes
Filogenia
Pongo
Análise de Componente Principal
Osso Temporal/anatomia & histologia
Vômer/anatomia & histologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170107
[Lr] Data última revisão:
170107
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:160730
[St] Status:MEDLINE
[do] DOI:10.17796/1053-4628-40.3.251



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